Geniposidic acid (BioDeep_00000003789)

 

Secondary id: BioDeep_00000230078, BioDeep_00000398489

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


7-(hydroxymethyl)-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylic acid

化学式: C16H22O10 (374.1213)
中文名称: 京尼平苷酸
谱图信息: 最多检出来源 Viridiplantae(plant) 37.89%

分子结构信息

SMILES: C1=C(CO)[C@@H]2[C@H](C1)C(=CO[C@H]2O[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O)C(=O)O
InChI: InChI=1S/C16H22O10/c17-3-6-1-2-7-8(14(22)23)5-24-15(10(6)7)26-16-13(21)12(20)11(19)9(4-18)25-16/h1,5,7,9-13,15-21H,2-4H2,(H,22,23)

描述信息

Geniposidic acid is found in beverages. Geniposidic acid is a constituent of Genipa americana (genipap)
Constituent of Genipa americana (genipap). Geniposidic acid is found in beverages and fruits.
Geniposidic acid has radiation protection and anti-cancer activity.
Geniposidic acid has radiation protection and anti-cancer activity.

同义名列表

6 个代谢物同义名

7-(hydroxymethyl)-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4aH,5H,7aH-cyclopenta[c]pyran-4-carboxylic acid; 7-(Hydroxymethyl)-1-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-1H,4ah,5H,7ah-cyclopenta[c]pyran-4-carboxylate; Geniposidic acid; Geniposidate; NSC282171; Geniposidic acid



