Noroxylin (BioDeep_00000003622)

Main id: BioDeep_00000229862

 

human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


5,6,7-trihydroxy-2-phenylchromen-4-one

化学式: C15H10O5 (270.052821)
中文名称: 黄芩素, 黄芩苷元
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(cc2=O)c1ccccc1)O)O)O
InChI: InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D011448 - Prostaglandin Antagonists
D020011 - Protective Agents > D000975 - Antioxidants
COVID info from PDB, Protein Data Bank
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.
Baicalein (5,6,7-Trihydroxyflavone) is a xanthine oxidase inhibitor with an IC50 value of 3.12 μM.

同义名列表

5 个代谢物同义名

5,6,7-trihydroxy-2-phenylchromen-4-one; 5,6,7-Trihydroxyflavone; Noroxylin; Baicalein; Baicalein



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

33 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(31)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yanqin Luo, Bo Lin, Peng Yu, Di Zhang, Yingfan Hu, Xianli Meng, Li Xiang. Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155706. doi: 10.1016/j.phymed.2024.155706. [PMID: 38723528]
  • Ying-Ying Li, Yi-Qiu Peng, Yu-Xi Yang, Ting-Juan Shi, Rui-Xia Liu, Ying-Yi Luan, Cheng-Hong Yin. Baicalein improves the symptoms of polycystic ovary syndrome by mitigating oxidative stress and ferroptosis in the ovary and gravid placenta. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155423. doi: 10.1016/j.phymed.2024.155423. [PMID: 38518646]
  • Juyeong Cho, Eun-Bin Hong, Young-Sik Kim, Jungbin Song, Yeon Ha Ju, Hyunjin Kim, Hyowon Lee, Hocheol Kim, Min-Ho Nam. Baicalin and baicalein from Scutellaria baicalensis Georgi alleviate aberrant neuronal suppression mediated by GABA from reactive astrocytes. CNS neuroscience & therapeutics. 2024 05; 30(5):e14740. doi: 10.1111/cns.14740. [PMID: 38715318]
  • Weifan Huang, Yihan Qian, Jiacheng Lin, Fang Wang, Xiaoni Kong, Weifeng Tan. Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner. Biochemical and biophysical research communications. 2024 Apr; 705(?):149670. doi: 10.1016/j.bbrc.2024.149670. [PMID: 38442444]
  • Xi Qin, Yali Wu, Ya Zhao, Shangshang Qin, Qiuru Ji, Jinhao Jia, Mengqi Huo, Xiaoyu Zhao, Qing Ma, Xiaoyan Wang, Xiaofei Chen, Hui Zhang, Mingliang Zhang, Liuqing Yang, Weixia Li, Jinfa Tang. Revealing active constituents within traditional Chinese Medicine used for treating bacterial pneumonia, with emphasis on the mechanism of baicalein against multi-drug resistant Klebsiella pneumoniae. Journal of ethnopharmacology. 2024 Mar; 321(?):117488. doi: 10.1016/j.jep.2023.117488. [PMID: 38008277]
  • Nan Hu, Fang-Yin Jin, Miao-Miao Gao, Lian-Jie Liu, Jin-Hui Wang, Bao-Feng Yang, Chun-Li Li. Baicalein improves Na2SeO3 induced cataract by enhancing the antioxidant capacity of juvenile Sprague Dawley Rat. Journal of ethnopharmacology. 2024 Feb; 320(?):117433. doi: 10.1016/j.jep.2023.117433. [PMID: 37979815]
  • Wang Peng, Qinxuan Xia, Yue Zhang, Danfeng Cao, Xiangrong Zheng. VEGF and EGFR signaling pathways are involved in the baicalein attenuation of OVA-induced airway inflammation and airway remodeling in mice. Respiratory research. 2024 Jan; 25(1):10. doi: 10.1186/s12931-023-02637-6. [PMID: 38178132]
  • Ruolei Wang, Chunyan Wang, Lianheng Lu, Fuwen Yuan, Feng He. Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives. Pharmacological research. 2024 Jan; 199(?):107032. doi: 10.1016/j.phrs.2023.107032. [PMID: 38061594]
  • Yuan Ji-Hong, Ma Yu, Yuan Ling-Hong, Gong Jing-Jing, Xu Ling-Li, Wang Lv, Jin Yong-Mei. Baicalein attenuates bleomycin-induced lung fibroblast senescence and lung fibrosis through restoration of Sirt3 expression. Pharmaceutical biology. 2023 Dec; 61(1):288-297. doi: 10.1080/13880209.2022.2160767. [PMID: 36815239]
  • Jingbo Pei, Yuanyuan Zou, Wenying Zhou, Yakun Wang. Baicalein, a component of banxia xiexin decoction, alleviates CPT-11-induced gastrointestinal dysfunction by inhibiting ALOX15-mediated ferroptosis. Chemical biology & drug design. 2023 Sep; ?(?):. doi: 10.1111/cbdd.14349. [PMID: 37735740]
  • Meiling Yu, Hongyu Li, Boying Wang, Zhenxiang Wu, Sheng Wu, Guojun Jiang, Huaxue Wang, Yingying Huang. Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation. Chemico-biological interactions. 2023 Sep; 382(?):110607. doi: 10.1016/j.cbi.2023.110607. [PMID: 37354967]
