Milk Thistle Extract (BioDeep_00000396894)

Main id: BioDeep_00000230327

 

PANOMIX_OTCML-2023


代谢物信息卡片


Milk Thistle Extract

化学式: C25H22O10 (482.1212912)
中文名称: 水飞蓟提取物, 水飞蓟素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=CC(=C1)C2C(OC3=C(O2)C=C(C=C3)C4C(C(=O)C5=C(C=C(C=C5O4)O)O)O)CO)O
InChI: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

描述信息

A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy
D020011 - Protective Agents > D000975 - Antioxidants
(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

同义名列表

10 个代谢物同义名

Milk Thistle Extract; SILYMARIN; Silymarin 10.03 min; Silymarin 10.15 min; Silibinin (mixture of Silybin A and Silybin B); (±)-Silybin; Silibinin; Silybin; Silibinin A; Silybin A



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fatma M El-Demerdash, Manal M Ahmed, Raghda A El-Sayed, Tarek M Mohemed, Marian N Gerges. Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum-induced oxidative stress, hyperlipidemia, and genotoxicity. Environmental toxicology. 2024 Jun; 39(6):3746-3759. doi: 10.1002/tox.24223. [PMID: 38546352]
  • J Anupama Sekar, Shiny Velayudhan, M Senthilkumar, P R Anil Kumar. Silymarin enriched gelatin methacrylamide bioink imparts hepatoprotectivity to 3D bioprinted liver construct against carbon tetrachloride induced toxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 May; 198(?):114272. doi: 10.1016/j.ejpb.2024.114272. [PMID: 38537909]
  • Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081169. [PMID: 38674860]
  • Zoe D. Draelos, Martina Kerscher, Stephen Lynch, Stacy White, Hina Choudhary. A Silymarin Antioxidant Serum Improves Facial Acne Alone and as Part of a Treatment Regimen. Journal of drugs in dermatology : JDD. 2024 04; 23(4):233-238. doi: 10.36849/jdd.8120. [PMID: 38564394]
  • Lucia-Maria Ciovicescu, Simona Valeria Clichici, Ramona-Ariana Simedrea, Felix Ciovicescu, Simona Corina Lupan, Lavinia Ioana Sabău, Alina Mihaela Toader, Teodora Mocan. Innovative prophylactic and therapeutic approaches in liver cirrhosis. Physiology international. 2024 Mar; 111(1):1-18. doi: 10.1556/2060.2024.00339. [PMID: 38421387]
  • Hebatallah Husseini Atteia. A combination of silymarin and garlic extract enhances thyroid hormone activation and body metabolism in orally intoxicated male rats with atrazine: Impact on hepatic iodothyronine deiodinase type 1. Pesticide biochemistry and physiology. 2024 Feb; 199(?):105801. doi: 10.1016/j.pestbp.2024.105801. [PMID: 38458692]
  • Rajeev K Singla, Digvijay Singh, Ravinder Verma, Deepak Kaushik, Javier Echeverría, Vandana Garg, Pankaj Gupta, Mohammad Akhlaquer Rahman, Ajay Sharma, Vineet Mittal, Bairong Shen. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155286. doi: 10.1016/j.phymed.2023.155286. [PMID: 38241906]
  • Xin Zhang, Yuhan Jiang, Na Guo, Yifan Ding, Jingting Feng, Chenyang Miao, Yanni Lv. Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115816. doi: 10.1016/j.jpba.2023.115816. [PMID: 37976988]
  • Mohammad Reza Karimzadeh, Afsane Masoudi Chelegahi, Shahrzad Shahbazi, Somayeh Reiisi. Co-treatment of silymarin and cisplatin inhibited cell proliferation, induced apoptosis in ovarian cancer. Molecular biology reports. 2024 Jan; 51(1):118. doi: 10.1007/s11033-023-09026-8. [PMID: 38227082]
  • Jyoti Rani, Sanju Bala Dhull, Pawan Kumar Rose, Mohd Kashif Kidwai. Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155142. doi: 10.1016/j.phymed.2023.155142. [PMID: 37913641]
  • Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. The Journal of steroid biochemistry and molecular biology. 2023 Dec; 238(?):106450. doi: 10.1016/j.jsbmb.2023.106450. [PMID: 38143010]
  • Helena Pluháčková, Barbora Kudláčková, Lenka Svojanovská, Michal Roth, Marta Bradáčová, Marie Bjelková. Effect of Field Trial on Silymarin Complex Composition and Antioxidant Assessment of Milk Thistle (Silybum marianum L. Gaertner). Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Dec; 78(4):691-697. doi: 10.1007/s11130-023-01101-6. [PMID: 37668769]
