Brucine (BioDeep_00000003105)

 

Secondary id: BioDeep_00000298509

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(8ξ,12ξ)-2,3-dimethoxystrychnidin-10-one

化学式: C23H26N2O4 (394.1892)
中文名称: 马钱子碱, 布鲁辛
谱图信息: 最多检出来源 Viridiplantae(plant) 39.75%

Reviewed

Last reviewed on 2024-08-14.

Cite this Page

Brucine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/brucine (retrieved 2024-12-23) (BioDeep RN: BioDeep_00000003105). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: COc(c(OC)7)cc(c(c7)1)N(C(=O)5)[C@@]([H])([C@]([H])42)[C@](C6)1[C@@]([H])(N3C6)C[C@@]([H])(C(=CCO[C@@]([H])(C5)4)C3)2
InChI: InChI=1S/C23H26N2O4/c1-27-16-8-14-15(9-17(16)28-2)25-20(26)10-18-21-13-7-19-23(14,22(21)25)4-5-24(19)11-12(13)3-6-29-18/h3,8-9,13,18-19,21-22H,4-7,10-11H2,1-2H3

描述信息

D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D007155 - Immunologic Factors
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2329
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.545
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.540
ORIGINAL_ACQUISITION_NO 5860; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; ORIGINAL_PRECURSOR_SCAN_NO 5859
CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5850; ORIGINAL_PRECURSOR_SCAN_NO 5847
CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5870; ORIGINAL_PRECURSOR_SCAN_NO 5868
CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5860; ORIGINAL_PRECURSOR_SCAN_NO 5859
CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5841; ORIGINAL_PRECURSOR_SCAN_NO 5839
CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5876; ORIGINAL_PRECURSOR_SCAN_NO 5873
CONFIDENCE standard compound; INTERNAL_ID 971; DATASET 20200303_ENTACT_RP_MIX502; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5855; ORIGINAL_PRECURSOR_SCAN_NO 5853
[Raw Data] CBA35_Brucine_pos_40eV_1-3_01_1629.txt
[Raw Data] CBA35_Brucine_pos_10eV_1-3_01_1618.txt
[Raw Data] CBA35_Brucine_pos_30eV_1-3_01_1628.txt
[Raw Data] CBA35_Brucine_pos_20eV_1-3_01_1627.txt
[Raw Data] CBA35_Brucine_pos_50eV_1-3_01_1630.txt

同义名列表

7 个代谢物同义名

(8ξ,12ξ)-2,3-dimethoxystrychnidin-10-one; Polyamide; brucine; (-)-Brucine; Strychnidin-10-one, 2,3-dimethoxy-; Dimethoxy strychnine; Brucine



