Rhein (BioDeep_00000398588)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-

化学式: C15H8O6 (284.0320868)
中文名称: 大黄酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O
InChI: InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

描述信息

D004791 - Enzyme Inhibitors
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.164
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.166

同义名列表

42 个代谢物同义名

数据库引用编号

34 个数据库交叉引用编号

分类词条

Anthracenes and phenanthrenes

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

91 个相关的物种来源信息

33090 牵牛子: -
33090 番泻叶: -
53851 决明子: -
33090 萱草根: -
33090 虎杖: -
33090 沙棘: -
33090 大黄: -
1231245 Cassia renigera: 10.1021/NP50034A033
508996 Cassia javanica:
53852 Cassia fistula:
162709 Cassia grandis: 10.1021/NP50034A033
948717 Cassia roxburghii: 10.1021/NP50034A033
72401 Senna didymobotrya:
53923 Senna alata:
137221 Rheum palmatum:
2743666 Rheum racemiferum:
137219 Rheum nanum: 10.1055/S-2008-1074562
346999 Senna siamea: 10.21608/BFSA.1985.75705
240183 Rheum kialense: 10.1016/0378-8741(84)90016-3
284362 Rheum alexandrae: 10.1016/0378-8741(84)90016-3
284363 Rheum australe:
694413 Rheum delavayi: 10.1016/0378-8741(84)90016-3
137223 Rheum pumilum: 10.1016/0378-8741(84)90016-3
205071 Rheum tataricum: 10.1016/0378-8741(84)90016-3
574896 Rheum altaicum: 10.1016/0378-8741(84)90016-3
137216 Rheum compactum: 10.1016/0378-8741(84)90016-3
694412 Rheum acuminatum: 10.1016/0378-8741(84)90016-3
137228 Rheum wittrockii: 10.1016/0378-8741(84)90016-3
137220 Rheum officinale:
3621 Rheum rhabarbarum:
240182 Rheum franzenbachii:
46087 Rheum rhaponticum: 10.1016/0378-8741(84)90016-3
137227 Rheum undulatum: 10.1016/0378-8741(84)90016-3
137697 Rheum nobile: 10.1016/0378-8741(84)90016-3
137226 Rheum tanguticum:
137217 Rheum hotaoense: 10.1016/0378-8741(84)90016-3
137218 Rheum likiangense: 10.1016/0378-8741(84)90016-3
240184 Rheum spiciforme: 10.1016/0378-8741(84)90016-3
137224 Rheum reticulatum: 10.1016/0378-8741(84)90016-3
72402 Senna alexandrina:
278676 Rumex cristatus: 10.1042/BJ0980112
362788 Senna tora: 10.1021/JF049379P
3620 Rheum:
3618 Rumex: 10.1016/J.BMCL.2013.04.059
34190 Hemerocallis fulva:
346994 Senna reticulata:
1977551 Cassia sieberiana: 10.1055/S-0028-1099898
948714 Senna sulfurea: 10.1055/S-0028-1099898
3615 Polygonaceae: 10.1016/J.FREERADBIOMED.2014.04.001
1231245 Cassia renigera: 10.1021/NP50034A033
508996 Cassia javanica:
53852 Cassia fistula:
162709 Cassia grandis: 10.1021/NP50034A033
948717 Cassia roxburghii: 10.1021/NP50034A033
72401 Senna didymobotrya:
53923 Senna alata:
137221 Rheum palmatum:
2743666 Rheum racemiferum:
137219 Rheum nanum: 10.1055/S-2008-1074562
346999 Senna siamea: 10.21608/BFSA.1985.75705
240183 Rheum kialense: 10.1016/0378-8741(84)90016-3
284362 Rheum alexandrae: 10.1016/0378-8741(84)90016-3
284363 Rheum australe:
694413 Rheum delavayi: 10.1016/0378-8741(84)90016-3
137223 Rheum pumilum: 10.1016/0378-8741(84)90016-3
205071 Rheum tataricum: 10.1016/0378-8741(84)90016-3
574896 Rheum altaicum: 10.1016/0378-8741(84)90016-3
137216 Rheum compactum: 10.1016/0378-8741(84)90016-3
694412 Rheum acuminatum: 10.1016/0378-8741(84)90016-3
137228 Rheum wittrockii: 10.1016/0378-8741(84)90016-3
137220 Rheum officinale:
3621 Rheum rhabarbarum:
240182 Rheum franzenbachii:
46087 Rheum rhaponticum: 10.1016/0378-8741(84)90016-3
137227 Rheum undulatum: 10.1016/0378-8741(84)90016-3
137697 Rheum nobile: 10.1016/0378-8741(84)90016-3
137226 Rheum tanguticum:
137217 Rheum hotaoense: 10.1016/0378-8741(84)90016-3
137218 Rheum likiangense: 10.1016/0378-8741(84)90016-3
240184 Rheum spiciforme: 10.1016/0378-8741(84)90016-3
137224 Rheum reticulatum: 10.1016/0378-8741(84)90016-3
72402 Senna alexandrina:
278676 Rumex cristatus: 10.1042/BJ0980112
362788 Senna tora: 10.1021/JF049379P
3620 Rheum:
3618 Rumex: 10.1016/J.BMCL.2013.04.059
34190 Hemerocallis fulva:
346994 Senna reticulata:
1977551 Cassia sieberiana: 10.1055/S-0028-1099898
948714 Senna sulfurea: 10.1055/S-0028-1099898
3615 Polygonaceae: 10.1016/J.FREERADBIOMED.2014.04.001

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
