Glucoraphanin (BioDeep_00000002610)

Main id: BioDeep_00000230230

 

natural product human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


{[(Z)-(5-methanesulfinyl-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyl}pentylidene)amino]oxy}sulfonic acid

化学式: C12H23NO10S3 (437.0484)
中文名称: 葡甘氨酸钾盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(=N\OS(=O)(=O)O)(\S[C@H]1O[C@H]([C@@H]([C@H]([C@H]1O)O)O)CO)/CCCC[S@](=O)C
InChI: InChI=1S/C12H23NO10S3/c1-25(18)5-3-2-4-8(13-23-26(19,20)21)24-12-11(17)10(16)9(15)7(6-14)22-12/h7,9-12,14-17H,2-6H2,1H3,(H,19,20,21)/t7-,9-,10+,11-,12+,25?/m1/s1

描述信息

Glucoraphanin belongs to the class of organic compounds known as alkylglucosinolates. These are organic compounds containing a glucosinolate moiety that carries an alkyl chain. Outside of the human body, glucoraphanin has been detected, but not quantified in, several different foods, such as radish, common cabbages, Brassicas, Chinese cabbages, and cabbages. This could make glucoraphanin a potential biomarker for the consumption of these foods.
Isolated from radish (Raphanus sativus) and Brassica species seeds or tops. Glucoraphanin is found in many foods, some of which are broccoli, white cabbage, cauliflower, and chinese cabbage.
Acquisition and generation of the data is financially supported in part by CREST/JST.
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.
Glucoraphanin, a natural glucosinolate found in cruciferous vegetable, is a stable precursor of the Nrf2 inducer sulforaphane, which possesses antioxidant, anti-inflammatory, and anti-carcinogenic effects.

同义名列表

13 个代谢物同义名

{[(Z)-(5-methanesulfinyl-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyl}pentylidene)amino]oxy}sulfonic acid; [(Z)-(5-methanesulfinyl-1-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]sulfanyl}pentylidene)amino]oxysulfonic acid; [(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl] 5-methylsulfinyl-N-sulfooxy-pentanimidothioate; beta-D-glucopyranose, 1-thio-, 1-(5-(methylsulfinyl)-N-(sulfooxy)pentanimidate); 4-Methylsulphinylbutyl glucosinolic acid; 4-Methylsulfinylbutyl glucosinolic acid; 4-(Methylsulfinyl)butylglucosinolate; 4-Methylsulphinylbutyl glucosinolate; 4-Methylsulfinylbutyl glucosinolate; Sulforaphane glucosinolate; Glucoraphanin; Glucorafanin; Glucoraphanin



