Methoxsalen (BioDeep_00000398586)

natural product PANOMIX_OTCML-2023

代谢物信息卡片

8-Methoxypsoralen

化学式: C12H8O4 (216.0422568)
中文名称: 花椒毒素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
InChI: InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3

描述信息

D - Dermatologicals > D05 - Antipsoriatics > D05B - Antipsoriatics for systemic use > D05BA - Psoralens for systemic use
D - Dermatologicals > D05 - Antipsoriatics > D05A - Antipsoriatics for topical use > D05AD - Psoralens for topical use
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.910
C1420 - Photosensitizing Agent
D003879 - Dermatologic Agents
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.909
Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.
Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

同义名列表

4 个代谢物同义名

Methoxsalen; 8-Methoxypsoralen; Xanthotoxin; 8-MOP

数据库引用编号

22 个数据库交叉引用编号

ChEBI: CHEBI:18358
KEGG: C01864
PubChem: 4114
DrugBank: DB00553
ChEMBL: CHEMBL416
MeSH: Methoxsalen
CAS: 298-81-7
CAS: 1246819-63-5
CAS: 12692-94-3
MoNA: Bruker_HCD_library001322
MoNA: PM014605
MoNA: BML80647
MoNA: BML80645
MoNA: BML00979
MoNA: BML00970
MoNA: BML00961
PubChem: 4978
KNApSAcK: C00000576
PDB-CCD: 8MO
3DMET: B00362
NIKKAJI: J2.983A
medchemexpress: HY-30151