数据库引用编号

65 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

66 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, ANXA5, BCL2, CASP3, CAT, CCND1, CTNNB1, MTOR, PIK3CA, PTGS2, TNFSF11, VEGFA
Peripheral membrane protein 4 ANXA5, CYP1B1, MTOR, PTGS2
Endoplasmic reticulum membrane 4 BCL2, CYP1B1, MTOR, PTGS2
Nucleus 7 AKT1, BCL2, CASP3, CCND1, CTNNB1, MTOR, VEGFA
cytosol 10 AKT1, ANXA5, BCL2, CASP3, CAT, CCND1, CTNNB1, GPT, MTOR, PIK3CA
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 2 CCND1, CTNNB1
nucleoplasm 5 AKT1, CASP3, CCND1, CTNNB1, MTOR
Cell membrane 5 AKT1, CTNNB1, GLRA2, TNF, TNFSF11
Cytoplasmic side 1 MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
Multi-pass membrane protein 1 GLRA2
Golgi apparatus membrane 1 MTOR
Synapse 2 CTNNB1, GLRA2
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
cell surface 2 TNF, VEGFA
glutamatergic synapse 3 AKT1, CASP3, CTNNB1
Golgi apparatus 1 VEGFA
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
sarcolemma 1 ANXA5
Lysosome 1 MTOR
plasma membrane 7 AKT1, CTNNB1, GLRA2, PIK3CA, TNF, TNFRSF11B, TNFSF11
Membrane 11 AKT1, ANXA5, BCL2, CAT, COL4A1, CTNNB1, CYP1B1, GLRA2, MTOR, TNFSF11, VEGFA
axon 1 CCK
basolateral plasma membrane 1 CTNNB1
caveola 1 PTGS2
extracellular exosome 4 ANXA5, CAT, CTNNB1, GPT
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, PTGS2, VEGFA
extracellular space 7 CCK, COL4A1, IL6, TNF, TNFRSF11B, TNFSF11, VEGFA
perinuclear region of cytoplasm 2 CTNNB1, PIK3CA
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CAT, CYP1B1
protein-containing complex 5 AKT1, BCL2, CAT, CTNNB1, PTGS2
intracellular membrane-bounded organelle 3 CAT, CYP1B1, GLRA2
Microsome membrane 3 CYP1B1, MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 5 CCK, IL6, TNFRSF11B, TNFSF11, VEGFA
extracellular region 9 ANXA5, CAT, CCK, COL4A1, IL6, TNF, TNFRSF11B, TNFSF11, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
mitochondrial matrix 1 CAT
transcription regulator complex 1 CTNNB1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 2 ANXA5, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
Wnt signalosome 1 CTNNB1
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 TNF, TNFSF11
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 3 ANXA5, CAT, CTNNB1
spindle 1 AKT1
GABA-ergic synapse 1 GLRA2
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 2 TNFRSF11B, VEGFA
Peroxisome 1 CAT
basement membrane 1 COL4A1
collagen trimer 1 COL4A1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ANXA5, COL4A1
secretory granule 1 VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 GLRA2
receptor complex 1 TNFRSF11B
Zymogen granule membrane 1 ANXA5
neuron projection 2 GLRA2, PTGS2
ciliary basal body 1 AKT1
cell projection 1 GLRA2
phagocytic cup 1 TNF
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
postsynaptic density, intracellular component 1 CTNNB1
transmembrane transporter complex 1 GLRA2
microvillus membrane 1 CTNNB1
nuclear envelope 1 MTOR
Endomembrane system 2 CTNNB1, MTOR
chloride channel complex 1 GLRA2
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 3 COL4A1, IL6, PTGS2
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
beta-catenin-TCF complex 1 CTNNB1
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
presynaptic active zone cytoplasmic component 1 CTNNB1
vesicle membrane 1 ANXA5
protein-DNA complex 1 CTNNB1
death-inducing signaling complex 1 CASP3
postsynaptic specialization membrane 1 GLRA2
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
