Ginsenoside Rg3 (BioDeep_00000000280)

   

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C42H72O13 (784.4973)
中文名称: 人参皂甙 Rg3, 人参皂苷 Rg3, 人参皂苷Rg3, 20(S)-人参皂苷 Rg3
谱图信息: 最多检出来源 Viridiplantae(plant) 19.14%

分子结构信息

SMILES: C1C[C@H](O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(C)(C)[C@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]([C@](O)(C)CC/C=C(\C)/C)([H])[C@@]4([H])[C@H](O)C[C@]3([H])[C@@]12C
InChI: InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3

描述信息

(20S)-ginsenoside Rg3 is a ginsenoside found in Panax ginseng and Panax japonicus var. major that is dammarane which is substituted by hydroxy groups at the 3beta, 12beta and 20 pro-S positions, in which the hydroxy group at position 3 has been converted to the corresponding beta-D-glucopyranosyl-beta-D-glucopyranoside, and in which a double bond has been introduced at the 24-25 position. It has a role as an apoptosis inducer, an antineoplastic agent, a plant metabolite and an angiogenesis modulating agent. It is a ginsenoside, a tetracyclic triterpenoid and a glycoside. It is functionally related to a (20S)-protopanaxadiol. It derives from a hydride of a dammarane.
Ginsenoside Rg3 is a natural product found in Panax ginseng, Panax notoginseng, and other organisms with data available.
(20R)-Ginsenoside Rg3 is found in tea. (20R)-Ginsenoside Rg3 is isolated from Panax ginseng (ginseng).
D000970 - Antineoplastic Agents
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.
20(S)-Ginsenoside Rg3 is the main component of Panax ginseng C. A. Meyer. Ginsenoside Rg3 inhibits Na+ and hKv1.4 channel with IC50s of 32.2±4.5 and 32.6±2.2 μM, respectively. 20(S)-Ginsenoside Rg3 also inhibits Aβ levels, NF-κB activity, and COX-2 expression.

同义名列表

37 个代谢物同义名

(2S,3R,4S,5S,6R)-2-[(2R,3R,4S,5S,6R)-4,5-dihydroxy-2-[[(3S,5R,8R,9R,10R,12R,13R,14R,17S)-12-hydroxy-17-[(2S)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-6-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol; 2-[(4,5-dihydroxy-2-{[16-hydroxy-14-(2-hydroxy-6-methylhept-5-en-2-yl)-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-5-yl]oxy}-6-(hydroxymethyl)oxan-3-yl)oxy]-6-(hydroxymethyl)oxane-3,4,5-triol; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,12.BETA.)-12,20-DIHYDROXYDAMMAR-24-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANOSYL-; beta-D-Glucopyranoside, (3-beta,12-beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; beta-D-glucopyranoside, (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-; 3-O-.BETA.-D-GLUCOPYRANOSYL-(1->2)-.BETA.-D-GLUCOPYRANOSYLDAMMAR-24-ENE-3.BETA.,12.BETA.,20S-TRIOL; (3beta,12beta)-12,20-dihydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside; Dammar-24-ene-12-beta,20-diol, 3-beta-((2-O-beta-D-glucopyranosyl-beta-D-glucopyransoyl)oxy)-; dammar-24-ene-12beta,20-diol, 3-beta-((2-O-beta-D-glucopyranosyl-beta-D-glucopyransoyl)oxy)-; 3-O-beta-D-glucopyranosyl-(1->2)-beta-D-glucopyranosyldammar-24-ene-3beta,12beta,20s-triol; 12beta,20S-dihydroxydammar-24-en-3beta-yl 2-O-betaD-glucopyranosyl-beta-D-glucopyranoside; 20(S)-Propanaxadiol;S-ginsenoside Rg3; Ginsenoside Rg3, analytical standard; Ginsenoside Rg3, >=98\\% (HPLC); RWXIFXNRCLMQCD-JBVRGBGGSA-N; GINSENOSIDE RG3 [WHO-DD]; 20(S)-ginsenoside Rg(3); 20(R)-ginsenoside Rg(3); ginsenoside rg3, (+)-; 20(S)-Ginsenoside-Rg3; ginsenoside rg3, (s)-; 20(S)-Ginsenoside Rg3; (20S)-ginsenoside Rg3; Ginsenoside Rg3,(S); 20s-ginsenoside rg3; (20S)-Propanaxadiol; 20(S)-Propanaxidiol; ginsenoside 20-rg3; (R)Ginsenoside-Rg3; s-ginsenoside rg3; ginsenoside Rg(3); 20S-propanaxadiol; Ginsenoside Rg3; ginsenoside-rg3; Ginsenoside; Rg3; 20(S)-Propanaxadiol



