Sulindac (BioDeep_00000002700)

 

Secondary id: BioDeep_00000408955

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid

化学式: C20H17FO3S (356.0882384)
中文名称: 舒林酸
谱图信息: 最多检出来源 Homo sapiens(blood) 2.78%

分子结构信息

SMILES: CC1=C(C2=C(C1=CC3=CC=C(C=C3)S(=O)C)C=CC(=C2)F)CC(=O)O
InChI: InChI=1S/C20H17FO3S/c1-12-17(9-13-3-6-15(7-4-13)25(2)24)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-

描述信息

Sulindac is a nonsteroidal anti-inflammatory agent (NSAIA) of the arylalkanoic acid class that is marketed in the U.S. by Merck as Clinoril. Like other NSAIAs, it may be used in the treatment of acute or chronic inflammatory conditions. Sulindac is a prodrug, derived from sulfinylindene, that is converted in vivo to an active sulfide compound by liver enzymes. The sulfide metabolite then undergoes enterohepatic circulation; it is excreted in the bile and then reabsorbed from the intestine. This is thought to help maintain constant blood levels with reduced gastrointestinal side effects. Some studies have shown sulindac to be relatively less irritating to the stomach than other NSAIAs except for drugs of the cyclooxygenase-2 (COX-2) inhibitor class. The exact mechanism of its NSAIA properties is unknown, but it is thought to act on enzymes COX-1 and COX-2, inhibiting prostaglandin synthesis.
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AB - Acetic acid derivatives and related substances
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
C471 - Enzyme Inhibitor > C744 - Phosphodiesterase Inhibitor > C2127 - cGMP Phosphodiesterase Inhibitor
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D000970 - Antineoplastic Agents
KEIO_ID S054; [MS2] KO009077
KEIO_ID S054; [MS3] KO009079
D004791 - Enzyme Inhibitors
KEIO_ID S054

同义名列表

44 个代谢物同义名

2-[(1Z)-5-fluoro-1-[(4-methanesulfinylphenyl)methylidene]-2-methyl-1H-inden-3-yl]acetic acid; (Z)-5-Fluoro-2-methyl-1-((p-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetate; 2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]-1-indenyl]acetic acid; (Z)-5-Fluoro-2-methyl-1-((p-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetate; 5-fluoro-2-methyl-1Z-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetate; (Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetate; cis-5-Fluoro-2-methyl-1-((p-methylsulphinyl)benzylidene)indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid; cis-5-Fluoro-2-methyl-1-((p-methylsulphinyl)benzylidene)indene-3-acetate; cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetate; Merck sharp and dohme brand OF sulindac; Cahill may roberts brand OF sulindac; Alphapharm brand OF sulindac; Novopharm brand OF sulindac; Nu-pharm brand OF sulindac; Nu pharm brand OF sulindac; Kendrick brand OF sulindac; Apotex brand OF sulindac; Chemia brand OF sulindac; Merck brand OF sulindac; Novo sundac; Novo-sundac; Nu sulindac; Nu-sulindac; Sulindacum; Arthrocine; Apo sulin; Apo-sulin; Sulindaco; Arthrobid; Sulindal; Klinoril; Clinoril; Sulindac; Chibret; Kenalin; Copal; Aclin; Sulindac



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shufa Tan, Yan Ou, Yunyi Yang, Shuilan Huang, Shikai Chen, Qiangqiang Gao. Preventive effects of chemical drugs on recurrence of colorectal adenomas: systematic review and Bayesian network meta-analysis. European journal of gastroenterology & hepatology. 2023 Nov; ?(?):. doi: 10.1097/meg.0000000000002676. [PMID: 37942763]
  • Rosa María García-Núñez, Julio César Buendía-Espinoza, Selene Del Carmen Arrazate-Jiménez, Elisa Del Carmen Martínez-Ochoa. Effects of copal resin extraction on the diversity and composition of species in tropical deciduous forests. Scientific reports. 2023 03; 13(1):4199. doi: 10.1038/s41598-023-31423-z. [PMID: 36918726]
  • David Peris, Jörg U Hammel, Chenyang Cai, Mónica M Solórzano-Kraemer. First record of Jacobsoniidae (Coleoptera) on the African continent in Holocene copal from Tanzania: biogeography since the Cretaceous. Scientific reports. 2023 03; 13(1):3735. doi: 10.1038/s41598-023-30368-7. [PMID: 36878923]
