Neomycin (BioDeep_00000003472)

 

Secondary id: BioDeep_00001867660

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product Volatile Flavor Compounds


代谢物信息卡片


(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol

化学式: C23H46N6O13 (614.3122705999999)
中文名称: 新霉素B
谱图信息: 最多检出来源 Viridiplantae(plant) 0.17%

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
InChI: InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1

描述信息

A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed). Neomycin is a bactericidal aminoglycoside antibiotic that binds to the 30S ribosome of susceptible organisms. Binding interferes with mRNA binding and acceptor tRNA sites and results in the production of non-functional or toxic peptides.
A - Alimentary tract and metabolism > A01 - Stomatological preparations > A01A - Stomatological preparations > A01AB - Antiinfectives and antiseptics for local oral treatment
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07A - Intestinal antiinfectives > A07AA - Antibiotics
B - Blood and blood forming organs > B05 - Blood substitutes and perfusion solutions > B05C - Irrigating solutions > B05CA - Antiinfectives
D - Dermatologicals > D09 - Medicated dressings > D09A - Medicated dressings > D09AA - Medicated dressings with antiinfectives
D - Dermatologicals > D06 - Antibiotics and chemotherapeutics for dermatological use > D06A - Antibiotics for topical use
S - Sensory organs > S03 - Ophthalmological and otological preparations > S03A - Antiinfectives > S03AA - Antiinfectives
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations > R02AB - Antibiotics
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
S - Sensory organs > S02 - Otologicals > S02A - Antiinfectives > S02AA - Antiinfectives
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
KEIO_ID N022

同义名列表

28 个代谢物同义名

(2S,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-{[(2R,3S,4R,5S)-5-{[(1R,2R,3S,5R,6S)-3,5-diamino-2-{[(2R,3R,4R,5S,6R)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy}-6-hydroxycyclohexyl]oxy}-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl]oxy}oxane-3,4-diol; 4,6-Diamino-2-{[3-o-(2,6-diamino-2,6-dideoxyhexopyranosyl)pentofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxyhexopyranoside; Fradiomycin B;Neomycin B; Sulfate, fradiomycin; Palmitate, neomycin; Sulfate, neomycin b; Fradiomycin sulfate; Sulfate, framycetin; Framycetin sulfate; Neomycin palmitate; Neomycin b sulfate; Neomycin sulphate; Sulfate, neomycin; Antibiotic 10676; Neomycin sulfate; Caswell no. 595; Fradiomycin b; Framycetinum; Framicetina; Framycetine; USAF CB-19; Neomycin b; Framycetin; Soframycin; Neomycin; FRM; Neomycin; Neomycin B



