Astragaloside (BioDeep_00000000392)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4,7-dihydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethylhexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-9-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

化学式: C41H68O14 (784.4608828)
中文名称: 黄芪皂苷 III, 黄芪皂苷III, 黄芪皂苷 III
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 25%

分子结构信息

SMILES: CC(C)(O)C1CCC(C)(C2C(O)CC3(C)C4CC(O)C5C(C)(C)C(OC6OCC(O)C(O)C6OC6OC(CO)C(O)C(O)C6O)CCC56CC46CCC23C)O1
InChI: InChI=1S/C41H68O14/c1-35(2)24(53-34-30(26(46)21(45)17-51-34)54-33-29(49)28(48)27(47)22(16-42)52-33)9-11-41-18-40(41)13-12-37(5)32(39(7)10-8-25(55-39)36(3,4)50)20(44)15-38(37,6)23(40)14-19(43)31(35)41/h19-34,42-50H,8-18H2,1-7H3/t19-,20-,21+,22+,23-,24-,25-,26-,27+,28-,29+,30+,31-,32-,33-,34-,37+,38-,39+,40-,41+/m0/s1

描述信息

Astragaloside III is a triterpenoid saponin that is cycloastragenol with a 2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl moiety attached at position 3 via a glycosidic linkage. It is a triterpenoid saponin and a disaccharide derivative. It is functionally related to a cycloastragenol.
Astragaloside III is a natural product found in Astragalus hoantchy, Astragalus lehmannianus, and other organisms with data available.
See also: Astragalus propinquus root (part of).
A triterpenoid saponin that is cycloastragenol with a 2-O-beta-D-glucopyranosyl-beta-D-xylopyranosyl moiety attached at position 3 via a glycosidic linkage.
Astragaloside III is a natural product isolated from Astragalus.
Astragaloside III is a natural product isolated from Astragalus.

同义名列表

11 个代谢物同义名

(2S,3R,4S,5S,6R)-2-(((2S,3R,4S,5R)-2-(((2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-4,7-dihydroxy-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethylhexadecahydrocyclopenta[a]cyclopropa[e]phenanthren-9-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-9,14-dihydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-4,5-dihydroxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; .BETA.-D-XYLOPYRANOSIDE, (3.BETA.,6.ALPHA.,16.BETA.,20R,24S)-20,24-EPOXY-6,16,25-TRIHYDROXY-9,19-CYCLOLANOSTAN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; (3beta,6alpha,9beta,16beta,20R,24S)-6,16,25-trihydroxy-20,24-epoxy-9,19-cyclolanostan-3-yl 2-O-beta-D-glucopyranosyl-beta-D-xylopyranoside; beta-D-Xylopyranoside, (3beta,6alpha,16beta,20R,24S)-20,24-epoxy-6,16,25-trihydroxy-9,19-cyclolanostan-3-yl 2-o-beta-D-glucopyranosyl-; Astragaloside III (constituent of astragalus) [DSC]; Astragaloside III (constituent of astragalus); astragaloside III; Astragaloside-III; Astragaloside; Astragaloside cento



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Haifang Wang, Ruihua Yuan, Qingwen Cao, Mian Wang, Dezhi Ren, Xiaoyan Huang, Min Wu, Linping Zhang, Xiangrong Zhao, Xueping Huo, Yalei Pan, Qinshe Liu. Astragaloside III activates TACE/ADAM17-dependent anti-inflammatory and growth factor signaling in endothelial cells in a p38-dependent fashion. Phytotherapy research : PTR. 2020 May; 34(5):1096-1107. doi: 10.1002/ptr.6603. [PMID: 32197276]
  • Can-Jian Wang, Fan He, Yu-Feng Huang, Hong-Liang Ma, Ying-Ping Wang, Chun-Song Cheng, Jin-Le Cheng, Chi-Chou Lao, Di-An Chen, Zhi-Feng Zhang, Zhen Sang, Pei Luo, Sheng-Yuan Xiao, Ying Xie, Hua Zhou. Discovery of chemical markers for identifying species, growth mode and production area of Astragali Radix by using ultra-high-performance liquid chromatography coupled to triple quadrupole mass spectrometry. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Feb; 67(?):153155. doi: 10.1016/j.phymed.2019.153155. [PMID: 31901890]
  • Xiao-Hua Liu, Long Guo, Ying-Lai Yang, Fang Hu, Xin-Yue Chen, Shi-Lan Feng. Development and Validation of a Rapid and Simple UPLC-ESI-MS Method for Pharmacokinetics and Tissue Distribution of Astragaloside III in Rats. Journal of chromatographic science. 2016 May; 54(5):811-8. doi: 10.1093/chromsci/bmw021. [PMID: 26931734]
  • Yongsong Zhai, Pengyue Li, Manyuan Wang, Muxin Gong, Feng Qiu. Determination of astragaloside III in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. Biomedical chromatography : BMC. 2016 Feb; 30(2):105-10. doi: 10.1002/bmc.3521. [PMID: 26031660]
  • Mu Yongping, Xiao Zhang, Li Xuewei, Weiwei Fan, Jiamei Chen, Hua Zhang, Gaofeng Chen, Chenghai Liu, Ping Liu. Astragaloside prevents BDL-induced liver fibrosis through inhibition of notch signaling activation. Journal of ethnopharmacology. 2015 Jul; 169(?):200-9. doi: 10.1016/j.jep.2015.04.015. [PMID: 25917841]
  • Ha-Jeong Kwon, Jeehyun Hwang, Sun-Kyoung Lee, Yong-Duk Park. Astragaloside content in the periderm, cortex, and xylem of Astragalus membranaceus root. Journal of natural medicines. 2013 Oct; 67(4):850-5. doi: 10.1007/s11418-013-0741-8. [PMID: 23381847]
  • Wendy Li Zhang, Roy Chi-Yan Choi, Janis Ya-Xian Zhan, Jian-Ping Chen, Wilson Kin-Wai Luk, Ping Yao, Tina Ting-Xia Dong, Karl Wah-Keung Tsim. Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment?. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Sep; 20(12):1076-81. doi: 10.1016/j.phymed.2013.04.016. [PMID: 23746954]