Brucin (BioDeep_00000298509)

Main id: BioDeep_00000003105

 


代谢物信息卡片


InChI=1\C23H26N2O4\c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18\h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H

化学式: C23H26N2O4 (394.18924760000004)
中文名称: 聚酰胺固化剂(650), 马钱子碱, 聚酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C=C2C(=C1)C34CCN5C3CC6C7C4N2C(=O)CC7OCC=C6C5)OC
InChI: InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3/t13-,18-,19-,21-,22-,23+/m0/s1

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D007155 - Immunologic Factors

同义名列表

20 个代谢物同义名

InChI=1\C23H26N2O4\c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18\h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H; (8ξ,12ξ)-2,3-dimethoxystrychnidin-10-one; 4845-99-2 (MONOSULFATE); nchembio.2007.55-comp3; 357-57-3 (FREE BASE); 399027_ALDRICH; MEGxp0_001865; MLS000515808; SMR000112281; ACon1_001990; AIDS-002665; AIDS002665; BB_NC-0718; Polyamide; l-Brucine; UN 1570; Brucina; brucine; Brucin; C09084



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yong Yang, Peng Li, Xiaojia Li, Ying Zhu, Xiutian Guo. Brucine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464. Chemical biology & drug design. 2024 Jan; 103(1):e14407. doi: 10.1111/cbdd.14407. [PMID: 38040413]
  • Min Wu, Yi Hu, Mengran Xu, Lijuan Fu, Chengpan Li, Jingjing Wu, Xin Sun, Wenshen Wang, Shaozhen Wang, Ting Wang, Weiping Ding, Ping Li. Transdermal delivery of brucine-encapsulated liposomes significantly enhances anti-tumor outcomes in treating triple-negative breast cancer. Biomaterials advances. 2023 Jul; 153(?):213566. doi: 10.1016/j.bioadv.2023.213566. [PMID: 37536027]
  • Yan Gao, Lin Guo, Ying Han, Jingpu Zhang, Zhong Dai, Shuangcheng Ma. A Combination of In Silico ADMET Prediction, In Vivo Toxicity Evaluation, and Potential Mechanism Exploration of Brucine and Brucine N-oxide-A Comparative Study. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031341. [PMID: 36771007]
  • Shan Lu, Xuan-Zhong Wang, Chuan He, Lei Wang, Shi-Peng Liang, Chong-Cheng Wang, Chen Li, Tian-Fei Luo, Chun-Sheng Feng, Zhen-Chuan Wang, Guang-Fan Chi, Peng-Fei Ge. ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron. Acta pharmacologica Sinica. 2021 Oct; 42(10):1690-1702. doi: 10.1038/s41401-021-00700-w. [PMID: 34112960]
  • Bin Liu, Yuqing Zhang, Qingke Wu, Li Wang, Bo Hu. Alleviation of isoprenaline hydrochloride induced myocardial ischemia injury by brucine through the inhibition of Na+/K+-ATPase. Experimental gerontology. 2021 07; 149(?):111332. doi: 10.1016/j.exger.2021.111332. [PMID: 33781843]
  • Lu Gao, Yanke Lin, Shuai Wang, Luomin Lin, Danyi Lu, Yue Zhao, Huijie Xing, Baojian Wu. Chronotoxicity of Semen Strychni is associated with circadian metabolism and transport in mice. The Journal of pharmacy and pharmacology. 2021 Mar; 73(3):398-409. doi: 10.1093/jpp/rgaa007. [PMID: 33793874]
  • Heba S Elsewedy, Bandar E Al Dhubiab, Mahmoud A Mahdy, Hanan M Elnahas. Development, optimization, and evaluation of PEGylated brucine-loaded PLGA nanoparticles. Drug delivery. 2020 Dec; 27(1):1134-1146. doi: 10.1080/10717544.2020.1797237. [PMID: 32729331]
