Astragaloside (BioDeep_00000000392)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4,7-dihydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethylhexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-9-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

化学式: C41H68O14 (784.4609)
中文名称: 黄芪皂苷 III, 黄芪皂苷III
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 50%

分子结构信息

SMILES: CC(C)(O)C1CCC(C)(C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(OC6OCC(O)C(O)C6OC6OC(CO)C(O)C(O)C6O)CCC56CC46CCC23C)O1
InChI: InChI=1S/C41H68O14/c1-35(2)24(53-34-30(26(46)21(45)17-51-34)54-33-29(49)28(48)27(47)22(16-42)52-33)9-11-41-18-40(41)13-12-37(5)32(39(7)10-8-25(55-39)36(3,4)50)20(44)15-38(37,6)23(40)14-19(43)31(35)41/h19-34,42-50H,8-18H2,1-7H3/t19-,20-,21+,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34-,37+,38-,39+,40-,41+/m0/s1

描述信息

Astragaloside III is a triterpenoid saponin that is cycloastragenol with a 2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl moiety attached at position 3 via a glycosidic linkage. It is a triterpenoid saponin and a disaccharide derivative. It is functionally related to a cycloastragenol.
Astragaloside III is a natural product found in Astragalus hoantchy, Astragalus lehmannianus, and other organisms with data available.
See also: Astragalus propinquus root (part of).
A triterpenoid saponin that is cycloastragenol with a 2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl moiety attached at position 3 via a glycosidic linkage.
Astragaloside III is a natural product isolated from Astragalus.
Astragaloside III is a natural product isolated from Astragalus.

同义名列表

12 个代谢物同义名

(2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4,7-dihydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethylhexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-9-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-9,14-dihydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-4,5-dihydroxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; .BETA.-D-XYLOPYRANOSIDE, (3.BETA.,6.ALPHA.,16.BETA.,20R,24S)-20,24-EPOXY-6,16,25-TRIHYDROXY-9,19-CYCLOLANOSTAN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; (3beta,6alpha,9beta,16beta,20R,24S)-6,16,25-trihydroxy-20,24-epoxy-9,19-cyclolanostan-3-yl 2-O-beta-D-glucopyranosyl-beta-D-xylopyranoside; beta-D-Xylopyranoside, (3beta,6alpha,16beta,20R,24S)-20,24-epoxy-6,16,25-trihydroxy-9,19-cyclolanostan-3-yl 2-o-beta-D-glucopyranosyl-; Astragaloside III (constituent of astragalus) [DSC]; Astragaloside III (constituent of astragalus); astragaloside III; Astragaloside-III; Astragaloside; Astragaloside cento; Astragaloside III



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ADAM17, AIMP2, ANXA1, BCL2, CASP3, CCND1, EGFR, HIF1A, MAPK8, MDM2, MTOR, PIK3CA, VEGFA
Peripheral membrane protein 2 ANXA1, MTOR
Endosome membrane 2 ANXA1, EGFR
Endoplasmic reticulum membrane 3 BCL2, EGFR, MTOR
Nucleus 14 AIMP2, ANXA1, BCL2, CASP3, CCND1, DDX53, EGFR, HIF1A, MAPK8, MDM2, MTOR, PARP1, TBX21, VEGFA
cytosol 13 ADAM17, AIMP2, ANXA1, BCL2, CASP3, CCND1, DDX53, HIF1A, MAPK8, MDM2, MTOR, PARP1, PIK3CA
dendrite 1 MTOR
nuclear body 2 HIF1A, PARP1
phagocytic vesicle 1 MTOR
centrosome 1 CCND1
nucleoplasm 9 ANXA1, CASP3, CCND1, DDX53, HIF1A, MAPK8, MDM2, MTOR, PARP1
RNA polymerase II transcription regulator complex 1 HIF1A
Cell membrane 4 ADAM17, ANXA1, EGFR, TNFRSF1A
Cytoplasmic side 1 MTOR
lamellipodium 1 PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 2 ANXA1, EGFR
Golgi apparatus membrane 2 MTOR, TNFRSF1A
Synapse 1 MAPK8
cell junction 1 EGFR
cell surface 5 ADAM17, ANXA1, EGFR, TNFRSF1A, VEGFA
glutamatergic synapse 3 CASP3, EGFR, MDM2
Golgi apparatus 1 VEGFA
Golgi membrane 4 ADAM17, EGFR, MTOR, TNFRSF1A
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TBX21
sarcolemma 1 ANXA1
Cytoplasm, cytosol 2 AIMP2, PARP1
Lysosome 1 MTOR
endosome 2 ANXA1, EGFR
plasma membrane 7 ADAM17, ANXA1, EGFR, IFNLR1, MDM2, PIK3CA, TNFRSF1A
Membrane 10 ADAM17, AIMP2, ANXA1, BCL2, EGFR, IFNLR1, MTOR, PARP1, TNFRSF1A, VEGFA
apical plasma membrane 3 ADAM17, ANXA1, EGFR
axon 2 CCK, MAPK8
basolateral plasma membrane 2 ANXA1, EGFR
extracellular exosome 2 ANXA1, BMP3
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 BCL2, VEGFA
extracellular space 6 ANXA1, BMP3, CCK, EGFR, TNFRSF1A, VEGFA
perinuclear region of cytoplasm 2 EGFR, PIK3CA
adherens junction 2 ANXA1, VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, PARP1
protein-containing complex 5 BCL2, EGFR, HIF1A, MDM2, PARP1
intracellular membrane-bounded organelle 1 DDX53
Microsome membrane 1 MTOR
postsynaptic density 2 CASP3, MDM2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 4 ADAM17, EGFR, IFNLR1, TNFRSF1A
Secreted 5 ANXA1, BMP3, CCK, TNFRSF1A, VEGFA
extracellular region 5 ANXA1, BMP3, CCK, TNFRSF1A, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Extracellular side 1 ANXA1
transcription regulator complex 1 PARP1
Cell projection, cilium 1 ANXA1
motile cilium 2 ANXA1, HIF1A
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CCND1, EGFR
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ADAM17
nucleolus 3 DDX53, MDM2, PARP1
axon cytoplasm 1 HIF1A
Early endosome 1 ANXA1
vesicle 1 ANXA1
Apical cell membrane 1 ANXA1
Membrane raft 3 ADAM17, EGFR, TNFRSF1A
pore complex 1 BCL2
focal adhesion 2 ANXA1, EGFR
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 1 ANXA1
secretory granule 1 VEGFA
lateral plasma membrane 1 ANXA1
nuclear speck 1 HIF1A
receptor complex 2 EGFR, TNFRSF1A
cilium 1 ANXA1
chromatin 3 HIF1A, PARP1, TBX21
Cell projection, phagocytic cup 1 ANXA1
phagocytic cup 1 ANXA1
Chromosome 1 PARP1
Secreted, extracellular space 1 ANXA1
Nucleus, nucleolus 2 MDM2, PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
Basolateral cell membrane 1 ANXA1
site of double-strand break 1 PARP1
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
Cornified envelope 1 ANXA1
Cytoplasmic vesicle membrane 1 ANXA1
Nucleus, nucleoplasm 1 MDM2
Nucleus speckle 1 HIF1A
euchromatin 1 HIF1A
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
endoplasmic reticulum lumen 1 ADAM17
transcription repressor complex 2 CCND1, MDM2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 1 MDM2
Secreted, extracellular exosome 1 ANXA1
vesicle membrane 1 ANXA1
clathrin-coated endocytic vesicle membrane 1 EGFR
Lateral cell membrane 1 ANXA1
protein-DNA complex 1 PARP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Cytoplasmic vesicle, secretory vesicle lumen 1 ANXA1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
tumor necrosis factor receptor superfamily complex 1 TNFRSF1A
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
interleukin-28 receptor complex 1 IFNLR1


