Isokadsuranin (BioDeep_00000003697)

PANOMIX_OTCML-2023

代谢物信息卡片

(+)-gamma-Schizandrin

化学式: C23H28O6 (400.1885788)
中文名称: 异南五味子木脂宁, 五味子乙素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C1)C(C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC
InChI: InChI=1S/C23H28O6/c1-12-7-14-9-16(24-3)20(25-4)22(26-5)18(14)19-15(8-13(12)2)10-17-21(23(19)27-6)29-11-28-17/h9-10,12-13H,7-8,11H2,1-6H3

描述信息

D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.
Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

同义名列表

6 个代谢物同义名

(+)-gamma-Schizandrin; Deoxygomisin A; Isokadsuranin; schisandrin B; γ-Schisandrin; Wuweizisu B

数据库引用编号

14 个数据库交叉引用编号

ChEBI: CHEBI:4410
KEGG: C10555
PubChem: 108130
Metlin: METLIN68379
ChEMBL: CHEMBL479488
KNApSAcK: C00002596
KNApSAcK: C00007216
CAS: 82467-52-5
CAS: 61281-37-6
PMhub: MS000010992
PubChem: 12738
3DMET: B03953
NIKKAJI: J1.033.305I
medchemexpress: HY-N0089

分类词条

苯丙素类

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

82096 Eleutherococcus senticosus: 10.1080/14786419.2010.485304
50507 Schisandra chinensis:
13674 Schisandra sphenanthera:
124790 Schisandra propinqua: 10.1038/JA.2015.48
124791 Schisandra rubriflora: 10.1038/JA.2015.48
13673 Schisandra: 10.1093/NAR/GKP593
133442 Schisandra bicolor: 10.1021/NP100067W
82096 Eleutherococcus senticosus: 10.1080/14786419.2010.485304
50507 Schisandra chinensis:
13674 Schisandra sphenanthera:
124790 Schisandra propinqua: 10.1038/JA.2015.48
124791 Schisandra rubriflora: 10.1038/JA.2015.48
13673 Schisandra: 10.1093/NAR/GKP593
133442 Schisandra bicolor: 10.1021/NP100067W
50507 Schisandra chinensis: -
33090 Plants: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Miao Zhao, Jun Wu, Yuchen Jin, Min Li, KeXin Yu, Haibo Yu. Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels. Journal of ethnopharmacology. 2024 May; 326(?):117996. doi: 10.1016/j.jep.2024.117996. [PMID: 38431110]
Michal Rybnikář, Milan Malaník, Karel Šmejkal, Emil Švajdlenka, Polina Shpet, Pavel Babica, Stefano Dall'Acqua, Ondřej Smištík, Ondřej Jurček, Jakub Treml. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063465. [PMID: 38542438]
Fei Hu, WenJie Hu, Hongming Xu. Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells. The Journal of membrane biology. 2024 Jan; ?(?):. doi: 10.1007/s00232-023-00299-5. [PMID: 38285126]
Feng-Rui Li, Yang Yu, Yu-Meng Du, Liang Kong, Yang Liu, Jia-Hua Wang, Mu-Han Chen, Mo Liu, Zi-Xu Zhang, Xue-Tao Li, Rui-Jun Ju. Borneol-Modified Schisandrin B Micelles Cross the Blood-Brain Barrier To Treat Alzheimer's Disease in Aged Mice. ACS chemical neuroscience. 2024 Jan; ?(?):. doi: 10.1021/acschemneuro.3c00625. [PMID: 38214579]
Jia Shang, Wenhui Yan, Xin Cui, Weina Ma, Zhuanzhuan Wang, Na Liu, Xinyao Yi, Tingli Guo, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Wei Cui, Lina Chen. Schisandrin B, a potential GLP-1R agonist, exerts anti-diabetic effects by stimulating insulin secretion. Molecular and cellular endocrinology. 2023 Jul; 577(?):112029. doi: 10.1016/j.mce.2023.112029. [PMID: 37495090]
Ho Yin Pekkle Lam, Ting-Ruei Liang, Shih-Yi Peng. Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B. Nutrients. 2023 Apr; 15(8):. doi: 10.3390/nu15081909. [PMID: 37111128]
Caitao Dong, Chao Song, Ziqi He, Qianlin Song, Tianbao Song, Junwei Liu, Yunhe Xiong, Xiaozhe Su, Jiawei Zhou, Sixing Yang, Wenbiao Liao. Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro. International immunopharmacology. 2023 Apr; 117(?):110042. doi: 10.1016/j.intimp.2023.110042. [PMID: 36940552]
Chuang Li, Hyun Ju Oh, Haixing Liu, Min Kyu Kim. Schisandrin B protects boar spermatozoa against oxidative damage and increases their fertilization ability during in vitro storage. Theriogenology. 2023 Mar; 198(?):194-201. doi: 10.1016/j.theriogenology.2022.12.041. [PMID: 36592517]