数据库引用编号

35 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

119 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Junming Zhang, Jianhao Song, Haobo Li, Zhaoxia Li, Mengyu Chen, Shutao Ma, Rong Shen, Xiangxin Lou. Berberine protects against neomycin-induced ototoxicity by reducing ROS generation and activating the PI3K/AKT pathway. Neuroscience letters. 2023 Nov; 817(?):137518. doi: 10.1016/j.neulet.2023.137518. [PMID: 37844727]
  • Maria H C Santos, Valdenice F Santos, Priscilla R Freitas, Romério R S Silva, Renato Rodrigues Roma, Ana L E Santos, Daiany Alves Ribeiro, Henrique D M Coutinho, Bruno A M Rocha, Manoel M E Oliveira, Claudener S Teixeira. Dioclea violacea lectin increases the effect of neomycin against multidrug-resistant strains and promotes the purification of the antibiotic in immobilized lectin column. International journal of biological macromolecules. 2023 Mar; 236(?):123941. doi: 10.1016/j.ijbiomac.2023.123941. [PMID: 36893486]
  • Lingbing Zhang, Yandan Zhang, Xuejun Jiang, Lejiao Mao, Yinyin Xia, Yinzhen Fan, Na Li, Ziqi Jiang, Xia Qin, Yu Jiang, Gang Liu, Feng Qiu, Jun Zhang, Zhen Zou, Chengzhi Chen. Disruption of the lung-gut-brain axis is responsible for cortex damage induced by pulmonary exposure to zinc oxide nanoparticles. Toxicology. 2023 02; 485(?):153390. doi: 10.1016/j.tox.2022.153390. [PMID: 36535435]
  • Paula V Huertas-Abril, María-José Prieto-Álamo, Juan Jurado, Tamara García-Barrera, Nieves Abril. A selenium-enriched diet helps to recover liver function after antibiotic administration in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jan; 171(?):113519. doi: 10.1016/j.fct.2022.113519. [PMID: 36464106]
  • Mohammed Monirul Islam, Varshini Hemmanahalli Ramesh, Penmetsa Durga Bhavani, Prakash S Goudanavar, N Raghavendra Naveen, B Ramesh, Santosh Fattepur, Predeepkumar Narayanappa Shiroorkar, Mohammed Habeebuddin, Girish Meravanige, Mallikarjun Telsang, Nagaraja Sreeharsha. Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing. Drug delivery. 2022 Dec; 29(1):3370-3383. doi: 10.1080/10717544.2022.2144963. [PMID: 36404771]
  • Varsha Saini, Devashish Mehta, Siddhi Gupta, Sandeep Kumar, Parul Rani, Kajal Rana, Kajal Rajput, Dolly Jain, Garima Pal, Bharti Aggarwal, Sanjay Pal, Sonu K Gupta, Yashwant Kumar, Vemanna S Ramu, Avinash Bajaj. Targeting Vancomycin-Resistant Enterococci (VRE) Infections and Van Operon-Mediated Drug Resistance Using Dimeric Cholic Acid-Peptide Conjugates. Journal of medicinal chemistry. 2022 11; 65(22):15312-15326. doi: 10.1021/acs.jmedchem.2c01293. [PMID: 36331380]
  • Rikeshwer Prasad Dewangan, Devesh Pratap Verma, Neeraj Kumar Verma, Ankit Gupta, Garima Pant, Kalyan Mitra, Saman Habib, Jimut Kanti Ghosh. Spermine-Conjugated Short Proline-Rich Lipopeptides as Broad-Spectrum Intracellular Targeting Antibacterial Agents. Journal of medicinal chemistry. 2022 04; 65(7):5433-5448. doi: 10.1021/acs.jmedchem.1c01809. [PMID: 35297625]
  • Yi Zhang, Mufan Ji, Zhenyang Gu, Wenlong Pei, Jun Zhu, Qian Wu, Lei Li, Zhan Zhang. Elemicin exposure induced aberrant lipid metabolism via modulation of gut microbiota in mice. Toxicology. 2022 02; 467(?):153088. doi: 10.1016/j.tox.2021.153088. [PMID: 34979169]
  • Jieya Zhou, Ran Ping, Hao Wu, Hongbo Liu, Xuming Wang, AiLing Ren, Shulei Tian, Yingqun Ma. Recycling of neomycin fermentation residue using SEA-CBS technology: Growth performance and antibiotic resistance genes. The Science of the total environment. 2022 Feb; 807(Pt 1):150860. doi: 10.1016/j.scitotenv.2021.150860. [PMID: 34626630]
  • Shiyu Li, Yusong Jin, Wenyi Fu, Abigail D Cox, Dale Lee, Lavanya Reddivari. Intermittent antibiotic treatment accelerated the development of colitis in IL-10 knockout mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112486. doi: 10.1016/j.biopha.2021.112486. [PMID: 34891113]
  • Åke Stenholm, Mikael Hedeland, Curt E Pettersson. Neomycin removal using the white rot fungus Trametes versicolor. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2022; 57(6):436-447. doi: 10.1080/10934529.2022.2072644. [PMID: 35583106]
  • Juying Jiao, Jianjun Liu, Qi Li, Guixin Zhang, Chen Pan, Fei Luo, Qingkai Zhang, Bing Qi, Liang Zhao, Peiyuan Yin, Dong Shang. Gut Microbiota-Derived Diaminopimelic Acid Promotes the NOD1/RIP2 Signaling Pathway and Plays a Key Role in the Progression of Severe Acute Pancreatitis. Frontiers in cellular and infection microbiology. 2022; 12(?):838340. doi: 10.3389/fcimb.2022.838340. [PMID: 35811665]
