Glycosides (BioDeep_00000033950)
Main id: BioDeep_00000002362
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
4-[(1S,2R,3S,5S,7R,10R,11R,14S,15R,17R)-3,7,11,17-tetrahydroxy-2-(hydroxymethyl)-15-methyl-5-{[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2,5-dihydrofuran-2-one
化学式: C29H44O12 (584.2833)
中文名称: G毒毛旋花苷
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(C(C(O1)OC2CC(C3(C4C(CCC3(C2)O)C5(CCC(C5(CC4O)C)C6=CC(=O)OC6)O)CO)O)O)O)O
InChI: InChI=1S/C29H44O12/c1-13-22(34)23(35)24(36)25(40-13)41-15-8-19(32)28(12-30)21-17(3-5-27(28,37)9-15)29(38)6-4-16(14-7-20(33)39-11-14)26(29,2)10-18(21)31/h7,13,15-19,21-25,30-32,34-38H,3-6,8-12H2,1-2H3/t13-,15+,16+,17-,18-,19+,21-,22-,23-,24-,25+,26-,27-,28-,29-/m1/s1
描述信息
Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. Glycosides is found in allspice, fig, and apricot.
Glycosides is found in allspice. Ouabain, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation
C - Cardiovascular system > C01 - Cardiac therapy > C01A - Cardiac glycosides > C01AC - Strophanthus glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D013328 - Strophanthins
D002317 - Cardiovascular Agents
D004791 - Enzyme Inhibitors
同义名列表
26 个代谢物同义名
4-[(1S,2R,3S,5S,7R,10R,11R,14S,15R,17R)-3,7,11,17-tetrahydroxy-2-(hydroxymethyl)-15-methyl-5-{[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2,5-dihydrofuran-2-one; 4-[(1S,2R,3S,5S,7R,10R,11R,14S,15R,17R)-3,7,11,17-tetrahydroxy-2-(hydroxymethyl)-15-methyl-5-{[(2R,3R,4R,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-5H-furan-2-one; Ouabagenin L-Rhamnoside; Gratus strophanthin; Acolongifloroside K; Acolongifloriside K; Strophanthin g; g Strophanthin; G-Strophanthin; Acocantherin; Purostrophan; g-Strophicor; Strophoperm; Solufantina; Rectobaina; Strophosan; Glycosides; Strophalen; Strodival; Gratibain; Astrobain; Ouabaine; Kombetin; Ouabain; Uabaina; Ouabain
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:472805
- KEGG: C01443
- PubChem: 439501
- PubChem: 637579
- HMDB: HMDB0031448
- DrugBank: DB01092
- ChEMBL: CHEMBL222863
- Wikipedia: Glycoside
- MeSH: Glycosides
- MeSH: Ouabain
- KNApSAcK: C00003633
- foodb: FDB005482
- chemspider: 553182
- CAS: 630-60-4
- PubChem: 4621
- LipidMAPS: LMST01120022
- PDB-CCD: OBN
- 3DMET: B01451
- NIKKAJI: J6.892F
- KNApSAcK: 472805
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
5 个相关的物种来源信息
- 141525 - Acokanthera oppositifolia: 10.4102/SAJS.V105I7/8.120
- 1220069 - Acokanthera schimperi: 10.1016/0378-8741(85)90094-7
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 392618 - Cunila: 10.1007/S00299-018-2303-8
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michael Baum, Susanne Dobler. Fecal Deployment: An Alternative Way of Defensive Host Plant Cardenolide Use by Lilioceris merdigera Larvae.
Journal of chemical ecology.
2024 Feb; 50(1-2):63-70. doi:
10.1007/s10886-023-01465-8. [PMID: 38062246] - Dmitry A Sibarov, Zoia D Zhuravleva, Margarita A Ilina, Sergei I Boikov, Yulia D Stepanenko, Tatiana V Karelina, Sergei M Antonov. Unveiling the Role of Cholesterol in Subnanomolar Ouabain Rescue of Cortical Neurons from Calcium Overload Caused by Excitotoxic Insults.
Cells.
2023 08; 12(15):. doi:
10.3390/cells12152011. [PMID: 37566090] - Laura Espinosa Del Alba, Georg Petschenka. No physiological costs of dual sequestration of chemically different plant toxins in the milkweed bug Spilostethus saxatilis (Heteroptera: Lygaeidae).
Journal of insect physiology.
2023 Apr; ?(?):104508. doi:
10.1016/j.jinsphys.2023.104508. [PMID: 37011856] - Patricia L Jones, Kyle R Martin, Sejal V Prachand, Amy P Hastings, Christophe Duplais, Anurag A Agrawal. Compound-Specific Behavioral and Enzymatic Resistance to Toxic Milkweed Cardenolides in a Generalist Bumblebee Pollinator.
Journal of chemical ecology.
2023 Feb; ?(?):. doi:
10.1007/s10886-023-01408-3. [PMID: 36745328] - Tao Song, Yuanyuan Hao, Mingye Wang, Tongtong Li, Chi Zhao, Jiajia Li, Yunlong Hou. Sophoridine manifests as a leading compound for anti-arrhythmia with multiple ion-channel blocking effects.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jan; 112(?):154688. doi:
10.1016/j.phymed.2023.154688. [PMID: 36738478] - Gokhan Yilmaz, Mustafa Boz, Alper B Iskit. The Effects of Lipopolysaccharide Derivatives in Rodent Models of Cardiac Arrhythmia.
Anatolian journal of cardiology.
