Rhein (BioDeep_00000398588)

Main id: BioDeep_00000002810

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-

化学式: C15H8O6 (284.0321)
中文名称: 大黄酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O
InChI: InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)

描述信息

D004791 - Enzyme Inhibitors
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.164
relative retention time with respect to 9-anthracene Carboxylic Acid is 1.166

同义名列表

44 个代谢物同义名

2-Anthracenecarboxylic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracene carboxylic acid; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; 4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid; 9,10-Dihydro-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid; 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo- (8CI); 2-Anthroic acid, 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-; 4,5-dihydroxy-9,10-diketo-anthracene-2-carboxylic acid; 4,5-dihydroxy-9,10-dioxo-anthracene-2-carboxylic acid; 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid; 4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid; Rhein (1,8-dihydroxy-3-carboxyl anthraquinone); 4-10-00-04088 (Beilstein Handbook Reference); 4,5-Dihydroxy-2-anthraquinonecarboxylic acid; 4,5-dihydroxyanthraquinone-2-carboxylic acid; 1,8-Dihydroxyanthraquinone-3-carboxylic acid; 1,8-DIHYDROXY-3-CARBOXYL ANTHRAQUINONE; 4,5-DiOH-anthraquinone-2-COOH; Chrysazin-3-carboxylic acid; EINECS 207-521-4; NCGC00023342-03; Rhubarb Yellow; 275611_ALDRICH; MEGxp0_001866; LMPK02000044; MLS000069639; ACon1_000217; SMR000058210; AIDS-001379; R7269_SIGMA; Cassic acid; BRN 2222155; AIDS001379; CCRIS 5129; Rheic acid; Monorhein; NSC 38629; SBB001152; 478-43-3; NSC38629; C10401; Rhein; Rhein; Rhein