  • Yanchao Xing, Qiao Yu, Lin Zhou, Wen Cai, Yuxin Zhang, Yajuan Bi, Youcai Zhang, Zhifei Fu, Lifeng Han. Cytochrome P450-mediated herb-drug interaction (HDI) of Polygonum multiflorum Thunb. based on pharmacokinetic studies and in vitro inhibition assays. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Feb; 112(?):154710. doi: 10.1016/j.phymed.2023.154710. [PMID: 36805481]
  • Yessica Rico, Gustavo P Lorenzana, Carlos A Benítez-Pineda, Bode A Olukolu. Development of Genomic Resources in Mexican Bursera (Section: Bullockia: Burseraceae): Genome Assembly, Annotation, and Marker Discovery for Three Copal Species. Genes. 2022 Sep; 13(10):. doi: 10.3390/genes13101741. [PMID: 36292626]
  • Suhail Razak, Tayyaba Afsar, Nousheen Bibi, Mahmoud Abulmeaty, Mashooq Ahmad Bhat, Anam Inam, Janeen H Trembley, Ali Almajwal, Maria Shabbir, Nawaf W Alruwaili, Abdulrahman Algarni. Sulindac acetohydrazide derivative attenuates against cisplatin induced organ damage by modulation of antioxidant and inflammatory signaling pathways. Scientific reports. 2022 07; 12(1):11749. doi: 10.1038/s41598-022-15950-9. [PMID: 35817806]
  • Charles M Bowen, Lewins Walter, Ester Borras, Wenhui Wu, Zuhal Ozcan, Kyle Chang, Prashant V Bommi, Melissa W Taggart, Selvi Thirumurthi, Patrick M Lynch, Laura Reyes-Uribe, Paul A Scheet, Krishna M Sinha, Eduardo Vilar. Combination of Sulindac and Bexarotene for Prevention of Intestinal Carcinogenesis in Familial Adenomatous Polyposis. Cancer prevention research (Philadelphia, Pa.). 2021 09; 14(9):851-862. doi: 10.1158/1940-6207.capr-20-0496. [PMID: 34266857]
  • Hua Li, Xiaofan Li, Boyu Yang, Junnan Su, Shaofang Cai, Jinmei Huang, Tianfu Hu, Lijuan Chen, Yaping Xu, Yuhang Li. The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis. Scientific reports. 2021 08; 11(1):16956. doi: 10.1038/s41598-021-96517-y. [PMID: 34417523]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Julien Allard, Simon Bucher, Julie Massart, Pierre-Jean Ferron, Dounia Le Guillou, Roxane Loyant, Yoann Daniel, Youenn Launay, Nelly Buron, Karima Begriche, Annie Borgne-Sanchez, Bernard Fromenty. Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell biology and toxicology. 2021 04; 37(2):151-175. doi: 10.1007/s10565-020-09537-1. [PMID: 32535746]
  • Glenn Lemmens, Joachim Brouwers, Jan Snoeys, Patrick Augustijns, Tim Vanuytsel. Insight into the Colonic Disposition of Sulindac in Humans. Journal of pharmaceutical sciences. 2021 01; 110(1):259-267. doi: 10.1016/j.xphs.2020.09.034. [PMID: 33002468]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Qing Long, Liang Ao, Kuo Li, Yan Li. The efficacy and safety of sulindac for colorectal polyps: A protocol for systematic review and meta-analysis. Medicine. 2020 Oct; 99(41):e22402. doi: 10.1097/md.0000000000022402. [PMID: 33031275]
  • Si Sheng, Xiaoying Yin, Fangmei Chen, Yixin Lv, Lin Zhang, Menghui Cao, Yun Sun. Preparation and Characterization of PVA-Co-PE Drug-Loaded Nanofiber Membrane by Electrospinning Technology. AAPS PharmSciTech. 2020 Jul; 21(5):199. doi: 10.1208/s12249-020-01715-y. [PMID: 32676796]
  • Gergő Dargó, Dávid Bajusz, Kristóf Simon, Judit Müller, György T Balogh. Human Serum Albumin Binding in a Vial: A Novel UV-pH Titration Method To Assist Drug Design. Journal of medicinal chemistry. 2020 02; 63(4):1763-1774. doi: 10.1021/acs.jmedchem.0c00046. [PMID: 31995375]
  • Jin Won Sung, Hwi-Yeol Yun, Sunny Park, Young Ju Kim, Jeong Yee, Kyung Eun Lee, Byungjeong Song, Jee Eun Chung, Hye Sun Gwak. Population Pharmacokinetics of Sulindac and Genetic Polymorphisms of FMO3 and AOX1 in Women with Preterm Labor. Pharmaceutical research. 2020 Jan; 37(3):44. doi: 10.1007/s11095-020-2765-6. [PMID: 31993760]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Linghong Shen, Zhe Sun, Peng Nie, Ruosen Yuan, Zhaohua Cai, Caizhe Wu, Liuhua Hu, Shuxuan Jin, Hu Zhou, Xiaokun Zhang, Ben He. Sulindac-derived retinoid X receptor-α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE-/- mice. British journal of pharmacology. 2019 07; 176(14):2559-2572. doi: 10.1111/bph.14682. [PMID: 30943581]