  • Jing Yang, Aner Chen, Xiaobo He, Shuangji Lu. Fabrication of baicalein-encapsulated zeolitic imidazole framework as a novel nanocomposited wound closure material to persuade pH-responsive healing efficacy in post-caesarean section wound care. International wound journal. 2023 Aug; 20(6):1921-1933. doi: 10.1111/iwj.14052. [PMID: 36572003]
  • Saswat Kumar Mohanty, Kitlangki Suchiang. Baicalein mitigates oxidative stress and enhances lifespan through modulation of Wnt ligands and GATA factor: ELT-3 in Caenorhabditis elegans. Life sciences. 2023 Jul; 329(?):121946. doi: 10.1016/j.lfs.2023.121946. [PMID: 37463652]
  • Mingxiao Liu, Di Zhang, Dongqiang Wang, Xiaodong Wu, Ying Zhang, Jigang Yin, Guan Zhu. Cost-effective In vivo and In vitro Mouse Models for Evaluating Anti-Cryptosporidial Drug Efficacy: Assessing Vorinostat, Docetaxel and Baicalein. The Journal of infectious diseases. 2023 Jul; ?(?):. doi: 10.1093/infdis/jiad243. [PMID: 37418629]
  • Shuna Zhang, Ying Wang, Jiaojiao Shan, Xueju Qi, Qun Liu. Improved Bioavailability and Hepatoprotective Activity of Baicalein Via a Self-assembled Solutol HS15 Micelles System. Current drug delivery. 2023 Jun; ?(?):. doi: 10.2174/1567201820666230606163452. [PMID: 37282637]
  • Li Gao, Yu-Xin Liu, Yu-Zhi Zhou, Xue-Mei Qin. Baicalein Attenuates Neuroinflammation in LPS-Treated BV-2 Cells by Inhibiting Glycolysis via STAT3/c-Myc Pathway. Neurochemical research. 2023 Jun; ?(?):. doi: 10.1007/s11064-023-03961-5. [PMID: 37277556]
  • Hanlin Shi, Lingling Deng, Yaolong Zhou, Hang Yu, Xi Huang, Mengmeng Chen, Yang Lei, Jingcheng Dong. Network pharmacology and experiments in vivo and in vitro reveal that the Jia-Wei-Bu-Shen-Yi-Qi formula (JWBSYQF) and its active ingredient baicalein ameliorate BLM-induced lung fibrosis in mice via PI3K/Akt signaling pathway. Journal of ethnopharmacology. 2023 May; 315(?):116691. doi: 10.1016/j.jep.2023.116691. [PMID: 37247682]
  • Bangzuo Ning, Jingjing Shen, Fanglin Liu, Hemin Zhang, Xin Jiang. Baicalein Suppresses NLRP3 and AIM2 Inflammasome-Mediated Pyroptosis in Macrophages Infected by Mycobacterium tuberculosis via Induced Autophagy. Microbiology spectrum. 2023 May; ?(?):e0471122. doi: 10.1128/spectrum.04711-22. [PMID: 37125940]
  • Xin-Mei Xie, Jiao-Jiao Hao, Jun-Zhuo Shi, Yun-Feng Zhou, Peng-Fei Liu, Feng Wang, Xiao-Ming Zheng, Xiu-Ying Yu, Chen-Chen Wang, Yi Yan, Guan-Hua Du, Jun-Ke Song, Yang-Yang He, Xiao-Bin Pang. Baicalein ameliorates Alzheimer's disease via orchestration of CX3CR1/NF-κB pathway in a triple transgenic mouse model. International immunopharmacology. 2023 May; 118(?):109994. doi: 10.1016/j.intimp.2023.109994. [PMID: 37098656]
  • Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents. Journal of natural products. 2023 Apr; 86(4):1061-1073. doi: 10.1021/acs.jnatprod.3c00159. [PMID: 37043739]
  • Yuhang Wang, Junfeng Su, Ziyan Zhou, Jie Yang, Wenjuan Liu, Yafen Zhang, Pengyu Zhang, Tingting Guo, Guocai Li. Baicalein Resensitizes Multidrug-Resistant Gram-Negative Pathogens to Doxycycline. Microbiology spectrum. 2023 Apr; ?(?):e0470222. doi: 10.1128/spectrum.04702-22. [PMID: 37070985]
  • Shuya Xue, Min Shi, Jinye Wang, Jiapeng Li, Guanwei Peng, Jingkun Xu, Yansha Gao, Xuemin Duan, Limin Lu. TiO2-MXene/PEDOT:PSS Composite as a Novel Electrochemical Sensing Platform for Sensitive Detection of Baicalein. Molecules (Basel, Switzerland). 2023 Apr; 28(7):. doi: 10.3390/molecules28073262. [PMID: 37050025]
  • Tiansheng Zheng, Haipeng Liu, Yifan Hong, Yajuan Cao, Qing Xia, Chengge Qin, Ming Li, Russel J Reiter, Yidong Bai, Lihong Fan. Promotion of liquid-to-solid phase transition of cGAS by Baicalein suppresses lung tumorigenesis. Signal transduction and targeted therapy. 2023 Mar; 8(1):133. doi: 10.1038/s41392-023-01326-6. [PMID: 36944610]
  • Xiaomeng Zhang, Jingcong Xie, Shiping Cao, Haiyan Zhang, Jianjun Pei, Su Bu, Linguo Zhao. Efficient production of the glycosylated derivatives of baicalein in engineered Escherichia coli. Applied microbiology and biotechnology. 2023 Mar; ?(?):. doi: 10.1007/s00253-023-12464-w. [PMID: 36930276]