  • Hobby Aggarwal, Priya Pathak, Yashwant Kumar, Kumaravelu Jagavelu, Madhu Dikshit. Modulation of Insulin Resistance, Dyslipidemia and Serum Metabolome in iNOS Knockout Mice following Treatment with Nitrite, Metformin, Pioglitazone, and a Combination of Ampicillin and Neomycin. International journal of molecular sciences. 2021 Dec; 23(1):. doi: 10.3390/ijms23010195. [PMID: 35008623]
  • R Ramessur, N Saffar, B Czako, A Agarwal, K Batta. Cutaneous thrombosis associated with skin necrosis following Oxford-AstraZeneca COVID-19 vaccination. Clinical and experimental dermatology. 2021 Dec; 46(8):1610-1612. doi: 10.1111/ced.14819. [PMID: 34189756]
  • Alberto Arezzo, Massimiliano Mistrangelo, Marco Augusto Bonino, Paola Salusso, Edoardo Forcignanò, Nereo Vettoretto, Emanuele Botteri, Nicola Cillara, Roberto Ottonello, Valentina Testa, Francesco Giuseppe De Rosa, Silvia Corcione, Roberto Passera, Mario Morino. Oral neomycin and bacitracin are effective in preventing surgical site infections in elective colorectal surgery: a multicentre, randomized, parallel, single-blinded trial (COLORAL-1). Updates in surgery. 2021 Oct; 73(5):1775-1786. doi: 10.1007/s13304-021-01112-5. [PMID: 34148172]
  • L N Buss, T T Yohe, L R Cangiano, D L Renaud, A J Keunen, L L Guan, M A Steele. The effect of neomycin inclusion in milk replacer on the health, growth, and performance of male Holstein calves during preweaning. Journal of dairy science. 2021 Jul; 104(7):8188-8201. doi: 10.3168/jds.2020-19827. [PMID: 33934860]
  • Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Journal of natural products. 2021 03; 84(3):750-761. doi: 10.1021/acs.jnatprod.0c00946. [PMID: 33226219]
  • Anton Kovacik, Eva Tvrda, Tomas Jambor, Diana Fulopova, Eva Kovacikova, Lukas Hleba, Łukasz M Kołodziejczyk, Miroslava Hlebova, Agnieszka Gren, Peter Massanyi. Cytotoxic effect of aminoglycoside antibiotics on the mammalian cell lines. Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering. 2021; 56(1):1-8. doi: 10.1080/10934529.2020.1830653. [PMID: 33040680]
  • A G Gomes Coutinho, E Pinheiro, R Fernandez. The calcium sensing receptor modulates H+-ATPase activity in intercalated cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2020 Dec; 71(6):. doi: 10.26402/jpp.2020.6.09. [PMID: 33901996]
  • Zhi Xu. 1,2,3-Triazole-containing hybrids with potential antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). European journal of medicinal chemistry. 2020 Nov; 206(?):112686. doi: 10.1016/j.ejmech.2020.112686. [PMID: 32795773]
  • Xavier de la Torre, Cristiana Colamonici, Michele Iannone, Daniel Jardines, Francesco Molaioni, Francesco Botrè. Detection of clostebol in sports: Accidental doping?. Drug testing and analysis. 2020 Nov; 12(11-12):1561-1569. doi: 10.1002/dta.2951. [PMID: 33119965]
  • Scott W Korte, Rebecca A Dorfmeyer, Craig L Franklin, Aaron C Ericsson. Acute and long-term effects of antibiotics commonly used in laboratory animal medicine on the fecal microbiota. Veterinary research. 2020 Sep; 51(1):116. doi: 10.1186/s13567-020-00839-0. [PMID: 32928304]
  • Man Zhao, Jianhua Chen, Huiqing Jin, Zhi Qi. Extracellular Ca2+ induces desensitized cytosolic Ca2+ rise sensitive to phospholipase C inhibitor which suppresses root growth with Ca2+ dependence. Journal of plant physiology. 2020 Sep; 252(?):153190. doi: 10.1016/j.jplph.2020.153190. [PMID: 32688165]
  • Monica Sánchez-Tapia, Daniela Moreno-Vicencio, Guillermo Ordáz-Nava, Martha Guevara-Cruz, Omar Granados-Portillo, Ariana Vargas-Castillo, Nimbe Torres, Armando R Tovar. Antibiotic Treatment Reduces the Health Benefits of Soy Protein. Molecular nutrition & food research. 2020 09; 64(17):e2000532. doi: 10.1002/mnfr.202000532. [PMID: 32729948]
  • Hamideh Hamidi, Mahshid Zarrineh, Ali Es-Haghi, Alireza Ghasempour. Rapid and sensitive determination of neomycin and kanamycin in measles, mumps, and rubella vaccine via high-performance liquid chromatography-tandem mass spectrometry using modified super-paramagnetic Fe3O4 nanospheres. Journal of chromatography. A. 2020 Aug; 1625(?):461343. doi: 10.1016/j.chroma.2020.461343. [PMID: 32709308]
  • Moriah Jospe-Kaufman, Liza Siomin, Micha Fridman. The relationship between the structure and toxicity of aminoglycoside antibiotics. Bioorganic & medicinal chemistry letters. 2020 07; 30(13):127218. doi: 10.1016/j.bmcl.2020.127218. [PMID: 32360102]
  • Andrew M Breglio, Lindsey A May, Melanie Barzik, Nora C Welsh, Shimon P Francis, Tucker Q Costain, Lizhen Wang, D Eric Anderson, Ronald S Petralia, Ya-Xian Wang, Thomas B Friedman, Matthew Ja Wood, Lisa L Cunningham. Exosomes mediate sensory hair cell protection in the inner ear. The Journal of clinical investigation. 2020 05; 130(5):2657-2672. doi: 10.1172/jci128867. [PMID: 32027617]