Xiankuan Li, Ying Zhao, Sihan Gong, Tianbao Song, Jiaming Ge, Jiarong Li, Jian Zhang, Kun Fu, Yanchao Zheng, Lin Ma. Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy. Bioorganic chemistry. 2023 01; 130(?):106272. doi: 10.1016/j.bioorg.2022.106272. [PMID: 36403334]
Zhihua Zhang, Hongmin Guo, Zihui Hu, Congfa Zhou, Qixing Hu, Hao Peng, Gan Tang, Zehao Xiao, Lingzhi Pi, Guilin Li. Schisandrin B Alleviates Diabetic Cardiac Autonomic neuropathy Induced by P2X7 Receptor in Superior Cervical Ganglion via NLRP3. Disease markers. 2023; 2023(?):9956950. doi: 10.1155/2023/9956950. [PMID: 36660202]
Yiwen Zhang, Saiyu Li, Panpan Yang, Qian Zhang, Huarong Xu, Kaishun Bi, Qing Li. A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154273. doi: 10.1016/j.phymed.2022.154273. [PMID: 36044818]
Wu Luo, Ke Lin, Junyi Hua, Jibo Han, Qiuyan Zhang, Lingfeng Chen, Zia A Khan, Gaojun Wu, Yi Wang, Guang Liang. Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 11; 9(31):e2202590. doi: 10.1002/advs.202202590. [PMID: 36180407]
Li-Shan Yan, Shuo-Feng Zhang, Gan Luo, Brian Chi-Yan Cheng, Chao Zhang, Yi-Wei Wang, Xin-Yu Qiu, Xiao-Hong Zhou, Qing-Gao Wang, Xue-Lan Song, Si-Yuan Pan, Yi Zhang. Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway. Metabolism: clinical and experimental. 2022 06; 131(?):155200. doi: 10.1016/j.metabol.2022.155200. [PMID: 35405150]
Ruojia Ma, Yike Zhan, Yamei Zhang, Liangan Wu, Xing Wang, Ming Guo. Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice. Drug development research. 2022 05; 83(3):735-744. doi: 10.1002/ddr.21905. [PMID: 34927282]
Hongwei Shi, Yue Yan, Hong Yang, Peng Pu, Heng Tang. Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity. BioMed research international. 2022; 2022(?):5623555. doi: 10.1155/2022/5623555. [PMID: 36060128]
Xiufeng Chen, Zhen Xiao, Zhiyan Jiang, Yonghong Jiang, Wen Li, Mingjing Wang. Schisandrin B Attenuates Airway Inflammation and Airway Remodeling in Asthma by Inhibiting NLRP3 Inflammasome Activation and Reducing Pyroptosis. Inflammation. 2021 Dec; 44(6):2217-2231. doi: 10.1007/s10753-021-01494-z. [PMID: 34143347]
Jufeng Guo, Yingying Shen, Xia Lin, Honggang Chen, Jian Liu. Schisandrin B promotes TH1 cell differentiation by targeting STAT1. International immunopharmacology. 2021 Dec; 101(Pt A):108213. doi: 10.1016/j.intimp.2021.108213. [PMID: 34624651]
Zhiman Li, Lijuan Zhao, Yunshi Xia, Jianbo Chen, Mei Hua, Yinshi Sun. Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226882. [PMID: 34833975]
Lu Zhang, Liang Kong, Si-Yu He, Xin-Ze Liu, Yang Liu, Juan Zang, Rui-Jun Ju, Xue-Tao Li. The anti-ovarian cancer effect of RPV modified paclitaxel plus schisandra B liposomes in SK-OV-3 cells and tumor-bearing mice. Life sciences. 2021 Nov; 285(?):120013. doi: 10.1016/j.lfs.2021.120013. [PMID: 34614418]
Ee Taek Hwang, Ye Eun Joo, Ka Ram Kim, Jinhee Jeong. Biomineralized separation, concentration, and evaluation of the effectiveness of Schisandra chinensis fruit extract. Food chemistry. 2021 Oct; 360(?):130063. doi: 10.1016/j.foodchem.2021.130063. [PMID: 34029927]
Fu-Yi Cai, Xue-Min Yao, Ming Jing, Liang Kong, Jing-Jing Liu, Min Fu, Xin-Ze Liu, Lu Zhang, Si-Yu He, Xue-Tao Li, Rui-Jun Ju. Enhanced antitumour efficacy of functionalized doxorubicin plus schisandrin B co-delivery liposomes via inhibiting epithelial-mesenchymal transition. Journal of liposome research. 2021 Jun; 31(2):113-129. doi: 10.1080/08982104.2020.1745831. [PMID: 32200703]
Tzu-Yi Chiang, Hong-Jaan Wang, Yen-Cih Wang, Elise Chia-Hui Tan, I-Jung Lee, Chul-Ho Yun, Yune-Fang Ueng. Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats. Journal of ethnopharmacology. 2021 May; 271(?):113914. doi: 10.1016/j.jep.2021.113914. [PMID: 33571617]
Zeyu Ma, Gang Xu, Yingying Shen, Shufang Hu, Xia Lin, Jun Zhou, Wei Zhao, Jian Liu, Jiaoli Wang, Jufeng Guo. Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation. Pharmacological research. 2021 04; 166(?):105459. doi: 10.1016/j.phrs.2021.105459. [PMID: 33545313]