  • Min Zhang, Chao Wang, Zheng-Lin Ou, Jing Wen, Hua-Lin Cai, Ping-Fei Fang. Effects of licorice extracts on the pharmacokinetics of brucine in rats and its possible mechanism. Pakistan journal of pharmaceutical sciences. 2020 Sep; 33(5):1995-2002. doi: . [PMID: 33824106]
  • Dan Lü, Qieying Jiang, Jing Zhang, Ronggui Zeng, Zhenggen Liao, Xinli Liang. Effect of Baizhu (Rhizoma Atractylodis Macrocephalae) extract on intestinal absorption of brucine and strychnine in vitro and in situ. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2020 08; 40(4):562-570. doi: 10.19852/j.cnki.jtcm.2020.04.005. [PMID: 32744023]
  • Nestor Ishimwe, Pengfei Wei, Meimei Wang, Hao Zhang, Liansheng Wang, Manman Jing, Longping Wen, Yunjiao Zhang. Autophagy Impairment through Lysosome Dysfunction by Brucine Induces Immunogenic Cell Death (ICD). The American journal of Chinese medicine. 2020; 48(8):1915-1940. doi: 10.1142/s0192415x20500962. [PMID: 33308096]
  • Min Zhang, Chao Wang, Hua-Lin Cai, Jing Wen, Ping-Fei Fang. Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation. Current medical science. 2019 Dec; 39(6):890-898. doi: 10.1007/s11596-019-2126-z. [PMID: 31845219]
  • Ziyue Zhou, Yanke Lin, Lu Gao, Zemin Yang, Shuai Wang, Baojian Wu. Cyp3a11 metabolism-based chronotoxicity of brucine in mice. Toxicology letters. 2019 Oct; 313(?):188-195. doi: 10.1016/j.toxlet.2019.07.007. [PMID: 31284022]
  • Hua Ren, Jianping Zhao, Dongsheng Fan, Ze Wang, Tingjie Zhao, Yuejin Li, Yirui Zhao, David Adelson, Huiqin Hao. Alkaloids from nux vomica suppresses colon cancer cell growth through Wnt/β-catenin signaling pathway. Phytotherapy research : PTR. 2019 May; 33(5):1570-1578. doi: 10.1002/ptr.6347. [PMID: 30907037]
  • Guang Yu, Linnan Qian, Juanjuan Yu, Min Tang, Changming Wang, Yuan Zhou, Xiao Geng, Chan Zhu, Yan Yang, Yang Pan, Xu Shen, Zongxiang Tang. Brucine alleviates neuropathic pain in mice via reducing the current of the sodium channel. Journal of ethnopharmacology. 2019 Apr; 233(?):56-63. doi: 10.1016/j.jep.2018.12.045. [PMID: 30599222]
  • Meng-Ran Xu, Peng-Fei Wei, Ming-Zhu Suo, Yi Hu, Weiping Ding, Li Su, Yao-Dong Zhu, Wan-Ji Song, Guan-Hao Tang, Mei Zhang, Ping Li. Brucine Suppresses Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cell Line MDA-MB-231. BioMed research international. 2019; 2019(?):6543230. doi: 10.1155/2019/6543230. [PMID: 30723742]
  • Uma Saminathan, Pachaiappan Pugalendhi, Suganthi Subramaniyan, Rajendran Jayaganesh. Biochemical studies evaluating the chemopreventive potential of brucine in chemically induced mammary carcinogenesis of rats. Toxicology mechanisms and methods. 2019 Jan; 29(1):8-17. doi: 10.1080/15376516.2018.1502387. [PMID: 30027798]
  • Chunhua Yuan, Zhengyi Luo, Ying Zhou, Sheng Lei, Changxi Xu, Chao Peng, Shuji Li, Xiaowen Li, Xinhong Zhu, Tianming Gao. Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure-activity relationships of strychnine and its analogs. Toxicology and applied pharmacology. 2018 12; 360(?):109-119. doi: 10.1016/j.taap.2018.09.042. [PMID: 30282042]
  • Jian-Bo Ma, Hai-Wen Qiu, Qiu-Hong Rui, Yu-Feng Liao, Yan-Min Chen, Jin Xu, Yun Zhang, Yan Zhu, Yong-Gang Zhao. Enhanced cleanup efficiency hydroxy functionalized-magnetic graphene oxide and its comparison with magnetic carboxyl-graphene for PRiME pass-through cleanup of strychnine and brucine in human plasma samples. Analytica chimica acta. 2018 Aug; 1020(?):41-50. doi: 10.1016/j.aca.2018.03.008. [PMID: 29655427]
