Costunolide (BioDeep_00000359835)

Main id: BioDeep_00000000469

 

natural product PANOMIX_OTCML-2023 Chemicals and Drugs Antitumor activity


代谢物信息卡片


NCGC00381718-02_C15H20O2_Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-

化学式: C15H20O2 (232.1463)
中文名称: 木烃香内酯, 木香烃内酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C/1=C\CC/C(=C/[C@@H]2[C@@H](CC1)C(=C)C(=O)O2)/C
InChI: InChI=1S/C15H20O2/c1-10-5-4-6-11(2)9-14-13(8-7-10)12(3)15(16)17-14/h5,9,13-14H,3-4,6-8H2,1-2H3/b10-5+,11-9+/t13-,14+/m0/s1

描述信息

Costunolide is a germacranolide with anthelminthic, antiparasitic and antiviral activities. It has a role as an anthelminthic drug, an antiinfective agent, an antineoplastic agent, an antiparasitic agent, an antiviral drug and a metabolite. It is a germacranolide and a heterobicyclic compound.
(+)-Costunolide is a natural product found in Magnolia garrettii, Critonia morifolia, and other organisms with data available.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
A germacranolide with anthelminthic, antiparasitic and antiviral activities.
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells[1][2][3].

同义名列表

29 个代谢物同义名

Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-; (3aS,6E,10E)-3-Methylene-6,10-dimethyl-2,3,3abeta,4,5,8,9,11aalpha-octahydrocyclodeca[b]furan-2-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one; (3aS,6E,10E,11aR)-3a,4,5,8,9,11a-Hexahydro-6,10-dimethyl-3-methylene-cyclodeca[b]furan-2(3H)-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2(3H)-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3,3a,4,5,8,9-hexahydrocyclodeca[b]furan-2(11aH)-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[b]furan-2-one; (E,E)-germacra-1(10),4,11(13)-trien-12-oic acid, 6-alpha-hydroxy-gamma-lactone; (10S,1R)-3,7-dimethyl-11-methylene-13-oxabicyclo[8.3.0]trideca-2,6-dien-12-one; (E,E)-6-alpha-Hydroxygermacra-1(10),4,11(13)-trien-12-oic acid gamma-lactone; Costunolide, >=97\\% (HPLC); Costunolide,(S); (+)-costunolide; isocostunolide; Costus lactone; Costunolide; melampolide; Costunlide; Costunolid; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylidene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one; (3aS,6E,10E,11aR)-6,10-dimethyl-3-methylene-3a,4,5,8,9,11a-hexahydrocyclodeca[d]furan-2-one; STOCK1N-49769; AIDS-059915; AIDS059915; 553-21-9; C09382; NCGC00381718-02_C15H20O2_Cyclodeca[b]furan-2(3H)-one, 3a,4,5,8,9,11a-hexahydro-6,10-dimethyl-3-methylene-, (3aS,6E,10E,11aR)-; Costunolide



