compactin (BioDeep_00000003142)

Main id: BioDeep_00000399728

 

PANOMIX_OTCML-2023 Chemicals and Drugs


代谢物信息卡片


2S-methyl-(1S,2,3,7S,8S,8aR)-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2-H-pyran-2-yl]ethyl]-1-naphthalenyl ester-butanoic acid

化学式: C23H34O5 (390.24061140000003)
中文名称: 美伐他汀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
InChI: InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1

描述信息

A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group. A hydroxymethylglutaryl-CoA reductase inhibitor (statin) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents > D000924 - Anticholesteremic Agents
D004791 - Enzyme Inhibitors > D019161 - Hydroxymethylglutaryl-CoA Reductase Inhibitors
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C471 - Enzyme Inhibitor > C1655 - HMG-CoA Reductase Inhibitor
D009676 - Noxae > D000963 - Antimetabolites
Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G0/G1 phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment[1][2][3].
Mevastatin (Compactin) is a first HMG-CoA reductase inhibitor that belongs to the statins class. Mevastatin is a lipid-lowering agent, and induces apoptosis, arrests cancer cells in G0/G1 phase. Mevastatin also increases endothelial nitric oxide synthase (eNOS) mRNA and protein levels. Mevastatin has antitumor activity and has the potential for cardiovascular diseases treatment[1][2][3].

同义名列表

6 个代谢物同义名

Mevastatin; compactin; ML-236B; 2S-methyl-(1S,2,3,7S,8S,8aR)-hexahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2-H-pyran-2-yl]ethyl]-1-naphthalenyl ester-butanoic acid; [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate; ML236B



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

22 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alexander C Pfotenhauer, D Nikki Reuter, Mikayla Clark, Stacee A Harbison, Tayler M Schimel, C Neal Stewart, Scott C Lenaghan. Development of new binary expression systems for plant synthetic biology. Plant cell reports. 2023 Dec; 43(1):22. doi: 10.1007/s00299-023-03100-y. [PMID: 38150091]
  • Lai Wang, Zu-Guo Zheng, Lingchang Meng, Lijun Zhu, Ping Li, Jun Chen, Hua Yang. Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue. Cell biology and toxicology. 2021 06; 37(3):441-460. doi: 10.1007/s10565-020-09558-w. [PMID: 33034787]
  • Aaser M Abdelazim, Tamer Ahmed Ismail, Mosleh M Abumaghaid, Islam M Saadaldin. Synergetic Action of Forskolin and Mevastatin Induce Normalization of Lipids Profile in Dyslipidemic Rats through Adenosine Monophosphate Kinase Upregulation. BioMed research international. 2021; 2021(?):6687551. doi: 10.1155/2021/6687551. [PMID: 34104650]
  • Chuen-Mao Yang, Chih-Chung Lin, Chien-Chung Yang, Rou-Ling Cho, Li-Der Hsiao. Mevastatin-Induced AP-1-Dependent HO-1 Expression Suppresses Vascular Cell Adhesion Molecule-1 Expression and Monocyte Adhesion on Human Pulmonary Alveolar Epithelial Cells Challenged with TNF-α. Biomolecules. 2020 03; 10(3):. doi: 10.3390/biom10030381. [PMID: 32121588]
  • Katrine Bjune, Hilde Sundvold, Trond P Leren, Soheil Naderi. MK-2206, an allosteric inhibitor of AKT, stimulates LDLR expression and LDL uptake: A potential hypocholesterolemic agent. Atherosclerosis. 2018 09; 276(?):28-38. doi: 10.1016/j.atherosclerosis.2018.07.009. [PMID: 30025252]
  • Zhaohu Lin, Zhuqing Zhang, Xiaoxiao Jiang, Xinhui Kou, Yong Bao, Huijuan Liu, Fanghui Sun, Shuang Ling, Ning Qin, Lan Jiang, Yonghua Yang. Mevastatin blockade of autolysosome maturation stimulates LBH589-induced cell death in triple-negative breast cancer cells. Oncotarget. 2017 Mar; 8(11):17833-17848. doi: 10.18632/oncotarget.14868. [PMID: 28147319]
  • Yongbin Lu, Zhiyuan Cheng, Yaxue Zhao, Xiaoyu Chang, Cynthia Chan, Yana Bai, Ning Cheng. Efficacy and safety of long-term treatment with statins for coronary heart disease: A Bayesian network meta-analysis. Atherosclerosis. 2016 11; 254(?):215-227. doi: 10.1016/j.atherosclerosis.2016.10.025. [PMID: 27764723]