  • Xiaoxiao Liu, Yanzhuo Liu, Xuewei Chen, Chenlong Wang, Xuehan Chen, Wen Liu, Keqing Huang, Honglei Chen, Jing Yang. Multi-walled carbon nanotubes exacerbate doxorubicin-induced cardiotoxicity by altering gut microbiota and pulmonary and colonic macrophage phenotype in mice. Toxicology. 2020 04; 435(?):152410. doi: 10.1016/j.tox.2020.152410. [PMID: 32068018]
  • Michael A Malfatti, Edward A Kuhn, Deepa K Murugesh, Melanie E Mendez, Nicholas Hum, James B Thissen, Crystal J Jaing, Gabriela G Loots. Manipulation of the Gut Microbiome Alters Acetaminophen Biodisposition in Mice. Scientific reports. 2020 03; 10(1):4571. doi: 10.1038/s41598-020-60982-8. [PMID: 32165665]
  • Emilia R Dellacecca, Cormac Cosgrove, Zhussipbek Mukhatayev, Suhail Akhtar, Victor H Engelhard, Alfred W Rademaker, Katherine L Knight, I Caroline Le Poole. Antibiotics Drive Microbial Imbalance and Vitiligo Development in Mice. The Journal of investigative dermatology. 2020 03; 140(3):676-687.e6. doi: 10.1016/j.jid.2019.08.435. [PMID: 31472106]
  • Zhiwei Zheng, Dongmei Tang, Liping Zhao, Wen Li, Jinghong Han, Bing Hu, Guohui Nie, Yingzi He. Liproxstatin-1 Protects Hair Cell-Like HEI-OC1 Cells and Cochlear Hair Cells against Neomycin Ototoxicity. Oxidative medicine and cellular longevity. 2020; 2020(?):1782659. doi: 10.1155/2020/1782659. [PMID: 33343803]
  • Youyi Zhang, Zihan Ran, Miaomiao Tian, Yang Zhou, Jingcheng Yang, Juan Yin, Daru Lu, Rui Li, Jiang Zhong. Commensal Microbes Affect Host Humoral Immunity to Bordetella pertussis Infection. Infection and immunity. 2019 10; 87(10):. doi: 10.1128/iai.00421-19. [PMID: 31308086]
  • Guillaume Pelletier, Yong-Lai Feng, Karen Leingartner, Paleah Black. Co-administration of a Rhododendron tomentosum extract does not affect mercury tissue concentrations and excretion rate in methylmercury-treated adult male rats. BMC research notes. 2019 Jul; 12(1):369. doi: 10.1186/s13104-019-4409-7. [PMID: 31262338]
  • K H Huen, F Nik-Ahd, L Chen, S Lerman, J Singer. Neomycin-polymyxin or gentamicin bladder instillations decrease symptomatic urinary tract infections in neurogenic bladder patients on clean intermittent catheterization. Journal of pediatric urology. 2019 Apr; 15(2):178.e1-178.e7. doi: 10.1016/j.jpurol.2018.12.001. [PMID: 30611650]
  • Piotr Konopelski, Marek Konop, Marta Gawrys-Kopczynska, Piotr Podsadni, Agnieszka Szczepanska, Marcin Ufnal. Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats. Nutrients. 2019 Mar; 11(3):. doi: 10.3390/nu11030591. [PMID: 30862081]
  • José A Murillo Pulgarín, Luisa F García Bermejo, Armando Carrasquero Durán. A fast and simple FIA-chemiluminescence method for the evaluation of Roselle flowers as scavenger of the free radicals generated by UV irradiated antibiotics. Journal of pharmaceutical and biomedical analysis. 2019 Feb; 164(?):630-635. doi: 10.1016/j.jpba.2018.11.004. [PMID: 30471635]
  • Ayush Jain, Bhupinder Singh Kalra, Siddharth Srivastava, Shalini Chawla. Effect of sofosbuvir and daclatasvir on lipid profile, glycemic control and quality of life index in chronic hepatitis C, genotype 3 patients. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology. 2019 Feb; 38(1):39-43. doi: 10.1007/s12664-019-00935-w. [PMID: 30710219]
  • Youn Hee Nam, Isabel Rodriguez, Seo Yeon Jeong, Thu Nguyen Minh Pham, Wanlapa Nuankaew, Yun Hee Kim, Rodrigo Castañeda, Seo Yule Jeong, Min Seon Park, Kye Wan Lee, Jung Suk Lee, Do Hoon Kim, Yu Hwa Park, Seung Hyun Kim, In Seok Moon, Se-Young Choung, Bin Na Hong, Kwang Won Jeong, Tong Ho Kang. Avocado Oil Extract Modulates Auditory Hair Cell Function through the Regulation of Amino Acid Biosynthesis Genes. Nutrients. 2019 Jan; 11(1):. doi: 10.3390/nu11010113. [PMID: 30626089]
  • Priscilla Marys Costa Dos Santos, Deividi Amaral, Ana Lucia Tararthuch, Ricardo Fernandez. Calcium-sensing receptor (CaSR) modulates vacuolar H+-ATPase activity in a cell model of proximal tubule. Clinical and experimental nephrology. 2018 Dec; 22(6):1258-1265. doi: 10.1007/s10157-018-1613-z. [PMID: 29961155]
  • Hong-Di Ma, Zhi-Bin Zhao, Wen-Tao Ma, Qing-Zhi Liu, Cai-Yue Gao, Liang Li, Jinjun Wang, Koichi Tsuneyama, Bin Liu, Weici Zhang, Yongjian Zhou, M Eric Gershwin, Zhe-Xiong Lian. Gut microbiota translocation promotes autoimmune cholangitis. Journal of autoimmunity. 2018 12; 95(?):47-57. doi: 10.1016/j.jaut.2018.09.010. [PMID: 30340822]