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

302 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, ANXA5, BCL2, CASP3, CASP7, CASP9, MAPK14, MAPK8, NFE2L2, PIK3CA, PTGS2, STAT3, TP53
Peripheral membrane protein 3 ANXA5, GORASP1, PTGS2
Endoplasmic reticulum membrane 3 BCL2, HMOX1, PTGS2
Nucleus 13 AKT1, BCL2, CASP3, CASP7, CASP9, HMOX1, MAPK14, MAPK8, MPO, NFE2L2, PARP1, STAT3, TP53
cytosol 14 AKT1, ANXA5, BCL2, CASP3, CASP7, CASP9, HMOX1, MAPK14, MAPK8, NFE2L2, PARP1, PIK3CA, STAT3, TP53
nuclear body 1 PARP1
centrosome 2 NFE2L2, TP53
nucleoplasm 11 AKT1, CASP3, CASP7, HMOX1, MAPK14, MAPK8, MPO, NFE2L2, PARP1, STAT3, TP53
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 2 AKT1, TNF
Cytoplasmic side 2 GORASP1, HMOX1
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 GORASP1
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 2 GORASP1, NFE2L2
Golgi membrane 1 GORASP1
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 3 CASP7, NFE2L2, PARP1
Lysosome 1 MPO
plasma membrane 5 AKT1, NFE2L2, PIK3CA, STAT3, TNF
Membrane 6 AKT1, ANXA5, BCL2, HMOX1, PARP1, TP53
axon 2 CCK, MAPK8
caveola 1 PTGS2
extracellular exosome 2 ANXA5, MPO
endoplasmic reticulum 4 BCL2, HMOX1, PTGS2, TP53
extracellular space 6 CASP7, CCK, HMOX1, IL6, MPO, TNF
perinuclear region of cytoplasm 2 HMOX1, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP9, MAPK14, PARP1, TP53
protein-containing complex 6 AKT1, BCL2, CASP9, PARP1, PTGS2, TP53
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 2 CCK, IL6
extracellular region 6 ANXA5, CCK, IL6, MAPK14, MPO, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 PARP1, STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ANXA5, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 2 PARP1, TP53
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 ANXA5
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 MPO
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 4 NFE2L2, PARP1, STAT3, TP53
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Chromosome 1 PARP1
Secreted, extracellular space 1 CASP7
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 2 PARP1, TP53
nuclear envelope 1 PARP1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
phagocytic vesicle lumen 1 MPO
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 2 NFE2L2, PARP1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
site of DNA damage 1 PARP1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • María Ángeles Ávila-Gálvez, Daniela Marques, Inês Figueira, Katarina Cankar, Dirk Bosch, Maria Alexandra Brito, Cláudia Nunes Dos Santos. Costunolide and parthenolide: Novel blood-brain barrier permeable sesquiterpene lactones to improve barrier tightness. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Sep; 167(?):115413. doi: 10.1016/j.biopha.2023.115413. [PMID: 37683593]
  • Anil Bhushan, Dixhya Rani, Misbah Tabassum, Saajan Kumar, Prem N Gupta, Sumeet Gairola, Ajai P Gupta, Prasoon Gupta. HPLC-PDA Method for Quantification of Bioactive Compounds in Crude Extract and Fractions of Aucklandia costus Falc. and Cytotoxicity Studies against Cancer Cells. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124815. [PMID: 37375368]
  • Ravneet Kaur, Shivalika Pathania, Monika Kajal, Vasundhara Thakur, Jagdeep Kaur, Kashmir Singh. Integrated analysis of smRNAome, transcriptome, and degradome data to decipher microRNAs regulating costunolide biosynthesis in Saussurea lappa. Plant science : an international journal of experimental plant biology. 2023 Jun; 331(?):111689. doi: 10.1016/j.plantsci.2023.111689. [PMID: 36965630]
