gomisin N (BioDeep_00000230137)

 

Secondary id: BioDeep_00000003697, BioDeep_00000402987

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


(9R,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene

化学式: C23H28O6 (400.1886)
中文名称: 五味子素乙, 戈米辛 N, (+)-五味子乙素, 戈米辛N, 五味子醇甲, 异南五味子木脂宁, 五味子乙素
谱图信息: 最多检出来源 Viridiplantae(plant) 42.86%

分子结构信息

SMILES: CC(C1)C(C)CC2=CC(OC)=C(OC)C(OC)=C2C3=C1C=C4OCOC4=C3OC
InChI: InChI=1S/C23H28O6/c1-12-7-14-9-16(24-3)20(25-4)22(26-5)18(14)19-15(8-13(12)2)10-17-21(23(19)27-6)29-11-28-17/h9-10,12-13H,7-8,11H2,1-6H3

描述信息

(+)-schisandrin B is an organic heterotetracyclic compound that is found in Fructus Schisandrae and Schisandra chinensis. It has a role as a nephroprotective agent, an apoptosis inhibitor, a plant metabolite, an anti-asthmatic agent, an antioxidant, an anti-inflammatory agent, a neuroprotective agent, a hepatoprotective agent and an antilipemic drug. It is an organic heterotetracyclic compound, an aromatic ether, an oxacycle and a cyclic acetal.
gomisin N is a natural product found in Kadsura coccinea, Schisandra propinqua, and other organisms with data available.
An organic heterotetracyclic compound that is found in Fructus Schisandrae and Schisandra chinensis.
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
Gomisin N, isolated from Schisandra chinensis. Gomisin N has the potential for use in the treatment of allergy. Gomisin N is an anti-cancer agent candidate capable of inhibiting the proliferation and inducing the apoptosis in cancer[1][2][3].
Gomisin N, isolated from Schisandra chinensis. Gomisin N has the potential for use in the treatment of allergy. Gomisin N is an anti-cancer agent candidate capable of inhibiting the proliferation and inducing the apoptosis in cancer[1][2][3].
Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.
Schisandrin B (γ-Schisandrin) is a biphenylcyclooctadiene derivative isolated from Schisandra chinensis and has been shown to have antioxidant effects on the liver and heart of rodents.