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(1)

代谢反应

5 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(3)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

27 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, ANXA5, BCL2, CASP3, CDH1, EGFR, MAPK14, MAPK8, MTOR, NLRP3, PPARG, PRKAA2, SIRT1, VIM
Peripheral membrane protein 2 ANXA5, MTOR
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 5 BCL2, CD4, EGFR, HMOX1, MTOR
Nucleus 14 AKT1, BCL2, CASP3, CDH1, EGFR, GABPA, HMOX1, MAPK14, MAPK8, MTOR, NLRP3, PPARG, PRKAA2, SIRT1
cytosol 14 AKT1, ANXA5, BCL2, CASP3, CDH1, HMOX1, MAPK14, MAPK8, MTOR, NLRP3, PPARG, PRKAA2, SIRT1, VIM
dendrite 2 MTOR, PRKAA2
phagocytic vesicle 2 MTOR, VIM
trans-Golgi network 1 CDH1
nucleoplasm 11 AKT1, CASP3, CDH1, GABPA, HMOX1, MAPK14, MAPK8, MTOR, PPARG, PRKAA2, SIRT1
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 6 AKT1, CD4, CD8A, CDH1, EGFR, VIM
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 2 AKT1, CDH1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Golgi apparatus membrane 2 MTOR, NLRP3
Synapse 1 MAPK8
cell cortex 1 AKT1
cell junction 2 CDH1, EGFR
cell surface 1 EGFR
glutamatergic synapse 5 AKT1, CASP3, CDH1, EGFR, MAPK14
Golgi apparatus 2 CDH1, PRKAA2
Golgi membrane 3 EGFR, MTOR, NLRP3
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, PRKAA2
postsynapse 2 AKT1, CDH1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NLRP3
Lysosome 1 MTOR
endosome 2 CDH1, EGFR
plasma membrane 6 AKT1, CD4, CD8A, CDH1, EGFR, VIM
Membrane 9 AKT1, ANXA5, BCL2, CDH1, EGFR, HMOX1, MTOR, NLRP3, PRKAA2
apical plasma membrane 1 EGFR
axon 4 CCK, MAPK8, PRKAA2, VIM
basolateral plasma membrane 1 EGFR
extracellular exosome 3 ANXA5, CDH1, VIM
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, HMOX1, NLRP3
extracellular space 4 CCK, EGFR, HMOX1, IL6
perinuclear region of cytoplasm 4 CDH1, EGFR, HMOX1, PPARG
adherens junction 1 CDH1
mitochondrion 4 BCL2, MAPK14, NLRP3, SIRT1
protein-containing complex 3 AKT1, BCL2, EGFR
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 4 CD4, CD8A, CDH1, EGFR
Secreted 3 CCK, IL6, NLRP3
extracellular region 7 ANXA5, CCK, CD8A, CDH1, IL6, MAPK14, NLRP3
cytoplasmic side of plasma membrane 1 CDH1
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
[Isoform 2]: Secreted 1 CD8A
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CDH1, EGFR
external side of plasma membrane 3 ANXA5, CD4, CD8A
actin cytoskeleton 1 CDH1
microtubule cytoskeleton 1 AKT1
nucleolus 1 SIRT1
Early endosome 1 CD4
cell-cell junction 1 AKT1
vesicle 1 AKT1
heterochromatin 1 SIRT1
Membrane raft 2 CD4, EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 VIM
focal adhesion 3 ANXA5, EGFR, VIM
spindle 1 AKT1
Cell junction, adherens junction 1 CDH1
flotillin complex 1 CDH1
Peroxisome 1 VIM
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, SIRT1
PML body 2 MTOR, SIRT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
intermediate filament 1 VIM
lateral plasma membrane 1 CDH1
nuclear speck 2 MAPK14, PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
nuclear inner membrane 1 SIRT1
receptor complex 3 CD8A, EGFR, PPARG
Zymogen granule membrane 1 ANXA5
neuron projection 1 VIM
ciliary basal body 1 AKT1
chromatin 3 GABPA, PPARG, SIRT1
cell leading edge 1 VIM
cytoskeleton 1 VIM
Golgi apparatus, trans-Golgi network 1 CDH1
spindle pole 1 MAPK14
