Magnolol (BioDeep_00000398485)

 

Secondary id: BioDeep_00000002599, BioDeep_00000017310

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


2-(2-hydroxy-5-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol

化学式: C18H18O2 (266.1307)
中文名称: 厚朴酚
谱图信息: 最多检出来源 Viridiplantae(plant) 89.26%

分子结构信息

SMILES: C=CCc(c2)cc(c(O)c2)c(c1)c(O)ccc(CC=C)1
InChI: InChI=1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
Annotation level-1
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.
Magnolol, a natural lignan isolated from the stem bark of Magnolia officinalis, is a dual agonist of both RXRα and PPARγ, with EC50 values of 10.4 μM and 17.7 μM, respectively.

同义名列表

27 个代谢物同义名

2-(2-hydroxy-5-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol; 2-(2-hydroxy-5-prop-2-enylphenyl)-4-prop-2-enylphenol; (1,1-Biphenyl)-2,2-diol, 5,5-di-2-propenyl-; 4-allyl-2-(5-allyl-2-hydroxy-phenyl)phenol; 5,5-Di-2-propenyl-[1,1-biphenyl]-2,2-diol; 4-allyl-2-(5-allyl-2-hydroxyphenyl)phenol; 5,5-diallyl-2,2-dihydroxybiphenyl; 5,5′-Diallyl-2,2′-biphenyldiol; Dehydrodichavicol; UPCMLD-DP037:001; NCGC00161609-01; NCGC00161609-02; 2,2-Bichavicol; SMR000387108; ZINC00001645; MLS001048917; AIDS-002239; M3445_SIGMA; SMP2_000086; BB_NC-1463; NSC 293099; AIDS002239; NSC293099; Magnolol; 528-43-8; C10651; Magnolol