Yaqin Chen, Yu Kong, Qili Wang, Jian Chen, Hua Chen, Huihui Xie, Lan Li. Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma. Journal of immunology research. 2021; 2021(?):8029963. doi: 10.1155/2021/8029963. [PMID: 34258300]
Xiu-Ying Li, Luan-Xia Shi, Xue-Min Yao, Ming Jing, Qin-Qing Li, Ying-Li Wang, Qing-Shan Li. Functional vinorelbine plus schisandrin B liposomes destroying tumor metastasis in treatment of gastric cancer. Drug development and industrial pharmacy. 2021 Jan; 47(1):100-112. doi: 10.1080/03639045.2020.1862169. [PMID: 33295825]
Yan Fei, Shi Jiang-Pei, Chen Hai-Zhen, Shen Jun-Yi, Xie Xing-Mei, Jiang Zi-Fei, G U Xiao-Yan, Liu Ying, Feng Nian-Ping. [Preparation and evaluation of schisandrin B-loaded F127 modified lipid-polymer nanoparticles for inhibition of breast cancer lung metastasis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Nov; 45(21):5177-5183. doi: 10.19540/j.cnki.cjcmm.20200819.305. [PMID: 33350233]
Joo Young Lee, Ji Hye Lee, Chong Kun Cheon. Functional Characterization of Gomisin N in High-Fat-Induced Drosophila Obesity Models. International journal of molecular sciences. 2020 Sep; 21(19):. doi: 10.3390/ijms21197209. [PMID: 33003580]
Su-Jin Ahn, Hyung Joo Kim, Ayoung Lee, Seung-Sik Min, Sangwhan In, Eunmi Kim. Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2020 Sep; 37(9):1437-1448. doi: 10.1080/19440049.2020.1778187. [PMID: 32530783]
Ming Jing, Xiao-Jie Bi, Xue-Min Yao, Fuyi Cai, Jing-Jing Liu, Min Fu, Liang Kong, Xin-Ze Liu, Lu Zhang, Si-Yu He, Lian-Qun Jia, Xue-Tao Li. Enhanced antitumor efficacy using epirubicin and schisandrin B co-delivery liposomes modified with PFV via inhibiting tumor metastasis. Drug development and industrial pharmacy. 2020 Apr; 46(4):621-634. doi: 10.1080/03639045.2020.1742145. [PMID: 32162988]
Kippeum Lee, Yeon-Joo Lee, Kui-Jin Kim, Sungwoo Chei, Heegu Jin, Hyun-Ji Oh, Boo-Yong Lee. Gomisin N from Schisandra chinensis Ameliorates Lipid Accumulation and Induces a Brown Fat-Like Phenotype through AMP-Activated Protein Kinase in 3T3-L1 Adipocytes. International journal of molecular sciences. 2020 Mar; 21(6):. doi: 10.3390/ijms21062153. [PMID: 32245100]
M I Nasser, Shuoji Zhu, Chen Chen, Mingyi Zhao, Huanlei Huang, Ping Zhu. A Comprehensive Review on Schisandrin B and Its Biological Properties. Oxidative medicine and cellular longevity. 2020; 2020(?):2172740. doi: 10.1155/2020/2172740. [PMID: 32256947]
Guangxu Cao, Shuang Li, Hezhan Shi, Peidi Yin, Jialing Chen, Huifeng Li, Ying Zhong, Li-Ting Diao, Bin Du. Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT. Toxicology and applied pharmacology. 2019 12; 385(?):114769. doi: 10.1016/j.taap.2019.114769. [PMID: 31697999]
Hai Zhang, Qingshan Chen, Arik Dahan, Jiyang Xue, Liwen Wei, Weifeng Tan, Guoqing Zhang. Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl4-induced liver fibrosis in rats by RNA-sequencing. Chemico-biological interactions. 2019 Aug; 309(?):108675. doi: 10.1016/j.cbi.2019.05.041. [PMID: 31150632]
Yiwen Zhang, Xinyan Lv, Ran Liu, Mingyang Zhang, Haopeng Liu, Hao Gao, Qian Zhang, Huarong Xu, Qing Li, Kaishun Bi. An integrated strategy for ascertaining quality marker of Schisandra chinensis (Turcz.) Baill based on correlation analysis between depression-related monoaminergic metabolites and chemical components profiling. Journal of chromatography. A. 2019 Aug; 1598(?):122-131. doi: 10.1016/j.chroma.2019.03.056. [PMID: 31047662]
Bingsheng Yu, Dongdi Sheng, Qiumin Tan. Determination of Schisandrin A and Schisandrin B in Traditional Chinese Medicine Preparation Huganpian Tablet by RP-HPLC. Chemical & pharmaceutical bulletin. 2019 Jul; 67(7):713-716. doi: 10.1248/cpb.c18-00968. [PMID: 31006725]
Jian-Hua Qin, Jia-Ru Lin, Wen-Fei Ding, Wei-Hua Wu. Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway. Inflammation. 2019 Jun; 42(3):884-894. doi: 10.1007/s10753-018-0943-z. [PMID: 30519926]
Zhi-Rong Ji, Wei-Liang Xue, Ling Zhang. Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4. Inflammation. 2019 Apr; 42(2):731-739. doi: 10.1007/s10753-018-0931-3. [PMID: 30506107]