  • Tiankun Ren, Menglin Li, Hao Zheng, Wenwei Liu, Jinlan Zhang. Microdialysis combined with RRLC-MS/MS for the pharmacokinetics of two major alkaloids of Bi qi capsule and the potential roles of P-gp and BCRP on their penetration. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Aug; 1092(?):72-81. doi: 10.1016/j.jchromb.2018.05.048. [PMID: 29883892]
  • Xianpeng Shi, Man Zhu, Yuan Kang, Tianfeng Yang, Xia Chen, Yanmin Zhang. Wnt/β-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jul; 46(?):85-92. doi: 10.1016/j.phymed.2018.04.019. [PMID: 30097126]
  • Shujuan Li, Yanjie Chu, Ruowen Zhang, Linjia Sun, Xiaohui Chen. Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components. Nutrients. 2018 Apr; 10(4):. doi: 10.3390/nu10040514. [PMID: 29677121]
  • Hao Zheng, Zhe Wang, Wenwei Liu, Hongtao Jin, Jinlan Zhang. Toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats by RRLC-MS/MS. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4117. [PMID: 29027676]
  • Min Zhang, Yang Deng, Chao Wang, Hua-Lin Cai, Jing Wen, Ping-Fei Fang, Bi-Kui Zhang, Huan-De Li, Miao Yan. An LC-MS/MS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma: Application to a pharmacokinetics study. Drug testing and analysis. 2018 Feb; 10(2):262-271. doi: 10.1002/dta.2210. [PMID: 28447397]
  • Rutesh Savalia, Sanghamitra Chatterjee. Sensitive detection of brucine an anti-metastatic drug for hepatocellular carcinoma at carbon nanotubes - nafion composite based biosensor. Biosensors & bioelectronics. 2017 Dec; 98(?):371-377. doi: 10.1016/j.bios.2017.07.011. [PMID: 28709086]
  • P N Prasad Maddisetty, V A Doss, Mohanasundaram S, Srinivasarao V, Mohanbabu T. HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves. Pakistan journal of pharmaceutical sciences. 2017 Nov; 30(6(Supplementary)):2369-2373. doi: . [PMID: 29188771]
  • Ping Wu, Qin Liang, Pei Feng, Chunyan Li, Chunguang Yang, Hongsuo Liang, Huaibo Tang, Cijun Shuai. A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities. International journal of molecular sciences. 2017 Apr; 18(4):. doi: 10.3390/ijms18040757. [PMID: 28368343]
  • Nongshan Zhang, Yiyun Wu, Runlin Xing, Bo Xu, Dai Guoliang, Peimin Wang. Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine. BioMed research international. 2017; 2017(?):3273816. doi: 10.1155/2017/3273816. [PMID: 29349071]
  • Wei Gu, Dongyue Wang, Zihao Pan, Xiao Liu, Baochang Cai, Jun Chen. Ultra-performance liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of brucine, strychnine and brucine N-oxide in rat plasma: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2016 Jul; 30(7):1097-1103. doi: 10.1002/bmc.3656. [PMID: 26578094]
  • Jun Guo, Hua Meng, Huang Huang Li, Qiao Feng Wang. Determination of strychnine, brucine, strychnine N-oxide, and brucine N-oxide in plasma samples after the oral administration of processed semen strychni extract by high-performance liquid chromatography with ultrasound-assisted mixed cloud point extraction. Journal of separation science. 2016 Jul; 39(13):2553-61. doi: 10.1002/jssc.201501379. [PMID: 27125604]