分类词条

苯丙素类

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

234 个相关的物种来源信息

155265 Sideritis syriaca: 10.1016/S0378-8741(02)00172-1
155266 Sideritis taurica: 10.1016/S0378-8741(02)00172-1
3702 Arabidopsis thaliana: 10.1111/TPJ.14311
48101 Angelica dahurica:
2099548 Zanthoxylum zanthoxyloides: 10.1021/NP50046A035
681593 Niphogeton ternata: 10.1248/CPB.50.115
380073 Heracleum dissectum:
354521 Tetradium daniellii:
626692 Caragana spinosa: 10.1007/S10600-012-0124-5
4577 Zea mays: 10.1007/BF00391272
159034 Clausena anisata:
1136744 Esenbeckia berlandieri: 10.1016/S0305-1978(01)00138-7
49563 Peucedanum japonicum:
265806 Angelica japonica:
1108177 Campylotropis hirtella: 10.1248/CPB.56.1338
1331801 Metrodorea flavida:
312530 Angelica pubescens:
948492 Pleurospermum rivulorum: 10.1016/S0031-9422(97)00123-4
325744 Prangos uloptera:
1585705 Prangos lipskyi: 10.1007/BF00570686
558542 Feroniella lucida: 10.1080/10286020.2011.572878
48119 Glehnia littoralis:
231460 Afraegle paniculata: 10.1080/15287398409530517
1585712 Prangos tschimganica:
48026 Ammi majus:
282648 Asterolasia phebalioides: 10.1016/0305-1978(94)90036-1
354492 Dinosperma melanophloium: 10.1016/S0305-1978(97)00116-6
681588 Magydaris pastinacea: 10.1021/NP50050A046
159030 Murraya koenigii: 10.1016/S0367-326X(99)00163-X
357850 Angelica keiskei:
380075 Heracleum grandiflorum:
549427 Metrodorea nigra: 10.1016/0031-9422(95)00504-Z
996940 Heracleum moellendorffii var. paucivittatum: 10.1007/BF00600845
380077 Heracleum mantegazzianum:
380076 Heracleum leskovii: 10.1007/BF01134615
452763 Boenninghausenia albiflora:
159053 Limonia acidissima:
452800 Thamnosma texana: 10.1016/S0031-9422(00)80348-9
489434 Prangos ferulacea: 10.1590/S0102-695X2008000100002
282633 Phebalium squamulosum: 10.1016/0031-9422(92)83450-D
2749842 Leionema ambiens: 10.1016/0031-9422(92)83450-D
282630 Phebalium canaliculatum: 10.1016/0031-9422(92)83450-D
282637 Phebalium filifolium: 10.1016/0031-9422(92)83450-D
282620 Rhadinothamnus anceps:
2831629 Angelica taiwaniana:
357970 Angelica biserrata:
52477 Peucedanum ostruthium:
40949 Angelica archangelica:
85712 Angelica gigas:
357859 Angelica ursina:
282619 Rhadinothamnus rudis:
473995 Heracleum yungningense: 10.1248/CPB.53.701
549402 Esenbeckia grandiflora:
223585 Seseli tortuosum: 10.1016/S0040-4039(00)72373-2
354518 Skimmia laureola: 10.1016/S0031-9422(00)81759-8
555413 Ferula moschata: 10.1016/S0031-9422(99)00554-3
371383 Ferula sumbul: 10.1016/S0031-9422(99)00554-3
94007 Cnidium monnieri:
178647 Arracacia tolucensis: 10.1016/J.JEP.2007.05.015
203717 Saposhnikovia divaricata:
489417 Tordylium apulum: 10.1016/S0031-9422(98)00018-1
4045 Apium graveolens:
1056472 Zanthoxylum mayu:
37565 Ruta graveolens:
452790 Ruta chalepensis:
266085 Ruta montana:
4043 Petroselinum crispum:
489439 Deverra tortuosa: 10.1590/S0103-50532003000100008
203712 Peucedanum officinale: 10.1007/BF02066241
40919 Heracleum sphondylium:
380072 Heracleum asperum: 10.1007/BF00563460
376867 Heracleum ponticum: 10.1007/BF00563460
99507 Heracleum moellendorffii: 10.1007/BF00563460
549423 Hortia oreadica: 10.3390/MOLECULES190812031
68527 Aegle marmelos: 10.1590/S0103-50532011000100024
40918 Heracleum maximum:
4039 Daucus carota:
271192 Pimpinella anisum:
4041 Pastinaca sativa:
354508 Phellodendron chinense: 10.1139/B91-065
53836 Bituminaria bituminosa: 10.1139/B91-212
429560 Cullen corylifolium: 10.1139/B91-212
100167 Psoralea: 10.1139/B91-212
1898452 Trichocline caulescens: 10.1016/S0031-9422(00)98112-3
714465 Dictamnus dasycarpus:
4047 Coriandrum sativum: 10.1016/S0031-9422(00)81503-4
48032 Carum carvi: 10.1016/S0031-9422(00)81503-4
40888 Anthriscus cerefolium: 10.1016/S0031-9422(00)81503-4
40922 Anethum graveolens: 10.1016/S0031-9422(00)81503-4
48042 Levisticum officinale: 10.1016/S0031-9422(00)81503-4
52462 Cuminum cyminum: 10.1016/S0031-9422(00)81503-4
159026 Atalantia racemosa:
273128 Acronychia baeuerlenii: 10.1016/S0305-1978(96)00067-1
354507 Orixa japonica:
223582 Seseli longifolium: 10.1016/0031-9422(88)80276-0
54833 Seseli elatum: 10.1016/0031-9422(88)80276-0
37564 Ruta: 10.1007/BF01016480
298346 Dictamnus albus: 10.1007/BF00579494
1053409 Ammi visnaga: 10.1021/NP50039A030
354526 Zanthoxylum americanum:
55605 Angelica acutiloba: 10.1021/JF0497049
491192 Tordyliopsis brunonis: 10.1021/NP50053A050
37690 Citrus trifoliata: 10.1271/BBB.80859
452794 Ruta pinnata: 10.1139/B93-109
318024 Notobubon galbanum: 10.1016/S0254-6299(16)30778-5
489364 Diplotaenia damavandica: 10.1076/PHBI.37.2.161.6080
2831630 Angelica tarokoensis: 10.1002/JCCS.197000012
159062 Pamburus missionis: 10.1016/S0031-9422(00)90455-2
405848 Psilopeganum sinense: 10.1016/0305-1978(88)90011-7
489421 Cachrys sicula: 10.1016/S0031-9422(00)85511-9
210365 Skimmia japonica: 10.1055/S-2006-962141
2896591 Stauranthus perforatus:
3908 Vicia sativa: 10.1007/BF00598366
76951 Atalantia ceylanica:
47643 Caragana frutex: 10.1007/BF00575186
452791 Ruta corsica: 10.1016/J.FITOTE.2003.12.014
155265 Sideritis syriaca: 10.1016/S0378-8741(02)00172-1
155266 Sideritis taurica: 10.1016/S0378-8741(02)00172-1
3702 Arabidopsis thaliana: 10.1111/TPJ.14311
48101 Angelica dahurica:
2099548 Zanthoxylum zanthoxyloides: 10.1021/NP50046A035
681593 Niphogeton ternata: 10.1248/CPB.50.115
380073 Heracleum dissectum:
354521 Tetradium daniellii:
626692 Caragana spinosa: 10.1007/S10600-012-0124-5
4577 Zea mays: 10.1007/BF00391272
159034 Clausena anisata:
1136744 Esenbeckia berlandieri: 10.1016/S0305-1978(01)00138-7
49563 Peucedanum japonicum:
265806 Angelica japonica:
1108177 Campylotropis hirtella: 10.1248/CPB.56.1338
1331801 Metrodorea flavida:
312530 Angelica pubescens:
948492 Pleurospermum rivulorum: 10.1016/S0031-9422(97)00123-4
325744 Prangos uloptera:
1585705 Prangos lipskyi: 10.1007/BF00570686
558542 Feroniella lucida: 10.1080/10286020.2011.572878
48119 Glehnia littoralis:
231460 Afraegle paniculata: 10.1080/15287398409530517