文献列表

  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Haifang Wang, Ruihua Yuan, Qingwen Cao, Mian Wang, Dezhi Ren, Xiaoyan Huang, Min Wu, Linping Zhang, Xiangrong Zhao, Xueping Huo, Yalei Pan, Qinshe Liu. Astragaloside III activates TACE/ADAM17-dependent anti-inflammatory and growth factor signaling in endothelial cells in a p38-dependent fashion. Phytotherapy research : PTR. 2020 May; 34(5):1096-1107. doi: 10.1002/ptr.6603. [PMID: 32197276]
  • Can-Jian Wang, Fan He, Yu-Feng Huang, Hong-Liang Ma, Ying-Ping Wang, Chun-Song Cheng, Jin-Le Cheng, Chi-Chou Lao, Di-An Chen, Zhi-Feng Zhang, Zhen Sang, Pei Luo, Sheng-Yuan Xiao, Ying Xie, Hua Zhou. Discovery of chemical markers for identifying species, growth mode and production area of Astragali Radix by using ultra-high-performance liquid chromatography coupled to triple quadrupole mass spectrometry. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Feb; 67(?):153155. doi: 10.1016/j.phymed.2019.153155. [PMID: 31901890]
  • Xiao-Hua Liu, Long Guo, Ying-Lai Yang, Fang Hu, Xin-Yue Chen, Shi-Lan Feng. Development and Validation of a Rapid and Simple UPLC-ESI-MS Method for Pharmacokinetics and Tissue Distribution of Astragaloside III in Rats. Journal of chromatographic science. 2016 May; 54(5):811-8. doi: 10.1093/chromsci/bmw021. [PMID: 26931734]
  • Yongsong Zhai, Pengyue Li, Manyuan Wang, Muxin Gong, Feng Qiu. Determination of astragaloside III in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. Biomedical chromatography : BMC. 2016 Feb; 30(2):105-10. doi: 10.1002/bmc.3521. [PMID: 26031660]
  • Mu Yongping, Xiao Zhang, Li Xuewei, Weiwei Fan, Jiamei Chen, Hua Zhang, Gaofeng Chen, Chenghai Liu, Ping Liu. Astragaloside prevents BDL-induced liver fibrosis through inhibition of notch signaling activation. Journal of ethnopharmacology. 2015 Jul; 169(?):200-9. doi: 10.1016/j.jep.2015.04.015. [PMID: 25917841]
  • Ha-Jeong Kwon, Jeehyun Hwang, Sun-Kyoung Lee, Yong-Duk Park. Astragaloside content in the periderm, cortex, and xylem of Astragalus membranaceus root. Journal of natural medicines. 2013 Oct; 67(4):850-5. doi: 10.1007/s11418-013-0741-8. [PMID: 23381847]
  • Wendy Li Zhang, Roy Chi-Yan Choi, Janis Ya-Xian Zhan, Jian-Ping Chen, Wilson Kin-Wai Luk, Ping Yao, Tina Ting-Xia Dong, Karl Wah-Keung Tsim. Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment?. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Sep; 20(12):1076-81. doi: 10.1016/j.phymed.2013.04.016. [PMID: 23746954]