Methoxsalen (BioDeep_00000000387)

 

Secondary id: BioDeep_00000398586, BioDeep_00000861006

human metabolite PANOMIX_OTCML-2023 blood metabolite Chemicals and Drugs Volatile Flavor Compounds natural product


代谢物信息卡片


Methoxsalen, United States Pharmacopeia (USP) Reference Standard

化学式: C12H8O4 (216.0422568)
中文名称: 8-甲氧基补骨脂素, 8-甲氧补骨脂素, 8-甲氧基补骨酯, 甲氧基补骨脂素, 8-甲氧补骨脂, 甲氧补骨脂素, 花椒毒素, 甲氧沙林
谱图信息: 最多检出来源 Homo sapiens(blood) 0.26%

分子结构信息

SMILES: c12c(ccc(=O)o1)cc1c(c2OC)occ1
InChI: InChI=1S/C12H8O4/c1-14-12-10-8(4-5-15-10)6-7-2-3-9(13)16-11(7)12/h2-6H,1H3

描述信息

8-methoxypsoralen is an odorless white to cream-colored crystalline solid. Bitter taste followed by tingling sensation. (NTP, 1992)
Methoxsalen is a member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis. It has a role as a dermatologic drug, an antineoplastic agent, a photosensitizing agent, a cross-linking reagent and a plant metabolite. It is a member of psoralens and an aromatic ether. It is functionally related to a psoralen.
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.
Methoxsalen is a Photoactivated Radical Generator and Psoralen. The mechanism of action of methoxsalen is as a Photoabsorption. The physiologic effect of methoxsalen is by means of Photosensitizing Activity.
Methoxsalen is a natural product found in Ammi visnaga, Zanthoxylum mayu, and other organisms with data available.
Methoxsalen is a naturally occurring substance isolated from the seeds of the plant Ammi majus with photoactivating properties. As a member of the family of compounds known as psoralens or furocoumarins, methoxsalens exact mechanism of action is unknown; upon photoactivation, methoxsalen has been observed to bind covalently to and crosslink DNA. (NCI04)
Methoxsalen is only found in individuals that have used or taken this drug. It is a naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. After activation Methoxsalen binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA ADDUCTS in the presence of ultraviolet A irradiation.
See also: Angelica archangelica root (part of); Ammi majus seed (part of); Angelica keiskei top (part of) ... View More ...
Methoxsalen, also known as oxsoralen or 8-methoxypsoralen, belongs to the class of organic compounds known as 8-methoxypsoralens. These are psoralens containing a methoxy group attached at the C8 position of the psoralen group. Methoxsalen is a drug which is used for the treatment of psoriasis and vitiligo. Methoxsalen is a bitter tasting compound. Methoxsalen is found, on average, in the highest concentration within a few different foods, such as parsnips, parsley, and celery stalks and in a lower concentration in wild carrots, carrots, and fennels. Methoxsalen has also been detected, but not quantified, in several different foods, such as figs, green vegetables, corianders, dills, and fruits. Methoxsalen is a potentially toxic compound.
A member of the class of psoralens that is 7H-furo[3,2-g]chromen-7-one in which the 9 position is substituted by a methoxy group. It is a constituent of the fruits of Ammi majus. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered topically or orally in conjunction with UV-A for phototherapy treatment of vitiligo and severe psoriasis.
Present in celery, especies the outer leaves, and other common grocery vegetables. Implicated in photodermatitis among grocery workers. Isolated from Aegle marmelos (bael)
D - Dermatologicals > D05 - Antipsoriatics > D05B - Antipsoriatics for systemic use > D05BA - Psoralens for systemic use
D - Dermatologicals > D05 - Antipsoriatics > D05A - Antipsoriatics for topical use > D05AD - Psoralens for topical use
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents > D011564 - Furocoumarins
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
C1420 - Photosensitizing Agent
D003879 - Dermatologic Agents
[Raw Data] CBA87_Xanthotoxin_pos_20eV.txt
[Raw Data] CBA87_Xanthotoxin_pos_30eV.txt
[Raw Data] CBA87_Xanthotoxin_pos_40eV.txt
[Raw Data] CBA87_Xanthotoxin_pos_10eV.txt
[Raw Data] CBA87_Xanthotoxin_pos_50eV.txt
Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.
Methoxsalen (8-Methoxypsoralen) is a furanocoumarin compound used in psoralen, used in studies of psoriasis, eczema, vitiligo and some sun-exposed cutaneous lymphomas, and is a P450 inhibitor.

