Patuletin (BioDeep_00000270609)

PANOMIX_OTCML-2023

代谢物信息卡片

2- (3,4-Dihydroxyphenyl) -3,5,7-trihydroxy-6-methoxy-4H-1-benzopyran-4-one

化学式: C16H12O8 (332.0532152)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(c(c(c2c(c1)oc(c(c2=O)O)c1ccc(c(c1)O)O)O)OC)O
InChI: InChI=1S/C16H12O8/c1-23-16-9(19)5-10-11(13(16)21)12(20)14(22)15(24-10)6-2-3-7(17)8(18)4-6/h2-5,17-19,21-22H,1H3

描述信息

A trimethoxyflavone that is quercetagetin methylated at position 6.
D004791 - Enzyme Inhibitors

同义名列表

14 个代谢物同义名

2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4H-1-benzopyran-4-one; 3,5,7,3,4-Pentahydroxy-6-methoxyflavone; Quercetagetin 6-methyl ether; 6-Methoxyquercetin; Patuletin; 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-benzopyrone; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxychromen-4-one; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-4-chromenone; 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-6-methoxy-chromone; EINECS 208-280-8; 519-96-0; C10118; 2- (3,4-Dihydroxyphenyl) -3,5,7-trihydroxy-6-methoxy-4H-1-benzopyran-4-one

数据库引用编号

13 个数据库交叉引用编号

ChEBI: CHEBI:75164
KEGG: C10118
PubChem: 5281678
ChEMBL: CHEMBL465155
LipidMAPS: LMPK12112986
KNApSAcK: C00004680
CAS: 519-96-0
Flavonoid: FL5FECNS0005
MetaboLights: MTBLC75164
PubChem: 12304
3DMET: B03556
NIKKAJI: J11.683A
RefMet: Patuletin