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

103 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 BCL2, BDNF, CASP3, CAT, EGFR, MAPK8, MTOR, NFE2L2, NOS2, PIK3CA, PPARG, PRKAA2, PTGS2, TLR4
Peripheral membrane protein 2 MTOR, PTGS2
Endosome membrane 2 EGFR, TLR4
Endoplasmic reticulum membrane 5 BCL2, EGFR, HMOX1, MTOR, PTGS2
Nucleus 10 BCL2, CASP3, EGFR, HMOX1, MAPK8, MTOR, NFE2L2, NOS2, PPARG, PRKAA2
cytosol 11 BCL2, CASP3, CAT, HMOX1, MAPK8, MTOR, NFE2L2, NOS2, PIK3CA, PPARG, PRKAA2
dendrite 3 BDNF, MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 1 NFE2L2
nucleoplasm 8 CASP3, HMOX1, MAPK8, MTOR, NFE2L2, NOS2, PPARG, PRKAA2
RNA polymerase II transcription regulator complex 2 NFE2L2, PPARG
Cell membrane 3 EGFR, TLR4, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell junction 1 EGFR
cell surface 3 EGFR, TLR4, TNF
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 2 NFE2L2, PRKAA2
Golgi membrane 3 EGFR, INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, PRKAA2, TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 2 NFE2L2, NOS2
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 6 EGFR, NFE2L2, NOS2, PIK3CA, TLR4, TNF
Membrane 8 BCL2, BDNF, CAT, EGFR, HMOX1, MTOR, PRKAA2, TLR4
apical plasma membrane 1 EGFR
axon 3 BDNF, MAPK8, PRKAA2
basolateral plasma membrane 1 EGFR
caveola 1 PTGS2
extracellular exosome 1 CAT
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, HMOX1, PTGS2
extracellular space 8 BDNF, CXCL8, EGFR, HMOX1, IL4, IL6, INS, TNF
perinuclear region of cytoplasm 7 BDNF, EGFR, HMOX1, NOS2, PIK3CA, PPARG, TLR4
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, CAT
protein-containing complex 4 BCL2, CAT, EGFR, PTGS2
intracellular membrane-bounded organelle 2 CAT, PPARG
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 EGFR, TLR4
Secreted 5 BDNF, CXCL8, IL4, IL6, INS
extracellular region 7 BDNF, CAT, CXCL8, IL4, IL6, INS, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
mitochondrial matrix 1 CAT
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 2 TLR4, TNF
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
focal adhesion 2 CAT, EGFR
Peroxisome 2 CAT, NOS2
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
nuclear speck 1 PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 EGFR, PPARG, TLR4
neuron projection 1 PTGS2
chromatin 2 NFE2L2, PPARG
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
cytoplasmic stress granule 1 PRKAA2
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BDNF, IL6, INS, PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 EGFR
protein-DNA complex 1 NFE2L2
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Huiyun Zhang, Yu Zhang, Yunfei Hu, Shunru Wei, Michael Adu-Frimpong, Congyong Sun, Gang Qi. Improving cellular uptake and synergetic anti-tumor effects of magnolol and Brucea javanica oil through self-microemulsion. Drug development and industrial pharmacy. 2024 May; 50(5):401-409. doi: 10.1080/03639045.2024.2329730. [PMID: 38466185]
  • Wei Li, Jie Lin, Jie Zhou, Siqi He, Anqi Wang, Yingfan Hu, Hanmei Li, Liang Zou, Ya Liu. Hyaluronic acid-functionalized DDAB/PLGA nanoparticles for improved oral delivery of magnolol in the treatment of ulcerative colitis. International journal of pharmaceutics. 2024 Mar; 653(?):123878. doi: 10.1016/j.ijpharm.2024.123878. [PMID: 38325622]