  • Aurélie Thedrez, Barbara Sjouke, Maxime Passard, Simon Prampart-Fauvet, Alexis Guédon, Mikael Croyal, Geesje Dallinga-Thie, Jorge Peter, Dirk Blom, Milco Ciccarese, Angelo B Cefalù, Livia Pisciotta, Raul D Santos, Maurizio Averna, Frederick Raal, Paolo Pintus, Maria Cossu, Kees Hovingh, Gilles Lambert. Proprotein Convertase Subtilisin Kexin Type 9 Inhibition for Autosomal Recessive Hypercholesterolemia-Brief Report. Arteriosclerosis, thrombosis, and vascular biology. 2016 08; 36(8):1647-50. doi: 10.1161/atvbaha.116.307493. [PMID: 27079874]
  • Neeradi Dinesh, Neelagiri Soumya, Sushma Singh. Antileishmanial effect of mevastatin is due to interference with sterol metabolism. Parasitology research. 2015 Oct; 114(10):3873-83. doi: 10.1007/s00436-015-4618-5. [PMID: 26183607]
  • Tobias Hilbert, Jens Poth, Stilla Frede, Sven Klaschik, Andreas Hoeft, Georg Baumgarten, Pascal Knuefermann. Anti-atherogenic effects of statins: Impact on angiopoietin-2 release from endothelial cells. Biochemical pharmacology. 2013 Nov; 86(10):1452-60. doi: 10.1016/j.bcp.2013.09.004. [PMID: 24041741]
  • Guangzhong Ma, Junyu Zhou, Chunxiu Tian, Dechen Jiang, Danjun Fang, Hongyuan Chen. Luminol electrochemiluminescence for the analysis of active cholesterol at the plasma membrane in single mammalian cells. Analytical chemistry. 2013 Apr; 85(8):3912-7. doi: 10.1021/ac303304r. [PMID: 23527944]
  • Gabriela Soto, Margarita Stritzler, Christian Lisi, Karina Alleva, María Elba Pagano, Fernando Ardila, Matteo Mozzicafreddo, Massimiliano Cuccioloni, Mauro Angeletti, Nicolás Daniel Ayub. Acetoacetyl-CoA thiolase regulates the mevalonate pathway during abiotic stress adaptation. Journal of experimental botany. 2011 Nov; 62(15):5699-711. doi: 10.1093/jxb/err287. [PMID: 21908473]
  • Tsuyoshi Furumoto, Teppei Yamaguchi, Yumiko Ohshima-Ichie, Masayoshi Nakamura, Yoshiko Tsuchida-Iwata, Masaki Shimamura, Junichi Ohnishi, Shingo Hata, Udo Gowik, Peter Westhoff, Andrea Bräutigam, Andreas P M Weber, Katsura Izui. A plastidial sodium-dependent pyruvate transporter. Nature. 2011 Aug; 476(7361):472-5. doi: 10.1038/nature10250. [PMID: 21866161]
  • Andrey Y Abramov, Maksim Ionov, Evgeny Pavlov, Michael R Duchen. Membrane cholesterol content plays a key role in the neurotoxicity of β-amyloid: implications for Alzheimer's disease. Aging cell. 2011 Aug; 10(4):595-603. doi: 10.1111/j.1474-9726.2011.00685.x. [PMID: 21332922]
  • Alexandra Madeira, Junfeng Yang, Xiaoqun Zhang, Elisabet Vikeved, Anna Nilsson, Per E Andrén, Per Svenningsson. Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression. Neurochemistry international. 2011 Aug; 59(2):280-9. doi: 10.1016/j.neuint.2011.05.017. [PMID: 21693152]
  • José O Colón-Sáez, Jerrel L Yakel. The α7 nicotinic acetylcholine receptor function in hippocampal neurons is regulated by the lipid composition of the plasma membrane. The Journal of physiology. 2011 Jul; 589(Pt 13):3163-74. doi: 10.1113/jphysiol.2011.209494. [PMID: 21540349]
  • Chia-Che Chang, Wei-Chuan Chen, Tsing-Fen Ho, Ho-Shing Wu, Yu-Hong Wei. Development of natural anti-tumor drugs by microorganisms. Journal of bioscience and bioengineering. 2011 May; 111(5):501-11. doi: 10.1016/j.jbiosc.2010.12.026. [PMID: 21277252]
  • Ruei-Lan Tsai, Bing-Ying Ho, Tzu-Ming Pan. Red Mold Rice Mitigates Oral Carcinogenesis in 7,12-Dimethyl-1,2-Benz[a]anthracene-Induced Oral Carcinogenesis in Hamster. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):245209. doi: 10.1093/ecam/nep215. [PMID: 20019075]
  • Valentina De Chiara, Francesco Angelucci, Silvia Rossi, Alessandra Musella, Francesca Cavasinni, Cristina Cantarella, Giorgia Mataluni, Lucia Sacchetti, Francesco Napolitano, Maura Castelli, Carlo Caltagirone, Giorgio Bernardi, Mauro Maccarrone, Alessandro Usiello, Diego Centonze. Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2010 Jun; 30(24):8127-37. doi: 10.1523/jneurosci.1683-10.2010. [PMID: 20554863]