同义名列表

179 个代谢物同义名

Methoxsalen, United States Pharmacopeia (USP) Reference Standard; 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, .delta.-lactone; 5-BENZOFURANACRYLIC ACIDE, 6-HYDROXY-7-METHOXY-, DELTA-LACTONE; 5-Benzofuranacrylic acid, 6-hydroxy-7-methoxy-, delta-lactone; 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid delta-lactone; 6-Hydroxy-7-methoxy-5-benzofuranacrylic acid δ-lactone; 6-Hydroxy-7-methoxy-5-benzofuranacrylate delta-lactone; 6-Hydroxy-7-methoxy-5-benzofuranacrylate δ-lactone; 7H-Furo[3,2-g][1]benzopyran-7-one, 9-methoxy-; 7H-Furo(3,2-G)(1)benzopyran-7-one, 9-methoxy-; 5-19-06-00015 (Beilstein Handbook Reference); 8-Methoxypsoralen with ultraviolet A therapy; 9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one; 9-METHOXY-7H-FURO[3,2-G][1]BENZOPYRAN-7-ONE; 9-Methoxy-7H-furo(3,2-g)(1)benzopyran-7-one; Boehringer ingelheim brand OF methoxsalen; 9-(methyloxy)-7H-furo[3,2-g]chromen-7-one; 9-Methoxy-7H-furo(3,2-g)benzopyran-7-one; 9-Methoxy-7H-furo[3,2-g]chromen-7-one #; Sanofi-synthelabo brand OF methoxsalen; 8-Methoxypsoralen, analytical standard; Methoxsalen plus ultraviolet radiation; Sanofi synthelabo brand OF methoxsalen; 9-METHOXY-2H-FURO[3,2-G]CHROMEN-2-ONE; 9-Methoxy-7H-furo[3,2-g]chromen-7-one; 9-methoxy-7H-furo(3,2-g)chromen-7-one; 8-Methoxy-[furano-3.2:6.7-coumarin]; 8-Methoxypsoralen;Xanthotoxin;8-MOP; Methoxsalen sanofi-synthelabo brand; 8-Methoxy-(furano-3.2:6.7-coumarin); 8-methoxy-[furano-3.2:6.7-coumarin]; 9-methoxyfurano[3,2-g]chromen-2-one; 8-Methoxy(furano-3.2:6.7-coumarin); 9-Methoxy-furo[3,2-g]chromen-7-one; 8-Methoxy(furano-3,2:6,7-coumarin); 9-methoxyfuro[3,2-g]chromen-7-one; 9-Methoxyfuro(3,2-g)chromen-7-one; Xanthotoxin, analytical standard; Mex-america brand OF methoxsalen; Mex america brand OF methoxsalen; Methoxsalen (8-Methoxypsoralen); 8-methoxy-4,5:6,7-furocoumarin; 8-Methoxy-4,5:6,7-furocoumarin; Dermatech brand OF methoxsalen; 8-Methoxy-4,5,6,7-furocoumarin; 8-methoxy-2,3,6,7-furocoumarin; 8-Methoxy-2,3,6,7-furocoumarin; Galderma brand OF methoxsalen; Methoxsalen mex-america brand; Canderm brand OF methoxsalen; 8-Methoxy-4,6,7-furocoumarin; 8-Methoxy-2,6,7-furocoumarin; 8-Methoxy-6,7-furanocoumarin; Chinoin brand OF methoxsalen; METHOXSALEN [USP MONOGRAPH]; Methoxsalen dermatech brand; METHOXSALEN (USP MONOGRAPH); SM-88 COMPONENT METHOXSALEN; Delta Brand OF methoxsalen; 8-MOP;Xanthotoxin;Ammoidin; ICN brand 3 OF methoxsalen; ICN brand 1 OF methoxsalen; ICN brand 2 OF methoxsalen; Methoxsalen chinoin brand; Methoxsalen canderm brand; Methoxsalen (USP:BAN:JAN); Xanthotoxin (Methoxsalen); METHOXSALEN [ORANGE BOOK]; Methoxsalen [USP:BAN:JAN]; DB Brand OF methoxsalen; Methoxsalen Delta brand; 8-Methoxyfuranocoumarin; Methoxsalen (Oxsoralen); Methoxsalen (JP17/USP); 7H-Furo[3, 9-methoxy-; 8-Methoxy-d3 Psoralen; METHOXSALEN (USP-RS); METHOXSALEN [WHO-DD]; METHOXSALEN [USP-RS]; O-methylxanthotoxol; METHOXSALEN (MART.); METHOXSALEN [MART.]; METHOXSALEN [VANDF]; Methoxy-8-psoralen; 8-Methoxypsoralene; 8-methoxy psoralen; METHOXSALEN (IARC); METHOXSALEN [IARC]; METHOXSALEN [HSDB]; Prestwick1_000479; Prestwick0_000479; 8 Methoxypsoralen; 9-Methoxypsoralen; Prestwick3_000479; METHOXSALEN [JAN]; Prestwick2_000479; 8-Methoxypsoralen; Methoxsalen-13CD3; Spectrum3_000499; Spectrum2_001052; Spectrum4_000052; METHOXSALEN [MI]; Oxsoralen lotion; Spectrum5_001891; Meladinin (VAN); Oxsoralen Ultra; Oxsoralen-ultra; Methoxsalen, 8-; UNII-U4VJ29L7BQ; methoxypsoralen; Oxoralen-Ultra; Tox21_110432_1; OXSORALEN (TN); 7-Furocoumarin; Deltapsoralen; MEGxp0_000095; 8-methoxsalen; DivK1c_000763; Proralone-mop; Oprea1_166319; New-Meladinin; BPBio1_000680; Tox21_110432; NCI60_004085; Tox21_302816; ACon1_000174; Methoxsalene; Deltasoralen; Methoxa-Dome; KBio2_001503; Methoxa Dome; KBio1_000763; Tox21_201767; Psoralon-MOP; KBio3_001497; KBio2_004071; KBio2_006639; Xanthotoxine; Psoralen-mop; Methoxsalen; Oxypsoralen; UVADEX (TN); Puvasoralen; Dltasoralen; IDI1_000763; Xanthotoxin; Zanthotoxin; Metoxaleno; Meladinina; Méladinine; U4VJ29L7BQ; Methoxaten; Mopsoralen; Meladinine; Methoxalen; Meladoxen; Ultra Mop; Xanthoxin; Metoxalen; Geroxalen; Oxsoralen; Meladinin; Meloxine; Ammoidin; Ultramop; Oxoralen; Puvamet; Puvalen; Ammodin; Dermox; Uvadex; Vitpso; 8 MOP; 8-MOP; 8MOP; 8-MP; 8MO; Xanthotoxin; Methoxsalen