2022 12; 26(12):886-892. doi:
10.5152/anatoljcardiol.2022.1524. [PMID: 35949121] - Violetta V Kravtsova, Arina A Fedorova, Maria V Tishkova, Alexandra A Livanova, Viacheslav O Matytsin, Viacheslav P Ganapolsky, Oleg V Vetrovoy, Igor I Krivoi. Short-Term Mild Hypoxia Modulates Na,K-ATPase to Maintain Membrane Electrogenesis in Rat Skeletal Muscle.
International journal of molecular sciences.
2022 Oct; 23(19):. doi:
10.3390/ijms231911869. [PMID: 36233169] - Violetta V Kravtsova, Arina A Fedorova, Maria V Tishkova, Alexandra A Livanova, Oleg V Vetrovoy, Alexander G Markov, Vladimir V Matchkov, Igor I Krivoi. Chronic Ouabain Prevents Radiation-Induced Reduction in the α2 Na,K-ATPase Function in the Rat Diaphragm Muscle.
International journal of molecular sciences.
2022 Sep; 23(18):. doi:
10.3390/ijms231810921. [PMID: 36142836] - Takuto Fujii, Mizuki Katoh, Manami Ootsubo, Oanh T T Nguyen, Mayumi Iguchi, Takahiro Shimizu, Yoshiaki Tabuchi, Yasuharu Shimizu, Hiroshi Takeshima, Hideki Sakai. Cardiac glycosides stimulate endocytosis of GLUT1 via intracellular Na+ ,K+ -ATPase α3-isoform in human cancer cells.
Journal of cellular physiology.
2022 07; 237(7):2980-2991. doi:
10.1002/jcp.30762. [PMID: 35511727] - Maciej Włodarczyk, Michał Gleńsk. An in-depth look into a well-known herbal drug: Fingerprinting, isolation, identification, and content estimation of saponins in different Strophanthus seeds.
Planta medica.
2022 Jul; 88(8):576-586. doi:
10.1055/a-1586-1915. [PMID: 34474491] - Guoyao Wu, Xilong Li, Heewon Seo, Bryan A McLendon, Avery C Kramer, Fuller W Bazer, Gregory A Johnson. Osteopontin (OPN)/Secreted Phosphoprotein 1 (SPP1) Binds Integrins to Activate Transport of Ions Across the Porcine Placenta.
Frontiers in bioscience (Landmark edition).
2022 04; 27(4):117. doi:
10.31083/j.fbl2704117. [PMID: 35468676] - Paula Fernanda Kinoshita, Ana Maria Marques Orellana, Vinicius Watanabe Nakao, Natacha Medeiros de Souza Port's, Luis Eduardo Menezes Quintas, Elisa Mitiko Kawamoto, Cristoforo Scavone. The Janus face of ouabain in Na+ /K+ -ATPase and calcium signalling in neurons.
British journal of pharmacology.
2022 04; 179(8):1512-1524. doi:
10.1111/bph.15419. [PMID: 33644859] - Rif S El-Mallakh, Yonglin Gao, Michael Roberts, John Hamlyn. Sleep deprivation is associated with increased circulating levels of endogenous ouabain: Potential role in bipolar disorder.
Psychiatry research.
2022 03; 309(?):114399. doi:
10.1016/j.psychres.2022.114399. [PMID: 35078006] - Artem M Tverskoi, Yuri M Poluektov, Elizaveta A Klimanova, Vladimir A Mitkevich, Alexander A Makarov, Sergei N Orlov, Irina Yu Petrushanko, Olga D Lopina. Depth of the Steroid Core Location Determines the Mode of Na,K-ATPase Inhibition by Cardiotonic Steroids.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413268. [PMID: 34948068] - Metka Petrič, Anja Vidović, Klemen Dolinar, Katarina Miš, Alexander V Chibalin, Sergej Pirkmajer. Phosphorylation of Na+,K+-ATPase at Tyr10 of the α1-Subunit is Suppressed by AMPK and Enhanced by Ouabain in Cultured Kidney Cells.
The Journal of membrane biology.
2021 12; 254(5-6):531-548. doi:
10.1007/s00232-021-00209-7. [PMID: 34748042] - Lilian N D Silva, Israel J P Garcia, Jessica M M Valadares, Marco Tulio C Pessoa, Marina Marques Toledo, Matheus V Machado, Mileane Souza Busch, Isabella Rocha, José Augusto F P Villar, Georgia C Atella, Herica L Santos, Vanessa F Cortes, Leandro A Barbosa. Evaluation of Cardiotonic Steroid Modulation of Cellular Cholesterol and Phospholipid.
The Journal of membrane biology.
2021 12; 254(5-6):499-512. doi:
10.1007/s00232-021-00203-z. [PMID: 34716469] - Hung Caohuy, Ofer Eidelman, Tinghua Chen, Shufeng Liu, Qingfeng Yang, Alakesh Bera, Nathan I Walton, Tony T Wang, Harvey B Pollard. Common cardiac medications potently inhibit ACE2 binding to the SARS-CoV-2 Spike, and block virus penetration and infectivity in human lung cells.
Scientific reports.
2021 11; 11(1):22195. doi:
10.1038/s41598-021-01690-9. [PMID: 34773067] - Songpeng Yang, Shu Yang, Hongying Zhang, Hui Hua, Qingbin Kong, Jiao Wang, Yangfu Jiang. Targeting Na+ /K+ -ATPase by berbamine and ouabain synergizes with sorafenib to inhibit hepatocellular carcinoma.
British journal of pharmacology.
2021 11; 178(21):4389-4407. doi:
10.1111/bph.15616. [PMID: 34233013] - Mrudhula Sajeevadathan, Murray J Pettitt, Mary M Buhr. Are isoforms of capacitating Na+ K+ -ATPase localized to sperm head rafts?.
Molecular reproduction and development.