  • Zhenzhen Chen, Wenhao Gao, Xianquan Feng, Guizhi Zhou, Minxin Zhang, Lingjun Zeng, Xiaomu Hu, Zhihong Liu, Hongtao Song. A comparative study on the preparation and evaluation of solubilizing systems for silymarin. Drug delivery and translational research. 2023 Nov; ?(?):. doi: 10.1007/s13346-023-01476-8. [PMID: 37964172]
  • Rasool Haddadi, Shahla Eyvari-Brooshghalan, Sajjad Makhdoomi, Ahmad Fadaiie, Alireza Komaki, Afsoon Daneshvar. Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02776-z. [PMID: 37847410]
  • Salah A Sheweita, Ahmed Abd El Rafea, Sabah G Elbana. The deleterious effects of cadmium on oxidative stress markers, drug-metabolizing, and antioxidant enzyme activities: Role of Silymarin and Garlic as Antioxidants. Environmental science and pollution research international. 2023 Oct; ?(?):. doi: 10.1007/s11356-023-30197-1. [PMID: 37831250]
  • Hanaa S S Gazwi, Osama I A Soltan, Sanaa M Abdel-Hameed. Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity. Environmental science and pollution research international. 2023 Oct; ?(?):. doi: 10.1007/s11356-023-30172-w. [PMID: 37815681]
  • Pei-Ling Yen, Ting-An Lin, Wei Lin Chuah, Chih-Yi Chang, Yen-Hsueh Tseng, Chia-Yin Huang, Jeng-Chuann Yang, Fu-Lan Hsu, Vivian Hsiu-Chuan Liao. Methanol Extracts from Cirsium japonicum DC. var. australe Kitam. and Their Active Components Reduce Intracellular Oxidative Stress in Caenorhabditis elegans. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196923. [PMID: 37836767]
  • Ahmed H Sherif, Adel E Toulan, Naglaa El-Kalamwi, Enas A H Farag, Abeer E Mahmoud. Silymarin enhances the response to oxytetracycline treatment in Oreochromis niloticus experimentally infected with Aeromonas hydrophila. Scientific reports. 2023 Sep; 13(1):16235. doi: 10.1038/s41598-023-43270-z. [PMID: 37758826]
  • Sajida Sumaiya, Aisha Siddiqui, Shahid Shah Chaudhary, Mohd Aslam, Sayeed Ahmad, Mairaj Ahmed Ansari. Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. To evaluate its hepatoprotective activity. Journal of ethnopharmacology. 2023 Sep; ?(?):117185. doi: 10.1016/j.jep.2023.117185. [PMID: 37714225]
  • Fatemeh Gheybi, Fatemeh Rajabian, Zahra Tayarani-Najaran, Amir Reza Adibi, Seyedeh Hoda Alavizadeh, Prashant Kesharwani, Amirhossein Sahebkar. Liposomal silymarin anti-oxidative and anti-apoptotic features in lung cells: An implication in cadmium toxicity. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2023 Aug; 80(?):127291. doi: 10.1016/j.jtemb.2023.127291. [PMID: 37672872]
  • Hossein Abbasinia, Masoumeh Heshmati, Mohammad Yousefi, Nabaa Najjar, Hanieh Sadeghi. Silymarin-Loaded Tin(IV) Nanoparticles Exhibit Enhanced Bioavailability and Antiproliferative Effects on Colorectal Cancer Cells. ACS applied bio materials. 2023 Aug; ?(?):. doi: 10.1021/acsabm.3c00434. [PMID: 37608575]
  • Iman H Hasan, Amirah Badr, Haneen Almalki, Alanoud Alhindi, Hesham S Mostafa. Podocin, mTOR, and CHOP dysregulation contributes to nephrotoxicity induced of lipopolysaccharide/diclofenac combination in rats: Curcumin and silymarin could afford protective effect. Life sciences. 2023 Aug; 330(?):121996. doi: 10.1016/j.lfs.2023.121996. [PMID: 37536613]
  • Hamed Baharara, Sara Rahsepar, Seyyed Ahmad Emami, Sepideh Elyasi, Amir Hooshang Mohammadpour, Vahid Ghavami, Rajkumar Rajendram, Amirhossein Sahebkar, Omid Arasteh. The efficacy of medicinal plant preparations in the alleviation of radiodermatitis in patients with breast cancer: A systematic review of clinical trials. Phytotherapy research : PTR. 2023 Aug; 37(8):3275-3295. doi: 10.1002/ptr.7894. [PMID: 37211432]
  • A Jabbari, B Alani, A Arjmand, T Mazoochi, N Kheiripour, A Ardjmand. Silymarin pretreatment protects against ethanol-induced memory impairment: Biochemical and histopathological evidence. Journal of chemical neuroanatomy. 2023 Jul; 132(?):102310. doi: 10.1016/j.jchemneu.2023.102310. [PMID: 37429530]
  • Paolo Bellavite, Serafino Fazio, Flora Affuso. A Descriptive Review of the Action Mechanisms of Berberine, Quercetin and Silymarin on Insulin Resistance/Hyperinsulinemia and Cardiovascular Prevention. Molecules (Basel, Switzerland). 2023 Jun; 28(11):. doi: 10.3390/molecules28114491. [PMID: 37298967]
