Phosphoserine (BioDeep_00000003158)

 

Secondary id: BioDeep_00000027721, BioDeep_00000405235

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


(S)-2-Amino-3-hydroxypropanoic acid 3-phosphoric acid

化学式: C3H8NO6P (185.0089)
中文名称: O-磷酸-L-丝氨酸, 磷酸丝氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 36.76%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

Phosphoserine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/phosphoserine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000003158). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(C(C(=O)O)N)OP(=O)(O)O
InChI: InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)

描述信息

The phosphoric acid ester of serine. As a constituent (residue) of proteins, its side chain can undergo O-linked glycosylation. This might be important in explaining some of the devastating consequences of diabetes. It is one of three amino acid residues that are commonly phosphorylated by kinases during cell signalling in eukaryotes. Phosphorylated serine residues are often referred to as phosphoserine. Serine proteases are a common type of protease. Serine, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the L-stereoisomer appears in mammalian protein. It is not essential to the human diet, since it can be synthesized in the body from other metabolites, including glycine. Serine was first obtained from silk protein, a particularly rich source, in 1865. Its name is derived from the Latin for silk, sericum. Serines structure was established in 1902. [HMDB]
Phosphoserine is the phosphoric acid ester of the amino acid serine. It is found in essentially all living organisms ranging from microbes to plants to mammals. Phosphoserine is a component of many proteins as the result of posttranslational modifications to the native protein’s serine residue(s). The phosphorylation of the hydroxyl functional group in serine to produce phosphoserine is catalyzed by various types of kinases. Serine is one of three amino acid residues that are commonly phosphorylated by kinases during cell signalling in eukaryotes. Free phosphoserine is found in many biofluids and likely arises from the proteolysis of proteins containing phosphoserine residues (PMID: 7693088).
Acquisition and generation of the data is financially supported in part by CREST/JST.
KEIO_ID P060
DL-O-Phosphoserine, a normal metabolite in human biofluid, is an ester of serine and phosphoric acid.

同义名列表

30 个代谢物同义名

(S)-2-Amino-3-hydroxypropanoic acid 3-phosphoric acid; (S)-2-Amino-3-hydroxypropanoic acid 3-phosphate; (+)-L-Serine dihydrogen phosphoric acid (ester); (2S)-2-Amino-3-(phosphonooxy)propanoic acid; (S)-2-Amino-3-hydroxypropanoate 3-phosphate; (+)-L-Serine dihydrogen phosphate (ester); (2S)-2-Amino-3-(phosphonooxy)propanoate; L-Serine dihydrogen phosphate (ester); L-Serinephosphoric acid; L-O-Serine phosphate; L-Serinephosphorate; dl-O-Phosphoserine; O-Phospho-L-serine; 3-Phospho-L-serine; L-Serine phosphate; 3-O-Phosphoserine; L-Seryl phosphate; L-3-Phosphoserine; L-O-Phosphoserine; Phospho-L-serine; Plasmenylserine; L-Phosphoserine; O-Phosphoserine; 3-Phosphoserine; Dexfosfoserine; Phosphoserine; Fosforina; Phosphoserine; O-Phospho-L-serine; Phosphoserine



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(7)

BioCyc(1)

PlantCyc(0)

代谢反应

87 个相关的代谢反应过程信息。

Reactome(72)

BioCyc(2)

WikiPathways(2)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(9)

PharmGKB(0)

