Dehydrolithocholic acid (BioDeep_00000003938)

   

Bile acids


代谢物信息卡片


3-Oxo-5α-cholan-24-oic Acid

  化学式: C24H38O3 (374.2821)
中文名称:
  谱图信息: 最多检出来源 Homo sapiens(plant) 7.69%

分子结构信息

SMILES: CC(CCC(=O)O)C1CCC2C1(CCC3C2CCC4C3(CCC(=O)C4)C)C
InChI: InChI=1S/C24H38O3/c1-15(4-9-22(26)27)19-7-8-20-18-6-5-16-14-17(25)10-12-23(16,2)21(18)11-13-24(19,20)3/h15-16,18-21H,4-14H2,1-3H3,(H,26,27)

描述信息

D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids

同义名列表

60 个代谢物同义名

Dehydrolithocholic acid; 3-Oxo-5α-cholan-24-oic Acid; 3-Ketocholanic acid; 3-Oxo-5beta-cholanate; (4R)-4-[(5R,8R,9S,10S,13R,14S,17R)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid; (5-beta)-3-Oxocholan-24-oic acid; (5beta,9beta)-3-Oxocholan-24-Oic Acid; (5beta)-3-Oxo-Cholan-24-Oic Acid; 3-keto LCA; 3-keto Lithocholate; 3-keto lithocholic acid; 3-keto-5 beta-cholanoic acid; 3-KETO-5.BETA.-CHOLAN-24-OIC ACID; 3-Keto-5.beta.-cholanic acid; 3-KETO-5BETA-CHOLAN-24-OIC ACID; 3-Keto-5beta-cholanic acid; 3-keto-5beta-cholanoic acid; 3-keto-LCA; 3-keto-lithocholic acid; 3-ketocholanoic acid; 3-Ketolithocholic acid; 3-KLCA; 3-oxo LCA; 3-oxo Lithocholate; 3-oxo lithocholic acid; 3-oxo-5 beta-cholan-24-oic acid; 3-Oxo-5-beta-cholan-24-oic acid; 3-Oxo-5-cholanoic acid; 3-Oxo-5??-cholanoic acid; 3-Oxo-5.beta.-cholan-24-oic acid; 3-Oxo-5|A-cholanoic Acid; 3-Oxo-5b-cholanoic Acid; 3-Oxo-5beta-cholan-24-oic Acid; 3-oxo-5beta-cholanic acid; 3-Oxo-5beta-cholanoic Acid; 3-oxo-lithocholic acid; 3-oxocholan-24-oic acid; 3-Oxocholan-24-oic acid, (5.beta.)-; 3-Oxocholanic acid; 3-Oxolithocholic acid; 3KL; 5-beta-Cholan-24-oic acid, 3-oxo-; 5-beta-Cholanic acid-3-one; 5.beta.-Cholan-24-oic acid, 3-oxo-; 5.beta.-Cholanic acid-3-one; 5.BETA.-CHOLANIC ACID, 3-OXO-; 5BETA-CHOLAN-24-OIC ACID, 3-OXO-; 5beta-Cholanic acid-3-one; 5BETA-CHOLANIC ACID, 3-OXO-; 96JBM35FXF; Cholan-24-oic acid, 3-oxo-, (5-beta)-; Cholan-24-oic acid, 3-oxo-, (5-beta)-(9CI); Cholan-24-oic acid, 3-oxo-, (5.beta.)-; Cholan-24-oic acid, 3-oxo-, (5beta)-; Dehydrolithocholic acid; 5|A-cholanic acid-3-one; Dehydrolithocholic acid;3-oxoLCA; DHLCA; Lithocholic acid, dehydro-; UNII-96JBM35FXF; 4-(10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl)pentanoic acid