数据库引用编号

39 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

49 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, ALB, ANG, CASP3, ESR1, MAPK14, MAPK8, MTOR, NFATC1, PIK3CA, PIK3R6, PTEN, PTGS2
Peripheral membrane protein 4 ESR1, MTOR, PIK3R6, PTGS2
Endoplasmic reticulum membrane 2 MTOR, PTGS2
Nucleus 12 AKT1, ALB, ANG, CASP3, ESR1, JUN, JUND, MAPK14, MAPK8, MTOR, NFATC1, PTEN
cytosol 12 AKT1, ALB, ANG, CASP3, ESR1, MAPK14, MAPK8, MTOR, NFATC1, PIK3CA, PIK3R6, PTEN
dendrite 1 MTOR
nuclear body 1 NFATC1
phagocytic vesicle 1 MTOR
centrosome 1 ALB
nucleoplasm 10 AKT1, CASP3, ESR1, JUN, JUND, MAPK14, MAPK8, MTOR, NFATC1, PTEN
RNA polymerase II transcription regulator complex 2 JUN, JUND
Cell membrane 4 AKT1, ESR1, PIK3R6, TNF
Cytoplasmic side 2 ESR1, MTOR
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 PLG, TNF
glutamatergic synapse 4 AKT1, CASP3, MAPK14, PLG
Golgi apparatus 2 ALB, ESR1
Golgi membrane 2 INS, MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 3 ANG, CASP3, TNF
postsynapse 1 AKT1
Lysosome 1 MTOR
plasma membrane 8 AKT1, ESR1, PIK3CA, PIK3R6, PLG, PTEN, TNF, TREM2
Membrane 5 AKT1, ESR1, MTOR, PIK3R6, TREM2
apical plasma membrane 1 PTEN
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 2 ALB, PLG
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALB, PTGS2
extracellular space 6 ALB, ANG, IL6, INS, PLG, TNF
perinuclear region of cytoplasm 2 NFATC1, PIK3CA
Schaffer collateral - CA1 synapse 1 PLG
intercalated disc 1 PIK3CA
mitochondrion 1 MAPK14
protein-containing complex 4 AKT1, ALB, ESR1, PTGS2
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 2 CASP3, PTEN
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TREM2
Secreted 5 ALB, ANG, IL6, INS, PLG
extracellular region 9 ALB, ANG, IL6, INS, MAPK14, PLG, PTEN, TNF, TREM2
cytoplasmic side of plasma membrane 1 PTEN
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
[Isoform 2]: Secreted 1 TREM2
anchoring junction 1 ALB
transcription regulator complex 4 ESR1, JUN, JUND, NFATC1
external side of plasma membrane 2 PLG, TNF
actin cytoskeleton 1 ANG
dendritic spine 1 PTEN
microtubule cytoskeleton 1 AKT1
nucleolus 1 ANG
sarcoplasm 1 NFATC1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
spindle 1 AKT1
basement membrane 1 ANG
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 2 MTOR, PTEN
PML body 2 MTOR, PTEN
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 PLG
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, neuron projection 1 PTEN
neuron projection 2 PTEN, PTGS2
ciliary basal body 2 AKT1, ALB
chromatin 4 ESR1, JUN, JUND, NFATC1
cell projection 1 PTEN
phagocytic cup 1 TNF
Chromosome 1 ANG
centriole 1 ALB
Nucleus, nucleolus 1 ANG
spindle pole 2 ALB, MAPK14
nuclear chromosome 1 JUN
blood microparticle 2 ALB, PLG
[Isoform 3]: Secreted 1 TREM2
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 2 ESR1, JUN
plasma membrane raft 1 TREM2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, IL6, INS, PTGS2
transcription repressor complex 1 JUND
platelet alpha granule lumen 2 ALB, PLG
phosphatidylinositol 3-kinase complex 2 PIK3CA, PIK3R6
phosphatidylinositol 3-kinase complex, class IA 2 PIK3CA, PIK3R6
endocytic vesicle 1 ANG
transport vesicle 1 INS
Schmidt-Lanterman incisure 1 PTEN
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
semaphorin receptor complex 1 TREM2
[Isoform 1]: Nucleus 1 ESR1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 TREM2
Cytoplasmic vesicle, phagosome 1 MTOR