1585712 Prangos tschimganica:
48026 Ammi majus:
282648 Asterolasia phebalioides: 10.1016/0305-1978(94)90036-1
354492 Dinosperma melanophloium: 10.1016/S0305-1978(97)00116-6
681588 Magydaris pastinacea: 10.1021/NP50050A046
159030 Murraya koenigii: 10.1016/S0367-326X(99)00163-X
357850 Angelica keiskei:
380075 Heracleum grandiflorum:
549427 Metrodorea nigra: 10.1016/0031-9422(95)00504-Z
996940 Heracleum moellendorffii var. paucivittatum: 10.1007/BF00600845
380077 Heracleum mantegazzianum:
380076 Heracleum leskovii: 10.1007/BF01134615
452763 Boenninghausenia albiflora:
159053 Limonia acidissima:
452800 Thamnosma texana: 10.1016/S0031-9422(00)80348-9
489434 Prangos ferulacea: 10.1590/S0102-695X2008000100002
282633 Phebalium squamulosum: 10.1016/0031-9422(92)83450-D
2749842 Leionema ambiens: 10.1016/0031-9422(92)83450-D
282630 Phebalium canaliculatum: 10.1016/0031-9422(92)83450-D
282637 Phebalium filifolium: 10.1016/0031-9422(92)83450-D
282620 Rhadinothamnus anceps:
2831629 Angelica taiwaniana:
357970 Angelica biserrata:
52477 Peucedanum ostruthium:
40949 Angelica archangelica:
85712 Angelica gigas:
357859 Angelica ursina:
282619 Rhadinothamnus rudis:
473995 Heracleum yungningense: 10.1248/CPB.53.701
549402 Esenbeckia grandiflora:
223585 Seseli tortuosum: 10.1016/S0040-4039(00)72373-2
354518 Skimmia laureola: 10.1016/S0031-9422(00)81759-8
555413 Ferula moschata: 10.1016/S0031-9422(99)00554-3
371383 Ferula sumbul: 10.1016/S0031-9422(99)00554-3
94007 Cnidium monnieri:
178647 Arracacia tolucensis: 10.1016/J.JEP.2007.05.015
203717 Saposhnikovia divaricata:
489417 Tordylium apulum: 10.1016/S0031-9422(98)00018-1
4045 Apium graveolens:
1056472 Zanthoxylum mayu:
37565 Ruta graveolens:
452790 Ruta chalepensis:
266085 Ruta montana:
4043 Petroselinum crispum:
489439 Deverra tortuosa: 10.1590/S0103-50532003000100008
203712 Peucedanum officinale: 10.1007/BF02066241
40919 Heracleum sphondylium:
380072 Heracleum asperum: 10.1007/BF00563460
376867 Heracleum ponticum: 10.1007/BF00563460
99507 Heracleum moellendorffii: 10.1007/BF00563460
549423 Hortia oreadica: 10.3390/MOLECULES190812031
68527 Aegle marmelos: 10.1590/S0103-50532011000100024
40918 Heracleum maximum:
4039 Daucus carota:
271192 Pimpinella anisum:
4041 Pastinaca sativa:
354508 Phellodendron chinense: 10.1139/B91-065
53836 Bituminaria bituminosa: 10.1139/B91-212
429560 Cullen corylifolium: 10.1139/B91-212
100167 Psoralea: 10.1139/B91-212
1898452 Trichocline caulescens: 10.1016/S0031-9422(00)98112-3
714465 Dictamnus dasycarpus:
4047 Coriandrum sativum: 10.1016/S0031-9422(00)81503-4
48032 Carum carvi: 10.1016/S0031-9422(00)81503-4
40888 Anthriscus cerefolium: 10.1016/S0031-9422(00)81503-4
40922 Anethum graveolens: 10.1016/S0031-9422(00)81503-4
48042 Levisticum officinale: 10.1016/S0031-9422(00)81503-4
52462 Cuminum cyminum: 10.1016/S0031-9422(00)81503-4
159026 Atalantia racemosa:
273128 Acronychia baeuerlenii: 10.1016/S0305-1978(96)00067-1
354507 Orixa japonica:
223582 Seseli longifolium: 10.1016/0031-9422(88)80276-0
54833 Seseli elatum: 10.1016/0031-9422(88)80276-0
37564 Ruta: 10.1007/BF01016480
298346 Dictamnus albus: 10.1007/BF00579494
1053409 Ammi visnaga: 10.1021/NP50039A030
354526 Zanthoxylum americanum:
55605 Angelica acutiloba: 10.1021/JF0497049
491192 Tordyliopsis brunonis: 10.1021/NP50053A050
37690 Citrus trifoliata: 10.1271/BBB.80859
452794 Ruta pinnata: 10.1139/B93-109
318024 Notobubon galbanum: 10.1016/S0254-6299(16)30778-5
489364 Diplotaenia damavandica: 10.1076/PHBI.37.2.161.6080
2831630 Angelica tarokoensis: 10.1002/JCCS.197000012
159062 Pamburus missionis: 10.1016/S0031-9422(00)90455-2
405848 Psilopeganum sinense: 10.1016/0305-1978(88)90011-7
489421 Cachrys sicula: 10.1016/S0031-9422(00)85511-9
210365 Skimmia japonica: 10.1055/S-2006-962141
2896591 Stauranthus perforatus:
3908 Vicia sativa: 10.1007/BF00598366
76951 Atalantia ceylanica:
47643 Caragana frutex: 10.1007/BF00575186
452791 Ruta corsica: 10.1016/J.FITOTE.2003.12.014
312530 Angelica pubescens Maxim.f. biserata Shan et Yuan: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Oleg A Kulikov, Vasilisa I Shlyapkina, Ekaterina P Brodovskaya, Amina M Al-Khadj Aioub, Valentin P Ageev, Mikhail N Zharkov, Denis E Yakobson, Daniil S Sokushev, Nikolay A Pyataev, Gleb B Sukhorukov. Phototoxicity in vitro and safety in vivo of the emulsion photosensitizer based on furanocoumarins of Heracleum sosnowskyi. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 May; 198(?):114257. doi: 10.1016/j.ejpb.2024.114257. [PMID: 38479564]
Kasemsiri Chandarajoti, Jiraporn Kara, Paptawan Suwanhom, Teerapat Nualnoi, Jindaporn Puripattanavong, Vannajan Sanghiran Lee, Varomyalin Tipmanee, Luelak Lomlim. Synthesis and evaluation of coumarin derivatives on antioxidative, tyrosinase inhibitory activities, melanogenesis, and in silico investigations. Scientific reports. 2024 03; 14(1):5535. doi: 10.1038/s41598-024-54665-x. [PMID: 38448547]
Tianxiang Xiao, Zhiming Yang, Wenxiu Wang, Mengqing Deng, Haoxue Peng, Zifan Huang, Jianping Liu, Kai Lu. Role of the epsilon glutathione S-transferases in xanthotoxin tolerance in Spodoptera litura. Pesticide biochemistry and physiology. 2023 Nov; 196(?):105592. doi: 10.1016/j.pestbp.2023.105592. [PMID: 37945225]
Jia Lai, Yueyue Li, Mei Ran, Qianqian Huang, Feihong Huang, Linjie Zhu, Yuesong Wu, Wenjun Zou, Xiang Xie, Yong Tang, Fei Yang, Anguo Wu, Guangbo Ge, Jianming Wu. Xanthotoxin, a novel inducer of platelet formation, promotes thrombocytopoiesis via IL-1R1 and MEK/ERK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114811. doi: 10.1016/j.biopha.2023.114811. [PMID: 37156117]
Zhiming Yang, Tianxiang Xiao, Mengqing Deng, Wenxiu Wang, Haoxue Peng, Kai Lu. Nuclear receptors potentially regulate phytochemical detoxification in Spodoptera litura. Pesticide biochemistry and physiology. 2023 May; 192(?):105417. doi: 10.1016/j.pestbp.2023.105417. [PMID: 37105640]