同义名列表

40 个代谢物同义名

(9R,10S)-3,4,5,19-tetramethoxy-9,10-dimethyl-15,17-dioxatetracyclo[10.7.0.02,7.014,18]nonadeca-1(19),2,4,6,12,14(18)-hexaene; (6R,7S13aR)-1,2,3,13-tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydro-11H-benzo[3,4]cycloocta[1,2:4,5]benzo[1,2-d][1,3]dioxole; BENZO(3,4)CYCLOOCTA(1,2-F)(1,3)BENZODIOXOLE, 5,6,7,8-TETRAHYDRO-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYL-, (6R,7S,13AR)-REL-; Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13aR)-; benzo(3,4)cycloocta(1,2-F)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13AS)-; Benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxole, 5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, stereoisomer; (6R,7S)-1,2,3,13-Tetramethoxy-6,7-dimethyl-5,6,7,8-tetrahydrobenzo[3,4]cycloocta[1,2:4,5]benzo[1,2-d][1,3]dioxole; Benzo[3,4]cycloocta[1,2-f][1,3]benzodioxole,5,6,7,8-tetrahydro-1,2,3,13-tetramethoxy-6,7-dimethyl-, (6R,7S,13aS)-; (6R,7S,13AS)-5,6,7,8-TETRAHYDRO-1,2,3,13-TETRAMETHOXY-6,7-DIMETHYLBENZO(3,4)CYCLOOCTA(1,2-F)(1,3)BENZODIOXOLE; 1,2,3,12-tetramethoxy-6,7-dimethyl- 10,11-methylenedioxy-5,6,7,8-tetrahydrodibenzo[a,c]cyclooctene; SCHISANDRIN B (.GAMMA.-SCHISANDRIN) (CONSTITUENT OF NORTHERN SCHISANDRA) [DSC]; RTZKSTLPRTWFEV-OLZOCXBDSA-N; (+/-)-.GAMMA.-SCHIZANDRIN; (+/-)-.GAMMA.-SCHISANDRIN; (+--)-gamma-schizandrin; (+)-gamma-Schizandrin; SCHISANDRIN B, (+/-)-; .GAMMA.-SCHISANDRIN; .GAMMA.-SCHIZANDRIN; gamma-Schisandrin; ( )-Schisandrin B; gamma-schizandrin; (+)-schizandrin B; (+)-Schisandrin B; UNII-DKO6O75Z5V; UNII-02XA4X3KZW; Deoxygomisin A; schizandrin B; Isokadsuranin; (-)-gomisin N; schisandrin B; wuweizisu b; Schisandrin; DKO6O75Z5V; 02XA4X3KZW; Gomisin-N; gomisin N; AC1L4JAK; Deoxygomisin A; γ-Schisandrin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Miao Zhao, Jun Wu, Yuchen Jin, Min Li, KeXin Yu, Haibo Yu. Schisandrin B from Schisandra chinensis alleviated pain via glycine receptors, Nav1.7 channels and Cav2.2 channels. Journal of ethnopharmacology. 2024 May; 326(?):117996. doi: 10.1016/j.jep.2024.117996. [PMID: 38431110]
  • Michal Rybnikář, Milan Malaník, Karel Šmejkal, Emil Švajdlenka, Polina Shpet, Pavel Babica, Stefano Dall'Acqua, Ondřej Smištík, Ondřej Jurček, Jakub Treml. Dibenzocyclooctadiene Lignans from Schisandra chinensis with Anti-Inflammatory Effects. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063465. [PMID: 38542438]
  • Fei Hu, WenJie Hu, Hongming Xu. Schisandrin B Alleviates LPS Induced Mitochondrial Damage in C28I2 Cells. The Journal of membrane biology. 2024 Jan; ?(?):. doi: 10.1007/s00232-023-00299-5. [PMID: 38285126]
  • Feng-Rui Li, Yang Yu, Yu-Meng Du, Liang Kong, Yang Liu, Jia-Hua Wang, Mu-Han Chen, Mo Liu, Zi-Xu Zhang, Xue-Tao Li, Rui-Jun Ju. Borneol-Modified Schisandrin B Micelles Cross the Blood-Brain Barrier To Treat Alzheimer's Disease in Aged Mice. ACS chemical neuroscience. 2024 Jan; ?(?):. doi: 10.1021/acschemneuro.3c00625. [PMID: 38214579]
  • Jia Shang, Wenhui Yan, Xin Cui, Weina Ma, Zhuanzhuan Wang, Na Liu, Xinyao Yi, Tingli Guo, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Wei Cui, Lina Chen. Schisandrin B, a potential GLP-1R agonist, exerts anti-diabetic effects by stimulating insulin secretion. Molecular and cellular endocrinology. 2023 Jul; 577(?):112029. doi: 10.1016/j.mce.2023.112029. [PMID: 37495090]
  • Ho Yin Pekkle Lam, Ting-Ruei Liang, Shih-Yi Peng. Prevention of the Pro-Aggressive Effects of Ethanol-Intoxicated Mice by Schisandrin B. Nutrients. 2023 Apr; 15(8):. doi: 10.3390/nu15081909. [PMID: 37111128]