  • Leila Parsa, Rouhollah Motafakkerazad, Sarvin Taleb Soheyli, Amin Haratian, Morteza Kosari-Nasab, Majid Mahdavi. Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells. Toxicon : official journal of the International Society on Toxinology. 2023 Jun; 228(?):107127. doi: 10.1016/j.toxicon.2023.107127. [PMID: 37085055]
  • Elnaz Golestaneh, Abolfazl Aslani, Mahmoud Aghaei, Mohammad Hashemnia, Mohammad Hosein Aarabi. Preparation and characterisation of a new form of silymarin as a potential antidiabetic agent in the adult male rat. Archives of physiology and biochemistry. 2023 Jun; 129(3):799-809. doi: 10.1080/13813455.2021.1874018. [PMID: 33529090]
  • Peichen Wang, Ning Yang, Ying Luo, Gan Wang, Shuaizhen Zhou, Shuai Huang, Li Chen, Yiping Zhao. Silymarin modified polysulfone hollow fiber membranes with antioxidant, anti-M1 macrophage polarization and hemocompatibility for blood purification. Journal of biomedical materials research. Part B, Applied biomaterials. 2023 May; ?(?):. doi: 10.1002/jbm.b.35285. [PMID: 37255001]
  • Doriana Eurosia Angela Tedesco, Alessandro Guerrini. Use of Milk Thistle in Farm and Companion Animals: A Review. Planta medica. 2023 May; 89(6):584-607. doi: 10.1055/a-1969-2440. [PMID: 36302565]
  • Mehran Ebrahimi Shah-Abadi, Armin Ariaei, Fatemeh Moradi, Auob Rustamzadeh, Rastegar Rahmani Tanha, Nader Sadigh, Mohsen Marzban, Mahdi Heydari, Vahid Tavakolian Ferdousie. In Silico Interactions of Natural and Synthetic Compounds with Key Proteins Involved in Alzheimer's Disease: Prospects for Designing New Therapeutics Compound. Neurotoxicity research. 2023 Apr; ?(?):. doi: 10.1007/s12640-023-00648-1. [PMID: 37086338]
  • D Shah, N Mahurkar, D Gadhave, R Nikhate, K Kakad. Hepatoprotective activity of Balsamodendron mukul extract against Paracetamol-induced liver toxicity in rats: In vivo pharmacological and toxicological evaluation. Annales pharmaceutiques francaises. 2023 Apr; ?(?):. doi: 10.1016/j.pharma.2023.04.003. [PMID: 37060939]
  • Yingwen Bai, Lulu Wang, TingYang, Lingyun Wang, Weihong Ge. Silymarin ameliorates peritoneal fibrosis by inhibiting the TGF-β/Smad signaling pathway. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Apr; ?(?):. doi: 10.1007/s00210-023-02450-4. [PMID: 37052642]
  • Meghanath B Shete, Ashwini S Deshpande, Pravin Shende. Enhancement of in-vitro anti-oral cancer activities of silymarin using dispersion of nanostructured lipid carrier in mucoadhesive in-situ gel. International journal of pharmaceutics. 2023 Apr; 636(?):122860. doi: 10.1016/j.ijpharm.2023.122860. [PMID: 36933584]
  • D Jayabal, S Jayanthi, R Thirumalaisamy, R Karthika, Muhammad Nasir Iqbal. Comparative anti-Diabetic potential of phytocompounds from Dr. Duke's phytochemical and ethnobotanical database and standard antidiabetic drugs against diabetes hyperglycemic target proteins: an in silico validation. Journal of biomolecular structure & dynamics. 2023 Apr; ?(?):1-13. doi: 10.1080/07391102.2023.2187231. [PMID: 37011006]
  • Kassahun Dires Ayenew, Yared Wasihun. Hepatoprotective effect of methanol extract of Agave americana leaves on paracetamol induced hepatotoxicity in Wistar albino rats. BMC complementary medicine and therapies. 2023 Apr; 23(1):99. doi: 10.1186/s12906-023-03931-y. [PMID: 37005601]
  • Arwa A Elsheikh, Sulaiman Mohammed Alnasser, Amany Mohamed Shalaby, Mohamed Ali Alabiad, Noha Ali Abd-Almotaleb, Mohammed Alorini, Fatima A Jaber, Eman El-Sayed Khayal. Polystyrene microplastic particles induced hepatotoxic injury via pyroptosis, oxidative stress, and fibrotic changes in adult male albino rats; the therapeutic role of silymarin. Toxicology mechanisms and methods. 2023 Mar; ?(?):1-17. doi: 10.1080/15376516.2023.2191270. [PMID: 36970996]
  • Subhasish Sahoo, Diptirani Rath, Durga Madhab Kar, Sovan Pattanaik. Hepatoprotective potency of Litsea glutinosa (L.) C.B. Rob. leaf methanol extract on H2O2-induced toxicity in HepG2 cells. Journal of ethnopharmacology. 2023 Mar; 304(?):116076. doi: 10.1016/j.jep.2022.116076. [PMID: 36567040]