51 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 BCL2, BRCA1, CTNNB1, EGFR, MAPK14, MARK2, PIN1, PPA1, PSAT1, PSPH, TNK1, TP53
Peripheral membrane protein 1 TNK1
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 BCL2, EGFR, SPP1
Nucleus 8 BCL2, BRCA1, CTNNB1, EGFR, JUN, MAPK14, PIN1, TP53
cytosol 8 BCL2, CTNNB1, MAPK14, PIN1, PPA1, PSAT1, PSPH, TP53
dendrite 1 MARK2
nuclear body 1 BRCA1
centrosome 2 CTNNB1, TP53
nucleoplasm 7 BRCA1, CTNNB1, JUN, MAPK14, MARK2, PIN1, TP53
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 4 CTNNB1, EGFR, SPP1, TNF
lamellipodium 1 CTNNB1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 SPP1
Synapse 1 CTNNB1
cell cortex 1 CTNNB1
cell junction 2 CTNNB1, EGFR
cell surface 2 EGFR, TNF
glutamatergic synapse 4 CTNNB1, EGFR, MAPK14, PIN1
Golgi apparatus 1 SPP1
Golgi membrane 1 EGFR
lysosomal membrane 1 EGF
neuronal cell body 1 TNF
presynaptic membrane 1 CTNNB1
Cytoplasm, cytosol 1 PSPH
endosome 1 EGFR
plasma membrane 9 BRCA1, CTNNB1, EGF, EGFR, F2, MARK2, SPP1, TNF, TNK1
Membrane 8 BCL2, BRCA1, CTNNB1, EGF, EGFR, MARK2, TNK1, TP53
apical plasma membrane 1 EGFR
basolateral plasma membrane 2 CTNNB1, EGFR
extracellular exosome 8 BMP3, CTNNB1, EGF, F2, PPA1, PSAT1, REG1A, SPP1
endoplasmic reticulum 2 BCL2, TP53
extracellular space 8 BMP3, EGF, EGFR, F2, IGF1, REG1A, SPP1, TNF
perinuclear region of cytoplasm 3 CTNNB1, EGFR, SPP1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
mitochondrion 4 BCL2, MAPK14, MARK2, TP53
protein-containing complex 5 BCL2, BRCA1, CTNNB1, EGFR, TP53
Single-pass type I membrane protein 1 EGFR
Secreted 4 BMP3, F2, IGF1, SPP1
extracellular region 7 BMP3, EGF, F2, IGF1, MAPK14, SPP1, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 CTNNB1, JUN, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 TNF
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 TP53
Wnt signalosome 1 CTNNB1
midbody 1 PIN1
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 CTNNB1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 2 CTNNB1, TP53
focal adhesion 2 CTNNB1, EGFR
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
intracellular vesicle 1 EGFR
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 F2
fascia adherens 1 CTNNB1
lateral plasma membrane 2 CTNNB1, MARK2
nuclear speck 2 MAPK14, PIN1
receptor complex 1 EGFR
ciliary basal body 1 PIN1
chromatin 2 JUN, TP53
cell projection 1 SPP1
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Chromosome 1 BRCA1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
[Isoform 5]: Cytoplasm 1 BRCA1
spindle pole 2 CTNNB1, MAPK14
nuclear chromosome 1 JUN
actin filament 1 MARK2
blood microparticle 1 F2
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
site of double-strand break 1 TP53
Endomembrane system 1 CTNNB1
lateral element 1 BRCA1
Cell projection, dendrite 1 MARK2
Nucleus speckle 1 PIN1
euchromatin 2 CTNNB1, JUN
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ubiquitin ligase complex 1 BRCA1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
exocytic vesicle 1 IGF1
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 F2, SPP1
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
male germ cell nucleus 1 BRCA1
platelet alpha granule lumen 2 EGF, IGF1
XY body 1 BRCA1
beta-catenin-TCF complex 1 CTNNB1
presynaptic active zone cytoplasmic component 1 CTNNB1
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
ribonucleoprotein complex 1 BRCA1
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 1 CTNNB1
intracellular non-membrane-bounded organelle 1 BRCA1
postsynaptic cytosol 1 PIN1
DNA repair complex 1 BRCA1
catenin complex 1 CTNNB1
BRCA1-C complex 1 BRCA1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
BAD-BCL-2 complex 1 BCL2
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
BRCA1-A complex 1 BRCA1
BRCA1-B complex 1 BRCA1
BRCA1-BARD1 complex 1 BRCA1
gamma-tubulin ring complex 1 BRCA1
nuclear ubiquitin ligase complex 1 BRCA1
microtubule bundle 1 MARK2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Gang Wang, Xi Chen, Chengzhi Yu, Xiaobao Shi, Wenxian Lan, Chaofeng Gao, Jun Yang, Huiling Dai, Xiaowei Zhang, Huili Zhang, Boyu Zhao, Qi Xie, Nan Yu, Zuhua He, Yu Zhang, Ertao Wang. Release of a ubiquitin brake activates OsCERK1-triggered immunity in rice. Nature. 2024 May; 629(8014):1158-1164. doi: 10.1038/s41586-024-07418-9. [PMID: 38750355]
  • Chao Wang, Ren-Jie Tang, Senhao Kou, Xiaoshu Xu, Yi Lu, Kenda Rauscher, Angela Voelker, Sheng Luan. Mechanisms of calcium homeostasis orchestrate plant growth and immunity. Nature. 2024 Mar; 627(8003):382-388. doi: 10.1038/s41586-024-07100-0. [PMID: 38418878]
  • Huahua Sun, Xumin Lin, Huihui Zhang, Yixi Zhang, Zewen Liu. A consensus phosphoserine within the large cytoplasmic loop of insect nAChR α8 subunits modulated interaction between 14-3-3ε and nAChRs to regulate neonicotinoid efficacy. Pesticide biochemistry and physiology. 2023 May; 192(?):105384. doi: 10.1016/j.pestbp.2023.105384. [PMID: 37105614]
  • Can Si, Danqi Zeng, Zhenming Yu, Jaime A Teixeira da Silva, Jun Duan, Chunmei He, Jianxia Zhang. Transcriptomic and metabolomic analyses reveal the main metabolites in Dendrobium officinale leaves during the harvesting period. Plant physiology and biochemistry : PPB. 2022 Nov; 190(?):24-34. doi: 10.1016/j.plaphy.2022.08.026. [PMID: 36088784]
