Jujuboside B (BioDeep_00000000274)

 

Secondary id: BioDeep_00000396392, BioDeep_00000620005, BioDeep_00001867484

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


2-[(4-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl]oxy}-5-hydroxy-2-{[16-hydroxy-2,6,6,10,16-pentamethyl-18-(2-methylprop-1-en-1-yl)-19,21-dioxahexacyclo[18.2.1.0¹,¹⁴.0²,¹¹.0⁵,¹⁰.0¹⁵,²⁰]tricosan-7-yl]oxy}oxan-3-yl)oxy]-6-methyloxane-3,4,5-triol

化学式: C52H84O21 (1044.5505)
中文名称: 酸枣仁皂苷 B, 酸枣仁皂苷B1, 酸枣仁皂苷B, 酸枣仁皂苷 B1
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)=CC1CC(C)(O)C2C3CCC4C5(C)CCC(OC6OCC(O)C(OC7OC(CO)C(O)C(O)C7OC7OCC(O)C(O)C7O)C6OC6OC(C)C(O)C(O)C6O)C(C)(C)C5CCC4(C)C34COC2(C4)O1
InChI: InChI=1S/C52H84O21/c1-22(2)15-24-16-50(8,63)42-25-9-10-30-48(6)13-12-31(47(4,5)29(48)11-14-49(30,7)51(25)20-52(42,73-24)66-21-51)69-45-41(72-44-38(62)35(59)32(56)23(3)67-44)39(27(55)19-65-45)70-46-40(36(60)34(58)28(17-53)68-46)71-43-37(61)33(57)26(54)18-64-43/h15,23-46,53-63H,9-14,16-21H2,1-8H3

描述信息

Jujuboside B is a triterpenoid.
Jujuboside B is a natural product found in Ziziphus spina-christi, Ziziphus jujuba, and Hovenia dulcis with data available.
Jujuboside B1 is found in fruits. Jujuboside B1 is isolated from seeds of Zizyphus jujuba (Chinese date).
Isolated from seeds of Zizyphus jujuba (Chinese date). Jujuboside B1 is found in fruits.
Jujuboside B is one of the major bioactive constituents isolated from Zizyphus jujuba. Jujuboside B can inhibit platelet aggregation[1].
Jujuboside B is one of the major bioactive constituents isolated from Zizyphus jujuba. Jujuboside B can inhibit platelet aggregation[1].

同义名列表

5 个代谢物同义名

2-[(4-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl]oxy}-5-hydroxy-2-{[16-hydroxy-2,6,6,10,16-pentamethyl-18-(2-methylprop-1-en-1-yl)-19,21-dioxahexacyclo[18.2.1.0¹,¹⁴.0²,¹¹.0⁵,¹⁰.0¹⁵,²⁰]tricosan-7-yl]oxy}oxan-3-yl)oxy]-6-methyloxane-3,4,5-triol; Jujuboside B, >=98\\% (HPLC); Jujuboside B1; Jujuboside B; Jujuboside