César Sotelo-Leyva, Dante Avilés-Montes, Juan Manuel Rivas-González, Rodolfo Figueroa-Brito, Rodolfo Abarca-Vargas, Erubiel Toledo-Hernández, David Osvaldo Salinas-Sánchez. Xanthotoxin: an aphicidal coumarin from Ficus petiolaris against Melanaphis sacchari Zehntner (Hemiptera: Aphididae). Journal of food protection. 2023 Apr; ?(?):100084. doi: 10.1016/j.jfp.2023.100084. [PMID: 37019182]
Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica. Journal of natural products. 2023 01; 86(1):138-148. doi: 10.1021/acs.jnatprod.2c00844. [PMID: 36529937]
Jun-Fang Wu, Ablajan Turak, Deng Zang, Guo-An Zou, Haji Akber Aisa. Sesquiterpenoids from Seriphidium transiliense and Their Melanogenic Activity. Journal of natural products. 2022 11; 85(11):2570-2582. doi: 10.1021/acs.jnatprod.2c00527. [PMID: 36326734]
Anxin Wu, Jing Lu, Guofeng Zhong, Ling Lu, Yan Qu, Chen Zhang. Xanthotoxin (8-methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity. Phytotherapy research : PTR. 2022 Oct; 36(10):3805-3832. doi: 10.1002/ptr.7577. [PMID: 35913174]
Noura S Dosoky, Prabodh Satyal, William N Setzer. Authentication of Citrus spp. Cold-Pressed Essential Oils by Their Oxygenated Heterocyclic Components. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196277. [PMID: 36234812]
Kriti Juneja, Till Beuerle, Debabrata Sircar. Enhanced Accumulation of Biologically Active Coumarin and Furanocoumarins in Callus Culture and Field-grown Plants of Ruta chalepensis Through LED Light-treatment. Photochemistry and photobiology. 2022 09; 98(5):1100-1109. doi: 10.1111/php.13610. [PMID: 35191044]
Huan Shi, Ya-Qing Chang, Xie Feng, Gui-Ya Yang, Yu-Guang Zheng, Qian Zheng, Lan-Lan Zhang, Dan Zhang, Long Guo. Chemical comparison and discrimination of two plant sources of Angelicae dahuricae Radix, Angelica dahurica and Angelica dahurica var. formosana, by HPLC-Q/TOF-MS and quantitative analysis of multiple components by a single marker. Phytochemical analysis : PCA. 2022 Jul; 33(5):776-791. doi: 10.1002/pca.3129. [PMID: 35470493]
Yu Shi, Shuo Sun, Yujun Zhang, Yingshi He, Minghong Du, Andrias O ÓReilly, Shuwen Wu, Yihua Yang, Yidong Wu. Single amino acid variations drive functional divergence of cytochrome P450s in Helicoverpa species. Insect biochemistry and molecular biology. 2022 07; 146(?):103796. doi: 10.1016/j.ibmb.2022.103796. [PMID: 35636594]
Shaohang Yuan, Zhiguang Yang, Changjiao Shang, Danyang Yang, Yuxuan Wang, Haifei Qi, Chaofan Sun, Lingling Wang, Xiuhua Zhao. A DFT study on the structure activity relationship of the natural xanthotoxin-based pharmaceutical cocrystals. Journal of molecular modeling. 2022 May; 28(6):155. doi: 10.1007/s00894-022-05152-5. [PMID: 35579707]
Oleg A Kulikov, Valentin P Ageev, Ekaterina P Brodovskaya, Vasilisa I Shlyapkina, Pavel S Petrov, Mikhail N Zharkov, Denis E Yakobson, Igor V Maev, Gleb B Sukhorukov, Nikolay A Pyataev. Evaluation of photocytotoxicity liposomal form of furanocoumarins Sosnowsky's hogweed. Chemico-biological interactions. 2022 Apr; 357(?):109880. doi: 10.1016/j.cbi.2022.109880. [PMID: 35271822]
Marwa Y Issa, Mohamed F Elshal, Noha Fathallah, Mostafa A Abdelkawy, Mokhtar Bishr, Osama Salama, Yasmin S Abulfadl. Potential Anticancer Activity of the Furanocoumarin Derivative Xanthotoxin Isolated from Ammi majus L. Fruits: In Vitro and In Silico Studies. Molecules (Basel, Switzerland). 2022 Jan; 27(3):. doi: 10.3390/molecules27030943. [PMID: 35164207]
Maria Magdalena Quetglas-Llabrés, Cristina Quispe, Jesús Herrera-Bravo, Marcelo D Catarino, Olívia R Pereira, Susana M Cardoso, Kamal Dua, Dinesh Kumar Chellappan, Kavita Pabreja, Saurabh Satija, Meenu Mehta, Antoni Sureda, Miquel Martorell, Dinara Satmbekova, Balakyz Yeskaliyeva, Javad Sharifi-Rad, Naeem Rasool, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu, Daniela Calina, William C Cho. Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects. Oxidative medicine and cellular longevity. 2022; 2022(?):8615242. doi: 10.1155/2022/8615242. [PMID: 35509838]
Kan Fu, Jianchun Zhang, Lanying Wang, Xu Zhao, Yanping Luo. Xanthotoxin induced photoactivated toxicity, oxidative stress and cellular apoptosis in Caenorhabditis elegans under ultraviolet A. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Jan; 251(?):109217. doi: 10.1016/j.cbpc.2021.109217. [PMID: 34673249]
Youdan Liang, Long Xie, Kai Liu, Yi Cao, Xiaolin Dai, Xian Wang, Jing Lu, Xumin Zhang, Xiaofang Li. Bergapten: A review of its pharmacology, pharmacokinetics, and toxicity. Phytotherapy research : PTR. 2021 Nov; 35(11):6131-6147. doi: 10.1002/ptr.7221. [PMID: 34347307]
Viola Hähnel, Andreas-Michael Brosig, Martin Ehrenschwender, Ralph Burkhardt, Robert Offner, Norbert Ahrens. Apoptosis induction by extracorporeal photopheresis is enhanced by increasing the 8-methoxypsoralen concentration and by replacing plasma with saline. Transfusion. 2021 10; 61(10):2991-2999. doi: 10.1111/trf.16634. [PMID: 34427336]
Laina Zarisa Mohd Kamal, Mowaffaq Adam Ahmed Adam, Siti Nurfatimah Mohd Shahpudin, Ahmad Naqeeb Shuib, Rosline Sandai, Norazian Mohd Hassan, Yasser Tabana, Dayang Fredalina Basri, Leslie Thian Lung Than, Doblin Sandai. Identification of Alkaloid Compounds Arborinine and Graveoline from Ruta angustifolia (L.) Pers for their Antifungal Potential against Isocitrate lyase (ICL1) gene of Candida albicans. Mycopathologia. 2021 May; 186(2):221-236. doi: 10.1007/s11046-020-00523-z. [PMID: 33550536]
Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Wozniak, Barbara Budzynska. Xanthotoxin affects depression-related behavior and neurotransmitters content in a sex-dependent manner in mice. Behavioural brain research. 2021 02; 399(?):112985. doi: 10.1016/j.bbr.2020.112985. [PMID: 33144177]
Ewelina Kozioł, Krystyna Skalicka-Woźniak, Agnieszka Michalak, Katarzyna Kaszubska, Barbara Budzyńska. Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study. Pharmacological reports : PR. 2021 Feb; 73(1):122-129. doi: 10.1007/s43440-020-00136-9. [PMID: 32700246]