  • Luca Pugliese, Ilaria Bernardini, Nazareno Pacifico, Manola Peverini, Eleni Damaskopoulou, Samuela Cataldi, Elisabetta Albi. Severe hypocholesterolaemia is often neglected in haematological malignancies. European journal of cancer (Oxford, England : 1990). 2010 Jun; 46(9):1735-43. doi: 10.1016/j.ejca.2010.03.041. [PMID: 20434328]
  • Danjun Fang, Richard H West, Mary E Manson, Jennifer Ruddy, Dechen Jiang, Stephen F Previs, Nitin D Sonawane, James D Burgess, Thomas J Kelley. Increased plasma membrane cholesterol in cystic fibrosis cells correlates with CFTR genotype and depends on de novo cholesterol synthesis. Respiratory research. 2010 May; 11(?):61. doi: 10.1186/1465-9921-11-61. [PMID: 20487541]
  • Paul Targett-Adams, Steeve Boulant, Mark W Douglas, John McLauchlan. Lipid metabolism and HCV infection. Viruses. 2010 May; 2(5):1195-1217. doi: 10.3390/v2051195. [PMID: 21994676]
  • Menno Vergeer, Liam R Brunham, Joris Koetsveld, Janine K Kruit, C Bruce Verchere, John J P Kastelein, Michael R Hayden, Erik S G Stroes. Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction. Diabetes care. 2010 Apr; 33(4):869-74. doi: 10.2337/dc09-1562. [PMID: 20067955]
  • Masaki Sugazaki, Hiroaki Hirotani, Seishi Echigo, Sadaaki Takeyama, Hisashi Shinoda. Effects of mevastatin on grafted bone in MRL/MpJ mice. Connective tissue research. 2010 Apr; 51(2):105-12. doi: 10.3109/03008200903105098. [PMID: 20109072]
  • Guifen Liu, Haichao Lin, Jinlian Fu, Aiguo Wang. Effect of simvastatin on culturing of kidney cells from pigs in vitro. Molecular biology reports. 2010 Mar; 37(3):1391-5. doi: 10.1007/s11033-009-9522-6. [PMID: 19343539]
  • Anna Linetti, Alessandra Fratangeli, Elena Taverna, Pamela Valnegri, Maura Francolini, Valentina Cappello, Michela Matteoli, Maria Passafaro, Patrizia Rosa. Cholesterol reduction impairs exocytosis of synaptic vesicles. Journal of cell science. 2010 Feb; 123(Pt 4):595-605. doi: 10.1242/jcs.060681. [PMID: 20103534]
  • Maria Elephteria Evangelopoulos, Stefan Wüller, Joachim Weis, Alexander Krüttgen. A role of nitric oxide in neurite outgrowth of neuroblastoma cells triggered by mevastatin or serum reduction. Neuroscience letters. 2010 Jan; 468(1):28-33. doi: 10.1016/j.neulet.2009.10.054. [PMID: 19853642]
  • Dimitrios Kirmizis, Dimitrios Chatzidimitriou. Pleiotropic vasoprotective effects of statins: the chicken or the egg?. Drug design, development and therapy. 2009 Sep; 3(?):191-204. doi: 10.2147/dddt.s5407. [PMID: 19920934]
  • M E Evangelopoulos, J Weis, A Krüttgen. Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR. Journal of neuroscience research. 2009 Jul; 87(9):2138-44. doi: 10.1002/jnr.22025. [PMID: 19224573]
  • Carla Maria P Ribeiro, Harry Hurd, Yichao Wu, Mary E B Martino, Lisa Jones, Brian Brighton, Richard C Boucher, Wanda K O'Neal. Azithromycin treatment alters gene expression in inflammatory, lipid metabolism, and cell cycle pathways in well-differentiated human airway epithelia. PloS one. 2009 Jun; 4(6):e5806. doi: 10.1371/journal.pone.0005806. [PMID: 19503797]
  • Flavia Marinelli. Chapter 2. From microbial products to novel drugs that target a multitude of disease indications. Methods in enzymology. 2009; 458(?):29-58. doi: 10.1016/s0076-6879(09)04802-2. [PMID: 19374978]
  • Jamie Cameron, Trine Ranheim, Mari Ann Kulseth, Trond P Leren, Knut Erik Berge. Berberine decreases PCSK9 expression in HepG2 cells. Atherosclerosis. 2008 Dec; 201(2):266-73. doi: 10.1016/j.atherosclerosis.2008.02.004. [PMID: 18355829]