Xiao-Long Hu, Cui Guo, Ji-Qin Hou, Jia-Hao Feng, Xiao-Qi Zhang, Fei Xiong, Wen-Cai Ye, Hao Wang. Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3β Inhibitors with Neuroprotective Effects against Alzheimer's Disease: Stereochemistry and Biological Activity. ACS chemical neuroscience. 2019 02; 10(2):996-1007. doi: 10.1021/acschemneuro.8b00252. [PMID: 29944335]
Maarit Kortesoja, Elina Karhu, Elin Soffia Olafsdottir, Jona Freysdottir, Leena Hanski. Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells. Free radical biology & medicine. 2019 02; 131(?):309-317. doi: 10.1016/j.freeradbiomed.2018.12.019. [PMID: 30578916]
Zhenxin Mou, Zhiguo Feng, Zheng Xu, Fei Zhuang, Xuyong Zheng, Xiaokun Li, Jianchang Qian, Guang Liang. Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress. Biochemical and biophysical research communications. 2019 01; 508(1):243-249. doi: 10.1016/j.bbrc.2018.11.128. [PMID: 30477745]
Hong-Jaan Wang, Chung-Kuang Lu, Wei-Ching Chen, An-Chi Chen, Yune-Fang Ueng. Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation. Journal of food and drug analysis. 2019 01; 27(1):284-294. doi: 10.1016/j.jfda.2018.10.005. [PMID: 30648582]
Ming Ding, Peng Shu, Shuang Gao, Fenglou Wang, Yitian Gao, Yu Chen, Wenjuan Deng, Gaiying He, Zhenlin Hu, Tianduo Li. Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway. International journal of molecular medicine. 2018 Dec; 42(6):3571-3581. doi: 10.3892/ijmm.2018.3901. [PMID: 30272282]
Jia-Wei Wang, Feng-Yin Liang, Xiang-Shuo Ouyang, Pei-Bo Li, Zhong Pei, Wei-Wei Su. Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling. Chinese journal of natural medicines. 2018 Dec; 16(12):916-925. doi: 10.1016/s1875-5364(18)30133-x. [PMID: 30595216]
Xiaodong Ma, Mengqi Hu, Hao Wang, Jiaming Li. Discovery of traditional Chinese medicine monomers and their synthetic intermediates, analogs or derivatives for battling P-gp-mediated multi-drug resistance. European journal of medicinal chemistry. 2018 Nov; 159(?):381-392. doi: 10.1016/j.ejmech.2018.09.061. [PMID: 30308411]
Dawei Li, Aijing Leng, Yan Qi, Ruichen Wang, Lianhong Yin, Xu Han, Chengpeng Sun, Xingjie Guo, Linlin Fang, Jinyong Peng. Simultaneous quantification of Schisandrin B enantiomers in rat plasma by chiral LC-MS/MS: Application in a stereoselective pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2018 Sep; 159(?):186-191. doi: 10.1016/j.jpba.2018.06.056. [PMID: 29990885]
Arulkumar Nagappan, Dae Young Jung, Ji-Hyun Kim, Hoyoung Lee, Myeong Ho Jung. Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092601. [PMID: 30200508]
Qiang Liu, Jinxin Song, Hong Li, Lei Dong, Shejiao Dai. Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin. International journal of molecular medicine. 2018 Apr; 41(4):2108-2116. doi: 10.3892/ijmm.2018.3409. [PMID: 29393335]
Xuyong Zhao, Yijia Xiang, Changhong Cai, Aiming Zhou, Ning Zhu, Chunlai Zeng. Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats. Molecular medicine reports. 2018 Jan; 17(1):556-561. doi: 10.3892/mmr.2017.7926. [PMID: 29115607]
Dae Young Jung, Ji-Hyun Kim, Hoyoung Lee, Myeong Ho Jung. Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase. Biochemical and biophysical research communications. 2017 12; 494(3-4):587-593. doi: 10.1016/j.bbrc.2017.10.120. [PMID: 29079190]
James T Lyles, Paula Tyler, E Jane Bradbury, Kate Nelson, Carl F Brown, Stefanie T Pierce, Cassandra L Quave. Comparative Phytochemical Analysis of Chinese and Bay Starvine (Schisandra spp.): Potential for Development as a New Dietary Supplement Ingredient. Journal of dietary supplements. 2017 Nov; 14(6):640-652. doi: 10.1080/19390211.2017.1304483. [PMID: 28384001]
Qiao Lai, Zhengzhong Luo, Chunying Wu, Sisi Lai, Hanmei Wei, Tongming Li, Qing Wang, Yang Yu. Attenuation of cyclosporine A induced nephrotoxicity by schisandrin B through suppression of oxidative stress, apoptosis and autophagy. International immunopharmacology. 2017 Nov; 52(?):15-23. doi: 10.1016/j.intimp.2017.08.019. [PMID: 28846887]