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

67 个相关的物种来源信息

282739 - Achillea grandifolia: 10.1016/0305-1978(88)90033-6
352482 - Actinocephalus polyanthus: 10.1016/S0031-9422(99)00028-X
2773062 - Ageratina areolaris: 10.1021/NP50043A039
2773069 - Ageratina havanensis: 10.1021/NP50048A063
2773124 - Ageratina saltillensis: 10.1021/NP50048A063
158220 - Anthemis cotula: 10.1016/S0367-326X(00)00229-X
563858 - Arctotis argentea: 10.1016/S0305-1978(97)00007-0
41478 - Arctotis stoechadifolia: 10.1016/S0305-1978(97)00007-0
436459 - Arnica acaulis: 10.1016/0031-9422(88)83030-9
436195 - Arnica chamissonis: 10.2298/HEMIND0704272R
436198 - Arnica gracilis: 10.1002/J.1537-2197.1987.TB12148.X
436203 - Arnica latifolia:
436207 - Arnica montana: 10.2298/HEMIND0704272R
436212 - Arnica sachalinensis: 10.1016/0305-1978(90)90026-C
35608 - Artemisia annua:
72335 - Artemisia barrelieri: 10.1016/S0305-1978(02)00178-3
72329 - Artemisia herba-alba: 10.1016/S0031-9422(00)80845-6
72348 - Artemisia monosperma: 10.1016/S0031-9422(00)80845-6
4210 - Asteraceae:
230209 - Balsamorhiza sagittata: 10.1016/0305-1978(88)90034-8
86860 - Boopis graminea: 10.1139/B95-209
1550813 - Brickellia cylindracea: 10.1016/0305-1978(83)90027-3
516719 - Calycera crassifolia: 10.1139/B95-209
2557549 - Calycera eryngioides: 10.1139/B95-209
1892786 - Calycera herbacea: 10.1139/B95-209
1892788 - Calycera leucanthema: 10.1139/B95-209
1892791 - Calycera sympaganthera: 10.1139/B95-209
145490 - Centaurea collina: 10.1016/S0305-1978(97)00007-0
48106 - Centella asiatica: 10.3987/COM-01-9259
2894882 - Centromadia fitchii: 10.1016/0305-1978(87)90101-3
1458965 - Chiliadenus montanus: 10.1016/0031-9422(89)80084-6
425860 - Deinandra arida: 10.1016/0305-1978(87)90101-3
425864 - Deinandra corymbosa: 10.1016/0305-1978(87)90101-3
149420 - Deinandra fasciculata:
425867 - Deinandra greeneana: 10.1016/0305-1978(87)90101-3
425868 - Deinandra halliana: 10.1016/0305-1978(87)90101-3
425870 - Deinandra kelloggii: 10.1016/0305-1978(87)90101-3
170371 - Deinandra lobbii:
425872 - Deinandra minthornii: 10.1016/0305-1978(87)90101-3
425874 - Deinandra pallida: 10.1016/0305-1978(87)90101-3
425876 - Deinandra paniculata: 10.1016/0305-1978(87)90101-3
425877 - Deinandra pentactis:
425878 - Deinandra streetsii: 10.1016/0305-1978(87)90101-3
1387318 - Eriocaulon buergerianum: 10.1016/J.PHYTOCHEM.2007.11.014
584531 - Eriocaulon cinereum: 10.1016/J.JPBA.2011.08.033
102777 - Eupatorium perfoliatum: 10.1016/J.PHYTOCHEM.2011.01.025
1573924 - Gutierrezia wrightii: 10.1021/NP50046A053
40742 - Ipomopsis aggregata: 10.1016/S0031-9422(00)97361-8
1435564 - Kalanchoe laciniata: 10.1016/S0031-9422(00)98096-8
493314 - Loeseliastrum depressum: 10.1016/0305-1978(85)90072-9
1227330 - Microliabum polymnioides: 10.1016/0305-1978(94)00093-V
1892802 - Nastanthus scapigerus: 10.1139/B95-209
516709 - Nastanthus spathulatus: 10.1139/B95-209
73981 - Pallenis spinosa: 10.1016/0305-1978(92)90038-F
119176 - Pentanema britannicum:
364024 - Prosopis cineraria: 10.1021/NP50018A003
1217432 - Prosopis spicigera: 10.1021/NP50018A003
362630 - Rhaponticum carthamoides: 10.1016/J.PHYTOCHEM.2009.04.008
13708 - Tagetes erecta:
169606 - Tagetes lucida: 10.1021/JF053071W
169607 - Tagetes minuta:
55843 - Tagetes patula:
1000433 - Verbascum lychnitis: 10.1007/BF00564831
33090 - 旋覆花: -
33090 - 谷精草: -
33090 - 金沸草: -
496566 - 青蒿: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Dinesh Kumar Patel, Gireesh Kumar Singh, Gulam Mohammed Husain, Satyendra K Prasad. Ethnomedicinal importance of Patuletin in Medicine: Pharmacological Activities and Analytical Aspects. Endocrine, metabolic & immune disorders drug targets. 2023 Aug; ?(?):. doi: 10.2174/1871530323666230816141740. [PMID: 37584350]