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

300 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKT1, MAPK14, MYD88, NFE2L2, NLRP3, RUNX2, TLR2, TLR4
Peripheral membrane protein 1 GORASP1
Endosome membrane 2 MYD88, TLR4
Endoplasmic reticulum membrane 1 CYP7A1
Nucleus 8 AKT1, FOS, MAPK14, MYD88, NFE2L2, NLRP3, NR1H4, RUNX2
cytosol 9 AKT1, FOS, GPT, GYPA, MAPK14, MYD88, NFE2L2, NLRP3, RUNX2
centrosome 1 NFE2L2
nucleoplasm 7 AKT1, FOS, GYPA, MAPK14, NFE2L2, NR1H4, RUNX2
RNA polymerase II transcription regulator complex 3 FOS, NFE2L2, NR1H4
Cell membrane 5 ABCB11, AKT1, GYPA, TLR4, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 AKT1
Multi-pass membrane protein 1 ABCB11
Golgi apparatus membrane 2 GORASP1, NLRP3
cell cortex 1 AKT1
cell surface 5 ABCB11, MYD88, TLR2, TLR4, TNF
glutamatergic synapse 2 AKT1, MAPK14
Golgi apparatus 3 GORASP1, NFE2L2, TLR2
Golgi membrane 4 ABCB11, GORASP1, INS, NLRP3
neuronal cell body 1 TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 2 NFE2L2, NLRP3
endosome 1 ABCB11
plasma membrane 8 ABCB11, AKT1, GYPA, MYD88, NFE2L2, TLR2, TLR4, TNF
Membrane 6 ABCB11, AKT1, GYPA, NLRP3, TLR2, TLR4
apical plasma membrane 1 ABCB11
axon 1 CCK
extracellular exosome 3 ABCB11, BMP3, GPT
endoplasmic reticulum 2 FOS, NLRP3
extracellular space 5 BMP3, CCK, IL6, INS, TNF
perinuclear region of cytoplasm 1 TLR4
intercellular canaliculus 1 ABCB11
mitochondrion 2 MAPK14, NLRP3
protein-containing complex 2 AKT1, MYD88
intracellular membrane-bounded organelle 1 CYP7A1
Microsome membrane 1 CYP7A1
Single-pass type I membrane protein 3 GYPA, TLR2, TLR4
Secreted 5 BMP3, CCK, IL6, INS, NLRP3
extracellular region 7 BMP3, CCK, IL6, INS, MAPK14, NLRP3, TNF
Single-pass membrane protein 2 CYP7A1, GYPA
transcription regulator complex 1 RUNX2
external side of plasma membrane 2 TLR4, TNF
microtubule cytoskeleton 1 AKT1
Early endosome 1 TLR4
cell-cell junction 1 AKT1
recycling endosome 2 ABCB11, TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Apical cell membrane 1 ABCB11
Membrane raft 2 TLR2, TNF
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 3 NR1H4, TLR2, TLR4
ciliary basal body 1 AKT1
chromatin 4 FOS, NFE2L2, NR1H4, RUNX2
mediator complex 1 NFE2L2
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 2 TLR4, TNF
phagocytic vesicle membrane 1 TLR2
[Isoform 3]: Nucleus 1 NR1H4
spindle pole 1 MAPK14
Recycling endosome membrane 1 ABCB11
Endomembrane system 1 NLRP3
endosome lumen 1 INS
microtubule organizing center 1 NLRP3
euchromatin 1 NR1H4
cell body 1 TLR2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
secretory granule membrane 1 TLR2
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
nuclear matrix 1 FOS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
[Isoform 2]: Nucleus 1 NR1H4
[Isoform 1]: Nucleus 1 NR1H4
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
protein-DNA complex 2 FOS, NFE2L2
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
extrinsic component of plasma membrane 1 MYD88
[Isoform 4]: Nucleus 1 NR1H4
intracellular canaliculus 1 ABCB11
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
ankyrin-1 complex 1 GYPA
interleukin-6 receptor complex 1 IL6
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Ruimin Tian, Xianfeng Liu, Yang Xiao, Lijia Jing, Honglin Tao, Lu Yang, Xianli Meng. Huang-Lian-Jie-Du decoction drug-containing serum inhibits IL-1β secretion from D-glucose and PA induced BV2 cells via autophagy/NLRP3 signaling. Journal of ethnopharmacology. 2024 Apr; 323(?):117686. doi: 10.1016/j.jep.2023.117686. [PMID: 38160864]
  • Chunbo Dong, Qiuyu Shao, Qingsong Ran, Xu Li, Yanfeng Han. Interactions of rhizosphere microbiota-environmental factors-pharmacological active ingredients of Eucommia ulmoides. Planta. 2024 Feb; 259(3):59. doi: 10.1007/s00425-024-04338-w. [PMID: 38311641]