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

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BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

478 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Oleg A Kulikov, Vasilisa I Shlyapkina, Ekaterina P Brodovskaya, Amina M Al-Khadj Aioub, Valentin P Ageev, Mikhail N Zharkov, Denis E Yakobson, Daniil S Sokushev, Nikolay A Pyataev, Gleb B Sukhorukov. Phototoxicity in vitro and safety in vivo of the emulsion photosensitizer based on furanocoumarins of Heracleum sosnowskyi. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 May; 198(?):114257. doi: 10.1016/j.ejpb.2024.114257. [PMID: 38479564]
  • Kasemsiri Chandarajoti, Jiraporn Kara, Paptawan Suwanhom, Teerapat Nualnoi, Jindaporn Puripattanavong, Vannajan Sanghiran Lee, Varomyalin Tipmanee, Luelak Lomlim. Synthesis and evaluation of coumarin derivatives on antioxidative, tyrosinase inhibitory activities, melanogenesis, and in silico investigations. Scientific reports. 2024 03; 14(1):5535. doi: 10.1038/s41598-024-54665-x. [PMID: 38448547]
  • Tianxiang Xiao, Zhiming Yang, Wenxiu Wang, Mengqing Deng, Haoxue Peng, Zifan Huang, Jianping Liu, Kai Lu. Role of the epsilon glutathione S-transferases in xanthotoxin tolerance in Spodoptera litura. Pesticide biochemistry and physiology. 2023 Nov; 196(?):105592. doi: 10.1016/j.pestbp.2023.105592. [PMID: 37945225]
  • Jia Lai, Yueyue Li, Mei Ran, Qianqian Huang, Feihong Huang, Linjie Zhu, Yuesong Wu, Wenjun Zou, Xiang Xie, Yong Tang, Fei Yang, Anguo Wu, Guangbo Ge, Jianming Wu. Xanthotoxin, a novel inducer of platelet formation, promotes thrombocytopoiesis via IL-1R1 and MEK/ERK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Jul; 163(?):114811. doi: 10.1016/j.biopha.2023.114811. [PMID: 37156117]
  • Zhiming Yang, Tianxiang Xiao, Mengqing Deng, Wenxiu Wang, Haoxue Peng, Kai Lu. Nuclear receptors potentially regulate phytochemical detoxification in Spodoptera litura. Pesticide biochemistry and physiology. 2023 May; 192(?):105417. doi: 10.1016/j.pestbp.2023.105417. [PMID: 37105640]
  • César Sotelo-Leyva, Dante Avilés-Montes, Juan Manuel Rivas-González, Rodolfo Figueroa-Brito, Rodolfo Abarca-Vargas, Erubiel Toledo-Hernández, David Osvaldo Salinas-Sánchez. Xanthotoxin: an aphicidal coumarin from Ficus petiolaris against Melanaphis sacchari Zehntner (Hemiptera: Aphididae). Journal of food protection. 2023 Apr; ?(?):100084. doi: 10.1016/j.jfp.2023.100084. [PMID: 37019182]
  • Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh, Young-Won Chin. Alkaloids and Coumarins with Adiponectin-Secretion-Promoting Activities from the Leaves of Orixa japonica. Journal of natural products. 2023 01; 86(1):138-148. doi: 10.1021/acs.jnatprod.2c00844. [PMID: 36529937]
  • Jun-Fang Wu, Ablajan Turak, Deng Zang, Guo-An Zou, Haji Akber Aisa. Sesquiterpenoids from Seriphidium transiliense and Their Melanogenic Activity. Journal of natural products. 2022 11; 85(11):2570-2582. doi: 10.1021/acs.jnatprod.2c00527. [PMID: 36326734]
