Ginsenoside Rg3 (BioDeep_00000000280)

Main id: BioDeep_00001867483

 

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C42H72O13 (784.4972662)
中文名称: 人参皂甙 Rg3, 人参皂苷 Rg3, 人参皂苷Rg3, 20(S)-人参皂苷 Rg3
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(C)(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]([C@](O)(C)CC/C=C(\C)/C)([H])[C@@]4([H])[C@H](O)C[C@]3([H])[C@@]12C
InChI: InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3

描述信息

(20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.
Ginsenoside Rg3 is a natural product found in Panax ginseng, Panax notoginseng, and other organisms with data available.
(20R)-Ginsenoside Rg3 is found in tea. (20R)-Ginsenoside Rg3 is isolated from Panax ginseng (ginseng).
D000970 - Antineoplastic Agents
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

同义名列表

37 个代谢物同义名

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; 2-[(4,5-dihydroxy-2-{[16-hydroxy-14-(2-hydroxy-6-methylhept-5-en-2-yl)-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-yl]oxy}-6-(hydroxymethyl)oxan-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-12,20-DIHYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; beta-D-Glucopyranoside, (3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; beta-D-glucopyranoside, (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; 3-O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-.BETA.-D-GLUCOPYRANOSYLDAMMAR-24-ENE-3.BETA.,12.BETA.,20S-TRIOL; (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; Dammar-24-ene-12-beta,20-diol, 3-beta-((2-O-beta-D-glucopyranosyl-beta-D-glucopyransoyl)oxy)-; dammar-24-ene-12beta,20-diol, 3-beta-((2-O-beta-D-glucopyranosyl-beta-D-glucopyransoyl)oxy)-; 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranosyldammar-24-ene-3beta,12beta,20s-triol; 12beta,20S-dihydroxydammar-24-en-3beta-yl 2-O-betaD-glucopyranosyl-beta-D-glucopyranoside; 20(S)-Propanaxadiol;S-ginsenoside Rg3; Ginsenoside Rg3, analytical standard; Ginsenoside Rg3, >=98\\% (HPLC); RWXIFXNRCLMQCD-JBVRGBGGSA-N; GINSENOSIDE RG3 [WHO-DD]; 20(S)-ginsenoside Rg(3); 20(R)-ginsenoside Rg(3); ginsenoside rg3, (+)-; 20(S)-Ginsenoside-Rg3; ginsenoside rg3, (s)-; 20(S)-Ginsenoside Rg3; (20S)-ginsenoside Rg3; Ginsenoside Rg3,(S); 20s-ginsenoside rg3; (20S)-Propanaxadiol; 20(S)-Propanaxidiol; ginsenoside 20-rg3; (R)Ginsenoside-Rg3; s-ginsenoside rg3; ginsenoside Rg(3); 20S-propanaxadiol; Ginsenoside Rg3; ginsenoside-rg3; Ginsenoside; Rg3; 20(S)-Propanaxadiol