  • Han Huang, Qi Gu, Si-Ming Nie, Jian-Dong Wang, Heng Zhao, Bo-Wen Zhai, Mao-Yu Zhang, Yu-Jie Fu. Untargeted metabolomics reveals the regulatory effect of geniposidic acid on lipid accumulation in HepG2 cells and Caenorhabditis elegans and validation in hyperlipidemic hamsters. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Dec; 125(?):155295. doi: 10.1016/j.phymed.2023.155295. [PMID: 38277945]
  • Ahmed Said Mohamed, Abdirahman Elmi, Rosella Spina, Maha A Y Kordofani, Dominique Laurain-Mattar, Hassan Nour, Oussama Abchir, Samir Chtita. In vitro and in silico analysis for elucidation of antioxidant potential of Djiboutian Avicennia Marina (Forsk.) Vierh. phytochemicals. Journal of biomolecular structure & dynamics. 2023 May; ?(?):1-16. doi: 10.1080/07391102.2023.2213338. [PMID: 37194334]
  • Sansei Nishibe, Hirotaka Oikawa, Kumiko Mitsui-Saitoh, Junichi Sakai, Wenping Zhang, Takahiko Fujikawa. The Differences of Mechanisms in Antihypertensive and Anti-Obesity Effects of Eucommia Leaf Extract between Rodents and Humans. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041964. [PMID: 36838952]
  • Hui Fu, Hui Zhu. Geniposidic acid protects lipopolysaccharide-induced acute lung injury via the TLR4/MyD88 signaling pathway in vitro and in vivo. Immunopharmacology and immunotoxicology. 2022 Dec; 44(6):984-992. doi: 10.1080/08923973.2022.2096465. [PMID: 35770920]
  • Zihan Li, Ping Yang, Shan Xue, Shijun Yuan, Lin Yuan, Renyi Yan, Ding Tang, Juan Li. Testosterone promotion effect of Eucommia ulmoides staminate flower via the steroidogenic pathway and potential hormonal mechanism. Scientific reports. 2022 11; 12(1):18765. doi: 10.1038/s41598-022-23578-y. [PMID: 36335171]
  • Lulu Ma, Ning Meng, Benyu Liu, Changjian Wang, Xin Chai, Shan Huang, Huijuan Yu, Yuefei Wang. Quantitative Analysis and Stability Study on Iridoid Glycosides from Seed Meal of Eucommia ulmoides Oliver. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185924. [PMID: 36144657]
  • Meijing Liu, Fujun Jin, Shuai Zhang, Shuang Li, Danqi Zhu, Yi Cui, Mingxiang Cai, Xiangning Liu, Yongbiao Zhang, Yao Sun, Changhui Liu, Xiaogang Wang. Activation of farnesoid X receptor signaling by geniposidic acid promotes osteogenesis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Aug; 103(?):154258. doi: 10.1016/j.phymed.2022.154258. [PMID: 35716540]
  • Jia-Shu Chen, Mu-Xuan Wang, Min-Min Wang, Yu-Kai Zhang, Xu Guo, Ying-Ying Chen, Meng-Qi Zhang, Jin-Yue Sun, Yu-Fa Liu, Chao Liu. Synthesis and biological evaluation of geniposide derivatives as inhibitors of hyperuricemia, inflammatory and fibrosis. European journal of medicinal chemistry. 2022 Jul; 237(?):114379. doi: 10.1016/j.ejmech.2022.114379. [PMID: 35468514]
  • Akira Ishimitsu, Akihiro Tojo, Hiroshi Satonaka, Toshihiko Ishimitsu. Eucommia ulmoides (Tochu) and its extract geniposidic acid reduced blood pressure and improved renal hemodynamics. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111901. doi: 10.1016/j.biopha.2021.111901. [PMID: 34328117]
  • Liang-Liang Ma, Lu-Lu Wang, Yue-Feng Zhang, Xiang-Fu Jiang, Xin-Liu Zhu, Ke Pan, Chuan-Xing Wan, Zhong-Bo Zhou. A new chlorine-containing iridoid glycoside from Plantago maxima. Natural product research. 2021 May; 35(9):1491-1496. doi: 10.1080/14786419.2019.1655410. [PMID: 31429297]
  • Lan Ji-Ping, Tong Ren-Chao, Sun Xiao-Meng, Zhang Hao-Yue, Sun Shuai, Xiong Ai-Zhen, Wang Zheng-Tao, Yang Li. Comparison of main chemical composition of Plantago asiatica L. and P. depressa Willd. seed extracts and their anti-obesity effects in high-fat diet-induced obese mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jan; 81(?):153362. doi: 10.1016/j.phymed.2020.153362. [PMID: 33296814]