  • Zhiyuan Mao, Yang Liu, Xiaojing Lv, Yu Jiang, Qun Zhang, Li Yang, Hezhong Jiang, Renxiang Tan, Rui Tan. Inter-synergized neuroprotection of costunolide engineered bone marrow mesenchymal stem cells targeting system. International journal of pharmaceutics. 2023 May; 639(?):122823. doi: 10.1016/j.ijpharm.2023.122823. [PMID: 36921741]
  • Mehmet Enes Arslan, Hasan Türkez, Yasemin Sevim, Harun Selvitopi, Abdurrahim Kadi, Sena Öner, Adil Mardinoğlu. Costunolide and Parthenolide Ameliorate MPP+ Induced Apoptosis in the Cellular Parkinson's Disease Model. Cells. 2023 03; 12(7):. doi: 10.3390/cells12070992. [PMID: 37048065]
  • Zi-Ying Zhan, Zhi-Hong Zhang, Hong-Xu Yang, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Potential skin health promoting benefits of costunolide: a therapeutic strategy to improve skin inflammation in imiquimod-induced psoriasis. Food & function. 2023 Feb; ?(?):. doi: 10.1039/d2fo02545k. [PMID: 36786020]
  • Arman Beyraghdar Kashkooli, Aalt D J van Dijk, Harro Bouwmeester, Alexander van der Krol. Individual lipid transfer proteins from Tanacetum parthenium show different specificity for extracellular accumulation of sesquiterpenes. Plant molecular biology. 2023 Jan; 111(1-2):153-166. doi: 10.1007/s11103-022-01316-2. [PMID: 36255594]
  • Wenlong Wu, Hongjuan Huang, Jietian Su, Xiaopeng Yun, Yixiao Zhang, Shouhui Wei, Zhaofeng Huang, Chaoxian Zhang, Quanjiang Bai. Dynamics of germination stimulants dehydrocostus lactone and costunolide in the root exudates and extracts of sunflower. Plant signaling & behavior. 2022 12; 17(1):2025669. doi: 10.1080/15592324.2022.2025669. [PMID: 35060434]
  • Wen Xing, Chaoling Wen, Deguo Wang, Hui Shao, Chunhong Liu, Chunling He, Opeyemi Joshua Olatunji. Cardiorenal Protective Effect of Costunolide against Doxorubicin-Induced Toxicity in Rats by Modulating Oxidative Stress, Inflammation and Apoptosis. Molecules (Basel, Switzerland). 2022 Mar; 27(7):. doi: 10.3390/molecules27072122. [PMID: 35408518]
  • Jingxin Mao, Honghong Zhan, Fancheng Meng, Guowei Wang, Dan Huang, Zhihua Liao, Min Chen. Costunolide protects against alcohol-induced liver injury by regulating gut microbiota, oxidative stress and attenuating inflammation in vivo and in vitro. Phytotherapy research : PTR. 2022 Mar; 36(3):1268-1283. doi: 10.1002/ptr.7383. [PMID: 35084790]
  • FanCheng Meng, Wei Zong, XiaoDong Wei, YunYi Tao, GuoWei Wang, ZhiHua Liao, Min Chen. Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Jul; 87(?):153588. doi: 10.1016/j.phymed.2021.153588. [PMID: 34091148]
  • InWha Park, Hee Sun Byun, Gang Min Hur, MinKyun Na. Tulipiferamide A, an Alkamide from Liriodendron tulipifera, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation. Journal of natural products. 2021 05; 84(5):1598-1606. doi: 10.1021/acs.jnatprod.1c00146. [PMID: 33939429]
  • Zi-Wei Yu, Yu Xie, Ze-Cheng Huang, Ke Yang, Zhan-Guo Wang, Hui-Ling Hu. Study of the therapeutic effect of raw and processed Vladimiriae Radix on ulcerative colitis based on intestinal flora, metabolomics and tissue distribution analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 May; 85(?):153538. doi: 10.1016/j.phymed.2021.153538. [PMID: 33765553]