Shujun Xu, Shuang Zheng, Ninghui Ma, Hongyan Zhang, Jingbin Shi, Jingyi Huang, Ninghchao Luo, Menglin Wang, Yang Xiong. Rhein potentiates doxorubicin in treating triple negative breast cancer by inhibiting cancer-associated fibroblasts. Biochemical pharmacology. 2024 May; 223(?):116139. doi: 10.1016/j.bcp.2024.116139. [PMID: 38499109]
Tianyi Zhao, Shiyi Lun, Maoying Yan, JongPil Park, Shumin Wang, Changbao Chen. 6,7-Dimethoxycoumarin, Gardenoside and Rhein combination improves non-alcoholic fatty liver disease in rats. Journal of ethnopharmacology. 2024 Mar; 322(?):117646. doi: 10.1016/j.jep.2023.117646. [PMID: 38135236]
Bi Wang, Jingjing Yang, Xingzeng Zhao, Xu Feng, Shu Xu, Pirui Li, Linwei Li, Yu Chen. Antifungal activity of the botanical compound rhein against Phytophthora capsici and the underlying mechanisms. Pest management science. 2024 Mar; 80(3):1228-1239. doi: 10.1002/ps.7852. [PMID: 37897133]
Lifang Wang, Haijao Wang, Jingjing Niu, Honggang Chen, Meng Wang, Zhigang Yang, Shaohua Wang, Xiuxia Sun, Yanbin Shi. Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action. European journal of pharmacology. 2024 Jan; ?(?):176348. doi: 10.1016/j.ejphar.2024.176348. [PMID: 38286356]
Qiang Huang, Meiling Fan, Fenglan Ji, Yuqi Wang, Hongyue Ding, Jie Xu, Xin Wang, Bo Liu, Bei Wang, Xinmiao Yu, Zhidong Qiu, Fan Yao. The safety evaluation of Shenze Shugan capsule and mechanism of apoptosis induced by five potentially nephrotoxic components. Journal of ethnopharmacology. 2024 Jan; 324(?):117777. doi: 10.1016/j.jep.2024.117777. [PMID: 38219879]
Xu Zhang, Mingyang Xue, Lei Liu, Huan Wang, Tianxiu Qiu, Yan Zhou, Lipeng Shan, Zixuan Wang, Guanglu Liu, Yang Hu, Jiong Chen. Rhein: A potent immunomodulator empowering largemouth bass against MSRV infection. Fish & shellfish immunology. 2024 Jan; 144(?):109284. doi: 10.1016/j.fsi.2023.109284. [PMID: 38092092]
Jiao Wang, Jin Zhang, Zeyu Guo, Hui Hua, Hongying Zhang, Yongliang Liu, Yangfu Jiang. Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155156. doi: 10.1016/j.phymed.2023.155156. [PMID: 37897861]
Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
Yanli Wang, Siwei Zhong, Ke Yang, Ruifeng Luo, Linxin Dai, Wenzhen Zhong, Yan Ye, Chaomei Fu, Dasheng Lin, Nan Li, Jianping Chen, Chuan Zheng, Shu Fu, Fei Gao. β-1,3-d-glucan particles-based "nest" protected co-loaded Rhein and Emodin regulates microbiota and intestinal immunity for ulcerative colitis treatment. International journal of biological macromolecules. 2023 Dec; 260(Pt 2):128818. doi: 10.1016/j.ijbiomac.2023.128818. [PMID: 38103669]
Wessam M El-Refaie, Mostafa S Ghazy, Fady A Ateyya, Eman Sheta, Mohanad Y Shafek, Mahmoud S Ibrahim, Mahmoud Ma Ismail, Mennatallah A Gowayed. Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis. Inflammopharmacology. 2023 Dec; 31(6):3127-3142. doi: 10.1007/s10787-023-01295-w. [PMID: 37526838]
Huijuan Lv, Jingjing Niu, Wenhao Pan, Yudong Wang, Lifang Wang, Meng Wang, Yali Shi, Guifang Zhang, Bandar Al Hamyari, Shaohua Wang, Xuefeng Li, Yanbin Shi. Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117336. doi: 10.1016/j.jep.2023.117336. [PMID: 37907143]
Zebu Song, Yang Chen, Hao Chang, Yanchen Guo, Qi Gao, Zhi Wei, Lang Gong, Guihong Zhang, ZeZhong Zheng. Rhein suppresses African swine fever virus replication in vitro via activating the caspase-dependent mitochondrial apoptosis pathway. Virus research. 2023 Oct; ?(?):199238. doi: 10.1016/j.virusres.2023.199238. [PMID: 37827302]
Xi Mao, Ding-Qiao Xu, Shi-Jun Yue, Rui-Jia Fu, Sai Zhang, Yu-Ping Tang. Potential Medicinal Value of Rhein for Diabetic Kidney Disease. Chinese journal of integrative medicine. 2023 Oct; 29(10):951-960. doi: 10.1007/s11655-022-3591-y. [PMID: 36607584]
Hua Liu, Tian-Ai Zhang, Wen-Yue Zhang, Si-Rui Huang, Yue Hu, Jia Sun. Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway. Experimental neurology. 2023 Sep; ?(?):114541. doi: 10.1016/j.expneurol.2023.114541. [PMID: 37714424]
Pablo Zambrano, Malgorzata Jemiola-Rzeminska, Diego Muñoz-Torrero, Mario Suwalsky, Kazimierz Strzalka. A rhein-huprine hybrid protects erythrocyte membrane integrity against Alzheimer's disease related Aβ(1-42) peptide. Biophysical chemistry. 2023 09; 300(?):107061. doi: 10.1016/j.bpc.2023.107061. [PMID: 37307659]