  • Aihua Lin, Xiaochun Su, Dan She, Kuncheng Qiu, Qianmei He, Yiming Liu. LC-MS/MS determination and comparative pharmacokinetics of strychnine, brucine and their metabolites in rat plasma after intragastric administration of each monomer and the total alkaloids from Semen Strychni. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1008(?):65-73. doi: 10.1016/j.jchromb.2015.11.012. [PMID: 26625339]
  • Ruo-xuan Liu, Li-ming Li, Fei Wu, A-rong Li, Xia-wen Liu, Jie-wen Guo. [Pharmacokinetic Study on Brucine in Different Administration Methods of Liposome in Rats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Oct; 38(10):2125-8. doi: NULL. [PMID: 27254928]
  • Bo Li, Mei Sun, Zheng-ming Yang, Yi-jun Chen, Pan-pan Liu, Yuan Liu. [Contrasted study on pharmacokinetics of Tibetan medicine Renqing Mangjue compatible with Zuota]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2015 Jul; 40(14):2887-92. doi: NULL. [PMID: 26666045]
  • Zhipeng Chen, Liujie Zhang, Yang Song, Jiayu He, Li Wu, Can Zhao, Yanyu Xiao, Wei Li, Baochang Cai, Haibo Cheng, Weidong Li. Hierarchical targeted hepatocyte mitochondrial multifunctional chitosan nanoparticles for anticancer drug delivery. Biomaterials. 2015 Jun; 52(?):240-50. doi: 10.1016/j.biomaterials.2015.02.001. [PMID: 25818430]
  • Jun Chen, Chao-qin He, Ai-hua Lin, Wei Gu, Zhi-peng Chen, Wei Li, Bao-chang Cai. Thermosensitive liposomes with higher phase transition temperature for targeted drug delivery to tumor. International journal of pharmaceutics. 2014 Nov; 475(1-2):408-15. doi: 10.1016/j.ijpharm.2014.09.009. [PMID: 25218394]
  • Zhipeng Chen, Dan Liu, Jian Wang, Li Wu, Weidong Li, Jun Chen, Bao-Chang Cai, Haibo Cheng. Development of nanoparticles-in-microparticles system for improved local retention after intra-articular injection. Drug delivery. 2014 Aug; 21(5):342-50. doi: 10.3109/10717544.2013.848495. [PMID: 24215110]
  • Jian-Nan Sun, Juan Chen, Yan-Ping Shi. Ionic liquid-based electromembrane extraction and its comparison with traditional organic solvent based electromembrane extraction for the determination of strychnine and brucine in human urine. Journal of chromatography. A. 2014 Jul; 1352(?):1-7. doi: 10.1016/j.chroma.2014.05.037. [PMID: 24925450]
  • Liqiang Gu, Xiaofan Wang, Zhenzhen Liu, Ping Ju, Lunhui Zhang, Yuanyuan Zhang, Bingjie Ma, Kaishun Bi, Xiaohui Chen. A study of Semen Strychni-induced renal injury and herb-herb interaction of Radix Glycyrrhizae extract and/or Rhizoma Ligustici extract on the comparative toxicokinetics of strychnine and brucine in rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2014 Jun; 68(?):226-33. doi: 10.1016/j.fct.2014.03.028. [PMID: 24704041]
  • Jun Chen, Yange Qu, Dongyue Wang, Pei Peng, Hao Cai, Ying Gao, Zhipeng Chen, Baochang Cai. Pharmacological evaluation of total alkaloids from nux vomica: effect of reducing strychnine contents. Molecules (Basel, Switzerland). 2014 Apr; 19(4):4395-408. doi: 10.3390/molecules19044395. [PMID: 24727413]