  • Wenbin Qian, Juan Wang, Hanjing Ding, Wenjing Xie. Modeling of the static batch desorption and dynamic column elution of geniposidic acid from a porous anion-exchanger. Journal of chromatography. A. 2019 Jun; 1594(?):1-12. doi: 10.1016/j.chroma.2019.01.060. [PMID: 30772057]
  • Hao Chen, Jia Li, Lei Hu, Wei Zhao, Hao Yu, Han-Zhen Liu, Shi-Tang Ma. [Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Feb; 44(4):787-795. doi: 10.19540/j.cnki.cjcmm.20181204.013. [PMID: 30989893]
  • Hwa-Young Lee, Geum-Hwa Lee, Young Yoon, Han-Jung Chae. Rhus verniciflua and Eucommia ulmoides Protects Against High-Fat Diet-Induced Hepatic Steatosis by Enhancing Anti-Oxidation and AMPK Activation. The American journal of Chinese medicine. 2019; 47(6):1253-1270. doi: 10.1142/s0192415x19500642. [PMID: 31488034]
  • Dong Wu, Danmeng Yu, Yujia Zhang, Juane Dong, Dengwu Li, Dongmei Wang. Metabolite Profiles, Bioactivity, and HPLC Fingerprint of Different Varieties of Eucommia ulmoides Oliv.: Towards the Utilization of Medicinal and Commercial Chinese Endemic Tree. Molecules (Basel, Switzerland). 2018 Jul; 23(8):. doi: 10.3390/molecules23081898. [PMID: 30061494]
  • Xueyu Wang, Guo-Cai Wang, Jianhui Rong, Shi Wei Wang, Tzi Bun Ng, Yan Bo Zhang, Kai Fai Lee, Lin Zheng, Hei-Kiu Wong, Ken Kin Lam Yung, Stephen Cho Wing Sze. Identification of Steroidogenic Components Derived From Gardenia jasminoides Ellis Potentially Useful for Treating Postmenopausal Syndrome. Frontiers in pharmacology. 2018; 9(?):390. doi: 10.3389/fphar.2018.00390. [PMID: 29899696]
  • Rie Tanaka, Risa Inagaki, Naoki Sugimoto, Hiroshi Akiyama, Akito Nagatsu. Application of a quantitative 1H-NMR (1H-qNMR) method for the determination of geniposidic acid and acteoside in Plantaginis semen. Journal of natural medicines. 2017 Jan; 71(1):315-320. doi: 10.1007/s11418-016-1040-y. [PMID: 27631429]
  • Ling Liu, Ze-Bin Weng, Heng Wang, Xing-Yu Zhu, Zhi-Peng Chen, Li Wu, Wei-Dong Li. [Analysis on pharmacokinetics-pharmacodynamics correlation of effective ingredients of Qing'e wan]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Dec; 41(23):4436-4441. doi: 10.4268/cjcmm20162323. [PMID: 28933124]
  • Yongjun Li, Zipeng Gong, Xu Cao, Yonglin Wang, Aimin Wang, Lin Zheng, Yong Huang, Yanyu Lan. A UPLC-MS Method for Simultaneous Determination of Geniposidic Acid, Two Lignans and Phenolics in Rat Plasma and its Application to Pharmacokinetic Studies of Eucommia ulmoides Extract in Rats. European journal of drug metabolism and pharmacokinetics. 2016 Oct; 41(5):595-603. doi: 10.1007/s13318-015-0282-5. [PMID: 25990756]
  • Jing An, Fangdi Hu, Changhong Wang, Zijia Zhang, Li Yang, Zhengtao Wang. Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS. Xenobiotica; the fate of foreign compounds in biological systems. 2016 Sep; 46(9):793-804. doi: 10.3109/00498254.2015.1129470. [PMID: 27232980]
  • Hao Chen, Xiaotao Huang, Jianbin Min, Weirong Li, Rong Zhang, Wei Zhao, Changhui Liu, Lang Yi, Suiqing Mi, Ningsheng Wang, Qi Wang, Chenchen Zhu. Geniposidic acid protected against ANIT-induced hepatotoxity and acute intrahepatic cholestasis, due to Fxr-mediated regulation of Bsep and Mrp2. Journal of ethnopharmacology. 2016 Feb; 179(?):197-207. doi: 10.1016/j.jep.2015.12.033. [PMID: 26723467]
  • Bing Tian Zhao, Su Yang Jeong, Tae In Kim, Eun Kyoung Seo, Byung Sun Min, Jong Keun Son, Mi Hee Woo. Simultaneous quantitation and validation of method for the quality evaluation of Eucommiae cortex by HPLC/UV. Archives of pharmacal research. 2015 Dec; 38(12):2183-92. doi: 10.1007/s12272-015-0642-3. [PMID: 26216707]
  • Xing Liu, Xiao-jian Gong, Hua-guo Chen, Mei Zhou, Xin Zhou. [Study on quality standard of Eucommia ulmoides based on absorbed active components in rat plasma]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 May; 40(9):1771-5. doi: . [PMID: 26323146]