  • Shuhei Kawahara, Yasuaki Hata, Takeshi Kita, Ryoichi Arita, Muneki Miura, Shintaro Nakao, Yasutaka Mochizuki, Hiroshi Enaida, Tadahisa Kagimoto, Yoshinobu Goto, Ali Hafezi-Moghadam, Tatsuro Ishibashi. Potent inhibition of cicatricial contraction in proliferative vitreoretinal diseases by statins. Diabetes. 2008 Oct; 57(10):2784-93. doi: 10.2337/db08-0302. [PMID: 18599521]
  • Fatimata Seydou Sarr, Yves Claude Guillaume, Claire André. Magnesium cation effect on passive diffusion of statin molecules: molecular chromatography approach. Journal of pharmaceutical and biomedical analysis. 2008 Jul; 47(3):651-7. doi: 10.1016/j.jpba.2008.02.008. [PMID: 18378106]
  • Livia Puljak, Vinay Parameswara, Svjetlana Dolovcak, Shar L Waldrop, Daniel Emmett, Victoria Esser, J Gregory Fitz, Gordan Kilic. Evidence for AMPK-dependent regulation of exocytosis of lipoproteins in a model liver cell line. Experimental cell research. 2008 Jun; 314(10):2100-9. doi: 10.1016/j.yexcr.2008.03.002. [PMID: 18405894]
  • Fatimata Seydou Sarr, Claire André, Yves Claude Guillaume. Statins (HMG-coenzyme A reductase inhibitors)-biomimetic membrane binding mechanism investigated by molecular chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Jun; 868(1-2):20-7. doi: 10.1016/j.jchromb.2008.03.034. [PMID: 18479982]
  • Magdalena Winiarska, Jacek Bil, Ewa Wilczek, Grzegorz M Wilczynski, Malgorzata Lekka, Patrick J Engelberts, Wendy J M Mackus, Elzbieta Gorska, Lukasz Bojarski, Tomasz Stoklosa, Dominika Nowis, Zuzanna Kurzaj, Marcin Makowski, Eliza Glodkowska, Tadeusz Issat, Piotr Mrowka, Witold Lasek, Anna Dabrowska-Iwanicka, Grzegorz W Basak, Maria Wasik, Krzysztof Warzocha, Maciej Sinski, Zbigniew Gaciong, Marek Jakobisiak, Paul W H I Parren, Jakub Golab. Statins impair antitumor effects of rituximab by inducing conformational changes of CD20. PLoS medicine. 2008 Mar; 5(3):e64. doi: 10.1371/journal.pmed.0050064. [PMID: 18366248]
  • Roger S Holmes, Jeannie Chan, Laura A Cox, William J Murphy, John L VandeBerg. Opossum carboxylesterases: sequences, phylogeny and evidence for CES gene duplication events predating the marsupial-eutherian common ancestor. BMC evolutionary biology. 2008 Feb; 8(?):54. doi: 10.1186/1471-2148-8-54. [PMID: 18289373]
  • Leiv Ose. The real code of leonardo da vinci. Current cardiology reviews. 2008 Feb; 4(1):60-2. doi: 10.2174/157340308783565401. [PMID: 19924278]
  • Sharon A Glynn, Dermot O'Sullivan, Alex J Eustace, Martin Clynes, Norma O'Donovan. The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells. BMC cancer. 2008 Jan; 8(?):9. doi: 10.1186/1471-2407-8-9. [PMID: 18199328]
  • Navin K Kapur, Kiran Musunuru. Clinical efficacy and safety of statins in managing cardiovascular risk. Vascular health and risk management. 2008; 4(2):341-53. doi: 10.2147/vhrm.s1653. [PMID: 18561510]
  • Yaxi Chen, Xiong Z Ruan, Qiu Li, Ailong Huang, John F Moorhead, Stephen H Powis, Zac Varghese. Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cells. American journal of physiology. Renal physiology. 2007 Sep; 293(3):F680-7. doi: 10.1152/ajprenal.00209.2007. [PMID: 17634396]
  • Norimasa Tamehiro, Yukari Shigemoto-Mogami, Tomoshi Kakeya, Kei-Ichiro Okuhira, Kazuhiro Suzuki, Ryuichiro Sato, Taku Nagao, Tomoko Nishimaki-Mogami. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status. The Journal of biological chemistry. 2007 Jul; 282(29):21090-9. doi: 10.1074/jbc.m701228200. [PMID: 17526932]
  • Shingo Suzuki, Kazuyuki Kiyosue, Shunsuke Hazama, Akihiko Ogura, Megumi Kashihara, Tomoko Hara, Hisatsugu Koshimizu, Masami Kojima. Brain-derived neurotrophic factor regulates cholesterol metabolism for synapse development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Jun; 27(24):6417-27. doi: 10.1523/jneurosci.0690-07.2007. [PMID: 17567802]
  • Alexey A Nabatov, Georgios Pollakis, Thomas Linnemann, William A Paxton, Michel P de Baar. Statins disrupt CCR5 and RANTES expression levels in CD4(+) T lymphocytes in vitro and preferentially decrease infection of R5 versus X4 HIV-1. PloS one. 2007 May; 2(5):e470. doi: 10.1371/journal.pone.0000470. [PMID: 17520029]