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CYP2D6, CYP3A4, FGF19, FOXP3, GPBAR1, NLRP3, PNPLA2, PTEN
Peripheral membrane protein 3 CYP1B1, CYP27A1, PLOD2
Endoplasmic reticulum membrane 9 CD4, CYP1B1, CYP2D6, CYP3A4, CYP7A1, CYP7B1, CYP8B1, PLOD2, PNPLA2
Mitochondrion membrane 1 CYP27A1
Nucleus 4 FOXP3, NLRP3, PPARA, PTEN
cytosol 4 FOXP3, NLRP3, PNPLA2, PTEN
nucleoplasm 4 FOXP3, PNPLA2, PPARA, PTEN
Cell membrane 5 CD4, GPBAR1, PNPLA2, SLC10A1, TNF
Multi-pass membrane protein 4 CYP7B1, GPBAR1, PNPLA2, SLC10A1
Golgi apparatus membrane 1 NLRP3
cell surface 1 TNF
Golgi membrane 1 NLRP3
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 1 TNF
Cytoplasm, cytosol 1 NLRP3
plasma membrane 7 CD4, GPBAR1, PNPLA2, PTEN, SLC10A1, SLC10A2, TNF
Membrane 7 CYP1B1, CYP2D6, CYP3A4, CYP7B1, NLRP3, PNPLA2, SLC10A1
apical plasma membrane 2 PTEN, SLC10A2
basolateral plasma membrane 1 SLC10A1
extracellular exosome 1 PLOD2
Lumenal side 1 PLOD2
endoplasmic reticulum 3 CYP2D6, NLRP3, PLOD2
extracellular space 3 FGF19, IL17A, TNF
mitochondrion 4 CYP1B1, CYP27A1, CYP2D6, NLRP3
protein-containing complex 1 FOXP3
intracellular membrane-bounded organelle 4 CYP1B1, CYP2D6, CYP3A4, CYP7A1
Microsome membrane 6 CYP1B1, CYP2D6, CYP3A4, CYP7A1, CYP7B1, CYP8B1
postsynaptic density 1 PTEN
Single-pass type I membrane protein 1 CD4
Secreted 2 IL17A, NLRP3
extracellular region 5 FGF19, IL17A, NLRP3, PTEN, TNF
cytoplasmic side of plasma membrane 1 PTEN
Single-pass membrane protein 3 CYP2D6, CYP7A1, CYP8B1
mitochondrial matrix 1 CYP27A1
external side of plasma membrane 3 CD4, IL17A, TNF
dendritic spine 1 PTEN
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 2 CD4, TNF
Cell projection, dendritic spine 1 PTEN
Nucleus, PML body 1 PTEN
PML body 1 PTEN
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
receptor complex 1 GPBAR1
Cell projection, neuron projection 1 PTEN
neuron projection 1 PTEN
chromatin 2 FOXP3, PPARA
cell projection 1 PTEN
phagocytic cup 1 TNF
Endomembrane system 1 NLRP3
microvillus 1 SLC10A2
Lipid droplet 1 PNPLA2
microtubule organizing center 1 NLRP3
endoplasmic reticulum lumen 2 CD4, PNPLA2
rough endoplasmic reticulum membrane 1 PLOD2
Schmidt-Lanterman incisure 1 PTEN
clathrin-coated endocytic vesicle membrane 1 CD4
Rough endoplasmic reticulum 1 PLOD2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
myelin sheath adaxonal region 1 PTEN
[Isoform alpha]: Secreted 1 PTEN
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
  • Anand K Deo, Stelvio M Bandiera. Biotransformation of lithocholic acid by rat hepatic microsomes: metabolite analysis by liquid chromatography/mass spectrometry. Drug metabolism and disposition: the biological fate of chemicals. 2008 Feb; 36(2):442-51. doi: 10.1124/dmd.107.017533. [PMID: 18039809]
  • Ryutaro Adachi, Yoshio Honma, Hiroyuki Masuno, Katsuyoshi Kawana, Iichiro Shimomura, Sachiko Yamada, Makoto Makishima. Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative. Journal of lipid research. 2005 Jan; 46(1):46-57. doi: 10.1194/jlr.m400294-jlr200. [PMID: 15489543]
  • R W Owen, R F Bilton. Metabolism of unsaturated bile acids and androstanes by human faecal bacteria. Journal of steroid biochemistry. 1985 Jun; 22(6):817-22. doi: 10.1016/0022-4731(85)90291-2. [PMID: 4021485]


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