NCBI Taxonomy: 29910
Tolypocladium inflatum (ncbi_taxid: 29910)
found 32 associated metabolites at species taxonomy rank level.
Ancestor: Tolypocladium
Child Taxonomies: Tolypocladium inflatum NRRL8044
Cyclosporine
Cyclosporine (Neoral)
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents > D003524 - Cyclosporins D004791 - Enzyme Inhibitors > D065095 - Calcineurin Inhibitors D000890 - Anti-Infective Agents > D000935 - Antifungal Agents D018501 - Antirheumatic Agents D003879 - Dermatologic Agents Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of protein phosphatase 2B (PP2B/calcineurin) with an IC50 of 5 nM[3]. Cyclosporin A also inhibits CD11a/CD18 adhesion[8].
aphidicolin
8,11|A-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol,tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
A tetracyclic diterpenoid that has an tetradecahydro-8,11a-methanocyclohepta[a]naphthalene skeleton with two hydroxymethyl substituents at positions 4 and 9, two methyl substituents at positions 4 and 11b and two hydroxy substituents at positions 3 and 9. An antibiotic with antiviral and antimitotical properties. Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. D000890 - Anti-Infective Agents > D000998 - Antiviral Agents D004791 - Enzyme Inhibitors
3-Epiaphidicolin
(3-a,4-a,5-a,17-a)-3,17-Dihydroxy-4-methyl-9,15-cyclo-C,18-dinor-14,15-secoandrostane-4,17-dimethanol
Cyclosporin A
30-ethyl-33-(1-hydroxy-2-methylhex-4-en-1-yl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
17-(hydroxymethyl)-7-(4-hydroxyphenyl)-2,10-dimethyl-6,8-dioxapentacyclo[14.3.1.0¹,¹⁴.0²,¹¹.0⁵,¹⁰]icosan-17-ol
17-(hydroxymethyl)-7-(4-hydroxyphenyl)-2,10-dimethyl-6,8-dioxapentacyclo[14.3.1.0¹,¹⁴.0²,¹¹.0⁵,¹⁰]icosan-17-ol
14,17,23,26,32-pentahydroxy-33-(1-hydroxy-2-methylhex-4-en-1-yl)-30-(1-hydroxyethyl)-3,21,24-triisopropyl-1,4,7,10,12,15,19,28-octamethyl-6,9,18-tris(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,25,31-pentaene-2,5,8,11,20,29-hexone
14,17,23,26,32-pentahydroxy-33-(1-hydroxy-2-methylhex-4-en-1-yl)-30-(1-hydroxyethyl)-3,21,24-triisopropyl-1,4,7,10,12,15,19,28-octamethyl-6,9,18-tris(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,25,31-pentaene-2,5,8,11,20,29-hexone
(3r,6s,9s,12r,15s,18s,21s,24s,30s,33s)-14,17,23,26,32-pentahydroxy-33-[(1r,2r,4e)-1-hydroxy-2-methylhex-4-en-1-yl]-30-[(1r)-1-hydroxyethyl]-3,21,24-triisopropyl-1,4,7,10,12,15,19,28-octamethyl-6,9,18-tris(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,25,31-pentaene-2,5,8,11,20,29-hexone
(3r,6s,9s,12r,15s,18s,21s,24s,30s,33s)-14,17,23,26,32-pentahydroxy-33-[(1r,2r,4e)-1-hydroxy-2-methylhex-4-en-1-yl]-30-[(1r)-1-hydroxyethyl]-3,21,24-triisopropyl-1,4,7,10,12,15,19,28-octamethyl-6,9,18-tris(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,25,31-pentaene-2,5,8,11,20,29-hexone
(3r,6s,9s,12r,15s,18r,21s,24s,30s,33s)-14,17,23,32-tetrahydroxy-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24,33-pentakis(2-methylpropyl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,31-tetraene-2,5,8,11,20,26,29-heptone
(3r,6s,9s,12r,15s,18r,21s,24s,30s,33s)-14,17,23,32-tetrahydroxy-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24,33-pentakis(2-methylpropyl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,31-tetraene-2,5,8,11,20,26,29-heptone
(3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-14,17,23,32-tetrahydroxy-33-[(1r,2r,4e)-1-hydroxy-2-methylhex-4-en-1-yl]-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,31-tetraene-2,5,8,11,20,26,29-heptone
(3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-14,17,23,32-tetrahydroxy-33-[(1r,2r,4e)-1-hydroxy-2-methylhex-4-en-1-yl]-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,31-tetraene-2,5,8,11,20,26,29-heptone
(3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-30-ethyl-14,17,23,32-tetrahydroxy-33-[(1r,2r,4e)-1-hydroxy-2-methylhex-4-en-1-yl]-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,31-tetraene-2,5,8,11,20,26,29-heptone
(3s,6s,9s,12r,15s,18s,21s,24s,30s,33s)-30-ethyl-14,17,23,32-tetrahydroxy-33-[(1r,2r,4e)-1-hydroxy-2-methylhex-4-en-1-yl]-3,21-diisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,22,31-tetraene-2,5,8,11,20,26,29-heptone
8,14,23,26,32-pentahydroxy-9-(1-hydroxy-2-methylhex-4-en-1-yl)-6-(1-hydroxyethyl)-12,30-diisopropyl-1,4,10,16,19,21,24,28-octamethyl-15,18,27,33-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-7,13,22,25,31-pentaene-2,5,11,17,20,29-hexone
8,14,23,26,32-pentahydroxy-9-(1-hydroxy-2-methylhex-4-en-1-yl)-6-(1-hydroxyethyl)-12,30-diisopropyl-1,4,10,16,19,21,24,28-octamethyl-15,18,27,33-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-7,13,22,25,31-pentaene-2,5,11,17,20,29-hexone
C61H109N11O13 (1203.8205904000001)
14,17,20,23,32-pentahydroxy-33-(1-hydroxy-2-methylhex-4-en-1-yl)-3,21-diisopropyl-1,4,7,10,12,15,25,28-octamethyl-6,9,18,24-tetrakis(2-methylpropyl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,19,22,31-pentaene-2,5,8,11,26,29-hexone
14,17,20,23,32-pentahydroxy-33-(1-hydroxy-2-methylhex-4-en-1-yl)-3,21-diisopropyl-1,4,7,10,12,15,25,28-octamethyl-6,9,18,24-tetrakis(2-methylpropyl)-30-propyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-13,16,19,22,31-pentaene-2,5,8,11,26,29-hexone
(6s,9s,12s,15s,18s,21r,24s,27s,30s,33s)-8,17,23,26,32-pentahydroxy-9-[(1r,2r,4e)-1-hydroxy-2-methylhex-4-en-1-yl]-6,12,30-triisopropyl-1,4,10,13,19,21,24,28-octamethyl-15,18,27,33-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-7,16,22,25,31-pentaene-2,5,11,14,20,29-hexone
(6s,9s,12s,15s,18s,21r,24s,27s,30s,33s)-8,17,23,26,32-pentahydroxy-9-[(1r,2r,4e)-1-hydroxy-2-methylhex-4-en-1-yl]-6,12,30-triisopropyl-1,4,10,13,19,21,24,28-octamethyl-15,18,27,33-tetrakis(2-methylpropyl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriaconta-7,16,22,25,31-pentaene-2,5,11,14,20,29-hexone