  • I-Chieh Wang, Jian-Hong Lin, Wen-Sen Lee, Chin-Hung Liu, Ting-Yuan Lin, Kun-Ta Yang. Baicalein and luteolin inhibit ischemia/reperfusion-induced ferroptosis in rat cardiomyocytes. International journal of cardiology. 2023 03; 375(?):74-86. doi: 10.1016/j.ijcard.2022.12.018. [PMID: 36513286]
  • Xiao Han, Jiayan Huang, Jia Lu, Feng He, Fang Wang, Shuangfeng Li, Hao Zhong, Haiyang Yu, Weiling Pu. Active compounds and potential targets of Shuganning injection in the treatment of hepatocellular carcinoma by network pharmacology and in vitro validation. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Mar; ?(?):. doi: 10.1007/s00210-023-02432-6. [PMID: 36869905]
  • Lina Ruan, Kaiyu Guan, Yue Wang, Ming Gu, Yue Chen, Lisha Cai, Ruixuan Ye, Zhengwei Huang, Anqi Guo, Zhengkang Su, Xi Li, Jianchun Pan. Baicalein exerts anxiolytic and antinociceptive effects in a mouse model of posttraumatic stress disorder: Involvement of the serotonergic system and spinal delta-opioid receptors. Progress in neuro-psychopharmacology & biological psychiatry. 2023 03; 122(?):110689. doi: 10.1016/j.pnpbp.2022.110689. [PMID: 36462602]
  • Marcelina Chmiel, Monika Stompor-Gorący. Promising Role of the Scutellaria baicalensis Root Hydroxyflavone-Baicalein in the Prevention and Treatment of Human Diseases. International journal of molecular sciences. 2023 Mar; 24(5):. doi: 10.3390/ijms24054732. [PMID: 36902160]
  • Bohan Tang, Yue Dong. Network pharmacology and bioinformatics analysis on the underlying mechanisms of baicalein against oral squamous cell carcinoma. The journal of gene medicine. 2023 Feb; ?(?):e3490. doi: 10.1002/jgm.3490. [PMID: 36843559]
  • Chunyu Guo, Qingjun Li, Rihong Chen, Wenhui Fan, Xin Zhang, Yuqian Zhang, Lanping Guo, Xiao Wang, Xinyan Qu, Hongjing Dong. Baicalein alleviates non-alcoholic fatty liver disease in mice by ameliorating intestinal barrier dysfunction. Food & function. 2023 Feb; 14(4):2138-2148. doi: 10.1039/d2fo03015b. [PMID: 36752061]
  • Yunpeng Wan, Kai Shen, Haiyang Yu, Weimin Fan. Baicalein limits osteoarthritis development by inhibiting chondrocyte ferroptosis. Free radical biology & medicine. 2023 02; 196(?):108-120. doi: 10.1016/j.freeradbiomed.2023.01.006. [PMID: 36657732]
  • Hao Wang, Yantong Sun, Wei Guo, Jing Wang, Jingyi Gao, Wenwen Peng, Jingkai Gu. Identification and high-throughput quantification of baicalein and its metabolites in plasma and urine. Journal of ethnopharmacology. 2023 Jan; 301(?):115853. doi: 10.1016/j.jep.2022.115853. [PMID: 36272493]
  • Sai Ying, Haihao Yang, Qianlan Gu, Zhao Wu, Nanting Zou, Chong-Zhi Wang, Chunping Wan, Chun-Su Yuan. The Small-Molecule compound baicalein alleviates experimental autoimmune encephalomyelitis by suppressing pathogenetic CXCR6+ CD4 cells. International immunopharmacology. 2023 Jan; 114(?):109562. doi: 10.1016/j.intimp.2022.109562. [PMID: 36508914]
  • Md Reyad-Ul-Ferdous, Yongfeng Song. Baicalein modulates mitochondrial function by upregulating mitochondrial uncoupling protein-1 (UCP1) expression in brown adipocytes, cytotoxicity, and computational studies. International journal of biological macromolecules. 2022 Dec; 222(Pt B):1963-1973. doi: 10.1016/j.ijbiomac.2022.09.285. [PMID: 36252624]
  • Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh. Protective and therapeutic effects of Scutellaria baicalensis and its main active ingredients baicalin and baicalein against natural toxicities and physical hazards: a review of mechanisms. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2022 Dec; 30(2):351-366. doi: 10.1007/s40199-022-00443-x. [PMID: 35870110]
  • Xiaoran Ma, Shuang Wang, Chenglin Li, Xihui Jia, Tiantian Wang, Zhe Leng, Ran Lu, Xiaowen Kong, Jinyu Zhang, Ling Li. Baicalein inhibits the polarization of microglia/macrophages to the M1 phenotype by targeting STAT1 in EAE mice. International immunopharmacology. 2022 Dec; 113(Pt A):109373. doi: 10.1016/j.intimp.2022.109373. [PMID: 36279665]
  • Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh. Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review. Naunyn-Schmiedeberg's archives of pharmacology. 2022 11; 395(11):1297-1329. doi: 10.1007/s00210-022-02258-8. [PMID: 35676380]