Sook-Jin Kim, Hwajin Shin, Seong-Moon Cheon, Se-Mi Ko, Seong-Ho Ham, Young-Dal Kwon, Yong-Bok Lee, Hea-Young Cho. A sensitive UHPLC-MS/MS method for the simultaneous quantification of three lignans in human plasma and its application to a pharmacokinetic study. Journal of separation science. 2017 Sep; 40(17):3430-3439. doi: 10.1002/jssc.201700588. [PMID: 28675628]
Hiu Yee Kwan, Jiahui Wu, Tao Su, Xiao-Juan Chao, Hua Yu, Bin Liu, Xiuqiong Fu, Anfernee Kai Wing Tse, Chi Leung Chan, Wang Fun Fong, Zhi-Ling Yu. Schisandrin B regulates lipid metabolism in subcutaneous adipocytes. Scientific reports. 2017 08; 7(1):10266. doi: 10.1038/s41598-017-10385-z. [PMID: 28860616]
Minyu Zhang, Hongwei Wu, Feifei Guo, Yangyang Yu, Junying Wei, Ya Geng, Shifeng Wang, Shiyou Li, Hongjun Yang. Identification of active components in Yixinshu Capsule with protective effects against myocardial dysfunction on human induced pluripotent stem cell-derived cardiomyocytes by an integrative approach. Molecular bioSystems. 2017 Jul; 13(8):1469-1480. doi: 10.1039/c6mb00813e. [PMID: 28604846]
JungNo Lee, Hwa Sun Ryu, Jae-Moon Kim, Tae-Hwa Jung, Sung-Min Park, Yong-Moon Lee. Anti-melanogenic effect of gomisin N from Schisandra chinensis (Turcz.) Baillon (Schisandraceae) in melanoma cells. Archives of pharmacal research. 2017 Jul; 40(7):807-817. doi: 10.1007/s12272-017-0903-4. [PMID: 28695326]
D Q Xin, Z M Hu, H J Huo, X J Yang, D Han, W H Xing, Y Zhao, Q H Qiu. Schisandrin B attenuates the inflammatory response, oxidative stress and apoptosis induced by traumatic spinal cord injury via inhibition of p53 signaling in adult rats. Molecular medicine reports. 2017 Jul; 16(1):533-538. doi: 10.3892/mmr.2017.6622. [PMID: 28560444]
So-Hye Hong, Mei Li, Eui-Bae Jeung, Geun-Shik Lee, Eui-Ju Hong, Young-Whan Choi, Beum-Soo An. Therapeutic effects of Schisandra chinensis on the hyperprolactinemia in rat. International journal of oncology. 2017 Apr; 50(4):1448-1454. doi: 10.3892/ijo.2017.3881. [PMID: 28259983]
Jianjun Wu, Jing Jia, Li Liu, Fan Yang, Yuhua Fan, Sen Zhang, Dongxia Yan, Rui Bu, Guangnan Li, Yanhui Gao, Yanjun Chen. Schisandrin B displays a protective role against primary pulmonary hypertension by targeting transforming growth factor β1. Journal of the American Society of Hypertension : JASH. 2017 03; 11(3):148-157.e1. doi: 10.1016/j.jash.2016.12.007. [PMID: 28117274]
Ye-Rang Yun, Ji-Hyun Kim, Ji Ha Kim, Myeong Ho Jung. Protective effects of gomisin N against hepatic steatosis through AMPK activation. Biochemical and biophysical research communications. 2017 Jan; 482(4):1095-1101. doi: 10.1016/j.bbrc.2016.11.164. [PMID: 27914812]
Yi Zhang, Jing Zhao, Shu-Feng Zhou, Zhi-Ling Yu, Xiao-Yan Wang, Pei-Li Zhu, Zhu-Sheng Chu, Si-Yuan Pan, Ming Xie, Kam-Ming Ko. Biochemical mechanism underlying hypertriglyceridemia and hepatic steatosis/hepatomegaly induced by acute schisandrin B treatment in mice. Lipids in health and disease. 2017 Jan; 16(1):8. doi: 10.1186/s12944-017-0406-9. [PMID: 28086886]
Chenguang Gao, Hong Chen, Cong Niu, Jie Hu, Bo Cao. Protective effect of Schizandrin B against damage of UVB irradiated skin cells depend on inhibition of inflammatory pathways. Bioengineered. 2017 Jan; 8(1):36-44. doi: 10.1080/21655979.2016.1227572. [PMID: 27689692]
Ning Zhu, Changhong Cai, Aiming Zhou, Xuyong Zhao, Yijia Xiang, Chunlai Zeng. Schisandrin B Prevents Hind Limb from Ischemia-Reperfusion-Induced Oxidative Stress and Inflammation via MAPK/NF-κB Pathways in Rats. BioMed research international. 2017; 2017(?):4237973. doi: 10.1155/2017/4237973. [PMID: 28706944]
Mingfeng Shao, Wenfang Yang, Guangying Han. Protective effects on myocardial infarction model: delivery of schisandrin B using matrix metalloproteinase-sensitive peptide-modified, PEGylated lipid nanoparticles. International journal of nanomedicine. 2017; 12(?):7121-7130. doi: 10.2147/ijn.s141549. [PMID: 29026305]