  • Sota Omoigui. The Interleukin-6 inflammation pathway from cholesterol to aging--role of statins, bisphosphonates and plant polyphenols in aging and age-related diseases. Immunity & ageing : I & A. 2007 Mar; 4(?):1. doi: 10.1186/1742-4933-4-1. [PMID: 17374166]
  • Jelena Radjenovic, Mira Petrovic, Damiá Barceló. Analysis of pharmaceuticals in wastewater and removal using a membrane bioreactor. Analytical and bioanalytical chemistry. 2007 Feb; 387(4):1365-77. doi: 10.1007/s00216-006-0883-6. [PMID: 17115140]
  • Casper G Schalkwijk, Bastiaan van Dam, Coen D A Stehouwer, Victor W M van Hinsbergh. Mevastatin increases eNO synthase expression and inhibits lipid peroxidation in human endothelial cells. Clinical hemorheology and microcirculation. 2007; 37(1-2):179-84. doi: ". [PMID: 17641407]
  • Benita Sjögren, Mark W Hamblin, Per Svenningsson. Cholesterol depletion reduces serotonin binding and signaling via human 5-HT(7(a)) receptors. European journal of pharmacology. 2006 Dec; 552(1-3):1-10. doi: 10.1016/j.ejphar.2006.08.069. [PMID: 17064686]
  • Meritxell Gros, Mira Petrović, Damiá Barceló. Development of a multi-residue analytical methodology based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) for screening and trace level determination of pharmaceuticals in surface and wastewaters. Talanta. 2006 Nov; 70(4):678-90. doi: 10.1016/j.talanta.2006.05.024. [PMID: 18970827]
  • Jakub Kwintkiewicz, Nastaran Foyouzi, Piotr Piotrowski, Izabela Rzepczynska, Antoni J Duleba. Mevastatin inhibits proliferation of rat ovarian theca-interstitial cells by blocking the mitogen-activated protein kinase pathway. Fertility and sterility. 2006 Oct; 86(4 Suppl):1053-8. doi: 10.1016/j.fertnstert.2006.04.020. [PMID: 16963032]
  • Piotr C Piotrowski, Jakub Kwintkiewicz, Izabela J Rzepczynska, Yasemin Seval, Hakan Cakmak, Aydin Arici, Antoni J Duleba. Statins inhibit growth of human endometrial stromal cells independently of cholesterol availability. Biology of reproduction. 2006 Jul; 75(1):107-11. doi: 10.1095/biolreprod.106.051763. [PMID: 16571871]
  • Samer J Nuwayhid, Martha Vega, Paul D Walden, Marie E Monaco. Regulation of de novo phosphatidylinositol synthesis. Journal of lipid research. 2006 Jul; 47(7):1449-56. doi: 10.1194/jlr.m600077-jlr200. [PMID: 16651661]
  • Dmitry E Shvartsman, Orit Gutman, Aliza Tietz, Yoav I Henis. Cyclodextrins but not compactin inhibit the lateral diffusion of membrane proteins independent of cholesterol. Traffic (Copenhagen, Denmark). 2006 Jul; 7(7):917-26. doi: 10.1111/j.1600-0854.2006.00437.x. [PMID: 16787400]
  • Ilaria Zanotti, Francesco Potì, Elda Favari, Knut R Steffensen, Jan-Ake Gustafsson, Franco Bernini. Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages: evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP. The Journal of pharmacology and experimental therapeutics. 2006 Apr; 317(1):395-401. doi: 10.1124/jpet.105.093930. [PMID: 16415093]
  • Daniela Hampel, Armin Mosandl, Matthias Wüst. Biosynthesis of mono- and sesquiterpenes in strawberry fruits and foliage: 2H labeling studies. Journal of agricultural and food chemistry. 2006 Feb; 54(4):1473-8. doi: 10.1021/jf0523972. [PMID: 16478276]
  • M N Kelly-Skupek, H R Irving. Pharmacological evidence for activation of phospholipid and small GTP binding protein signalling cascades by Nod factors. Plant physiology and biochemistry : PPB. 2006 Feb; 44(2-3):132-42. doi: 10.1016/j.plaphy.2006.03.004. [PMID: 16647267]
  • Anne R Kinderlerer, Rivka Steinberg, Michael Johns, Sarah K Harten, Elaine A Lidington, Dorian O Haskard, Patrick H Maxwell, Justin C Mason. Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis. Arthritis research & therapy. 2006; 8(4):R130. doi: 10.1186/ar2019. [PMID: 16859540]