Merhan O Hindam, Rabab H Sayed, Krystyna Skalicka-Woźniak, Barbara Budzyńska, Nesrine S El Sayed. Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation. Phytotherapy research : PTR. 2020 Sep; 34(9):2351-2365. doi: 10.1002/ptr.6686. [PMID: 32250498]
Viola Hähnel, Isabell Weber, Simon Tuemmler, Bernhard Graf, Michael Gruber, Ralph Burkhardt, Norbert Ahrens. Matrix-dependent absorption of 8-methoxypsoralen in extracorporeal photopheresis. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2020 Aug; 19(8):1099-1103. doi: 10.1039/c9pp00378a. [PMID: 32638713]
Muhanad Elhafiz, Guolin Zhao, Mohammed Ismail, Dengqiu Xu, Debanjan Das, Sisi Fan, Nong Cheng, Bashir A Yousef, Zhenzhou Jiang, Luyong Zhang. Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 06; 1865(6):158657. doi: 10.1016/j.bbalip.2020.158657. [PMID: 32045698]
Ju Ri Ham, Ra-Yeong Choi, Hae-In Lee, Mi-Kyung Lee. Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-Induced Osteopenia and Steatosis in Rats. Molecules (Basel, Switzerland). 2020 Mar; 25(5):. doi: 10.3390/molecules25051177. [PMID: 32151025]
Muhammad Hafeez, Sisi Liu, Hafiz Kamran Yousaf, Saad Jan, Rui-Long Wang, G Mandela Fernández-Grandon, Xiaowei Li, Asim Gulzar, Bahar Ali, Muzammal Rehman, Sajjad Ali, Muhammad Fahad, Yaobin Lu, Mo Wang. RNA interference-mediated knockdown of a cytochrome P450 gene enhanced the toxicity of α-cypermethrin in xanthotoxin-fed larvae of Spodoptera exigua (Hübner). Pesticide biochemistry and physiology. 2020 Jan; 162(?):6-14. doi: 10.1016/j.pestbp.2019.07.003. [PMID: 31836055]
Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
Unwoo Kang, Ah-Reum Han, Yangkang So, Chang Hyun Jin, Seung Mok Ryu, Dongho Lee, Eun Kyoung Seo. Furanocoumarins from the Roots of Angelica dahurica with Inhibitory Activity against Intracellular Reactive Oxygen Species Accumulation. Journal of natural products. 2019 09; 82(9):2601-2607. doi: 10.1021/acs.jnatprod.9b00547. [PMID: 31464439]
Kai Lu, Yibei Cheng, Wenru Li, Hanfang Ni, Xia Chen, Yue Li, Bingjie Tang, Yimin Li, Dongmei Chen, Rensen Zeng, Yuanyuan Song. Copper-induced H2O2 accumulation confers larval tolerance to xanthotoxin by modulating CYP6B50 expression in Spodoptera litura. Pesticide biochemistry and physiology. 2019 Sep; 159(?):118-126. doi: 10.1016/j.pestbp.2019.06.004. [PMID: 31400773]
Zhongxiang Sun, Qi Shi, Qilin Li, Rumeng Wang, Cuicui Xu, Huanhuan Wang, Chunxia Ran, Yuanyuan Song, Rensen Zeng. Identification of a cytochrome P450 CYP6AB60 gene associated with tolerance to multi-plant allelochemicals from a polyphagous caterpillar tobacco cutworm (Spodoptera litura). Pesticide biochemistry and physiology. 2019 Feb; 154(?):60-66. doi: 10.1016/j.pestbp.2018.12.006. [PMID: 30765057]
Md Moshfekus Saleh-E-In, Ayan Roy, Muhammad Abdullah Al-Mansur, Choudhury Mahmood Hasan, Md Matiur Rahim, Nasim Sultana, Shamim Ahmed, Md Rabiul Islam, Johannes van Staden. Isolation and in silico prediction of potential drug-like compounds from Anethum sowa L. root extracts targeted towards cancer therapy. Computational biology and chemistry. 2019 Feb; 78(?):242-259. doi: 10.1016/j.compbiolchem.2018.11.025. [PMID: 30584950]
Marie Laulhé, Sylvie Lefebvre, Delphine Le Broc-Ryckewaert, Maxime Pierre, Aurélie Ferry, Bruno Delorme. A standardized methodical approach to characterize the influence of key parameters on the in vitro efficacy of extracorporeal photopheresis. PloS one. 2019; 14(3):e0212835. doi: 10.1371/journal.pone.0212835. [PMID: 30822323]
Guolin Zhao, Muhanad Elhafiz, Jingwei Jiang, Debanjan Das, Zhijian Li, Wang Zhou, Sisi Fan, Changling Wang, Ziqiao Yuan, Dengqiu Xu, Zhenzhou Jiang, Luyong Zhang, Tao Wang. Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicology and applied pharmacology. 2019 01; 362(?):150-158. doi: 10.1016/j.taap.2018.11.002. [PMID: 30419252]
Saeed Tavakoli, Mohammad-Reza Delnavazi, Reza Hadjiaghaee, Saeedeh Jafari-Nodooshan, Farahnaz Khalighi-Sigaroodi, Maryam Akhbari, Abbas Hadjiakhoondi, Narguess Yassa. Bioactive coumarins from the roots and fruits of Ferulago trifida Boiss., an endemic species to Iran. Natural product research. 2018 Nov; 32(22):2724-2728. doi: 10.1080/14786419.2017.1375915. [PMID: 28954543]
Olívia Moreira Sampaio, Lucas Campos Curcino Vieira, Barbara Sayuri Bellete, Beatriz King-Diaz, Blas Lotina-Hennsen, Maria Fátima das Graças Fernandes da Silva, Thiago André Moura Veiga. Evaluation of Alkaloids Isolated from Ruta graveolens as Photosynthesis Inhibitors. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102693. [PMID: 30347671]
T W Wu, R Cui, B X Zhang. [Determination of 8-methoxypsoralen in mouse plasma by high performance liquid chromatography and its application to pharmacokinetic study]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2018 Oct; 50(5):792-796. doi: NULL. [PMID: 30337737]
Ian S Pearse, Ryan Paul, Paul J Ode. Variation in Plant Defense Suppresses Herbivore Performance. Current biology : CB. 2018 06; 28(12):1981-1986.e2. doi: 10.1016/j.cub.2018.04.070. [PMID: 29887306]
Man Liao, Gengshen Song, Xiaoye Cheng, Xinpeng Diao, Yupeng Sun, Lantong Zhang. Simultaneous Determination of Six Coumarins in Rat Plasma and Metabolites Identification of Bergapten in Vitro and in Vivo. Journal of agricultural and food chemistry. 2018 May; 66(18):4602-4613. doi: 10.1021/acs.jafc.7b05637. [PMID: 29663811]
Yi Yang, Kangdi Zheng, Wenjie Mei, Yandong Wang, Chuqin Yu, Bangwei Yu, Shanbin Deng, Jinhua Hu. Anti-inflammatory and proresolution activities of bergapten isolated from the roots of Ficus hirta in an in vivo zebrafish model. Biochemical and biophysical research communications. 2018 02; 496(2):763-769. doi: 10.1016/j.bbrc.2018.01.071. [PMID: 29337062]
Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate. Identification of karanjin isolated from the Indian beech tree as a potent CYP1 enzyme inhibitor with cellular efficacy via screening of a natural product repository. MedChemComm. 2018 Feb; 9(2):371-382. doi: 10.1039/c7md00388a. [PMID: 30108931]
Camilo Soto-Argel, Diego Hidalgo, Javier Palazon, Purificación Corchete. Extracellular chromone derivatives in cell cultures of Pimpinella anisum. Influence of elicitation with methyl jasmonate and 2β-methyl cyclodextrins. Biotechnology letters. 2018 Feb; 40(2):413-418. doi: 10.1007/s10529-017-2482-3. [PMID: 29185164]
Vincenzo Sicari. Optimization of the Supercritical Carbon Dioxide Separation of Bergapten from Bergamot Essential Oil. Journal of AOAC International. 2018 Jan; 101(1):293-297. doi: 10.5740/jaoacint.17-0190. [PMID: 28762330]
Ju Ri Ham, Ra-Yeong Choi, Sung-Tae Yee, Yun-Ho Hwang, Myung-Joo Kim, Mi-Kyung Lee. Methoxsalen supplementation attenuates bone loss and inflammatory response in ovariectomized mice. Chemico-biological interactions. 2017 Dec; 278(?):135-140. doi: 10.1016/j.cbi.2017.10.014. [PMID: 29074052]
Magdalena Bartnik, Adrianna Sławińska-Brych, Aleksandra Żurek, Martyna Kandefer-Szerszeń, Barbara Zdzisińska. 8-methoxypsoralen reduces AKT phosphorylation, induces intrinsic and extrinsic apoptotic pathways, and suppresses cell growth of SK-N-AS neuroblastoma and SW620 metastatic colon cancer cells. Journal of ethnopharmacology. 2017 Jul; 207(?):19-29. doi: 10.1016/j.jep.2017.06.010. [PMID: 28627461]
Guang Xian Pang, Chao Niu, Nuramina Mamat, Haji Akber Aisa. Synthesis and in vitro biological evaluation of novel coumarin derivatives containing isoxazole moieties on melanin synthesis in B16 cells and inhibition on bacteria. Bioorganic & medicinal chemistry letters. 2017 06; 27(12):2674-2677. doi: 10.1016/j.bmcl.2017.04.039. [PMID: 28476568]
Sony George, Ramaswamy Venkataraman, Sabulal Baby. Melicodenine I, a new quinolinone alkaloid from Melicope denhamii leaves. Natural product research. 2017 Apr; 31(8):890-895. doi: 10.1080/14786419.2016.1253075. [PMID: 27817202]
Viola Hähnel, Frauke Dormann, Athanasios Nitsopoulos, Albrecht Friedle, Norbert Ahrens. A method for the quantification of 8-methoxypsoralen by mass spectrometry for offline extracorporeal photopheresis. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2017 02; 16(2):193-200. doi: 10.1039/c6pp00327c. [PMID: 27976780]
N M Kowal, R Eyjolfsson, E S Olafsdottir. Investigations on the constituents of SagaPro tablets, a food supplement manufactured from Angelica archangelica leaf. Die Pharmazie. 2017 Jan; 72(1):3-4. doi: 10.1691/ph.2017.6807. [PMID: 29441889]
Yutaka Yonezawa, Taishi Miyashita, Hiroko Ashizawa, Kazuto Hashimoto, Hiroaki Nejishima, Haruko Ogawa. Evaluation of a general toxicity study incorporating phototoxicity assessments in Sprague-Dawley rats. The Journal of toxicological sciences. 2017; 42(2):145-157. doi: 10.2131/jts.42.145. [PMID: 28321041]
Guo-Ying Zuo, Chun-Juan Wang, Jun Han, Yu-Qing Li, Gen-Chun Wang. Synergism of coumarins from the Chinese drug Zanthoxylum nitidum with antibacterial agents against methicillin-resistant Staphylococcus aureus (MRSA). Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Dec; 23(14):1814-1820. doi: 10.1016/j.phymed.2016.11.001. [PMID: 27912884]
Mirosław Zagaja, Marta Andres-Mach, Paweł Patrzylas, Daniel Pyrka, Monika Szpringer, Magdalena Florek-Łuszczki, Dorota Żółkowska, Krystyna Skalicka-Woźniak, Jarogniew J Łuszczki. Influence of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of various novel antiepileptic drugs against maximal electroshock-induced seizures in mice. Fitoterapia. 2016 Dec; 115(?):86-91. doi: 10.1016/j.fitote.2016.09.020. [PMID: 27702668]
Chao Niu, Guang Xian Pang, Gen Li, Jun Dou, Li Fei Nie, Helimay Himit, Madina Kabas, Haji Akber Aisa. Synthesis and biological evaluation of furocoumarin derivatives on melanin synthesis in murine B16 cells for the treatment of vitiligo. Bioorganic & medicinal chemistry. 2016 11; 24(22):5960-5968. doi: 10.1016/j.bmc.2016.09.056. [PMID: 27713014]
Chao Niu, Li Yin, Li Fei Nie, Jun Dou, Jiang Yu Zhao, Gen Li, Haji Akber Aisa. Synthesis and bioactivity of novel isoxazole chalcone derivatives on tyrosinase and melanin synthesis in murine B16 cells for the treatment of vitiligo. Bioorganic & medicinal chemistry. 2016 11; 24(21):5440-5448. doi: 10.1016/j.bmc.2016.08.066. [PMID: 27622747]
Qunqun Guo, Guicai Du, Hongwei He, Hongkai Xu, Daosen Guo, Ronggui Li. Two nematicidal furocoumarins from Ficus carica L. leaves and their physiological effects on pine wood nematode (Bursaphelenchus xylophilus). Natural product research. 2016 Sep; 30(17):1969-73. doi: 10.1080/14786419.2015.1094804. [PMID: 26479900]
Yi-Ping Fang, Sien-Hung Yang, Chih-Hung Lee, Ibrahim A Aljuffali, Hsiao-Ching Kao, Jia-You Fang. What is the discrepancy between drug permeation into/across intact and diseased skins? Atopic dermatitis as a model. International journal of pharmaceutics. 2016 Jan; 497(1-2):277-86. doi: 10.1016/j.ijpharm.2015.12.006. [PMID: 26657274]
Krystyna Skalicka-Woźniak, Marta Mendel, Magdalena Chłopecka, Natalia Dziekan. Isolation and evaluation of the myorelaxant effect of bergapten on isolated rat jejunum. Pharmaceutical biology. 2016; 54(1):48-54. doi: 10.3109/13880209.2015.1014570. [PMID: 25885935]
Marta Santoro, Carmela Guido, Francesca De Amicis, Diego Sisci, Erika Cione, Dolce Vincenza, Ada Donà, Maria Luisa Panno, Saveria Aquila. Bergapten induces metabolic reprogramming in breast cancer cells. Oncology reports. 2016 Jan; 35(1):568-76. doi: 10.3892/or.2015.4327. [PMID: 26459431]
Magdalena Walasek, Agnieszka Grzegorczyk, Anna Malm, Krystyna Skalicka-Woźniak. Bioactivity-guided isolation of antimicrobial coumarins from Heracleum mantegazzianum Sommier & Levier (Apiaceae) fruits by high-performance counter-current chromatography. Food chemistry. 2015 Nov; 186(?):133-8. doi: 10.1016/j.foodchem.2015.02.011. [PMID: 25976802]