Yahui Hu, Shasha He, Xiaolong Xu, Xuran Cui, Yiming Wei, Chunxia Zhao, Haoran Ye, Jingxia Zhao, Qingquan Liu. Shenhuangdan decoction alleviates sepsis-induced lung injury through inhibition of GSDMD-mediated pyroptosis. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117047. doi: 10.1016/j.jep.2023.117047. [PMID: 37586442]
ShengHao Chen, YanLan Liang, YuanYuan Li, Yue Sun, Yang He. Determination of rhein and physcion in rhubarb by microchip capillary electrophoresis in mixed hydro-organic solvent combined with laser-induced fluorescence detection. Journal of separation science. 2023 Jul; ?(?):e2300192. doi: 10.1002/jssc.202300192. [PMID: 37507831]
Fei Cao, Jie Xiang, Yaodong Wang, Xijie Chen, Xirong Lu, Xingmeng Xu, Lin Chen, Yinghong Fan, Chenchen Yuan, Xiaowu Dong, Qingtian Zhu, Chenxia Han, Guotao Lu, Qing Xia, Weiwei Chen. Chaiqin chengqi decoction alleviates acute pancreatitis by targeting gasdermin D-mediated pyroptosis. Journal of ethnopharmacology. 2023 Jul; 318(Pt A):116920. doi: 10.1016/j.jep.2023.116920. [PMID: 37480969]
Jianhang Bao, Wenshuo Gao, Wei Zhang, Dong Wang, Hao Pan. Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy. Journal of orthopaedic surgery and research. 2023 Jul; 18(1):485. doi: 10.1186/s13018-023-03961-9. [PMID: 37415165]
Yudan Mei, Xiaoyu Tong, Yumei Hu, Wenjun Liu, Jiajia Wang, Kaihong Lv, Xu Li, Liang Cao, Zhenzhong Wang, Wei Xiao, Xia Gao. Comparative pharmacokinetics of six bioactive components of Shen-Wu-Yi-Shen tablets in normal and chronic renal failure rats based on UPLC-TSQ-MS/MS. Journal of ethnopharmacology. 2023 Jun; 317(?):116818. doi: 10.1016/j.jep.2023.116818. [PMID: 37348793]
Xinqiu Li, Zixiang Lin, Penglong Wang, Chaoyu Zhou, Jiawei Xu, Jiahao Lin, Degui Lin, Di Zhang. Tetramethylpyrazine-Rhein Derivative inhibits the migration of canine inflammatory mammary carcinoma cells by mitochondrial damage-mediated apoptosis and cadherins downregulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114731. doi: 10.1016/j.biopha.2023.114731. [PMID: 37086510]
H Wang, M Li, S Li, J Shi, L Huang, S Cheng, C Zou, H Yan. [Spectrum-effect relationship of total anthraquinone extract of Cassia seeds against fluorouracil-induced liver injury in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 May; 43(5):825-831. doi: 10.12122/j.issn.1673-4254.2023.05.19. [PMID: 37313825]
Haibo Zhang, Lei Ma, Eungyung Kim, Junkoo Yi, Hai Huang, Hyeonjin Kim, Muhammad Atif Raza, Sijun Park, Soyoung Jang, Kirim Kim, Sung-Hyun Kim, Youngkyun Lee, Eunkyong Kim, Zae Young Ryoo, Myoung Ok Kim. Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108507. [PMID: 37239855]
Song Liu, Lei Shu, Jiayao Yang, Yi Liu, Shu Zhang, Nian Wang, Zhaohong Shi. Rhein Exhibits Anti-Inflammatory Effects in Chronic Atrophic Gastritis via Nrf2 and MAPK Signaling. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2023 05; 34(5):525-532. doi: 10.5152/tjg.2023.22251. [PMID: 36789982]
Si Li, Xi Wu, Yue Ma, Hua Zhang, Wen Chen. Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology. Journal of ethnopharmacology. 2023 Apr; ?(?):116435. doi: 10.1016/j.jep.2023.116435. [PMID: 37023836]
Fan Wu, Ting Zhao, Yu Zhang, Yan Wang, Guoxin Liao, Baojing Zhang, Chao Wang, Xiangge Tian, Lei Feng, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Beneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters. Journal of ethnopharmacology. 2023 Apr; ?(?):116449. doi: 10.1016/j.jep.2023.116449. [PMID: 37023835]
Fan Wu, Yan Wang, Quanxi Mei, Qinhua Chen, Chengpeng Sun, Xia Lv, Lei Feng, Chao Wang, Yanyan Zhang, Bangjiang Fang, Xiaokui Huo, Xiangge Tian, Xiaochi Ma. UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. Journal of ethnopharmacology. 2023 Mar; 304(?):116016. doi: 10.1016/j.jep.2022.116016. [PMID: 36535328]
Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
Wenting Su, Congyan Liu, Xi Jiang, Yanli Lv, Qin Chen, Jiachen Shi, Huangqin Zhang, Qiuling Ma, Chang Ge, Fei Kong, Xiaoqi Li, Yuping Liu, Yan Chen, Ding Qu. An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD. Journal of nanobiotechnology. 2023 Mar; 21(1):71. doi: 10.1186/s12951-023-01829-y. [PMID: 36859261]