  • Caitao Dong, Chao Song, Ziqi He, Qianlin Song, Tianbao Song, Junwei Liu, Yunhe Xiong, Xiaozhe Su, Jiawei Zhou, Sixing Yang, Wenbiao Liao. Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3β/Nrf2 signaling-mediated ferroptosis in vivo and in vitro. International immunopharmacology. 2023 Apr; 117(?):110042. doi: 10.1016/j.intimp.2023.110042. [PMID: 36940552]
  • Chuang Li, Hyun Ju Oh, Haixing Liu, Min Kyu Kim. Schisandrin B protects boar spermatozoa against oxidative damage and increases their fertilization ability during in vitro storage. Theriogenology. 2023 Mar; 198(?):194-201. doi: 10.1016/j.theriogenology.2022.12.041. [PMID: 36592517]
  • Xiankuan Li, Ying Zhao, Sihan Gong, Tianbao Song, Jiaming Ge, Jiarong Li, Jian Zhang, Kun Fu, Yanchao Zheng, Lin Ma. Schisandrin B ameliorates acute liver injury by regulating EGFR-mediated activation of autophagy. Bioorganic chemistry. 2023 01; 130(?):106272. doi: 10.1016/j.bioorg.2022.106272. [PMID: 36403334]
  • Zhihua Zhang, Hongmin Guo, Zihui Hu, Congfa Zhou, Qixing Hu, Hao Peng, Gan Tang, Zehao Xiao, Lingzhi Pi, Guilin Li. Schisandrin B Alleviates Diabetic Cardiac Autonomic neuropathy Induced by P2X7 Receptor in Superior Cervical Ganglion via NLRP3. Disease markers. 2023; 2023(?):9956950. doi: 10.1155/2023/9956950. [PMID: 36660202]
  • Yiwen Zhang, Saiyu Li, Panpan Yang, Qian Zhang, Huarong Xu, Kaishun Bi, Qing Li. A multidimensional strategy for uncovering comprehensive quality markers of Schisandra chinensis (Turcz.) Baill based on pharmacodynamics and chemical properties. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154273. doi: 10.1016/j.phymed.2022.154273. [PMID: 36044818]
  • Wu Luo, Ke Lin, Junyi Hua, Jibo Han, Qiuyan Zhang, Lingfeng Chen, Zia A Khan, Gaojun Wu, Yi Wang, Guang Liang. Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88-Dependent Inflammation. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 11; 9(31):e2202590. doi: 10.1002/advs.202202590. [PMID: 36180407]
  • Li-Shan Yan, Shuo-Feng Zhang, Gan Luo, Brian Chi-Yan Cheng, Chao Zhang, Yi-Wei Wang, Xin-Yu Qiu, Xiao-Hong Zhou, Qing-Gao Wang, Xue-Lan Song, Si-Yuan Pan, Yi Zhang. Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK/mTOR signaling pathway. Metabolism: clinical and experimental. 2022 06; 131(?):155200. doi: 10.1016/j.metabol.2022.155200. [PMID: 35405150]
  • Ruojia Ma, Yike Zhan, Yamei Zhang, Liangan Wu, Xing Wang, Ming Guo. Schisandrin B ameliorates non-alcoholic liver disease through anti-inflammation activation in diabetic mice. Drug development research. 2022 05; 83(3):735-744. doi: 10.1002/ddr.21905. [PMID: 34927282]
  • Hongwei Shi, Yue Yan, Hong Yang, Peng Pu, Heng Tang. Schisandrin B Diet Inhibits Oxidative Stress to Reduce Ferroptosis and Lipid Peroxidation to Prevent Pirarubicin-Induced Hepatotoxicity. BioMed research international. 2022; 2022(?):5623555. doi: 10.1155/2022/5623555. [PMID: 36060128]
  • Xiufeng Chen, Zhen Xiao, Zhiyan Jiang, Yonghong Jiang, Wen Li, Mingjing Wang. Schisandrin B Attenuates Airway Inflammation and Airway Remodeling in Asthma by Inhibiting NLRP3 Inflammasome Activation and Reducing Pyroptosis. Inflammation. 2021 Dec; 44(6):2217-2231. doi: 10.1007/s10753-021-01494-z. [PMID: 34143347]
  • Jufeng Guo, Yingying Shen, Xia Lin, Honggang Chen, Jian Liu. Schisandrin B promotes TH1 cell differentiation by targeting STAT1. International immunopharmacology. 2021 Dec; 101(Pt A):108213. doi: 10.1016/j.intimp.2021.108213. [PMID: 34624651]