  • Shambhoo Sharan Tripathi, Raushan Kumar, Akalabya Bissoyi, Syed Ibrahim Rizvi. Baicalein maintains redox balance in experimental hyperlipidemic rats. Archives of physiology and biochemistry. 2022 Oct; 128(5):1156-1164. doi: 10.1080/13813455.2020.1760890. [PMID: 32393069]
  • Ming Li, Zhaoli Meng, Shichao Yu, Jiarui Li, Yupeng Wang, Wei Yang, Hui Wu. Baicalein ameliorates cerebral ischemia-reperfusion injury by inhibiting ferroptosis via regulating GPX4/ACSL4/ACSL3 axis. Chemico-biological interactions. 2022 Oct; 366(?):110137. doi: 10.1016/j.cbi.2022.110137. [PMID: 36055377]
  • Zi-Zhen Zhang, Xiao-Hua Yu, Wei-Hua Tan. Baicalein inhibits macrophage lipid accumulation and inflammatory response by activating the PPARγ/LXRα pathway. Clinical and experimental immunology. 2022 09; 209(3):316-325. doi: 10.1093/cei/uxac062. [PMID: 35749304]
  • Xi-Jing Qian, He-Yang Zhou, Yan Liu, Jia-Xiao Dong, Wan-Da Tang, Ping Zhao, Hai-Lin Tang, Yong-Sheng Jin. Synthesis of baicalein derivatives and evaluation of their antiviral activity against arboviruses. Bioorganic & medicinal chemistry letters. 2022 09; 72(?):128863. doi: 10.1016/j.bmcl.2022.128863. [PMID: 35738350]
  • Caiyun Chen, Gaotian Li, Long Dai, Huijuan Zhao, Ning Li, Wei Mi, Shuying Yin, Shaoping Wang, Jiayu Zhang. Simultaneous separation of glycyrrhizic acid, baicalein and wogonin from Radix Glycyrrhizae and Radix Scutellariae using foam fractionation and in vitro activity evaluation. Journal of the science of food and agriculture. 2022 Sep; 102(12):5200-5209. doi: 10.1002/jsfa.11872. [PMID: 35289954]
  • Naveenkumar Chandrashekar, Anandakumar Pandi. Baicalein: A review on its anti-cancer effects and mechanisms in lung carcinoma. Journal of food biochemistry. 2022 09; 46(9):e14230. doi: 10.1111/jfbc.14230. [PMID: 35543192]
  • Nadja Kampschulte, Tim Berking, Ibrahim E Çelik, Stefan F Kirsch, Nils Helge Schebb. Inhibition of cytochrome P450 monooxygenase-catalyzed oxylipin formation by flavonoids: Evaluation of structure-activity relationship towards CYP4F2-selective inhibitors. European journal of medicinal chemistry. 2022 Aug; 238(?):114332. doi: 10.1016/j.ejmech.2022.114332. [PMID: 35576701]
  • Lin Wang, Ting Feng, Zhilian Su, Chao Pi, Yumeng Wei, Ling Zhao. Latest research progress on anticancer effect of baicalin and its aglycone baicalein. Archives of pharmacal research. 2022 Aug; 45(8):535-557. doi: 10.1007/s12272-022-01397-z. [PMID: 35908250]
  • Debajeet Ghosh, Sneha Bansode, Rakesh Joshi, Baban Kolte, Rajesh Gacche. Molecular elucidation of pancreatic elastase inhibition by baicalein. Journal of biomolecular structure & dynamics. 2022 08; 40(13):5759-5768. doi: 10.1080/07391102.2021.1873189. [PMID: 33446085]
  • Lidan Cui, Tianyi Yuan, Zuomei Zeng, Dianlong Liu, Chenxiao Liu, Jian Guo, Yucai Chen. Mechanistic and therapeutic perspectives of baicalin and baicalein on pulmonary hypertension: A comprehensive review. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jul; 151(?):113191. doi: 10.1016/j.biopha.2022.113191. [PMID: 35643068]
  • Dongni Ji, Jianhua Li, Yuhong Ren, Yong Wang. Rational engineering in Escherichia coli for high-titer production of baicalein based on genome-scale target identification. Biotechnology and bioengineering. 2022 07; 119(7):1916-1925. doi: 10.1002/bit.28087. [PMID: 35312063]
  • Monika Janeczko, Dominika Gmur, Elżbieta Kochanowicz, Kamila Górka, Tomasz Skrzypek. Inhibitory effect of a combination of baicalein and quercetin flavonoids against Candida albicans strains isolated from the female reproductive system. Fungal biology. 2022 Jun; 126(6-7):407-420. doi: 10.1016/j.funbio.2022.05.002. [PMID: 35667828]
  • Ting Xiao, Mengqi Cui, Caijuan Zheng, Peipei Zhang, Shanfa Ren, Jiali Bao, Dandi Gao, Ronghao Sun, Ming Wang, Jianping Lin, Liang Zhang, Mingjiang Li, Dongmei Li, Honggang Zhou, Cheng Yang. Both Baicalein and Gallocatechin Gallate Effectively Inhibit SARS-CoV-2 Replication by Targeting Mpro and Sepsis in Mice. Inflammation. 2022 Jun; 45(3):1076-1088. doi: 10.1007/s10753-021-01602-z. [PMID: 34822072]