  • Longlong Liu, Hua Zhang. Milk Thistle Oil Extracted by Enzyme-Mediated Assisted Solvent Extraction Compared with n-Hexane and Cold-Pressed Extraction. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062591. [PMID: 36985564]
  • Wen-Long Sun, Sha Hua, Xin-Yu Li, Liang Shen, Hao Wu, Hong-Fang Ji. Microbially produced vitamin B12 contributes to the lipid-lowering effect of silymarin. Nature communications. 2023 01; 14(1):477. doi: 10.1038/s41467-023-36079-x. [PMID: 36717576]
  • Sreevarsha Gali, Swati Sharma, Amit Kundu, Eunah Lee, Joo Hee Han, Joo Kyung Shin, Ji Soo Choi, So Young Kyung, Jae-Sung Kim, Hyung Sik Kim. Protective effect of dendropanoxide against cadmium-induced hepatotoxicity via anti-inflammatory activities in Sprague-Dawley rats. Toxicology mechanisms and methods. 2023 Jan; ?(?):1-15. doi: 10.1080/15376516.2023.2171824. [PMID: 36718047]
  • Hosny Abd El Fadil, Amany Behairy, Lamiaa L M Ebraheim, Yasmina M Abd-Elhakim, Heba Hussein Fathy. The palliative effect of mulberry leaf and olive leaf ethanolic extracts on hepatic CYP2E1 and caspase-3 immunoexpression and oxidative damage induced by paracetamol in male rats. Environmental science and pollution research international. 2023 Jan; ?(?):. doi: 10.1007/s11356-023-25152-z. [PMID: 36637651]
  • Vijay Kumar Shankar, Anitha Police, Srinivas Ajjarapu, S Narasimha Murthy. Development of silymarin topical formulation: In vitro and ex vivo dermal kinetics of silymarin. International journal of pharmaceutics. 2023 Jan; 630(?):122431. doi: 10.1016/j.ijpharm.2022.122431. [PMID: 36436747]
  • Ali Hanafi, Kazem D Safa, Shamsali Rezazadeh. Neural Network-based Optimization of Silybum Marianum Extract-loaded Chitosan Particles: Modeling, Preparation and Antioxidant Evaluation. Current computer-aided drug design. 2023; 19(1):2-12. doi: 10.2174/1573409918666221010101036. [PMID: 36221887]
  • Garima Singh, Namrata Mittra, Chetna Singh. Tempol and silymarin rescue from zinc-induced degeneration of dopaminergic neurons through modulation of oxidative stress and inflammation. Molecular and cellular biochemistry. 2022 Dec; ?(?):. doi: 10.1007/s11010-022-04620-z. [PMID: 36562918]
  • Eman S Alamri, Haddad A El Rabey, Othman R Alzahrani, Fahad M Almutairi, Eman S Attia, Hala M Bayomy, Renad A Albalwi, Samar M Rezk. Enhancement of the Protective Activity of Vanillic Acid against Tetrachloro-Carbon (CCl4) Hepatotoxicity in Male Rats by the Synthesis of Silver Nanoparticles (AgNPs). Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238308. [PMID: 36500401]
  • Chandan Sarkar, Milon Mondal, Khattab Al-Khafaji, Dina M El-Kersh, Sarmin Jamaddar, Pranta Ray, Uttam Kumar Roy, Mirola Afroze, Md Moniruzzaman, Mala Khan, Umma Hafsa Asha, Abul Bashar Ripon Khalipha, Edna Mori, Bruna Caroline Gonçalves Vasconcelos de Lacerda, Isaac Moura Araújo, Henrique Douglas Melo Coutinho, Manik Chandra Shill, Muhammad Torequl Islam. GC-MS analysis, and evaluation of protective effect of Piper chaba stem bark against paracetamol-induced liver damage in Sprague-Dawley rats: Possible defensive mechanism by targeting CYP2E1 enzyme through in silico study. Life sciences. 2022 Nov; 309(?):121044. doi: 10.1016/j.lfs.2022.121044. [PMID: 36208657]
  • Rwaida A Al-Haidari, Firdous Sayeed Mohammed, Aisha Alhaddad, Waad A Samman, Abdelaziz Aa El-Sayed, Ahmed Ah Abdellatif, Mahmoud Ah Mostafa. Hepatoprotective activity of Ipomoea staphylina againsts d-glan/lps-induced acute hepatic failure in experimental rats. Pakistan journal of pharmaceutical sciences. 2022 Nov; 35(6):1663-1668. doi: . [PMID: 36789826]
  • Eman A R Abdelghffar, Heba A S El-Nashar, Shaimaa Fayez, Wael A Obaid, Omayma A Eldahshan. Ameliorative effect of oregano (Origanum vulgare) versus silymarin in experimentally induced hepatic encephalopathy. Scientific reports. 2022 10; 12(1):17854. doi: 10.1038/s41598-022-20412-3. [PMID: 36284120]
  • Kamal Y Thajudeen, Yahya I Asiri, Shahana Salam, Shabeer Ali Thorakkattil, Mohamed Rahamathulla, Ilyas Uoorakkottil. A Box-Behnken Extraction Design and Hepatoprotective Effect of Isolated Eupalitin-3-O-β-D-Galactopyranoside from Boerhavia diffusa Linn. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196444. [PMID: 36234981]