  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
  • Min Zhang, Manakan B Srichai, Min Zhao, Jian Chen, Linda S Davis, Guanqing Wu, Matthew D Breyer, Chuan-Ming Hao. Nonselective Cyclooxygenase Inhibition Retards Cyst Progression in a Murine Model of Autosomal Dominant Polycystic Kidney Disease. International journal of medical sciences. 2019; 16(1):180-188. doi: 10.7150/ijms.27719. [PMID: 30662341]
  • Seyedeh Atekeh Torabizadeh, Mehdi Rezaeifar, Ali Jomehzadeh, Farzaneh Nabizadeh Haghighi, Mehdi Ansari. Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation. Drug design, development and therapy. 2019; 13(?):4127-4134. doi: 10.2147/dddt.s218022. [PMID: 31827319]
  • Nahed M A Hassanein, Eman S G Hassan, Amany M Hegab, Helmy M Sayd Elahl. Chemopreventive effect of sulindac in combination with epigallocatechin gallate or kaempferol against 1,2-dimethyl hydrazine-induced preneoplastic lesions in rats: A Comparative Study. Journal of biochemical and molecular toxicology. 2018 Oct; 32(10):e22198. doi: 10.1002/jbt.22198. [PMID: 29999212]
  • Kiran Saba, Anser Maxood, Saeeda Abdullah, Amna Riaz, Shahab Ud Din. Comparison Of Frequency Of Post Operative Sensitivity In Amalgam Restorations Using Copal Varnish And Dentin Adhesive Liner. Journal of Ayub Medical College, Abbottabad : JAMC. 2018 Apr; 30(2):163-166. doi: ". [PMID: 29938411]
  • Barbara J Bałan, Andrzej K Siwicki, Krzysztof Pastewka, Urszula Demkow, Piotr Skopiński, Ewa Skopińska-Różewska, Sławomir Lewicki, Robert Zdanowski. Synergistic Activity for Natural and Synthetic Inhibitors of Angiogenesis Induced by Murine Sarcoma L-1 and Human Kidney Cancer Cells. Advances in experimental medicine and biology. 2017 ; 1020(?):91-104. doi: 10.1007/5584_2017_17. [PMID: 28456932]
  • Yong-Jun Tang, Kai Hu, Wei-Hua Huang, Chong-Zhi Wang, Zhi Liu, Yao Chen, Dong-Sheng Ouyang, Zhi-Rong Tan, Hong-Hao Zhou, Chun-Su Yuan. Effects of FMO3 Polymorphisms on Pharmacokinetics of Sulindac in Chinese Healthy Male Volunteers. BioMed research international. 2017; 2017(?):4189678. doi: 10.1155/2017/4189678. [PMID: 28331852]
  • Giulia Gigliarelli, Judith X Becerra, Massimo Curini, Maria Carla Marcotullio. Chemical Composition and Biological Activities of Fragrant Mexican Copal (Bursera spp.). Molecules (Basel, Switzerland). 2015 Dec; 20(12):22383-94. doi: 10.3390/molecules201219849. [PMID: 26703535]
  • Khosrow Kashfi, Mitali Chattopadhyay, Ravinder Kodela. NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory, analgesic, antipyretic, anti-platelet, and anti-cancer properties. Redox biology. 2015 Dec; 6(?):287-296. doi: 10.1016/j.redox.2015.08.012. [PMID: 26298203]
  • Venkata Charepalli, Lavanya Reddivari, Sridhar Radhakrishnan, Ramakrishna Vadde, Rajesh Agarwal, Jairam K P Vanamala. Anthocyanin-containing purple-fleshed potatoes suppress colon tumorigenesis via elimination of colon cancer stem cells. The Journal of nutritional biochemistry. 2015 Dec; 26(12):1641-9. doi: 10.1016/j.jnutbio.2015.08.005. [PMID: 26383537]
  • Chi C Wong, Ka-Wing Cheng, Ioannis Papayannis, George Mattheolabakis, Liqun Huang, Gang Xie, Nengtai Ouyang, Basil Rigas. Phospho-NSAIDs have enhanced efficacy in mice lacking plasma carboxylesterase: implications for their clinical pharmacology. Pharmaceutical research. 2015 May; 32(5):1663-75. doi: 10.1007/s11095-014-1565-2. [PMID: 25392229]
  • Marta M Wells, Tommy S Tillman, David D Mowrey, Tianmo Sun, Yan Xu, Pei Tang. Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain. Journal of medicinal chemistry. 2015 Apr; 58(7):2958-2966. doi: 10.1021/jm501873p. [PMID: 25790278]
  • H Sar Sancakli, R S Austin, F Al-Saqabi, R Moazzez, D Bartlett. The influence of varnish and high fluoride on erosion and abrasion in a laboratory investigation. Australian dental journal. 2015 Mar; 60(1):38-42. doi: 10.1111/adj.12271. [PMID: 25721276]