  • Erna Sulistyowati, Jong-Hau Hsu, Szu-Jung Lee, Shang-En Huang, Widya Yanti Sihotang, Bin-Nan Wu, Zen-Kong Dai, Ming-Chung Lin, Jwu-Lai Yeh. Potential Actions of Baicalein for Preventing Vascular Calcification of Smooth Muscle Cells In Vitro and In Vivo. International journal of molecular sciences. 2022 May; 23(10):. doi: 10.3390/ijms23105673. [PMID: 35628483]
  • Jingjing Liao, Lei Xie, Tingyao Liu, Changming Mo, Shengrong Cui, Xunli Jia, Xiyang Huang, Zuliang Luo, Xiaojun Ma. Heterologous Biosynthesis of Health-Promoting Baicalein in Lycopersicon esculentum. Molecules (Basel, Switzerland). 2022 May; 27(10):. doi: 10.3390/molecules27103086. [PMID: 35630564]
  • Xiaolei Yang, Guanghao Zhu, Ying Zhang, Xubo Wu, Bei Liu, Ye Liu, Qing Yang, Wandi Du, Jingru Liang, Jiarong Hu, Ping Yang, Guangbo Ge, Weimin Cai, Guo Ma. Inhibition of Human UDP-Glucuronosyltransferases1A1-Mediated Bilirubin Glucuronidation by the Popular Flavonoids Baicalein, Baicalin, and Hyperoside Is Responsible for Herb (Shuang-Huang-Lian)-Induced Jaundice. Drug metabolism and disposition: the biological fate of chemicals. 2022 05; 50(5):552-565. doi: 10.1124/dmd.121.000714. [PMID: 35241486]
  • Zhilan Qian, Jiahui Yu, Xinjie Chen, Yijia Kang, Yanna Ren, Qi Liu, Jian Lu, Qing Zhao, Menghao Cai. De Novo Production of Plant 4'-Deoxyflavones Baicalein and Oroxylin A from Ethanol in Crabtree-Negative Yeast. ACS synthetic biology. 2022 04; 11(4):1600-1612. doi: 10.1021/acssynbio.2c00026. [PMID: 35389625]
  • Shambhoo Sharan Tripathi, Raushan Kumar, Akalabya Bissoyi, Syed Ibrahim Rizvi. Baicalein May Act as a Caloric Restriction Mimetic Candidate to Improve the Antioxidant Profile in a Natural Rodent Model of Aging. Rejuvenation research. 2022 Apr; 25(2):70-78. doi: 10.1089/rej.2021.0071. [PMID: 35316094]
  • Jie Li, Yang Wang, Tong Wu, Si Li, Ya-Nan Sun, Zhi-Hui Liu. Baicalein suppresses high glucose-induced inflammation and apoptosis in trophoblasts by targeting the miRNA-17-5p-Mfn1/2-NF-κB pathway. Placenta. 2022 04; 121(?):126-136. doi: 10.1016/j.placenta.2022.02.013. [PMID: 35306433]
  • Kowit Hengphasatporn, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Warinthorn Chavasiri, Peerapat Visitchanakun, Asada Leelahavanichkul, Wattamon Paunrat, Siwaporn Boonyasuppayakorn, Thanyada Rungrotmongkol, Supot Hannongbua, Yasuteru Shigeta. Halogenated Baicalein as a Promising Antiviral Agent toward SARS-CoV-2 Main Protease. Journal of chemical information and modeling. 2022 03; 62(6):1498-1509. doi: 10.1021/acs.jcim.1c01304. [PMID: 35245424]
  • Amira Awadalla, Mohamed R Mahdi, Mohamed H Zahran, Ahmed Abdelbaset-Ismail, Mohamed El-Dosoky, Amr Negm. Baicalein and Αlpha-Tocopherol Inhibit Toll-like Receptor Pathways in Cisplatin-Induced Nephrotoxicity. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072179. [PMID: 35408581]
  • Bo Hou, Yu-Min Zhang, Han-Yi Liao, Li-Feng Fu, De-Dong Li, Xin Zhao, Jian-Xun Qi, Wei Yang, Geng-Fu Xiao, Lian Yang, Zheng-Yu Zuo, Lin Wang, Xiang-Lei Zhang, Fang Bai, Liu Yang, George F Gao, Hao Song, Jiang-Miao Hu, Wei-Juan Shang, Jun Zhou. Target-Based Virtual Screening and LC/MS-Guided Isolation Procedure for Identifying Phloroglucinol-Terpenoid Inhibitors of SARS-CoV-2. Journal of natural products. 2022 02; 85(2):327-336. doi: 10.1021/acs.jnatprod.1c00805. [PMID: 35084181]
  • Muhammad Ali Khan, Purba Nag, Anca Grivei, Kurt T K Giuliani, Xiangju Wang, Vishal Diwan, Wendy Hoy, Helen Healy, Glenda Gobe, Andrew J Kassianos. Adenine overload induces ferroptosis in human primary proximal tubular epithelial cells. Cell death & disease. 2022 02; 13(2):104. doi: 10.1038/s41419-022-04527-z. [PMID: 35110539]
  • Yi Wu, Xinqiao Liu, Guiwei Li. Integrated bioinformatics and network pharmacology to identify the therapeutic target and molecular mechanisms of Huangqin decoction on ulcerative Colitis. Scientific reports. 2022 01; 12(1):159. doi: 10.1038/s41598-021-03980-8. [PMID: 34997010]
  • Meng Tong, Xiaoyan Wu, Shuya Zhang, Di Hua, Shukun Li, Xiangyu Yu, Jing Wang, Zhenhai Zhang. Application of TPGS as an efflux inhibitor and a plasticizer in baicalein solid dispersion. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2022 Jan; 168(?):106071. doi: 10.1016/j.ejps.2021.106071. [PMID: 34774716]