  • Vasundhara Thakur, Savita Bains, Ravneet Kaur, Kashmir Singh. Identification and characterization of SlbHLH, SlDof and SlWRKY transcription factors interacting with SlDPD gene involved in costunolide biosynthesis in Saussurea lappa. International journal of biological macromolecules. 2021 Mar; 173(?):146-159. doi: 10.1016/j.ijbiomac.2021.01.114. [PMID: 33482203]
  • Sawalee Saosathan, Jalernsri Khounvong, Methee Rungrojsakul, Trinnakorn Katekunlaphan, Singkome Tima, Sawitree Chiampanichayakul, Cory Berkland, Songyot Anuchapreeda. Costunolide and parthenolide from Champi Sirindhorn (Magnolia sirindhorniae) inhibit leukemic cell proliferation in K562 and molt-4 cell lines. Natural product research. 2021 Mar; 35(6):988-992. doi: 10.1080/14786419.2019.1610752. [PMID: 31135208]
  • Shinya Okubo, Tomoe Ohta, Hideaki Fujita, Yukihiro Shoyama, Takuhiro Uto. Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells. Journal of natural medicines. 2021 Jan; 75(1):240-245. doi: 10.1007/s11418-020-01462-1. [PMID: 33159250]
  • Maximilian Frey, Iris Klaiber, Jürgen Conrad, Otmar Spring. CYP71BL9, the missing link in costunolide synthesis of sunflower. Phytochemistry. 2020 Sep; 177(?):112430. doi: 10.1016/j.phytochem.2020.112430. [PMID: 32516579]
  • Fan Xie, Hai Zhang, Chuan Zheng, Xiao-Fei Shen. Costunolide improved dextran sulfate sodium-induced acute ulcerative colitis in mice through NF-κB, STAT1/3, and Akt signaling pathways. International immunopharmacology. 2020 Jul; 84(?):106567. doi: 10.1016/j.intimp.2020.106567. [PMID: 32413737]
  • Otmar Spring, Katharina Schmauder, Nathalie D Lackus, Jasmin Schreiner, Carolin Meier, Jan Wellhausen, Lisa V Smith, Maximilian Frey. Spatial and developmental synthesis of endogenous sesquiterpene lactones supports function in growth regulation of sunflower. Planta. 2020 Jun; 252(1):2. doi: 10.1007/s00425-020-03409-y. [PMID: 32504343]
  • Qijuan Li, Zhanguo Wang, Yu Xie, Huiling Hu. Antitumor activity and mechanism of costunolide and dehydrocostus lactone: Two natural sesquiterpene lactones from the Asteraceae family. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):109955. doi: 10.1016/j.biopha.2020.109955. [PMID: 32014691]
  • Vasundhara Thakur, Savita Bains, Shivalika Pathania, Shailesh Sharma, Ravneet Kaur, Kashmir Singh. Comparative transcriptomics reveals candidate transcription factors involved in costunolide biosynthesis in medicinal plant-Saussurea lappa. International journal of biological macromolecules. 2020 May; 150(?):52-67. doi: 10.1016/j.ijbiomac.2020.01.312. [PMID: 32035965]
  • Trinh-Don Nguyen, Moonhyuk Kwon, Soo-Un Kim, Conrad Fischer, Dae-Kyun Ro. Catalytic Plasticity of Germacrene A Oxidase Underlies Sesquiterpene Lactone Diversification. Plant physiology. 2019 11; 181(3):945-960. doi: 10.1104/pp.19.00629. [PMID: 31534022]
  • Maximilian Frey, Iris Klaiber, Jürgen Conrad, Aylin Bersch, Irini Pateraki, Dae-Kyun Ro, Otmar Spring. Characterization of CYP71AX36 from Sunflower (Helianthus annuus L., Asteraceae). Scientific reports. 2019 10; 9(1):14295. doi: 10.1038/s41598-019-50520-6. [PMID: 31586110]
  • Zhanpeng Yan, Tingting Xu, Zhentao An, Ying Hu, Wanzhen Chen, Jinxia Ma, Changle Shao, Fangshi Zhu. Costunolide induces mitochondria-mediated apoptosis in human gastric adenocarcinoma BGC-823 cells. BMC complementary and alternative medicine. 2019 Jun; 19(1):151. doi: 10.1186/s12906-019-2569-6. [PMID: 31242894]