Shunshun Chen, Meimei Wang, Linhua Yu, Jinchao Shi, Yong Zhang, Yao Tian, Li Li, Xiang Zhu, Junkai Li. Rhein-Amino Acid Ester Conjugates as Potential Antifungal Agents: Synthesis and Biological Evaluation. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052074. [PMID: 36903319]
Lingling Wang, Guoying Zhou, Shuo Zhao, Yang Yang. Soluble protein content, bioactive compounds and the antioxidant activity in seeds of ten Rheum tanguticum lines from Qinghai-Tibet Plateau. Chemistry & biodiversity. 2023 Feb; ?(?):e202200901. doi: 10.1002/cbdv.202200901. [PMID: 36788177]
Chuankui Fu, Yiheng Zhang, Wen Jie Xi, Kejia Xu, Fansheng Meng, Tianle Ma, Weidong Li, Li Wu, Zhipeng Chen. Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway. Journal of ethnopharmacology. 2023 Jan; 308(?):116191. doi: 10.1016/j.jep.2023.116191. [PMID: 36731809]
Qili Wang, Shunping Han, Yongqin Zhu, Guowei Wang, Danfei Chen. Poly-γ-glutamic acid coating polymeric nanoparticles enhance renal drug distribution and cellular uptake for diabetic nephropathy therapy. Journal of drug targeting. 2023 01; 31(1):89-99. doi: 10.1080/1061186x.2022.2106488. [PMID: 35880399]
Jijia Sun, Qinghua Ni, Fengyan Jiang, Baocheng Liu, Jianying Wang, Lei Zhang, Jihan Huang. Discovery and Validation of Traditional Chinese and Western Medicine Combination Antirheumatoid Arthritis Drugs Based on Machine Learning (Random Forest Model). BioMed research international. 2023; 2023(?):6086388. doi: 10.1155/2023/6086388. [PMID: 36845640]
Heba M K Ebada, Maha M A Nasra, Rasha A Nassra, Ossama Y Abdallah. Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment. Drug delivery. 2022 Dec; 29(1):652-663. doi: 10.1080/10717544.2022.2041130. [PMID: 35188017]
Shanshan Qi, Ruifeng Luo, Xiaoqin Han, Wenbiao Nie, Naijing Ye, Chaomei Fu, Fei Gao. pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance "One Stone Four Birds" Effect of Rhein on Ulcerative Colitis. ACS applied materials & interfaces. 2022 Nov; 14(45):50692-50709. doi: 10.1021/acsami.2c17827. [PMID: 36326017]
Ya Zhao, Jinqiu Wang, Lijuan Liu, Yayun Wu, Qiaohong Hu, Ruizhi Zhao. Vinegar-baked Radix Bupleuri enhances the liver-targeting effect of rhein on liver injury rats by regulating transporters. The Journal of pharmacy and pharmacology. 2022 Nov; 74(11):1588-1597. doi: 10.1093/jpp/rgac062. [PMID: 36181768]
Yanna Zhu, Shilei Yang, Linlin Lv, Xiaohan Zhai, Guoyu Wu, Xiaolin Qi, Deshi Dong, Xufeng Tao. Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets. Molecules (Basel, Switzerland). 2022 Oct; 27(19):. doi: 10.3390/molecules27196572. [PMID: 36235108]
Ning Xu, Yuanran Chen, Dongjie Guo, Yu Deng, Wanjun Guo, Xin Liu, Yi Wang, Hanzhi Lu, Aijun Liu, Jianyong Zhu, Fulun Li. Rhein promotes the proliferation of keratinocytes by targeting oestrogen receptors for skin ulcer treatment. BMC complementary medicine and therapies. 2022 Aug; 22(1):209. doi: 10.1186/s12906-022-03691-1. [PMID: 35932049]
Veronica Folliero, Federica Dell'Annunziata, Emanuela Roscetto, Alessandra Amato, Roberta Gasparro, Carla Zannella, Vincenzo Casolaro, Anna De Filippis, Maria Rosaria Catania, Gianluigi Franci, Massimiliano Galdiero. Rhein: A novel antibacterial compound against Streptococcus mutans infection. Microbiological research. 2022 Aug; 261(?):127062. doi: 10.1016/j.micres.2022.127062. [PMID: 35597077]
Fan Wu, Baojing Zhang, Yu Zhang, Ting Zhao, Yan Wang, Xiangge Tian, Chengpeng Sun, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Simultaneous Determination of Ten Active Components From Jinhongtang Granule in Rat Plasma by LC-MS/MS and its Application to a Comparative Pharmacokinetic Study in Normal and Sepsis Rats In Vivo and In Vitro. Journal of chromatographic science. 2022 Aug; ?(?):. doi: 10.1093/chromsci/bmac043. [PMID: 35913259]
Fei Gao, Hui-Yun Zhong, Ke-Xi Chen, Ling-Ling Dong, Mei-Si Lin, Hong-Ling DU. [Mechanism of combined treatment of rhein and emodin in Rhubarb for ulcerative colitis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Aug; 47(15):4148-4155. doi: 10.19540/j.cnki.cjcmm.20220509.702. [PMID: 36046905]
Qiming Xiao, Xixi Yu, Xinwei Yu, Shundi Liu, Jianping Jiang, Yu Cheng, Hao Lin, Yuzhen Wang, Xiaoshan Zhang, Xiaoxia Ye, Zheng Xiang. An integrated network pharmacology and cell metabolomics approach to reveal the role of rhein, a novel PPARα agonist, against renal fibrosis by activating the PPARα-CPT1A axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154147. doi: 10.1016/j.phymed.2022.154147. [PMID: 35567992]