  • Katarzyna Szałabska-Rąpała, Maria Zych, Weronika Borymska, Piotr Londzin, Sławomir Dudek, Ilona Kaczmarczyk-Żebrowska. Beneficial effect of honokiol and magnolol on polyol pathway and oxidative stress parameters in the testes of diabetic rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Mar; 172(?):116265. doi: 10.1016/j.biopha.2024.116265. [PMID: 38364735]
  • Jing Yu, Xiaoyan Gao, Lijun Zhang, Hang Shi, Yingxuan Yan, Yongli Han, Chengyuan Wu, Ying Liu, Minglv Fang, Cheng Huang, Shengjie Fan. Magnolol extends lifespan and improves age-related neurodegeneration in Caenorhabditis elegans via increase of stress resistance. Scientific reports. 2024 02; 14(1):3158. doi: 10.1038/s41598-024-53374-9. [PMID: 38326350]
  • Jian Jiang, Xuefeng Hou, Kangjie Xu, Kangkang Ji, Zhongkai Ji, Juqun Xi, Xin Wang. Bacteria-targeted magnolol-loaded multifunctional nanocomplexes for antibacterial and anti-inflammatory treatment. Biomedical materials (Bristol, England). 2024 Jan; ?(?):. doi: 10.1088/1748-605x/ad2406. [PMID: 38290149]
  • Yue Yang, Zihe Li, Hang Zong, Shimeng Liu, Qiuhui Du, Hao Wu, Zhenzhu Li, Xiao Wang, Lihui Huang, Changlong Lai, Meide Zhang, Wen Wang, Xianqing Chen. Identification and Validation of Magnolol Biosynthesis Genes in Magnolia officinalis. Molecules (Basel, Switzerland). 2024 Jan; 29(3):. doi: 10.3390/molecules29030587. [PMID: 38338333]
  • Xi Fan, Zhuangzhuang Zhang, Wenxia Gao, Qingqing Pan, Kui Luo, Bin He, Yuji Pu. An Engineered Butyrate-Derived Polymer Nanoplatform as a Mucosa-Healing Enhancer Potentiates the Therapeutic Effect of Magnolol in Inflammatory Bowel Disease. ACS nano. 2024 Jan; 18(1):229-244. doi: 10.1021/acsnano.3c05732. [PMID: 38112525]
  • Yi Chu, Yazhen Zheng, Yingying Li, Sisi Gui, Jingwu Zhao, Yaxiang Zhao, Xiaodong Chen. Dietary supplementation of magnolol alleviates fatty liver hemorrhage syndrome in postpeak Xinhua laying hens via regulation of liver lipid metabolism. Poultry science. 2023 Dec; 103(3):103378. doi: 10.1016/j.psj.2023.103378. [PMID: 38228060]
  • Jintao Wang, Huan Liu, Zhuolin Sun, Xinyi Zou, Zixuan Zhang, Xiaofeng Wei, Lanying Pan, Antony Stalin, Wei Zhao, Yuan Chen. The Inhibitory Effect of Magnolol on the Human TWIK1 Channel Is Related to G229 and T225 Sites. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196815. [PMID: 37836658]
  • Lin Niu, Yu-Jie Lu, Xing-Wang Zu, Wen Yang, Fu-Kui Shen, Yan-Yan Xu, Min Jiang, Yang Xie, Su-Yun Li, Jie Gao, Gang Bai. Magnolol alleviates pulmonary fibrosis inchronic obstructive pulmonary disease by targeting transient receptor potential vanilloid 4-ankyrin repeat domain. Phytotherapy research : PTR. 2023 Sep; 37(9):4282-4297. doi: 10.1002/ptr.7907. [PMID: 37282760]
  • Jian-Yu Chen, Xiao-Yun Tian, Shan-Shan Wei, Wen Xu, Rong-Rong Pan, Lin-Lin Chen, Lang-Dong Chen, Li-Hong Nan, Yao-Lin, Shan-Deng, Qian-Qian Wang, Xue-Qin Ma, Ming-Qing Huang. Magnolol as STAT3 inhibitor for treating multiple sclerosis by restricting Th17 cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 117(?):154917. doi: 10.1016/j.phymed.2023.154917. [PMID: 37301184]
  • Riccardo Fontana, Laura Beatrice Mattioli, Giulia Biotti, Roberta Budriesi, Roberto Gotti, Matteo Micucci, Ivan Corazza, Peggy Marconi, Maria Frosini, Stefano Manfredini, Raissa Buzzi, Silvia Vertuani. Magnolia officinalis L. bark extract and respiratory diseases: From traditional Chinese medicine to western medicine via network target. Phytotherapy research : PTR. 2023 Jul; 37(7):2915-2938. doi: 10.1002/ptr.7786. [PMID: 36879409]