fibrillar center 1 SIRT1
nuclear envelope 2 MTOR, SIRT1
Endomembrane system 2 MTOR, NLRP3
microtubule organizing center 2 NLRP3, VIM
cytoplasmic stress granule 1 PRKAA2
euchromatin 1 SIRT1
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 VIM
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 CD4, IL6
nuclear matrix 1 VIM
anaphase-promoting complex 1 CDH1
Single-pass type IV membrane protein 1 HMOX1
Nucleus matrix 1 VIM
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 2 CD4, EGFR
[Isoform 2]: Nucleus 1 CDH1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
apical junction complex 1 CDH1
[Isoform 1]: Cell membrane 1 CD8A
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
Cell junction, desmosome 1 CDH1
desmosome 1 CDH1
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CDH1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
T cell receptor complex 2 CD4, CD8A
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • An-Qi Wang, Ya-Jie Wang, Jing Zhang, Yi-Ming Fan, Shi-Yang Li, Li-Wei Zou. Comparative study on inhibitory effects of ginsenosides on human pancreatic lipase and porcine pancreatic lipase: structure-activity relationships and inhibitory mechanism. Natural product research. 2024 Jun; 38(12):2031-2039. doi: 10.1080/14786419.2023.2235713. [PMID: 37471672]
  • Fang Feng, Hyun-A Ko, Thi My Tien Truong, Woo-Jin Song, Eun-Ju Ko, Inhae Kang. Ginsenoside Rg3, enriched in red ginseng extract, improves lipopolysaccharides-induced suppression of brown and beige adipose thermogenesis with mitochondrial activation. Scientific reports. 2024 04; 14(1):9157. doi: 10.1038/s41598-024-59758-1. [PMID: 38644456]
  • Xufan Cai, Zhaohong Wang, Shengzhang Lin, Hui Chen, Heqi Bu. Ginsenoside Rg3 suppresses vasculogenic mimicry by impairing DVL3-maintained stemness via PAAD cell-derived exosomal miR-204 in pancreatic adenocarcinoma. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155402. doi: 10.1016/j.phymed.2024.155402. [PMID: 38350242]
  • Yuhang Hu, Zhichao Lang, Xinmiao Li, Lifan Lin, Yifei Li, Rongrong Zhang, Jianjian Zheng, Zhengping Yu. Ginsenoside Rg3 promotes hepatic stellate cell ferroptosis by epigenetically regulating ACSL4 to suppress liver fibrosis progression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155289. doi: 10.1016/j.phymed.2023.155289. [PMID: 38176269]
  • Jie Chen, Bin Zhang, Liwei Wu, Jiabin Xu. Ginsenoside Rg3 exhibits anti-catabolic and anti-apoptotic effects in IL-1β treated human disc nucleus pulposus cells and in a rat model of disc degeneration by inactivating the MAPK pathway. Cellular and molecular biology (Noisy-le-Grand, France). 2024 Jan; 70(1):233-238. doi: 10.14715/cmb/2024.70.1.32. [PMID: 38372089]
  • Chenyang Zhang, Huifang Yu, Jingxue Ye, Hongna Tong, Min Wang, Guibo Sun. Ginsenoside Rg3 Protects against Diabetic Cardiomyopathy and Promotes Adiponectin Signaling via Activation of PPAR-γ. International journal of molecular sciences. 2023 Nov; 24(23):. doi: 10.3390/ijms242316736. [PMID: 38069059]
  • Jiaxuan Xia, Chen Chen, Meichen Dong, Ying Zhu, Anni Wang, Shiyi Li, Ru Zhang, Chunbo Feng, Xinnan Jiang, Xinchun Xu, Jianxin Wang. Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance. Journal of controlled release : official journal of the Controlled Release Society. 2023 Oct; 364(?):23-36. doi: 10.1016/j.jconrel.2023.10.023. [PMID: 37863358]