Gang Min Li, Jun Ren Chen, Hui Qiong Zhang, Chen Sun, Guan Ru Chen, Qiu Yun Xiong, Xiao Yu Cao, Lei Yu, Zi Wei Lin, Jun Yuan Qin, Liu Jun Wu, Jing Li, Lin Pu, Fu Peng, Xiao Fang Xie, Cheng Peng. Rhein activated Fas-induced apoptosis pathway causing cardiotoxicity in vitro and in vivo. Toxicology letters. 2022 Jun; 363(?):67-76. doi: 10.1016/j.toxlet.2022.04.006. [PMID: 35589017]
Dong Yang, Wan-Yi Huang, Yan-Qiao Li, Shi-Yu Chen, Si-Yu Su, Yue Gao, Xian-Li Meng, Ping Wang. Acute and subchronic toxicity studies of rhein in immature and d-galactose-induced aged mice and its potential hepatotoxicity mechanisms. Drug and chemical toxicology. 2022 May; 45(3):1119-1130. doi: 10.1080/01480545.2020.1809670. [PMID: 32842782]
Lingling Dong, Hongling Du, Minyue Zhang, Haiting Xu, Xiulan Pu, Qiyan Chen, Ruifeng Luo, Yichen Hu, Yitao Wang, He Tu, Jinming Zhang, Fei Gao. Anti-inflammatory effect of Rhein on ulcerative colitis via inhibiting PI3K/Akt/mTOR signaling pathway and regulating gut microbiota. Phytotherapy research : PTR. 2022 May; 36(5):2081-2094. doi: 10.1002/ptr.7429. [PMID: 35229916]
Xianrui Song, Zesen Du, Zhenqi Yao, Xiaoyan Tang, Mian Zhang. Rhein Improves Renal Fibrosis by Restoring Cpt1a-Mediated Fatty Acid Oxidation through SirT1/STAT3/twist1 Pathway. Molecules (Basel, Switzerland). 2022 Apr; 27(7):. doi: 10.3390/molecules27072344. [PMID: 35408745]
Feng Junfang, Chen Ou, Wang Yibiao. Anti-inflammatory mechanism of rhein in treating asthma based on network pharmacology. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 04; 42(2):296-303. doi: 10.19852/j.cnki.jtcm.20220225.003. [PMID: 35473352]
Yue Li, Dongming Yan, Jingyi Jin, Bo Tan, Xi Chen, Bin Zou, Guochao Song, Fengyi Weng, Chenghai Liu, Furong Qiu. Clarify the potential cholestatic hepatotoxicity components from Chinese Herb Medicine and metabolism's role via hBSEP vesicles and S9/hBSEP vesicles. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Apr; 80(?):105324. doi: 10.1016/j.tiv.2022.105324. [PMID: 35101544]
Feng Gao, Rui Li, Pei-Feng Wei, Li Ou, Min Li, Yang Bai, Wen-Jia Luo, Zheng Fan. Synergistic anticancer effects of everolimus (RAD001) and Rhein on gastric cancer cells via phosphoinositide-3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway. Bioengineered. 2022 03; 13(3):6332-6342. doi: 10.1080/21655979.2021.2005988. [PMID: 35209807]
Heba Mk Ebada, Maha Ma Nasra, Rasha A Nassra, Amany A Solaiman, Ossama Y Abdallah. Cationic nanocarrier of rhein based on hydrophobic ion pairing approach as intra-articular targeted regenerative therapy for osteoarthritis. Colloids and surfaces. B, Biointerfaces. 2022 Mar; 211(?):112285. doi: 10.1016/j.colsurfb.2021.112285. [PMID: 34942464]
Yanchun Hu, Samuel Kumi Okyere, Ruiguang Xu, Guangneng Peng, Zhihua Ren, Junliang Deng, Yan Jia. Assessment of antiviral activity and mechanism of rhein on newcastle disease virus (La Sota strain IV) in vitro. Natural product research. 2022 Mar; 36(5):1400-1404. doi: 10.1080/14786419.2021.1878515. [PMID: 33527842]
Jia-You Fang, Tse-Hung Huang, Wei-Jhang Chen, Ibrahim A Aljuffali, Ching-Yun Hsu. Rhubarb hydroxyanthraquinones act as antiobesity agents to inhibit adipogenesis and enhance lipolysis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112497. doi: 10.1016/j.biopha.2021.112497. [PMID: 34891117]
Hui Yang, Bingtao Zhai, Mei Wang, Yu Fan, Jing Wang, Jiangxue Cheng, Junbo Zou, Xiaofei Zhang, Yajun Shi, Dongyan Guo, Zhishu Tang. The influence of rhein on the absorption of rehmaionoside D: In vivo, in situ, in vitro, and in silico studies. Journal of ethnopharmacology. 2022 Jan; 282(?):114650. doi: 10.1016/j.jep.2021.114650. [PMID: 34536515]
Shuhui Liu, Ruiying Yin, Ziwei Yang, Feili Wei, Jianhua Hu. The effects of rhein on D-GalN/LPS-induced acute liver injury in mice: Results from gut microbiome-metabolomics and host transcriptome analysis. Frontiers in immunology. 2022; 13(?):971409. doi: 10.3389/fimmu.2022.971409. [PMID: 36389730]