  • Thakur Rohit Singh, Devaraj Ezhilarasan. Lagerstroemia speciosa (L.) Pers., ethanolic leaves extract attenuates dapsone-induced liver inflammation in rats. Drug and chemical toxicology. 2022 Sep; 45(5):2361-2370. doi: 10.1080/01480545.2021.1945079. [PMID: 34225555]
  • Charles O Nwonuma, Victoria C Nwatu, Gomaa Mostafa-Hedeab, Oluyomi S Adeyemi, Omokolade O Alejolowo, Oluwafemi Adeleke Ojo, Sylvanus A Adah, Oluwakemi J Awakan, Charles E Okolie, Nnaemeka Tobechukwu Asogwa, Inemesit A Udofia, Godshelp O Egharevba, Nada H Aljarba, Saad Alkahtani, Gaber El-Saber Batiha. Experimental validation and molecular docking to explore the active components of cannabis in testicular function and sperm quality modulations in rats. BMC complementary medicine and therapies. 2022 Aug; 22(1):227. doi: 10.1186/s12906-022-03704-z. [PMID: 36028848]
  • Karan Wadhwa, Rakesh Pahwa, Manish Kumar, Shobhit Kumar, Prabodh Chander Sharma, Govind Singh, Ravinder Verma, Vineet Mittal, Inderbir Singh, Deepak Kaushik, Philippe Jeandet. Mechanistic Insights into the Pharmacological Significance of Silymarin. Molecules (Basel, Switzerland). 2022 Aug; 27(16):. doi: 10.3390/molecules27165327. [PMID: 36014565]
  • Norelhouda Abderrezag, Zully J Suárez Montenegro, Ouahida Louaer, Abdeslam-Hassen Meniai, Alejandro Cifuentes, Elena Ibáñez, Jose A Mendiola. One-step sustainable extraction of Silymarin compounds of wild Algerian milk thistle (Silybum marianum) seeds using Gas Expanded Liquids. Journal of chromatography. A. 2022 Jul; 1675(?):463147. doi: 10.1016/j.chroma.2022.463147. [PMID: 35640448]
  • Sania Ishtiaq, Shamim Akhtar Qureshi, Syed Abdul Aziz. Protective role of Avena fatua against drug-induced liver toxicity. Pakistan journal of pharmaceutical sciences. 2022 Jul; 35(4):1023-1030. doi: . [PMID: 36008898]
  • Abdelaaty A Shahat, Riaz Ullah, Ali S Alqahtani, Heba M Hassanein, Husseiny A Husseiny, Nahla M Mohammed, Rashed N Herqash. Nephroprotective effect of persimmon leaves (Diospyros kaki L.f.) against CCl4-induced renal toxicity in Swiss Albino rats. Drug and chemical toxicology. 2022 Jul; 45(4):1578-1586. doi: 10.1080/01480545.2020.1849269. [PMID: 33522322]
  • Maggie E Amer, Maher A Amer, Azza I Othman, Doaa A Elsayed, Mohamed Amr El-Missiry, Omar A Ammar. Silymarin inhibits the progression of Ehrlich solid tumor via targeting molecular pathways of cell death, proliferation, angiogenesis, and metastasis in female mice. Molecular biology reports. 2022 Jun; 49(6):4659-4671. doi: 10.1007/s11033-022-07315-2. [PMID: 35305227]
  • Hana Dockalova, Daria Baholet, Andrej Batik, Ladislav Zeman, Pavel Horky. Effect of Milk Thistle (Silybum marianum) Seed Cakes by Horses Subjected to Physical Exertion. Journal of equine veterinary science. 2022 06; 113(?):103937. doi: 10.1016/j.jevs.2022.103937. [PMID: 35318098]
  • Zhiheng Zhang, Xiaojing Li, Shangyuan Sang, David Julian McClements, Long Chen, Jie Long, Aiquan Jiao, Jinpeng Wang, Zhengyu Jin, Chao Qiu. A review of nanostructured delivery systems for the encapsulation, protection, and delivery of silymarin: An emerging nutraceutical. Food research international (Ottawa, Ont.). 2022 06; 156(?):111314. doi: 10.1016/j.foodres.2022.111314. [PMID: 35651070]
  • Nabila Zein, Fathy Yassin, Shaza Makled, Saqer S Alotaibi, Sarah M Albogami, Gomaa Mostafa-Hedeab, Gaber El-Saber Batiha, Yaser Hosny Ali Elewa. Oral supplementation of policosanol alleviates carbon tetrachloride-induced liver fibrosis in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113020. doi: 10.1016/j.biopha.2022.113020. [PMID: 35658249]
  • Arif Ali, Haroon Khan, Danial Kahrizi, Samreen Pervez, Ghallab Alotaibi, Luca Rastrelli. Nephroprotective effects of Helianthus annuus seeds extract in gentamicin induced nephrotoxic male mice. Cellular and molecular biology (Noisy-le-Grand, France). 2022 May; 68(1):1-7. doi: 10.14715/cmb/2022.68.1.1. [PMID: 35809335]
  • Abdullah Saad Abdullah, Ibrahim El Tantawy El Sayed, Abdel Moneim A El-Torgoman, Abul Kalam, S Wageh, Maher A Kamel. Green Synthesis of Silymarin-Chitosan Nanoparticles as a New Nano Formulation with Enhanced Anti-Fibrotic Effects against Liver Fibrosis. International journal of molecular sciences. 2022 May; 23(10):. doi: 10.3390/ijms23105420. [PMID: 35628233]