  • Jingyuan Zeng, Xican Li, Rongxin Cai, Ban Chen, Chunhou Li, Qingzhong Hu, Yue Sun. Proposing anti-counterfeiting pharmacopoeia quality markers for Shenlingbaizhu granule based on UHPLC-Q-orbitrap-MS identification. Phytochemical analysis : PCA. 2023 Sep; ?(?):. doi: 10.1002/pca.3284. [PMID: 37735858]
  • Jiali Yang, Lifeng Zhang, Xiaojuan Peng, Shuai Zhang, Shuwen Sun, Qiteng Ding, Chuanbo Ding, Wencong Liu. Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3. Molecules (Basel, Switzerland). 2023 Jun; 28(13):. doi: 10.3390/molecules28135066. [PMID: 37446725]
  • Song Gao, Cancan Fang, Tiancheng Wang, Wenjie Lu, Nan Wang, Lingfeng Sun, Wenyou Fang, Yang Chen, Rongfeng Hu. The effect of ginsenoside Rg3 combined with chemotherapy on immune function in non-small cell lung cancer: A systematic review and meta-analysis of randomized controlled trials. Medicine. 2023 Apr; 102(14):e33463. doi: 10.1097/md.0000000000033463. [PMID: 37026927]
  • Guangyuan Hu, Na Luo, Qiuyun Guo, Dingkun Wang, Ping Peng, Dongbo Liu, Shunfang Liu, Linli Zhang, Guoxian Long, Wei Sun. Ginsenoside Rg3 Sensitizes Nasopharyngeal Carcinoma Cells to Radiation by Suppressing Epithelial Mesenchymal Transition. Radiation research. 2023 Mar; ?(?):. doi: 10.1667/rade-22-00183.1. [PMID: 36946792]
  • Jie Xiong, Hongmei Yuan, Shihong Fei, Shengli Yang, Ming You, Li Liu. The preventive role of the red gingeng ginsenoside Rg3 in the treatment of lung tumorigenesis induced by benzo(a)pyrene. Scientific reports. 2023 Mar; 13(1):4528. doi: 10.1038/s41598-023-31710-9. [PMID: 36941308]
  • Shicheng Bi, Jianjian Shao, Yiwen Qu, Wei Xu, Jun Li, Li Zhang, Wanyu Shi, Liting Cao. Serum metabolomics reveal pathways associated with protective effect of ginsenoside Rg3 on immune stress. Poultry science. 2022 Dec; 101(12):102187. doi: 10.1016/j.psj.2022.102187. [PMID: 36215740]
  • Junwen Chen, Jinlian Chen, Zhanwen Wang, Chengchun Chen, Jinxin Zheng, Zhijian Yu, Qiwen Deng, Yuxi Zhao, Zewen Wen. 20S-ginsenoside Rg3 inhibits the biofilm formation and haemolytic activity of Staphylococcus aureus by inhibiting the SaeR/SaeS two-component system. Journal of medical microbiology. 2022 Oct; 71(10):. doi: 10.1099/jmm.0.001587. [PMID: 36288093]
  • Jiaxuan Xia, Shuya Zhang, Ru Zhang, Anni Wang, Ying Zhu, Meichen Dong, Shaojie Ma, Chao Hong, Shengyao Liu, Dan Wang, Jianxin Wang. Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes. Journal of nanobiotechnology. 2022 Sep; 20(1):414. doi: 10.1186/s12951-022-01623-2. [PMID: 36109762]
  • Lu Yao, Huanyu Zhang, Yirong Liu, Qiushuang Ji, Jing Xie, Ru Zhang, Luqi Huang, Kunrong Mei, Juan Wang, Wenyuan Gao. Engineering of triterpene metabolism and overexpression of the lignin biosynthesis gene PAL promotes ginsenoside Rg3 accumulation in ginseng plant chassis. Journal of integrative plant biology. 2022 Sep; 64(9):1739-1754. doi: 10.1111/jipb.13315. [PMID: 35731022]
  • Qiong Lai, Fu-Ming Liu, Wang-Lin Rao, Guang-Ying Yuan, Zhao-Yang Fan, Lu Zhang, Fei Fu, Jun-Ping Kou, Bo-Yang Yu, Fang Li. Aminoacylase-1 plays a key role in myocardial fibrosis and the therapeutic effects of 20(S)-ginsenoside Rg3 in mouse heart failure. Acta pharmacologica Sinica. 2022 Aug; 43(8):2003-2015. doi: 10.1038/s41401-021-00830-1. [PMID: 34916608]