Lian-lin Su, Xue Cheng, De Ji, Li-jun Wang, Xi-yan Ding, Tu-lin Lu, Chun-qin Mao, Ji Zhang. [Analysis of lignans and their metabolites derived from Schisandra chinensis and vinegar Schisandra chinensis in rats’ plasma, bile, urine and faeces based on UHPLC-QTOF/MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 10; 51(10):1600-8. doi: . [PMID: 29932608]
Ryota Araki, Yosuke Hiraki, Shoji Nishida, Yuka Inatomi, Takeshi Yabe. Gomisin N ameliorates lipopolysaccharide-induced depressive-like behaviors by attenuating inflammation in the hypothalamic paraventricular nucleus and central nucleus of the amygdala in mice. Journal of pharmacological sciences. 2016 Oct; 132(2):138-144. doi: 10.1016/j.jphs.2016.09.004. [PMID: 27733273]
Zhiying Gao, Jishun Zhang, Libo Li, Longqing Shen, Qingyi Li, Yu Zou, Xiaohui Du, Zhibo Zhao. Heat shock proteins 27 and 70 contribute to the protection of Schisandrin B against d-galactosamine-induced liver injury in mice. Canadian journal of physiology and pharmacology. 2016 Apr; 94(4):373-8. doi: 10.1139/cjpp-2015-0419. [PMID: 26666831]
Pou Kuan Leong, Kam Ming Ko. Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease. Oxidative medicine and cellular longevity. 2016; 2016(?):6171658. doi: 10.1155/2016/6171658. [PMID: 27847552]
Liyun Zhang, Lue Xiang, Yiwen Liu, Prahatha Venkatraman, Leelyn Chong, Jin Cho, Sylvia Bonilla, Zi-Bing Jin, Chi Pui Pang, Kam Ming Ko, Ping Ma, Mingzhi Zhang, Yuk Fai Leung. A Naturally-Derived Compound Schisandrin B Enhanced Light Sensation in the pde6c Zebrafish Model of Retinal Degeneration. PloS one. 2016; 11(3):e0149663. doi: 10.1371/journal.pone.0149663. [PMID: 26930483]
Pou Kuan Leong, Kam Ming Ko. Schisandrin B induces an Nrf2-mediated thioredoxin expression and suppresses the activation of inflammasome in vitro and in vivo. BioFactors (Oxford, England). 2015 Sep; 41(5):314-23. doi: 10.1002/biof.1224. [PMID: 26307448]
Tao Yang, Shan Liu, Tian-Hui Zheng, Yan-Yan Tao, Cheng-Hai Liu. Comparative pharmacokinetics and tissue distribution profiles of lignan components in normal and hepatic fibrosis rats after oral administration of Fuzheng Huayu recipe. Journal of ethnopharmacology. 2015 May; 166(?):305-12. doi: 10.1016/j.jep.2015.03.024. [PMID: 25794805]
Yiming Jiang, Xiaomei Fan, Ying Wang, Huasen Tan, Pan Chen, Hang Zeng, Min Huang, Huichang Bi. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chemico-biological interactions. 2015 Apr; 231(?):83-9. doi: 10.1016/j.cbi.2015.02.022. [PMID: 25753323]
Lijia Xu, Nicole Grandi, Claudia Del Vecchio, Daniela Mandas, Angela Corona, Dario Piano, Francesca Esposito, Cristina Parolin, Enzo Tramontano. From the traditional Chinese medicine plant Schisandra chinensis new scaffolds effective on HIV-1 reverse transcriptase resistant to non-nucleoside inhibitors. Journal of microbiology (Seoul, Korea). 2015 Apr; 53(4):288-93. doi: 10.1007/s12275-015-4652-0. [PMID: 25740376]
Hiu Yee Kwan, Xuyan Niu, Wenlin Dai, Tiejun Tong, Xiaojuan Chao, Tao Su, Chi Leung Chan, Kim Chung Lee, Xiuqiong Fu, Hua Yi, Hua Yu, Ting Li, Anfernee Kai Wing Tse, Wang Fun Fong, Si-Yuan Pan, Aiping Lu, Zhi-Ling Yu. Lipidomic-based investigation into the regulatory effect of Schisandrin B on palmitic acid level in non-alcoholic steatotic livers. Scientific reports. 2015 Mar; 5(?):9114. doi: 10.1038/srep09114. [PMID: 25766252]
Rajarajan A Thandavarayan, Vijayasree V Giridharan, Somasundaram Arumugam, Kenji Suzuki, Kam Ming Ko, Prasanna Krishnamurthy, Kenichi Watanabe, Tetsuya Konishi. Schisandrin B prevents doxorubicin induced cardiac dysfunction by modulation of DNA damage, oxidative stress and inflammation through inhibition of MAPK/p53 signaling. PloS one. 2015; 10(3):e0119214. doi: 10.1371/journal.pone.0119214. [PMID: 25742619]