2021 11; 88(11):731-743. doi:
10.1002/mrd.23543. [PMID: 34658111] - Claudia G Vasquez, Vipul T Vachharajani, Carlos Garzon-Coral, Alexander R Dunn. Physical basis for the determination of lumen shape in a simple epithelium.
Nature communications.
2021 09; 12(1):5608. doi:
10.1038/s41467-021-25050-3. [PMID: 34556639] - Jan Škubník, Jiří Bejček, Vladimíra Svobodová Pavlíčková, Silvie Rimpelová. Repurposing Cardiac Glycosides: Drugs for Heart Failure Surmounting Viruses.
Molecules (Basel, Switzerland).
2021 Sep; 26(18):. doi:
10.3390/molecules26185627. [PMID: 34577097] - Samuel J Ghilardi, Mark S Aronson, Allyson E Sgro. Ventral stress fibers induce plasma membrane deformation in human fibroblasts.
Molecular biology of the cell.
2021 08; 32(18):1707-1723. doi:
10.1091/mbc.e21-03-0096. [PMID: 34191528] - Kristoffer Bernhem, Jacopo M Fontana, Daniel Svensson, Liang Zhang, Linnéa M Nilsson, Lena Scott, Hans Blom, Hjalmar Brismar, Anita Aperia. Super-resolution microscopy reveals that Na+/K+-ATPase signaling protects against glucose-induced apoptosis by deactivating Bad.
Cell death & disease.
2021 07; 12(8):739. doi:
10.1038/s41419-021-04025-8. [PMID: 34315852] - Alejandro Ogazon Del Toro, Lidia Jimenez, Mauricio Serrano Rubi, Marcelino Cereijido, Arturo Ponce. Ouabain Enhances Gap Junctional Intercellular Communication by Inducing Paracrine Secretion of Prostaglandin E2.
International journal of molecular sciences.
2021 Jun; 22(12):. doi:
10.3390/ijms22126244. [PMID: 34200582] - Jiří Bejček, Vojtěch Spiwok, Eva Kmoníčková, Silvie Rimpelová. Na+/K+-ATPase Revisited: On Its Mechanism of Action, Role in Cancer, and Activity Modulation.
Molecules (Basel, Switzerland).
2021 Mar; 26(7):. doi:
10.3390/molecules26071905. [PMID: 33800655] - Yunhui Xu, Pauline Marck, Minqi Huang, Jeffrey X Xie, Tong Wang, Joseph I Shapiro, Liquan Cai, Feng Feng, Zijian Xie. Biased Effect of Cardiotonic Steroids on Na/K-ATPase-Mediated Signal Transduction.
Molecular pharmacology.
2021 03; 99(3):217-225. doi:
10.1124/molpharm.120.000101. [PMID: 33495275] - Joseph K Ritter, Ashfaq Ahmad, Shobha Mummalaneni, Zdravka Daneva, Sara K Dempsey, Ningjun Li, Pin-Lan Li, Vijay Lyall. Mechanism of Diuresis and Natriuresis by Cannabinoids: Evidence for Inhibition of Na+-K+-ATPase in Mouse Kidney Thick Ascending Limb Tubules.
The Journal of pharmacology and experimental therapeutics.
2021 01; 376(1):1-11. doi:
10.1124/jpet.120.000163. [PMID: 33087396] - Liang Chen, Jing Yue, Shulin Zhou, Yali Hu, Juan Li. Ouabain Protects Nephrogenesis in Rats Experiencing Intrauterine Growth Restriction and Partially Restores Renal Function in Adulthood.
Reproductive sciences (Thousand Oaks, Calif.).
2021 01; 28(1):186-196. doi:
10.1007/s43032-020-00280-w. [PMID: 32767217] - Mauricio Serrano-Rubi, Lidia Jimenez, Jacqueline Martinez-Rendon, Marcelino Cereijido, Arturo Ponce. Ouabain Promotes Gap Junctional Intercellular Communication in Cancer Cells.
International journal of molecular sciences.
2020 Dec; 22(1):. doi:
10.3390/ijms22010358. [PMID: 33396341] - Ana F M Botelho, Ana L S Miranda, Thalita G Freitas, Paula F Milani, Tatiane Barreto, Jáder S Cruz, Marília M Melo. Comparative Cardiotoxicity of Low Doses of Digoxin, Ouabain, and Oleandrin.
Cardiovascular toxicology.
2020 12; 20(6):539-547. doi:
10.1007/s12012-020-09579-1. [PMID: 32488807] - Qien Wang, Jing Yue, Xuan Zhou, Meihong Zheng, Bei Cao, Juan Li. Ouabain regulates kidney metabolic profiling in rat offspring of intrauterine growth restriction induced by low-protein diet.
Life sciences.
2020 Oct; 259(?):118281. doi:
10.1016/j.lfs.2020.118281. [PMID: 32798554] - Junhyung Cho, Young Jae Lee, Je Hyoung Kim, Sang Il Kim, Sung Soon Kim, Byeong-Sun Choi, Jang-Hoon Choi. Antiviral activity of digoxin and ouabain against SARS-CoV-2 infection and its implication for COVID-19.
Scientific reports.
2020 10; 10(1):16200. doi:
10.1038/s41598-020-72879-7. [PMID: 33004837] - Jeppe Seamus Bayley, Jesper Givskov Sørensen, Martin Moos, Vladimír Koštál, Johannes Overgaard. Cold acclimation increases depolarization resistance and tolerance in muscle fibers from a chill-susceptible insect, Locusta migratoria.
American journal of physiology. Regulatory, integrative and comparative physiology.