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(1)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • An-Qi Wang, Ya-Jie Wang, Jing Zhang, Yi-Ming Fan, Shi-Yang Li, Li-Wei Zou. Comparative study on inhibitory effects of ginsenosides on human pancreatic lipase and porcine pancreatic lipase: structure-activity relationships and inhibitory mechanism. Natural product research. 2024 Jun; 38(12):2031-2039. doi: 10.1080/14786419.2023.2235713. [PMID: 37471672]
  • Fang Feng, Hyun-A Ko, Thi My Tien Truong, Woo-Jin Song, Eun-Ju Ko, Inhae Kang. Ginsenoside Rg3, enriched in red ginseng extract, improves lipopolysaccharides-induced suppression of brown and beige adipose thermogenesis with mitochondrial activation. Scientific reports. 2024 04; 14(1):9157. doi: 10.1038/s41598-024-59758-1. [PMID: 38644456]
  • Xufan Cai, Zhaohong Wang, Shengzhang Lin, Hui Chen, Heqi Bu. Ginsenoside Rg3 suppresses vasculogenic mimicry by impairing DVL3-maintained stemness via PAAD cell-derived exosomal miR-204 in pancreatic adenocarcinoma. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155402. doi: 10.1016/j.phymed.2024.155402. [PMID: 38350242]
  • Yuhang Hu, Zhichao Lang, Xinmiao Li, Lifan Lin, Yifei Li, Rongrong Zhang, Jianjian Zheng, Zhengping Yu. Ginsenoside Rg3 promotes hepatic stellate cell ferroptosis by epigenetically regulating ACSL4 to suppress liver fibrosis progression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155289. doi: 10.1016/j.phymed.2023.155289. [PMID: 38176269]
  • Jie Chen, Bin Zhang, Liwei Wu, Jiabin Xu. Ginsenoside Rg3 exhibits anti-catabolic and anti-apoptotic effects in IL-1β treated human disc nucleus pulposus cells and in a rat model of disc degeneration by inactivating the MAPK pathway. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Jan; 70(1):233-238. doi: 10.14715/cmb/2024.70.1.32. [PMID: 38372089]
  • Chenyang Zhang, Huifang Yu, Jingxue Ye, Hongna Tong, Min Wang, Guibo Sun. Ginsenoside Rg3 Protects against Diabetic Cardiomyopathy and Promotes Adiponectin Signaling via Activation of PPAR-γ. International journal of molecular sciences. 2023 Nov; 24(23):. doi: 10.3390/ijms242316736. [PMID: 38069059]
  • Jiaxuan Xia, Chen Chen, Meichen Dong, Ying Zhu, Anni Wang, Shiyi Li, Ru Zhang, Chunbo Feng, Xinnan Jiang, Xinchun Xu, Jianxin Wang. Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance. Journal of controlled release : official journal of the Controlled Release Society. 2023 Oct; 364(?):23-36. doi: 10.1016/j.jconrel.2023.10.023. [PMID: 37863358]
  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Jiali Yang, Lifeng Zhang, Xiaojuan Peng, Shuai Zhang, Shuwen Sun, Qiteng Ding, Chuanbo Ding, Wencong Liu. Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28135066. [PMID: 37446725]
  • Song Gao, Cancan Fang, Tiancheng Wang, Wenjie Lu, Nan Wang, Lingfeng Sun, Wenyou Fang, Yang Chen, Rongfeng Hu. The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer: A systematic review and meta-analysis of randomized controlled trials. Medicine. 2023 Apr; 102(14):e33463. doi: 10.1097/md.0000000000033463. [PMID: 37026927]
  • Guangyuan Hu, Na Luo, Qiuyun Guo, Dingkun Wang, Ping Peng, Dongbo Liu, Shunfang Liu, Linli Zhang, Guoxian Long, Wei Sun. Ginsenoside Rg3 Sensitizes Nasopharyngeal Carcinoma Cells to Radiation by Suppressing Epithelial Mesenchymal Transition. Radiation research. 2023 Mar; ?(?):. doi: 10.1667/rade-22-00183.1. [PMID: 36946792]
