2-Phenylacetamide (BioDeep_00000003076)
Secondary id: BioDeep_00000405674
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C8H9NO (135.0684)
中文名称: 2-苯基乙酰胺
谱图信息:
最多检出来源 Homo sapiens(otcml) 14.34%
分子结构信息
SMILES: C1=CC=C(C=C1)CC(=O)N
InChI: InChI=1S/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)
描述信息
2-Phenylacetamide is an intermediate in phenylalanine metabolism and styrene degradation(KEGG ID C02505). It is the third to last step in the synthesis of phenylacetylglutamine and is converted from phenylalanine via the enzyme phenylalanine 2-monooxygenase [EC:1.13.12.9]. It is then converted to phenylacetate via the enzyme amidase [EC:3.5.1.4]. [HMDB]
2-Phenylacetamide is an intermediate in phenylalanine metabolism and styrene degradation(KEGG ID C02505). It is the third to last step in the synthesis of phenylacetylglutamine and is converted from phenylalanine via the enzyme phenylalanine 2-monooxygenase [EC:1.13.12.9]. It is then converted to phenylacetate via the enzyme amidase [EC:3.5.1.4].
2-Phenylacetamide is an endogenous metabolite.
同义名列表
20 个代谢物同义名
(alpha-)2-Phenylacetamide; Phenylacetic acid amide; Phenyl-beta-acetylamine; beta-Phenyl-acetylamine; alpha-Toluimidic acid; alpha-Phenylacetamide; Phenyl-b-acetylamine; Phenyl-β-acetylamine; Phenylacetate amide; 2-Phenyl-acetamide; Α-phenylacetamide; 2-PHENYLACETAMIDE; a-Phenylacetamide; Benzeneacetamide; Phenylacetamide; alpha-Toluamide; Α-toluamide; a-Toluamide; 2-Phenylacetamide; 2-Phenylacetamide
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:16562
- KEGG: C02505
- PubChem: 7680
- HMDB: HMDB0010715
- Metlin: METLIN3260
- ChEMBL: CHEMBL347645
- Wikipedia: Acetanilide
- MetaCyc: CPD-238
- foodb: FDB027865
- chemspider: 7397
- CAS: 103-81-1
- PMhub: MS000007975
- PubChem: 5517
- 3DMET: B01582
- NIKKAJI: J55.331J
- RefMet: 2-Phenylacetamide
- RefMet: Phenylacetamide
- medchemexpress: HY-W018197
- KNApSAcK: 16562
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Phenylalanine Metabolism:
Ammonia + Cytochrome c-552 + Phenylpyruvic acid ⟶ Cytochrome c-552 + D-phenylalanine + Water
PharmGKB(0)
8 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
- 183589 - Pseudo-nitzschia multistriata: 10.3390/MD18060313
- 2016 - Streptoalloteichus: 10.7164/ANTIBIOTICS.37.1260
- 97398 - Streptomyces abikoensis: 10.1248/CPB.32.354
- 132473 - Streptomyces alboniger: 10.1271/BBB1961.37.679
- 68185 - Streptomyces chrestomyceticus:
- 278976 - Tedania ignis:
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mengnan Zeng, Meng Li, Miao Li, Beibei Zhang, Benke Li, Li Zhang, Weisheng Feng, Xiaoke Zheng. 2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo.
Molecules (Basel, Switzerland).
2018 Sep; 23(9):. doi:
10.3390/molecules23092293. [PMID: 30205508] - Luc H Boudreau, Jacques Maillet, Luc M LeBlanc, Jacques Jean-François, Mohamed Touaibia, Nicolas Flamand, Marc E Surette. Caffeic acid phenethyl ester and its amide analogue are potent inhibitors of leukotriene biosynthesis in human polymorphonuclear leukocytes.
PloS one.
2012; 7(2):e31833. doi:
10.1371/journal.pone.0031833. [PMID: 22347509] - Vikas Sharma, Jente Boonen, Nagendra S Chauhan, Mayank Thakur, Bart De Spiegeleer, V K Dixit. Spilanthes acmella ethanolic flower extract: LC-MS alkylamide profiling and its effects on sexual behavior in male rats.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Oct; 18(13):1161-9. doi:
10.1016/j.phymed.2011.06.001. [PMID: 21757328] - G Kanagasabapathy, S N A Malek, U R Kuppusamy, S Vikineswary. Chemical composition and antioxidant properties of extracts of fresh fruiting bodies of Pleurotus sajor-caju (Fr.) Singer.
Journal of agricultural and food chemistry.
2011 Mar; 59(6):2618-26. doi:
10.1021/jf104133g. [PMID: 21348494] - J Boonen, B Baert, C Burvenich, P Blondeel, S De Saeger, B De Spiegeleer. LC-MS profiling of N-alkylamides in Spilanthes acmella extract and the transmucosal behaviour of its main bio-active spilanthol.
Journal of pharmaceutical and biomedical analysis.
2010 Nov; 53(3):243-9. doi:
10.1016/j.jpba.2010.02.010. [PMID: 20227845] - Akihiro Furukawa, Tsuyoshi Arita, Susumu Satoh, Kenji Wakabayashi, Shinko Hayashi, Yumi Matsui, Kazushi Araki, Masanori Kuroha, Jun Ohsumi. Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives.
Bioorganic & medicinal chemistry letters.
2010 Apr; 20(7):2095-8. doi:
10.1016/j.bmcl.2010.02.073. [PMID: 20219371] - Rory P Remmel, Brenda C Crews, Kevin R Kozak, Amit S Kalgutkar, Lawrence J Marnett, Amit S Algutkar. Studies on the metabolism of the novel, selective cyclooxygenase-2 inhibitor indomethacin phenethylamide in rat, mouse, and human liver microsomes: identification of active metabolites.
Drug metabolism and disposition: the biological fate of chemicals.
2004 Jan; 32(1):113-22. doi:
10.1124/dmd.32.1.113. [PMID: 14709628] - Kazumi Osada, Kunio Yamazaki, Maryanne Curran, Judith Bard, Benjamin P C Smith, Gary K Beauchamp. The scent of age.
Proceedings. Biological sciences.
2003 May; 270(1518):929-33. doi:
10.1098/rspb.2002.2308. [PMID: 12803907]