transcription factor AP-1 complex 2 JUN, JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
interleukin-6 receptor complex 1 IL6
myelin sheath adaxonal region 1 PTEN
[Isoform alpha]: Secreted 1 PTEN
phosphatidylinositol 3-kinase complex, class IB 2 PIK3CA, PIK3R6
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Huang-Fei Jin, Qian-Xue Shen, Ying Shi, Fang-Ming Liu, Bin Wang, Jun Cao, Li-Hong Ye. Magnetic-stirring-enhanced mechanical amorphous dispersion extraction for the hydrophobic phytochemical constituents using an aqueous solution from a medicinal plant. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116191. doi: 10.1016/j.jpba.2024.116191. [PMID: 38728950]
  • Shujun Xu, Shuang Zheng, Ninghui Ma, Hongyan Zhang, Jingbin Shi, Jingyi Huang, Ninghchao Luo, Menglin Wang, Yang Xiong. Rhein potentiates doxorubicin in treating triple negative breast cancer by inhibiting cancer-associated fibroblasts. Biochemical pharmacology. 2024 May; 223(?):116139. doi: 10.1016/j.bcp.2024.116139. [PMID: 38499109]
  • Tianyi Zhao, Shiyi Lun, Maoying Yan, JongPil Park, Shumin Wang, Changbao Chen. 6,7-Dimethoxycoumarin, Gardenoside and Rhein combination improves non-alcoholic fatty liver disease in rats. Journal of ethnopharmacology. 2024 Mar; 322(?):117646. doi: 10.1016/j.jep.2023.117646. [PMID: 38135236]
  • Bi Wang, Jingjing Yang, Xingzeng Zhao, Xu Feng, Shu Xu, Pirui Li, Linwei Li, Yu Chen. Antifungal activity of the botanical compound rhein against Phytophthora capsici and the underlying mechanisms. Pest management science. 2024 Mar; 80(3):1228-1239. doi: 10.1002/ps.7852. [PMID: 37897133]
  • Lifang Wang, Haijao Wang, Jingjing Niu, Honggang Chen, Meng Wang, Zhigang Yang, Shaohua Wang, Xiuxia Sun, Yanbin Shi. Cholesterol-lowering effects of rhubarb free anthraquinones and their mechanism of action. European journal of pharmacology. 2024 Jan; ?(?):176348. doi: 10.1016/j.ejphar.2024.176348. [PMID: 38286356]
  • Qiang Huang, Meiling Fan, Fenglan Ji, Yuqi Wang, Hongyue Ding, Jie Xu, Xin Wang, Bo Liu, Bei Wang, Xinmiao Yu, Zhidong Qiu, Fan Yao. The safety evaluation of Shenze Shugan capsule and mechanism of apoptosis induced by five potentially nephrotoxic components. Journal of ethnopharmacology. 2024 Jan; 324(?):117777. doi: 10.1016/j.jep.2024.117777. [PMID: 38219879]
  • Xu Zhang, Mingyang Xue, Lei Liu, Huan Wang, Tianxiu Qiu, Yan Zhou, Lipeng Shan, Zixuan Wang, Guanglu Liu, Yang Hu, Jiong Chen. Rhein: A potent immunomodulator empowering largemouth bass against MSRV infection. Fish & shellfish immunology. 2024 Jan; 144(?):109284. doi: 10.1016/j.fsi.2023.109284. [PMID: 38092092]
  • Jiao Wang, Jin Zhang, Zeyu Guo, Hui Hua, Hongying Zhang, Yongliang Liu, Yangfu Jiang. Targeting HSP70 chaperones by rhein sensitizes liver cancer to artemisinin derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155156. doi: 10.1016/j.phymed.2023.155156. [PMID: 37897861]
  • Fang Zhang, Rui Wu, Yanfang Liu, Shu Dai, Xinyan Xue, Xiaohong Gong, Yunxia Li. Comparative Pharmacokinetic Study of Rhubarb Anthraquinones in Normal and Nonalcoholic Fatty Liver Disease Rats. European journal of drug metabolism and pharmacokinetics. 2024 Jan; 49(1):111-121. doi: 10.1007/s13318-023-00875-z. [PMID: 38112917]
  • Yanli Wang, Siwei Zhong, Ke Yang, Ruifeng Luo, Linxin Dai, Wenzhen Zhong, Yan Ye, Chaomei Fu, Dasheng Lin, Nan Li, Jianping Chen, Chuan Zheng, Shu Fu, Fei Gao. β-1,3-d-glucan particles-based "nest" protected co-loaded Rhein and Emodin regulates microbiota and intestinal immunity for ulcerative colitis treatment. International journal of biological macromolecules. 2023 Dec; 260(Pt 2):128818. doi: 10.1016/j.ijbiomac.2023.128818. [PMID: 38103669]