  • M Maciążek-Jurczyk, A Sułkowska. Spectroscopic analysis of the impact of oxidative stress on the structure of human serum albumin (HSA) in terms of its binding properties. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2015 Feb; 136 Pt B(?):265-82. doi: 10.1016/j.saa.2014.09.034. [PMID: 25448930]
  • John L Vaughn, Kejal V Shah, Maroun M Ghossein, William L Meyer, Robert B Kirkpatrick. Acute kidney injury, hyperbilirubinemia, and ischemic skin necrosis due to massive sulindac overdose. Current drug safety. 2015; 10(2):190-2. doi: 10.2174/157488631002150515150729. [PMID: 25986039]
  • Gang Xie, Ka-Wing Cheng, Liqun Huang, Basil Rigas. The in vitro metabolism of phospho-sulindac amide, a novel potential anticancer agent. Biochemical pharmacology. 2014 Sep; 91(2):249-55. doi: 10.1016/j.bcp.2014.07.007. [PMID: 25044307]
  • Joanna Lenik. Preparation and characterization of a sulindac sensor based on PVC/TOA-SUL membrane. Materials science & engineering. C, Materials for biological applications. 2014 Apr; 37(?):383-9. doi: 10.1016/j.msec.2014.01.030. [PMID: 24582264]
  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Daphna Laifenfeld, Luping Qiu, Rachel Swiss, Jennifer Park, Michael Macoritto, Yvonne Will, Husam S Younis, Michael Lawton. Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):234-48. doi: 10.1093/toxsci/kft232. [PMID: 24136188]
  • Sunny Park, Na Ra Lee, Kyung Eun Lee, Jin Young Park, Young Ju Kim, Hye Sun Gwak. Effects of single-nucleotide polymorphisms of FMO3 and FMO6 genes on pharmacokinetic characteristics of sulindac sulfide in premature labor. Drug metabolism and disposition: the biological fate of chemicals. 2014 Jan; 42(1):40-3. doi: 10.1124/dmd.113.054106. [PMID: 24173915]
  • Linda Saxe Einbond, Jason Mighty, Ryota Kashiwazaki, Mario Figueroa, Filza Jalees, Ulyana Munoz Acuna, Onica Le Gendre, David A Foster, Edward J Kennelly. Garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. Anti-cancer agents in medicinal chemistry. 2013 Dec; 13(10):1540-50. doi: 10.2174/18715206113139990095. [PMID: 23848206]
  • Ramesh Verma, Mahesh Brahmankar, Lokendra Kushwah, Balakrishnan Suresh. Evaluating the inhibitory potential of sulindac against the bleomycin-induced pulmonary fibrosis in wistar rats. Environmental toxicology and pharmacology. 2013 Nov; 36(3):769-78. doi: 10.1016/j.etap.2013.07.011. [PMID: 23958969]
  • Haonan Li, Allison L Yang, Yeon Tae Chung, Wanying Zhang, Jie Liao, Guang-Yu Yang. Sulindac inhibits pancreatic carcinogenesis in LSL-KrasG12D-LSL-Trp53R172H-Pdx-1-Cre mice via suppressing aldo-keto reductase family 1B10 (AKR1B10). Carcinogenesis. 2013 Sep; 34(9):2090-8. doi: 10.1093/carcin/bgt170. [PMID: 23689354]
  • George Mattheolabakis, Gerardo G Mackenzie, Liqun Huang, Nengtai Ouyang, Ka Wing Cheng, Basil Rigas. Topically applied phospho-sulindac hydrogel is efficacious and safe in the treatment of experimental arthritis in rats. Pharmaceutical research. 2013 Jun; 30(6):1471-82. doi: 10.1007/s11095-012-0953-8. [PMID: 23483440]
  • P Skopiński, B J Bałan, J Kocik, R Zdanowski, S Lewicki, M Niemcewicz, K Gawrychowski, E Skopińska-Różewska, W Stankiewicz. Inhibitory effect of herbal remedy PERVIVO and anti-inflammatory drug sulindac on L-1 sarcoma tumor growth and tumor angiogenesis in Balb/c mice. Mediators of inflammation. 2013; 2013(?):289789. doi: 10.1155/2013/289789. [PMID: 23935247]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Clara Curiel-Lewandrowski, Susan M Swetter, Janine G Einspahr, Chiu-Hsieh Hsu, Ray Nagle, Paul Sagerman, Joseph Tangrea, Howard Parnes, David S Alberts, Hsiao-Hui Chow. Randomized, double-blind, placebo-controlled trial of sulindac in individuals at risk for melanoma: evaluation of potential chemopreventive activity. Cancer. 2012 Dec; 118(23):5848-56. doi: 10.1002/cncr.27540. [PMID: 22605570]
  • Rongrong Zhu, Ka-Wing Cheng, Gerardo Mackenzie, Liqun Huang, Yu Sun, Gang Xie, Kveta Vrankova, Panayiotis P Constantinides, Basil Rigas. Phospho-sulindac (OXT-328) inhibits the growth of human lung cancer xenografts in mice: enhanced efficacy and mitochondria targeting by its formulation in solid lipid nanoparticles. Pharmaceutical research. 2012 Nov; 29(11):3090-101. doi: 10.1007/s11095-012-0801-x. [PMID: 22723123]