Secreted, extracellular space, extracellular matrix, basement membrane 1 COL4A1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
collagen type IV trimer 1 COL4A1
catalase complex 1 CAT
glycinergic synapse 1 GLRA2
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yong Yang, Peng Li, Xiaojia Li, Ying Zhu, Xiutian Guo. Brucine D restrains colorectal cancer tumorigenesis and autophagy by downregulating circ_0068464. Chemical biology & drug design. 2024 Jan; 103(1):e14407. doi: 10.1111/cbdd.14407. [PMID: 38040413]
  • Min Wu, Yi Hu, Mengran Xu, Lijuan Fu, Chengpan Li, Jingjing Wu, Xin Sun, Wenshen Wang, Shaozhen Wang, Ting Wang, Weiping Ding, Ping Li. Transdermal delivery of brucine-encapsulated liposomes significantly enhances anti-tumor outcomes in treating triple-negative breast cancer. Biomaterials advances. 2023 Jul; 153(?):213566. doi: 10.1016/j.bioadv.2023.213566. [PMID: 37536027]
  • Yan Gao, Lin Guo, Ying Han, Jingpu Zhang, Zhong Dai, Shuangcheng Ma. A Combination of In Silico ADMET Prediction, In Vivo Toxicity Evaluation, and Potential Mechanism Exploration of Brucine and Brucine N-oxide-A Comparative Study. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031341. [PMID: 36771007]
  • Shan Lu, Xuan-Zhong Wang, Chuan He, Lei Wang, Shi-Peng Liang, Chong-Cheng Wang, Chen Li, Tian-Fei Luo, Chun-Sheng Feng, Zhen-Chuan Wang, Guang-Fan Chi, Peng-Fei Ge. ATF3 contributes to brucine-triggered glioma cell ferroptosis via promotion of hydrogen peroxide and iron. Acta pharmacologica Sinica. 2021 Oct; 42(10):1690-1702. doi: 10.1038/s41401-021-00700-w. [PMID: 34112960]
  • Bin Liu, Yuqing Zhang, Qingke Wu, Li Wang, Bo Hu. Alleviation of isoprenaline hydrochloride induced myocardial ischemia injury by brucine through the inhibition of Na+/K+-ATPase. Experimental gerontology. 2021 07; 149(?):111332. doi: 10.1016/j.exger.2021.111332. [PMID: 33781843]
  • Lu Gao, Yanke Lin, Shuai Wang, Luomin Lin, Danyi Lu, Yue Zhao, Huijie Xing, Baojian Wu. Chronotoxicity of Semen Strychni is associated with circadian metabolism and transport in mice. The Journal of pharmacy and pharmacology. 2021 Mar; 73(3):398-409. doi: 10.1093/jpp/rgaa007. [PMID: 33793874]
  • Heba S Elsewedy, Bandar E Al Dhubiab, Mahmoud A Mahdy, Hanan M Elnahas. Development, optimization, and evaluation of PEGylated brucine-loaded PLGA nanoparticles. Drug delivery. 2020 Dec; 27(1):1134-1146. doi: 10.1080/10717544.2020.1797237. [PMID: 32729331]
  • Min Zhang, Chao Wang, Zheng-Lin Ou, Jing Wen, Hua-Lin Cai, Ping-Fei Fang. Effects of licorice extracts on the pharmacokinetics of brucine in rats and its possible mechanism. Pakistan journal of pharmaceutical sciences. 2020 Sep; 33(5):1995-2002. doi: . [PMID: 33824106]
  • Dan Lü, Qieying Jiang, Jing Zhang, Ronggui Zeng, Zhenggen Liao, Xinli Liang. Effect of Baizhu (Rhizoma Atractylodis Macrocephalae) extract on intestinal absorption of brucine and strychnine in vitro and in situ. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2020 08; 40(4):562-570. doi: 10.19852/j.cnki.jtcm.2020.04.005. [PMID: 32744023]
  • Nestor Ishimwe, Pengfei Wei, Meimei Wang, Hao Zhang, Liansheng Wang, Manman Jing, Longping Wen, Yunjiao Zhang. Autophagy Impairment through Lysosome Dysfunction by Brucine Induces Immunogenic Cell Death (ICD). The American journal of Chinese medicine. 2020; 48(8):1915-1940. doi: 10.1142/s0192415x20500962. [PMID: 33308096]
  • Min Zhang, Chao Wang, Hua-Lin Cai, Jing Wen, Ping-Fei Fang. Licorice Extracts Attenuate Nephrotoxicity Induced by Brucine Through Suppression of Mitochondria Apoptotic Pathway and STAT3 Activation. Current medical science. 2019 Dec; 39(6):890-898. doi: 10.1007/s11596-019-2126-z. [PMID: 31845219]