  • Maria J Crespo, José A Quidgley. Statins decrease serotonin-induced contractions in coronary arteries of swine in vitro. Pharmacology. 2006; 76(3):141-7. doi: 10.1159/000091045. [PMID: 16428899]
  • Heather P Harding, Yuhong Zhang, Sonya Khersonsky, Stefan Marciniak, Donalyn Scheuner, Randal J Kaufman, Norman Javitt, Young-Tae Chang, David Ron. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell metabolism. 2005 Dec; 2(6):361-71. doi: 10.1016/j.cmet.2005.11.005. [PMID: 16330322]
  • D Kaul, M I Baba. Genomic effect of vitamin 'C' and statins within human mononuclear cells involved in atherogenic process. European journal of clinical nutrition. 2005 Aug; 59(8):978-81. doi: 10.1038/sj.ejcn.1602203. [PMID: 15970944]
  • Sevim Gullu, Rifat Emral, Mehmet Bastemir, Arthur B Parkes, John H Lazarus. In vivo and in vitro effects of statins on lymphocytes in patients with Hashimoto's thyroiditis. European journal of endocrinology. 2005 Jul; 153(1):41-8. doi: 10.1530/eje.1.01941. [PMID: 15994744]
  • Meltem C Arikan, Steven D Shapiro, Thomas J Mariani. Induction of macrophage elastase (MMP-12) gene expression by statins. Journal of cellular physiology. 2005 Jul; 204(1):139-45. doi: 10.1002/jcp.20271. [PMID: 15605420]
  • Benedetta Bussolati, Maria Chiara Deregibus, Valentina Fonsato, Sophie Doublier, Tiziana Spatola, Simone Procida, Francesco Di Carlo, Giovanni Camussi. Statins prevent oxidized LDL-induced injury of glomerular podocytes by activating the phosphatidylinositol 3-kinase/AKT-signaling pathway. Journal of the American Society of Nephrology : JASN. 2005 Jul; 16(7):1936-47. doi: 10.1681/asn.2004080629. [PMID: 15843472]
  • J I Cohen. HMG CoA reductase inhibitors (statins) to treat Epstein-Barr virus-driven lymphoma. British journal of cancer. 2005 May; 92(9):1593-8. doi: 10.1038/sj.bjc.6602561. [PMID: 15856040]
  • Daniela Hampel, Armin Mosandl, Matthias Wüst. Induction of de novo volatile terpene biosynthesis via cytosolic and plastidial pathways by methyl jasmonate in foliage of Vitis vinifera L. Journal of agricultural and food chemistry. 2005 Apr; 53(7):2652-7. doi: 10.1021/jf040421q. [PMID: 15796607]
  • Bo Bang, Robert Gniadecki, Barbara Gajkowska. Disruption of lipid rafts causes apoptotic cell death in HaCaT keratinocytes. Experimental dermatology. 2005 Apr; 14(4):266-72. doi: 10.1111/j.0906-6705.2005.00283.x. [PMID: 15810884]
  • Michael S Brown, Joseph L Goldstein. Lowering plasma cholesterol by raising ldl receptors. 1981. Atherosclerosis. Supplements. 2004 Oct; 5(3):57-9. doi: 10.1016/j.atherosclerosissup.2004.08.024. [PMID: 15531276]
  • Hiroshi Mabuchi, Toshihiro Haba, Ryzo Tatami, Susumu Miyamoto, Yasuyuki Sakai, Takanobu Wakasugi, Akira Watanabe, Junji Koizumi, Ryoyu Takeda. Effects of an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase on serum lipoproteins and ubiquinone-10 levels in patients with familial hypercholesterolemia. 1981. Atherosclerosis. Supplements. 2004 Oct; 5(3):51-5. doi: 10.1016/j.atherosclerosissup.2004.08.023. [PMID: 15531275]
  • Judith Haendeler, Jörg Hoffmann, Andreas M Zeiher, Stefanie Dimmeler. Antioxidant effects of statins via S-nitrosylation and activation of thioredoxin in endothelial cells: a novel vasculoprotective function of statins. Circulation. 2004 Aug; 110(7):856-61. doi: 10.1161/01.cir.0000138743.09012.93. [PMID: 15289372]
  • Klaudia Budzyn, Philip D Marley, Christopher G Sobey. Chronic mevastatin modulates receptor-dependent vascular contraction in eNOS-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology. 2004 Aug; 287(2):R342-8. doi: 10.1152/ajpregu.00156.2004. [PMID: 15130878]
  • Doris L Fortin, Matthew D Troyer, Ken Nakamura, Shin-ichiro Kubo, Malcolm D Anthony, Robert H Edwards. Lipid rafts mediate the synaptic localization of alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Jul; 24(30):6715-23. doi: 10.1523/jneurosci.1594-04.2004. [PMID: 15282274]