Jinxin Liu, Dapeng Ding, Feiye Liu, Yizhi Chen. Rhein Inhibits the Progression of Chemoresistant Lung Cancer Cell Lines via the Stat3/Snail/MMP2/MMP9 Pathway. BioMed research international. 2022; 2022(?):7184871. doi: 10.1155/2022/7184871. [PMID: 35178453]
Chwan-Fwu Lin, Shih-Yi Chuang, Tse-Hung Huang, Thi My Huyen Nguyen, Pei-Wen Wang, Ahmed Alalaiwe, Jia-You Fang. A systematic comparison of the effect of topically applied anthraquinone aglycones to relieve psoriasiform lesion: The evaluation of percutaneous absorption and anti-inflammatory potency. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112482. doi: 10.1016/j.biopha.2021.112482. [PMID: 34915669]
Li Ji, Huan Gu. The anti-obesity effects of rhein on improving insulin resistance (IR) and blood lipid levels are involved in endoplasmic reticulum stress (ERs), inflammation, and oxidative stress in vivo and vitro. Bioengineered. 2021 12; 12(1):5797-5813. doi: 10.1080/21655979.2021.1969196. [PMID: 34516329]
Hui Dai, Yulin Wang, Chenchen Ren, Xiaojun Ji, Yueke Zhou, Xinyue Zhang, Fangzhou Yin, Wu Yin, Zhonghua Tao. A new method for detecting Na+ , K+ -ATPase activity by ICP-MS: Quantitative analysis on the inhibitory effect of rhein on Na+ , K+ -ATPase activity by ICP-MS in HCT116 cells. Biomedical chromatography : BMC. 2021 Dec; 35(12):e5199. doi: 10.1002/bmc.5199. [PMID: 34144633]
Nicholas C Harvey, Cyrus Cooper, Zahra Raisi-Estabragh. Vitamin D supplementation and COVID-19 disease: safety but unproven efficacy-reply to Dr Helga Rhein. Aging clinical and experimental research. 2021 09; 33(9):2635-2636. doi: 10.1007/s40520-021-01947-3. [PMID: 34406642]
Yitong Liu, Mapa S T Mapa, Robert L Sprando. Anthraquinones inhibit cytochromes P450 enzyme activity in silico and in vitro. Journal of applied toxicology : JAT. 2021 09; 41(9):1438-1445. doi: 10.1002/jat.4134. [PMID: 33438235]
Meiyou Liu, Lei Wang, Xiaoxiao Wu, Kai Gao, Fan Wang, Jia Cui, Jinyi Zhao, Li Peng, Jingwen Wang, Yanyan Jia, Aidong Wen. Rhein protects 5/6 nephrectomized rat against renal injury by reducing inflammation via NF-κB signaling. International urology and nephrology. 2021 Jul; 53(7):1473-1482. doi: 10.1007/s11255-020-02739-w. [PMID: 33763781]
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Qiyan Chen, Ruifeng Luo, Xiaoqin Han, Jinming Zhang, Yao He, Shanshan Qi, Xiulan Pu, Wenbiao Nie, Lingling Dong, Haiting Xu, Fang Liu, Meisi Lin, Huiyun Zhong, Chaomei Fu, Fei Gao. Entrapment of Macrophage-Target Nanoparticles by Yeast Microparticles for Rhein Delivery in Ulcerative Colitis Treatment. Biomacromolecules. 2021 06; 22(6):2754-2767. doi: 10.1021/acs.biomac.1c00425. [PMID: 34019390]
Yingfan Hu, Wen'ge Huang, Yu Luo, Li Xiang, Jiasi Wu, Yan Zhang, Yong Zeng, Chensi Xu, Xianli Meng, Ping Wang. Assessment of the anti-inflammatory effects of three rhubarb anthraquinones in LPS-Stimulated RAW264.7 macrophages using a pharmacodynamic model and evaluation of the structure-activity relationships. Journal of ethnopharmacology. 2021 Jun; 273(?):114027. doi: 10.1016/j.jep.2021.114027. [PMID: 33741438]
Heba M K Ebada, Maha M A Nasra, Yosra S R Elnaggar, Rasha A Nassra, Amany A Solaiman, Ossama Y Abdallah. Novel rhein integrate transphytosomes as non-invasive local therapy for osteoarthritis to ameliorate cartilage deterioration in MIA-arthritic rats. Colloids and surfaces. B, Biointerfaces. 2021 Jun; 202(?):111713. doi: 10.1016/j.colsurfb.2021.111713. [PMID: 33780905]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Libang Zhang, Dongjian Zhang, Meng Gao, Qiaomei Jin, Cuihua Jiang, Tianze Wu, Yuanbo Feng, Yicheng Ni, Zhiqi Yin, Jian Zhang. Design and Evaluation of Rhein-Based MRI Contrast Agents for Visualization of Tumor Necrosis Induced by Combretastatin A-4 Disodium Phosphate. Molecular imaging and biology. 2021 04; 23(2):220-229. doi: 10.1007/s11307-020-01551-3. [PMID: 33048270]
Wenjie Yao, Zhishi Xu, Jiang Sun, Jingwen Luo, Yinghui Wei, Jiafeng Zou. Deoxycholic acid-functionalised nanoparticles for oral delivery of rhein. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Apr; 159(?):105713. doi: 10.1016/j.ejps.2021.105713. [PMID: 33453389]