  • Olajumoke Olufunlayo Nwaechefu, Tomilola Debby Olaolu, Ifeoluwa Racheal Akinwunmi, Omotunde Oluwaseyi Ojezele, Olufunso Olabode Olorunsogo. Cajanus cajan ameliorated CCl4-induced oxidative stress in Wistar rats via the combined mechanisms of anti-inflammation and mitochondrial-membrane transition pore inhibition. Journal of ethnopharmacology. 2022 May; 289(?):114920. doi: 10.1016/j.jep.2021.114920. [PMID: 35032580]
  • Katia Azarfar, Parichehreh Yaghmaei, Mahsa M Amoli, Nasim Hayati-Roodbari, Azadeh Ebrahim-Habibi. Local Insulin-Derived Amyloidosis Model Confronted with Silymarin: Histological Insights and Gene Expression of MMP, TNF-α, and IL-6. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23094952. [PMID: 35563343]
  • Rastislav Boško, Marek Pernica, Sylvie Běláková, Marie Bjelková, Helena Pluháčková. Determination of T-2 and HT-2 Toxins in Seed of Milk Thistle [Silybum marianum (L.) Gaertn.] Using Immunoaffinity Column by UPLC-MS/MS. Toxins. 2022 04; 14(4):. doi: 10.3390/toxins14040258. [PMID: 35448867]
  • Weronika Borymska, Maria Zych, Sławomir Dudek, Ilona Kaczmarczyk-Sedlak. Silymarin from Milk Thistle Fruits Counteracts Selected Pathological Changes in the Lenses of Type 1 Diabetic Rats. Nutrients. 2022 Mar; 14(7):. doi: 10.3390/nu14071450. [PMID: 35406062]
  • Lal Chand Pal, Shivankar Agrawal, Arti Gautam, Jayhind Kumar Chauhan, Chandana Venkateswara Rao. Hepatoprotective and Antioxidant Potential of Phenolics-Enriched Fraction of Anogeissus acuminata Leaf against Alcohol-Induced Hepatotoxicity in Rats. Medical sciences (Basel, Switzerland). 2022 03; 10(1):. doi: 10.3390/medsci10010017. [PMID: 35323216]
  • E S Said, A H Mohammed, H M Ali, A Y Babiker, R Alnughaymishi, N Z Althaqeel, A S Ahmed. Evaluation of hepatoprotective effect of Nebivolol and sodium copper Chlorophyllin on CCL4-induced hepatotoxicity in mice. European review for medical and pharmacological sciences. 2022 Mar; 26(5):1717-1728. doi: 10.26355/eurrev_202203_28241. [PMID: 35302221]
  • Prarambh S R Dwivedi, Vishal S Patil, Pukar Khanal, Vishwambhar V Bhandare, Shailendra Gurav, Darasaguppe R Harish, B M Patil, Subarna Roy. System biology-based investigation of Silymarin to trace hepatoprotective effect. Computers in biology and medicine. 2022 03; 142(?):105223. doi: 10.1016/j.compbiomed.2022.105223. [PMID: 35033877]
  • Burak Dumludag, Mehmet Kursat Derici, Osman Sutcuoglu, Betul Ogut, Ozge Tugce Pasaoglu, Ipek Isık Gonul, Ulver Derici. Role of silymarin (Silybum marianum) in the prevention of colistin-induced acute nephrotoxicity in rats. Drug and chemical toxicology. 2022 Mar; 45(2):568-575. doi: 10.1080/01480545.2020.1733003. [PMID: 32174194]
  • Aliaa Abdelmoniem Bedeir Eita. Milk thistle (Silybum marianum (L.)Gaertn.): An overview about its pharmacology and medicinal uses with an emphasis on oral diseases. Journal of oral biosciences. 2022 Mar; 64(1):71-76. doi: 10.1016/j.job.2021.12.005. [PMID: 34968721]
  • Nemany A N Hanafy, Maged A El-Kemary. Silymarin/curcumin loaded albumin nanoparticles coated by chitosan as muco-inhalable delivery system observing anti-inflammatory and anti COVID-19 characterizations in oleic acid triggered lung injury and in vitro COVID-19 experiment. International journal of biological macromolecules. 2022 Feb; 198(?):101-110. doi: 10.1016/j.ijbiomac.2021.12.073. [PMID: 34968533]
  • Arpamas Chariyakornkul, Waristha Juengwiroj, Jetsada Ruangsuriya, Rawiwan Wongpoomchai. Antioxidant Extract from Cleistocalyx nervosum var. paniala Pulp Ameliorates Acetaminophen-Induced Acute Hepatotoxicity in Rats. Molecules (Basel, Switzerland). 2022 Jan; 27(2):. doi: 10.3390/molecules27020553. [PMID: 35056867]
  • Wei Wang, Qiyu Liu, Xianchun Liang, Qi Kang, Zinian Wang. Protective role of naringin loaded solid nanoparticles against aflatoxin B1 induced hepatocellular carcinoma. Chemico-biological interactions. 2022 Jan; 351(?):109711. doi: 10.1016/j.cbi.2021.109711. [PMID: 34717916]