  • Wessam M El-Refaie, Mostafa S Ghazy, Fady A Ateyya, Eman Sheta, Mohanad Y Shafek, Mahmoud S Ibrahim, Mahmoud Ma Ismail, Mennatallah A Gowayed. Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis. Inflammopharmacology. 2023 Dec; 31(6):3127-3142. doi: 10.1007/s10787-023-01295-w. [PMID: 37526838]
  • Huijuan Lv, Jingjing Niu, Wenhao Pan, Yudong Wang, Lifang Wang, Meng Wang, Yali Shi, Guifang Zhang, Bandar Al Hamyari, Shaohua Wang, Xuefeng Li, Yanbin Shi. Stool-softening effect and action mechanism of free anthraquinones extracted from Rheum palmatum L. on water deficit-induced constipation in rats. Journal of ethnopharmacology. 2023 Oct; 319(Pt 3):117336. doi: 10.1016/j.jep.2023.117336. [PMID: 37907143]
  • Zebu Song, Yang Chen, Hao Chang, Yanchen Guo, Qi Gao, Zhi Wei, Lang Gong, Guihong Zhang, ZeZhong Zheng. Rhein suppresses African swine fever virus replication in vitro via activating the caspase-dependent mitochondrial apoptosis pathway. Virus research. 2023 Oct; ?(?):199238. doi: 10.1016/j.virusres.2023.199238. [PMID: 37827302]
  • Xi Mao, Ding-Qiao Xu, Shi-Jun Yue, Rui-Jia Fu, Sai Zhang, Yu-Ping Tang. Potential Medicinal Value of Rhein for Diabetic Kidney Disease. Chinese journal of integrative medicine. 2023 Oct; 29(10):951-960. doi: 10.1007/s11655-022-3591-y. [PMID: 36607584]
  • Hua Liu, Tian-Ai Zhang, Wen-Yue Zhang, Si-Rui Huang, Yue Hu, Jia Sun. Rhein attenuates cerebral ischemia-reperfusion injury via inhibition of ferroptosis through NRF2/SLC7A11/GPX4 pathway. Experimental neurology. 2023 Sep; ?(?):114541. doi: 10.1016/j.expneurol.2023.114541. [PMID: 37714424]
  • Pablo Zambrano, Malgorzata Jemiola-Rzeminska, Diego Muñoz-Torrero, Mario Suwalsky, Kazimierz Strzalka. A rhein-huprine hybrid protects erythrocyte membrane integrity against Alzheimer's disease related Aβ(1-42) peptide. Biophysical chemistry. 2023 09; 300(?):107061. doi: 10.1016/j.bpc.2023.107061. [PMID: 37307659]
  • Yahui Hu, Shasha He, Xiaolong Xu, Xuran Cui, Yiming Wei, Chunxia Zhao, Haoran Ye, Jingxia Zhao, Qingquan Liu. Shenhuangdan decoction alleviates sepsis-induced lung injury through inhibition of GSDMD-mediated pyroptosis. Journal of ethnopharmacology. 2023 Aug; 318(Pt B):117047. doi: 10.1016/j.jep.2023.117047. [PMID: 37586442]
  • ShengHao Chen, YanLan Liang, YuanYuan Li, Yue Sun, Yang He. Determination of rhein and physcion in rhubarb by microchip capillary electrophoresis in mixed hydro-organic solvent combined with laser-induced fluorescence detection. Journal of separation science. 2023 Jul; ?(?):e2300192. doi: 10.1002/jssc.202300192. [PMID: 37507831]
  • Fei Cao, Jie Xiang, Yaodong Wang, Xijie Chen, Xirong Lu, Xingmeng Xu, Lin Chen, Yinghong Fan, Chenchen Yuan, Xiaowu Dong, Qingtian Zhu, Chenxia Han, Guotao Lu, Qing Xia, Weiwei Chen. Chaiqin chengqi decoction alleviates acute pancreatitis by targeting gasdermin D-mediated pyroptosis. Journal of ethnopharmacology. 2023 Jul; 318(Pt A):116920. doi: 10.1016/j.jep.2023.116920. [PMID: 37480969]
  • Jianhang Bao, Wenshuo Gao, Wei Zhang, Dong Wang, Hao Pan. Fibrin glue delivery system containing rhein ameliorates intervertebral disc degeneration by anti-inflammatory efficacy. Journal of orthopaedic surgery and research. 2023 Jul; 18(1):485. doi: 10.1186/s13018-023-03961-9. [PMID: 37415165]
