Rubrofusarin (BioDeep_00000003931)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1\C15H12O5\c1-7-3-10(16)14-12(20-7)5-8-4-9(19-2)6-11(17)13(8)15(14)18\h3-6,17-18H,1-2H

化学式: C15H12O5 (272.0685)
中文名称: 镰刀菌丝红素, 红霉素
谱图信息: 最多检出来源 Viridiplantae(plant) 23.33%

分子结构信息

SMILES: CC1=CC(=O)C2=C(C3=C(C=C(C=C3C=C2O1)OC)O)O
InChI: InChI=1S/C15H12O5/c1-7-3-10(16)14-12(20-7)5-8-4-9(19-2)6-11(17)13(8)15(14)18/h3-6,17-18H,1-2H3

描述信息

A member of the class of benzochromenones that is benzo[g]chromen-4-one carrying two additional hydroxy substituents at positions 5 and 6 as well as methyl and methoxy substituents at positions 2 and 8 respectively. An orange polyketide pigment that is a common intermediate in many different fungal biosynthetic pathways.
CONFIDENCE Culture of Fusarium graminearum from DAOM

同义名列表

18 个代谢物同义名

Rubrofusarin; InChI=1\C15H12O5\c1-7-3-10(16)14-12(20-7)5-8-4-9(19-2)6-11(17)13(8)15(14)18\h3-6,17-18H,1-2H; 4H-Naphtho(2,3-b)pyran-4-one, 5,6-dihydroxy-8-methoxy-2-methyl- (8CI)(9CI); 4H-Naphtho[2,3-b]pyran-4-one, 5,6-dihydroxy-8-methoxy-2-methyl-; 5,6-Dihydroxy-8-methoxy-2-methyl-4H-naphtho[2,3-b]pyran-4-one; 5,6-dihydroxy-8-methoxy-2-methyl-4H-benzo[g]chromen-4-one; 5,6-Dihydroxy-8-methoxy-2-methyl-benzo[g]chromen-4-one; 5,6-dihydroxy-8-methoxy-2-methyl-4-benzo[g]chromenone; 5,6-dihydroxy-8-methoxy-2-methylbenzo[g]chromen-4-one; RUBRAFUSARIN; AIDS-010669; AIDS010669; NSC 258316; NSC258316; 3567-00-8; C09047; Rubrofusarin; Rubrofusarin



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

56 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ADIG, AIMP2, AKT1, CASP3, CYP3A4, DCX, GFAP, IRS1, MTOR, PIK3CA, PPARG, PYCARD, TYR
Peripheral membrane protein 1 MTOR
Endosome membrane 1 BACE1
Endoplasmic reticulum membrane 2 CYP3A4, MTOR
Mitochondrion membrane 1 MAOA
Nucleus 9 ADIG, AIMP2, AKT1, CASP3, CEBPD, IRS1, MTOR, PPARG, PYCARD
cytosol 12 AIMP2, AKT1, CASP3, DCX, GFAP, IRS1, MAOA, MTHFR, MTOR, PIK3CA, PPARG, PYCARD
dendrite 2 BACE1, MTOR
phagocytic vesicle 1 MTOR
trans-Golgi network 1 BACE1
nucleoplasm 7 AKT1, CASP3, CEBPD, IRS1, MTOR, PPARG, PYCARD
RNA polymerase II transcription regulator complex 2 CEBPD, PPARG
Cell membrane 2 AKT1, BACE1
Cytoplasmic side 2 MAOA, MTOR
lamellipodium 2 AKT1, PIK3CA
Cell projection, axon 1 BACE1
Golgi apparatus membrane 2 MTOR, PYCARD
cell cortex 1 AKT1
cell surface 1 BACE1
glutamatergic synapse 3 AKT1, CASP3, DCX
Golgi apparatus 1 BACE1
Golgi membrane 3 INS, MTOR, PYCARD
lysosomal membrane 2 GAA, MTOR
neuronal cell body 3 BACE1, CASP3, PYCARD
postsynapse 1 AKT1
synaptic vesicle 1 BACE1
Cytoplasm, cytosol 1 AIMP2
Lysosome 4 BACE1, GAA, MTOR, TYR
endosome 1 BACE1
plasma membrane 6 AKT1, BACE1, BCHE, GAA, IRS1, PIK3CA
Membrane 8 ADIG, AIMP2, AKT1, BACE1, CYP3A4, GAA, MAOA, MTOR
axon 1 BACE1
caveola 1 IRS1
extracellular exosome 1 GAA
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 2 BACE1, PYCARD
extracellular space 2 BCHE, INS
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 3 PIK3CA, PPARG, TYR
intercalated disc 1 PIK3CA
mitochondrion 2 MAOA, PYCARD
protein-containing complex 2 AKT1, PYCARD
intracellular membrane-bounded organelle 5 CYP3A4, GAA, IRS1, PPARG, TYR
Microsome membrane 2 CYP3A4, MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 BACE1, TYR
Secreted 4 ADIG, BCHE, GAA, INS
extracellular region 5 ADIG, BCHE, GAA, INS, PYCARD
Mitochondrion outer membrane 2 MAOA, MTOR
Single-pass membrane protein 2 ADIG, MAOA
mitochondrial outer membrane 2 MAOA, MTOR
astrocyte end-foot 1 GFAP
hippocampal mossy fiber to CA3 synapse 1 BACE1
multivesicular body 1 BACE1
microtubule cytoskeleton 1 AKT1
nucleolus 1 PYCARD
Melanosome membrane 1 TYR
Early endosome 1 BACE1
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 BACE1
vesicle 1 AKT1
Membrane raft 1 BACE1
microtubule 2 DCX, PYCARD
spindle 1 AKT1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
intermediate filament 1 GFAP
Inflammasome 1 PYCARD
NLRP3 inflammasome complex 1 PYCARD
Late endosome 1 BACE1
receptor complex 1 PPARG
Cell projection, neuron projection 1 DCX
neuron projection 1 DCX
ciliary basal body 1 AKT1
chromatin 2 CEBPD, PPARG
microtubule associated complex 1 DCX
cell projection 1 GFAP
cytoskeleton 1 DCX
Golgi apparatus, trans-Golgi network 1 BACE1
blood microparticle 1 BCHE
nuclear envelope 1 MTOR
Endomembrane system 2 BACE1, MTOR
endosome lumen 1 INS
Lipid droplet 1 ADIG
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
tertiary granule membrane 1 GAA
Melanosome 1 TYR
cell body 1 GFAP
intermediate filament cytoskeleton 1 GFAP
secretory granule lumen 2 INS, PYCARD
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BACE1, BCHE, INS
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 PYCARD
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 MAOA
nuclear envelope lumen 1 BCHE
AIM2 inflammasome complex 1 PYCARD
IkappaB kinase complex 1 PYCARD
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
canonical inflammasome complex 1 PYCARD
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cytoplasmic vesicle, phagosome 1 MTOR
cytoplasmic side of lysosomal membrane 1 GFAP
insulin receptor complex 1 IRS1
autolysosome lumen 1 GAA
NLRP1 inflammasome complex 1 PYCARD
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
Golgi-associated vesicle lumen 1 BACE1
NLRP6 inflammasome complex 1 PYCARD


