Astragaloside (BioDeep_00000000353)

   

PANOMIX_OTCML-2023


代谢物信息卡片


[(2S,3R,4S,5R)-4,5-dihydroxy-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-9-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]oxan-3-yl] acetate

化学式: C43H70O15 (826.4714)
中文名称: 黄芪皂苷 II, 黄芪皂苷-Ⅱ, 黄芪皂苷II
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 96.97%

分子结构信息

SMILES: CC(=O)OC1C(C(COC1OC2CCC34CC35CCC6(C(C(CC6(C5CC(C4C2(C)C)OC7C(C(C(C(O7)CO)O)O)O)C)O)C8(CCC(O8)C(C)(C)O)C)C)O)O
InChI: InChI=1S/C43H70O15/c1-20(45)54-32-28(48)22(47)18-53-36(32)57-26-10-12-43-19-42(43)14-13-39(6)33(41(8)11-9-27(58-41)38(4,5)52)21(46)16-40(39,7)25(42)15-23(34(43)37(26,2)3)55-35-31(51)30(50)29(49)24(17-44)56-35/h21-36,44,46-52H,9-19H2,1-8H3/t21-,22+,23-,24+,25-,26-,27-,28-,29+,30-,31+,32+,33-,34-,35+,36-,39+,40-,41+,42-,43+/m0/s1

描述信息

Astragaloside II is a triterpenoid saponin that is cycloastragenol glycosylated at positions 3 and 6 by 2-O-acetyl-beta-D-xylosyl and beta-D-glucosyl residues respectively. It has a role as a plant metabolite. It is a beta-D-glucoside, a monosaccharide derivative, a member of oxolanes, a pentacyclic triterpenoid and a triterpenoid saponin. It is functionally related to a cycloastragenol.
Astragaloside II is a natural product found in Euphorbia glareosa, Astragalus hoantchy, and other organisms with data available.
See also: Astragalus propinquus root (part of).
A triterpenoid saponin that is cycloastragenol glycosylated at positions 3 and 6 by 2-O-acetyl-beta-D-xylosyl and beta-D-glucosyl residues respectively.
Astragaloside II is a natural compound isolated from Astragalus membranaceus.
Astragaloside II is a natural compound isolated from Astragalus membranaceus.

同义名列表

15 个代谢物同义名

[(2S,3R,4S,5R)-4,5-dihydroxy-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-9-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-6-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]oxan-3-yl] acetate; (3beta,6alpha,9beta,16beta,20R,24S)-3-[(2-O-acetyl-beta-D-xylopyranosyl)oxy]-16,25-dihydroxy-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside; (3beta,6alpha,9beta,16beta,20R,24S)-3-((2-O-acetyl-beta-D-xylopyranosyl)oxy)-16,25-dihydroxy-20,24-epoxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside; beta-D-Glucopyranoside, (3beta,6alpha,16beta,20R,24S)-3-[(2-O-acetyl-beta-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl-; (3beta,6alpha,16beta,20R,24S)-3-[(2-O-Acetyl-beta-D-xylopyranosyl)oxy]-20,24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl beta-D-glucopyranoside; Astragaloside II (constituent of astragalus) [DSC]; Astragaloside II (constituent of astragalus); Astragaloside II, >=92\\% (HPLC); Astrasieversianin VIII; Astragaloside II; Astragaloside-Ⅱ; AstragalosideII; Astragaloside; 0K5J34DHEN; Astragaloside II