  • Cholil Yun, Shengfang Wang, Yuan Gao, Zhuowen Zhao, Na Miao, Yutong Shi, Ilbong Ri, Wenjie Wang, Huimei Wang. Optimization of ultrasound-assisted enzymatic pretreatment for enhanced extraction of baicalein and wogonin from Scutellaria baicalensis roots. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jan; 1188(?):123077. doi: 10.1016/j.jchromb.2021.123077. [PMID: 34894479]
  • Chenxiang Wang, Yibin Sun, Wenjing Liu, Yang Liu, Sualiha Afzal, Jahnavi Grover, Dennis Chang, Gerald Münch, Chun Guang Li, Shiling Lin, Jianyu Chen, Yiping Zhang, Zaixing Cheng, Yanxiang Lin, Yanfang Zheng, Mingqing Huang, Xian Zhou. Protective effect of the curcumin-baicalein combination against macrovascular changes in diabetic angiopathy. Frontiers in endocrinology. 2022; 13(?):953305. doi: 10.3389/fendo.2022.953305. [PMID: 36060932]
  • Man Zhang, Lili Ye, Chuanjing Cheng, Fukui Shen, Lin Niu, Yuanyuan Hou, Gang Bai. Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or Pseudomonas aeruginosa in Mice via Regulating the Expression and Phosphorylation of AKT. Nutrients. 2021 Dec; 13(12):. doi: 10.3390/nu13124462. [PMID: 34960014]
  • Zhao Tianyu, Guan Liying. Identifying the molecular targets and mechanisms of xuebijing injection for the treatment of COVID-19 via network parmacology and molecular docking. Bioengineered. 2021 12; 12(1):2274-2287. doi: 10.1080/21655979.2021.1933301. [PMID: 34077310]
  • Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin, Chien-Ming Hsieh. CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas. Drug delivery. 2021 Dec; 28(1):2205-2217. doi: 10.1080/10717544.2021.1989087. [PMID: 34662257]
  • Hongbo Liu, Fei Ye, Qi Sun, Hao Liang, Chunmei Li, Siyang Li, Roujian Lu, Baoying Huang, Wenjie Tan, Luhua Lai. Scutellaria baicalensis extract and baicalein inhibit replication of SARS-CoV-2 and its 3C-like protease in vitro. Journal of enzyme inhibition and medicinal chemistry. 2021 Dec; 36(1):497-503. doi: 10.1080/14756366.2021.1873977. [PMID: 33491508]
  • Qingxin Song, Shanxin Peng, Xiaosong Zhu. Baicalein protects against MPP+/MPTP-induced neurotoxicity by ameliorating oxidative stress in SH-SY5Y cells and mouse model of Parkinson's disease. Neurotoxicology. 2021 12; 87(?):188-194. doi: 10.1016/j.neuro.2021.10.003. [PMID: 34666128]
  • Justyna Chanaj-Kaczmarek, Tomasz Osmałek, Emilia Szymańska, Katarzyna Winnicka, Tomasz M Karpiński, Magdalena Dyba, Marta Bekalarska-Dębek, Judyta Cielecka-Piontek. Development and Evaluation of Thermosensitive Hydrogels with Binary Mixture of Scutellariae baicalensis radix Extract and Chitosan for Periodontal Diseases Treatment. International journal of molecular sciences. 2021 Oct; 22(21):. doi: 10.3390/ijms222111319. [PMID: 34768748]
  • Jiajia Mou, Shuang Qiu, Danghui Chen, Yanru Deng, Teka Tekleab. Design, synthesis, and primary activity assays of baicalein derivatives as cyclin-dependent kinase 1 inhibitors. Chemical biology & drug design. 2021 10; 98(4):639-654. doi: 10.1111/cbdd.13917. [PMID: 34233076]
  • Yan Xing, Xinxiu Ren, Xia Li, Liping Sui, Xuan Shi, Yu Sun, Chunshan Quan, Zhilong Xiu, Yuesheng Dong. Baicalein Enhances the Effect of Acarbose on the Improvement of Nonalcoholic Fatty Liver Disease Associated with Prediabetes via the Inhibition of De Novo Lipogenesis. Journal of agricultural and food chemistry. 2021 Sep; 69(34):9822-9836. doi: 10.1021/acs.jafc.1c04194. [PMID: 34406004]
  • Lijun Li, Hongzhi Gao, Kun Lou, Hongmei Luo, Sheng Hao, Jing Yuan, Zeyuan Liu, Ruihua Dong. Safety, tolerability, and pharmacokinetics of oral baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled multiple-ascending-dose study. Clinical and translational science. 2021 09; 14(5):2017-2024. doi: 10.1111/cts.13063. [PMID: 34156161]
  • Tomasz Tronina, Monika Mrozowska, Agnieszka Bartmańska, Jarosław Popłoński, Sandra Sordon, Ewa Huszcza. Simple and Rapid Method for Wogonin Preparation and Its Biotransformation. International journal of molecular sciences. 2021 Aug; 22(16):. doi: 10.3390/ijms22168973. [PMID: 34445678]
  • Huilong Xiang, Huan Lei, Ziyuan Liu, Yongjie Liu, Yang Li, Yinsheng Qiu, Lingyun Xu. Network pharmacology and molecular docking analysis on molecular targets: Mechanisms of baicalin and baicalein against hyperuricemic nephropathy. Toxicology and applied pharmacology. 2021 08; 424(?):115594. doi: 10.1016/j.taap.2021.115594. [PMID: 34044073]