  • Suzan Kors, Christian Hacker, Chloe Bolton, Renate Maier, Lena Reimann, Emily J A Kitchener, Bettina Warscheid, Joseph L Costello, Michael Schrader. Regulating peroxisome-ER contacts via the ACBD5-VAPB tether by FFAT motif phosphorylation and GSK3β. The Journal of cell biology. 2022 03; 221(3):. doi: 10.1083/jcb.202003143. [PMID: 35019937]
  • Xiao Liang, Min Luo, Bin Shao, Jing-Yun Yang, An Tong, Rui-Bo Wang, Yan-Tong Liu, Ren Jun, Ting Liu, Tao Yi, Xia Zhao, Yu-Quan Wei, Xia-Wei Wei. Phosphatidylserine released from apoptotic cells in tumor induces M2-like macrophage polarization through the PSR-STAT3-JMJD3 axis. Cancer communications (London, England). 2022 03; 42(3):205-222. doi: 10.1002/cac2.12272. [PMID: 35191227]
  • Karla E Merz, Jinhee Hwang, Chunxue Zhou, Rajakrishnan Veluthakal, Erika M McCown, Angelica Hamilton, Eunjin Oh, Wenting Dai, Patrick T Fueger, Lei Jiang, Janice M Huss, Debbie C Thurmond. Enrichment of the exocytosis protein STX4 in skeletal muscle remediates peripheral insulin resistance and alters mitochondrial dynamics via Drp1. Nature communications. 2022 01; 13(1):424. doi: 10.1038/s41467-022-28061-w. [PMID: 35058456]
  • Danja J Den Hartogh, Filip Vlavcheski, Adria Giacca, Rebecca E K MacPherson, Evangelia Tsiani. Carnosic Acid Attenuates the Free Fatty Acid-Induced Insulin Resistance in Muscle Cells and Adipocytes. Cells. 2022 01; 11(1):. doi: 10.3390/cells11010167. [PMID: 35011728]
  • You Wang, Jinxian Yuan, Xinyuan Yu, Xi Liu, Changhong Tan, Yangmei Chen, Tao Xu. Vezatin regulates seizures by controlling AMPAR-mediated synaptic activity. Cell death & disease. 2021 10; 12(10):936. doi: 10.1038/s41419-021-04233-2. [PMID: 34642320]
  • Nicola Alesi, Elie W Akl, Damir Khabibullin, Heng-Jia Liu, Anna S Nidhiry, Emma R Garner, Harilaos Filippakis, Hilaire C Lam, Wei Shi, Srinivas R Viswanathan, Manrico Morroni, Shawn M Ferguson, Elizabeth P Henske. TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Nature communications. 2021 07; 12(1):4245. doi: 10.1038/s41467-021-24499-6. [PMID: 34253722]
  • Sakurako Hosotani, Shota Yamauchi, Haruki Kobayashi, Saashia Fuji, Shigekazu Koya, Ken-Ichiro Shimazaki, Atsushi Takemiya. A BLUS1 kinase signal and a decrease in intercellular CO2 concentration are necessary for stomatal opening in response to blue light. The Plant cell. 2021 07; 33(5):1813-1827. doi: 10.1093/plcell/koab067. [PMID: 33665670]
  • Shengnan Zhang, Yu-Qing Liu, Chunyu Jia, Yeh-Jun Lim, Guoqin Feng, Enquan Xu, Houfang Long, Yasuyoshi Kimura, Youqi Tao, Chunyu Zhao, Chuchu Wang, Zhenying Liu, Jin-Jian Hu, Meng-Rong Ma, Zhijun Liu, Lin Jiang, Dan Li, Renxiao Wang, Valina L Dawson, Ted M Dawson, Yan-Mei Li, Xiaobo Mao, Cong Liu. Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease. Proceedings of the National Academy of Sciences of the United States of America. 2021 06; 118(26):. doi: 10.1073/pnas.2011196118. [PMID: 34172566]
  • Zhigang Qu, Xiaochun Lu, Yan Qu, Tianqi Tao, Xiuhua Liu, Xiaoying Li. Attenuation of the upregulation of NF‑κB and AP‑1 DNA‑binding activities induced by tunicamycin or hypoxia/reoxygenation in neonatal rat cardiomyocytes by SERCA2a overexpression. International journal of molecular medicine. 2021 06; 47(6):. doi: 10.3892/ijmm.2021.4946. [PMID: 33907834]
  • Hideki Uedono, Katsuhito Mori, Akinobu Ochi, Shinya Nakatani, Yuya Miki, Akihiro Tsuda, Tomoaki Morioka, Yuki Nagata, Yasuo Imanishi, Tetsuo Shoji, Masaaki Inaba, Masanori Emoto. Effects of fetuin-A-containing calciprotein particles on posttranslational modifications of fetuin-A in HepG2 cells. Scientific reports. 2021 04; 11(1):7486. doi: 10.1038/s41598-021-86881-0. [PMID: 33820929]
  • Gyuhyeok Cho, Eunju Lee, Jungwook Kim. Structural insights into phosphatidylethanolamine formation in bacterial membrane biogenesis. Scientific reports. 2021 03; 11(1):5785. doi: 10.1038/s41598-021-85195-5. [PMID: 33707636]
  • Jiachang Wang, Yulong Ren, Xi Liu, Sheng Luo, Xiao Zhang, Xin Liu, Qibing Lin, Shanshan Zhu, Hua Wan, Yang Yang, Yu Zhang, Bin Lei, Chunlei Zhou, Tian Pan, Yongfei Wang, Mingming Wu, Ruonan Jing, Yang Xu, Meng Han, Fuqing Wu, Cailin Lei, Xiuping Guo, Zhijun Cheng, Xiaoming Zheng, Yihua Wang, Zhigang Zhao, Ling Jiang, Xin Zhang, Yong-Fei Wang, Haiyang Wang, Jianmin Wan. Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice. Molecular plant. 2021 02; 14(2):315-329. doi: 10.1016/j.molp.2020.11.022. [PMID: 33278597]
  • Yaqiu Hu, Hairong Zhao, Jiaming Lu, De Xie, Qiang Wang, Tianliang Huang, Hancheng Xin, Ichiro Hisatome, Tetsuya Yamamoto, Wei Wang, Jidong Cheng. High uric acid promotes dysfunction in pancreatic β cells by blocking IRS2/AKT signalling. Molecular and cellular endocrinology. 2021 01; 520(?):111070. doi: 10.1016/j.mce.2020.111070. [PMID: 33127482]
  • Xiao-Yi Lu, Xiong-Jie Shi, Ao Hu, Ju-Qiong Wang, Yi Ding, Wei Jiang, Ming Sun, Xiaolu Zhao, Jie Luo, Wei Qi, Bao-Liang Song. Feeding induces cholesterol biosynthesis via the mTORC1-USP20-HMGCR axis. Nature. 2020 12; 588(7838):479-484. doi: 10.1038/s41586-020-2928-y. [PMID: 33177714]
  • Yuichiro Kaibori, Kiriko Katayama, Yuka Tanaka, Masayoshi Ikeuchi, Mika Ogawa, Yuki Ikeda, Ryuzaburo Yuki, Youhei Saito, Yuji Nakayama. Kinase activity-independent role of EphA2 in the regulation of M-phase progression. Experimental cell research. 2020 10; 395(2):112207. doi: 10.1016/j.yexcr.2020.112207. [PMID: 32750331]
  • Sri Nagarjun Batchu, Veera Ganesh Yerra, Youan Liu, Suzanne L Advani, Thomas Klein, Andrew Advani. The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Directly Enhances the Contractile Recovery of Mouse Hearts at a Concentration Equivalent to that Achieved with Standard Dosing in Humans. International journal of molecular sciences. 2020 Aug; 21(16):. doi: 10.3390/ijms21165756. [PMID: 32796688]