Vijayasree V Giridharan, Rajarajan A Thandavarayan, Somasundaram Arumugam, Makoto Mizuno, Hiroyuki Nawa, Kenji Suzuki, Kam M Ko, Prasanna Krishnamurthy, Kenichi Watanabe, Tetsuya Konishi. Schisandrin B Ameliorates ICV-Infused Amyloid β Induced Oxidative Stress and Neuronal Dysfunction through Inhibiting RAGE/NF-κB/MAPK and Up-Regulating HSP/Beclin Expression. PloS one. 2015; 10(11):e0142483. doi: 10.1371/journal.pone.0142483. [PMID: 26556721]
Wei Hou, Wei Gao, Datao Wang, Qingxiu Liu, Siwen Zheng, Yingping Wang. The Protecting Effect of Deoxyschisandrin and Schisandrin B on HaCaT Cells against UVB-Induced Damage. PloS one. 2015; 10(5):e0127177. doi: 10.1371/journal.pone.0127177. [PMID: 25978330]
Cheng-Xian Guo, Sheng Deng, Ji-Ye Yin, Zhao-Qian Liu, Wei Zhang, Hong-Hao Zhou. Schisandrin A and B induce organic anion transporting polypeptide 1B1 transporter activity. Die Pharmazie. 2015 Jan; 70(1):29-32. doi: . [PMID: 25975095]
Valérian Bunel, Marie-Hélène Antoine, Joëlle Nortier, Pierre Duez, Caroline Stévigny. Protective effects of schizandrin and schizandrin B towards cisplatin nephrotoxicity in vitro. Journal of applied toxicology : JAT. 2014 Dec; 34(12):1311-9. doi: 10.1002/jat.2951. [PMID: 24155209]
Ou Wang, Qian Cheng, Jia Liu, Yong Wang, Liang Zhao, Feng Zhou, Baoping Ji. Hepatoprotective effect of Schisandra chinensis (Turcz.) Baill. lignans and its formula with Rubus idaeus on chronic alcohol-induced liver injury in mice. Food & function. 2014 Nov; 5(11):3018-25. doi: 10.1039/c4fo00550c. [PMID: 25255087]
Li-shi Zheng, Shu-shan Du, Qian Cai. [Study on chemical constituents from Schisandra chinensis stem]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2014 Oct; 37(10):1803-6. doi: . [PMID: 25895389]
Yuan Xie, Haiping Hao, Hong Wang, Cen Guo, An Kang, Guangji Wang. Reversing effects of lignans on CCl4-induced hepatic CYP450 down regulation by attenuating oxidative stress. Journal of ethnopharmacology. 2014 Aug; 155(1):213-21. doi: 10.1016/j.jep.2014.05.016. [PMID: 24910408]
Xiaoyan Wu, Yuan Zhou, Fangzhou Yin, Guoliang Dai, Lin Li, Bin Xu, De Ji, Yong Sun, Chunqin Mao, Tulin Lu. Comparative pharmacokinetics and tissue distribution of schisandrin, deoxyschisandrin and schisandrin B in rats after combining acupuncture and herb medicine (schisandra chinensis). Biomedical chromatography : BMC. 2014 Aug; 28(8):1075-83. doi: 10.1002/bmc.3122. [PMID: 24474333]
Xin Song, Pu Ding, Xian-Kuan Li, Ting Chen, Liang Chen, Bing Wang. [Effect of forchlorfenuron on fruit morphology and lignans content of Schisandra chinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 May; 39(9):1579-83. doi: . [PMID: 25095364]
Jung Nyeo Chun, Sang-Yeob Kim, Eun-Jung Park, Eun Jung Kwon, Dong-Jun Bae, In-San Kim, Hye Kyung Kim, Jong Kwan Park, Sung Won Lee, Hyun Ho Park, Insuk So, Ju-Hong Jeon. Schisandrin B suppresses TGFβ1-induced stress fiber formation by inhibiting myosin light chain phosphorylation. Journal of ethnopharmacology. 2014 Mar; 152(2):364-71. doi: 10.1016/j.jep.2014.01.024. [PMID: 24486209]
Libo Li, Tiran Zhang, Li Zhou, Li Zhou, Guihua Xing, Yuhang Chen, Yabing Xin. Schisandrin B attenuates acetaminophen-induced hepatic injury through heat-shock protein 27 and 70 in mice. Journal of gastroenterology and hepatology. 2014 Mar; 29(3):640-7. doi: 10.1111/jgh.12425. [PMID: 24219791]
Xudong Deng, Chong Shen, Qin Meng. Screening of herbal components for attenuating amiodarone-induced hepatotoxicity on gel-entrapped rat hepatocytes. Drug and chemical toxicology. 2014 Jan; 37(1):100-6. doi: 10.3109/01480545.2013.834347. [PMID: 24274456]
Yi Zhang, Si-Yuan Pan, Shu-Feng Zhou, Xiao-Yan Wang, Nan Sun, Pei-Li Zhu, Zhu-Sheng Chu, Zhi-Ling Yu, Kam-Ming Ko. Time and dose relationships between schisandrin B- and schisandrae fructus oil-induced hepatotoxicity and the associated elevations in hepatic and serum triglyceride levels in mice. Drug design, development and therapy. 2014; 8(?):1429-39. doi: 10.2147/dddt.s67518. [PMID: 25278745]