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AHR, BDNF, CASP3, CYP1A1, GFAP, HPGDS, KEAP1, NFE2L2, NQO1, PRKAA2, PVALB
Peripheral membrane protein 2 CYP1A1, CYP1B1
Endoplasmic reticulum membrane 3 CYP1A1, CYP1B1, HMOX1
Nucleus 7 AHR, CASP3, HMOX1, KEAP1, NFE2L2, NQO1, PRKAA2
cytosol 11 AHR, CASP3, GFAP, GLS, GPT, HMOX1, HPGDS, KEAP1, NFE2L2, NQO1, PRKAA2
dendrite 3 BDNF, NQO1, PRKAA2
centrosome 1 NFE2L2
nucleoplasm 7 AHR, CASP3, HMOX1, HPGDS, KEAP1, NFE2L2, PRKAA2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 2 CLDN1, TNF
Cytoplasmic side 1 HMOX1
Multi-pass membrane protein 2 CLDN1, UCP1
Synapse 3 GLS, NQO1, PVALB
cell surface 1 TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 NFE2L2, PRKAA2
mitochondrial inner membrane 2 CYP1A1, UCP1
neuronal cell body 4 CASP3, NQO1, PRKAA2, TNF
synaptic vesicle 1 BDNF
Cytoplasm, cytosol 3 GLS, NFE2L2, NQO1
plasma membrane 3 CLDN1, NFE2L2, TNF
Membrane 6 BDNF, CLDN1, CYP1B1, HMOX1, NQO1, PRKAA2
apical plasma membrane 1 CLDN1
axon 3 BDNF, PRKAA2, PVALB
basolateral plasma membrane 1 CLDN1
extracellular exosome 1 GPT
endoplasmic reticulum 2 HMOX1, KEAP1
extracellular space 5 BDNF, HMOX1, IL10, IL6, TNF
perinuclear region of cytoplasm 2 BDNF, HMOX1
Cell junction, tight junction 1 CLDN1
bicellular tight junction 1 CLDN1
mitochondrion 4 CYP1A1, CYP1B1, GLS, UCP1
protein-containing complex 2 AHR, CLDN1
intracellular membrane-bounded organelle 3 CYP1A1, CYP1B1, HPGDS
Microsome membrane 2 CYP1A1, CYP1B1
postsynaptic density 1 CASP3
Secreted 3 BDNF, IL10, IL6
extracellular region 4 BDNF, IL10, IL6, TNF
mitochondrial outer membrane 1 HMOX1
astrocyte end-foot 1 GFAP
mitochondrial matrix 1 GLS
transcription regulator complex 1 AHR
centriolar satellite 1 KEAP1
external side of plasma membrane 1 TNF
midbody 1 KEAP1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 2 CYP1A1, UCP1
Membrane raft 1 TNF
intermediate filament 1 GFAP
lateral plasma membrane 1 CLDN1
nuclear speck 1 PRKAA2
chromatin 2 AHR, NFE2L2
mediator complex 1 NFE2L2
cell projection 1 GFAP
phagocytic cup 1 TNF
[Isoform 1]: Mitochondrion 1 GLS
actin filament 1 KEAP1
Basolateral cell membrane 1 CLDN1
Cul3-RING ubiquitin ligase complex 1 KEAP1
aryl hydrocarbon receptor complex 1 AHR
cytoplasmic stress granule 1 PRKAA2
cell body 1 GFAP
intermediate filament cytoskeleton 1 GFAP
endoplasmic reticulum lumen 2 BDNF, IL6
tight junction 1 CLDN1
Single-pass type IV membrane protein 1 HMOX1
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
[Isoform 3]: Mitochondrion 1 GLS
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
cytoplasmic side of lysosomal membrane 1 GFAP
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
nuclear aryl hydrocarbon receptor complex 1 AHR
cytosolic aryl hydrocarbon receptor complex 1 AHR
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Hao Zheng, Wenli Huang, Xiangxiang Li, Huanhuan Huang, Qiao Yuan, Ruobin Liu, Hongmei Di, Sha Liang, Mengyu Wang, Mengyao Li, Zhi Huang, Yi Tang, Yangxia Zheng, Huiying Miao, Jie Ma, Huanxiu Li, Qiaomei Wang, Bo Sun, Fen Zhang. CRISPR/Cas9-mediated BoaAOP2s editing alters aliphatic glucosinolate side-chain metabolic flux and increases the glucoraphanin content in Chinese kale. Food research international (Ottawa, Ont.). 2023 08; 170(?):112995. doi: 10.1016/j.foodres.2023.112995. [PMID: 37316021]
  • Jiaying Wu, Weiling Guo, Shumao Cui, Xin Tang, Qiuxiang Zhang, Wenwei Lu, Yan Jin, Jianxin Zhao, Bingyong Mao, Wei Chen. Broccoli seed extract rich in polysaccharides and glucoraphanin ameliorates DSS-induced colitis via intestinal barrier protection and gut microbiota modulation in mice. Journal of the science of food and agriculture. 2023 Mar; 103(4):1749-1760. doi: 10.1002/jsfa.12382. [PMID: 36495024]
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  • Sónia S Ferreira, Filipa Monteiro, Cláudia P Passos, Artur M S Silva, Dulcineia Ferreira Wessel, Manuel A Coimbra, Susana M Cardoso. Blanching impact on pigments, glucosinolates, and phenolics of dehydrated broccoli by-products. Food research international (Ottawa, Ont.). 2020 06; 132(?):109055. doi: 10.1016/j.foodres.2020.109055. [PMID: 32331656]
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