文献列表

  • Noha Fathalla, Mokhtar Bishr, Abdel Nasser Singab, Osama Salama. GC-MS and LC-MS Identification of the Phenolic Compounds Present in the ethyl Acetate Fraction Obtained from Senna tora, L. Roxb. seeds. Natural product research. 2019 Oct; 33(19):2878-2881. doi: 10.1080/14786419.2018.1508138. [PMID: 30445876]
  • Yuejiao Li, Ming Wang, Zhaohui Liu, Kang Zhang, Fuhao Cui, Wenxian Sun. Towards understanding the biosynthetic pathway for ustilaginoidin mycotoxins in Ustilaginoidea virens. Environmental microbiology. 2019 08; 21(8):2629-2643. doi: 10.1111/1462-2920.14572. [PMID: 30807673]
  • Srijan Shrestha, Su Hui Seong, Pradeep Paudel, Hyun Ah Jung, Jae Sue Choi. Structure Related Inhibition of Enzyme Systems in Cholinesterases and BACE1 In Vitro by Naturally Occurring Naphthopyrone and Its Glycosides Isolated from Cassia obtusifolia. Molecules (Basel, Switzerland). 2017 Dec; 23(1):. doi: 10.3390/molecules23010069. [PMID: 29283428]
  • Yongshuai Jing, Juan Yang, Lanfang Wu, Zhendong Zhang, Li Fang. [Rubrofusarin glucosides of Berchemia polyphylla var. leioclada and their scavenging activities for DPPH radical]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Aug; 36(15):2084-7. doi: . [PMID: 22066444]
  • Hong-Bo Huang, Xiao-Jun Feng, Lan Liu, Bin Chen, Yong-Jun Lu, Lin Ma, Zhi-Gang She, Yong-Cheng Lin. Three dimeric naphtho-γ-pyrones from the mangrove endophytic fungus Aspergillus tubingensis isolated from Pongamia pinnata. Planta medica. 2010 Nov; 76(16):1888-91. doi: 10.1055/s-0030-1249955. [PMID: 20506081]
  • Ali Mahmoud El-Halawany, Mi Hwa Chung, Norio Nakamura, Chao-Mei Ma, Tsutomu Nishihara, Masao Hattori. Estrogenic and anti-estrogenic activities of Cassia tora phenolic constituents. Chemical & pharmaceutical bulletin. 2007 Oct; 55(10):1476-82. doi: 10.1248/cpb.55.1476. [PMID: 17917292]
  • Tae Hyun Park, Dae Hyun Kim, Chul Hong Kim, Hyun Ah Jung, Jae Sue Choi, Jae Won Lee, Hae Young Chung. Peroxynitrite scavenging mode of alaternin isolated from Cassia tora. The Journal of pharmacy and pharmacology. 2004 Oct; 56(10):1315-21. doi: 10.1211/0022357044229. [PMID: 15482647]
  • James G Graham, Hongjie Zhang, Susan L Pendland, Bernard D Santarsiero, Andrew D Mesecar, Fernando Cabieses, Norman R Farnsworth. Antimycobacterial Naphthopyrones from Senna obliqua. Journal of natural products. 2004 Feb; 67(2):225-7. doi: 10.1021/np030348i. [PMID: 14987063]
  • X C Li, D C Dunbar, H N ElSohly, M R Jacob, A C Nimrod, L A Walker, A M Clark. A new naphthopyrone derivative from Cassia quinquangulata and structural revision of quinquangulin and its glycosides. Journal of natural products. 2001 Sep; 64(9):1153-6. doi: 10.1021/np010173h. [PMID: 11575947]