  • Huaibo Tang, Miao Yan, Huande Li, Tianrong Xun, Yang Deng, Yeye Zhao, Long Deng. Dynamic detection of non-protein-bound strychnine and brucine in rabbit muscle and synovial fluid after topical application of total Strychnos alkaloid patches. Drug testing and analysis. 2014 Apr; 6(4):357-62. doi: 10.1002/dta.1493. [PMID: 23776063]
  • Xiumin Yang, Shuaihua Zhang, Juntao Wang, Chun Wang, Zhi Wang. On-line two-step stacking in capillary zone electrophoresis for the preconcentration of strychnine and brucine. Analytica chimica acta. 2014 Mar; 814(?):63-8. doi: 10.1016/j.aca.2014.01.027. [PMID: 24528845]
  • Jun Chen, Chao-Qin He, Ai-Hua Lin, Fei Xu, Fang Wang, Bo Zhao, Xiao Liu, Zhi-Peng Chen, Bao-chang Cai. Brucine-loaded liposomes composed of HSPC and DPPC at different ratios: in vitro and in vivo evaluation. Drug development and industrial pharmacy. 2014 Feb; 40(2):244-51. doi: 10.3109/03639045.2012.756009. [PMID: 23600656]
  • Wang Ruijun, Meng Wenbin, Wang Yumin, Zhang Ruijian, Huang Puweizhong, Li Yulin. Inhibition of Glioblastoma Cell Growth In Vitro and In Vivo by Brucine, a Component of Chinese Medicine. Oncology research. 2014; 22(5-6):275-81. doi: 10.3727/096504015x14344177566282. [PMID: 26629939]
  • Ji-Xin Tian, Min Wang, Lei Xu, Yuan Tian, Rui Song, Feng-Guo Xu, Zun-Jian Zhang. Metabolism of brucine: the important metabolic pathways of dihydroindole-type alkaloid for excretion in rats. Bioanalysis. 2014 Jan; 6(2):137-49. doi: 10.4155/bio.13.290. [PMID: 24423592]
  • Sarita Saraswati, Abdulqader A Alhaider, S S Agrawal. Anticarcinogenic effect of brucine in diethylnitrosamine initiated and phenobarbital-promoted hepatocarcinogenesis in rats. Chemico-biological interactions. 2013 Nov; 206(2):214-21. doi: 10.1016/j.cbi.2013.09.012. [PMID: 24060683]
  • Xin-Yue Song, Yan-Ping Shi, Juan Chen. Carbon nanotubes reinforced hollow fiber solid phase microextraction for the determination of strychnine and brucine in urine. Talanta. 2013 Nov; 116(?):188-94. doi: 10.1016/j.talanta.2013.05.025. [PMID: 24148391]
  • Xin Li, Kai Wang, Wei Wei, Yong-yu Liu, Lu Gong. In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates. Chemico-biological interactions. 2013 Aug; 204(3):140-3. doi: 10.1016/j.cbi.2013.05.007. [PMID: 23707193]
  • Jun Li, Jun Chen, Bao-Chang Cai, Tao Yang. Preparation, characterization and tissue distribution of brucine stealth liposomes with different lipid composition. Pharmaceutical development and technology. 2013 Jul; 18(4):772-8. doi: 10.3109/10837450.2011.598165. [PMID: 21780866]
  • Jun Chen, Wei Hu, Ye-Qing Qu, Jie Dong, Wei Gu, Ying Gao, Yun Fang, Fang Fang, Zhi-Peng Chen, Bao-Chang Cai. Evaluation of the pharmacodynamics and pharmacokinetics of brucine following transdermal administration. Fitoterapia. 2013 Apr; 86(?):193-201. doi: 10.1016/j.fitote.2013.03.007. [PMID: 23500380]
  • Dong-Yue Wang, Jun Chen, Bao-Chang Cai. [Optimization and application of method to determine plasma concentration of brucine]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2013 Apr; 38(7):1075-8. doi: NULL. [PMID: 23847961]
  • Zhipeng Chen, Juan Chen, Li Wu, Weidong Li, Jun Chen, Haibo Cheng, Jinhuo Pan, Baochang Cai. Hyaluronic acid-coated bovine serum albumin nanoparticles loaded with brucine as selective nanovectors for intra-articular injection. International journal of nanomedicine. 2013; 8(?):3843-53. doi: 10.2147/ijn.s50721. [PMID: 24124369]