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AIMP2, ALB, CCND1, DCTN4, EIF4EBP1, KEAP1, MTOR, NOX4, PINK1
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 3 HSD17B7, MTOR, NOX4
Nucleus 12 ACR, AIMP2, ALB, CCND1, DCTN4, EIF4EBP1, GABPA, KEAP1, MTOR, NOX4, PCNA, PINK1
autophagosome 1 MAP1LC3A
cytosol 11 AIMP2, ALB, CCND1, DCTN4, EIF4EBP1, FIS1, KEAP1, MAP1LC3A, MFN2, MTOR, PINK1
dendrite 1 MTOR
nuclear body 1 PCNA
phagocytic vesicle 1 MTOR
centrosome 4 ALB, CCND1, DCTN4, PCNA
nucleoplasm 5 CCND1, GABPA, KEAP1, MTOR, PCNA
Cell membrane 2 NOX1, NOX4
Lipid-anchor 1 MAP1LC3A
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 3 MFN2, NOX1, NOX4
Golgi apparatus membrane 1 MTOR
cell cortex 1 DCTN4
glutamatergic synapse 1 MAP1LC3A
Golgi apparatus 1 ALB
Golgi membrane 1 MTOR
growth cone 1 PINK1
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 PINK1
Cytoplasm, cytosol 2 AIMP2, PINK1
Lysosome 1 MTOR
plasma membrane 2 NOX1, NOX4
Membrane 6 AIMP2, FIS1, MTOR, NOX1, NOX4, PINK1
axon 2 CCK, PINK1
extracellular exosome 2 ALB, PCNA
Lysosome membrane 1 MTOR
endoplasmic reticulum 4 ALB, KEAP1, NOX4, PINK1
extracellular space 3 ALB, CCK, IL6
perinuclear region of cytoplasm 2 NOX4, PINK1
bicellular tight junction 1 CCND1
mitochondrion 5 FIS1, HSD17B7, MFN2, NOX4, PINK1
protein-containing complex 3 ACR, ALB, FIS1
intracellular membrane-bounded organelle 1 MAP1LC3A
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 ALB, CCK, IL6
extracellular region 4 ACR, ALB, CCK, IL6
Mitochondrion outer membrane 4 FIS1, MFN2, MTOR, PINK1
Single-pass membrane protein 3 FIS1, HSD17B7, PINK1
mitochondrial outer membrane 4 FIS1, MFN2, MTOR, PINK1
anchoring junction 2 ALB, NOX1
centriolar satellite 1 KEAP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 DCTN4
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
microtubule cytoskeleton 1 MFN2
nucleolus 1 NOX4
midbody 1 KEAP1
Early endosome 1 NOX1
Golgi-associated vesicle 1 ACR
Cytoplasm, perinuclear region 1 NOX4
Mitochondrion inner membrane 1 PINK1
Cell junction, focal adhesion 1 NOX4
Cytoplasm, cytoskeleton 2 DCTN4, MAP1LC3A
focal adhesion 2 DCTN4, NOX4
microtubule 1 MAP1LC3A
Peroxisome 1 FIS1
peroxisomal membrane 1 FIS1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
mitochondrial intermembrane space 1 PINK1
Cytoplasm, myofibril, sarcomere 1 DCTN4
Late endosome 1 MAP1LC3A
sarcomere 1 DCTN4
ciliary basal body 1 ALB
chromatin 3 GABPA, PCNA, PINK1
Cytoplasmic vesicle, autophagosome membrane 1 MAP1LC3A
autophagosome membrane 1 MAP1LC3A
cell projection 1 NOX1
cytoskeleton 1 PINK1
centriole 1 ALB
[Isoform 5]: Cytoplasm 1 NOX4
Nucleus, nucleolus 1 NOX4
spindle pole 2 ALB, DCTN4
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Cytoplasm, cell cortex 1 DCTN4
actin filament 1 KEAP1
blood microparticle 1 ALB
organelle membrane 1 MAP1LC3A
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 1 MTOR
Endomembrane system 2 MAP1LC3A, MTOR
cell body 1 PINK1
replication fork 1 PCNA
Peroxisome membrane 1 FIS1
stress fiber 1 DCTN4
[Isoform 3]: Cytoplasm 1 NOX4
endoplasmic reticulum lumen 2 ALB, IL6
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 ALB
dynactin complex 1 DCTN4
kinetochore 1 DCTN4
cytoplasmic dynein complex 1 DCTN4
perinuclear endoplasmic reticulum 1 NOX4
nuclear lamina 1 PCNA
Cytoplasm, cytoskeleton, stress fiber 1 DCTN4
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Lewy body 1 PINK1
Cytoplasmic vesicle, phagosome 1 MTOR
[Isoform 4]: Nucleus 1 NOX4
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
astrocyte projection 1 PINK1
Autolysosome 1 MAP1LC3A
inclusion body 1 KEAP1
NADPH oxidase complex 2 NOX1, NOX4
interleukin-6 receptor complex 1 IL6
Cell projection, invadopodium membrane 1 NOX1
acrosomal matrix 1 ACR
[Isoform 6]: Cytoplasm 1 NOX4
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
cyclin D1-CDK6 complex 1 CCND1
ciliary transition fiber 1 ALB


