aphidicolin (BioDeep_00000002638)

 

Secondary id: BioDeep_00001871091

natural product PANOMIX_OTCML-2023


代谢物信息卡片


8,11|A-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-

化学式: C20H34O4 (338.2457)
中文名称: 艾菲地可宁
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 6.16%

分子结构信息

SMILES: C1[C@H]([C@@]([C@H]2[C@](C1)([C@]13[C@@H](CC2)C[C@H](C1)[C@@](CC3)(O)CO)C)(C)CO)O
InChI: InChI=1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

描述信息

A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication.
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D004791 - Enzyme Inhibitors

同义名列表

8 个代谢物同义名

(+)-Aphidicolin; aphidicolin; Aphidicolane-3alpha,16,17,18-tetraol; 8,11|A-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-; CC12Ccc(O)C(C)(CO)C2ccc3CC4CC13ccc4(O)CO; Aphidicolin from Nigrospora sphaerica; APC; Aphidicolin



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

55 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ATM, BCL2, CDK1, CDK2, CDKN1A, CDKN2A, CHEK1, DHFR, FHIT, MRE11, MYC, POLB, PRKX, RAD51, TUBB4B
Endoplasmic reticulum membrane 2 BCL2, CDK1
Nucleus 18 ATM, BCL2, CDK1, CDK2, CDKN1A, CDKN2A, CHEK1, FANCD2, FHIT, H2AX, MRE11, MYC, PCNA, POLB, PRKX, RAD51, TOP1, TUBB4B
cytosol 13 ATM, BCL2, CDK1, CDK2, CDKN1A, CDKN2A, CHEK1, DHFR, FANCD2, FHIT, MRE11, RAD51, TUBB4B
nuclear body 3 CDKN1A, FANCD2, PCNA
centrosome 7 ATM, CDK1, CDK2, CHEK1, H2AX, PCNA, RAD51
nucleoplasm 15 ATM, CDK1, CDK2, CDKN1A, CDKN2A, CHEK1, FANCD2, H2AX, MRE11, MYC, PCNA, POLB, PRKX, RAD51, TOP1
endosome 1 CDK2
plasma membrane 1 FHIT
Membrane 3 BCL2, CDK1, MYC
extracellular exosome 4 CDK1, H2AX, PCNA, TUBB4B
endoplasmic reticulum 1 BCL2
extracellular space 1 CHEK1
perinuclear region of cytoplasm 2 CDKN1A, RAD51
mitochondrion 6 BCL2, CDK1, CDKN2A, DHFR, FHIT, RAD51
protein-containing complex 7 BCL2, CDKN1A, CDKN2A, CHEK1, MYC, POLB, RAD51
intracellular membrane-bounded organelle 2 ATM, CHEK1
extracellular region 1 TUBB4B
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 RAD51
mitochondrial matrix 3 CDK1, CDKN2A, RAD51
transcription regulator complex 1 CDK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 5 ATM, CDK1, CDK2, CHEK1, RAD51
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
Extracellular vesicle 1 TUBB4B
perikaryon 1 TOP1
cytoplasmic vesicle 1 ATM
microtubule cytoskeleton 1 TUBB4B
nucleolus 7 ATM, CDKN1A, CDKN2A, FANCD2, MYC, RAD51, TOP1
midbody 1 CDK1
P-body 1 TOP1
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TUBB4B
microtubule 2 POLB, TUBB4B
spindle 1 ATM
Peroxisome matrix 1 ATM
peroxisomal matrix 1 ATM
PML body 2 MRE11, RAD51
nuclear speck 1 H2AX
chromatin 5 CHEK1, FANCD2, MYC, PCNA, RAD51
mitotic spindle 2 CDK1, TUBB4B
Chromosome 5 CHEK1, H2AX, MRE11, RAD51, TOP1
cytoskeleton 1 TUBB4B
Nucleus, nucleolus 3 CDKN2A, MYC, TOP1
nuclear replication fork 1 PCNA
Chromosome, telomere 1 MRE11
chromosome, telomeric region 5 CDK1, CDK2, MRE11, PCNA, RAD51
nuclear chromosome 1 RAD51
site of double-strand break 4 ATM, H2AX, MRE11, RAD51
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
fibrillar center 2 FHIT, TOP1
nuclear envelope 2 CDK2, MYC
axonemal microtubule 1 TUBB4B
lateral element 1 RAD51
Nucleus, nucleoplasm 3 CDKN2A, MYC, TOP1
replication fork 4 CHEK1, H2AX, MRE11, PCNA
myelin sheath 1 BCL2
male germ cell nucleus 5 CDK2, H2AX, PCNA, RAD51, TOP1
XY body 1 H2AX
extrinsic component of synaptic vesicle membrane 1 ATM
RNA polymerase II transcription repressor complex 1 MYC
azurophil granule lumen 1 TUBB4B
condensed nuclear chromosome 3 CHEK1, H2AX, RAD51
nuclear lamina 1 PCNA
Cajal body 1 CDK2
protein-DNA complex 1 TOP1
spindle microtubule 2 CDK1, POLB
nucleosome 1 H2AX
Rough endoplasmic reticulum 1 MYC
condensed chromosome 3 CDK2, FANCD2, RAD51
DNA repair complex 2 ATM, FANCD2
Nucleus, Cajal body 1 CDK2
BRCA1-C complex 1 MRE11
chromosomal region 1 MRE11
Mre11 complex 1 MRE11
X chromosome 1 CDK2
Y chromosome 1 CDK2
site of DNA damage 1 H2AX
cyclin-dependent protein kinase holoenzyme complex 4 CDK1, CDK2, CDKN1A, PCNA
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
Myc-Max complex 1 MYC
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 1 CDK1
presynaptic intermediate filament cytoskeleton 1 RAD51
BAD-BCL-2 complex 1 BCL2
PCNA complex 1 PCNA
PCNA-p21 complex 2 CDKN1A, PCNA
replisome 1 PCNA
senescence-associated heterochromatin focus 1 CDKN2A
cyclin A2-CDK2 complex 1 CDK2
cyclin A1-CDK2 complex 1 CDK2
nuclear ubiquitin ligase complex 1 RAD51
[Isoform smARF]: Mitochondrion 1 CDKN2A
nucleoplasmic reticulum 1 MYC


文献列表

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