  • Wenlong Sun, Panpan Liu, Bendong Yang, Meng Wang, Tianqi Wang, Wenbo Sun, Xudong Wang, Weilong Zheng, Xinhua Song, Jingda Li. A network pharmacology approach: Inhibition of the NF-κB signaling pathway contributes to the NASH preventative effect of an Oroxylum indicum seed extract in oleic acid-stimulated HepG2 cells and high-fat diet-fed rats. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jul; 88(?):153498. doi: 10.1016/j.phymed.2021.153498. [PMID: 33640247]
  • Li Gao, Wen-Ge Zheng, Xing-Kang Wu, Guan-Hua Du, Xue-Mei Qin. Baicalein Delays H2O2-Induced Astrocytic Senescence through Inhibition of Senescence-Associated Secretory Phenotype (SASP), Suppression of JAK2/STAT1/NF-κB Pathway, and Regulation of Leucine Metabolism. ACS chemical neuroscience. 2021 07; 12(13):2320-2335. doi: 10.1021/acschemneuro.1c00024. [PMID: 34152720]
  • Meng Yang, Xiangyu Li, Huijie Li, Xiaxia Zhang, Xiaolu Liu, Yeqiang Song. Baicalein inhibits RLS3-induced ferroptosis in melanocytes. Biochemical and biophysical research communications. 2021 07; 561(?):65-72. doi: 10.1016/j.bbrc.2021.05.010. [PMID: 34015760]
  • Vafa Baradaran Rahimi, Vahid Reza Askari, Hossein Hosseinzadeh. Promising influences of Scutellaria baicalensis and its two active constituents, baicalin, and baicalein, against metabolic syndrome: A review. Phytotherapy research : PTR. 2021 Jul; 35(7):3558-3574. doi: 10.1002/ptr.7046. [PMID: 33590943]
  • Ruihua Dong, Lijun Li, Hongzhi Gao, Kun Lou, Hongmei Luo, Sheng Hao, Jing Yuan, Zeyuan Liu. Safety, tolerability, pharmacokinetics, and food effect of baicalein tablets in healthy Chinese subjects: A single-center, randomized, double-blind, placebo-controlled, single-dose phase I study. Journal of ethnopharmacology. 2021 Jun; 274(?):114052. doi: 10.1016/j.jep.2021.114052. [PMID: 33753147]
  • Bin Li, Kaizhe Chen, Niandong Qian, Ping Huang, Fangqiong Hu, Tao Ding, Xing Xu, Qi Zhou, Bo Chen, Lianfu Deng, Tianwen Ye, Lei Guo. Baicalein alleviates osteoarthritis by protecting subchondral bone, inhibiting angiogenesis and synovial proliferation. Journal of cellular and molecular medicine. 2021 06; 25(11):5283-5294. doi: 10.1111/jcmm.16538. [PMID: 33939310]
  • Dongni Ji, Jianhua Li, Fanglin Xu, Yuhong Ren, Yong Wang. Improve the Biosynthesis of Baicalein and Scutellarein via Manufacturing Self-Assembly Enzyme Reactor In Vivo. ACS synthetic biology. 2021 05; 10(5):1087-1094. doi: 10.1021/acssynbio.0c00606. [PMID: 33880917]
  • X H Zhu, P Jiang, C J Yao, L Y Zhang. [Protective effect of baicalein on high fat-induced hepatocytes oxidative damage]. Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology. 2021 May; 29(5):462-467. doi: 10.3760/cma.j.cn501113-20190520-00176. [PMID: 34107585]
  • Guangjiao You, Tao Feng, Guoqin Zhang, Meiling Chen, Fan Liu, Lili Sun, Meng Wang, Xiaoliang Ren. Preparation, optimization, characterization and in vitro release of baicalein-solubilizing glycyrrhizic acid nano-micelles. International journal of pharmaceutics. 2021 May; 601(?):120546. doi: 10.1016/j.ijpharm.2021.120546. [PMID: 33794322]
  • Hui Jiang, Jian Liu, Yanling Wang, Leijing Chen, Hui Liu, Zhen Wang, Bin Wang. Screening the Q-markers of TCMs from RA rat plasma using UHPLC-QTOF/MS technique for the comprehensive evaluation of Wu-Wei-Wen-Tong Capsule. Journal of mass spectrometry : JMS. 2021 May; 56(5):e4711. doi: 10.1002/jms.4711. [PMID: 33764633]
  • Y H Luo, L Zhang, M Y Wang, J Fang, J Y Xia, X L Yu. Anti-cancer effects of baicalein on cervical carcinoma cells through down-regulation of the ERK/p38/MAPK pathway. Journal of biological regulators and homeostatic agents. 2021 May; 35(3):945-952. doi: 10.23812/21-52-a. [PMID: 34060266]
  • Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar, Vikas Jaitak. Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European journal of medicinal chemistry. 2021 Mar; 213(?):113037. doi: 10.1016/j.ejmech.2020.113037. [PMID: 33257172]