  • Yudan Mei, Xiaoyu Tong, Yumei Hu, Wenjun Liu, Jiajia Wang, Kaihong Lv, Xu Li, Liang Cao, Zhenzhong Wang, Wei Xiao, Xia Gao. Comparative pharmacokinetics of six bioactive components of Shen-Wu-Yi-Shen tablets in normal and chronic renal failure rats based on UPLC-TSQ-MS/MS. Journal of ethnopharmacology. 2023 Jun; 317(?):116818. doi: 10.1016/j.jep.2023.116818. [PMID: 37348793]
  • Xinqiu Li, Zixiang Lin, Penglong Wang, Chaoyu Zhou, Jiawei Xu, Jiahao Lin, Degui Lin, Di Zhang. Tetramethylpyrazine-Rhein Derivative inhibits the migration of canine inflammatory mammary carcinoma cells by mitochondrial damage-mediated apoptosis and cadherins downregulation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jun; 162(?):114731. doi: 10.1016/j.biopha.2023.114731. [PMID: 37086510]
  • H Wang, M Li, S Li, J Shi, L Huang, S Cheng, C Zou, H Yan. [Spectrum-effect relationship of total anthraquinone extract of Cassia seeds against fluorouracil-induced liver injury in mice]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2023 May; 43(5):825-831. doi: 10.12122/j.issn.1673-4254.2023.05.19. [PMID: 37313825]
  • Haibo Zhang, Lei Ma, Eungyung Kim, Junkoo Yi, Hai Huang, Hyeonjin Kim, Muhammad Atif Raza, Sijun Park, Soyoung Jang, Kirim Kim, Sung-Hyun Kim, Youngkyun Lee, Eunkyong Kim, Zae Young Ryoo, Myoung Ok Kim. Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108507. [PMID: 37239855]
  • Song Liu, Lei Shu, Jiayao Yang, Yi Liu, Shu Zhang, Nian Wang, Zhaohong Shi. Rhein Exhibits Anti-Inflammatory Effects in Chronic Atrophic Gastritis via Nrf2 and MAPK Signaling. The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology. 2023 05; 34(5):525-532. doi: 10.5152/tjg.2023.22251. [PMID: 36789982]
  • Si Li, Xi Wu, Yue Ma, Hua Zhang, Wen Chen. Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology. Journal of ethnopharmacology. 2023 Apr; ?(?):116435. doi: 10.1016/j.jep.2023.116435. [PMID: 37023836]
  • Fan Wu, Ting Zhao, Yu Zhang, Yan Wang, Guoxin Liao, Baojing Zhang, Chao Wang, Xiangge Tian, Lei Feng, Bangjiang Fang, Xiaokui Huo, Xiaochi Ma. Beneficial herb-drug interaction of rhein in Jinhongtang and Imipenem/Cilastatin mediated by organic anion transporters. Journal of ethnopharmacology. 2023 Apr; ?(?):116449. doi: 10.1016/j.jep.2023.116449. [PMID: 37023835]
  • Fan Wu, Yan Wang, Quanxi Mei, Qinhua Chen, Chengpeng Sun, Xia Lv, Lei Feng, Chao Wang, Yanyan Zhang, Bangjiang Fang, Xiaokui Huo, Xiangge Tian, Xiaochi Ma. UGTs-mediated metabolic interactions contribute to enhanced anti-inflammation activity of Jinhongtang. Journal of ethnopharmacology. 2023 Mar; 304(?):116016. doi: 10.1016/j.jep.2022.116016. [PMID: 36535328]
  • Dongpeng Wang, Jufeng Duan, Xiao-Jing Chen, Kaiqi Liu, Yingying Guo, Run Shi, Sha Li, Ming Liu, Lijun Zhao, Bei Li, Hongtao Liu, Minglun Li, Yibin Feng, Hongliang Li, Xuanbin Wang. Pharmacokinetic characteristics of emodin in polygoni Multiflori Radix Praeparata. Journal of ethnopharmacology. 2023 Mar; 303(?):115945. doi: 10.1016/j.jep.2022.115945. [PMID: 36435407]
  • Wenting Su, Congyan Liu, Xi Jiang, Yanli Lv, Qin Chen, Jiachen Shi, Huangqin Zhang, Qiuling Ma, Chang Ge, Fei Kong, Xiaoqi Li, Yuping Liu, Yan Chen, Ding Qu. An intravitreal-injectable hydrogel depot doped borneol-decorated dual-drug-coloaded microemulsions for long-lasting retina delivery and synergistic therapy of wAMD. Journal of nanobiotechnology. 2023 Mar; 21(1):71. doi: 10.1186/s12951-023-01829-y. [PMID: 36859261]