2020 10; 319(4):R439-R447. doi:
10.1152/ajpregu.00068.2020. [PMID: 32847398] - Şahbender Koç, Sadettin Selçuk Baysal. Practical Method for Salt Intake Follow-Up in Hypertensive Patients.
Metabolic syndrome and related disorders.
2020 10; 18(8):353-361. doi:
10.1089/met.2020.0036. [PMID: 32580624] - Muhammad T Islam, Chandan Sarkar, Dina M El-Kersh, Sarmin Jamaddar, Shaikh J Uddin, Jamil A Shilpi, Mohammad S Mubarak. Natural products and their derivatives against coronavirus: A review of the non-clinical and pre-clinical data.
Phytotherapy research : PTR.
2020 Oct; 34(10):2471-2492. doi:
10.1002/ptr.6700. [PMID: 32248575] - Miroslava Vosahlikova, Lenka Roubalova, Kristina Cechova, Jonas Kaufman, Stanislav Musil, Ivan Miksik, Martin Alda, Petr Svoboda. Na+/K+-ATPase and lipid peroxidation in forebrain cortex and hippocampus of sleep-deprived rats treated with therapeutic lithium concentration for different periods of time.
Progress in neuro-psychopharmacology & biological psychiatry.
2020 08; 102(?):109953. doi:
10.1016/j.pnpbp.2020.109953. [PMID: 32360816] - Maria A Ivanova, Arina D Kokorina, Polina D Timofeeva, Tatiana V Karelina, Polina A Abushik, Julia D Stepanenko, Dmitry A Sibarov, Sergei M Antonov. Calcium Export from Neurons and Multi-Kinase Signaling Cascades Contribute to Ouabain Neuroprotection in Hyperhomocysteinemia.
Biomolecules.
2020 07; 10(8):. doi:
10.3390/biom10081104. [PMID: 32722349] - Meihua Ju, Sofia Ioannidou, Peter Munro, Olli Rämö, Helena Vihinen, Eija Jokitalo, David T Shima. A Na,K-ATPase-Fodrin-Actin Membrane Cytoskeleton Complex is Required for Endothelial Fenestra Biogenesis.
Cells.
2020 06; 9(6):. doi:
10.3390/cells9061387. [PMID: 32503129] - David Castro, Ronald Manger, Oscar Vilariño, Ana Gago-Martínez. Evaluation of Matrix Issues in the Applicability of the Neuro-2a Cell Based Assay on the Detection of CTX in Fish Samples.
Toxins.
2020 05; 12(5):. doi:
10.3390/toxins12050308. [PMID: 32397386] - Violetta V Kravtsova, Elena V Bouzinova, Vladimir V Matchkov, Igor I Krivoi. Skeletal Muscle Na,K-ATPase as a Target for Circulating Ouabain.
International journal of molecular sciences.
2020 Apr; 21(8):. doi:
10.3390/ijms21082875. [PMID: 32326025] - E A Klimanova, D A Fedorov, S V Sidorenko, P A Abramicheva, O D Lopina, S N Orlov. Ouabain and Marinobufagenin: Physiological Effects on Human Epithelial and Endothelial Cells.
Biochemistry. Biokhimiia.
2020 Apr; 85(4):507-515. doi:
10.1134/s0006297920040112. [PMID: 32569558] - Guan-Hao Zhao, Ya-Qi Qiu, Cheng-Wei Yang, Ih-Sheng Chen, Chin-Yu Chen, Shiow-Ju Lee. The cardenolides ouabain and reevesioside A promote FGF2 secretion and subsequent FGFR1 phosphorylation via converged ERK1/2 activation.
Biochemical pharmacology.
2020 02; 172(?):113741. doi:
10.1016/j.bcp.2019.113741. [PMID: 31812679] - Pedro Azalim, Fernando M do Monte, Mariana Manzano Rendeiro, Xiaofan Liu, George A O'Doherty, Carlos Frederico Fontes, Suzana Guimarães Leitão, Luis Eduardo M Quintas, François Noël. Conformational states of the pig kidney Na+/K+-ATPase differently affect bufadienolides and cardenolides: A directed structure-activity and structure-kinetics study.
Biochemical pharmacology.
2020 01; 171(?):113679. doi:
10.1016/j.bcp.2019.113679. [PMID: 31669257] - Pengfei Liang, Jason Mast, Wei Chen. Synchronization Modulation of Na/K Pumps Induced Membrane Potential Hyperpolarization in Both Physiological and Hyperkalemic Conditions.
The Journal of membrane biology.
2019 12; 252(6):577-586. doi:
10.1007/s00232-019-00080-7. [PMID: 31410502] - O Verdejo-Torres, C Flores-Maldonado, T Padilla-Benavides, J P Campos-Blázquez, I Larré, R Lara-Lemus, E Perez Salazar, M Cereijido, R G Contreras. Ouabain Accelerates Collective Cell Migration Through a cSrc and ERK1/2 Sensitive Metalloproteinase Activity.
The Journal of membrane biology.
2019 12; 252(6):549-559. doi:
10.1007/s00232-019-00066-5. [PMID: 31041466] - Francisco Triana-Martínez, Pilar Picallos-Rabina, Sabela Da Silva-Álvarez, Federico Pietrocola, Susana Llanos, Verónica Rodilla, Enrica Soprano, Pablo Pedrosa, Alba Ferreirós, Marta Barradas, Fernanda Hernández-González, Marta Lalinde, Neus Prats, Cristina Bernadó, Patricia González, María Gómez, Maria P Ikonomopoulou, Pablo J Fernández-Marcos, Tomás García-Caballero, Pablo Del Pino, Joaquín Arribas, Anxo Vidal, Miguel González-Barcia, Manuel Serrano, María I Loza, Eduardo Domínguez, Manuel Collado. Identification and characterization of Cardiac Glycosides as senolytic compounds.