  • Zhiman Li, Lijuan Zhao, Yunshi Xia, Jianbo Chen, Mei Hua, Yinshi Sun. Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226882. [PMID: 34833975]
  • Lu Zhang, Liang Kong, Si-Yu He, Xin-Ze Liu, Yang Liu, Juan Zang, Rui-Jun Ju, Xue-Tao Li. The anti-ovarian cancer effect of RPV modified paclitaxel plus schisandra B liposomes in SK-OV-3 cells and tumor-bearing mice. Life sciences. 2021 Nov; 285(?):120013. doi: 10.1016/j.lfs.2021.120013. [PMID: 34614418]
  • Ee Taek Hwang, Ye Eun Joo, Ka Ram Kim, Jinhee Jeong. Biomineralized separation, concentration, and evaluation of the effectiveness of Schisandra chinensis fruit extract. Food chemistry. 2021 Oct; 360(?):130063. doi: 10.1016/j.foodchem.2021.130063. [PMID: 34029927]
  • Fu-Yi Cai, Xue-Min Yao, Ming Jing, Liang Kong, Jing-Jing Liu, Min Fu, Xin-Ze Liu, Lu Zhang, Si-Yu He, Xue-Tao Li, Rui-Jun Ju. Enhanced antitumour efficacy of functionalized doxorubicin plus schisandrin B co-delivery liposomes via inhibiting epithelial-mesenchymal transition. Journal of liposome research. 2021 Jun; 31(2):113-129. doi: 10.1080/08982104.2020.1745831. [PMID: 32200703]
  • Tzu-Yi Chiang, Hong-Jaan Wang, Yen-Cih Wang, Elise Chia-Hui Tan, I-Jung Lee, Chul-Ho Yun, Yune-Fang Ueng. Effects of Shengmai San on key enzymes involved in hepatic and intestinal drug metabolism in rats. Journal of ethnopharmacology. 2021 May; 271(?):113914. doi: 10.1016/j.jep.2021.113914. [PMID: 33571617]
  • Zeyu Ma, Gang Xu, Yingying Shen, Shufang Hu, Xia Lin, Jun Zhou, Wei Zhao, Jian Liu, Jiaoli Wang, Jufeng Guo. Schisandrin B-mediated TH17 cell differentiation attenuates bowel inflammation. Pharmacological research. 2021 04; 166(?):105459. doi: 10.1016/j.phrs.2021.105459. [PMID: 33545313]
  • Yaqin Chen, Yu Kong, Qili Wang, Jian Chen, Hua Chen, Huihui Xie, Lan Li. Schisandrin B Attenuates Airway Inflammation by Regulating the NF-κB/Nrf2 Signaling Pathway in Mouse Models of Asthma. Journal of immunology research. 2021; 2021(?):8029963. doi: 10.1155/2021/8029963. [PMID: 34258300]
  • Xiu-Ying Li, Luan-Xia Shi, Xue-Min Yao, Ming Jing, Qin-Qing Li, Ying-Li Wang, Qing-Shan Li. Functional vinorelbine plus schisandrin B liposomes destroying tumor metastasis in treatment of gastric cancer. Drug development and industrial pharmacy. 2021 Jan; 47(1):100-112. doi: 10.1080/03639045.2020.1862169. [PMID: 33295825]
  • Yan Fei, Shi Jiang-Pei, Chen Hai-Zhen, Shen Jun-Yi, Xie Xing-Mei, Jiang Zi-Fei, G U Xiao-Yan, Liu Ying, Feng Nian-Ping. [Preparation and evaluation of schisandrin B-loaded F127 modified lipid-polymer nanoparticles for inhibition of breast cancer lung metastasis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2020 Nov; 45(21):5177-5183. doi: 10.19540/j.cnki.cjcmm.20200819.305. [PMID: 33350233]
  • Joo Young Lee, Ji Hye Lee, Chong Kun Cheon. Functional Characterization of Gomisin N in High-Fat-Induced Drosophila Obesity Models. International journal of molecular sciences. 2020 Sep; 21(19):. doi: 10.3390/ijms21197209. [PMID: 33003580]
  • Su-Jin Ahn, Hyung Joo Kim, Ayoung Lee, Seung-Sik Min, Sangwhan In, Eunmi Kim. Determination of 12 herbal compounds for estimating the presence of Angelica Gigas Root, Cornus Fruit, Licorice Root, Pueraria Root, and Schisandra Fruit in foods by LC-MS/MS. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2020 Sep; 37(9):1437-1448. doi: 10.1080/19440049.2020.1778187. [PMID: 32530783]