  • Geyuan Qi, Baoyu Ji, Yanan Zhang, Luqi Huang, Juan Wang, Wenyuan Gao. Microbiome-based screening and co-fermentation of rhizospheric microorganisms for highly ginsenoside Rg3 production. Microbiological research. 2022 Aug; 261(?):127054. doi: 10.1016/j.micres.2022.127054. [PMID: 35598356]
  • Shangbin Lv, Xiaodong Chen, Yu Chen, Daoyin Gong, Gang Mao, Caifei Shen, Ting Xia, Jing Cheng, Zhaoliang Luo, Yu Cheng, Weihong Li, Jinhao Zeng. Ginsenoside Rg3 induces apoptosis and inhibits proliferation by down-regulating TIGAR in rats with gastric precancerous lesions. BMC complementary medicine and therapies. 2022 Jul; 22(1):188. doi: 10.1186/s12906-022-03669-z. [PMID: 35840932]
  • Jiaxuan Xia, Shaojie Ma, Xi Zhu, Chen Chen, Ru Zhang, Zhonglian Cao, Xing Chen, Longlong Zhang, Ying Zhu, Shuya Zhang, Shiyi Li, Guolong Gu, Xunbin Wei, Kunqian Yu, Jianxin Wang. Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches. Science advances. 2022 02; 8(6):eabj1262. doi: 10.1126/sciadv.abj1262. [PMID: 35148178]
  • Zhongzhen Zeng, Qing Nian, Nianzhi Chen, Maoyuan Zhao, Qiao Zheng, Gang Zhang, Ziyi Zhao, Yu Chen, Jundong Wang, Jinhao Zeng, Daoyin Gong, Jianyuan Tang. Ginsenoside Rg3 inhibits angiogenesis in gastric precancerous lesions through downregulation of Glut1 and Glut4. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jan; 145(?):112086. doi: 10.1016/j.biopha.2021.112086. [PMID: 34799220]
  • Tehasi Wang, Chengguang Zhang, Shuren Wang. Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner. Journal of orthopaedic surgery and research. 2021 Dec; 16(1):724. doi: 10.1186/s13018-021-02868-7. [PMID: 34930332]
  • Zhongjian Pu, Fei Ge, Yajun Wang, Ziyu Jiang, Shilin Zhu, Shukui Qin, Qijun Dai, Hua Liu, Haiqing Hua. Ginsenoside-Rg3 inhibits the proliferation and invasion of hepatoma carcinoma cells via regulating long non-coding RNA HOX antisense intergenic. Bioengineered. 2021 12; 12(1):2398-2409. doi: 10.1080/21655979.2021.1932211. [PMID: 34130594]
  • Jinghui Zhai, Huan Gao, Shuo Wang, Sixi Zhang, Xiaoyu Qu, Yueming Zhang, Lina Tao, Jingmeng Sun, Yanqing Song, Li Fu. Ginsenoside Rg3 attenuates cisplatin-induced kidney injury through inhibition of apoptosis and autophagy-inhibited NLRP3. Journal of biochemical and molecular toxicology. 2021 Nov; 35(11):e22896. doi: 10.1002/jbt.22896. [PMID: 34423507]
  • Zhihao Liu, Xiyun Bian, Wenbo Gao, Jing Su, Chuanrui Ma, Xiaolin Xiao, Tian Yu, Han Zhang, Xiaozhi Liu, Guanwei Fan. Rg3 promotes the SUMOylation of SERCA2a and corrects cardiac dysfunction in heart failure. Pharmacological research. 2021 10; 172(?):105843. doi: 10.1016/j.phrs.2021.105843. [PMID: 34428586]
  • Dingqi Zhang, Sami Hamdoun, Ruihong Chen, Lijun Yang, Chi Kio Ip, Yuanqing Qu, Runfeng Li, Haiming Jiang, Zifeng Yang, Sookja Kim Chung, Liang Liu, Vincent Kam Wai Wong. Identification of natural compounds as SARS-CoV-2 entry inhibitors by molecular docking-based virtual screening with bio-layer interferometry. Pharmacological research. 2021 10; 172(?):105820. doi: 10.1016/j.phrs.2021.105820. [PMID: 34403732]
  • Manying Wang, Rui Jiang, Jianzeng Liu, Xiaohao Xu, Guang Sun, Daqing Zhao, Liwei Sun. 20(s)‑ginseonside‑Rg3 modulation of AMPK/FoxO3 signaling to attenuate mitochondrial dysfunction in a dexamethasone‑injured C2C12 myotube‑based model of skeletal atrophy in vitro. Molecular medicine reports. 2021 05; 23(5):. doi: 10.3892/mmr.2021.11945. [PMID: 33649814]
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