  • Howard S Moskowitz, William E Gooding, Sufi M Thomas, Maria L Freilino, Neil Gross, Athanassios Argiris, Jennifer R Grandis, Robert L Ferris. Serum biomarker modulation following molecular targeting of epidermal growth factor and cyclooxygenase pathways: a pilot randomized trial in head and neck cancer. Oral oncology. 2012 Nov; 48(11):1136-45. doi: 10.1016/j.oraloncology.2012.05.015. [PMID: 22732263]
  • Yinghua Zhang, Yan Sun, Fei Wang, Zhongping Wang, Yuwen Peng, Ruixi Li. Downregulating the canonical Wnt/β-catenin signaling pathway attenuates the susceptibility to autism-like phenotypes by decreasing oxidative stress. Neurochemical research. 2012 Jul; 37(7):1409-19. doi: 10.1007/s11064-012-0724-2. [PMID: 22374471]
  • Jean-Philippe Lafrance, Donald R Miller. Dispensed selective and nonselective nonsteroidal anti-inflammatory drugs and the risk of moderate to severe hyperkalemia: a nested case-control study. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2012 Jul; 60(1):82-9. doi: 10.1053/j.ajkd.2012.02.328. [PMID: 22503390]
  • G Xie, T Nie, G G Mackenzie, Y Sun, L Huang, N Ouyang, N Alston, C Zhu, O T Murray, P P Constantinides, L Kopelovich, B Rigas. The metabolism and pharmacokinetics of phospho-sulindac (OXT-328) and the effect of difluoromethylornithine. British journal of pharmacology. 2012 Apr; 165(7):2152-66. doi: 10.1111/j.1476-5381.2011.01705.x. [PMID: 21955327]
  • Andy J Liedtke, Brenda C Crews, Cristina M Daniel, Anna L Blobaum, Philip J Kingsley, Kebreab Ghebreselasie, Lawrence J Marnett. Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold. Journal of medicinal chemistry. 2012 Mar; 55(5):2287-300. doi: 10.1021/jm201528b. [PMID: 22263894]
  • Atil Bisgin, Aysegul Kargi, Arzu D Yalcin, Cigdem Aydin, Deniz Ekinci, Burhan Savas, Salih Sanlioglu. Increased serum sTRAIL levels were correlated with survival in bevacizumab-treated metastatic colon cancer. BMC cancer. 2012 Feb; 12(?):58. doi: 10.1186/1471-2407-12-58. [PMID: 22313795]
  • Chi C Wong, Ka-Wing Cheng, Gang Xie, Dingying Zhou, Cai-Hua Zhu, Panayiotis P Constantinides, Basil Rigas. Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity. The Journal of pharmacology and experimental therapeutics. 2012 Feb; 340(2):422-32. doi: 10.1124/jpet.111.188508. [PMID: 22085648]
  • Na Lu, Jinxing Liu, Jie Liu, Chunyun Zhang, Fuquan Jiang, Hua Wu, Liqun Chen, Wenjun Zeng, Xihua Cao, Tingdong Yan, Guanghui Wang, Hu Zhou, Bingzhen Lin, Xiaomei Yan, Xiao-kun Zhang, Jin-Zhang Zeng. Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha. PloS one. 2012; 7(4):e35722. doi: 10.1371/journal.pone.0035722. [PMID: 22545132]
  • Jean-Pascal Fournier, Maryse Lapeyre-Mestre, Agnès Sommet, Julie Dupouy, Jean-Christophe Poutrain, Jean-Louis Montastruc. Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study. PloS one. 2012; 7(3):e34187. doi: 10.1371/journal.pone.0034187. [PMID: 22479557]
  • Muhammad Khan, Chuan Ding, Azhar Rasul, Fei Yi, Ting Li, Hongwen Gao, Rong Gao, Lili Zhong, Kun Zhang, Xuedong Fang, Tonghui Ma. Isoalantolactone induces reactive oxygen species mediated apoptosis in pancreatic carcinoma PANC-1 cells. International journal of biological sciences. 2012; 8(4):533-47. doi: 10.7150/ijbs.3753. [PMID: 22532787]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Vivek Vaish, Sankar Nath Sanyal. Non steroidal anti-inflammatory drugs modulate the physicochemical properties of plasma membrane in experimental colorectal cancer: a fluorescence spectroscopic study. Molecular and cellular biochemistry. 2011 Dec; 358(1-2):161-71. doi: 10.1007/s11010-011-0931-1. [PMID: 21725642]
  • Hsin-Hsiung Tai, Xiuling Chi, Min Tong. Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs). Prostaglandins & other lipid mediators. 2011 Nov; 96(1-4):37-40. doi: 10.1016/j.prostaglandins.2011.06.005. [PMID: 21763448]
  • Kuniyasu Soda. The mechanisms by which polyamines accelerate tumor spread. Journal of experimental & clinical cancer research : CR. 2011 Oct; 30(?):95. doi: 10.1186/1756-9966-30-95. [PMID: 21988863]