  • Xue Zou, Meng-Yuan Liu, Wei-Hua Wu, Yang Wang. Phosphorylation at Ser28 stabilizes the Arabidopsis nitrate transporter NRT2.1 in response to nitrate limitation. Journal of integrative plant biology. 2020 Jun; 62(6):865-876. doi: 10.1111/jipb.12858. [PMID: 31342638]
  • Marianna Ranieri, Maria Venneri, Tommaso Pellegrino, Mariangela Centrone, Annarita Di Mise, Susanna Cotecchia, Grazia Tamma, Giovanna Valenti. The Vasopressin Receptor 2 Mutant R137L Linked to the Nephrogenic Syndrome of Inappropriate Antidiuresis (NSIAD) Signals through an Alternative Pathway that Increases AQP2 Membrane Targeting Independently of S256 Phosphorylation. Cells. 2020 05; 9(6):. doi: 10.3390/cells9061354. [PMID: 32486031]
  • Mu-Wen Chen, Han Zhu, Cai-Hong Xiong, Jia-Bing Li, Lan-Xue Zhao, Hong-Zhuan Chen, Yu Qiu. PKC and Ras are Involved in M1 Muscarinic Receptor-Mediated Modulation of AMPA Receptor GluA1 Subunit. Cellular and molecular neurobiology. 2020 May; 40(4):547-554. doi: 10.1007/s10571-019-00752-x. [PMID: 31721013]
  • Sachie Kimura, Kerri Hunter, Lauri Vaahtera, Huy Cuong Tran, Matteo Citterico, Aleksia Vaattovaara, Anne Rokka, Sara Christina Stolze, Anne Harzen, Lena Meißner, Maya Melina Tabea Wilkens, Thorsten Hamann, Masatsugu Toyota, Hirofumi Nakagami, Michael Wrzaczek. CRK2 and C-terminal Phosphorylation of NADPH Oxidase RBOHD Regulate Reactive Oxygen Species Production in Arabidopsis. The Plant cell. 2020 04; 32(4):1063-1080. doi: 10.1105/tpc.19.00525. [PMID: 32034035]
  • Tyson J Moyer, Yu Kato, Wuhbet Abraham, Jason Y H Chang, Daniel W Kulp, Nicki Watson, Hannah L Turner, Sergey Menis, Robert K Abbott, Jinal N Bhiman, Mariane B Melo, Hayley A Simon, Sara Herrera-De la Mata, Shu Liang, Gregory Seumois, Yash Agarwal, Na Li, Dennis R Burton, Andrew B Ward, William R Schief, Shane Crotty, Darrell J Irvine. Engineered immunogen binding to alum adjuvant enhances humoral immunity. Nature medicine. 2020 03; 26(3):430-440. doi: 10.1038/s41591-020-0753-3. [PMID: 32066977]
  • Chenyang Zhao, Jinlan Gao, Sen Li, Qi Liu, Xiaoyu Hou, Xuesha Xing, Danning Wang, Manni Sun, Shusen Wang, Yang Luo. Cyclin G2 regulates canonical Wnt signalling via interaction with Dapper1 to attenuate tubulointerstitial fibrosis in diabetic nephropathy. Journal of cellular and molecular medicine. 2020 03; 24(5):2749-2760. doi: 10.1111/jcmm.14946. [PMID: 31978940]
  • Yating Wang, Miaoqing Lu, Liping Xiong, Jinjin Fan, Yi Zhou, Huiyan Li, Xuan Peng, Zhong Zhong, Yihan Wang, Fengxian Huang, Wei Chen, Xueqing Yu, Haiping Mao. Drp1-mediated mitochondrial fission promotes renal fibroblast activation and fibrogenesis. Cell death & disease. 2020 01; 11(1):29. doi: 10.1038/s41419-019-2218-5. [PMID: 31949126]
  • Lalita Oparija-Rogenmozere, Anuradha Rajendran, Nadège Poncet, Simone M R Camargo, François Verrey. Phosphorylation of mouse intestinal basolateral amino acid uniporter LAT4 is controlled by food-entrained diurnal rhythm and dietary proteins. PloS one. 2020; 15(5):e0233863. doi: 10.1371/journal.pone.0233863. [PMID: 32470053]
  • Preeti Kumaran Menon, Niina Anneli Koistinen, Kerstin Iverfeldt, Anna-Lena Ström. Phosphorylation of the amyloid precursor protein (APP) at Ser-675 promotes APP processing involving meprin β. The Journal of biological chemistry. 2019 11; 294(47):17768-17776. doi: NULL. [PMID: 31604820]
  • Kristian Mark P Caldo, Yang Xu, Lucas Falarz, Kethmi Jayawardhane, Jeella Z Acedo, Guanqun Chen. Arabidopsis CTP:phosphocholine cytidylyltransferase 1 is phosphorylated and inhibited by sucrose nonfermenting 1-related protein kinase 1 (SnRK1). The Journal of biological chemistry. 2019 10; 294(43):15862-15874. doi: 10.1074/jbc.ra119.008047. [PMID: 31439667]
  • Yong-Bo Hu, Ru-Jing Ren, Yong-Fang Zhang, Yue Huang, Hai-Lun Cui, Chao Ma, Wen-Ying Qiu, Hao Wang, Pei-Jing Cui, Hong-Zhuan Chen, Gang Wang. Rho-associated coiled-coil kinase 1 activation mediates amyloid precursor protein site-specific Ser655 phosphorylation and triggers amyloid pathology. Aging cell. 2019 10; 18(5):e13001. doi: 10.1111/acel.13001. [PMID: 31287605]
  • Nina Oberbeck, Victoria C Pham, Joshua D Webster, Rohit Reja, Christine S Huang, Yue Zhang, Merone Roose-Girma, Søren Warming, Qingling Li, Andrew Birnberg, Weng Wong, Wendy Sandoval, László G Kőműves, Kebing Yu, Debra L Dugger, Allie Maltzman, Kim Newton, Vishva M Dixit. The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function. Nature. 2019 10; 574(7777):249-253. doi: 10.1038/s41586-019-1615-3. [PMID: 31578523]
  • Sumit Garg, Yangmingyue Liu, Ursula Perez-Salas, Lionel Porcar, Paul D Butler. Anomalous inter-membrane cholesterol transport in fluid phase phosphoserine vesicles driven by headgroup ordered to disordered entropic transition. Chemistry and physics of lipids. 2019 09; 223(?):104779. doi: 10.1016/j.chemphyslip.2019.05.004. [PMID: 31153912]
  • Eva Nora Bukosza, Tamás Kaucsár, Mária Godó, Enikő Lajtár, Pál Tod, Gábor Koncsos, Zoltán V Varga, Tamás Baranyai, Minh Tu Nguyen, Helga Schachner, Csaba Sőti, Péter Ferdinandy, Zoltán Giricz, Gábor Szénási, Péter Hamar. Glomerular Collagen Deposition and Lipocalin-2 Expression Are Early Signs of Renal Injury in Prediabetic Obese Rats. International journal of molecular sciences. 2019 08; 20(17):. doi: 10.3390/ijms20174266. [PMID: 31480394]