Liping Ma, Zhuowei Shen, Haihong Hu, Hui Zhou, Lushan Yu, Huidi Jiang, Su Zeng. Effects of rhein and Rheum palmatum L. extract on the pharmacokinetics and tissue distribution of aristolochic acid I and its demethylated metabolite in rats. Journal of ethnopharmacology. 2021 Mar; 267(?):113537. doi: 10.1016/j.jep.2020.113537. [PMID: 33137430]
Ying Cheng, Huiqin Zhang, Lejing Qu, Ying He, Michael N Routledge, Yun Yun Gong, Boling Qiao. Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones. Food chemistry. 2020 Nov; 331(?):127363. doi: 10.1016/j.foodchem.2020.127363. [PMID: 32590269]
Dongjian Zhang, Qiaomei Jin, Yicheng Ni, Jian Zhang. Discovery of necrosis avidity of rhein and its applications in necrosis imaging. Journal of drug targeting. 2020 11; 28(9):904-912. doi: 10.1080/1061186x.2020.1759079. [PMID: 32314601]
Yiting Shen, Feng Feng, Hao Sun, Guowei Li, Zheng Xiang. Quantitative and network pharmacology: A case study of rhein alleviating pathological progress of renal interstitial fibrosis. Journal of ethnopharmacology. 2020 Oct; 261(?):113106. doi: 10.1016/j.jep.2020.113106. [PMID: 32553981]
Wei Huang, Hang Liu, Yu Li, Gang Mai. The Effects of Rhein and Honokiol on Metabolic Profiles in a Mouse Model of Acute Pancreatitis. Medical science monitor : international medical journal of experimental and clinical research. 2020 Oct; 26(?):e925727. doi: 10.12659/msm.925727. [PMID: 33095758]
Jiacai Hu, Zhijie Yang, Hao Wu, Daochun Wang. Rhein attenuates renal inflammatory injury of uric acid nephropathy via lincRNA-Cox2/miR-150-5p/STAT1 axis. International immunopharmacology. 2020 Aug; 85(?):106620. doi: 10.1016/j.intimp.2020.106620. [PMID: 32504995]
Danting Li, Bo Lv, Di Wang, Doudou Xu, Siyuan Qin, Ying Zhang, Jie Chen, Wei Zhang, Zunjian Zhang, Fengguo Xu. Network Pharmacology and Bioactive Equivalence Assessment Integrated Strategy Driven Q-markers Discovery for Da-Cheng-Qi Decoction to Attenuate Intestinal Obstruction. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Jul; 72(?):153236. doi: 10.1016/j.phymed.2020.153236. [PMID: 32464544]
Aimi Zhang, Tianze Wu, Li Bian, Panli Li, Qiufang Liu, Dongjian Zhang, Qiaomei Jin, Jian Zhang, Gang Huang, Shaoli Song. Synthesis and Evaluation of Ga-68-Labeled Rhein for Early Assessment of Treatment-Induced Tumor Necrosis. Molecular imaging and biology. 2020 06; 22(3):515-525. doi: 10.1007/s11307-019-01365-y. [PMID: 31250330]
Sahu Henamayee, Kishore Banik, Bethsebie Lalduhsaki Sailo, Bano Shabnam, Choudhary Harsha, Satti Srilakshmi, Naidu Vgm, Seung Ho Baek, Kwang Seok Ahn, Ajaikumar B Kunnumakkara. Therapeutic Emergence of Rhein as a Potential Anticancer Drug: A Review of Its Molecular Targets and Anticancer Properties. Molecules (Basel, Switzerland). 2020 May; 25(10):. doi: 10.3390/molecules25102278. [PMID: 32408623]
Xiaoxiao Wu, Meiyou Liu, Guo Wei, Yue Guan, Jialin Duan, Miaomiao Xi, Jingwen Wang. Renal protection of rhein against 5/6 nephrectomied-induced chronic kidney disease: role of SIRT3-FOXO3α signalling pathway. The Journal of pharmacy and pharmacology. 2020 May; 72(5):699-708. doi: 10.1111/jphp.13234. [PMID: 32196681]
Yaqing Zhang, Mei Zhang, Guangnan Hu, Zunjian Zhang, Rui Song. Elevated system exposures of baicalin after combinatory oral administration of rhein and baicalin: Mainly related to breast cancer resistance protein (ABCG2), not UDP-glucuronosyltransferases. Journal of ethnopharmacology. 2020 Mar; 250(?):112528. doi: 10.1016/j.jep.2019.112528. [PMID: 31884038]
Ya Zhao, Peng Wan, Jinqiu Wang, Ping Li, Qiaohong Hu, Ruizhi Zhao. Polysaccharide from vinegar baked radix bupleuri as efficient solubilizer for water-insoluble drugs of Chinese medicine. Carbohydrate polymers. 2020 Feb; 229(?):115473. doi: 10.1016/j.carbpol.2019.115473. [PMID: 31826443]
Xiaoying Wang, Liangzhen Qiu, Xiaying Wang, Huizhi Ouyang, Tonglei Li, Lifeng Han, Xue Zhang, Wei Xu, Kedan Chu. Evaluation of intestinal permeation enhancement with carboxymethyl chitosan-rhein polymeric micelles for oral delivery of paclitaxel. International journal of pharmaceutics. 2020 Jan; 573(?):118840. doi: 10.1016/j.ijpharm.2019.118840. [PMID: 31715358]
Jiawei Wu, Zhonghong Wei, Peng Cheng, Cheng Qian, Fangming Xu, Yu Yang, Aiyun Wang, Wenxing Chen, Zhiguang Sun, Yin Lu. Rhein modulates host purine metabolism in intestine through gut microbiota and ameliorates experimental colitis. Theranostics. 2020; 10(23):10665-10679. doi: 10.7150/thno.43528. [PMID: 32929373]