  • Julia C Stingl, Thomas Ettrich, Rainer Muche, Martina Wiedom, Jürgen Brockmöller, Angela Seeringer, Thomas Seufferlein. Protocol for minimizing the risk of metachronous adenomas of the colorectum with green tea extract (MIRACLE): a randomised controlled trial of green tea extract versus placebo for nutriprevention of metachronous colon adenomas in the elderly population. BMC cancer. 2011 Aug; 11(?):360. doi: 10.1186/1471-2407-11-360. [PMID: 21851602]
  • Abdulhamaid A Maghrabi. Effect of dentin sealers on postoperative sensitivity of complete cast crowns cemented with glass ionomer cement. Journal of prosthodontics : official journal of the American College of Prosthodontists. 2011 Jul; 20(5):385-90. doi: 10.1111/j.1532-849x.2011.00724.x. [PMID: 21627710]
  • Pieter Friederich, Jelle Verschuur, Bjorn W H van Heumen, Hennie M J Roelofs, Marloes Berkhout, Iris D Nagtegaal, Martijn G H van Oijen, Johannes H J M van Krieken, Wilbert H M Peters, Fokko M Nagengast. Effects of intervention with sulindac and inulin/VSL#3 on mucosal and luminal factors in the pouch of patients with familial adenomatous polyposis. International journal of colorectal disease. 2011 May; 26(5):575-82. doi: 10.1007/s00384-010-1127-y. [PMID: 21243500]
  • L Huang, Gg Mackenzie, N Ouyang, Y Sun, G Xie, F Johnson, D Komninou, B Rigas. The novel phospho-non-steroidal anti-inflammatory drugs, OXT-328, MDC-22 and MDC-917, inhibit adjuvant-induced arthritis in rats. British journal of pharmacology. 2011 Apr; 162(7):1521-33. doi: 10.1111/j.1476-5381.2010.01162.x. [PMID: 21175575]
  • Sutharson Lingadurai, Soma Roy, Rajan Vedasiromoni Joseph, Lila Kant Nath. Antileukemic activity of the leaf extract of Bischofia javanica blume on human leukemic cell lines. Indian journal of pharmacology. 2011 Apr; 43(2):143-9. doi: 10.4103/0253-7613.77348. [PMID: 21572647]
  • Sandeep Rahar, Gaurav Swami, Navneet Nagpal, Manisha A Nagpal, Gagan Shah Singh. Preparation, characterization, and biological properties of β-glucans. Journal of advanced pharmaceutical technology & research. 2011 Apr; 2(2):94-103. doi: 10.4103/2231-4040.82953. [PMID: 22171300]
  • Charles Faselis, Michael Doumas, Vasilios Papademetriou. Common secondary causes of resistant hypertension and rational for treatment. International journal of hypertension. 2011 Mar; 2011(?):236239. doi: 10.4061/2011/236239. [PMID: 21423678]
  • Masami Suganuma, Achinto Saha, Hirota Fujiki. New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer science. 2011 Feb; 102(2):317-23. doi: 10.1111/j.1349-7006.2010.01805.x. [PMID: 21199169]
  • Naveen Babbar, Eugene W Gerner. Targeting polyamines and inflammation for cancer prevention. Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 2011; 188(?):49-64. doi: 10.1007/978-3-642-10858-7_4. [PMID: 21253788]
  • H Păunescu, O A Coman, L Coman, I Ghiţă, S R Georgescu, F Drăghia, I Fulga. Cannabinoid system and cyclooxygenases inhibitors. Journal of medicine and life. 2011 Jan; 4(1):11-20. doi: ". [PMID: 21505570]
  • Mudit Vaid, Ram Prasad, Qian Sun, Santosh K Katiyar. Silymarin targets β-catenin signaling in blocking migration/invasion of human melanoma cells. PloS one. 2011; 6(7):e23000. doi: 10.1371/journal.pone.0023000. [PMID: 21829575]
  • Toshihisa Koga, Ryoichi Fujiwara, Miki Nakajima, Tsuyoshi Yokoi. Toxicological evaluation of acyl glucuronides of nonsteroidal anti-inflammatory drugs using human embryonic kidney 293 cells stably expressing human UDP-glucuronosyltransferase and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 2011 Jan; 39(1):54-60. doi: 10.1124/dmd.110.035600. [PMID: 20926620]
  • Hamid Tayefi, Amac Kiray, Muge Kiray, Bekir Ugur Ergur, Husnu Alper Bagriyanik, Cetin Pekcetin, Mustafa Fidan, Candan Ozogul. The effects of prenatal and neonatal exposure to electromagnetic fields on infant rat myocardium. Archives of medical science : AMS. 2010 Dec; 6(6):837-42. doi: 10.5114/aoms.2010.19288. [PMID: 22427754]