  • Anxin Wu, Jing Lu, Guofeng Zhong, Ling Lu, Yan Qu, Chen Zhang. Xanthotoxin (8-methoxypsoralen): A review of its chemistry, pharmacology, pharmacokinetics, and toxicity. Phytotherapy research : PTR. 2022 Oct; 36(10):3805-3832. doi: 10.1002/ptr.7577. [PMID: 35913174]
  • Noura S Dosoky, Prabodh Satyal, William N Setzer. Authentication of Citrus spp. Cold-Pressed Essential Oils by Their Oxygenated Heterocyclic Components. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196277. [PMID: 36234812]
  • Kriti Juneja, Till Beuerle, Debabrata Sircar. Enhanced Accumulation of Biologically Active Coumarin and Furanocoumarins in Callus Culture and Field-grown Plants of Ruta chalepensis Through LED Light-treatment. Photochemistry and photobiology. 2022 09; 98(5):1100-1109. doi: 10.1111/php.13610. [PMID: 35191044]
  • Huan Shi, Ya-Qing Chang, Xie Feng, Gui-Ya Yang, Yu-Guang Zheng, Qian Zheng, Lan-Lan Zhang, Dan Zhang, Long Guo. Chemical comparison and discrimination of two plant sources of Angelicae dahuricae Radix, Angelica dahurica and Angelica dahurica var. formosana, by HPLC-Q/TOF-MS and quantitative analysis of multiple components by a single marker. Phytochemical analysis : PCA. 2022 Jul; 33(5):776-791. doi: 10.1002/pca.3129. [PMID: 35470493]
  • Yu Shi, Shuo Sun, Yujun Zhang, Yingshi He, Minghong Du, Andrias O ÓReilly, Shuwen Wu, Yihua Yang, Yidong Wu. Single amino acid variations drive functional divergence of cytochrome P450s in Helicoverpa species. Insect biochemistry and molecular biology. 2022 07; 146(?):103796. doi: 10.1016/j.ibmb.2022.103796. [PMID: 35636594]
  • Shaohang Yuan, Zhiguang Yang, Changjiao Shang, Danyang Yang, Yuxuan Wang, Haifei Qi, Chaofan Sun, Lingling Wang, Xiuhua Zhao. A DFT study on the structure activity relationship of the natural xanthotoxin-based pharmaceutical cocrystals. Journal of molecular modeling. 2022 May; 28(6):155. doi: 10.1007/s00894-022-05152-5. [PMID: 35579707]
  • Oleg A Kulikov, Valentin P Ageev, Ekaterina P Brodovskaya, Vasilisa I Shlyapkina, Pavel S Petrov, Mikhail N Zharkov, Denis E Yakobson, Igor V Maev, Gleb B Sukhorukov, Nikolay A Pyataev. Evaluation of photocytotoxicity liposomal form of furanocoumarins Sosnowsky's hogweed. Chemico-biological interactions. 2022 Apr; 357(?):109880. doi: 10.1016/j.cbi.2022.109880. [PMID: 35271822]
  • Marwa Y Issa, Mohamed F Elshal, Noha Fathallah, Mostafa A Abdelkawy, Mokhtar Bishr, Osama Salama, Yasmin S Abulfadl. Potential Anticancer Activity of the Furanocoumarin Derivative Xanthotoxin Isolated from Ammi majus L. Fruits: In Vitro and In Silico Studies. Molecules (Basel, Switzerland). 2022 Jan; 27(3):. doi: 10.3390/molecules27030943. [PMID: 35164207]
  • Maria Magdalena Quetglas-Llabrés, Cristina Quispe, Jesús Herrera-Bravo, Marcelo D Catarino, Olívia R Pereira, Susana M Cardoso, Kamal Dua, Dinesh Kumar Chellappan, Kavita Pabreja, Saurabh Satija, Meenu Mehta, Antoni Sureda, Miquel Martorell, Dinara Satmbekova, Balakyz Yeskaliyeva, Javad Sharifi-Rad, Naeem Rasool, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu, Daniela Calina, William C Cho. Pharmacological Properties of Bergapten: Mechanistic and Therapeutic Aspects. Oxidative medicine and cellular longevity. 2022; 2022(?):8615242. doi: 10.1155/2022/8615242. [PMID: 35509838]