  • Pengsheng Wei, Xue Li, Shuai Wang, Yanxin Dong, Haoran Yin, Zikun Gu, Xiaoting Na, Xi Wei, Jiayu Yuan, Jiahui Cao, Haotian Gao, Yebo Su, Yong Xu Chen, Ge Jin. Silibinin Ameliorates Formaldehyde-Induced Cognitive Impairment by Inhibiting Oxidative Stress. Oxidative medicine and cellular longevity. 2022; 2022(?):5981353. doi: 10.1155/2022/5981353. [PMID: 35757504]
  • Duygu Doğan, İsmet Meydan, Ahmet Ufuk Kömüroğlu. Protective Effect of Silymarin and Gallic Acid against Cisplatin-Induced Nephrotoxicity and Hepatotoxicity. International journal of clinical practice. 2022; 2022(?):6541026. doi: 10.1155/2022/6541026. [PMID: 35685593]
  • Sophia Mayr, Simon Strasser, Christian G Kirchler, Florian Meischl, Stefan Stuppner, Krzysztof B Beć, Justyna Grabska, Sonja Sturm, Hermann Stuppner, Michael A Popp, Günther K Bonn, Christian W Huck. Quantification of Silymarin in Silybi mariani fructus: Challenging the Analytical Performance of Benchtop vs. Handheld NIR Spectrometers on Whole Seeds. Planta medica. 2022 Jan; 88(1):20-32. doi: 10.1055/a-1326-2497. [PMID: 33434938]
  • Roshanak Khazaei, Alireza Seidavi, Mehrdad Bouyeh. A review on the mechanisms of the effect of silymarin in milk thistle (Silybum marianum) on some laboratory animals. Veterinary medicine and science. 2022 01; 8(1):289-301. doi: 10.1002/vms3.641. [PMID: 34599793]
  • Tomas Koltai, Larry Fliegel. Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions. Journal of evidence-based integrative medicine. 2022 Jan; 27(?):2515690X211068826. doi: 10.1177/2515690x211068826. [PMID: 35018864]
  • Hamid Rahmani, Hossein Khalili. Prevention of Vancomycin-Induced Nephrotoxicity; An Updated Review of Clinical and Preclinical Studies. Infectious disorders drug targets. 2022; 22(2):e310321192584. doi: 10.2174/1871526521666210331164552. [PMID: 33797371]
  • C Jia, Z Zhang, J Wang, Z Nie. Silymarin protects the rats against paraquat-induced acute kidney injury via Nrf2. Human & experimental toxicology. 2022 Jan; 41(?):9603271221074334. doi: 10.1177/09603271221074334. [PMID: 35128959]
  • Devaraj Ezhilarasan, Thangavelu Lakshmi. A Molecular Insight into the Role of Antioxidants in Nonalcoholic Fatty Liver Diseases. Oxidative medicine and cellular longevity. 2022; 2022(?):9233650. doi: 10.1155/2022/9233650. [PMID: 35602098]
  • Seerat Mehdi, Fiaz-Ud-Din Ahmad, Arslan Hussain Lodhi, Umair Khurshid, Ahmed Awais Khalid, Sheikh Safeena Sidiq, Liaqat Hussain, Mirza Shaharyar Baig. Protective Effects of p-CA Against Acute Liver Damage Induced by LPS/D-GalN in Wistar Albino Rats. Drug design, development and therapy. 2022; 16(?):3327-3342. doi: 10.2147/dddt.s380324. [PMID: 36199629]
  • Nour Y S Yassin, Sameh F AbouZid, Asmaa M El-Kalaawy, Tarek M Ali, Mazen M Almehmadi, Osama M Ahmed. Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112409. doi: 10.1016/j.biopha.2021.112409. [PMID: 34781148]
  • Kailin Yang, Junpeng Chen, Tianqing Zhang, Xiao Yuan, Anqi Ge, Shanshan Wang, Hao Xu, Liuting Zeng, Jinwen Ge. Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis. Frontiers in immunology. 2022; 13(?):949746. doi: 10.3389/fimmu.2022.949746. [PMID: 36159792]
  • Yong-Joo Park, Dong-Min Kim, Hye-Been Choi, Mi-Ho Jeong, Seung-Hwan Kwon, Ha-Ryong Kim, Jong-Hwan Kwak, Kyu-Hyuck Chung. Dendropanoxide, a Triterpenoid from Dendropanax morbifera, Ameliorates Hepatic Fibrosis by Inhibiting Activation of Hepatic Stellate Cells through Autophagy Inhibition. Nutrients. 2021 Dec; 14(1):. doi: 10.3390/nu14010098. [PMID: 35010975]
  • Sarwan W Bradosty, Saber W Hamad, Nabaz Fisal Shakir Agha, Faiyaz Khudaboddin Shaikh, Nadir Mustafa Qadir Nanakali, Peshawa Yunis Aziz, Nur'Ain Salehen, Faruk Suzergoz, Mahmood Ameen Abdulla. In vivo hepatoprotective effect of Morinda elliptica stem extract against liver fibrosis induced by thioacetamide. Environmental toxicology. 2021 Dec; 36(12):2404-2413. doi: 10.1002/tox.23353. [PMID: 34436826]
  • Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin, Chien-Ming Hsieh. CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas. Drug delivery. 2021 Dec; 28(1):2205-2217. doi: 10.1080/10717544.2021.1989087. [PMID: 34662257]