G N Voitenko, A A Kalashnikov, N V Kurdil, V L Savytskyi, L A Ustinova, O G Lutsenko. PROSPECTS FOR CREATION OF RADIOPROTECTIVE MEANS BASED ON NATURAL POLYPHENOLS AND POLYSACCHARIDES. Problemy radiatsiinoi medytsyny ta radiobiolohii. 2020 Dec; 25(?):309-320. doi: 10.33145/2304-8336-2020-25-309-320. [PMID: 33361843]
Jovana Stanković, Dejan Gođevac, Vele Tešević, Zora Dajić-Stevanović, Ana Ćirić, Marina Soković, Miroslav Novaković. Antibacterial and Antibiofilm Activity of Flavonoid and Saponin Derivatives from Atriplex tatarica against Pseudomonas aeruginosa. Journal of natural products. 2019 06; 82(6):1487-1495. doi: 10.1021/acs.jnatprod.8b00970. [PMID: 31181926]
Mohammad Zarei, Saeed Mohammadi, Alireza Komaki. Antinociceptive activity of Inula britannica L. and patuletin: In vivo and possible mechanisms studies. Journal of ethnopharmacology. 2018 Jun; 219(?):351-358. doi: 10.1016/j.jep.2018.03.021. [PMID: 29567278]
Zlatina Kokanova-Nedialkova, Paraskev Nedialkov, Magdalena Kondeva-Burdina, Rumyana Simeonova, Virginia Tzankova, Denitsa Aluani. Chenopodium bonus-henricus L. - A source of hepatoprotective flavonoids. Fitoterapia. 2017 Apr; 118(?):13-20. doi: 10.1016/j.fitote.2017.02.001. [PMID: 28229939]
Jane Hubert, Sébastien Chollet, Sylvain Purson, Romain Reynaud, Dominique Harakat, Agathe Martinez, Jean-Marc Nuzillard, Jean-Hugues Renault. Exploiting the Complementarity between Dereplication and Computer-Assisted Structure Elucidation for the Chemical Profiling of Natural Cosmetic Ingredients: Tephrosia purpurea as a Case Study. Journal of natural products. 2015 Jul; 78(7):1609-17. doi: 10.1021/acs.jnatprod.5b00174. [PMID: 26103208]
Muhammad Ateeq, Muhammad Raza Shah, Noor Ul Ain, Samina Bano, Itrat Anis, Lubna, Shaheen Faizi, Massimo F Bertino, Syeda Sohaila Naz. Green synthesis and molecular recognition ability of patuletin coated gold nanoparticles. Biosensors & bioelectronics. 2015 Jan; 63(?):499-505. doi: 10.1016/j.bios.2014.07.076. [PMID: 25129513]
Ilkay Erdogan Orhan. Centella asiatica (L.) Urban: From Traditional Medicine to Modern Medicine with Neuroprotective Potential. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):946259. doi: 10.1155/2012/946259. [PMID: 22666298]
Souheila Louaar, Amel Achouri, Mostefa Lefahal, Hocine Laouer, Kamel Medjroubi, Helmut Duddeck, Salah Akkal. Flavonoids from Algerian endemic Centaurea microcarpa and their chemotaxonomical significance. Natural product communications. 2011 Nov; 6(11):1603-4. doi: . [PMID: 22224272]
Shaheen Faizi, Shahina Fayyaz, Samina Bano, Erum Yawar Iqbal, Lubna, Humaira Siddiqi, Aneela Naz. Isolation of nematicidal compounds from Tagetes patula L. yellow flowers: structure-activity relationship studies against cyst nematode Heterodera zeae infective stage larvae. Journal of agricultural and food chemistry. 2011 Sep; 59(17):9080-93. doi: 10.1021/jf201611b. [PMID: 21780738]
Yun Wei, Qianqian Xie, Derek Fisher, Ian A Sutherland. Separation of patuletin-3-O-glucoside, astragalin, quercetin, kaempferol and isorhamnetin from Flaveria bidentis (L.) Kuntze by elution-pump-out high-performance counter-current chromatography. Journal of chromatography. A. 2011 Sep; 1218(36):6206-11. doi: 10.1016/j.chroma.2011.01.058. [PMID: 21329934]
Giuseppina Negri, Erica Weinstein Teixeira, Maria Luisa Teles Marques Florêncio Alves, Augusta Carolina de Camargo Carmello Moreti, Ivani Pozar Otsuk, Renata Galhardo Borguini, Antonio Salatino. Hydroxycinnamic acid amide derivatives, phenolic compounds and antioxidant activities of extracts of pollen samples from Southeast Brazil. Journal of agricultural and food chemistry. 2011 May; 59(10):5516-22. doi: 10.1021/jf200602k. [PMID: 21500799]