  • Robert Gniadecki. Depletion of membrane cholesterol causes ligand-independent activation of Fas and apoptosis. Biochemical and biophysical research communications. 2004 Jul; 320(1):165-9. doi: 10.1016/j.bbrc.2004.05.145. [PMID: 15207716]
  • Anil K Nair, K M J Menon. Isolation and characterization of a novel trans-factor for luteinizing hormone receptor mRNA from ovary. The Journal of biological chemistry. 2004 Apr; 279(15):14937-44. doi: 10.1074/jbc.m309484200. [PMID: 14749336]
  • Hassan M A M Qazzaz, Zhimin Cao, Duane D Bolanowski, Barbara J Clark, Roland Valdes. De novo biosynthesis and radiolabeling of mammalian digitalis-like factors. Clinical chemistry. 2004 Mar; 50(3):612-20. doi: 10.1373/clinchem.2003.022715. [PMID: 14981028]
  • Shogo Suzuki, Tomoko Nishimaki-Mogami, Norimasa Tamehiro, Kazuhide Inoue, Reijiro Arakawa, Sumiko Abe-Dohmae, Arowu R Tanaka, Kazumitsu Ueda, Shinji Yokoyama. Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. Arteriosclerosis, thrombosis, and vascular biology. 2004 Mar; 24(3):519-25. doi: 10.1161/01.atv.0000117178.94087.ba. [PMID: 14726413]
  • M Föcking, M Besselmann, T Trapp. Statins potentiate caspase-3 activity in immortalized murine neurons. Neuroscience letters. 2004 Jan; 355(1-2):41-4. doi: 10.1016/j.neulet.2003.10.022. [PMID: 14729230]
  • Sultan Darvesh, Earl Martin, Ryan Walsh, Kenneth Rockwood. Differential effects of lipid-lowering agents on human cholinesterases. Clinical biochemistry. 2004 Jan; 37(1):42-9. doi: 10.1016/j.clinbiochem.2003.09.004. [PMID: 14675561]
  • Richard A Zager, Ali C M Johnson, Sherry Y Hanson. Proximal tubular cholesterol loading after mitochondrial, but not glycolytic, blockade. American journal of physiology. Renal physiology. 2003 Dec; 285(6):F1092-9. doi: 10.1152/ajprenal.00187.2003. [PMID: 12952856]
  • Kamal Krishna Biswas, Krishna Pada Sarker, Kazuhiro Abeyama, Ko-ichi Kawahara, Satoshi Iino, Yasuharu Otsubo, Kazuhiko Saigo, Hiroyuki Izumi, Teruto Hashiguchi, Munekazu Yamakuchi, Kazuyo Yamaji, Ryujin Endo, Kazuyuki Suzuki, Hitoshi Imaizumi, Ikuro Maruyama. Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis. Hepatology (Baltimore, Md.). 2003 Nov; 38(5):1167-77. doi: 10.1053/jhep.2003.50459. [PMID: 14578855]
  • Emilia Lecuona, Karen Ridge, Liuska Pesce, Daniel Batlle, Jacob I Sznajder. The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells. Molecular biology of the cell. 2003 Sep; 14(9):3888-97. doi: 10.1091/mbc.e02-12-0781. [PMID: 12972572]
  • Jie Dong, Satoshi Fujii, Daisuke Goto, Tomoo Furumoto, Takeaki Kaneko, Tarkikuz A Zaman, Yukihito Nakai, Tetsuya Mishima, Shogo Imagawa, Akira Kitabatake. Increased expression of plasminogen activator inhibitor-1 by mediators of the acute phase response: a potential progenitor of vasculopathy in hypertensives. Hypertension research : official journal of the Japanese Society of Hypertension. 2003 Sep; 26(9):723-9. doi: 10.1291/hypres.26.723. [PMID: 14620928]
  • Tushar R Patel, Siobhan A Corbett. Mevastatin suppresses lipopolysaccharide-induced Rac activation in the human monocyte cell line THP-1. Surgery. 2003 Aug; 134(2):306-11. doi: 10.1067/msy.2003.241. [PMID: 12947334]
  • Joannis E Vamvakopoulos, Colin Green. HMG-CoA reductase inhibition aborts functional differentiation and triggers apoptosis in cultured primary human monocytes: a potential mechanism of statin-mediated vasculoprotection. BMC cardiovascular disorders. 2003 Jul; 3(?):6. doi: 10.1186/1471-2261-3-6. [PMID: 12871602]
  • Sayaka Takemoto-Kimura, Hisashi Terai, Maki Takamoto, Shogo Ohmae, Shoko Kikumura, Eri Segi, Yoshiki Arakawa, Tomoyuki Furuyashiki, Shuh Narumiya, Haruhiko Bito. Molecular cloning and characterization of CLICK-III/CaMKIgamma, a novel membrane-anchored neuronal Ca2+/calmodulin-dependent protein kinase (CaMK). The Journal of biological chemistry. 2003 May; 278(20):18597-605. doi: 10.1074/jbc.m300578200. [PMID: 12637513]