  • Ge Gao, Shaofang Niu, Tongtong Liu, Yan Zhang, Xueqing Zhao, Zhishang Shi, Shuai Chen, Mengmeng Wu, Guoqiang Li, Ting Ma. Fabrication of bacterial cellulose composites with antimicrobial properties by in situ modification utilizing the specific function-suspension containing water-insoluble magnolol. International journal of biological macromolecules. 2023 Apr; 239(?):124329. doi: 10.1016/j.ijbiomac.2023.124329. [PMID: 37019196]
  • Jia Cao, Shixia Zhang, Yanshuang Hao, Kai Fan, Lingling Wang, Xinghua Zhao, Xin He. Amorphous solid dispersion preparation via coprecipitation improves the dissolution, oral bioavailability, and intestinal health enhancement properties of magnolol. Poultry science. 2023 Apr; 102(6):102676. doi: 10.1016/j.psj.2023.102676. [PMID: 37104903]
  • Hu Qiao, Zhang Tengfei, Zhang Wenting, Lu Qin, Guo Yunqing, Cao Xiaoyi, Shao Huabin, Zhai Xinguo, Luo Qingping. Mechanistic insights of magnolol antimicrobial activity against Mycoplasma using untargeted metabolomic analyses. Frontiers in cellular and infection microbiology. 2023; 13(?):1325347. doi: 10.3389/fcimb.2023.1325347. [PMID: 38152121]
  • Juanzhen Yang, Yuxi Wei, Tong Zhao, Xiaoqian Li, Xuejian Zhao, Xingnan Ouyang, Lihua Zhou, Xiuqin Zhan, Minyi Qian, Jiaying Wang, Xu Shen. Magnolol effectively ameliorates diabetic peripheral neuropathy in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154434. doi: 10.1016/j.phymed.2022.154434. [PMID: 36122436]
  • Jidan Zhang, Hongmei Li, Liwei Hou, Jianhui Sun, Weihao Wang, Hua Li, Weipeng Yang, Peijing Rong, Tiegui Nan, Liping Kang, Bin Yang. Pharmacokinetics and metabolites of glycosides and lignans of the stem bark of Magnolia officinalis in functional dyspepsia and normal rats using liquid chromatography-tandem mass spectrometry. Journal of separation science. 2022 Oct; 45(19):3663-3678. doi: 10.1002/jssc.202100982. [PMID: 35908283]
  • Fang Chen, Hao Zhang, Na Zhao, Encun Du, Feng Jin, Qiwen Fan, Wanzheng Guo, Shaowen Huang, Jintao Wei. Effects of magnolol and honokiol blend on performance, egg quality, hepatic lipid metabolism, and intestinal morphology of hens at late laying cycle. Animal : an international journal of animal bioscience. 2022 Jun; 16(6):100532. doi: 10.1016/j.animal.2022.100532. [PMID: 35576638]
  • Lin Niu, Jie Wang, Fukui Shen, Jie Gao, Min Jiang, Gang Bai. Magnolol and honokiol target TRPC4 to regulate extracellular calcium influx and relax intestinal smooth muscle. Journal of ethnopharmacology. 2022 May; 290(?):115105. doi: 10.1016/j.jep.2022.115105. [PMID: 35157953]
  • Chia-Yu Tang, Chang-Chi Lai, Po-Hsun Huang, An-Han Yang, Shu-Chiung Chiang, Po-Chao Huang, Kuo-Wei Tseng, Cheng-Hsiung Huang. Magnolol reduces myocardial injury induced by renal ischemia and reperfusion. Journal of the Chinese Medical Association : JCMA. 2022 05; 85(5):584-596. doi: 10.1097/jcma.0000000000000727. [PMID: 35385419]
  • Jing Zhao, Pan Gao, Chengqiao Mu, Jingqi Ning, Wenbin Deng, Dongxu Ji, Haowei Sun, Xiangrong Zhang, Xinggang Yang. Preparation and Evaluation of Novel Supersaturated Solid Dispersion of Magnolol : Theme: Advancements in Amorphous Solid Dispersions to Improve Bioavailability. AAPS PharmSciTech. 2022 Mar; 23(4):97. doi: 10.1208/s12249-022-02251-7. [PMID: 35332440]