  • Kan Fu, Jianchun Zhang, Lanying Wang, Xu Zhao, Yanping Luo. Xanthotoxin induced photoactivated toxicity, oxidative stress and cellular apoptosis in Caenorhabditis elegans under ultraviolet A. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Jan; 251(?):109217. doi: 10.1016/j.cbpc.2021.109217. [PMID: 34673249]
  • Youdan Liang, Long Xie, Kai Liu, Yi Cao, Xiaolin Dai, Xian Wang, Jing Lu, Xumin Zhang, Xiaofang Li. Bergapten: A review of its pharmacology, pharmacokinetics, and toxicity. Phytotherapy research : PTR. 2021 Nov; 35(11):6131-6147. doi: 10.1002/ptr.7221. [PMID: 34347307]
  • Viola Hähnel, Andreas-Michael Brosig, Martin Ehrenschwender, Ralph Burkhardt, Robert Offner, Norbert Ahrens. Apoptosis induction by extracorporeal photopheresis is enhanced by increasing the 8-methoxypsoralen concentration and by replacing plasma with saline. Transfusion. 2021 10; 61(10):2991-2999. doi: 10.1111/trf.16634. [PMID: 34427336]
  • Laina Zarisa Mohd Kamal, Mowaffaq Adam Ahmed Adam, Siti Nurfatimah Mohd Shahpudin, Ahmad Naqeeb Shuib, Rosline Sandai, Norazian Mohd Hassan, Yasser Tabana, Dayang Fredalina Basri, Leslie Thian Lung Than, Doblin Sandai. Identification of Alkaloid Compounds Arborinine and Graveoline from Ruta angustifolia (L.) Pers for their Antifungal Potential against Isocitrate lyase (ICL1) gene of Candida albicans. Mycopathologia. 2021 May; 186(2):221-236. doi: 10.1007/s11046-020-00523-z. [PMID: 33550536]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Joanna Kowalczyk, Modestos Nakos-Bimpos, Alexia Polissidis, Christina Dalla, Nikolaos Kokras, Krystyna Skalicka-Wozniak, Barbara Budzynska. Xanthotoxin affects depression-related behavior and neurotransmitters content in a sex-dependent manner in mice. Behavioural brain research. 2021 02; 399(?):112985. doi: 10.1016/j.bbr.2020.112985. [PMID: 33144177]
  • Ewelina Kozioł, Krystyna Skalicka-Woźniak, Agnieszka Michalak, Katarzyna Kaszubska, Barbara Budzyńska. Xanthotoxin reverses Parkinson's disease-like symptoms in zebrafish larvae and mice models: a comparative study. Pharmacological reports : PR. 2021 Feb; 73(1):122-129. doi: 10.1007/s43440-020-00136-9. [PMID: 32700246]
  • Merhan O Hindam, Rabab H Sayed, Krystyna Skalicka-Woźniak, Barbara Budzyńska, Nesrine S El Sayed. Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin-induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO-1 signalling pathway modulation. Phytotherapy research : PTR. 2020 Sep; 34(9):2351-2365. doi: 10.1002/ptr.6686. [PMID: 32250498]
  • Viola Hähnel, Isabell Weber, Simon Tuemmler, Bernhard Graf, Michael Gruber, Ralph Burkhardt, Norbert Ahrens. Matrix-dependent absorption of 8-methoxypsoralen in extracorporeal photopheresis. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2020 Aug; 19(8):1099-1103. doi: 10.1039/c9pp00378a. [PMID: 32638713]
  • Muhanad Elhafiz, Guolin Zhao, Mohammed Ismail, Dengqiu Xu, Debanjan Das, Sisi Fan, Nong Cheng, Bashir A Yousef, Zhenzhou Jiang, Luyong Zhang. Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 06; 1865(6):158657. doi: 10.1016/j.bbalip.2020.158657. [PMID: 32045698]
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