Nature communications.
2019 10; 10(1):4731. doi:
10.1038/s41467-019-12888-x. [PMID: 31636264] - Elena Panizza, Liang Zhang, Jacopo Maria Fontana, Kozo Hamada, Daniel Svensson, Evgeny E Akkuratov, Lena Scott, Katsuhiko Mikoshiba, Hjalmar Brismar, Janne Lehtiö, Anita Aperia. Ouabain-regulated phosphoproteome reveals molecular mechanisms for Na+, K+-ATPase control of cell adhesion, proliferation, and survival.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 09; 33(9):10193-10206. doi:
10.1096/fj.201900445r. [PMID: 31199885] - Matthias Lingemann, Thomas McCarty, Xueqiao Liu, Ursula J Buchholz, Sonja Surman, Scott E Martin, Peter L Collins, Shirin Munir. The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells.
PLoS pathogens.
2019 08; 15(8):e1007963. doi:
10.1371/journal.ppat.1007963. [PMID: 31381610] - Neha Upmanyu, Raimund Dietze, Ahmed Bulldan, Georgios Scheiner-Bobis. Cardiotonic steroid ouabain stimulates steroidogenesis in Leydig cells via the α3 isoform of the sodium pump.
The Journal of steroid biochemistry and molecular biology.
2019 07; 191(?):105372. doi:
10.1016/j.jsbmb.2019.04.021. [PMID: 31042565] - Neelam Kumari, Snehlata Singh, Vandana Kumari, Siddhartha Kumar, Vinay Kumar, Antresh Kumar. Ouabain potentiates the antimicrobial activity of aminoglycosides against Staphylococcus aureus.
BMC complementary and alternative medicine.
2019 Jun; 19(1):119. doi:
10.1186/s12906-019-2532-6. [PMID: 31170971] - Gustavo C Dal-Pont, Wilson R Resende, Guilherme Bianchini, Fernanda F Gava, Bruna R Peterle, Kerolen S Trajano, Roger B Varela, João Quevedo, Samira S Valvassori. Tamoxifen has an anti-manic effect but not protect the brain against oxidative stress in an animal model of mania induced by ouabain.
Journal of psychiatric research.
2019 06; 113(?):181-189. doi:
10.1016/j.jpsychires.2019.03.020. [PMID: 30981159] - Luciano Amarelle, Jeremy Katzen, Masahiko Shigemura, Lynn C Welch, Héctor Cajigas, Christin Peteranderl, Diego Celli, Susanne Herold, Emilia Lecuona, Jacob I Sznajder. Cardiac glycosides decrease influenza virus replication by inhibiting cell protein translational machinery.
American journal of physiology. Lung cellular and molecular physiology.
2019 06; 316(6):L1094-L1106. doi:
10.1152/ajplung.00173.2018. [PMID: 30892074] - Linnéa M Nilsson, Liang Zhang, Alexander Bondar, Daniel Svensson, Annika Wernerson, Hjalmar Brismar, Lena Scott, Anita Aperia. Prompt apoptotic response to high glucose in SGLT-expressing renal cells.
American journal of physiology. Renal physiology.
2019 05; 316(5):F1078-F1089. doi:
10.1152/ajprenal.00615.2018. [PMID: 30864838] - Claudia Andrea Vilchis-Nestor, María Luisa Roldán, Angelina Leonardi, Juan G Navea, Teresita Padilla-Benavides, Liora Shoshani. Ouabain Enhances Cell-Cell Adhesion Mediated by β1 Subunits of the Na+,K+-ATPase in CHO Fibroblasts.
International journal of molecular sciences.
2019 Apr; 20(9):. doi:
10.3390/ijms20092111. [PMID: 31035668] - Rossella Iatrino, Chiara Lanzani, Elena Bignami, Nunzia Casamassima, Lorena Citterio, Roberta Meroni, Laura Zagato, Alberto Zangrillo, Ottavio Alfieri, Simone Fontana, Lorenza Macrina, Simona Delli Carpini, Elisabetta Messaggio, Elena Brioni, Giacomo Dell'Antonio, Paolo Manunta, John M Hamlyn, Marco Simonini. Lanosterol Synthase Genetic Variants, Endogenous Ouabain, and Both Acute and Chronic Kidney Injury.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2019 04; 73(4):504-512. doi:
10.1053/j.ajkd.2018.10.012. [PMID: 30660405] - Mrudhula Sajeevadathan, Murray J Pettitt, Mary Buhr. Interaction of ouabain and progesterone on induction of bull sperm capacitation.
Theriogenology.
2019 Mar; 126(?):191-198. doi:
10.1016/j.theriogenology.2018.12.003. [PMID: 30572274] - Israel José Pereira Garcia, Paula Fernanda Kinoshita, Lílian Nara David E Silva, Mileane De Souza Busch, Georgia Correa Atella, Cristoforo Scavone, Vanessa Faria Cortes, Leandro Augusto Barbosa, Hérica De Lima Santos. Ouabain attenuates oxidative stress and modulates lipid composition in hippocampus of rats in lipopolysaccharide-induced hypocampal neuroinflammation in rats.
Journal of cellular biochemistry.
2019 03; 120(3):4081-4091. doi:
10.1002/jcb.27693. [PMID: 30260008] - Juan Wang, Sayyed Hanif Ullah, Meihe Li, Miao Zhang, Fujun Zhang, Jin Zheng, Xiaofei Yan. DR region specific antibody ameliorated but ouabain worsened renal injury in nephrectomized rats through regulating Na,K-ATPase mediated signaling pathways.