  • Yibo Liu, Juewen Liu. Growing a Nucleotide/Lanthanide Coordination Polymer Shell on Liposomes. Langmuir : the ACS journal of surfaces and colloids. 2019 08; 35(34):11217-11224. doi: 10.1021/acs.langmuir.9b00677. [PMID: 31379173]
  • Xiao Yu, Bo Li, Geng-Jen Jang, Shan Jiang, Daohong Jiang, Jyan-Chyun Jang, Shu-Hsing Wu, Libo Shan, Ping He. Orchestration of Processing Body Dynamics and mRNA Decay in Arabidopsis Immunity. Cell reports. 2019 08; 28(8):2194-2205.e6. doi: 10.1016/j.celrep.2019.07.054. [PMID: 31433992]
  • Jung-Woo Kang, Hyo-Sun Choi, Jun-Kyu Shin, Sun-Mee Lee. Resolvin D1 activates the sphingosine-1-phosphate signaling pathway in murine livers with ischemia/reperfusion injury. Biochemical and biophysical research communications. 2019 07; 514(4):1058-1065. doi: 10.1016/j.bbrc.2019.05.041. [PMID: 31097221]
  • R Ellis, M Katerelos, S W Choy, N Cook, M Lee, K Paizis, G Pell, S Walker, D A Power, P F Mount. Increased expression and phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoforms in urinary exosomes in pre-eclampsia. Journal of translational medicine. 2019 02; 17(1):60. doi: 10.1186/s12967-019-1806-6. [PMID: 30819197]
  • Rajendra Singh, Charlotte Stoneham, Christopher Lim, Xiaofei Jia, Javier Guenaga, Richard Wyatt, Joel O Wertheim, Yong Xiong, John Guatelli. Phosphoserine acidic cluster motifs bind distinct basic regions on the μ subunits of clathrin adaptor protein complexes. The Journal of biological chemistry. 2018 10; 293(40):15678-15690. doi: 10.1074/jbc.ra118.003080. [PMID: 30135209]
  • Chiye Sakurai, Makoto Itakura, Daiki Kinoshita, Seisuke Arai, Hitoshi Hashimoto, Ikuo Wada, Kiyotaka Hatsuzawa. Phosphorylation of SNAP-23 at Ser95 causes a structural alteration and negatively regulates Fc receptor-mediated phagosome formation and maturation in macrophages. Molecular biology of the cell. 2018 07; 29(13):1753-1762. doi: 10.1091/mbc.e17-08-0523. [PMID: 29771640]
  • Marie Rogne, Dinh-Toi Chu, Thomas M Küntziger, Maria-Niki Mylonakou, Philippe Collas, Kjetil Tasken. OPA1-anchored PKA phosphorylates perilipin 1 on S522 and S497 in adipocytes differentiated from human adipose stem cells. Molecular biology of the cell. 2018 06; 29(12):1487-1501. doi: 10.1091/mbc.e17-09-0538. [PMID: 29688805]
  • Xuan Zhang, Kai Dong, Kai Xu, Kun Zhang, Xuejiao Jin, Meng Yang, Yongliang Zhang, Xianbing Wang, Chenggui Han, Jialin Yu, Dawei Li. Barley stripe mosaic virus infection requires PKA-mediated phosphorylation of γb for suppression of both RNA silencing and the host cell death response. The New phytologist. 2018 06; 218(4):1570-1585. doi: 10.1111/nph.15065. [PMID: 29453938]
  • Makoto Kurano, Koichi Tsuneyama, Yuki Morimoto, Tomo Shimizu, Masahiro Jona, Hidetoshi Kassai, Kazuki Nakao, Atsu Aiba, Yutaka Yatomi. Apolipoprotein M Protects Lipopolysaccharide-Treated Mice from Death and Organ Injury. Thrombosis and haemostasis. 2018 06; 118(6):1021-1035. doi: 10.1055/s-0038-1641750. [PMID: 29669385]
  • Xiangxiu Liang, Miaomiao Ma, Zhaoyang Zhou, Jinlong Wang, Xinru Yang, Shaofei Rao, Guozhi Bi, Lin Li, Xiaojuan Zhang, Jijie Chai, She Chen, Jian-Min Zhou. Ligand-triggered de-repression of Arabidopsis heterotrimeric G proteins coupled to immune receptor kinases. Cell research. 2018 May; 28(5):529-543. doi: 10.1038/s41422-018-0027-5. [PMID: 29545645]
  • Li Ma, Kang Li, Yaxin Guo, Xiang Sun, Huimin Deng, Kai Li, Qili Feng, Sheng Li. Ras-Raf-MAPK signaling promotes nuclear localization of FOXA transcription factor SGF1 via Ser91 phosphorylation. Biochimica et biophysica acta. Molecular cell research. 2018 Apr; 1865(4):560-571. doi: 10.1016/j.bbamcr.2018.01.007. [PMID: 29355586]
  • Yoshitaka Kawa, Tatsuya Nagano, Asuka Yoshizaki, Ryota Dokuni, Masahiro Katsurada, Tomomi Terashita, Yuichiro Yasuda, Kanoko Umezawa, Masatsugu Yamamoto, Hiroshi Kamiryo, Kazuyuki Kobayashi, Yoshihiro Nishimura. Role of S1P/S1PR3 axis in release of CCL20 from human bronchial epithelial cells. PloS one. 2018; 13(9):e0203211. doi: 10.1371/journal.pone.0203211. [PMID: 30192865]
  • Ling-Yu Qiu, Guang-Ling Duan, Yu-Feng Yan, Yuan-Yuan Li, Huan Wang, Ling Xiao, Zhang-Ping Liao, He-Ping Chen. Sasanquasaponin induces increase of Cl‑/HCO3‑ exchange of anion exchanger 3 and promotes intracellular Cl‑ efflux in hypoxia/reoxygenation cardiomyocytes. Molecular medicine reports. 2017 Sep; 16(3):2953-2961. doi: 10.3892/mmr.2017.6882. [PMID: 28677776]
  • Yanhua Su, Shiliang Wang, Fei Zhang, Han Zheng, Yanan Liu, Tongtong Huang, Yong Ding. Phosphorylation of Histone H2A at Serine 95: A Plant-Specific Mark Involved in Flowering Time Regulation and H2A.Z Deposition. The Plant cell. 2017 Sep; 29(9):2197-2213. doi: 10.1105/tpc.17.00266. [PMID: 28790150]
  • Chun-Wei Yu, Ready Tai, Shen-Chi Wang, Ping Yang, Ming Luo, Songguang Yang, Kai Cheng, Wen-Chun Wang, Yi-Sheng Cheng, Keqiang Wu. HISTONE DEACETYLASE6 Acts in Concert with Histone Methyltransferases SUVH4, SUVH5, and SUVH6 to Regulate Transposon Silencing. The Plant cell. 2017 Aug; 29(8):1970-1983. doi: 10.1105/tpc.16.00570. [PMID: 28778955]
  • Charlotte A Stoneham, Rajendra Singh, Xiaofei Jia, Yong Xiong, John Guatelli. Endocytic activity of HIV-1 Vpu: Phosphoserine-dependent interactions with clathrin adaptors. Traffic (Copenhagen, Denmark). 2017 08; 18(8):545-561. doi: 10.1111/tra.12495. [PMID: 28504462]
