Xanthohumol (BioDeep_00000269455)

Main id: BioDeep_00000230032

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2,4,4-trihydroxy-6-methoxy-3-prenylchalcone

化学式: C21H22O5 (354.1467)
中文名称: 黄腐酚
谱图信息: 最多检出来源 Viridiplantae(plant) 88.89%

分子结构信息

SMILES: CC(=CCC1=C(C(=C(C=C1O)OC)C(=O)C=CC2=CC=C(C=C2)O)O)C
InChI: InChI=1S/C21H22O5/c1-13(2)4-10-16-18(24)12-19(26-3)20(21(16)25)17(23)11-7-14-5-8-15(22)9-6-14/h4-9,11-12,22,24-25H,10H2,1-3H3/b11-7+

描述信息

C308 - Immunotherapeutic Agent > C63817 - Chemokine Receptor Antagonist > C107589 - CXCR4 Inhibitor
Acquisition and generation of the data is financially supported by the Max-Planck-Society
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents
D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors
D006133 - Growth Substances > D006131 - Growth Inhibitors
C1892 - Chemopreventive Agent
IPB_RECORD: 2221; CONFIDENCE confident structure
IPB_RECORD: 4121; CONFIDENCE confident structure
IPB_RECORD: 4101; CONFIDENCE confident structure
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).
Xanthohumol is one of the principal flavonoids isolated from hops, the inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1 and COX-2, and shows anti-cancer and anti-angiogenic activities. Xanthohumol also has antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2 and cytomegalovirus (CMV).

同义名列表

6 个代谢物同义名

Xanthohumol; Xanthohumol (MSe); Xanthohumol/Isoxanthohumol; Isoxanthohumol; 2,4,4-trihydroxy-6-methoxy-3-prenylchalcone; Xanthohumol