Aging.
2019 02; 11(4):1151-1162. doi:
10.18632/aging.101815. [PMID: 30807290] - Marco Simonini, Paola Casanova, Lorena Citterio, Elisabetta Messaggio, Chiara Lanzani, Paolo Manunta. Reply: 'Comment on: Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases'.
International journal of molecular sciences.
2019 Jan; 20(3):. doi:
10.3390/ijms20030542. [PMID: 30696018] - Hauke Fürstenwerth. Comment on: Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases, Int. J. Mol. Sci. 2018, 19, 1948.
International journal of molecular sciences.
2019 01; 20(3):. doi:
10.3390/ijms20030505. [PMID: 30682854] - Aida Castillo, Carlos Ortuño-Pineda, Catalina Flores-Maldonado, Isabel Larre, Jacqueline Martínez Rendón, Lorena Hinojosa, Arturo Ponce, Alejandro Ogazón, Mauricio Serrano, Jesús Valdes, Rubén G Contreras, Marcelino Cereijido. Ouabain Modulates the Adherens Junction in Renal Epithelial Cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2019; 52(6):1381-1397. doi:
10.33594/000000097. [PMID: 31075189] - Noah B Gross, Nastaren Abad, David Lichtstein, Shiri Taron, Lorena Aparicio, Alfred N Fonteh, Xianghong Arakaki, Robert P Cowan, Samuel C Grant, Michael G Harrington. Endogenous Na+, K+-ATPase inhibitors and CSF [Na+] contribute to migraine formation.
PloS one.
2019; 14(6):e0218041. doi:
10.1371/journal.pone.0218041. [PMID: 31173612] - Thomas F Whayne. Clinical Use of Digitalis: A State of the Art Review.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2018 Dec; 18(6):427-440. doi:
10.1007/s40256-018-0292-1. [PMID: 30066080] - Fredi Cifuentes, Javier Palacios, Adrián Paredes, Chukwuemeka R Nwokocha, Cristian Paz. 8-Oxo-9-Dihydromakomakine Isolated from Aristotelia chilensis Induces Vasodilation in Rat Aorta: Role of the Extracellular Calcium Influx.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23113050. [PMID: 30469451] - François Noël, Pedro Azalim, Fernando M do Monte, Luis Eduardo M Quintas, Adriana Katz, Steven J D Karlish. Revisiting the binding kinetics and inhibitory potency of cardiac glycosides on Na+,K+-ATPase (α1β1): Methodological considerations.
Journal of pharmacological and toxicological methods.
2018 Nov; 94(Pt 2):64-72. doi:
10.1016/j.vascn.2018.09.001. [PMID: 30244071] - Cheng-Wei Yang, Hsin-Yu Chang, Yue-Zhi Lee, Hsing-Yu Hsu, Shiow-Ju Lee. The cardenolide ouabain suppresses coronaviral replication via augmenting a Na+/K+-ATPase-dependent PI3K_PDK1 axis signaling.
Toxicology and applied pharmacology.
2018 10; 356(?):90-97. doi:
10.1016/j.taap.2018.07.028. [PMID: 30053394] - Kaja Karaś, Anna Sałkowska, Aurelia Walczak-Drzewiecka, Katarzyna Ryba, Jarosław Dastych, Rafał A Bachorz, Marcin Ratajewski. The cardenolides strophanthidin, digoxigenin and dihydroouabain act as activators of the human RORγ/RORγT receptors.
Toxicology letters.
2018 Oct; 295(?):314-324. doi:
10.1016/j.toxlet.2018.07.002. [PMID: 29981919] - David J Kennedy, Fatimah K Khalaf, Brendan Sheehy, Malory E Weber, Brendan Agatisa-Boyle, Julijana Conic, Kayla Hauser, Charles M Medert, Kristen Westfall, Philip Bucur, Olga V Fedorova, Alexei Y Bagrov, W H Wilson Tang. Telocinobufagin, a Novel Cardiotonic Steroid, Promotes Renal Fibrosis via Na⁺/K⁺-ATPase Profibrotic Signaling Pathways.
International journal of molecular sciences.
2018 Aug; 19(9):. doi:
10.3390/ijms19092566. [PMID: 30158457] - Marco Simonini, Paola Casanova, Lorena Citterio, Elisabetta Messaggio, Chiara Lanzani, Paolo Manunta. Endogenous Ouabain and Related Genes in the Translation from Hypertension to Renal Diseases.
International journal of molecular sciences.
2018 07; 19(7):. doi:
10.3390/ijms19071948. [PMID: 29970843] - Vardaman M Buckalew. Role of endogenous digitalis-like factors in the clinical manifestations of severe preeclampsia: a sytematic review.
Clinical science (London, England : 1979).
2018 06; 132(12):1215-1242. doi:
10.1042/cs20171499. [PMID: 29930141] - Jin-Hua Guo, Ren-Wang Jiang, Jacob Lauwring Andersen, Mikael Esmann, Natalya U Fedosova. Spin-labeled derivatives of cardiotonic steroids as tools for characterization of the extracellular entrance to the binding site on Na+ ,K+ -ATPase.
The FEBS journal.
2018 06; 285(12):2292-2305. doi:
10.1111/febs.14480. [PMID: 29688626] - Ruibin Niu, Hao Gao, Yuan Zhou, Jie Zhang. Ouabain Attenuates Sepsis-Induced Immunosuppression in Mice by Activation and Anti-Apoptosis of T Cells.
Medical science monitor : international medical journal of experimental and clinical research.
2018 May; 24(?):2720-2727. doi:
10.12659/msm.906889. [PMID: 29717720] - Simona Pozzoli, Marco Simonini, Paolo Manunta. Predicting acute kidney injury: current status and future challenges.