Giuseppe Mancuso, Gigliola Borgonovo, Leonardo Scaglioni, Angela Bassoli. Phytochemicals from Ruta graveolens Activate TAS2R Bitter Taste Receptors and TRP Channels Involved in Gustation and Nociception. Molecules (Basel, Switzerland). 2015 Oct; 20(10):18907-22. doi: 10.3390/molecules201018907. [PMID: 26501253]
Miroslaw Zagaja, Daniel Pyrka, Krystyna Skalicka-Wozniak, Kazimierz Glowniak, Magdalena Florek-Luszczki, Michał Glensk, Jarogniew J Luszczki. Effect of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of classical antiepileptic drugs against maximal electroshock-induced seizures in mice. Fitoterapia. 2015 Sep; 105(?):1-6. doi: 10.1016/j.fitote.2015.05.020. [PMID: 26026802]
Zhi-Bin Xu, Xiao-Peng Zou, Ni Zhang, Qi-Li Feng, Si-Chun Zheng. Detoxification of insecticides, allechemicals and heavy metals by glutathione S-transferase SlGSTE1 in the gut of Spodoptera litura. Insect science. 2015 Aug; 22(4):503-11. doi: 10.1111/1744-7917.12142. [PMID: 24863567]
Meltem Erdem, Ender Büyükgüzel. THE EFFECTS OF XANTHOTOXIN ON THE BIOLOGY AND BIOCHEMISTRY OF Galleria mellonella L. (LEPIDOPTERA: PYRALIDAE). Archives of insect biochemistry and physiology. 2015 Aug; 89(4):193-203. doi: 10.1002/arch.21236. [PMID: 25821173]
Gai-Gai Deng, Xiu-Wei Yang, You-Bo Zhang, Wei Xu, Wei Wei, Tian-Li Chen. [Chemical constituents from lipophilic parts in roots of Angelica dahurica var. formosana cv. Chuanbaizhi]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jun; 40(11):2148-56. doi: . [PMID: 26552172]
Rui-Long Wang, Qing-Qing Xia, Scott R Baerson, Yong Ren, Jie Wang, Yi-Juan Su, Si-Chun Zheng, Ren-Sen Zeng. A novel cytochrome P450 CYP6AB14 gene in Spodoptera litura (Lepidoptera: Noctuidae) and its potential role in plant allelochemical detoxification. Journal of insect physiology. 2015 Apr; 75(?):54-62. doi: 10.1016/j.jinsphys.2015.02.013. [PMID: 25783953]
Rui-Long Wang, Jun Li, Christian Staehelin, Xiao-Wei Xin, Yi-Juan Su, Ren-Sen Zeng. Expression analysis of two P450 monooxygenase genes of the tobacco cutworm moth (Spodoptera litura) at different developmental stages and in response to plant allelochemicals. Journal of chemical ecology. 2015 Jan; 41(1):111-9. doi: 10.1007/s10886-014-0540-z. [PMID: 25547988]
Jin-Long Li, Li-Xin Gao, Fan-Wang Meng, Chun-Lan Tang, Ru-Jun Zhang, Jing-Ya Li, Cheng Luo, Jia Li, Wei-Min Zhao. PTP1B inhibitors from stems of Angelica keiskei (Ashitaba). Bioorganic & medicinal chemistry letters. 2015; 25(10):2028-32. doi: 10.1016/j.bmcl.2015.04.003. [PMID: 25891102]
Jing Li, Bo Ma, Qi Zhang, Xiaojing Yang, Jingjing Sun, Bowen Tang, Guangbo Cui, Di Yao, Lei Liu, Guiying Gu, Jianwei Zhu, Ping Wei, Pingkai Ouyang. Simultaneous determination of osthole, bergapten and isopimpinellin in rat plasma and tissues by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Nov; 970(?):77-85. doi: 10.1016/j.jchromb.2014.06.014. [PMID: 25240925]
Deniz Bagdas, Pretal P Muldoon, Andy Z X Zhu, Rachel F Tyndale, M Imad Damaj. Effects of methoxsalen, a CYP2A5/6 inhibitor, on nicotine dependence behaviors in mice. Neuropharmacology. 2014 Oct; 85(?):67-72. doi: 10.1016/j.neuropharm.2014.05.006. [PMID: 24859605]
Shi-Xia Huo, Xin-Ming Liu, Chun-Hui Ge, Li Gao, Xiao-Ming Peng, Ping-Ping Zhao, Ming Yan. The effects of galangin on a mouse model of vitiligo induced by hydroquinone. Phytotherapy research : PTR. 2014 Oct; 28(10):1533-8. doi: 10.1002/ptr.5161. [PMID: 24820380]
Chunni Zhang, Andrew Wong, Yalin Zhang, Xinzhi Ni, Xianchun Li. Common and unique cis-acting elements mediate xanthotoxin and flavone induction of the generalist P450 CYP321A1. Scientific reports. 2014 Sep; 4(?):6490. doi: 10.1038/srep06490. [PMID: 25262756]
Sidney J Stohs, Howard Miller, Felice Romano. Absence of furanocoumarins in Advantra Z® (Citrus aurantium, bitter orange) extracts. Journal of dietary supplements. 2014 Sep; 11(3):288-93. doi: 10.3109/19390211.2014.937047. [PMID: 25026202]
Samrat Ghosh, Kausik Bishayee, Anisur Rahman Khuda-Bukhsh. Graveoline isolated from ethanolic extract of Ruta graveolens triggers apoptosis and autophagy in skin melanoma cells: a novel apoptosis-independent autophagic signaling pathway. Phytotherapy research : PTR. 2014 Aug; 28(8):1153-62. doi: 10.1002/ptr.5107. [PMID: 24343999]
Fa He, Miao Wang, Minghuan Gao, Min Zhao, Yuhua Bai, Chunjie Zhao. Chemical composition and biological activities of Gerbera anandria. Molecules (Basel, Switzerland). 2014 Apr; 19(4):4046-57. doi: 10.3390/molecules19044046. [PMID: 24699147]
Elżbieta Radziejewska-Kubzdela, Janusz Czapski, Katarzyna Czaczyk, Róża Biegańska-Marecik. The effect of pre-treatment and modified atmosphere packaging on contents of phenolic compounds and sensory and microbiological quality of shredded celeriac. Journal of the science of food and agriculture. 2014 Apr; 94(6):1140-8. doi: 10.1002/jsfa.6381. [PMID: 24002708]
Henrique D de Menezes, Ana C Pereira, Guilherme T P Brancini, Helton Carlos de Leão, Nelson S Massola Júnior, Luciano Bachmann, Mark Wainwright, Jairo Kenupp Bastos, Gilberto U L Braga. Furocoumarins and coumarins photoinactivate Colletotrichum acutatum and Aspergillus nidulans fungi under solar radiation. Journal of photochemistry and photobiology. B, Biology. 2014 Feb; 131(?):74-83. doi: 10.1016/j.jphotobiol.2014.01.008. [PMID: 24509069]
Stefania Briganti, Enrica Flori, Barbara Bellei, Mauro Picardo. Modulation of PPARγ provides new insights in a stress induced premature senescence model. PloS one. 2014; 9(8):e104045. doi: 10.1371/journal.pone.0104045. [PMID: 25101957]
Shakir D Alsharari, Eric C K Siu, Rachel F Tyndale, Mohamad Imad Damaj. Pharmacokinetic and pharmacodynamics studies of nicotine after oral administration in mice: effects of methoxsalen, a CYP2A5/6 inhibitor. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2014 Jan; 16(1):18-25. doi: 10.1093/ntr/ntt105. [PMID: 23884323]