数据库引用编号

58 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

45 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, ANG, ANXA5, BCL2, CASP3, CCND1, KEAP1, MTOR, NOS2, PIK3CA, PTGS2, TLR4, VEGFA
Peripheral membrane protein 4 ANXA5, CYP1B1, MTOR, PTGS2
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 5 BCL2, CYP1B1, HMOX1, MTOR, PTGS2
Nucleus 13 AKT1, ANG, BCL2, CASP3, CCND1, FOS, GABPA, HMOX1, KEAP1, MTOR, NOS2, PARP1, VEGFA
cytosol 13 AKT1, ANG, ANXA5, BCL2, CASP3, CCND1, FOS, HMOX1, KEAP1, MTOR, NOS2, PARP1, PIK3CA
dendrite 1 MTOR
nuclear body 1 PARP1
phagocytic vesicle 1 MTOR
centrosome 1 CCND1
nucleoplasm 10 AKT1, CASP3, CCND1, FOS, GABPA, HMOX1, KEAP1, MTOR, NOS2, PARP1
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 2 AKT1, TLR4
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 MTOR
cell cortex 1 AKT1
cell surface 2 TLR4, VEGFA
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 1 VEGFA
Golgi membrane 2 INS, MTOR
growth cone 1 ANG
lysosomal membrane 1 MTOR
neuronal cell body 2 ANG, CASP3
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 2 NOS2, PARP1
Lysosome 1 MTOR
plasma membrane 4 AKT1, NOS2, PIK3CA, TLR4
Membrane 9 AKT1, ANXA5, BCL2, CYP1B1, HMOX1, MTOR, PARP1, TLR4, VEGFA
caveola 1 PTGS2
extracellular exosome 1 ANXA5
Lysosome membrane 1 MTOR
endoplasmic reticulum 6 BCL2, FOS, HMOX1, KEAP1, PTGS2, VEGFA
extracellular space 5 ANG, HMOX1, IL6, INS, VEGFA
perinuclear region of cytoplasm 4 HMOX1, NOS2, PIK3CA, TLR4
adherens junction 1 VEGFA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CYP1B1, PARP1
protein-containing complex 4 AKT1, BCL2, PARP1, PTGS2
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 3 CYP1B1, MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 4 ANG, IL6, INS, VEGFA
extracellular region 5 ANG, ANXA5, IL6, INS, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
transcription regulator complex 1 PARP1
centriolar satellite 1 KEAP1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 2 ANXA5, TLR4
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
microtubule cytoskeleton 1 AKT1
nucleolus 2 ANG, PARP1
midbody 1 KEAP1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
cell-cell junction 1 AKT1
vesicle 1 AKT1
Cytoplasm, perinuclear region 1 NOS2
pore complex 1 BCL2
focal adhesion 1 ANXA5
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 NOS2
basement membrane 1 ANG
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 FOS, GABPA, PARP1
phagocytic cup 1 TLR4
Chromosome 2 ANG, PARP1
Nucleus, nucleolus 2 ANG, PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
actin filament 1 KEAP1
site of double-strand break 1 PARP1
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 2 MTOR, PARP1
Endomembrane system 1 MTOR
endosome lumen 1 INS
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 FOS
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
vesicle membrane 1 ANXA5
protein-DNA complex 2 FOS, PARP1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
site of DNA damage 1 PARP1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
transcription factor AP-1 complex 1 FOS
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • Wan-Yun Gao, Pei-Yi Chen, Hao-Jen Hsu, Je-Wen Liou, Chia-Ling Wu, Ming-Jiuan Wu, Jui-Hung Yen. Xanthohumol, a prenylated chalcone, regulates lipid metabolism by modulating the LXRα/RXR-ANGPTL3-LPL axis in hepatic cell lines and high-fat diet-fed zebrafish models. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 May; 174(?):116598. doi: 10.1016/j.biopha.2024.116598. [PMID: 38615609]
  • Yanyan Deng, Xiayan Chu, Qian Li, Guanghao Zhu, Jing Hu, Jianming Sun, Hairong Zeng, Jian Huang, Guangbo Ge. Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155458. doi: 10.1016/j.phymed.2024.155458. [PMID: 38394733]
  • Ewa Oledzka. Xanthohumol-A Miracle Molecule with Biological Activities: A Review of Biodegradable Polymeric Carriers and Naturally Derived Compounds for Its Delivery. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063398. [PMID: 38542371]