  • Ziyue Zhou, Yanke Lin, Lu Gao, Zemin Yang, Shuai Wang, Baojian Wu. Cyp3a11 metabolism-based chronotoxicity of brucine in mice. Toxicology letters. 2019 Oct; 313(?):188-195. doi: 10.1016/j.toxlet.2019.07.007. [PMID: 31284022]
  • Hua Ren, Jianping Zhao, Dongsheng Fan, Ze Wang, Tingjie Zhao, Yuejin Li, Yirui Zhao, David Adelson, Huiqin Hao. Alkaloids from nux vomica suppresses colon cancer cell growth through Wnt/β-catenin signaling pathway. Phytotherapy research : PTR. 2019 May; 33(5):1570-1578. doi: 10.1002/ptr.6347. [PMID: 30907037]
  • Guang Yu, Linnan Qian, Juanjuan Yu, Min Tang, Changming Wang, Yuan Zhou, Xiao Geng, Chan Zhu, Yan Yang, Yang Pan, Xu Shen, Zongxiang Tang. Brucine alleviates neuropathic pain in mice via reducing the current of the sodium channel. Journal of ethnopharmacology. 2019 Apr; 233(?):56-63. doi: 10.1016/j.jep.2018.12.045. [PMID: 30599222]
  • Meng-Ran Xu, Peng-Fei Wei, Ming-Zhu Suo, Yi Hu, Weiping Ding, Li Su, Yao-Dong Zhu, Wan-Ji Song, Guan-Hao Tang, Mei Zhang, Ping Li. Brucine Suppresses Vasculogenic Mimicry in Human Triple-Negative Breast Cancer Cell Line MDA-MB-231. BioMed research international. 2019; 2019(?):6543230. doi: 10.1155/2019/6543230. [PMID: 30723742]
  • Uma Saminathan, Pachaiappan Pugalendhi, Suganthi Subramaniyan, Rajendran Jayaganesh. Biochemical studies evaluating the chemopreventive potential of brucine in chemically induced mammary carcinogenesis of rats. Toxicology mechanisms and methods. 2019 Jan; 29(1):8-17. doi: 10.1080/15376516.2018.1502387. [PMID: 30027798]
  • Chunhua Yuan, Zhengyi Luo, Ying Zhou, Sheng Lei, Changxi Xu, Chao Peng, Shuji Li, Xiaowen Li, Xinhong Zhu, Tianming Gao. Removal of hERG potassium channel affinity through introduction of an oxygen atom: Molecular insights from structure-activity relationships of strychnine and its analogs. Toxicology and applied pharmacology. 2018 12; 360(?):109-119. doi: 10.1016/j.taap.2018.09.042. [PMID: 30282042]
  • Jian-Bo Ma, Hai-Wen Qiu, Qiu-Hong Rui, Yu-Feng Liao, Yan-Min Chen, Jin Xu, Yun Zhang, Yan Zhu, Yong-Gang Zhao. Enhanced cleanup efficiency hydroxy functionalized-magnetic graphene oxide and its comparison with magnetic carboxyl-graphene for PRiME pass-through cleanup of strychnine and brucine in human plasma samples. Analytica chimica acta. 2018 Aug; 1020(?):41-50. doi: 10.1016/j.aca.2018.03.008. [PMID: 29655427]
  • Tiankun Ren, Menglin Li, Hao Zheng, Wenwei Liu, Jinlan Zhang. Microdialysis combined with RRLC-MS/MS for the pharmacokinetics of two major alkaloids of Bi qi capsule and the potential roles of P-gp and BCRP on their penetration. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 Aug; 1092(?):72-81. doi: 10.1016/j.jchromb.2018.05.048. [PMID: 29883892]
  • Xianpeng Shi, Man Zhu, Yuan Kang, Tianfeng Yang, Xia Chen, Yanmin Zhang. Wnt/β-catenin signaling pathway is involved in regulating the migration by an effective natural compound brucine in LoVo cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jul; 46(?):85-92. doi: 10.1016/j.phymed.2018.04.019. [PMID: 30097126]
  • Shujuan Li, Yanjie Chu, Ruowen Zhang, Linjia Sun, Xiaohui Chen. Prophylactic Neuroprotection of Total Glucosides of Paeoniae Radix Alba against Semen Strychni-Induced Neurotoxicity in Rats: Suppressing Oxidative Stress and Reducing the Absorption of Toxic Components. Nutrients. 2018 Apr; 10(4):. doi: 10.3390/nu10040514. [PMID: 29677121]