  • Jie Xiong, Hongmei Yuan, Shihong Fei, Shengli Yang, Ming You, Li Liu. The preventive role of the red gingeng ginsenoside Rg3 in the treatment of lung tumorigenesis induced by benzo(a)pyrene. Scientific reports. 2023 Mar; 13(1):4528. doi: 10.1038/s41598-023-31710-9. [PMID: 36941308]
  • Shicheng Bi, Jianjian Shao, Yiwen Qu, Wei Xu, Jun Li, Li Zhang, Wanyu Shi, Liting Cao. Serum metabolomics reveal pathways associated with protective effect of ginsenoside Rg3 on immune stress. Poultry science. 2022 Dec; 101(12):102187. doi: 10.1016/j.psj.2022.102187. [PMID: 36215740]
  • Junwen Chen, Jinlian Chen, Zhanwen Wang, Chengchun Chen, Jinxin Zheng, Zhijian Yu, Qiwen Deng, Yuxi Zhao, Zewen Wen. 20S-ginsenoside Rg3 inhibits the biofilm formation and haemolytic activity of Staphylococcus aureus by inhibiting the SaeR/SaeS two-component system. Journal of medical microbiology. 2022 Oct; 71(10):. doi: 10.1099/jmm.0.001587. [PMID: 36288093]
  • Jiaxuan Xia, Shuya Zhang, Ru Zhang, Anni Wang, Ying Zhu, Meichen Dong, Shaojie Ma, Chao Hong, Shengyao Liu, Dan Wang, Jianxin Wang. Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes. Journal of nanobiotechnology. 2022 Sep; 20(1):414. doi: 10.1186/s12951-022-01623-2. [PMID: 36109762]
  • Lu Yao, Huanyu Zhang, Yirong Liu, Qiushuang Ji, Jing Xie, Ru Zhang, Luqi Huang, Kunrong Mei, Juan Wang, Wenyuan Gao. Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis. Journal of integrative plant biology. 2022 Sep; 64(9):1739-1754. doi: 10.1111/jipb.13315. [PMID: 35731022]
  • Qiong Lai, Fu-Ming Liu, Wang-Lin Rao, Guang-Ying Yuan, Zhao-Yang Fan, Lu Zhang, Fei Fu, Jun-Ping Kou, Bo-Yang Yu, Fang Li. Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure. Acta pharmacologica Sinica. 2022 Aug; 43(8):2003-2015. doi: 10.1038/s41401-021-00830-1. [PMID: 34916608]
  • Geyuan Qi, Baoyu Ji, Yanan Zhang, Luqi Huang, Juan Wang, Wenyuan Gao. Microbiome-based screening and co-fermentation of rhizospheric microorganisms for highly ginsenoside Rg3 production. Microbiological research. 2022 Aug; 261(?):127054. doi: 10.1016/j.micres.2022.127054. [PMID: 35598356]
  • Shangbin Lv, Xiaodong Chen, Yu Chen, Daoyin Gong, Gang Mao, Caifei Shen, Ting Xia, Jing Cheng, Zhaoliang Luo, Yu Cheng, Weihong Li, Jinhao Zeng. Ginsenoside Rg3 induces apoptosis and inhibits proliferation by down-regulating TIGAR in rats with gastric precancerous lesions. BMC complementary medicine and therapies. 2022 Jul; 22(1):188. doi: 10.1186/s12906-022-03669-z. [PMID: 35840932]
  • Jiaxuan Xia, Shaojie Ma, Xi Zhu, Chen Chen, Ru Zhang, Zhonglian Cao, Xing Chen, Longlong Zhang, Ying Zhu, Shuya Zhang, Shiyi Li, Guolong Gu, Xunbin Wei, Kunqian Yu, Jianxin Wang. Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches. Science advances. 2022 02; 8(6):eabj1262. doi: 10.1126/sciadv.abj1262. [PMID: 35148178]
  • Zhongzhen Zeng, Qing Nian, Nianzhi Chen, Maoyuan Zhao, Qiao Zheng, Gang Zhang, Ziyi Zhao, Yu Chen, Jundong Wang, Jinhao Zeng, Daoyin Gong, Jianyuan Tang. Ginsenoside Rg3 inhibits angiogenesis in gastric precancerous lesions through downregulation of Glut1 and Glut4. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112086. doi: 10.1016/j.biopha.2021.112086. [PMID: 34799220]