  • Ranjith Palanisamy, Nimnaka Indrajith Kahingalage, David Archibald, Ilaria Casari, Marco Falasca. Synergistic Anticancer Activity of Plumbagin and Xanthohumol Combination on Pancreatic Cancer Models. International journal of molecular sciences. 2024 Feb; 25(4):. doi: 10.3390/ijms25042340. [PMID: 38397018]
  • Natalia Kasica, Jerzy Kaleczyc. Xanthohumol, a prenylated flavonoid from hops (Humulus lupulus L.) exerts multidirectional pro-healing properties towards damaged zebrafish hair cells by regulating the innate immune response. Toxicology and applied pharmacology. 2024 Jan; 483(?):116809. doi: 10.1016/j.taap.2024.116809. [PMID: 38211931]
  • Shan Yang, Ruibing Chen, Xuan Cao, Guodong Wang, Yongjin J Zhou. De novo biosynthesis of the hops bioactive flavonoid xanthohumol in yeast. Nature communications. 2024 Jan; 15(1):253. doi: 10.1038/s41467-023-44654-5. [PMID: 38177132]
  • Anna-Maria Herzog, Katharina Göbel, Luigi Marongiu, Natalia Ruetalo, Marta Campos Alonso, Christian Leischner, Christian Busch, Markus Burkard, Ulrich M Lauer, Paul P Geurink, Klaus-Peter Knobeloch, Michael Schindler, Günter Fritz, Sascha Venturelli. Compounds derived from Humulus lupulus inhibit SARS-CoV-2 papain-like protease and virus replication. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155176. doi: 10.1016/j.phymed.2023.155176. [PMID: 37976697]
  • Paige E Jamieson, Eli B Smart, John A Bouranis, Jaewoo Choi, Robert E Danczak, Carmen P Wong, Ines L Paraiso, Claudia S Maier, Emily Ho, Thomas J Sharpton, Thomas O Metz, Ryan Bradley, Jan F Stevens. Gut enterotype-dependent modulation of gut microbiota and their metabolism in response to xanthohumol supplementation in healthy adults. Gut microbes. 2024 Jan; 16(1):2315633. doi: 10.1080/19490976.2024.2315633. [PMID: 38358253]
  • Qin Wang, Tao Chen, Zhen Shuqing, Liangzhu Yu, Shaohui Chen, Hong Lu, Haili Zhu, Xie Min, Xiong Li, Ling Liu. Xanthohumol relieves arthritis pain in mice by suppressing mitochondrial-mediated inflammation. Molecular pain. 2023 Sep; ?(?):17448069231204051. doi: 10.1177/17448069231204051. [PMID: 37699859]
  • Ali Q Alorabi, Hussain Alessa, Nasser A Alamrani, Ahmad A Alluhaybi, Zehbah A Al-Ahmed, Ali Sayqal, Hana M Abumelha, Nashwa M El-Metwaly. Preparation of green colorimetric pH sensor using Humulus lupulus L. (common hop) biomolecular extract for sweat monitoring. Luminescence : the journal of biological and chemical luminescence. 2023 Aug; 38(8):1431-1439. doi: 10.1002/bio.4511. [PMID: 37081595]
  • Xiaoqing Yuan, Hong Wang, Shuyi Song, Lili Qiu, Xianming Lan, Pingping Dong, Jiayu Zhang. Stepwise Targeted Matching Strategy for Comprehensive Profiling of Xanthohumol Metabolites In Vivo and In Vitro Using UHPLC-Q-Exactive Orbitrap Mass Spectrometer. Molecules (Basel, Switzerland). 2023 Jul; 28(13):. doi: 10.3390/molecules28135168. [PMID: 37446828]
  • Fa-Li Zhang, Liu Yang, Wei-Hao He, Ling-Jun Xie, Fei Yang, Ying-Hui Wang, Ai-Guo Huang. In vivo antibacterial activity of medicinal plant Sophora flavescens against Streptococcus agalactiae infection. Journal of fish diseases. 2023 Jun; ?(?):. doi: 10.1111/jfd.13818. [PMID: 37294673]
  • Byungjick Min, Yejin Ahn, Hyeok-Jun Cho, Woong-Kwon Kwak, Kyungae Jo, Hyung Joo Suh. Chemical compositions and sleep-promoting activities of hop (Humulus lupulus L.) varieties. Journal of food science. 2023 May; 88(5):2217-2228. doi: 10.1111/1750-3841.16544. [PMID: 37038885]
  • Chiara Corrado, Maria Magdalena Barreca, Stefania Raimondo, Patrizia Diana, Giacomo Pepe, Maria Giovanna Basilicata, Alice Conigliaro, Riccardo Alessandro. Nobiletin and xanthohumol counteract the TNFα-mediated activation of endothelial cells through the inhibition of the NF-κB signaling pathway. Cell biology international. 2023 Mar; 47(3):634-647. doi: 10.1002/cbin.11963. [PMID: 36378586]
  • Vancha Harish, Waleed Hassan Almalki, Ahmed Alshehri, Abdulaziz Alzahrani, Madan Mohan Gupta, Sami I Alzarea, Imran Kazmi, Monica Gulati, Devesh Tewari, Gaurav Gupta, Kamal Dua, Sachin Kumar Singh. Quality by Design (QbD) Based Method for Estimation of Xanthohumol in Bulk and Solid Lipid Nanoparticles and Validation. Molecules (Basel, Switzerland). 2023 Jan; 28(2):. doi: 10.3390/molecules28020472. [PMID: 36677532]