  • Hao Zheng, Zhe Wang, Wenwei Liu, Hongtao Jin, Jinlan Zhang. Toxicokinetics of strychnine and brucine after the oral administration of Biqi capsule to rats by RRLC-MS/MS. Biomedical chromatography : BMC. 2018 Mar; 32(3):. doi: 10.1002/bmc.4117. [PMID: 29027676]
  • Min Zhang, Yang Deng, Chao Wang, Hua-Lin Cai, Jing Wen, Ping-Fei Fang, Bi-Kui Zhang, Huan-De Li, Miao Yan. An LC-MS/MS method for determination of bioactive components of liquorice and Semen Strychni in rat plasma: Application to a pharmacokinetics study. Drug testing and analysis. 2018 Feb; 10(2):262-271. doi: 10.1002/dta.2210. [PMID: 28447397]
  • Rutesh Savalia, Sanghamitra Chatterjee. Sensitive detection of brucine an anti-metastatic drug for hepatocellular carcinoma at carbon nanotubes - nafion composite based biosensor. Biosensors & bioelectronics. 2017 Dec; 98(?):371-377. doi: 10.1016/j.bios.2017.07.011. [PMID: 28709086]
  • P N Prasad Maddisetty, V A Doss, Mohanasundaram S, Srinivasarao V, Mohanbabu T. HPLC and GC-MS: Identification and Quantification of Strychnine and Brucine in Strychnos nux-vomica leaves. Pakistan journal of pharmaceutical sciences. 2017 Nov; 30(6(Supplementary)):2369-2373. doi: . [PMID: 29188771]
  • Ping Wu, Qin Liang, Pei Feng, Chunyan Li, Chunguang Yang, Hongsuo Liang, Huaibo Tang, Cijun Shuai. A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities. International journal of molecular sciences. 2017 Apr; 18(4):. doi: 10.3390/ijms18040757. [PMID: 28368343]
  • Nongshan Zhang, Yiyun Wu, Runlin Xing, Bo Xu, Dai Guoliang, Peimin Wang. Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine. BioMed research international. 2017; 2017(?):3273816. doi: 10.1155/2017/3273816. [PMID: 29349071]
  • Wei Gu, Dongyue Wang, Zihao Pan, Xiao Liu, Baochang Cai, Jun Chen. Ultra-performance liquid chromatography-tandem mass spectrometric assay for the simultaneous determination of brucine, strychnine and brucine N-oxide in rat plasma: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2016 Jul; 30(7):1097-1103. doi: 10.1002/bmc.3656. [PMID: 26578094]
  • Jun Guo, Hua Meng, Huang Huang Li, Qiao Feng Wang. Determination of strychnine, brucine, strychnine N-oxide, and brucine N-oxide in plasma samples after the oral administration of processed semen strychni extract by high-performance liquid chromatography with ultrasound-assisted mixed cloud point extraction. Journal of separation science. 2016 Jul; 39(13):2553-61. doi: 10.1002/jssc.201501379. [PMID: 27125604]
  • Aihua Lin, Xiaochun Su, Dan She, Kuncheng Qiu, Qianmei He, Yiming Liu. LC-MS/MS determination and comparative pharmacokinetics of strychnine, brucine and their metabolites in rat plasma after intragastric administration of each monomer and the total alkaloids from Semen Strychni. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jan; 1008(?):65-73. doi: 10.1016/j.jchromb.2015.11.012. [PMID: 26625339]
  • Ruo-xuan Liu, Li-ming Li, Fei Wu, A-rong Li, Xia-wen Liu, Jie-wen Guo. [Pharmacokinetic Study on Brucine in Different Administration Methods of Liposome in Rats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Oct; 38(10):2125-8. doi: NULL. [PMID: 27254928]
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  • Zhipeng Chen, Liujie Zhang, Yang Song, Jiayu He, Li Wu, Can Zhao, Yanyu Xiao, Wei Li, Baochang Cai, Haibo Cheng, Weidong Li. Hierarchical targeted hepatocyte mitochondrial multifunctional chitosan nanoparticles for anticancer drug delivery. Biomaterials. 2015 Jun; 52(?):240-50. doi: 10.1016/j.biomaterials.2015.02.001. [PMID: 25818430]
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