  • Xiaolin Dai, Long Xie, Kai Liu, Youdan Liang, Yi Cao, Jing Lu, Xian Wang, Xumin Zhang, Xiaofang Li. The neuropharmacological effects of magnolol and honokiol：a review of signal pathways and molecular mechanisms. Current molecular pharmacology. 2022 Feb; ?(?):. doi: 10.2174/1874467215666220223141101. [PMID: 35196977]
  • Sayeh Mottaghi, Hassan Abbaszadeh. Natural Lignans Honokiol and Magnolol as Potential Anticarcinogenic and Anticancer Agents. A Comprehensive Mechanistic Review. Nutrition and cancer. 2022; 74(3):761-778. doi: 10.1080/01635581.2021.1931364. [PMID: 34047218]
  • Ting Chen, Lan Shou, Xiaowen Guo, Mingyang Wei, Hui Zheng, Tao Tao. Magnolol attenuates the locomotor impairment, cognitive deficit, and neuroinflammation in Alzheimer's disease mice with brain insulin resistance via up-regulating miR-200c. Bioengineered. 2022 01; 13(1):531-543. doi: 10.1080/21655979.2021.2009975. [PMID: 34968163]
  • Min Young Kim, Jae Woo Han, Quang Le Dang, Jin-Cheol Kim, Hun Kim, Gyung Ja Choi. Characterization of Alternaria porri causing onion purple blotch and its antifungal compound magnolol identified from Caryodaphnopsis baviensis. PloS one. 2022; 17(1):e0262836. doi: 10.1371/journal.pone.0262836. [PMID: 35051224]
  • Feng-Ling Zhang, Xiao-Jie Yin, Yun-Liang Yan, Qiao-Feng Wu. Pharmacokinetics and Pharmacodynamics of Huanglian-Houpo Decoction Based on Berberine Hydrochloride and Magnolol Against H1N1 Influenza Virus. European journal of drug metabolism and pharmacokinetics. 2022 Jan; 47(1):57-67. doi: 10.1007/s13318-021-00724-x. [PMID: 34635990]
  • Chung-Ping Yu, Pei-Ying Li, Szu-Yu Chen, Shiuan-Pey Lin, Yu-Chi Hou. Magnolol and Honokiol Inhibited the Function and Expression of BCRP with Mechanism Exploration. Molecules (Basel, Switzerland). 2021 Dec; 26(23):. doi: 10.3390/molecules26237390. [PMID: 34885972]
  • Qiwen Fan, Fang Chen, Wei Zhang, Encun Du, Na Zhao, Shaowen Huang, Wanzheng Guo, Xianghua Yan, Mingxin Chen, Jintao Wei. Maternal magnolol supplementation alters placental morphology, promotes placental angiogenesis during mid-gestation and improves offspring growth in a pregnant mouse model. Reproductive biology. 2021 Dec; 21(4):100567. doi: 10.1016/j.repbio.2021.100567. [PMID: 34653815]
  • Encun Du, Qiwen Fan, Na Zhao, Wei Zhang, Jintao Wei, Fang Chen, Shaowen Huang, Wanzheng Guo. Supplemental magnolol improves the antioxidant capacity and intestinal health of broiler chickens. Animal science journal = Nihon chikusan Gakkaiho. 2021 Dec; 92(1):e13665. doi: 10.1111/asj.13665. [PMID: 34874084]
  • Georgiana Ioana Potra Cicalău, Petru Aurel Babes, Horia Calniceanu, Adelina Popa, Gabriela Ciavoi, Gilda Mihaela Iova, Mariana Ganea, Ioana Scrobotă. Anti-Inflammatory and Antioxidant Properties of Carvacrol and Magnolol, in Periodontal Disease and Diabetes Mellitus. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226899. [PMID: 34833990]
  • Ting Wang, Kaiju Xu, Liyun Zhao, Rongsheng Tong, Liang Xiong, Jianyou Shi. Recent research and development of NDM-1 inhibitors. European journal of medicinal chemistry. 2021 Nov; 223(?):113667. doi: 10.1016/j.ejmech.2021.113667. [PMID: 34225181]
  • Hu Li, Ying-Hui He, Yong-Mei Hu, Qing-Ru Chu, Yong-Jia Chen, Zhen-Rong Wu, Zhi-Jun Zhang, Ying-Qian Liu, Cheng-Jie Yang, Hong-Jie Liang, Yin-Fang Yan. Design, Synthesis, and Structure-Activity Relationship Studies of Magnolol Derivatives as Antifungal Agents. Journal of agricultural and food chemistry. 2021 Oct; 69(40):11781-11793. doi: 10.1021/acs.jafc.1c01838. [PMID: 34582205]