  • Tehasi Wang, Chengguang Zhang, Shuren Wang. Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner. Journal of orthopaedic surgery and research. 2021 Dec; 16(1):724. doi: 10.1186/s13018-021-02868-7. [PMID: 34930332]
  • Zhongjian Pu, Fei Ge, Yajun Wang, Ziyu Jiang, Shilin Zhu, Shukui Qin, Qijun Dai, Hua Liu, Haiqing Hua. Ginsenoside-Rg3 inhibits the proliferation and invasion of hepatoma carcinoma cells via regulating long non-coding RNA HOX antisense intergenic. Bioengineered. 2021 12; 12(1):2398-2409. doi: 10.1080/21655979.2021.1932211. [PMID: 34130594]
  • Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu. Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22896. doi: 10.1002/jbt.22896. [PMID: 34423507]
  • Zhihao Liu, Xiyun Bian, Wenbo Gao, Jing Su, Chuanrui Ma, Xiaolin Xiao, Tian Yu, Han Zhang, Xiaozhi Liu, Guanwei Fan. Rg3 promotes the SUMOylation of SERCA2a and corrects cardiac dysfunction in heart failure. Pharmacological research. 2021 10; 172(?):105843. doi: 10.1016/j.phrs.2021.105843. [PMID: 34428586]
  • Dingqi Zhang, Sami Hamdoun, Ruihong Chen, Lijun Yang, Chi Kio Ip, Yuanqing Qu, Runfeng Li, Haiming Jiang, Zifeng Yang, Sookja Kim Chung, Liang Liu, Vincent Kam Wai Wong. Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry. Pharmacological research. 2021 10; 172(?):105820. doi: 10.1016/j.phrs.2021.105820. [PMID: 34403732]
  • Manying Wang, Rui Jiang, Jianzeng Liu, Xiaohao Xu, Guang Sun, Daqing Zhao, Liwei Sun. 20(s)‑ginseonside‑Rg3 modulation of AMPK/FoxO3 signaling to attenuate mitochondrial dysfunction in a dexamethasone‑injured C2C12 myotube‑based model of skeletal atrophy in vitro. Molecular medicine reports. 2021 05; 23(5):. doi: 10.3892/mmr.2021.11945. [PMID: 33649814]
  • Ying Li, Jin-Gang Hou, Zhi Liu, Xiao-Jie Gong, Jun-Nan Hu, Ying-Ping Wang, Wen-Cong Liu, Xiang-Hui Lin, Zi Wang, Wei Li. Alleviative effects of 20(R)-Rg3 on HFD/STZ-induced diabetic nephropathy via MAPK/NF-κB signaling pathways in C57BL/6 mice. Journal of ethnopharmacology. 2021 Mar; 267(?):113500. doi: 10.1016/j.jep.2020.113500. [PMID: 33091499]
  • Zongyu Liu, Tongjun Liu, Wei Li, Jiannan Li, Cuizhu Wang, Kai Zhang. Insights into the antitumor mechanism of ginsenosides Rg3. Molecular biology reports. 2021 Mar; 48(3):2639-2652. doi: 10.1007/s11033-021-06187-2. [PMID: 33661439]
  • Ying Zhu, Jianming Liang, Caifang Gao, Anni Wang, Jiaxuan Xia, Chao Hong, Zhirong Zhong, Zhong Zuo, Jisu Kim, Hongwei Ren, Shiyi Li, Qi Wang, Fengxue Zhang, Jianxin Wang. Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy. Journal of controlled release : official journal of the Controlled Release Society. 2021 02; 330(?):641-657. doi: 10.1016/j.jconrel.2020.12.036. [PMID: 33359582]
  • Jun-Jie Zhang, Yan-Dan Zhou, Yong-Bo Liu, Jian-Qiang Wang, Ke-Ke Li, Xiao-Jie Gong, Xiang-Hui Lin, Ying-Ping Wang, Zi Wang, Wei Li. Protective Effect of 20(R)-Ginsenoside Rg3 Against Cisplatin-Induced Renal Toxicity via PI3K/AKT and NF-[Formula: see text]B Signaling Pathways Based on the Premise of Ensuring Anticancer Effect. The American journal of Chinese medicine. 2021; 49(7):1739-1756. doi: 10.1142/s0192415x21500828. [PMID: 34461812]