  • Ming Jing, Xiao-Jie Bi, Xue-Min Yao, Fuyi Cai, Jing-Jing Liu, Min Fu, Liang Kong, Xin-Ze Liu, Lu Zhang, Si-Yu He, Lian-Qun Jia, Xue-Tao Li. Enhanced antitumor efficacy using epirubicin and schisandrin B co-delivery liposomes modified with PFV via inhibiting tumor metastasis. Drug development and industrial pharmacy. 2020 Apr; 46(4):621-634. doi: 10.1080/03639045.2020.1742145. [PMID: 32162988]
  • Kippeum Lee, Yeon-Joo Lee, Kui-Jin Kim, Sungwoo Chei, Heegu Jin, Hyun-Ji Oh, Boo-Yong Lee. Gomisin N from Schisandra chinensis Ameliorates Lipid Accumulation and Induces a Brown Fat-Like Phenotype through AMP-Activated Protein Kinase in 3T3-L1 Adipocytes. International journal of molecular sciences. 2020 Mar; 21(6):. doi: 10.3390/ijms21062153. [PMID: 32245100]
  • M I Nasser, Shuoji Zhu, Chen Chen, Mingyi Zhao, Huanlei Huang, Ping Zhu. A Comprehensive Review on Schisandrin B and Its Biological Properties. Oxidative medicine and cellular longevity. 2020; 2020(?):2172740. doi: 10.1155/2020/2172740. [PMID: 32256947]
  • Guangxu Cao, Shuang Li, Hezhan Shi, Peidi Yin, Jialing Chen, Huifeng Li, Ying Zhong, Li-Ting Diao, Bin Du. Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT. Toxicology and applied pharmacology. 2019 12; 385(?):114769. doi: 10.1016/j.taap.2019.114769. [PMID: 31697999]
  • Hai Zhang, Qingshan Chen, Arik Dahan, Jiyang Xue, Liwen Wei, Weifeng Tan, Guoqing Zhang. Transcriptomic analyses reveal the molecular mechanisms of schisandrin B alleviates CCl4-induced liver fibrosis in rats by RNA-sequencing. Chemico-biological interactions. 2019 Aug; 309(?):108675. doi: 10.1016/j.cbi.2019.05.041. [PMID: 31150632]
  • Yiwen Zhang, Xinyan Lv, Ran Liu, Mingyang Zhang, Haopeng Liu, Hao Gao, Qian Zhang, Huarong Xu, Qing Li, Kaishun Bi. An integrated strategy for ascertaining quality marker of Schisandra chinensis (Turcz.) Baill based on correlation analysis between depression-related monoaminergic metabolites and chemical components profiling. Journal of chromatography. A. 2019 Aug; 1598(?):122-131. doi: 10.1016/j.chroma.2019.03.056. [PMID: 31047662]
  • Bingsheng Yu, Dongdi Sheng, Qiumin Tan. Determination of Schisandrin A and Schisandrin B in Traditional Chinese Medicine Preparation Huganpian Tablet by RP-HPLC. Chemical & pharmaceutical bulletin. 2019 Jul; 67(7):713-716. doi: 10.1248/cpb.c18-00968. [PMID: 31006725]
  • Jian-Hua Qin, Jia-Ru Lin, Wen-Fei Ding, Wei-Hua Wu. Schisandrin B Improves the Renal Function of IgA Nephropathy Rats Through Inhibition of the NF-κB Signalling Pathway. Inflammation. 2019 Jun; 42(3):884-894. doi: 10.1007/s10753-018-0943-z. [PMID: 30519926]
  • Zhi-Rong Ji, Wei-Liang Xue, Ling Zhang. Schisandrin B Attenuates Inflammation in LPS-Induced Sepsis Through miR-17-5p Downregulating TLR4. Inflammation. 2019 Apr; 42(2):731-739. doi: 10.1007/s10753-018-0931-3. [PMID: 30506107]
  • Xiao-Long Hu, Cui Guo, Ji-Qin Hou, Jia-Hao Feng, Xiao-Qi Zhang, Fei Xiong, Wen-Cai Ye, Hao Wang. Stereoisomers of Schisandrin B Are Potent ATP Competitive GSK-3β Inhibitors with Neuroprotective Effects against Alzheimer's Disease: Stereochemistry and Biological Activity. ACS chemical neuroscience. 2019 02; 10(2):996-1007. doi: 10.1021/acschemneuro.8b00252. [PMID: 29944335]
  • Maarit Kortesoja, Elina Karhu, Elin Soffia Olafsdottir, Jona Freysdottir, Leena Hanski. Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cells. Free radical biology & medicine. 2019 02; 131(?):309-317. doi: 10.1016/j.freeradbiomed.2018.12.019. [PMID: 30578916]