  • A Aghraz, Q Benameur, T Gervasi, L Ait Dra, M H Ben-Mahdi, M Larhsini, M Markouk, N Cicero. Antibacterial activity of Cladanthus arabicus and Bubonium imbricatum essential oils alone and in combination with conventional antibiotics against Enterobacteriaceae isolates. Letters in applied microbiology. 2018 Aug; 67(2):175-182. doi: 10.1111/lam.13007. [PMID: 29763981]
  • Pierre-Florent Petit, Philippe Hantson, Michel Jadoul, Valentine Gillion. The Case Severe hypokalemia complicated by a syncope. Kidney international. 2018 07; 94(1):225-226. doi: 10.1016/j.kint.2017.12.009. [PMID: 29933854]
  • Stephanie A Bora, Mary J Kennett, Philip B Smith, Andrew D Patterson, Margherita T Cantorna. Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics. The Journal of nutritional biochemistry. 2018 06; 56(?):65-73. doi: 10.1016/j.jnutbio.2018.01.011. [PMID: 29459310]
  • Yang Yang, Hao-Jie He, Hao Chang, Yao Yu, Mei-Bing Yang, Yun He, Zhen-Chuan Fan, Suri S Iyer, Peng Yu. Multivalent oleanolic acid human serum albumin conjugate as nonglycosylated neomucin for influenza virus capture and entry inhibition. European journal of medicinal chemistry. 2018 Jan; 143(?):1723-1731. doi: 10.1016/j.ejmech.2017.10.070. [PMID: 29146135]
  • Yanli Wu, Yongdong Feng, Yanling Li, Yiping Xu, Nian Shi, Guo-Fu Hu, Yunxia Wu. Sub-chronic 90-day toxicity of neamine in SD rats and its anti-liver cancer activity in vitro and in vivo. Toxicology and applied pharmacology. 2017 Jan; 315(?):50-59. doi: 10.1016/j.taap.2016.12.006. [PMID: 27940282]
  • Mark R Bleackley, Jennifer A E Payne, Brigitte M E Hayes, Thomas Durek, David J Craik, Thomas M A Shafee, Ivan K H Poon, Mark D Hulett, Nicole L van der Weerden, Marilyn A Anderson. Nicotiana alata Defensin Chimeras Reveal Differences in the Mechanism of Fungal and Tumor Cell Killing and an Enhanced Antifungal Variant. Antimicrobial agents and chemotherapy. 2016 10; 60(10):6302-12. doi: 10.1128/aac.01479-16. [PMID: 27503651]
  • Ashish Sachan, Muslum Ilgu, Aaron Kempema, George A Kraus, Marit Nilsen-Hamilton. Specificity and Ligand Affinities of the Cocaine Aptamer: Impact of Structural Features and Physiological NaCl. Analytical chemistry. 2016 08; 88(15):7715-23. doi: 10.1021/acs.analchem.6b01633. [PMID: 27348073]
  • Youjia Hu, Ping Jin, Jian Peng, Xiaojun Zhang, F Susan Wong, Li Wen. Different immunological responses to early-life antibiotic exposure affecting autoimmune diabetes development in NOD mice. Journal of autoimmunity. 2016 08; 72(?):47-56. doi: 10.1016/j.jaut.2016.05.001. [PMID: 27178773]
  • Guillaume Sautrey, Micheline El Khoury, Andreia Giro Dos Santos, Louis Zimmermann, Magali Deleu, Laurence Lins, Jean-Luc Décout, Marie-Paule Mingeot-Leclercq. Negatively Charged Lipids as a Potential Target for New Amphiphilic Aminoglycoside Antibiotics: A BIOPHYSICAL STUDY. The Journal of biological chemistry. 2016 Jun; 291(26):13864-74. doi: 10.1074/jbc.m115.665364. [PMID: 27189936]
  • Humberto M Barreto, Kivia M R N Coelho, Josie H L Ferreira, Bernadete H C Dos Santos, Aislan P L de Abreu, Henrique D M Coutinho, Romezio A C da Silva, Taciana O de Sousa, Antonia M das G L Citó, José A D Lopes. Enhancement of the antibiotic activity of aminoglycosides by extracts from Anadenanthera colubrine (Vell.) Brenan var. cebil against multi-drug resistant bacteria. Natural product research. 2016 Jun; 30(11):1289-92. doi: 10.1080/14786419.2015.1049177. [PMID: 26158209]
  • Masaru Motojima, Sanae Ogiwara, Taiji Matsusaka, Sang Yong Kim, Nobuho Sagawa, Koichiro Abe, Masato Ohtsuka. Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system. Mammalian genome : official journal of the International Mammalian Genome Society. 2016 Feb; 27(1-2):62-9. doi: 10.1007/s00335-015-9610-y. [PMID: 26542959]
  • Atsushi Murai, Kazuki Kitahara, Shouta Okumura, Misato Kobayashi, Fumihiko Horio. Oral antibiotics enhance antibody responses to keyhole limpet hemocyanin in orally but not muscularly immunized chickens. Animal science journal = Nihon chikusan Gakkaiho. 2016 Feb; 87(2):257-65. doi: 10.1111/asj.12424. [PMID: 26304689]
  • Qingqing Wang, Lili Qian, Shengwang Jiang, Chunbo Cai, Dezun Ma, Pengfei Gao, Hegang Li, Ke Jiang, Maoxue Tang, Jian Hou, Jie Liu, Wentao Cui. Safety Evaluation of Neo Transgenic Pigs by Studying Changes in Gut Microbiota Using High-Throughput Sequencing Technology. PloS one. 2016; 11(3):e0150937. doi: 10.1371/journal.pone.0150937. [PMID: 26966911]
  • Yu V Karpets, Yu E Kolupaev, T O Yastreb. SIGNAL MEDIATORS AT INDUCTION OF HEAT RESISTANCE OF WHEAT PLANTLETS BY SHORT-TERM HEATING. Ukrainian biochemical journal. 2015 Nov; 87(6):104-12. doi: 10.15407/ubj87.06.104. [PMID: 27025064]