Christian Celia, Elena Trapasso, Marcello Locatelli, Michele Navarra, Cinzia Anna Ventura, Joy Wolfram, Maria Carafa, Valeria Maria Morittu, Domenico Britti, Luisa Di Marzio, Donatella Paolino. Anticancer activity of liposomal bergamot essential oil (BEO) on human neuroblastoma cells. Colloids and surfaces. B, Biointerfaces. 2013 Dec; 112(?):548-53. doi: 10.1016/j.colsurfb.2013.09.017. [PMID: 24099646]
Cheryl E Ainslie-Waldman, Scott W Simpkins, Pramod Upadhyaya, Steven G Carmella, Stephen S Hecht, Sabrina P Trudo. Contamination of deconjugation enzymes derived from Helix pomatia with the plant bioactive compounds 3,3'-diindolylmethane, 5-methoxypsoralen, and 8-methoxypsoralen. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Dec; 62(?):188-93. doi: 10.1016/j.fct.2013.08.055. [PMID: 23994708]
Saoussen Ben Salem, Aymen Jabrane, Fethia Harzallah-Skhiri, Hichem Ben Jannet. New bioactive dihydrofuranocoumarins from the roots of the Tunisian Ferula lutea (Poir.) Maire. Bioorganic & medicinal chemistry letters. 2013 Jul; 23(14):4248-52. doi: 10.1016/j.bmcl.2013.04.081. [PMID: 23746477]
Y Gao, Y Z Liu, X-M Zhang, Y Zhou, X Zhang, C-Y Dong. Pharmacokinetic studies of bergapten in dog plasma by using a LC-MS/MS method studies. Drug research. 2013 Jul; 63(7):338-41. doi: 10.1055/s-0033-1341426. [PMID: 23549759]
M Abu Mraheil, A Heisig, P Heisig. An improved assay for the detection of alterations in bacterial DNA supercoiling in vivo. Die Pharmazie. 2013 Jul; 68(7):541-8. doi: ". [PMID: 23923635]
Pravin O Patil, Sanjay B Bari, Sandip D Firke, Prashant K Deshmukh, Shailesh T Donda, Dilip A Patil. A comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease. Bioorganic & medicinal chemistry. 2013 May; 21(9):2434-50. doi: 10.1016/j.bmc.2013.02.017. [PMID: 23517722]
Yan-xu Chang, Qiu-Hong Zhang, Jin Li, Ling Zhang, Xin-rong Guo, Jun He, Peng Zhang, Lin Ma, Yan-ru Deng, Bo-li Zhang, Xiu-mei Gao. Simultaneous determination of scopoletin, psoralen, bergapten, xanthotoxin, columbianetin acetate, imperatorin, osthole and isoimperatorin in rat plasma by LC-MS/MS for pharmacokinetic studies following oral administration of Radix Angelicae Pubescentis extract. Journal of pharmaceutical and biomedical analysis. 2013 Apr; 77(?):71-5. doi: 10.1016/j.jpba.2012.12.031. [PMID: 23384552]
Stavros E Bariamis, Marilena Marin, Constantinos M Athanassopoulos, Christos Kontogiorgis, Zinovia Tsimali, Dionissios Papaioannou, Giovanni Sindona, Giovanni Romeo, Konstantinos Avgoustakis, Dimitra Hadjipavlou-Litina. Syntheses and evaluation of the antioxidant activity of novel methoxypsoralen derivatives. European journal of medicinal chemistry. 2013 Feb; 60(?):155-69. doi: 10.1016/j.ejmech.2012.11.043. [PMID: 23291118]
Stefania Briganti, Enrica Flori, Arianna Mastrofrancesco, Daniela Kovacs, Emanuela Camera, Matteo Ludovici, Giorgia Cardinali, Mauro Picardo. Azelaic acid reduced senescence-like phenotype in photo-irradiated human dermal fibroblasts: possible implication of PPARγ. Experimental dermatology. 2013 Jan; 22(1):41-7. doi: 10.1111/exd.12066. [PMID: 23278893]
Věra Schulzová, Luboš Babička, Jana Hajšlová. Furanocoumarins in celeriac from different farming systems: a 3-year study. Journal of the science of food and agriculture. 2012 Nov; 92(14):2849-54. doi: 10.1002/jsfa.5629. [PMID: 22407843]
Renuka Diwan, Nutan Malpathak. Effect of polyamines on shoot multiplication and furanocoumarin production in Ruta graveolens cultures. Natural product communications. 2012 Jul; 7(7):895-8. doi: ". [PMID: 22908575]
Wei-Xia Liu, Feng-Lan Jia, Yue-Ying He, Bao-Xu Zhang. Protective effects of 5-methoxypsoralen against acetaminophen-induced hepatotoxicity in mice. World journal of gastroenterology. 2012 May; 18(18):2197-202. doi: 10.3748/wjg.v18.i18.2197. [PMID: 22611312]
Katarzyna Borowska, Stanisław Wołowiec, Andrzej Rubaj, Kazimierz Głowniak, Elwira Sieniawska, Sebastian Radej. Effect of polyamidoamine dendrimer G3 and G4 on skin permeation of 8-methoxypsoralene--in vivo study. International journal of pharmaceutics. 2012 Apr; 426(1-2):280-283. doi: 10.1016/j.ijpharm.2012.01.041. [PMID: 22310461]
Krystyna Skalicka-Woźniak, Kazimierz Głowniak. Pressurized liquid extraction of coumarins from fruits of Heracleum leskowii with application of solvents with different polarity under increasing temperature. Molecules (Basel, Switzerland). 2012 Apr; 17(4):4133-41. doi: 10.3390/molecules17044133. [PMID: 22481536]
John E Casida. The greening of pesticide-environment interactions: some personal observations. Environmental health perspectives. 2012 Apr; 120(4):487-93. doi: 10.1289/ehp.1104405. [PMID: 22472325]
Guodong Niu, Henry S Pollock, Allen Lawrance, Joel P Siegel, May R Berenbaum. Effects of a naturally occurring and a synthetic synergist on toxicity of three insecticides and a phytochemical to navel orangeworm (Lepidoptera: Pyralidae). Journal of economic entomology. 2012 Apr; 105(2):410-7. doi: 10.1603/ec10194. [PMID: 22606811]
Zhigang Liu, Minyan Jiang, Xiumei Lu, Feng Qin, Yang Song, Jing Wen, Famei Li. Simultaneous determination of pimpinellin, isopimpinellin and phellopterin in rat plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of Toddalia asiatica extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Apr; 891-892(?):102-8. doi: 10.1016/j.jchromb.2012.02.022. [PMID: 22418072]
Xing Wang, Yu-Jie Lou, Ming-Xing Wang, Yun-Wei Shi, Hong-Xi Xu, Ling-Dong Kong. Furocoumarins affect hepatic cytochrome P450 and renal organic ion transporters in mice. Toxicology letters. 2012 Feb; 209(1):67-77. doi: 10.1016/j.toxlet.2011.11.030. [PMID: 22173200]
S H Ibbotson, R S Dawe, A T Dinkova-Kostova, S Weidlich, P M Farr, J Ferguson, C R Wolf, G Smith. Glutathione S-transferase genotype is associated with sensitivity to psoralen-ultraviolet A photochemotherapy. The British journal of dermatology. 2012 Feb; 166(2):380-8. doi: 10.1111/j.1365-2133.2011.10661.x. [PMID: 21967523]