  • Zhenxin Mou, Zhiguo Feng, Zheng Xu, Fei Zhuang, Xuyong Zheng, Xiaokun Li, Jianchang Qian, Guang Liang. Schisandrin B alleviates diabetic nephropathy through suppressing excessive inflammation and oxidative stress. Biochemical and biophysical research communications. 2019 01; 508(1):243-249. doi: 10.1016/j.bbrc.2018.11.128. [PMID: 30477745]
  • Hong-Jaan Wang, Chung-Kuang Lu, Wei-Ching Chen, An-Chi Chen, Yune-Fang Ueng. Shenmai-Yin decreased the clearance of nifedipine in rats: The involvement of time-dependent inhibition of nifedipine oxidation. Journal of food and drug analysis. 2019 01; 27(1):284-294. doi: 10.1016/j.jfda.2018.10.005. [PMID: 30648582]
  • Ming Ding, Peng Shu, Shuang Gao, Fenglou Wang, Yitian Gao, Yu Chen, Wenjuan Deng, Gaiying He, Zhenlin Hu, Tianduo Li. Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway. International journal of molecular medicine. 2018 Dec; 42(6):3571-3581. doi: 10.3892/ijmm.2018.3901. [PMID: 30272282]
  • Jia-Wei Wang, Feng-Yin Liang, Xiang-Shuo Ouyang, Pei-Bo Li, Zhong Pei, Wei-Wei Su. Evaluation of neuroactive effects of ethanol extract of Schisandra chinensis, Schisandrin, and Schisandrin B and determination of underlying mechanisms by zebrafish behavioral profiling. Chinese journal of natural medicines. 2018 Dec; 16(12):916-925. doi: 10.1016/s1875-5364(18)30133-x. [PMID: 30595216]
  • Dawei Li, Aijing Leng, Yan Qi, Ruichen Wang, Lianhong Yin, Xu Han, Chengpeng Sun, Xingjie Guo, Linlin Fang, Jinyong Peng. Simultaneous quantification of Schisandrin B enantiomers in rat plasma by chiral LC-MS/MS: Application in a stereoselective pharmacokinetic study. Journal of pharmaceutical and biomedical analysis. 2018 Sep; 159(?):186-191. doi: 10.1016/j.jpba.2018.06.056. [PMID: 29990885]
  • Arulkumar Nagappan, Dae Young Jung, Ji-Hyun Kim, Hoyoung Lee, Myeong Ho Jung. Gomisin N Alleviates Ethanol-Induced Liver Injury through Ameliorating Lipid Metabolism and Oxidative Stress. International journal of molecular sciences. 2018 Sep; 19(9):. doi: 10.3390/ijms19092601. [PMID: 30200508]
  • Qiang Liu, Jinxin Song, Hong Li, Lei Dong, Shejiao Dai. Schizandrin B inhibits the cis‑DDP‑induced apoptosis of HK‑2 cells by activating ERK/NF‑κB signaling to regulate the expression of survivin. International journal of molecular medicine. 2018 Apr; 41(4):2108-2116. doi: 10.3892/ijmm.2018.3409. [PMID: 29393335]
  • Xuyong Zhao, Yijia Xiang, Changhong Cai, Aiming Zhou, Ning Zhu, Chunlai Zeng. Schisandrin B protects against myocardial ischemia/reperfusion injury via the PI3K/Akt pathway in rats. Molecular medicine reports. 2018 Jan; 17(1):556-561. doi: 10.3892/mmr.2017.7926. [PMID: 29115607]
  • Dae Young Jung, Ji-Hyun Kim, Hoyoung Lee, Myeong Ho Jung. Antidiabetic effect of gomisin N via activation of AMP-activated protein kinase. Biochemical and biophysical research communications. 2017 12; 494(3-4):587-593. doi: 10.1016/j.bbrc.2017.10.120. [PMID: 29079190]
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  • Qiao Lai, Zhengzhong Luo, Chunying Wu, Sisi Lai, Hanmei Wei, Tongming Li, Qing Wang, Yang Yu. Attenuation of cyclosporine A induced nephrotoxicity by schisandrin B through suppression of oxidative stress, apoptosis and autophagy. International immunopharmacology. 2017 Nov; 52(?):15-23. doi: 10.1016/j.intimp.2017.08.019. [PMID: 28846887]
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