Wei-Liang Li, Hua-Wen Xin, Ai-Rong Yu, Xiao-Chun Wu. In vivo effect of Schisandrin B on cytochrome P450 enzyme activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013 Jun; 20(8-9):760-5. doi: 10.1016/j.phymed.2013.02.005. [PMID: 23523258]
Agnieszka Szopa, Halina Ekiert. Production of deoxyschizandrin and γ-schizandrin in shoot-differentiating and undifferentiating callus cultures of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia vine). Journal of biotechnology. 2013 Jun; 165(3-4):209-13. doi: 10.1016/j.jbiotec.2013.03.010. [PMID: 23562619]
Heyun Zhu, Xiurong Zhang, Jiao Guan, Baiji Cui, Longshan Zhao, Xu Zhao. Pharmacokinetics and tissue distribution study of schisandrin B in rats by ultra-fast liquid chromatography with tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2013 May; 78-79(?):136-40. doi: 10.1016/j.jpba.2013.01.041. [PMID: 23474814]
Bao-Lian Wang, Jin-Ping Hu, Li Sheng, Hui Chen, Yan Li. Chemical-pharmacokinetic-pharmacodynamic fingerprints of Schisandra chinensis alcoholic extract. Yao xue xue bao = Acta pharmaceutica Sinica. 2013 May; 48(5):734-40. doi: . [PMID: 23888698]
Binbin Wei, Qing Li, Dan Su, Ronghua Fan, Longshan Zhao, Lulu Geng, Bosai He, Xiaohui Chen, Ying Jia, Kaishun Bi. Development of a UFLC-MS/MS method for simultaneous determination of six lignans of Schisandra chinensis (Turcz.) Baill. in rat plasma and its application to a comparative pharmacokinetic study in normal and insomnic rats. Journal of pharmaceutical and biomedical analysis. 2013 Apr; 77(?):120-7. doi: 10.1016/j.jpba.2013.01.029. [PMID: 23416367]
Hiu Yee Kwan, Yong-Mei Hu, Chi Leung Chan, Hui-Hui Cao, Chi Yan Cheng, Si-Yuan Pan, Kai Wing Tse, Yiu Cheong Wu, Zhi-Ling Yu, Wang Fun Fong. Lipidomics identification of metabolic biomarkers in chemically induced hypertriglyceridemic mice. Journal of proteome research. 2013 Mar; 12(3):1387-98. doi: 10.1021/pr3010327. [PMID: 23336740]
Hui Sun, Fangfang Wu, Aihua Zhang, Wenfeng Wei, Ying Han, Xijun Wang. Pharmacokinetic study of schisandrin, schisandrol B, schisantherin A, deoxyschisandrin, and schisandrin B in rat plasma after oral administration of Shengmaisan formula by UPLC-MS. Journal of separation science. 2013 Feb; 36(3):485-91. doi: 10.1002/jssc.201200887. [PMID: 23303577]
Pengsheng Chen, Sisi Pang, Naiquan Yang, Haoyu Meng, Jia Liu, Ningtian Zhou, Min Zhang, Zhihui Xu, Wei Gao, Bo Chen, Zhengxian Tao, Liansheng Wang, Zhijian Yang. Beneficial effects of schisandrin B on the cardiac function in mice model of myocardial infarction. PloS one. 2013; 8(11):e79418. doi: 10.1371/journal.pone.0079418. [PMID: 24260217]
Si-Yuan Pan, Zhan-Hong Jia, Yi Zhang, Qing Yu, Xiao-Yan Wang, Nan Sun, Pei-Li Zhu, Zhi-Ling Yu, Kam-Ming Ko. Novel mouse model of combined hyperlipidemia associated with steatosis and liver injury by a single-dose intragastric administration of schisandrin B/cholesterol/bile salts mixture. Journal of pharmacological sciences. 2013; 123(2):110-9. doi: 10.1254/jphs.13087fp. [PMID: 24096833]
Tae Hwa Lee, Chang Hwa Jung, Dae-Hee Lee. Neuroprotective effects of Schisandrin B against transient focal cerebral ischemia in Sprague-Dawley rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2012 Dec; 50(12):4239-45. doi: 10.1016/j.fct.2012.08.047. [PMID: 22960133]
Mei Li, Jing Jin, Jia Li, Cui-Wen Guan, Wen-Wen Wang, Yu-Wen Qiu, Zhi-Ying Huang. [Schisandrin B protects against nephrotoxicity induced by cisplatin in HK-2 cells via Nrf2-ARE activation]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Nov; 47(11):1434-9. doi: . [PMID: 23387073]
Rahul Checker, Raghavendra S Patwardhan, Deepak Sharma, Jisha Menon, Maikho Thoh, Hari N Bhilwade, Tetsuya Konishi, Santosh K Sandur. Schisandrin B exhibits anti-inflammatory activity through modulation of the redox-sensitive transcription factors Nrf2 and NF-κB. Free radical biology & medicine. 2012 Oct; 53(7):1421-30. doi: 10.1016/j.freeradbiomed.2012.08.006. [PMID: 22917978]