  • Nozomi Jimbo, Chinatsu Kawada, Yoshihiro Nomura. Herb extracts and collagen hydrolysate improve skin damage resulting from ultraviolet-induced aging in hairless mice. Bioscience, biotechnology, and biochemistry. 2015; 79(10):1624-8. doi: 10.1080/09168451.2015.1046362. [PMID: 26011399]
  • Eun Ju Lee, Jun Kee Hong, Wan Kyunn Whang. Simultaneous determination of bioactive marker compounds from Gardeniae fructus by high performance liquid chromatography. Archives of pharmacal research. 2014 Aug; 37(8):992-1000. doi: 10.1007/s12272-013-0293-1. [PMID: 24277694]
  • Lin Zhang, Yu-Liang Ma, Yang Liu, Yuan-Gang Zu. Development and validation of high liquid performance chromatography-tandem mass spectrometry method for simultaneous determination of geniposidic acid and aucubin in rat plasma for pharmacokinetic study after oral administration of Du-zhong tea extract. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jul; 963(?):62-9. doi: 10.1016/j.jchromb.2014.04.033. [PMID: 24929551]
  • Yan Huo, Yuxing Huang, Xiangmei Hou, Lifeng Han, Lei Wang, Erwei Liu, Xiumei Gao. Effects of fructus psoraleae extract on the intestinal absorption kinetics of geniposide and geniposidic acid in rat. Molecules (Basel, Switzerland). 2014 Jun; 19(6):7557-67. doi: 10.3390/molecules19067557. [PMID: 24914900]
  • Zhimin Long, Ruowen Zhang, Xu Zhao, Xia Meng, Kaishun Bi, Xiaohui Chen. Determination and pharmacokinetics of geniposidic acid in rat plasma after oral administration of Gardenia jasminoides fruit crude extract and Zhi-zi-chi decoction. Biomedical chromatography : BMC. 2013 Jun; 27(6):812-6. doi: 10.1002/bmc.2871. [PMID: 23420755]
  • Ying-Ju Lin, Chien-Chen Lai, Chih-Ho Lai, Shih-Che Sue, Cheng-Wen Lin, Chien-Hui Hung, Ting-Hsu Lin, Wei-Yi Hsu, Shao-Mei Huang, Yi-Lin Hung, Ni Tien, Xiang Liu, Chao-Ling Chen, Fuu-Jen Tsai. Inhibition of enterovirus 71 infections and viral IRES activity by Fructus gardeniae and geniposide. European journal of medicinal chemistry. 2013 Apr; 62(?):206-13. doi: 10.1016/j.ejmech.2012.12.038. [PMID: 23353754]
  • So-Jin Kim, Kang-Min Kim, Juhyun Park, Jong-Hwan Kwak, Yeong Shik Kim, Sun-Mee Lee. Geniposidic acid protects against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. Journal of ethnopharmacology. 2013 Mar; 146(1):271-7. doi: 10.1016/j.jep.2012.12.042. [PMID: 23298456]
  • Yuping Zhang, Mijun Peng, Liangliang Liu, Shuyun Shi, Sheng Peng. Screening, identification, and potential interaction of active compounds from Eucommia ulmodies leaves binding with bovine serum albumin. Journal of agricultural and food chemistry. 2012 Mar; 60(12):3119-25. doi: 10.1021/jf205135w. [PMID: 22385161]
  • Xia Zheng, Xiao-Tao Huang, Neng Li, Ying-Yi Li, Sui-Qing Mi, Ning-Sheng Wang, Chang-Hui Liu. Determination of geniposidic acid in rat plasma by LC-MS/MS and its application to in vivo pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Mar; 887-888(?):138-42. doi: 10.1016/j.jchromb.2012.01.013. [PMID: 22321407]
  • T Hirata, T Kobayashi, A Wada, T Ueda, T Fujikawa, H Miyashita, T Ikeda, S Tsukamoto, T Nohara. Anti-obesity compounds in green leaves of Eucommia ulmoides. Bioorganic & medicinal chemistry letters. 2011 Mar; 21(6):1786-91. doi: 10.1016/j.bmcl.2011.01.060. [PMID: 21324693]
  • Xin Jin, Jing Sun, Wenli Xie, Zongming Wan, Yuzhang Jin, Jiang Zhu. [Study of geniposide-acid on anti-inflammatory action for adjuvant-induced arthritis rats and mechanism of synoviocyte apoptosis in vitro]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Dec; 34(23):3082-6. doi: NULL. [PMID: 20222429]
  • Juane Dong, Xihan Ma. [Determination of geniposidic acid and chlorogenic acid in male flowers and related products of Eucommia ulmoides by reversed-phase high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2007 Mar; 25(2):217-20. doi: . [PMID: 17580690]