  • Sun Xiao-Lei, Xia Tian-Shuang, Jiang Yi-Ping, Wang Na-Ni, Xu Ling-Chuan, Han Ting, Xin Hai-Liang. Humulus lupulus L. extract and its active constituent xanthohumol attenuate oxidative stress and nerve injury induced by iron overload via activating AKT/GSK3β and Nrf2/NQO1 pathways. Journal of natural medicines. 2023 Jan; 77(1):12-27. doi: 10.1007/s11418-022-01642-1. [PMID: 36074228]
  • Christian Niederau, Shruti Bhargava, Rebekka Schneider-Kramman, Joachim Jankowski, Rogerio B Craveiro, Michael Wolf. Xanthohumol exerts anti-inflammatory effects in an in vitro model of mechanically stimulated cementoblasts. Scientific reports. 2022 Sep; 12(1):14970. doi: 10.1038/s41598-022-19220-6. [PMID: 36056072]
  • Tianshuang Xia, Xiaoyan Liu, Nani Wang, Yiping Jiang, Huanhuan Bai, Weifan Xu, Kunmiao Feng, Ting Han, Hailiang Xin. PI3K/AKT/Nrf2 signalling pathway is involved in the ameliorative effects of xanthohumol on amyloid β-induced oxidative damage and bone loss. The Journal of pharmacy and pharmacology. 2022 Jul; 74(7):1017-1026. doi: 10.1093/jpp/rgac007. [PMID: 35353176]
  • Margalida Torrens-Mas, Marina Alorda-Clara, Maria Martínez-Vigara, Pilar Roca, Jorge Sastre-Serra, Jordi Oliver, Daniel Gabriel Pons. Xanthohumol reduces inflammation and cell metabolism in HT29 primary colon cancer cells. International journal of food sciences and nutrition. 2022 Jun; 73(4):471-479. doi: 10.1080/09637486.2021.2012561. [PMID: 34879764]
  • Xiaolei Sun, Tianshuang Xia, Shiyao Zhang, Jiabao Zhang, Lingchuan Xu, Ting Han, Hailiang Xin. Hops extract and xanthohumol ameliorate bone loss induced by iron overload via activating Akt/GSK3β/Nrf2 pathway. Journal of bone and mineral metabolism. 2022 May; 40(3):375-388. doi: 10.1007/s00774-021-01295-2. [PMID: 35106609]
  • Hannah F Neumann, Jan Frank, Sascha Venturelli, Sarah Egert. Bioavailability and Cardiometabolic Effects of Xanthohumol: Evidence from Animal and Human Studies. Molecular nutrition & food research. 2022 03; 66(6):e2100831. doi: 10.1002/mnfr.202100831. [PMID: 34967501]
  • Huan-Huan Bai, Tian-Shuang Xia, Yi-Ping Jiang, Wu-Mu Xu, Ping-Cui Xu, Na-Ni Wang, Xiao-Jun Gou, Hai-Liang Xin. Absorption, metabolism, and pharmacokinetic profile of xanthohumol in rats as determined via UPLC-MS/MS. Biopharmaceutics & drug disposition. 2022 Feb; 43(1):11-22. doi: 10.1002/bdd.2306. [PMID: 34914109]
  • Jian-Hong Lin, Kun-Ta Yang, Wen-Sen Lee, Pei-Ching Ting, Yu-Po Luo, Ding-Jyun Lin, Yi-Shun Wang, Jui-Chih Chang. Xanthohumol Protects the Rat Myocardium against Ischemia/Reperfusion Injury-Induced Ferroptosis. Oxidative medicine and cellular longevity. 2022; 2022(?):9523491. doi: 10.1155/2022/9523491. [PMID: 35082973]
  • Yuxi Lin, Ruochen Zang, Yanlong Ma, Zhuoya Wang, Li Li, Siyuan Ding, Rong Zhang, Zhiqiang Wei, Jinbo Yang, Xin Wang. Xanthohumol Is a Potent Pan-Inhibitor of Coronaviruses Targeting Main Protease. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212134. [PMID: 34830015]
  • Javier Fernández, Blanca Silván, Rodrigo Entrialgo-Cadierno, Claudio J Villar, Raffaele Capasso, José Antonio Uranga, Felipe Lombó, Raquel Abalo. Antiproliferative and palliative activity of flavonoids in colorectal cancer. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Nov; 143(?):112241. doi: 10.1016/j.biopha.2021.112241. [PMID: 34649363]
  • Isabelle E Logan, Natalia Shulzhenko, Thomas J Sharpton, Gerd Bobe, Kitty Liu, Stephanie Nuss, Megan L Jones, Cristobal L Miranda, Stephany Vasquez-Perez, Jamie M Pennington, Scott W Leonard, Jaewoo Choi, Wenbin Wu, Manoj Gurung, Joyce P Kim, Malcolm B Lowry, Andrey Morgun, Claudia S Maier, Jan F Stevens, Adrian F Gombart. Xanthohumol Requires the Intestinal Microbiota to Improve Glucose Metabolism in Diet-Induced Obese Mice. Molecular nutrition & food research. 2021 11; 65(21):e2100389. doi: 10.1002/mnfr.202100389. [PMID: 34496124]
  • Marcel Karabín, Tereza Haimannová, Kristýna Fialová, Lukáš Jelínek, Pavel Dostálek. Preparation of Hop Estrogen-Active Material for Production of Food Supplements. Molecules (Basel, Switzerland). 2021 Oct; 26(19):. doi: 10.3390/molecules26196065. [PMID: 34641609]