  • Yichen Fang, Jie Li, Yinan Wu, Jing Gui, Yang Shen. Costunolide Inhibits the Growth of OAW42-A Multidrug-Resistant Human Ovarian Cancer Cells by Activating Apoptotic and Autophagic Pathways, Production of Reactive Oxygen Species (ROS), Cleaved Caspase-3 and Cleaved Caspase-9. Medical science monitor : international medical journal of experimental and clinical research. 2019 05; 25(?):3231-3237. doi: 10.12659/msm.914029. [PMID: 31043579]
  • Eti Mehrotra, Jyotsna Vishwakarma, Avinash C Tripathi, Pankaj K Sonar, Shailendra K Saraf. Schizonticidal antimalarial sesquiterpene lactones from Magnolia champaca (L.) Baill. ex Pierre: microwave-assisted extraction, HPTLC fingerprinting and computational studies. Natural product research. 2019 Feb; 33(4):568-572. doi: 10.1080/14786419.2017.1396595. [PMID: 29086620]
  • Qing Liu, Arman Beyraghdar Kashkooli, David Manzano, Irini Pateraki, Lea Richard, Pim Kolkman, Maria Fátima Lucas, Victor Guallar, Ric C H de Vos, Maurice C R Franssen, Alexander van der Krol, Harro Bouwmeester. Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity. Nature communications. 2018 11; 9(1):4657. doi: 10.1038/s41467-018-06565-8. [PMID: 30405138]
  • Shu Dong, Li-Yan Ma, Yue-Tao Liu, Meng Yu, Hong-Mei Jia, Hong-Wu Zhang, Chang-Yuan Yu, Zhong-Mei Zou. Pharmacokinetics of costunolide and dehydrocostuslactone after oral administration of Radix aucklandiae extract in normal and gastric ulcer rats. Journal of Asian natural products research. 2018 Nov; 20(11):1055-1063. doi: 10.1080/10286020.2018.1489379. [PMID: 30130142]
  • Jingkun Liu, Min Xie, Xiuzhuang Li, Hui Jin, Xiaoyan Yang, Zhiqiang Yan, Anxiang Su, Bo Qin. Main Allelochemicals from the Rhizosphere Soil of Saussurea lappa (Decne.) Sch. Bip. and Their Effects on Plants' Antioxidase Systems. Molecules (Basel, Switzerland). 2018 Sep; 23(10):. doi: 10.3390/molecules23102506. [PMID: 30274332]
  • Bo-Kyung Lee, Soo-Jin Park, So-Yeon Nam, Saeromi Kang, Jin Hwang, Seung-Jin Lee, Dong-Soon Im. Anti-allergic effects of sesquiterpene lactones from Saussurea costus (Falc.) Lipsch. determined using in vivo and in vitro experiments. Journal of ethnopharmacology. 2018 Mar; 213(?):256-261. doi: 10.1016/j.jep.2017.11.018. [PMID: 29158156]
  • Siwattra Choodej, Khanitha Pudhom, Tohru Mitsunaga. Inhibition of TNF-α-Induced Inflammation by Sesquiterpene Lactones from Saussurea lappa and Semi-Synthetic Analogues. Planta medica. 2018 Mar; 84(5):329-335. doi: 10.1055/s-0043-120115. [PMID: 28962049]
  • Njogu M Kimani, Josphat C Matasyoh, Marcel Kaiser, Reto Brun, Thomas J Schmidt. Antiprotozoal Sesquiterpene Lactones and Other Constituents from Tarchonanthus camphoratus and Schkuhria pinnata. Journal of natural products. 2018 01; 81(1):124-130. doi: 10.1021/acs.jnatprod.7b00747. [PMID: 29244495]
  • Yanan Wang, Xu Zhang, Lilei Zhao, Mingyu Shi, Zhengkai Wei, Zhengtao Yang, Changming Guo, Yunhe Fu. Costunolide protects lipopolysaccharide/d-galactosamine-induced acute liver injury in mice by inhibiting NF-κB signaling pathway. The Journal of surgical research. 2017 12; 220(?):40-45. doi: 10.1016/j.jss.2017.06.083. [PMID: 29180209]
  • Antonio Cala, José M G Molinillo, Mónica Fernández-Aparicio, Jesús Ayuso, José A Álvarez, Diego Rubiales, Francisco A Macías. Complexation of sesquiterpene lactones with cyclodextrins: synthesis and effects on their activities on parasitic weeds. Organic & biomolecular chemistry. 2017 Aug; 15(31):6500-6510. doi: 10.1039/c7ob01394a. [PMID: 28745382]
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