Zhong Xian, Jingzhuo Tian, Lianmei Wang, Yushi Zhang, Jiayin Han, Nuo Deng, Suyan Liu, Yong Zhao, Chunyin Li, Yan Yi, Dunfang Wang, Jing Meng, Chen Pan, Aihua Liang. Effects of Rhein on Bile Acid Homeostasis in Rats. BioMed research international. 2020; 2020(?):8827955. doi: 10.1155/2020/8827955. [PMID: 33274227]
Shun-Li Xiao, Liang-Jun Guan, Ren-Feng Jiang, Xiang-Gen Wang, Xing Li, Wei Cai. The Metabolism and Pharmacokinetics of Rhein and Aurantio-Obtusin. Current drug metabolism. 2020; 21(12):960-968. doi: 10.2174/1389200221666200719002128. [PMID: 32682364]
Mingyan Wei, Tao Yang, Qian Li, Dongdong Zhou, Zongpan Du, Yongping Fan. Protective effects of catalpol and rhein in murine experimental autoimmune encephalomyelitis via regulation of T helper (Th) 1, Th2, Th17, and regulatory T cell responses. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2019 12; 39(6):809-817. doi: . [PMID: 32186151]
Yanglei Li, Fang Shen, Yiqi Bao, Dongming Chen, Hong Lu. Apoptotic effects of rhein through the mitochondrial pathways, two death receptor pathways, and reducing autophagy in human liver L02 cells. Environmental toxicology. 2019 Dec; 34(12):1292-1302. doi: 10.1002/tox.22830. [PMID: 31436023]
Tianze Wu, Jian Zhang, Qiaomei Jin, Meng Gao, Dongjian Zhang, Libang Zhang, Yuanbo Feng, Yicheng Ni, Zhiqi Yin. Rhein-based necrosis-avid MRI contrast agents for early evaluation of tumor response to microwave ablation therapy. Magnetic resonance in medicine. 2019 12; 82(6):2212-2224. doi: 10.1002/mrm.27887. [PMID: 31418484]
Jinlan Yang, An Zhu, Shuo Xiao, Tao Zhang, Liming Wang, Qi Wang, Lifeng Han. Anthraquinones in the aqueous extract of Cassiae semen cause liver injury in rats through lipid metabolism disorder. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Nov; 64(?):153059. doi: 10.1016/j.phymed.2019.153059. [PMID: 31401496]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Zhanyun Shen, Bo Zhu, Jiao Li, Luping Qin. Rhein Augments Antiproliferative Effects of Atezolizumab Based on Breast Cancer (4T1) Regression. Planta medica. 2019 Oct; 85(14-15):1143-1149. doi: 10.1055/a-1012-7034. [PMID: 31559608]
Yakun Chen, Lin Mu, Lingling Xing, Shaomei Li, Shuxia Fu. Rhein alleviates renal interstitial fibrosis by inhibiting tubular cell apoptosis in rats. Biological research. 2019 Sep; 52(1):50. doi: 10.1186/s40659-019-0257-0. [PMID: 31492196]
Jiajia Liang, Qi Luo, Dongjian Zhang, Qiaomei Jin, Lichao Liu, Wei Liu, Meng Gao, Jian Zhang, Zhiqi Yin. SPECT Imaging of Treatment-Related Tumor Necrosis Using Technetium-99m-Labeled Rhein. Molecular imaging and biology. 2019 08; 21(4):660-668. doi: 10.1007/s11307-018-1285-9. [PMID: 30338432]
Yunchang Fan, Zeyu Niu, Chen Xu, Lei Yang, Tuojie Yang. Protic Ionic Liquids as Efficient Solvents in Microwave-Assisted Extraction of Rhein and Emodin from Rheum palmatum L. Molecules (Basel, Switzerland). 2019 Jul; 24(15):. doi: 10.3390/molecules24152770. [PMID: 31366111]
Shen Zhuang, Jia Zhong, Qilv Zhou, Yuan Zhong, Ping Liu, Zhongjie Liu. Rhein protects against barrier disruption and inhibits inflammation in intestinal epithelial cells. International immunopharmacology. 2019 Jun; 71(?):321-327. doi: 10.1016/j.intimp.2019.03.030. [PMID: 30952096]
Bancha Yingngam, Haiyu Zhao, Bian Baolin, Nipawan Pongprom, Adelheid Brantner. Optimization of Ultrasonic-Assisted Extraction and Purification of Rhein from Cassia fistula Pod Pulp. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24102013. [PMID: 31130673]
Rong-Rong Li, Xue-Fang Liu, Su-Xiang Feng, Sheng-Nan Shu, Pei-Yang Wang, Na Zhang, Jian-Sheng Li, Ling-Bo Qu. Pharmacodynamics of Five Anthraquinones (Aloe-emodin, Emodin, Rhein, Chysophanol, and Physcion) and Reciprocal Pharmacokinetic Interaction in Rats with Cerebral Ischemia. Molecules (Basel, Switzerland). 2019 May; 24(10):. doi: 10.3390/molecules24101898. [PMID: 31108858]
Liying Zhang, Chunshan Quan, Xuning Zhang, Wen Xiong, Shengdi Fan. Proteoliposome-based model for screening inhibitors targeting histidine kinase AgrC. Chemical biology & drug design. 2019 05; 93(5):712-723. doi: 10.1111/cbdd.13497. [PMID: 30737896]