  • Xiao-Lei Sun, Jia-Bao Zhang, Yun-Xiang Guo, Tian-Shuang Xia, Ling-Chuan Xu, Khalid Rahmand, Guo-Ping Wang, Xiao-Jin Li, Ting Han, Na-Ni Wang, Hai-Liang Xin. Xanthohumol ameliorates memory impairment and reduces the deposition of β-amyloid in APP/PS1 mice via regulating the mTOR/LC3II and Bax/Bcl-2 signalling pathways. The Journal of pharmacy and pharmacology. 2021 Aug; 73(9):1230-1239. doi: 10.1093/jpp/rgab052. [PMID: 33909081]
  • Yang Zhang, Gerd Bobe, Cristobal L Miranda, Malcolm B Lowry, Victor L Hsu, Christiane V Lohr, Carmen P Wong, Donald B Jump, Matthew M Robinson, Thomas J Sharpton, Claudia S Maier, Jan F Stevens, Adrian F Gombart. Tetrahydroxanthohumol, a xanthohumol derivative, attenuates high-fat diet-induced hepatic steatosis by antagonizing PPARγ. eLife. 2021 06; 10(?):. doi: 10.7554/elife.66398. [PMID: 34128467]
  • Vancha Harish, Effi Haque, Magdalena Śmiech, Hiroaki Taniguchi, Sarah Jamieson, Devesh Tewari, Anupam Bishayee. Xanthohumol for Human Malignancies: Chemistry, Pharmacokinetics and Molecular Targets. International journal of molecular sciences. 2021 Apr; 22(9):. doi: 10.3390/ijms22094478. [PMID: 33923053]
  • Ankur Kumar Tanwar, Neha Dhiman, Amit Kumar, Vikas Jaitak. Engagement of phytoestrogens in breast cancer suppression: Structural classification and mechanistic approach. European journal of medicinal chemistry. 2021 Mar; 213(?):113037. doi: 10.1016/j.ejmech.2020.113037. [PMID: 33257172]
  • Diwakar Aggarwal, Sushil K Upadhyay, Raj Singh, Hardeep S Tuli. Recent patents on therapeutic activities of xanthohumol: a prenylated chalconoid from hops (Humulus lupulus L.). Pharmaceutical patent analyst. 2021 Jan; 10(1):37-49. doi: 10.4155/ppa-2020-0026. [PMID: 33445965]
  • Takeshi Yokoyama, Mineyuki Mizuguchi. Transthyretin Amyloidogenesis Inhibitors: From Discovery to Current Developments. Journal of medicinal chemistry. 2020 12; 63(23):14228-14242. doi: 10.1021/acs.jmedchem.0c00934. [PMID: 32914975]
  • Ryan Bradley, Blake O Langley, Jennifer J Ryan, John Phipps, Douglas A Hanes, Emily Stack, Janet K Jansson, Thomas O Metz, Jan Frederik Stevens. Xanthohumol microbiome and signature in healthy adults (the XMaS trial): a phase I triple-masked, placebo-controlled clinical trial. Trials. 2020 Oct; 21(1):835. doi: 10.1186/s13063-020-04769-2. [PMID: 33028396]
  • Gopalsamy Rajiv Gandhi, Alan Bruno Silva Vasconcelos, Ding-Tao Wu, Hua-Bin Li, Poovathumkal James Antony, Hang Li, Fang Geng, Ricardo Queiroz Gurgel, Narendra Narain, Ren-You Gan. Citrus Flavonoids as Promising Phytochemicals Targeting Diabetes and Related Complications: A Systematic Review of In Vitro and In Vivo Studies. Nutrients. 2020 Sep; 12(10):. doi: 10.3390/nu12102907. [PMID: 32977511]
  • Beata Nowak, Błażej Poźniak, Jarosław Popłoński, Łukasz Bobak, Agnieszka Matuszewska, Joanna Kwiatkowska, Wojciech Dziewiszek, Ewa Huszcza, Adam Szeląg. Pharmacokinetics of xanthohumol in rats of both sexes after oral and intravenous administration of pure xanthohumol and prenylflavonoid extract. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2020 09; 29(9):1101-1109. doi: 10.17219/acem/126293. [PMID: 32996724]
  • Ines L Paraiso, Johana S Revel, Jaewoo Choi, Cristobal L Miranda, Parnian Lak, Chrissa Kioussi, Gerd Bobe, Adrian F Gombart, Jacob Raber, Claudia S Maier, Jan F Stevens. Targeting the Liver-Brain Axis with Hop-Derived Flavonoids Improves Lipid Metabolism and Cognitive Performance in Mice. Molecular nutrition & food research. 2020 08; 64(15):e2000341. doi: 10.1002/mnfr.202000341. [PMID: 32627931]
  • Francisco Donoso, Sian Egerton, Thomaz F S Bastiaanssen, Patrick Fitzgerald, Snehal Gite, Fiona Fouhy, R Paul Ross, Catherine Stanton, Timothy G Dinan, John F Cryan. Polyphenols selectively reverse early-life stress-induced behavioural, neurochemical and microbiota changes in the rat. Psychoneuroendocrinology. 2020 06; 116(?):104673. doi: 10.1016/j.psyneuen.2020.104673. [PMID: 32334345]
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