Journal of nephrology.
2018 04; 31(2):209-223. doi:
10.1007/s40620-017-0416-8. [PMID: 28624882] - Shameem Sultana Syeda, Gladis Sánchez, Kwon Ho Hong, Jon E Hawkinson, Gunda I Georg, Gustavo Blanco. Design, Synthesis, and in Vitro and in Vivo Evaluation of Ouabain Analogues as Potent and Selective Na,K-ATPase α4 Isoform Inhibitors for Male Contraception.
Journal of medicinal chemistry.
2018 03; 61(5):1800-1820. doi:
10.1021/acs.jmedchem.7b00925. [PMID: 29291372] - Shabnam Mohammadi, Georg Petschenka, Susannah S French, Akira Mori, Alan H Savitzky. Snakes exhibit tissue-specific variation in cardiotonic steroid sensitivity of Na+/K+-ATPase.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2018 Mar; 217(?):21-26. doi:
10.1016/j.cbpb.2017.11.014. [PMID: 29223875] - Monika Keisham, Soumya Mukherjee, Satish C Bhatla. Mechanisms of Sodium Transport in Plants-Progresses and Challenges.
International journal of molecular sciences.
2018 Feb; 19(3):. doi:
10.3390/ijms19030647. [PMID: 29495332] - Hui Yu, Xiaoyu Cui, Jue Zhang, Joe X Xie, Moumita Banerjee, Sandrine V Pierre, Zijian Xie. Heterogeneity of signal transduction by Na-K-ATPase α-isoforms: role of Src interaction.
American journal of physiology. Cell physiology.
2018 02; 314(2):C202-C210. doi:
10.1152/ajpcell.00124.2017. [PMID: 29118027] - Israel José Pereira Garcia, Paula Fernanda Kinoshita, Italo de Oliveira Braga, Gabriela Machado Parreira, Julio Alberto Mignaco, Cristoforo Scavone, Leandro Augusto Barbosa, Hérica de Lima Santos. Ouabain attenuates the oxidative stress induced by lipopolysaccharides in the cerebellum of rats.
Journal of cellular biochemistry.
2018 02; 119(2):2156-2167. doi:
10.1002/jcb.26377. [PMID: 28857301] - Wen-Hsiang Chou, Ko-Lin Liu, Yung-Luen Shih, Ying-Ying Chuang, Jason Chou, Hsu-Feng Lu, Herng-Woei Jair, Ming-Zhe Lee, Man-Kuan Au, Jing-Gung Chung. Ouabain Induces Apoptotic Cell Death Through Caspase- and Mitochondria-dependent Pathways in Human Osteosarcoma U-2 OS Cells.
Anticancer research.
2018 01; 38(1):169-178. doi:
10.21873/anticanres.12205. [PMID: 29277770] - Mordecai P Blaustein. The pump, the exchanger, and the holy spirit: origins and 40-year evolution of ideas about the ouabain-Na+ pump endocrine system.
American journal of physiology. Cell physiology.
2018 01; 314(1):C3-C26. doi:
10.1152/ajpcell.00196.2017. [PMID: 28971835] - Christopher A Drummond, Xiaoming Fan, Steven T Haller, David J Kennedy, Jiang Liu, Jiang Tian. Na/K-ATPase signaling mediates miR-29b-3p regulation and cardiac fibrosis formation in mice with chronic kidney disease.
PloS one.
2018; 13(5):e0197688. doi:
10.1371/journal.pone.0197688. [PMID: 29775473] - José Guilherme F M Galvão, Luiz Henrique Agra Cavalcante-Silva, Deyse Cristina M Carvalho, Laércia Karla D P Ferreira, Talissa Mozzini Monteiro, Adriano Francisco Alves, Larissa Adilis M P Ferreira, Francisco Allysson A F Gadelha, Marcia Regina Piuvezam, Sandra Rodrigues-Mascarenhas. Ouabain attenuates ovalbumin-induced airway inflammation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2017 Dec; 66(12):1117-1130. doi:
10.1007/s00011-017-1092-9. [PMID: 28905075] - Mordecai P Blaustein. How does pressure overload cause cardiac hypertrophy and dysfunction? High-ouabain affinity cardiac Na+ pumps are crucial.
American journal of physiology. Heart and circulatory physiology.
2017 Nov; 313(5):H919-H930. doi:
10.1152/ajpheart.00131.2017. [PMID: 28733446] - Shuji Shimizu, Tsuyoshi Akiyama, Toru Kawada, Yusuke Sata, Michael James Turner, Masafumi Fukumitsu, Hiromi Yamamoto, Atsunori Kamiya, Toshiaki Shishido, Masaru Sugimachi. Sodium ion transport participates in non-neuronal acetylcholine release in the renal cortex of anesthetized rabbits.
The journal of physiological sciences : JPS.
2017 Sep; 67(5):587-593. doi:
10.1007/s12576-016-0489-5. [PMID: 27660058] - María M Amaral, Magalí C Girard, Romina S Álvarez, Adrienne W Paton, James C Paton, Horacio A Repetto, Flavia Sacerdoti, Cristina A Ibarra. Ouabain Protects Human Renal Cells against the Cytotoxic Effects of Shiga Toxin Type 2 and Subtilase Cytotoxin.
Toxins.
2017 07; 9(7):. doi:
10.3390/toxins9070226. [PMID: 28718802] - Marika Svrckova, Martina Zatloukalova, Petra Dvorakova, Dominika Coufalova, David Novak, Lenka Hernychova, Jan Vacek. Na+/K+-ATPase interaction with methylglyoxal as reactive metabolic side product.