  • Shunshun Chen, Meimei Wang, Linhua Yu, Jinchao Shi, Yong Zhang, Yao Tian, Li Li, Xiang Zhu, Junkai Li. Rhein-Amino Acid Ester Conjugates as Potential Antifungal Agents: Synthesis and Biological Evaluation. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052074. [PMID: 36903319]
  • Lingling Wang, Guoying Zhou, Shuo Zhao, Yang Yang. Soluble protein content, bioactive compounds and the antioxidant activity in seeds of ten Rheum tanguticum lines from Qinghai-Tibet Plateau. Chemistry & biodiversity. 2023 Feb; ?(?):e202200901. doi: 10.1002/cbdv.202200901. [PMID: 36788177]
  • Chuankui Fu, Yiheng Zhang, Wen Jie Xi, Kejia Xu, Fansheng Meng, Tianle Ma, Weidong Li, Li Wu, Zhipeng Chen. Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway. Journal of ethnopharmacology. 2023 Jan; 308(?):116191. doi: 10.1016/j.jep.2023.116191. [PMID: 36731809]
  • Qili Wang, Shunping Han, Yongqin Zhu, Guowei Wang, Danfei Chen. Poly-γ-glutamic acid coating polymeric nanoparticles enhance renal drug distribution and cellular uptake for diabetic nephropathy therapy. Journal of drug targeting. 2023 01; 31(1):89-99. doi: 10.1080/1061186x.2022.2106488. [PMID: 35880399]
  • Jijia Sun, Qinghua Ni, Fengyan Jiang, Baocheng Liu, Jianying Wang, Lei Zhang, Jihan Huang. Discovery and Validation of Traditional Chinese and Western Medicine Combination Antirheumatoid Arthritis Drugs Based on Machine Learning (Random Forest Model). BioMed research international. 2023; 2023(?):6086388. doi: 10.1155/2023/6086388. [PMID: 36845640]
  • Heba M K Ebada, Maha M A Nasra, Rasha A Nassra, Ossama Y Abdallah. Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment. Drug delivery. 2022 Dec; 29(1):652-663. doi: 10.1080/10717544.2022.2041130. [PMID: 35188017]
  • Shanshan Qi, Ruifeng Luo, Xiaoqin Han, Wenbiao Nie, Naijing Ye, Chaomei Fu, Fei Gao. pH/ROS Dual-Sensitive Natural Polysaccharide Nanoparticles Enhance "One Stone Four Birds" Effect of Rhein on Ulcerative Colitis. ACS applied materials & interfaces. 2022 Nov; 14(45):50692-50709. doi: 10.1021/acsami.2c17827. [PMID: 36326017]
  • Ya Zhao, Jinqiu Wang, Lijuan Liu, Yayun Wu, Qiaohong Hu, Ruizhi Zhao. Vinegar-baked Radix Bupleuri enhances the liver-targeting effect of rhein on liver injury rats by regulating transporters. The Journal of pharmacy and pharmacology. 2022 Nov; 74(11):1588-1597. doi: 10.1093/jpp/rgac062. [PMID: 36181768]
  • Yanna Zhu, Shilei Yang, Linlin Lv, Xiaohan Zhai, Guoyu Wu, Xiaolin Qi, Deshi Dong, Xufeng Tao. Research Progress on the Positive and Negative Regulatory Effects of Rhein on the Kidney: A Review of Its Molecular Targets. Molecules (Basel, Switzerland). 2022 Oct; 27(19):. doi: 10.3390/molecules27196572. [PMID: 36235108]
  • Ning Xu, Yuanran Chen, Dongjie Guo, Yu Deng, Wanjun Guo, Xin Liu, Yi Wang, Hanzhi Lu, Aijun Liu, Jianyong Zhu, Fulun Li. Rhein promotes the proliferation of keratinocytes by targeting oestrogen receptors for skin ulcer treatment. BMC complementary medicine and therapies. 2022 Aug; 22(1):209. doi: 10.1186/s12906-022-03691-1. [PMID: 35932049]
  • Veronica Folliero, Federica Dell'Annunziata, Emanuela Roscetto, Alessandra Amato, Roberta Gasparro, Carla Zannella, Vincenzo Casolaro, Anna De Filippis, Maria Rosaria Catania, Gianluigi Franci, Massimiliano Galdiero. Rhein: A novel antibacterial compound against Streptococcus mutans infection. Microbiological research. 2022 Aug; 261(?):127062. doi: 10.1016/j.micres.2022.127062. [PMID: 35597077]
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