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 BCL2, CASP3, CYP2E1, HMGB1, MLKL, MTOR, MYD88, NOS3, NR3C1, PIK3CA, PRKAA2, SLC22A5, TLR2
Peripheral membrane protein 3 CYP2E1, HMGB1, MTOR
Endosome membrane 1 MYD88
Endoplasmic reticulum membrane 5 BCL2, CYP2E1, GRIA1, HMOX1, MTOR
Nucleus 12 BCL2, CASP3, GABPA, HMGB1, HMOX1, KDR, MLKL, MTOR, MYD88, NOS3, NR3C1, PRKAA2
cytosol 12 BCL2, CASP3, GRIA1, HMOX1, MLKL, MTOR, MYD88, NOS3, NR3C1, PIK3CA, PRKAA2, SLC22A5
dendrite 4 GRIA1, GRIA2, MTOR, PRKAA2
phagocytic vesicle 1 MTOR
centrosome 1 NR3C1
nucleoplasm 8 CASP3, GABPA, HMGB1, HMOX1, MTOR, NOS3, NR3C1, PRKAA2
Cell membrane 7 GRIA1, GRIA2, HMGB1, KDR, MLKL, SLC22A5, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 1 PIK3CA
Early endosome membrane 1 GRIA1
Multi-pass membrane protein 3 GRIA1, GRIA2, SLC22A5
Golgi apparatus membrane 1 MTOR
Synapse 2 GRIA1, NR3C1
cell junction 2 KDR, MLKL
cell surface 5 GRIA1, HMGB1, MYD88, TLR2, TNF
dendritic shaft 1 GRIA1
glutamatergic synapse 2 CASP3, GRIA1
Golgi apparatus 4 KDR, NOS3, PRKAA2, TLR2
Golgi membrane 2 MTOR, NOS3
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 CYP2E1
neuromuscular junction 1 GRIA1
neuronal cell body 5 CASP3, GRIA1, GRIA2, PRKAA2, TNF
postsynapse 1 GRIA2
Lysosome 1 MTOR
Presynapse 1 GRIA1
endosome 2 HMGB1, KDR
plasma membrane 11 GRIA1, GRIA2, HMGB1, KDR, MLKL, MYD88, NOS3, PIK3CA, SLC22A5, TLR2, TNF
synaptic vesicle membrane 1 GRIA1
Membrane 9 BCL2, GRIA1, GRIA2, HMOX1, MTOR, NR3C1, PRKAA2, SLC22A5, TLR2
apical plasma membrane 1 SLC22A5
axon 1 PRKAA2
caveola 1 NOS3
extracellular exosome 1 SLC22A5
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 BCL2, HMGB1, HMOX1, KDR, SLC22A5
extracellular space 4 HMGB1, HMOX1, IL4, TNF
perinuclear region of cytoplasm 3 HMOX1, NOS3, PIK3CA
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, NR3C1
protein-containing complex 3 BCL2, MYD88, NR3C1
intracellular membrane-bounded organelle 1 CYP2E1
Microsome membrane 2 CYP2E1, MTOR
postsynaptic density 3 CASP3, GRIA1, GRIA2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR2
Secreted 2 HMGB1, IL4
extracellular region 4 HMGB1, IL4, KDR, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
excitatory synapse 2 GRIA1, GRIA2
neuronal cell body membrane 1 GRIA1
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 NR3C1
Extracellular side 1 HMGB1
anchoring junction 1 KDR
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 4 GRIA1, GRIA2, KDR, TNF
dendritic spine 2 GRIA1, GRIA2
neuron spine 1 GRIA1
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
Early endosome 1 KDR
cell-cell junction 1 GRIA1
recycling endosome 2 GRIA1, TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 2 GRIA1, GRIA2
presynaptic active zone membrane 1 GRIA1
Apical cell membrane 1 SLC22A5
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 3 KDR, TLR2, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 1 NR3C1
Cell projection, dendritic spine 1 GRIA1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
nuclear speck 2 NR3C1, PRKAA2
Postsynaptic cell membrane 2 GRIA1, GRIA2
receptor complex 2 KDR, TLR2
chromatin 2 GABPA, NR3C1
Cytoplasmic vesicle, phagosome membrane 1 TLR2
cell projection 1 TLR2
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 TLR2
Chromosome 2 HMGB1, NR3C1
cytoskeleton 1 NOS3
brush border membrane 1 SLC22A5
postsynaptic density, intracellular component 1 GRIA1
nuclear envelope 1 MTOR
Recycling endosome membrane 1 GRIA1
Endomembrane system 1 MTOR
sorting endosome 1 KDR
AMPA glutamate receptor complex 2 GRIA1, GRIA2
Nucleus, nucleoplasm 1 NR3C1
Cell projection, dendrite 1 GRIA1
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 2 NOS3, PRKAA2
cell body 1 TLR2
myelin sheath 1 BCL2
basal plasma membrane 1 SLC22A5
synaptic membrane 1 GRIA1
ficolin-1-rich granule lumen 1 HMGB1
secretory granule lumen 1 HMGB1
secretory granule membrane 1 TLR2
transcription repressor complex 1 HMGB1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle membrane 3 GRIA1, GRIA2, NOS3
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GRIA1
postsynaptic density membrane 2 GRIA1, GRIA2
postsynaptic endocytic zone 1 GRIA2