  • R V Pereira, J D Siler, K J Cummings, M A Davis, L D Warnick. Effect of heifer-raising practices on E. coli antimicrobial resistance and Salmonella prevalence in heifer raisers. Epidemiology and infection. 2015 Nov; 143(15):3256-65. doi: 10.1017/s0950268815000357. [PMID: 25904042]
  • Tien-Hau Lien, Ling-Nan Bu, Jia-Feng Wu, Huey-Ling Chen, An-Chyi Chen, Ming-Wei Lai, Hsiang-Hung Shih, I-Hsien Lee, Hong-Yuan Hsu, Yen-Hsuan Ni, Mei-Hwei Chang. Use of Lactobacillus casei rhamnosus to Prevent Cholangitis in Biliary Atresia After Kasai Operation. Journal of pediatric gastroenterology and nutrition. 2015 May; 60(5):654-8. doi: 10.1097/mpg.0000000000000676. [PMID: 25534776]
  • Yaping Liu, Xiaoyan Zhang, Songlin An, Yanli Wu, Guofu Hu, Yunxia Wu. Pharmacokinetics of neamine in rats and anti-cervical cancer activity in vitro and in vivo. Cancer chemotherapy and pharmacology. 2015 Mar; 75(3):465-74. doi: 10.1007/s00280-014-2658-7. [PMID: 25552400]
  • Kun Huang, Xuemei Wang, Yanjun Liu, Yi Zhao. CRAC channel is inhibited by neomycin in a Ptdlns(4,5)P2-independent manner. Cell biochemistry and function. 2015 Mar; 33(2):97-100. doi: 10.1002/cbf.3088. [PMID: 25663624]
  • Anand Bala Subramaniam, Mathieu Gonidec, Nathan D Shapiro, Kayleigh M Kresse, George M Whitesides. Metal-amplified Density Assays, (MADAs), including a Density-Linked Immunosorbent Assay (DeLISA). Lab on a chip. 2015 Feb; 15(4):1009-22. doi: 10.1039/c4lc01161a. [PMID: 25474561]
  • Mahmoud A Omar, Mohamed A Hammad, Dalia M Nagy, Alshymaa A Aly. Development of spectrofluorimetric method for determination of certain aminoglycoside drugs in dosage forms and human plasma through condensation with ninhydrin and phenyl acetaldehyde. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015 Feb; 136 Pt C(?):1760-6. doi: 10.1016/j.saa.2014.10.079. [PMID: 25467667]
  • Tanmaya Joshi, Zhi Xiang Voo, Bim Graham, Leone Spiccia, Lisandra L Martin. Real-time examination of aminoglycoside activity towards bacterial mimetic membranes using Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). Biochimica et biophysica acta. 2015 Feb; 1848(2):385-91. doi: 10.1016/j.bbamem.2014.10.019. [PMID: 25450807]
  • Qi Li, Na Li, Chun-Yi Liu, Rui Xu, Victor P Kolosov, Juliy M Perelman, Xiang-Dong Zhou. Ezrin/Exocyst complex regulates mucin 5AC secretion induced by neutrophil elastase in human airway epithelial cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2015; 35(1):326-38. doi: 10.1159/000369699. [PMID: 25591774]
  • Yu E Kolupaev, A A Vayner, T O Yastreb, A I Oboznyi, V A Khripach. [Role of Ca ions in the induction of heat-resistance of wheat coleoptiles by brassinosteroids]. Ukrainian biochemical journal. 2015 Jan; 87(1):127-33. doi: . [PMID: 26036139]
  • Jong Bae Seo, Seung-Ryoung Jung, Weigang Huang, Qisheng Zhang, Duk-Su Koh. Charge Shielding of PIP2 by Cations Regulates Enzyme Activity of Phospholipase C. PloS one. 2015; 10(12):e0144432. doi: 10.1371/journal.pone.0144432. [PMID: 26658739]
  • W Mattes, K Davis, E Fabian, J Greenhaw, M Herold, R Looser, W Mellert, S Groeters, H Marxfeld, N Moeller, G Montoya-Parra, A Prokoudine, B van Ravenzwaay, V Strauss, T Walk, H Kamp. Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma. Toxicology letters. 2014 Nov; 230(3):467-78. doi: 10.1016/j.toxlet.2014.07.021. [PMID: 25086301]
  • Anna Boccaccio, Joachim Scholz-Starke, Shin Hamamoto, Nina Larisch, Margherita Festa, Paul Vijay Kanth Gutla, Alex Costa, Petra Dietrich, Nobuyuki Uozumi, Armando Carpaneto. The phosphoinositide PI(3,5)P₂ mediates activation of mammalian but not plant TPC proteins: functional expression of endolysosomal channels in yeast and plant cells. Cellular and molecular life sciences : CMLS. 2014 Nov; 71(21):4275-83. doi: 10.1007/s00018-014-1623-2. [PMID: 24770793]
  • Juan Pablo Maianti, Hiroki Kanazawa, Paola Dozzo, Rowena D Matias, Lee Ann Feeney, Eliana S Armstrong, Darin J Hildebrandt, Timothy R Kane, Micah J Gliedt, Adam A Goldblum, Martin S Linsell, James B Aggen, Jiro Kondo, Stephen Hanessian. Toxicity modulation, resistance enzyme evasion, and A-site X-ray structure of broad-spectrum antibacterial neomycin analogs. ACS chemical biology. 2014 Sep; 9(9):2067-73. doi: 10.1021/cb5003416. [PMID: 25019242]
  • C-W T Chang, J Y Takemoto. Antifungal Amphiphilic Aminoglycosides. MedChemComm. 2014 Aug; 5(8):1048-1057. doi: 10.1039/c4md00078a. [PMID: 25110571]