  • Misa Sayama, Asuka Inoue, Sho Nakamura, Sejin Jung, Masaya Ikubo, Yuko Otani, Akiharu Uwamizu, Takayuki Kishi, Kumiko Makide, Junken Aoki, Takatsugu Hirokawa, Tomohiko Ohwada. Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1 by Docking-Aided Structure-Activity Analysis. Journal of medicinal chemistry. 2017 07; 60(14):6384-6399. doi: 10.1021/acs.jmedchem.7b00693. [PMID: 28715213]
  • Mengmeng Zhu, Tong Zhang, Wei Ji, Cecilia Silva-Sanchez, Wen-Yuan Song, Sarah M Assmann, Alice C Harmon, Sixue Chen. Redox regulation of a guard cell SNF1-related protein kinase in Brassica napus, an oilseed crop. The Biochemical journal. 2017 07; 474(15):2585-2599. doi: 10.1042/bcj20170070. [PMID: 28642254]
  • Sheng Ying, Allyson T Hill, Michal Pyc, Erin M Anderson, Wayne A Snedden, Robert T Mullen, Yi-Min She, William C Plaxton. Regulatory Phosphorylation of Bacterial-Type PEP Carboxylase by the Ca2+-Dependent Protein Kinase RcCDPK1 in Developing Castor Oil Seeds. Plant physiology. 2017 Jun; 174(2):1012-1027. doi: 10.1104/pp.17.00288. [PMID: 28363991]
  • Sibel Büyüktiryaki, Rıdvan Say, Adil Denizli, Arzu Ersöz. Phosphoserine imprinted nanosensor for detection of Cancer Antigen 125. Talanta. 2017 May; 167(?):172-180. doi: 10.1016/j.talanta.2017.01.093. [PMID: 28340708]
  • Qing Liu, Qin Wang, Weixian Deng, Xu Wang, Mingxin Piao, Dawei Cai, Yaxing Li, William D Barshop, Xiaolan Yu, Tingting Zhou, Bin Liu, Yoshito Oka, James Wohlschlegel, Zecheng Zuo, Chentao Lin. Molecular basis for blue light-dependent phosphorylation of Arabidopsis cryptochrome 2. Nature communications. 2017 05; 8(?):15234. doi: 10.1038/ncomms15234. [PMID: 28492234]
  • Rachael P Norris, Valentina Baena, Mark Terasaki. Localization of phosphorylated connexin 43 using serial section immunogold electron microscopy. Journal of cell science. 2017 04; 130(7):1333-1340. doi: 10.1242/jcs.198408. [PMID: 28202692]
  • Françoise M Roelants, Kristin L Leskoske, Ross T A Pedersen, Alexander Muir, Jeffrey M-H Liu, Gregory C Finnigan, Jeremy Thorner. TOR Complex 2-Regulated Protein Kinase Fpk1 Stimulates Endocytosis via Inhibition of Ark1/Prk1-Related Protein Kinase Akl1 in Saccharomyces cerevisiae. Molecular and cellular biology. 2017 04; 37(7):. doi: 10.1128/mcb.00627-16. [PMID: 28069741]
  • Silvia Vega-Rubin-de-Celis, Samuel Peña-Llopis, Meghan Konda, James Brugarolas. Multistep regulation of TFEB by MTORC1. Autophagy. 2017 Mar; 13(3):464-472. doi: 10.1080/15548627.2016.1271514. [PMID: 28055300]
  • Xi Ma, Shen Zhang, Long He, Yueguang Rong, Livia Wilz Brier, Qiming Sun, Rong Liu, Weiliang Fan, She Chen, Zhenyu Yue, Joungmok Kim, Kun-Liang Guan, Defa Li, Qing Zhong. MTORC1-mediated NRBF2 phosphorylation functions as a switch for the class III PtdIns3K and autophagy. Autophagy. 2017 Mar; 13(3):592-607. doi: 10.1080/15548627.2016.1269988. [PMID: 28059666]
  • Abul Arif, Fulvia Terenzi, Alka A Potdar, Jie Jia, Jessica Sacks, Arnab China, Dalia Halawani, Kommireddy Vasu, Xiaoxia Li, J Mark Brown, Jie Chen, Sara C Kozma, George Thomas, Paul L Fox. EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice. Nature. 2017 02; 542(7641):357-361. doi: 10.1038/nature21380. [PMID: 28178239]
  • Yue Zhang, Xiang Gao, Shuanggang Chen, Min Zhao, Jing Chen, Rui Liu, Shengyang Cheng, Mengyuan Qi, Shuo Wang, Wei Liu. Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy. Cellular signalling. 2017 02; 31(?):31-40. doi: 10.1016/j.cellsig.2016.12.009. [PMID: 28024901]
  • Maria Castañeda-Bueno, Juan Pablo Arroyo, Junhui Zhang, Jeremy Puthumana, Orlando Yarborough, Shigeru Shibata, Lorena Rojas-Vega, Gerardo Gamba, Jesse Rinehart, Richard P Lifton. Phosphorylation by PKC and PKA regulate the kinase activity and downstream signaling of WNK4. Proceedings of the National Academy of Sciences of the United States of America. 2017 01; 114(5):E879-E886. doi: 10.1073/pnas.1620315114. [PMID: 28096417]
  • Yang Lu, Wenlong Ma, Zhongwei Li, Jun Lu, Xiuli Wang. The interplay between p16 serine phosphorylation and arginine methylation determines its function in modulating cellular apoptosis and senescence. Scientific reports. 2017 01; 7(?):41390. doi: 10.1038/srep41390. [PMID: 28120917]
  • Mònica Pons, Ismael Izquierdo, Mireia Andreu-Carbó, Georgina Garrido, Jesús Planagumà, Olivia Muriel, Miguel A Del Pozo, M Isabel Geli, Anna M Aragay. Phosphorylation of filamin A regulates chemokine receptor CCR2 recycling. Journal of cell science. 2017 01; 130(2):490-501. doi: 10.1242/jcs.193821. [PMID: 27909248]
  • Mohammed M Nooh, Suleiman W Bahouth. Two barcodes encoded by the type-1 PDZ and by phospho-Ser312 regulate retromer/WASH-mediated sorting of the ß1-adrenergic receptor from endosomes to the plasma membrane. Cellular signalling. 2017 01; 29(?):192-208. doi: 10.1016/j.cellsig.2016.10.014. [PMID: 27816670]
  • Katharina Modde, Stefan Timm, Alexandra Florian, Klaudia Michl, Alisdair R Fernie, Hermann Bauwe. High serine:glyoxylate aminotransferase activity lowers leaf daytime serine levels, inducing the phosphoserine pathway in Arabidopsis. Journal of experimental botany. 2017 01; 68(3):643-656. doi: 10.1093/jxb/erw467. [PMID: 28011718]
  • Fumiaki Ando, Eisei Sohara, Tetsuji Morimoto, Naofumi Yui, Naohiro Nomura, Eriko Kikuchi, Daiei Takahashi, Takayasu Mori, Alain Vandewalle, Tatemitsu Rai, Sei Sasaki, Yoshiaki Kondo, Shinichi Uchida. Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway. Nature communications. 2016 11; 7(?):13636. doi: 10.1038/ncomms13636. [PMID: 27892464]
  • Andreas Sven Richter, Caroline Hochheuser, Christian Fufezan, Laura Heinze, Franziska Kuhnert, Bernhard Grimm. Phosphorylation of GENOMES UNCOUPLED 4 Alters Stimulation of Mg Chelatase Activity in Angiosperms. Plant physiology. 2016 11; 172(3):1578-1595. doi: 10.1104/pp.16.01036. [PMID: 27688621]