Shaheen Faizi, Ahsana Dar, Humaira Siddiqi, Sabira Naqvi, Aneela Naz, Samina Bano, Lubna. Bioassay-guided isolation of antioxidant agents with analgesic properties from flowers of Tagetes patula. Pharmaceutical biology. 2011 May; 49(5):516-25. doi: 10.3109/13880209.2010.523006. [PMID: 21284510]
Tan Jackie, Nagaraja Haleagrahara, Srikumar Chakravarthi. Antioxidant effects of Etlingera elatior flower extract against lead acetate - induced perturbations in free radical scavenging enzymes and lipid peroxidation in rats. BMC research notes. 2011 Mar; 4(?):67. doi: 10.1186/1756-0500-4-67. [PMID: 21414212]
Ompal Singh, Zakia Khanam, Neelam Misra, Manoj Kumar Srivastava. Chamomile (Matricaria chamomilla L.): An overview. Pharmacognosy reviews. 2011 Jan; 5(9):82-95. doi: 10.4103/0973-7847.79103. [PMID: 22096322]
Bailian Liu, Ting Zhang, Xiaoqi Zhang, Wencai Ye, Yaolan Li. [Chemical constituents of Laggera pterodonta]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Mar; 35(5):602-6. doi: 10.4268/cjcmm20100513. [PMID: 20506820]
Petr Stodulka, Vit Koleckar, Daniel Jun, Kamil Kuca, Zuzana Rehakova, Katerina Kubikova, Ludek Jahodar, Jiri Kunes, Lubomir Opletal. High-performance liquid chromatography analysis of four Leuzea carthamoides flavonoids. Journal of chromatographic science. 2008 Feb; 46(2):162-4. doi: 10.1093/chromsci/46.2.162. [PMID: 18366877]
Vit Koleckar, Eliska Brojerova, Zuzana Rehakova, Katerina Kubikova, Frantisek Cervenka, Kamil Kuca, Daniel Jun, Miloslav Hronek, Veronika Opletalova, Lubomir Opletal. In vitro antiplatelet activity of flavonoids from Leuzea carthamoides. Drug and chemical toxicology. 2008; 31(1):27-35. doi: 10.1080/01480540701688444. [PMID: 18161506]
Diane L McKay, Jeffrey B Blumberg. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytotherapy research : PTR. 2006 Jul; 20(7):519-30. doi: 10.1002/ptr.1900. [PMID: 16628544]
Carlos L Céspedes, J Guillermo Avila, Andrés Martínez, Blanca Serrato, José C Calderón-Mugica, Rafael Salgado-Garciglia. Antifungal and antibacterial activities of Mexican tarragon (Tagetes lucida). Journal of agricultural and food chemistry. 2006 May; 54(10):3521-7. doi: 10.1021/jf053071w. [PMID: 19127719]
I Masterová, D Grancai, Z Grancaiová, M Pour, K Ubik. A new flavonoid: tinctosid from Anthemis tinctoria L. Die Pharmazie. 2005 Dec; 60(12):956-7. doi: ". [PMID: 16398276]
N Pandjaitan, L R Howard, T Morelock, M I Gil. Antioxidant capacity and phenolic content of spinach as affected by genetics and maturation. Journal of agricultural and food chemistry. 2005 Nov; 53(22):8618-23. doi: 10.1021/jf052077i. [PMID: 16248562]
Guillermo Schmeda-Hirschmann, Alejandro Tapia, Cristina Theoduloz, Jaime Rodríguez, Susana López, Gabriela Egly Feresin. Free radical scavengers and antioxidants from Tagetes mendocina. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2004 May; 59(5-6):345-53. doi: 10.1515/znc-2004-5-610. [PMID: 18998399]
Christine A Williams, Jeffrey B Harborne, Jenny R Greenham, Renée J Grayer, Geoffrey C Kite, John Eagles. Variations in lipophilic and vacuolar flavonoids among European Pulicaria species. Phytochemistry. 2003 Sep; 64(1):275-83. doi: 10.1016/s0031-9422(03)00207-3. [PMID: 12946426]
So Ra Kim, Mi Jung Park, Mi Kyeong Lee, Sang Hyun Sung, Eun Jung Park, Jinwoong Kim, Sun Yeou Kim, Tae H Oh, George J Markelonis, Young Choong Kim. Flavonoids of Inula britannica protect cultured cortical cells from necrotic cell death induced by glutamate. Free radical biology & medicine. 2002 Apr; 32(7):596-604. doi: 10.1016/s0891-5849(02)00751-7. [PMID: 11909694]
S S Costa, A Jossang, B Bodo, M L Souza, V L Moraes. Patuletin acetylrhamnosides from Kalanchoe brasiliensis as inhibitors of human lymphocyte proliferative activity. Journal of natural products. 1994 Nov; 57(11):1503-10. doi: 10.1021/np50113a005. [PMID: 7853000]
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