  • Jyothilakshmi Vadassery, Michael Reichelt, Guillermo H Jimenez-Aleman, Wilhelm Boland, Axel Mithöfer. Neomycin inhibition of (+)-7-iso-jasmonoyl-L-isoleucine accumulation and signaling. Journal of chemical ecology. 2014 Jul; 40(7):676-86. doi: 10.1007/s10886-014-0448-7. [PMID: 24859518]
  • Youcai Zhang, Pallavi B Limaye, Helen J Renaud, Curtis D Klaassen. Effect of various antibiotics on modulation of intestinal microbiota and bile acid profile in mice. Toxicology and applied pharmacology. 2014 Jun; 277(2):138-45. doi: 10.1016/j.taap.2014.03.009. [PMID: 24657338]
  • Fernando Casare, Daiane Milan, Ricardo Fernandez. Stimulation of calcium-sensing receptor increases biochemical H⁺-ATPase activity in mouse cortex and outer medullary regions. Canadian journal of physiology and pharmacology. 2014 Mar; 92(3):181-8. doi: 10.1139/cjpp-2013-0256. [PMID: 24593782]
  • Kesha Rana, Michele V Clarke, Jeffrey D Zajac, Rachel A Davey, Helen E MacLean. Normal phenotype in conditional androgen receptor (AR) exon 3-floxed neomycin-negative male mice. Endocrine research. 2014; 39(3):130-5. doi: 10.3109/07435800.2013.864303. [PMID: 24467187]
  • Isaac Oludare Oluwayemi, Abiola Olufunmilayo Oduwole, Elizabeth Oyenusi, Alphonsus Ndidi Onyiriuka, Muhammad Abdullahi, Olubunmi Benedicta Fakeye-Udeogu, Chidozie Jude Achonwa, Moustapha Kouyate. Iatrogenic Cushing's syndrome in children following nasal steroid. The Pan African medical journal. 2014; 17(?):237. doi: 10.11604/pamj.2014.17.237.3332. [PMID: 25170381]
  • Vinay Lomash, Satish C Pant. A novel decontaminant and wound healant formulation of N,N'-dichloro-bis[2,4,6-trichlorophenyl]urea against sulfur mustard-induced skin injury. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2014 Jan; 22(1):85-95. doi: 10.1111/wrr.12126. [PMID: 24393156]
  • Benedikt Huttner, Thomas Haustein, Ilker Uçkay, Gesuele Renzi, Andrew Stewardson, Danièle Schaerrer, Americo Agostinho, Antoine Andremont, Jacques Schrenzel, Didier Pittet, Stephan Harbarth. Decolonization of intestinal carriage of extended-spectrum β-lactamase-producing Enterobacteriaceae with oral colistin and neomycin: a randomized, double-blind, placebo-controlled trial. The Journal of antimicrobial chemotherapy. 2013 Oct; 68(10):2375-82. doi: 10.1093/jac/dkt174. [PMID: 23719234]
  • K J Davey, P D Cotter, O O'Sullivan, F Crispie, T G Dinan, J F Cryan, S M O'Mahony. Antipsychotics and the gut microbiome: olanzapine-induced metabolic dysfunction is attenuated by antibiotic administration in the rat. Translational psychiatry. 2013 Oct; 3(?):e309. doi: 10.1038/tp.2013.83. [PMID: 24084940]
  • Julia A Sampson, Jim Duston, Roger P Croll. Superficial neuromasts facilitate non-visual feeding by larval striped bass (Morone saxatilis). The Journal of experimental biology. 2013 Sep; 216(Pt 18):3522-30. doi: 10.1242/jeb.087395. [PMID: 23737563]
  • Ariadna Grau-Campistany, Anna Massaguer, Dolors Carrion-Salip, Flavia Barragán, Gerard Artigas, Paula López-Senín, Virtudes Moreno, Vicente Marchán. Conjugation of a Ru(II) arene complex to neomycin or to guanidinoneomycin leads to compounds with differential cytotoxicities and accumulation between cancer and normal cells. Molecular pharmaceutics. 2013 May; 10(5):1964-76. doi: 10.1021/mp300723b. [PMID: 23510087]
  • Bernhard Westermann, Simon Dörner, Sebastian Brauch, Angela Schaks, Ramona Heinke, Sebastian Stark, Floris L van Delft, Sander S van Berkel. CuAAC-mediated diversification of aminoglycoside-arginine conjugate mimics by non-reducing di- and trisaccharides. Carbohydrate research. 2013 Apr; 371(?):61-7. doi: 10.1016/j.carres.2013.02.003. [PMID: 23507494]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Soo Hyun Lee, Ji Hye An, Hwa Jeong Lee, Byung Hwa Jung. Evaluation of pharmacokinetic differences of acetaminophen in pseudo germ-free rats. Biopharmaceutics & drug disposition. 2012 Sep; 33(6):292-303. doi: 10.1002/bdd.1799. [PMID: 22806334]
  • Smritilekha Bera, Ramesh Dhondikubeer, Brandon Findlay, George G Zhanel, Frank Schweizer. Synthesis and antibacterial activities of amphiphilic neomycin B-based bilipid conjugates and fluorinated neomycin B-based lipids. Molecules (Basel, Switzerland). 2012 Aug; 17(8):9129-41. doi: 10.3390/molecules17089129. [PMID: 22858839]
  • Neil M Foden, Theo Joseph. Common treatment for epistaxis contains peanut oil. BMJ (Clinical research ed.). 2012 Jul; 345(?):e4785. doi: 10.1136/bmj.e4785. [PMID: 22802405]
  • Gurunadh R Chichili, Robert C Cail, William Rodgers. Cytoskeletal modulation of lipid interactions regulates Lck kinase activity. The Journal of biological chemistry. 2012 Jul; 287(29):24186-94. doi: 10.1074/jbc.m111.320747. [PMID: 22613726]