Single-pass type IV membrane protein 1 HMOX1
ER to Golgi transport vesicle membrane 1 GRIA1
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
Basal cell membrane 1 SLC22A5
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
condensed chromosome 1 HMGB1
Cytoplasmic vesicle, phagosome 1 MTOR
Toll-like receptor 1-Toll-like receptor 2 protein complex 1 TLR2
Toll-like receptor 2-Toll-like receptor 6 protein complex 1 TLR2
extrinsic component of plasma membrane 1 MYD88
dendritic spine membrane 1 GRIA1
[Isoform 3]: Endoplasmic reticulum 1 SLC22A5
[Isoform Alpha]: Cytoplasm 1 NR3C1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
asymmetric synapse 1 GRIA2
BAD-BCL-2 complex 1 BCL2
proximal dendrite 1 GRIA1
axonal spine 1 GRIA1
perisynaptic space 1 GRIA1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Wei Li, Yanqing Zhang, Jing Zhao, Tan Yang, Junbo Xie. L-carnitine modified nanoparticles target the OCTN2 transporter to improve the oral absorption of jujuboside B. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 Jan; ?(?):114185. doi: 10.1016/j.ejpb.2024.114185. [PMID: 38280469]
  • Jinrui Liu, Yanqing Zhang, Chang-Jiang-Sheng Lai, Junbo Xie. Multitarget Protective Effects of JUB on Aβ-Induced Neurotoxicity and the Mechanism Predication Using Network Pharmacology Analysis. Journal of agricultural and food chemistry. 2023 Dec; 71(51):20724-20734. doi: 10.1021/acs.jafc.3c06430. [PMID: 38098161]
  • Caijing Liu, Jing Li, Lidan Zhu, Linmin Lian, Luyi Jiang, Hanbing Li, Jizhong Yan, Chu Chu. A sensitive two-step stacking by coupling field-enhanced sample injection and micelle to cyclodextrin stacking for the determination of neutral analytes. Journal of chromatography. A. 2020 May; 1618(?):460854. doi: 10.1016/j.chroma.2020.460854. [PMID: 31980258]
  • Yan Chen, Enci Jiang, Jizhong Yan, Yi Tao. Validation of an analytical method using UPLC-MS/MS to quantify four bioactive components in rat plasma and its application to pharmacokinetic study of traditional and dispensing granules decoction of Ziziphi Spinosae Semen. Biomedical chromatography : BMC. 2020 Apr; 34(4):e4797. doi: 10.1002/bmc.4797. [PMID: 31989669]
  • Muhammad Noman Khan, Faraz Ul Haq, Saeedur Rahman, Arslan Ali, Syed Ghulam Musharraf. Metabolite distribution and correlation studies of Ziziphus jujuba and Ziziphus nummularia using LC-ESI-MS/MS. Journal of pharmaceutical and biomedical analysis. 2020 Jan; 178(?):112918. doi: 10.1016/j.jpba.2019.112918. [PMID: 31629227]
  • Chuan-Qin Wu, Guan-Hua Chen. Detection of synergistic effect of superoxide dismutase and jujubosides on scavenging superoxide anion radical by capillary electrophoresis. Biomedical chromatography : BMC. 2019 Oct; 33(10):e4630. doi: 10.1002/bmc.4630. [PMID: 31243785]
  • Prafull Bandopant Ninave, Savita Dattatray Patil. Antiasthmatic potential of Zizyphus jujuba Mill and Jujuboside B. - Possible role in the treatment of asthma. Respiratory physiology & neurobiology. 2019 02; 260(?):28-36. doi: 10.1016/j.resp.2018.12.001. [PMID: 30521862]
  • Yan Yan, Qiang Li, Chen-hui Du, Jin-ping Jia, Hong-xia Feng, Xue-mei Qin. [Investigation of the potentially effective components of Semen Ziziphi Spinosae based on “in vitro to in vivo” translation approach]. Yao xue xue bao = Acta pharmaceutica Sinica. 2017 Feb; 52(2):283-90. doi: NULL. [PMID: 29979520]
  • Yanqing Zhang, Yan Zhang, Kunsheng Zhang, Guijie Ma, Mingchun Zhang, Junbo Xie. Degradation kinetics of jujuboside b by rat intestinal flora in vitro with an RRLC-MS-MS method. Journal of chromatographic science. 2014 Aug; 52(7):691-6. doi: 10.1093/chromsci/bmt100. [PMID: 23828910]
  • Eun Ji Seo, So Young Lee, Sam Sik Kang, Yi-Sook Jung. Zizyphus jujuba and its active component jujuboside B inhibit platelet aggregation. Phytotherapy research : PTR. 2013 Jun; 27(6):829-34. doi: 10.1002/ptr.4809. [PMID: 22893618]
  • Mingchun Zhang, Yanqing Zhang, Junbo Xie. Simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae by high performance liquid chromatography-evaporative light scattering detection. Journal of pharmaceutical and biomedical analysis. 2008 Dec; 48(5):1467-70. doi: 10.1016/j.jpba.2008.09.022. [PMID: 18977107]