  • Feixu Mo, Xianfeng Hu, Yi Ding, Rongyu Li, Youhua Long, Xiaomao Wu, Ming Li. Naturally produced magnolol can significantly damage the plasma membrane of Rhizoctonia solani. Pesticide biochemistry and physiology. 2021 Oct; 178(?):104942. doi: 10.1016/j.pestbp.2021.104942. [PMID: 34446208]
  • Katarzyna Szałabska-Rąpała, Weronika Borymska, Ilona Kaczmarczyk-Sedlak. Effectiveness of Magnolol, a Lignan from Magnolia Bark, in Diabetes, Its Complications and Comorbidities-A Review. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms221810050. [PMID: 34576213]
  • Xiao Wang, Huan Gu, Huan Zhang, Jing Xian, Jingjing Li, Chaomei Fu, Chen Zhang, Jinming Zhang. Oral Core-Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy. ACS applied materials & interfaces. 2021 Jul; 13(29):33948-33961. doi: 10.1021/acsami.1c09804. [PMID: 34261306]
  • Ling Chen, Yu-Ting Wu, Xuan-Ye Gu, Ling-Peng Xie, Hui-Jie Fan, Zhang-Bin Tan, Wen-Tong Zhang, Hong-Mei Chen, Jun Li, Gui-Qiong Huang, Bin Liu, Ying-Chun Zhou, Xiao-Min Sun. Magnolol, a natural aldehyde dehydrogenase-2 agonist, inhibits the proliferation and collagen synthesis of cardiac fibroblasts. Bioorganic & medicinal chemistry letters. 2021 07; 43(?):128045. doi: 10.1016/j.bmcl.2021.128045. [PMID: 33865968]
  • Chenxia Han, Dan Du, Yongjian Wen, Jiawang Li, Rui Wang, Tao Jin, Jingyu Yang, Na Shi, Kun Jiang, Lihui Deng, Xianghui Fu, Rajarshi Mukherjee, John A Windsor, Jiwon Hong, Anthony R Phillips, Robert Sutton, Wei Huang, Tingting Liu, Qing Xia. Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways. Journal of ethnopharmacology. 2021 Jun; 274(?):114029. doi: 10.1016/j.jep.2021.114029. [PMID: 33731310]
  • Jing An, Chaoxing He, Caihui Guo, Zhanjun Dong. Application of hollow fiber centrifugal ultrafiltrate purification as the pretreatment technology for traditional Chinese medicine: its application for analysis of honokiol and magnolol in TCM preparations containing Cortex Magnoliae Officinalis. Annals of palliative medicine. 2021 Jun; 10(6):6359-6366. doi: 10.21037/apm-21-242. [PMID: 33752432]
  • Dongmei Jiang, Dizhe Wei, Hongtao Li, Liuqing Wang, Nan Jiang, Yunchao Li, Meng Wang. Natural occurrence of Alternaria mycotoxins in wheat and potential of reducing associated risks using magnolol. Journal of the science of food and agriculture. 2021 May; 101(7):3071-3077. doi: 10.1002/jsfa.10901. [PMID: 33124688]
  • Weimei Jin, Xiaoli Wang, Yuxiao Zeng, Yifen Lan, Xiaoqiu Wang. Magnolol suppressed cell migration and invasion and induced cell apoptosis via inhibition of the NF-κB signaling pathway by upregulating microRNA-129 in multiple myeloma. Neoplasma. 2021 Mar; 68(2):404-415. doi: 10.4149/neo_2020_200923n1010. [PMID: 33440989]
  • Yuhong Cao, Yan Cao, Yiwei Shi, Ying Cai, Langdong Chen, Dongyao Wang, Yue Liu, Xiaofei Chen, Zhenyu Zhu, Zhanying Hong, Yifeng Chai. Surface plasmon resonance biosensor combined with lentiviral particle stabilization strategy for rapid and specific screening of P-Glycoprotein ligands. Analytical and bioanalytical chemistry. 2021 Mar; 413(7):2021-2031. doi: 10.1007/s00216-021-03170-5. [PMID: 33528601]
  • Yu Chen, Xiuyun He, Dagang Feng, Shijie Li. Compare the Effects of Magnolol on Gastric Cancer Cells Through c-Jun N-Terminal Kinase Signaling Pathway and Gold Magnetic. Journal of nanoscience and nanotechnology. 2021 Feb; 21(2):943-948. doi: 10.1166/jnn.2021.18688. [PMID: 33183428]
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