  • Harsh A Joshi, Raghavendra S Patwardhan, Deepak Sharma, Santosh K Sandur, Padma V Devarajan. Pre-clinical evaluation of an innovative oral nano-formulation of baicalein for modulation of radiation responses. International journal of pharmaceutics. 2021 Feb; 595(?):120181. doi: 10.1016/j.ijpharm.2020.120181. [PMID: 33359537]
  • Pooja M, Gangavaram Jyothi Reddy, Kanipakam Hema, Sujatha Dodoala, Bharathi Koganti. Unravelling high-affinity binding compounds towards transmembrane protease serine 2 enzyme in treating SARS-CoV-2 infection using molecular modelling and docking studies. European journal of pharmacology. 2021 Jan; 890(?):173688. doi: 10.1016/j.ejphar.2020.173688. [PMID: 33130280]
  • Hui Bai, Rui Yuan, Zhiheng Zhang, Lin Liu, Xinyu Wang, Xiaopeng Song, Tianwen Ma, Jilang Tang, Chunpeng Liu, Li Gao. Intra-articular Injection of Baicalein Inhibits Cartilage Catabolism and NLRP3 Inflammasome Signaling in a Posttraumatic OA Model. Oxidative medicine and cellular longevity. 2021; 2021(?):6116890. doi: 10.1155/2021/6116890. [PMID: 34512868]
  • Yasuko Yoshioka, Yayoi Kamata, Mitsutoshi Tominaga, Yoshie Umehara, Ikuyo Yoshida, Nobuya Matsuoka, Kenji Takamori. Extract of Scutellaria baicalensis induces semaphorin 3A production in human epidermal keratinocytes. PloS one. 2021; 16(4):e0250663. doi: 10.1371/journal.pone.0250663. [PMID: 33905439]
  • Jingyun Jin, Bin Chen, Xiangyang Zhan, Zhiyi Zhou, Hui Liu, Yun Dong. Network pharmacology and molecular docking study on the mechanism of colorectal cancer treatment using Xiao-Chai-Hu-Tang. PloS one. 2021; 16(6):e0252508. doi: 10.1371/journal.pone.0252508. [PMID: 34125845]
  • Yanyu Chen, Zean Zhao, Yongmei Li, Yang Yang, Lu Li, Yu Jiang, Cuiting Lin, Ying Cao, Pingzheng Zhou, Yuanxin Tian, Ting Wu, Jianxin Pang. Baicalein alleviates hyperuricemia by promoting uric acid excretion and inhibiting xanthine oxidase. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jan; 80(?):153374. doi: 10.1016/j.phymed.2020.153374. [PMID: 33075645]
  • Junke Song, Li Zhang, Yanfeng Xu, Dezhi Yang, Li Zhang, Shiying Yang, Wen Zhang, Jinhua Wang, Shuo Tian, Shengqian Yang, Tianyi Yuan, Ailin Liu, Qi Lv, Fengdi Li, Hongqi Liu, Biyu Hou, Xiaozhong Peng, Yang Lu, Guanhua Du. The comprehensive study on the therapeutic effects of baicalein for the treatment of COVID-19 in vivo and in vitro. Biochemical pharmacology. 2021 01; 183(?):114302. doi: 10.1016/j.bcp.2020.114302. [PMID: 33121927]
  • Estelle Palierse, Christophe Hélary, Jean-Marc Krafft, Isabelle Génois, Sylvie Masse, Guillaume Laurent, Maria I Alvarez Echazu, Mohamed Selmane, Sandra Casale, Laetitia Valentin, Antoine Miche, Ben C L Chan, Clara B S Lau, Margaret Ip, Martin F Desimone, Thibaud Coradin, Claude Jolivalt. Baicalein-modified hydroxyapatite nanoparticles and coatings with antibacterial and antioxidant properties. Materials science & engineering. C, Materials for biological applications. 2021 Jan; 118(?):111537. doi: 10.1016/j.msec.2020.111537. [PMID: 33255090]
  • Ting Xiao, Yulong Cui, Heyu Ji, Lulu Yan, Dongjie Pei, Shuangquan Qu. Baicalein attenuates acute liver injury by blocking NLRP3 inflammasome. Biochemical and biophysical research communications. 2021 01; 534(?):212-218. doi: 10.1016/j.bbrc.2020.11.109. [PMID: 33272570]
  • Li Zhang, Shili Yang, Lizhen Huang, Paul Chi-Lui Ho. Poly (ethylene glycol)-block-poly (D, L-lactide) (PEG-PLA) micelles for brain delivery of baicalein through nasal route for potential treatment of neurodegenerative diseases due to oxidative stress and inflammation: An in vitro and in vivo study. International journal of pharmaceutics. 2020 Dec; 591(?):119981. doi: 10.1016/j.ijpharm.2020.119981. [PMID: 33069896]
  • Nik Nur Hakimah Nik Salleh, Farah Amna Othman, Nur Alisa Kamarudin, Suat Cheng Tan. The Biological Activities and Therapeutic Potentials of Baicalein Extracted from Oroxylum indicum: A Systematic Review. Molecules (Basel, Switzerland). 2020 Dec; 25(23):. doi: 10.3390/molecules25235677. [PMID: 33276419]
  • Meifang Wang, Yinping Dong, Jing Wu, Hongyan Li, Yuanyang Zhang, Saijun Fan, Deguan Li. Baicalein ameliorates ionizing radiation-induced injuries by rebalancing gut microbiota and inhibiting apoptosis. Life sciences. 2020 Nov; 261(?):118463. doi: 10.1016/j.lfs.2020.118463. [PMID: 32950576]