  • Heike Hering, Chih-Chun Lin, Morgan Sheng. Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003 Apr; 23(8):3262-71. doi: 10.1523/jneurosci.23-08-03262.2003. [PMID: 12716933]
  • R Yoshioka, K Soga, K Wakabayashi, G Takeba, T Hoson. Hypergravity-induced changes in gene expression in Arabidopsis hypocotyls. Advances in space research : the official journal of the Committee on Space Research (COSPAR). 2003; 31(10):2187-93. doi: 10.1016/s0273-1177(03)00243-6. [PMID: 14686431]
  • Asha Naidu, Qiang Xu, Rosanne Catalano, Barbara Cordell. Secretion of apolipoprotein E by brain glia requires protein prenylation and is suppressed by statins. Brain research. 2002 Dec; 958(1):100-11. doi: 10.1016/s0006-8993(02)03480-7. [PMID: 12468034]
  • Hiroyuki Kasahara, Atsushi Hanada, Tomohisa Kuzuyama, Motoki Takagi, Yuji Kamiya, Shinjiro Yamaguchi. Contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthesis of gibberellins in Arabidopsis. The Journal of biological chemistry. 2002 Nov; 277(47):45188-94. doi: 10.1074/jbc.m208659200. [PMID: 12228237]
  • Nelson Arispe, Michael Doh. Plasma membrane cholesterol controls the cytotoxicity of Alzheimer's disease AbetaP (1-40) and (1-42) peptides. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2002 Oct; 16(12):1526-36. doi: 10.1096/fj.02-0829com. [PMID: 12374775]
  • Judy Raucy, Lyndon Warfe, Mei-Fei Yueh, Scott W Allen. A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system. The Journal of pharmacology and experimental therapeutics. 2002 Oct; 303(1):412-23. doi: 10.1124/jpet.102.038653. [PMID: 12235278]
  • Cang-Bao Xu, Emelie Stenman, Lars Edvinsson. Reduction of bFGF-induced smooth muscle cell proliferation and endothelin receptor mRNA expression by mevastatin and atorvastatin. Biochemical pharmacology. 2002 Aug; 64(3):497-505. doi: 10.1016/s0006-2952(02)01189-9. [PMID: 12147302]
  • M Manzoni, M Rollini. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Applied microbiology and biotechnology. 2002 Apr; 58(5):555-64. doi: 10.1007/s00253-002-0932-9. [PMID: 11956737]
  • Elena Gubina, Trina Chen, Lei Zhang, Elaine F Lizzio, Steven Kozlowski. CD43 polarization in unprimed T cells can be dissociated from raft coalescence by inhibition of HMG CoA reductase. Blood. 2002 Apr; 99(7):2518-25. doi: 10.1182/blood.v99.7.2518. [PMID: 11895788]
  • T L Miller, M J Wolin. Inhibition of growth of methane-producing bacteria of the ruminant forestomach by hydroxymethylglutaryl-SCoA reductase inhibitors. Journal of dairy science. 2001 Jun; 84(6):1445-8. doi: 10.3168/jds.s0022-0302(01)70177-4. [PMID: 11417704]
  • R A Zager, A Johnson, K Anderson, S Wright. Cholesterol ester accumulation: an immediate consequence of acute in vivo ischemic renal injury. Kidney international. 2001 May; 59(5):1750-61. doi: 10.1046/j.1523-1755.2001.0590051750.x. [PMID: 11318945]
  • E J Park, D Lee, Y G Shin, D D Lantvit, R B van Breemen, A D Kinghorn, J M Pezzuto. Analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors using liquid chromatography-electrospray mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications. 2001 Apr; 754(2):327-32. doi: 10.1016/s0378-4347(00)00620-4. [PMID: 11339276]
  • P Doroshenko, V Sabanov, N Doroshenko. Cell cycle-related changes in regulatory volume decrease and volume-sensitive chloride conductance in mouse fibroblasts. Journal of cellular physiology. 2001 Apr; 187(1):65-72. doi: 10.1002/1097-4652(200104)187:1<65::aid-jcp1052>3.0.co;2-a. [PMID: 11241350]
  • S Amin-Hanjani, N E Stagliano, M Yamada, P L Huang, J K Liao, M A Moskowitz. Mevastatin, an HMG-CoA reductase inhibitor, reduces stroke damage and upregulates endothelial nitric oxide synthase in mice. Stroke. 2001 Apr; 32(4):980-6. doi: 10.1161/01.str.32.4.980. [PMID: 11283400]