  • Yanhui Fu, Yu Zhang, Hongping He, Li Hou, Yingtong Di, Shunlin Li, Xiaodong Luo, Xiaojiang Hao. Strynuxlines A and B, alkaloids with an unprecedented carbon skeleton from Strychnos nux-vomica. Journal of natural products. 2012 Nov; 75(11):1987-90. doi: 10.1021/np300339r. [PMID: 23088673]
  • Zhuhong Yu, Zhongping Wu, Feijun Gong, Rong Wong, Chen Liang, Yurong Zhang, Yunqiu Yu. Simultaneous determination of six toxic alkaloids in human plasma and urine using capillary zone electrophoresis coupled to time-of-flight mass spectrometry. Journal of separation science. 2012 Oct; 35(20):2773-80. doi: 10.1002/jssc.201200263. [PMID: 22997096]
  • Lan-fen Zhan, Ming-dong Liu, You-yi Yan, Yi Ye, Wei Wang, Zhi-hui Wang, Jun-hong Zhao, Lin-chuan Liao. [LC-MS/MS analysis of determination of strychnine and brucine in formaldehyde fixed tissue]. Fa yi xue za zhi. 2012 Oct; 28(5):347-50. doi: . [PMID: 23213784]
  • Zhi-peng Chen, Wen Liu, Dan Liu, Yan-yu Xiao, Hong-xuan Chen, Jun Chen, Weidong Li, Hao Cai, Wei Li, Bao-chang Cai, Jinhuo Pan. Development of brucine-loaded microsphere/thermally responsive hydrogel combination system for intra-articular administration. Journal of controlled release : official journal of the Controlled Release Society. 2012 Sep; 162(3):628-35. doi: 10.1016/j.jconrel.2012.07.037. [PMID: 22967750]
  • Ping Li, Mei Zhang, Wen-Jing Ma, Xin Sun, Fu-Peng Jin. Effects of brucine on vascular endothelial growth factor expression and microvessel density in a nude mouse model of bone metastasis due to breast cancer. Chinese journal of integrative medicine. 2012 Aug; 18(8):605-9. doi: 10.1007/s11655-012-1184-x. [PMID: 22855035]
  • Jun Chen, Lei Li, Yan Qi, Zhi-Peng Chen, Bao-Chang Cai. [Preparation and pharmacokinetics of brucine hydrogel patch]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2012 Aug; 35(8):1295-8. doi: NULL. [PMID: 23320365]
  • Hao Cai, Dandan Wang, Xiao Liu, Jun Chen, Baochang Cai. [Comparison on in vivo pharmacokinetics of brucine, total alkaloids of Strychni Semen and Strychni Semen pulveratum in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jul; 37(14):2160-3. doi: 10.4268/cjcmm20121428. [PMID: 23126206]
  • Hong-Mei Zhang, Zheng-Hao Fei, Bo-Ping Tang, Jian Chen, Wei-Hua Tao, Yan-Qing Wang. The interaction of blood proteins with brucine. Molecular biology reports. 2012 Apr; 39(4):4937-47. doi: 10.1007/s11033-011-1289-x. [PMID: 22160569]
  • Jingya Li, Fengru Miao, Li Lin, Dan Zhu, Chengren Lin, Jianxun Liu. [Determination of brucine and strychnine in rat after cutaneous administration of semen strychni niosome gel by LC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(6):853-7. doi: . [PMID: 22715737]
  • Jun Chen, Xuan Wang, Yan-Ge Qu, Zhi-Peng Chen, Hao Cai, Xiao Liu, Fei Xu, Tu-Lin Lu, Bao-Chang Cai. Analgesic and anti-inflammatory activity and pharmacokinetics of alkaloids from seeds of Strychnos nux-vomica after transdermal administration: effect of changes in alkaloid composition. Journal of ethnopharmacology. 2012 Jan; 139(1):181-8. doi: 10.1016/j.jep.2011.10.038. [PMID: 22094056]
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