  • Sittichai Koontongkaew, Paopanga Monthanapisut, Theeranuch Saensuk. Inhibition of arachidonic acid metabolism decreases tumor cell invasion and matrix metalloproteinase expression. Prostaglandins & other lipid mediators. 2010 Nov; 93(3-4):100-8. doi: 10.1016/j.prostaglandins.2010.07.002. [PMID: 20654727]
  • Thomas G Lauridsen, Henrik Vase, Jørn Starklint, Carolina C Graffe, Jesper N Bech, Søren Nielsen, Erling B Pedersen. Increased renal sodium absorption by inhibition of prostaglandin synthesis during fasting in healthy man. A possible role of the epithelial sodium channels. BMC nephrology. 2010 Oct; 11(?):28. doi: 10.1186/1471-2369-11-28. [PMID: 21029429]
  • Seung Yoon Lee, Jung Kook Suh, Jin Hwa Choi, Woo Jae Jeon, Mi Ae Cheong. Effect of ketorolac and diclofenac on the impairment of endothelium-dependent relaxation induced by reactive oxygen species in rabbit abdominal aorta. Korean journal of anesthesiology. 2010 Sep; 59(3):196-202. doi: 10.4097/kjae.2010.59.3.196. [PMID: 20877705]
  • J David Spence. Physiologic tailoring of treatment in resistant hypertension. Current cardiology reviews. 2010 May; 6(2):119-23. doi: 10.2174/157340310791162695. [PMID: 21532778]
  • Svenja D Steinbrink, Carlo Pergola, Ulrike Bühring, Sven George, Julia Metzner, Astrid S Fischer, Ann-Kathrin Häfner, Joanna M Wisniewska, Gerd Geisslinger, Oliver Werz, Dieter Steinhilber, Thorsten J Maier. Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations. Cellular and molecular life sciences : CMLS. 2010 Mar; 67(5):797-806. doi: 10.1007/s00018-009-0206-0. [PMID: 20091083]
  • J L Teeling, C Cunningham, T A Newman, V H Perry. The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1. Brain, behavior, and immunity. 2010 Mar; 24(3):409-19. doi: 10.1016/j.bbi.2009.11.006. [PMID: 19931610]
  • K Almendingen, A T Høstmark, L N Larsen, O Fausa, J Bratlie, L Aabakken. Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients. Journal of nutrition and metabolism. 2010; 2010(?):862569. doi: 10.1155/2010/862569. [PMID: 21052495]
  • Marie-Hélène Teiten, Serge Eifes, Mario Dicato, Marc Diederich. Curcumin-the paradigm of a multi-target natural compound with applications in cancer prevention and treatment. Toxins. 2010 01; 2(1):128-62. doi: 10.3390/toxins2010128. [PMID: 22069551]
  • Janmejai K Srivastava, Mitali Pandey, Sanjay Gupta. Chamomile, a novel and selective COX-2 inhibitor with anti-inflammatory activity. Life sciences. 2009 Nov; 85(19-20):663-9. doi: 10.1016/j.lfs.2009.09.007. [PMID: 19788894]
  • Wei Zou, Kevin M Beggs, Erica M Sparkenbaugh, A Daniel Jones, Husam S Younis, Robert A Roth, Patricia E Ganey. Sulindac metabolism and synergy with tumor necrosis factor-alpha in a drug-inflammation interaction model of idiosyncratic liver injury. The Journal of pharmacology and experimental therapeutics. 2009 Oct; 331(1):114-21. doi: 10.1124/jpet.109.156331. [PMID: 19638570]
  • Jean-Philippe Lafrance, Donald R Miller. Selective and non-selective non-steroidal anti-inflammatory drugs and the risk of acute kidney injury. Pharmacoepidemiology and drug safety. 2009 Oct; 18(10):923-31. doi: 10.1002/pds.1798. [PMID: 19585463]
  • Ashwani K Khanna. Enhanced susceptibility of cyclin kinase inhibitor p21 knockout mice to high fat diet induced atherosclerosis. Journal of biomedical science. 2009 Jul; 16(?):66. doi: 10.1186/1423-0127-16-66. [PMID: 19604372]
  • Gary A Piazza, Adam B Keeton, Heather N Tinsley, Bernard D Gary, Jason D Whitt, Bini Mathew, Jose Thaiparambil, Lori Coward, Gregory Gorman, Yonghe Li, Brahma Sani, Judith V Hobrath, Yulia Y Maxuitenko, Robert C Reynolds. A novel sulindac derivative that does not inhibit cyclooxygenases but potently inhibits colon tumor cell growth and induces apoptosis with antitumor activity. Cancer prevention research (Philadelphia, Pa.). 2009 Jun; 2(6):572-80. doi: 10.1158/1940-6207.capr-09-0001. [PMID: 19470791]
  • Anthony V Nguyen, Micaela Martinez, Michael J Stamos, Mary P Moyer, Kestutis Planutis, Christopher Hope, Randall F Holcombe. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer management and research. 2009 Apr; 1(?):25-37. doi: ". [PMID: 21188121]