  • Samantha M Logan, Kenneth B Storey. Tissue-specific response of carbohydrate-responsive element binding protein (ChREBP) to mammalian hibernation in 13-lined ground squirrels. Cryobiology. 2016 10; 73(2):103-11. doi: 10.1016/j.cryobiol.2016.09.002. [PMID: 27614289]
  • Lewis J Watson, Kevin M Alexander, Maradumane L Mohan, Amber L Bowman, Supachoke Mangmool, Kunhong Xiao, Sathyamangla V Naga Prasad, Howard A Rockman. Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation. Cellular signalling. 2016 10; 28(10):1580-92. doi: 10.1016/j.cellsig.2016.05.006. [PMID: 27169346]
  • Susumu Tanimura, Junya Hashizume, Naoya Arichika, Kazushi Watanabe, Kaname Ohyama, Kohsuke Takeda, Michiaki Kohno. ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips. The Journal of cell biology. 2016 08; 214(4):475-89. doi: 10.1083/jcb.201503123. [PMID: 27502487]
  • Lisa M Yates, Dorothea Fiedler. A Stable Pyrophosphoserine Analog for Incorporation into Peptides and Proteins. ACS chemical biology. 2016 Apr; 11(4):1066-73. doi: 10.1021/acschembio.5b00972. [PMID: 26760216]
  • Pooja Singhmar, XiaoJiao Huo, Niels Eijkelkamp, Susana Rojo Berciano, Faiza Baameur, Fang C Mei, Yingmin Zhu, Xiaodong Cheng, David Hawke, Federico Mayor, Cristina Murga, Cobi J Heijnen, Annemieke Kavelaars. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proceedings of the National Academy of Sciences of the United States of America. 2016 Mar; 113(11):3036-41. doi: 10.1073/pnas.1516036113. [PMID: 26929333]
  • Baowen Zhang, Xiaolong Wang, Zhiying Zhao, Ruiju Wang, Xiahe Huang, Yali Zhu, Li Yuan, Yingchun Wang, Xiaodong Xu, Alma L Burlingame, Yingjie Gao, Yu Sun, Wenqiang Tang. OsBRI1 Activates BR Signaling by Preventing Binding between the TPR and Kinase Domains of OsBSK3 via Phosphorylation. Plant physiology. 2016 Feb; 170(2):1149-61. doi: 10.1104/pp.15.01668. [PMID: 26697897]
  • Lori Borgal, Markus M Rinschen, Claudia Dafinger, Valérie I Liebrecht, Hinrich Abken, Thomas Benzing, Bernhard Schermer. Jade-1S phosphorylation induced by CK1α contributes to cell cycle progression. Cell cycle (Georgetown, Tex.). 2016; 15(8):1034-45. doi: 10.1080/15384101.2016.1152429. [PMID: 26919559]
  • Murat Gulsun, Taner Oznur, Emre Aydemir, Fatih Ozcelik, Murat Erdem, Serkan Zincir, Ozgur Akgul, Yasemin Kurt. Possible relationship between amino acids, aggression and psychopathy. International journal of psychiatry in clinical practice. 2016; 20(2):91-100. doi: 10.3109/13651501.2016.1144771. [PMID: 26982638]
  • Xiao-Qian Fang, Haifa Qiao, Bradley R Groveman, Shuang Feng, Melissa Pflueger, Wen-Kuan Xin, Mohammad K Ali, Shuang-Xiu Lin, Jindong Xu, Florian Duclot, Mohamed Kabbaj, Wei Wang, Xin-Sheng Ding, Teresa Santiago-Sim, Xing-Hong Jiang, Michael W Salter, Xian-Min Yu. Regulated internalization of NMDA receptors drives PKD1-mediated suppression of the activity of residual cell-surface NMDA receptors. Molecular brain. 2015 Nov; 8(1):75. doi: 10.1186/s13041-015-0167-1. [PMID: 26584860]
  • Jing Chen, Sudhirkumar Shinde, Markus-Hermann Koch, Martin Eisenacher, Sara Galozzi, Thilo Lerari, Katalin Barkovits, Prabal Subedi, Rejko Krüger, Katja Kuhlmann, Börje Sellergren, Stefan Helling, Katrin Marcus. Low-bias phosphopeptide enrichment from scarce samples using plastic antibodies. Scientific reports. 2015 Jul; 5(?):11438. doi: 10.1038/srep11438. [PMID: 26126808]
  • Alexandre Grondin, Olivier Rodrigues, Lionel Verdoucq, Sylvain Merlot, Nathalie Leonhardt, Christophe Maurel. Aquaporins Contribute to ABA-Triggered Stomatal Closure through OST1-Mediated Phosphorylation. The Plant cell. 2015 Jul; 27(7):1945-54. doi: 10.1105/tpc.15.00421. [PMID: 26163575]
  • Marianna Ranieri, Grazia Tamma, Annarita Di Mise, Annamaria Russo, Mariangela Centrone, Maria Svelto, Giuseppe Calamita, Giovanna Valenti. Negative feedback from CaSR signaling to aquaporin-2 sensitizes vasopressin to extracellular Ca2. Journal of cell science. 2015 Jul; 128(13):2350-60. doi: 10.1242/jcs.168096. [PMID: 25977473]
  • Xiaona Zhou, Hongmei Hao, Yuguo Zhang, Yili Bai, Wenbo Zhu, Yunxia Qin, Feifei Yuan, Feiyi Zhao, Mengyao Wang, Jingjiang Hu, Hong Xu, Aiguang Guo, Huixian Zhao, Yang Zhao, Cuiling Cao, Yongqing Yang, Karen S Schumaker, Yan Guo, Chang Gen Xie. SOS2-LIKE PROTEIN KINASE5, an SNF1-RELATED PROTEIN KINASE3-Type Protein Kinase, Is Important for Abscisic Acid Responses in Arabidopsis through Phosphorylation of ABSCISIC ACID-INSENSITIVE5. Plant physiology. 2015 Jun; 168(2):659-76. doi: 10.1104/pp.114.255455. [PMID: 25858916]
  • Friederike Klemke, Antje Baier, Henning Knoop, Ramona Kern, Jiri Jablonsky, Gabriele Beyer, Thomas Volkmer, Ralf Steuer, Wolfgang Lockau, Martin Hagemann. Identification of the light-independent phosphoserine pathway as an additional source of serine in the cyanobacterium Synechocystis sp. PCC 6803. Microbiology (Reading, England). 2015 May; 161(Pt 5):1050-1060. doi: 10.1099/mic.0.000055. [PMID: 25701735]
  • Michael P Whyte, Amanda Blythe, William H McAlister, Angela R Nenninger, Vinieth N Bijanki, Steven Mumm. Lenz-Majewski hyperostotic dwarfism with hyperphosphoserinuria from a novel mutation in PTDSS1 encoding phosphatidylserine synthase 1. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015 Apr; 30(4):606-14. doi: 10.1002/jbmr.2398. [PMID: 25363158]