  • Miao Song, Fubo Jia, Zheng Cao, Haiyang Zhang, Menglin Liu, Li Gao. Ginsenoside Rg3 Attenuates Aluminum-Induced Osteoporosis Through Regulation of Oxidative Stress and Bone Metabolism in Rats. Biological trace element research. 2020 Dec; 198(2):557-566. doi: 10.1007/s12011-020-02089-9. [PMID: 32173789]
  • Jin Ha Lee, Ji Young Oh, Soo Hyun Kim, In Jeong Oh, Yong-Ho Lee, Keun Woo Lee, Woong Hee Lee, Jeong-Hwan Kim. Pharmaceutical Efficacy of Gypenoside LXXV on Non-Alcoholic Steatohepatitis (NASH). Biomolecules. 2020 10; 10(10):. doi: 10.3390/biom10101426. [PMID: 33050067]
  • Manying Wang, Jixiang Ren, Xuenan Chen, Jianzeng Liu, Xiaohao Xu, Xiangyan Li, Daqing Zhao, Liwei Sun. 20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway. Biochemical pharmacology. 2020 10; 180(?):114145. doi: 10.1016/j.bcp.2020.114145. [PMID: 32653593]
  • Shumin Jiang, Xueli Wu, Yi Wang, Jingtao Zou, Xiaoping Zhao. The potential DPP-4 inhibitors from Xiao-Ke-An improve the glucolipid metabolism via the activation of AKT/GSK-3β pathway. European journal of pharmacology. 2020 Sep; 882(?):173272. doi: 10.1016/j.ejphar.2020.173272. [PMID: 32535096]
  • S Zhang, J Luo, J Xie, Z Wang, W Xiao, L Zhao. Cooperated biotransformation of ginsenoside extracts into ginsenoside 20(S)-Rg3 by three thermostable glycosidases. Journal of applied microbiology. 2020 Mar; 128(3):721-734. doi: 10.1111/jam.14513. [PMID: 31715079]
  • Elena Jovanovski, Lea-Duvnjak-Smircic, Allison Komishon, Fei Au-Yeung, Andreea Zurbau, Alexandra L Jenkins, Mi-Kyung Sung, Robert Josse, Vladimir Vuksan. Vascular effects of combined enriched Korean Red ginseng (Panax Ginseng) and American ginseng (Panax Quinquefolius) administration in individuals with hypertension and type 2 diabetes: A randomized controlled trial. Complementary therapies in medicine. 2020 Mar; 49(?):102338. doi: 10.1016/j.ctim.2020.102338. [PMID: 32147072]
  • Kyungtae Kim, Ki Hong Nam, Sang Ah Yi, Jong Woo Park, Jeung-Whan Han, Jaecheol Lee. Ginsenoside Rg3 Induces Browning of 3T3-L1 Adipocytes by Activating AMPK Signaling. Nutrients. 2020 Feb; 12(2):. doi: 10.3390/nu12020427. [PMID: 32046061]
  • Yonglin Gao, Guangfei Wang, Tong Wang, Guisheng Li, Jian Lin, Liqin Sun, Xuran Wu, Xilin Sun, Hongbo Wang, Chunmei Li, Jingwei Tian, Jing Zhu, Kezhou Wang, Susan Cho. A 26-week 20(S)-ginsenoside Rg3 oral toxicity study in Beagle dogs. Regulatory toxicology and pharmacology : RTP. 2020 Feb; 110(?):104522. doi: 10.1016/j.yrtph.2019.104522. [PMID: 31726191]
  • Ji-Hyeon Jeon, Sowon Lee, Wonpyo Lee, Sojeong Jin, Mihwa Kwon, Chul Hwi Shin, Min-Koo Choi, Im-Sook Song. Herb-Drug Interaction of Red Ginseng Extract and Ginsenoside Rc with Valsartan in Rats. Molecules (Basel, Switzerland). 2020 Jan; 25(3):. doi: 10.3390/molecules25030622. [PMID: 32023909]
  • Stephen Wright, Elliot Altman. Inhibition of Herpes Simplex Viruses, Types 1 and 2, by Ginsenoside 20(S)-Rg3. Journal of microbiology and biotechnology. 2020 Jan; 30(1):101-108. doi: 10.4014/jmb.1908.08047. [PMID: 31693840]
  • Jinjing Wang, Fanghua Qi, Zhixue Wang, Zhikun Zhang, Ni Pan, Lei Huai, Shuyu Qu, Lin Zhao. A review of traditional Chinese medicine for treatment of glioblastoma. Bioscience trends. 2020 Jan; 13(6):476-487. doi: 10.5582/bst.2019.01323. [PMID: 31866614]
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