  • Nitin Telang, Meena Katdare. Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome. Oncology reports. 2009 Apr; 21(4):1017-21. doi: 10.3892/or_00000318. [PMID: 19288003]
  • Wei Zou, Sachin S Devi, Erica Sparkenbaugh, Husam S Younis, Robert A Roth, Patricia E Ganey. Hepatotoxic interaction of sulindac with lipopolysaccharide: role of the hemostatic system. Toxicological sciences : an official journal of the Society of Toxicology. 2009 Mar; 108(1):184-93. doi: 10.1093/toxsci/kfn259. [PMID: 19074762]
  • C L O'Bryant, C H Lieu, S Leong, R Boinpally, M Basche, L Gore, K Leonardi, M K Schultz, S Hariharan, L Chow, S Diab, A Gibbs, S G Eckhardt. A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state. Cancer chemotherapy and pharmacology. 2009 Feb; 63(3):477-89. doi: 10.1007/s00280-008-0761-3. [PMID: 18509645]
  • Patrick Wortman, Yuko Miyazaki, Nishan S Kalupahana, Suyeon Kim, Melissa Hansen-Petrik, Arnold M Saxton, Kate J Claycombe, Brynn H Voy, Jay Whelan, Naima Moustaid-Moussa. n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes. Nutrition & metabolism. 2009 Jan; 6(?):5. doi: 10.1186/1743-7075-6-5. [PMID: 19159447]
  • Bing Wang, Gerd Bobe, John J LaPres, Leslie D Bourquin. High sucrose diets promote intestinal epithelial cell proliferation and tumorigenesis in APC(Min) mice by increasing insulin and IGF-I levels. Nutrition and cancer. 2009; 61(1):81-93. doi: 10.1080/01635580802372609. [PMID: 19116878]
  • Suzan Wopereis, Carina M Rubingh, Marjan J van Erk, Elwin R Verheij, Trinette van Vliet, Nicole H P Cnubben, Age K Smilde, Jan van der Greef, Ben van Ommen, Henk F J Hendriks. Metabolic profiling of the response to an oral glucose tolerance test detects subtle metabolic changes. PloS one. 2009; 4(2):e4525. doi: 10.1371/journal.pone.0004525. [PMID: 19242536]
  • Akimitsu Maeda, Shuichi Tsuruoka, Yoshikatsu Kanai, Hitoshi Endou, Kazuyuki Saito, Etsuko Miyamoto, Akio Fujimura. Evaluation of the interaction between nonsteroidal anti-inflammatory drugs and methotrexate using human organic anion transporter 3-transfected cells. European journal of pharmacology. 2008 Oct; 596(1-3):166-72. doi: 10.1016/j.ejphar.2008.08.023. [PMID: 18789319]
  • Antonio Angelini, Manuela Iezzi, Concetta Di Febbo, Carmine Di Ilio, Franco Cuccurullo, Ettore Porreca. Reversal of P-glycoprotein-mediated multidrug resistance in human sarcoma MES-SA/Dx-5 cells by nonsteroidal anti-inflammatory drugs. Oncology reports. 2008 Oct; 20(4):731-5. doi: 10.3892/or_00000067. [PMID: 18813811]
  • Fernando Santos, Lígia Teixeira, Marlene Lúcio, Helena Ferreira, Diana Gaspar, José L F C Lima, Salette Reis. Interactions of sulindac and its metabolites with phospholipid membranes: an explanation for the peroxidation protective effect of the bioactive metabolite. Free radical research. 2008 Jul; 42(7):639-50. doi: 10.1080/10715760802270326. [PMID: 18654879]
  • Chang-Yin Lee, Yi-Chao Hsu, Jir-You Wang, Chien-Chih Chen, Jen-Hwey Chiu. Chemopreventive effect of selenium and Chinese medicinal herbs on N-nitrosobis(2-oxopropyl)amine-induced hepatocellular carcinoma in Syrian hamsters. Liver international : official journal of the International Association for the Study of the Liver. 2008 Jul; 28(6):841-55. doi: 10.1111/j.1478-3231.2008.01698.x. [PMID: 18346132]
  • B Mertens, B Cahay, R Klinkenberg, B Streel. An automated method for the simultaneous determination of pravastatin, 3-hydroxy isomeric metabolite, pravalactone and fenofibric acid in human plasma by sensitive liquid chromatography combined with diode array and tandem mass spectrometry detection. Journal of chromatography. A. 2008 May; 1189(1-2):493-502. doi: 10.1016/j.chroma.2008.01.060. [PMID: 18342321]
  • Martin Gamerdinger, Angela B Clement, Christian Behl. Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase. Neuropharmacology. 2008 May; 54(6):998-1005. doi: 10.1016/j.neuropharm.2008.02.009. [PMID: 18359496]