  • Hyoung Ja Kim, Eun Jung Kim, Seon Hee Seo, Cha-Gyun Shin, Changbae Jin, Yong Sup Lee. Vanillic acid glycoside and quinic acid derivatives from Gardeniae Fructus. Journal of natural products. 2006 Apr; 69(4):600-3. doi: 10.1021/np050447r. [PMID: 16643034]
  • Dong-Hyun Kim, Hyo-Jung Lee, Young-Jun Oh, Min-Jung Kim, Sung-Hoon Kim, Tae-Sook Jeong, Nam-In Baek. Iridoid glycosides isolated from Oldenlandia diffusa inhibit LDL-oxidation. Archives of pharmacal research. 2005 Oct; 28(10):1156-60. doi: 10.1007/bf02972979. [PMID: 16276972]
  • Mi-jun Peng, Chun-shan Zhou, Qi-fu Lei, Long-sheng Chen. [Study on technology of extracting geniposidic acid from Eucommia ulmiodes and its application]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2004 Mar; 29(3):229-31, 277. doi: ". [PMID: 15706846]
  • Jae Hyeok Lee, Chung Hwan Ku, Nam-In Baek, Sung-Hoon Kim, Hee Wook Park, Dae Keun Kim. Phytochemical constituents from Diodia teres. Archives of pharmacal research. 2004 Jan; 27(1):40-3. doi: 10.1007/bf02980043. [PMID: 14969336]
  • Yan Xu, Jin Cao, Yi-ming Wang, Guo-an Luo. [Simultaneous determination of 3 kinds of components in Gardenia by high-performance liquid chromatography under different UV-vis wave length]. Yao xue xue bao = Acta pharmaceutica Sinica. 2003 Jul; 38(7):543-6. doi: . [PMID: 14515803]
  • Kanyanga Cimanga, Nina Hermans, Sandra Apers, Sabine Van Miert, Hilde Van den Heuvel, Magda Claeys, Luc Pieters, Arnold Vlietinck. Complement-inhibiting iridoids from Morinda morindoides. Journal of natural products. 2003 Jan; 66(1):97-102. doi: 10.1021/np020215h. [PMID: 12542353]
  • T Deyama, S Nishibe, Y Nakazawa. Constituents and pharmacological effects of Eucommia and Siberian ginseng. Acta pharmacologica Sinica. 2001 Dec; 22(12):1057-70. doi: ". [PMID: 11749801]
  • J Suomi, S K Wiedmer, M Jussila, M L Riekkola. Determination of iridoid glycosides by micellar electrokinetic capillary chromatography-mass spectrometry with use of the partial filling technique. Electrophoresis. 2001 Aug; 22(12):2580-7. doi: 10.1002/1522-2683(200107)22:12<2580::aid-elps2580>3.0.co;2-7. [PMID: 11519962]
  • Z H Song, S H Mo, Y Chen, P F Tu, Y Y Zhao, J H Zheng. [Studies on chemical constituents of Cistanche tubulosa (Schenk) R. Wight]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2000 Dec; 25(12):728-30. doi: . [PMID: 12525059]
  • Y Li, K Metori, K Koike, Q M Che, S Takahashi. Improvement in the turnover rate of the stratum corneum in false aged model rats by the administration of geniposidic acid in Eucommia ulmoides Oliver Leaf. Biological & pharmaceutical bulletin. 1999 Jun; 22(6):582-5. doi: 10.1248/bpb.22.582. [PMID: 10408230]
  • G Wang, S Zhao, D Chen, Y Lu, Q Zheng. [Chemical constituents of fruits of Gardenia sootepensis Hutch]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1999 Jan; 24(1):38-40, 64. doi: ". [PMID: 12078152]
  • Y Li, T Sato, K Metori, K Koike, Q M Che, S Takahashi. The promoting effects of geniposidic acid and aucubin in Eucommia ulmoides Oliver leaves on collagen synthesis. Biological & pharmaceutical bulletin. 1998 Dec; 21(12):1306-10. doi: 10.1248/bpb.21.1306. [PMID: 9881644]
  • T Nakamura, Y Nakazawa, S Onizuka, S Satoh, A Chiba, K Sekihashi, A Miura, N Yasugahira, Y F Sasaki. Antimutagenicity of Tochu tea (an aqueous extract of Eucommia ulmoides leaves): 1. The clastogen-suppressing effects of Tochu tea in CHO cells and mice. Mutation research. 1997 Jan; 388(1):7-20. doi: 10.1016/s1383-5718(96)00096-4. [PMID: 9025787]
  • M Pennacchio, Y M Syah, E L Ghisalberti, E Alexander. Cardioactive compounds from Eremophila species. Journal of ethnopharmacology. 1996 Jul; 53(1):21-7. doi: 10.1016/0378-8741(96)01422-5. [PMID: 8807473]
  • S Ueda, Y Iwahashi, H Tokuda. Production of anti-tumor-promoting iridoid glucosides in Genipa americana and its cell cultures. Journal of natural products. 1991 Nov; 54(6):1677-80. doi: 10.1021/np50078a032. [PMID: 1667413]