  • Shanshan Gao, Weimin Liu, Xiaozhen Zhuo, Lijun Wang, Gang Wang, Tao Sun, Zhao Zhao, Junhui Liu, Yuling Tian, Juan Zhou, Zuyi Yuan, Yue Wu. The activation of mTOR is required for monocyte pro-inflammatory response in patients with coronary artery disease. Clinical science (London, England : 1979). 2015 Apr; 128(8):517-26. doi: 10.1042/cs20140427. [PMID: 25428582]
  • Tarek Hewezi, Parijat S Juvale, Sarbottam Piya, Tom R Maier, Aditi Rambani, J Hollis Rice, Melissa G Mitchum, Eric L Davis, Richard S Hussey, Thomas J Baum. The cyst nematode effector protein 10A07 targets and recruits host posttranslational machinery to mediate its nuclear trafficking and to promote parasitism in Arabidopsis. The Plant cell. 2015 Mar; 27(3):891-907. doi: 10.1105/tpc.114.135327. [PMID: 25715285]
  • Sining Kang, Fan Yang, Lin Li, Huamin Chen, She Chen, Jie Zhang. The Arabidopsis transcription factor BRASSINOSTEROID INSENSITIVE1-ETHYL METHANESULFONATE-SUPPRESSOR1 is a direct substrate of MITOGEN-ACTIVATED PROTEIN KINASE6 and regulates immunity. Plant physiology. 2015 Mar; 167(3):1076-86. doi: 10.1104/pp.114.250985. [PMID: 25609555]
  • Masayuki Muramatsu, Rintaro Suzuki, Toshimasa Yamazaki, Mitsue Miyao. Comparison of plant-type phosphoenolpyruvate carboxylases from rice: identification of two plant-specific regulatory regions of the allosteric enzyme. Plant & cell physiology. 2015 Mar; 56(3):468-80. doi: 10.1093/pcp/pcu189. [PMID: 25505033]
  • Anas M Fathallah, Michael R Turner, Donald E Mager, Sathy V Balu-Iyer. Effects of hypertonic buffer composition on lymph node uptake and bioavailability of rituximab, after subcutaneous administration. Biopharmaceutics & drug disposition. 2015 Mar; 36(2):115-25. doi: 10.1002/bdd.1925. [PMID: 25377184]
  • Daniela Ernst, Sinéad M Murphy, Karthik Sathiyanadan, Yu Wei, Alaa Othman, Matilde Laurá, Yo-Tsen Liu, Anke Penno, Julian Blake, Michael Donaghy, Henry Houlden, Mary M Reilly, Thorsten Hornemann. Novel HSAN1 mutation in serine palmitoyltransferase resides at a putative phosphorylation site that is involved in regulating substrate specificity. Neuromolecular medicine. 2015 Mar; 17(1):47-57. doi: 10.1007/s12017-014-8339-1. [PMID: 25567748]
  • Yoshinori Mine, Denise Young, Chengbo Yang. Antioxidative stress effect of phosphoserine dimers is mediated via activation of the Nrf2 signaling pathway. Molecular nutrition & food research. 2015 Feb; 59(2):303-14. doi: 10.1002/mnfr.201400381. [PMID: 25351664]
  • Daisuke Urano, Olaf Czarnecki, Xiaoping Wang, Alan M Jones, Jin-Gui Chen. Arabidopsis receptor of activated C kinase1 phosphorylation by WITH NO LYSINE8 KINASE. Plant physiology. 2015 Feb; 167(2):507-16. doi: 10.1104/pp.114.247460. [PMID: 25489024]
  • Alexandr Prokhorov, Bernhard F Gibbs, Marco Bardelli, Laura Rüegg, Elizaveta Fasler-Kan, Luca Varani, Vadim V Sumbayev. The immune receptor Tim-3 mediates activation of PI3 kinase/mTOR and HIF-1 pathways in human myeloid leukaemia cells. The international journal of biochemistry & cell biology. 2015 Feb; 59(?):11-20. doi: 10.1016/j.biocel.2014.11.017. [PMID: 25483439]
  • Emily M Curtis, Xingqing Xiao, Stavroula Sofou, Carol K Hall. Phase separation behavior of mixed lipid systems at neutral and low pH: coarse-grained simulations with DMD/LIME. Langmuir : the ACS journal of surfaces and colloids. 2015 Jan; 31(3):1086-94. doi: 10.1021/la504082x. [PMID: 25549801]
  • Nadia Martinez-Martin, Abel Viejo-Borbolla, Rocío Martín, Soledad Blanco, Jeffrey L Benovic, Marcus Thelen, Antonio Alcamí. Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. Nature communications. 2015 Jan; 6(?):6163. doi: 10.1038/ncomms7163. [PMID: 25625471]
  • Puneet Gaitonde, Vivek S Purohit, Sathy V Balu-Iyer. Intravenous administration of Factor VIII-O-Phospho-L-Serine (OPLS) complex reduces immunogenicity and preserves pharmacokinetics of the therapeutic protein. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2015 Jan; 66(?):157-62. doi: 10.1016/j.ejps.2014.10.010. [PMID: 25459532]
  • Xiaomiao Zhao, Xueliang Tang, Tingting Ma, Miao Ding, Lijuan Bian, Dongmei Chen, Yangzhi Li, Liangan Wang, Yanyan Zhuang, Meiqing Xie, Dongzi Yang. Levonorgestrel Inhibits Human Endometrial Cell Proliferation through the Upregulation of Gap Junctional Intercellular Communication via the Nuclear Translocation of Ser255 Phosphorylated Cx43. BioMed research international. 2015; 2015(?):758684. doi: 10.1155/2015/758684. [PMID: 26161412]
  • Ping Zeng, Bin Liu, Qun Wang, Qin Fan, Jian-Xin Diao, Jing Tang, Xiu-Qiong Fu, Xue-Gang Sun. Apigenin Attenuates Atherogenesis through Inducing Macrophage Apoptosis via Inhibition of AKT Ser473 Phosphorylation and Downregulation of Plasminogen Activator Inhibitor-2. Oxidative medicine and cellular longevity. 2015; 2015(?):379538. doi: 10.1155/2015/379538. [PMID: 25960827]
  • Yamina Belabassi, Chih-Kai Chao, Ryan Holly, Kathleen M George, Jon O Nagy, Charles M Thompson. Preparation and characterization of diethoxy- and monoethoxy phosphylated ('aged') serine haptens and use in the production of monoclonal antibodies. Chemico-biological interactions. 2014 Nov; 223(?):134-40. doi: 10.1016/j.cbi.2014.09.010. [PMID: 25261769]
  • Shigeru Shibata, Juan Pablo Arroyo, María Castañeda-Bueno, Jeremy Puthumana, Junhui Zhang, Shunya Uchida, Kathryn L Stone, TuKiet T Lam, Richard P Lifton. Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation. Proceedings of the National Academy of Sciences of the United States of America. 2014 Oct; 111(43):15556-61. doi: 10.1073/pnas.1418342111. [PMID: 25313067]