  • Samah Ali El-Newary, Rasha Fouad Ismail, Nermeen Mohammed Shaffie, Saber Fayez Hendawy, Elsayed Omer, Mahgoub Mohammed Ahmed, Wael M ELsayed. Hepatoprotective effects of Tagetes lucida root extract in carbon tetrachloride-induced hepatotoxicity in Wistar albino rats through amelioration of oxidative stress. Pharmaceutical biology. 2021 Dec; 59(1):986-997. doi: 10.1080/13880209.2021.1949024. [PMID: 34347571]
  • Masoumeh Asgharpour, Amirhesam Alirezaei. Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications. Renal failure. 2021 Dec; 43(1):351-361. doi: 10.1080/0886022x.2021.1880939. [PMID: 33593237]
  • Qianqian Zhang, Je Min Ahn, In Ho Kim. Micelle silymarin supplementation to sows' diet from day 109 of gestation to entire lactation period enhances reproductive performance and affects serum hormones and metabolites. Journal of animal science. 2021 Dec; 99(12):. doi: 10.1093/jas/skab354. [PMID: 34850001]
  • Rong-Rui Wei, Qin-Ge Ma. Flavonolignan 2, 3-dehydroderivatives from Oenanthe javanica and their anti inflammatory activities. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2021 Nov; 76(11-12):459-465. doi: 10.1515/znc-2021-0001. [PMID: 34002579]
  • Kamila Bechynska, Vit Kosek, Marie Fenclova, Lucie Muchova, Vaclav Smid, Jakub Suk, Karel Chalupsky, Eva Sticova, Kamila Hurkova, Jana Hajslova, Libor Vitek, Milena Stranska. The Effect of Mycotoxins and Silymarin on Liver Lipidome of Mice with Non-Alcoholic Fatty Liver Disease. Biomolecules. 2021 11; 11(11):. doi: 10.3390/biom11111723. [PMID: 34827721]
  • Woojae Hong, Jeon Hwang-Bo, Hyelin Jeon, Minsung Ko, Joongyeon Choi, Yong-Joon Jeong, Jae-Hyun Park, Inhye Kim, Tae-Woo Kim, Hyunggun Kim, Se-Chan Kang. A Comparative Study of the Hepatoprotective Effect of Centella asiatica Extract (CA-HE50) on Lipopolysaccharide/d-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice. Nutrients. 2021 Nov; 13(11):. doi: 10.3390/nu13114090. [PMID: 34836346]
  • Mabrouk Attia Abd Eldaim, Eman Ragab Barakat, Mohamed Alkafafy, Samy Ahmed Abd Elaziz. Antioxidant and anti-apoptotic prophylactic effect of silymarin against lead-induced hepatorenal toxicity in rats. Environmental science and pollution research international. 2021 Nov; 28(41):57997-58006. doi: 10.1007/s11356-021-14722-8. [PMID: 34100211]
  • Hadi Darvishi-Khezri, Mohammad Naderisorki, Mohammad Zahedi, Parham Mortazavi, Fatemeh Tajik, Amirreza Nasirzadeh, Hossein Karami. Coadministration of silymarin with iron chelators in transfusion-dependent β-thalassemia patients: a systematic review and meta-analysis for effect on iron overload. Expert review of clinical pharmacology. 2021 Nov; 14(11):1445-1453. doi: 10.1080/17512433.2021.1964953. [PMID: 34486906]
  • Asif Shahzad, Muhammad Naeem Faisal, Ghulam Hussain, Syed Ali Raza Naqvi, Haseeb Anwar. Therapeutic potential of quinoa seed extract as regenerative and hepatoprotective agent in induced liver injury wistar rat model. Pakistan journal of pharmaceutical sciences. 2021 Nov; 34(6(Supplementary)):2309-2315. doi: ". [PMID: 35039268]
  • Josif Vidimce, Evan Noel Pennell, Maxmilian Foo, Ryan Graeme Shiels, Sapha Shibeeb, Michael Watson, Andrew Cameron Bulmer. Effect of Silymarin Treatment on Circulating Bilirubin and Cardiovascular Disease Risk Factors in Healthy Men: A Single-Blind, Randomized Crossover Trial. Clinical pharmacology in drug development. 2021 10; 10(10):1156-1165. doi: 10.1002/cpdd.962. [PMID: 34242497]
  • Maryam Fallah, Amirhossein Davoodvandi, Shahin Nikmanzar, Sarehnaz Aghili, Seyed Mohammad Ali Mirazimi, Michael Aschner, Amir Rashidian, Michael R Hamblin, Mohsen Chamanara, Navid Naghsh, Hamed Mirzaei. Silymarin (milk thistle extract) as a therapeutic agent in gastrointestinal cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112024. doi: 10.1016/j.biopha.2021.112024. [PMID: 34399200]
  • Rongsheng Wang, Jinji Mu. Arbutin attenuates ethanol-induced acute hepatic injury by the modulation of oxidative stress and Nrf-2/HO-1 signaling pathway. Journal of biochemical and molecular toxicology. 2021 Oct; 35(10):e22872. doi: 10.1002/jbt.22872. [PMID: 34346143]