Free radical biology & medicine.
2017 07; 108(?):146-154. doi:
10.1016/j.freeradbiomed.2017.03.024. [PMID: 28342847] - Jessica Venugopal, Jeffrey McDermott, Gladis Sanchez, Madhulika Sharma, Leandro Barbosa, Gail A Reif, Darren P Wallace, Gustavo Blanco. Ouabain promotes partial epithelial to mesenchymal transition (EMT) changes in human autosomal dominant polycystic kidney disease (ADPKD) cells.
Experimental cell research.
2017 06; 355(2):142-152. doi:
10.1016/j.yexcr.2017.04.001. [PMID: 28385574] - Leonardo Puppulin, Giuseppe Pezzotti, Hongxin Sun, Shigekuni Hosogi, Takashi Nakahari, Toshio Inui, Yasuaki Kumamoto, Hideo Tanaka, Yoshinori Marunaka. Raman micro-spectroscopy as a viable tool to monitor and estimate the ionic transport in epithelial cells.
Scientific reports.
2017 06; 7(1):3395. doi:
10.1038/s41598-017-03595-y. [PMID: 28611439] - Jessica Venugopal, Gustavo Blanco. On the Many Actions of Ouabain: Pro-Cystogenic Effects in Autosomal Dominant Polycystic Kidney Disease.
Molecules (Basel, Switzerland).
2017 May; 22(5):. doi:
10.3390/molecules22050729. [PMID: 28467389] - Miroslava Vosahlikova, Hana Ujcikova, Oleksandr Chernyavskiy, Jana Brejchova, Lenka Roubalova, Martin Alda, Petr Svoboda. Effect of therapeutic concentration of lithium on live HEK293 cells; increase of Na+/K+-ATPase, change of overall protein composition and alteration of surface layer of plasma membrane.
Biochimica et biophysica acta. General subjects.
2017 May; 1861(5 Pt A):1099-1112. doi:
10.1016/j.bbagen.2017.02.011. [PMID: 28215700] - Darpan Chakraborty, Olga V Fedorova, Alexei Y Bagrov, Hanoch Kaphzan. Selective ligands for Na+/K+-ATPase α isoforms differentially and cooperatively regulate excitability of pyramidal neurons in distinct brain regions.
Neuropharmacology.
2017 05; 117(?):338-351. doi:
10.1016/j.neuropharm.2017.02.016. [PMID: 28232062] - Horacio J Adrogué, Nicolaos E Madias. Sodium and potassium in the pathogenesis of hypertension: focus on the brain.
Current opinion in nephrology and hypertension.
2017 03; 26(2):106-113. doi:
10.1097/mnh.0000000000000301. [PMID: 27906749] - Lu Zhang, Meng-Xi Xu, Qing-Sheng Yin, Cai-Ying Zhu, Xue-Lian Cheng, Yi-Ran Ren, Peng-Wei Zhuang, Yan-Jun Zhang. Screening, verification, and analysis of biomarkers for drug-induced cardiac toxicity in vitro based on RTCA coupled with PCR Array technology.
Toxicology letters.
2017 Feb; 268(?):17-25. doi:
10.1016/j.toxlet.2017.01.007. [PMID: 28099878] - Zhengtao Li, Sujuan Li, Lin Hu, Fang Li, Alex Chun Cheung, Weizai Shao, Yuling Que, George Pek-Heng Leung, Cui Yang. MECHANISMS UNDERLYING ACTION OF XINMAILONG INJECTION, A TRADITIONAL CHINESE MEDICINE IN CARDIAC FUNCTION IMPROVEMENT.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2017; 14(2):241-252. doi:
10.21010/ajtcam.v14i2.26. [PMID: 28573241] - Else M Vedula, José Luis Alonso, M Amin Arnaout, Joseph L Charest. A microfluidic renal proximal tubule with active reabsorptive function.
PloS one.
2017; 12(10):e0184330. doi:
10.1371/journal.pone.0184330. [PMID: 29020011] - Li Meng, Yanting Wen, Min Zhou, Jian Li, Ting Wang, Peipei Xu, Jian Ouyang. Ouabain induces apoptosis and autophagy in Burkitt's lymphoma Raji cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Dec; 84(?):1841-1848. doi:
10.1016/j.biopha.2016.10.114. [PMID: 27894666] - Corey J Ketchem, Clayton D Conner, Rebecca D Murray, Madalyn DuPlessis, Eleanor D Lederer, Daniel Wilkey, Michael Merchant, Syed J Khundmiri. Low dose ouabain stimulates NaK ATPase α1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells.
Biochimica et biophysica acta.
2016 11; 1863(11):2624-2636. doi:
10.1016/j.bbamcr.2016.07.008. [PMID: 27496272] - Luca Villa, Roberta Buono, Mara Ferrandi, Isabella Molinari, Fabio Benigni, Arianna Bettiga, Giorgia Colciago, Masami Ikehata, Elisabetta Messaggio, Maria Pia Rastaldi, Francesco Montorsi, Andrea Salonia, Paolo Manunta. Ouabain Contributes to Kidney Damage in a Rat Model of Renal Ischemia-Reperfusion Injury.
International journal of molecular sciences.
2016 Oct; 17(10):. doi:
10.3390/ijms17101728. [PMID: 27754425] - Stefano Tentori, Elisabetta Messaggio, Elena Brioni, Nunzia Casamassima, Marco Simonini, Laura Zagato, John M Hamlyn, Paolo Manunta, Chiara Lanzani. Endogenous ouabain and aldosterone are coelevated in the circulation of patients with essential hypertension.
Journal of hypertension.
2016 10; 34(10):2074-80. doi:
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