  • Alberto González, María de los Angeles Cabrera, Macarena Mellado, Susana Cabello, Seabastián Márquez, Bernardo Morales, Alejandra Moenne. Copper-induced intracellular calcium release requires extracellular calcium entry and activation of L-type voltage-dependent calcium channels in Ulva compressa. Plant signaling & behavior. 2012 Jul; 7(7):728-32. doi: 10.4161/psb.20355. [PMID: 22751323]
  • A V Sokolov, V A Kostevich, D N Romanico, E T Zakharova, V B Vasilyev. Two-stage method for purification of ceruloplasmin based on its interaction with neomycin. Biochemistry. Biokhimiia. 2012 Jun; 77(6):631-8. doi: 10.1134/s0006297912060107. [PMID: 22817463]
  • V Lomash, S E Jadhav, F Ahmed, R Vijayaraghavan, S C Pant. Evaluation of wound-healing formulation against sulphur mustard-induced skin injury in mice. Human & experimental toxicology. 2012 Jun; 31(6):588-605. doi: 10.1177/0960327111429139. [PMID: 22144726]
  • Kathryn M Onesios, Edward J Bouwer. Biological removal of pharmaceuticals and personal care products during laboratory soil aquifer treatment simulation with different primary substrate concentrations. Water research. 2012 May; 46(7):2365-75. doi: 10.1016/j.watres.2012.02.001. [PMID: 22374299]
  • Olga Labovitiadi, Andrew J Lamb, Kerr H Matthews. In vitro efficacy of antimicrobial wafers against methicillin-resistant Staphylococcus aureus. Therapeutic delivery. 2012 Apr; 3(4):443-55. doi: 10.4155/tde.12.27. [PMID: 22834076]
  • K D May, J E Wells, C V Maxwell, W T Oliver. Granulated lysozyme as an alternative to antibiotics improves growth performance and small intestinal morphology of 10-day-old pigs. Journal of animal science. 2012 Apr; 90(4):1118-25. doi: 10.2527/jas.2011-4297. [PMID: 22064735]
  • Geum-Hwa Lee, Hyung-Ryong Kim, Han-Jung Chae. Bax inhibitor-1 regulates the expression of P450 2E1 through enhanced lysosome activity. The international journal of biochemistry & cell biology. 2012 Apr; 44(4):600-11. doi: 10.1016/j.biocel.2011.12.017. [PMID: 22230367]
  • Mathieu Mével, Matthieu Sainlos, Benoît Chatin, Noufissa Oudrhiri, Michèle Hauchecorne, Olivier Lambert, Jean-Pierre Vigneron, Pierre Lehn, Bruno Pitard, Jean-Marie Lehn. Paromomycin and neomycin B derived cationic lipids: synthesis and transfection studies. Journal of controlled release : official journal of the Controlled Release Society. 2012 Mar; 158(3):461-9. doi: 10.1016/j.jconrel.2011.12.019. [PMID: 22226775]
  • Brandon Findlay, George G Zhanel, Frank Schweizer. Neomycin-phenolic conjugates: polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding. Bioorganic & medicinal chemistry letters. 2012 Feb; 22(4):1499-503. doi: 10.1016/j.bmcl.2012.01.025. [PMID: 22285320]
  • G M Lingaraju, V Krishna, H Joy Hoskeri, K Pradeepa, Venkatesh, P Suresh Babu. Wound healing promoting activity of stem bark extract of Semecarpus anacardium using rats. Natural product research. 2012; 26(24):2344-7. doi: 10.1080/14786419.2012.656108. [PMID: 22324385]
  • Dale W Hailey, Brock Roberts, Kelly N Owens, Andrew K Stewart, Tor Linbo, Remy Pujol, Seth L Alper, Edwin W Rubel, David W Raible. Loss of Slc4a1b chloride/bicarbonate exchanger function protects mechanosensory hair cells from aminoglycoside damage in the zebrafish mutant persephone. PLoS genetics. 2012; 8(10):e1002971. doi: 10.1371/journal.pgen.1002971. [PMID: 23071446]
  • Mark Kwaaitaal, Rik Huisman, Jens Maintz, Anja Reinstädler, Ralph Panstruga. Ionotropic glutamate receptor (iGluR)-like channels mediate MAMP-induced calcium influx in Arabidopsis thaliana. The Biochemical journal. 2011 Dec; 440(3):355-65. doi: 10.1042/bj20111112. [PMID: 21848515]
  • Guanying Shi, Xingang Zhang, Lang Wu, Jin Xie, Ke Tao, Taiping Hou. Mutational biosynthesis of neomycin analogs by a mutant of neomycin-producing Streptomyces fradiae. Folia microbiologica. 2011 Nov; 56(6):555-61. doi: 10.1007/s12223-011-0082-5. [PMID: 22083789]
  • Sunita Shailajan, Sasikumar Menon, Suhas Pednekar, Ashish Singh. Wound healing efficacy of Jatyadi Taila: in vivo evaluation in rat using excision wound model. Journal of ethnopharmacology. 2011 Oct; 138(1):99-104. doi: 10.1016/j.jep.2011.08.050. [PMID: 21907784]
  • Myriam Ouberai, Farid El Garch, Antoine Bussiere, Mickael Riou, David Alsteens, Laurence Lins, Isabelle Baussanne, Yves F Dufrêne, Robert Brasseur, Jean-Luc Decout, Marie-Paule Mingeot-Leclercq. The Pseudomonas aeruginosa membranes: a target for a new amphiphilic aminoglycoside derivative?. Biochimica et biophysica acta. 2011 Jun; 1808(6):1716-27. doi: 10.1016/j.bbamem.2011.01.014. [PMID: 21291859]