文献列表

  • Lijia Zhang, Ye Liu, Xue Lei, Xiaowai Liu, Heng Sun, Songjiang Liu. Astragaloside II enhanced sensitivity of ovarian cancer cells to cisplatin via triggering apoptosis and autophagy. Cell biology international. 2023 Jun; ?(?):. doi: 10.1002/cbin.12055. [PMID: 37323083]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Xue Li, Zifeng Pi, Shu Liu, Wei Wang, Zhiqiang Liu, Fengrui Song. Online monitoring of astragaloside II metabolism using a homemade cultural device coupled with microdialysis and ultra-performance liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Sep; 1063(?):141-148. doi: 10.1016/j.jchromb.2017.08.012. [PMID: 28865330]
  • Yanhong Wang, Yang Li, Yan Zhang, Guan Feng, Zhixin Yang, Qingxia Guan, Rui Wang, Fengjuan Han. Multi-Dimensional Spectrum-Effect Relationship of the Impact of Chinese Herbal Formula Lichong Shengsui Yin on Ovarian Cancer. Molecules (Basel, Switzerland). 2017 Jun; 22(6):. doi: 10.3390/molecules22060979. [PMID: 28608834]
  • Cui Yang, Chao Wu, Dujuan Xu, Meng Wang, Quan Xia. AstragalosideII inhibits autophagic flux and enhance chemosensitivity of cisplatin in human cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2016 Jul; 81(?):166-175. doi: 10.1016/j.biopha.2016.03.025. [PMID: 27261591]
  • Fei-fei Ding, Yan-ru Deng, Xiao-jing Zhang, Yi Sun, Li-ping Guo. [Simultaneous Determination of Five Astragalosides in Astragali Radix and Jinqi Jiangtang Tablet by HPLC-ELSD]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jan; 38(1):156-9. doi: . [PMID: 26214884]
  • Xiao-hua Liu, Jian-bang Zhao, Long Guo, Ying-lai Yang, Fang Hu, Rui-juan Zhu, Shi-lan Feng. Simultaneous determination of calycosin-7-O-β-D-glucoside, ononin, calycosin, formononetin, astragaloside IV, and astragaloside II in rat plasma after oral administration of Radix Astragali extraction for their pharmacokinetic studies by ultra-pressure liquid chromatography with tandem mass spectrometry. Cell biochemistry and biophysics. 2014 Sep; 70(1):677-86. doi: 10.1007/s12013-014-9972-x. [PMID: 24782060]
  • Ha-Jeong Kwon, Jeehyun Hwang, Sun-Kyoung Lee, Yong-Duk Park. Astragaloside content in the periderm, cortex, and xylem of Astragalus membranaceus root. Journal of natural medicines. 2013 Oct; 67(4):850-5. doi: 10.1007/s11418-013-0741-8. [PMID: 23381847]
  • Lee-Hsin Shaw, Wei-Ming Chen, Tung-Hu Tsai. Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry. Molecules (Basel, Switzerland). 2013 Sep; 18(9):11281-98. doi: 10.3390/molecules180911281. [PMID: 24036516]
  • Chun-ping Wan, Li-xin Gao, Li-fei Hou, Xiao-qian Yang, Pei-lan He, Yi-fu Yang, Wei Tang, Jian-min Yue, Jia Li, Jian-ping Zuo. Astragaloside II triggers T cell activation through regulation of CD45 protein tyrosine phosphatase activity. Acta pharmacologica Sinica. 2013 Apr; 34(4):522-30. doi: 10.1038/aps.2012.208. [PMID: 23524573]
  • Can Huang, Dujuan Xu, Quan Xia, Peipei Wang, Chao Rong, Yong Su. Reversal of P-glycoprotein-mediated multidrug resistance of human hepatic cancer cells by Astragaloside II. The Journal of pharmacy and pharmacology. 2012 Dec; 64(12):1741-50. doi: 10.1111/j.2042-7158.2012.01549.x. [PMID: 23146037]
  • Meltem Ozipek, Ali A Dönmez, Ihsan Caliş, Reto Brun, Peter Rüedi, Deniz Tasdemir. Leishmanicidal cycloartane-type triterpene glycosides from Astragalus oleifolius. Phytochemistry. 2005 May; 66(10):1168-73. doi: 10.1016/j.phytochem.2005.04.019. [PMID: 15922377]