Hypericin (BioDeep_00000000260)

 

Secondary id: BioDeep_00000378733

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs Volatile Flavor Compounds natural product


代谢物信息卡片


5,7,11,18,22,24-HEXAHYDROXY-13,16-DIMETHYLOCTACYCLO[13.11.1.1(2),(1)?.0(3),?.0?,(2)?.0(1)?,(2)?.0(2)(1),(2)?.0(1)?,(2)?]OCTACOSA-1,3,5,7,10,12,14(28),15(27),16,18,21,23,25-TRIDECAENE-9,20-DIONE

化学式: C30H16O8 (504.0845136)
中文名称: 金丝桃蒽酮, 金丝桃素
谱图信息: 最多检出来源 Viridiplantae(plant) 2.88%

分子结构信息

SMILES: CC1=CC(=C2C3=C4C5=C(C(=O)C=C(C5=C2O)O)C6=C7C4=C8C(=C13)C(=CC(=O)C8=C(C7=C(C=C6O)O)O)C)O
InChI: InChI=1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3

描述信息

Hypericin is found in alcoholic beverages. Hypericin is widespread in Hypericum species especially Hypericum perforatum (St Johns Wort) Hypericin is a red-coloured anthraquinone-derivative, which, together with hyperforin, is one of the principal active constituents of Hypericum (Saint Johns wort). Hypericin is believed to act as an antibiotic and non-specific kinase inhibitor. Hypericin may inhibit the action of the enzyme dopamine -hydroxylase, leading to increased dopamine levels, although thus possibly decreasing norepinephrine and epinephrine
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
Widespread in Hypericum subspecies especies Hypericum perforatum (St Johns Wort)
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
C274 - Antineoplastic Agent > C1931 - Antineoplastic Plant Product
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D011838 - Radiation-Sensitizing Agents
D000970 - Antineoplastic Agents
C1907 - Drug, Natural Product
D004791 - Enzyme Inhibitors
Hypericin is a carbopolycyclic compound. It has a role as an antidepressant. It derives from a hydride of a bisanthene.
Hypericin is a natural product found in Hypericum adenotrichum, Hypericum bithynicum, and other organisms with data available.
Hypericin is an anthraquinone derivative that is naturally found in the yellow flower of Hypericum perforatum (St. Johns wort) with antidepressant, potential antiviral, antineoplastic and immunostimulating activities. Hypericin appears to inhibit the neuronal uptake of serotonin, norepinephrine, dopamine, gamma-amino butyric acid (GABA) and L-glutamate, which may contribute to its antidepressant effect. Hypericin may also prevent the replication of encapsulated viruses probably due to inhibition of the assembly and shedding of virus particles in infected cells. This agent also exerts potent phototoxic effects by triggering apoptotic signaling that results in formation of reactive oxygen species.
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis[1][2][3].
Hypericin is a naturally occurring substance found in Hyperlcurn perforatum L. Hypericin is an inhibitor of PKC (protein kinase C), MAO (monoaminoxidase), dopamine-beta-hydroxylase, reverse transcriptase, telomerase and CYP (cytochrome P450). Hypericin shows antitumor, antiviral, antidepressive activities, and can induce apoptosis[1][2][3].

同义名列表

51 个代谢物同义名

5,7,11,18,22,24-hexahydroxy-13,16-dimethyloctacyclo[13.11.1.1²,¹⁰.0³,⁸.0⁴,²⁵.0¹⁹,²⁷.0²¹,²⁶.0¹⁴,²⁸]octacosa-1(27),2(28),3,5,7,10,12,14,16,18,21,23,25-tridecaene-9,20-dione; 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione P-conformer; 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione, 9CI; 1:6:8:10:11:13-hexahydroxy-3:4-dimethyl-meso-naphthodianthrene-7:14-dione; 4,5,7,4,5,7-Hexahydroxy-2,2-dimethylnaphthodianthrone; Hypericin from Hypericum perforatum; Hypericin & Visible light; mono-(123I)iodohypericin; Hypericum extract; Mycoporphyrin; hypericum red; hipericina; hypericine; Hyperizin; Hypericin; VIMRxyn; 5,7,11,18,22,24-HEXAHYDROXY-13,16-DIMETHYLOCTACYCLO[13.11.1.1(2),(1)?.0(3),?.0?,(2)?.0(1)?,(2)?.0(2)(1),(2)?.0(1)?,(2)?]OCTACOSA-1,3,5,7,10,12,14(28),15(27),16,18,21,23,25-TRIDECAENE-9,20-DIONE; 9,11,13,16,18,20-hexahydroxy-5,24-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(26),2,4(25),5,8,10,12,14(28),15(27),16,18,20,23-tridecaene-7,22-dione; 5,7,11,18,22,24-hexahydroxy-13,16-dimethyloctacyclo[13.11.1.12,10.03,8.04,25.019,27.021,26.014,28]octacosa-1(27),2(28),3,5,7,10,12,14,16,18,21,23,25-tridecaene-9,20-dione; InChI=1/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H; rac-(3aM,10aM)-1,3,4,6,8,13-hexahydroxy-10,11- dimethylphenanthro[1,10,9,8-opqra]perylene-7,14- dione; Phenanthro[1,10,9,8-opqra]perylene-7,14-dione,1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-, stereoisomer; Phenanthro[1,9,8-opqra]perylene-7,14-dione,1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-, stereoisomer; 1,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro [1,10,9,8-opqra]perylene-7,14-dione P-conformer; Phenanthro(1,10,9,8-opqra)perylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-; Phenanthro[1,10,9,8-opqra]perylene-7,14-dione, 1,3,4,6,8,13-hexahydroxy-10,11-dimethyl-; 1,3,4,6,8,13-hexahydroxy-10,11-dimethylphenanthro(1,10,9,8-opqra)perylene-7,14-dione; 1,3,4,6,8,13-Hexahydroxy-10,11-dimethylphenanthro[1,10,9,8-opqra]perylene-7,14-dione; Hypericin is known as an anthroquinone derivative found in St. Johns Wort.; 4,5,7,4,5,7-Hexahydroxy-2,2-dimethyl-mesonapthtodianthron; Hypericin, primary pharmaceutical reference standard; Hypericin from Hypericum perforatum, ~95\\% (HPLC); (component of) Hypericum spp (st. Johns wort); hexahydroxy(dimethyl)[?]dione; BTXNYTINYBABQR-UHFFFAOYSA-N; HYPERICIN [WHO-DD]; Hypericin [USAN]; BiomolKI2_000040; hypericin [INN]; UNII-7V2F1075HD; NCI60_003879; HSCI1_000202; NCI60_006799; Cyclo werro; Cyclo-Werol; 7V2F1075HD; hipericin; Cyclosan; C30H16O8; BMK1-D8; Hypericin



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

211 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xin Liu, Xiao-Ying He, Bo-Long Liu, Ping-Shun Song. [Determination of 13 chemical components of Epimedii Folium in pharmacopoeia by UPLC method combined with quantitative analysis of multicomponents by single-marker]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Feb; 49(4):981-988. doi: 10.19540/j.cnki.cjcmm.20231115.103. [PMID: 38621905]
  • Hongxiao Xie, Zhiqiang Xie, Fei Luan, Jiuseng Zeng, Xiumeng Zhang, Li Chen, Nan Zeng, Rong Liu. Potential therapeutic effects of Chinese herbal medicine in postpartum depression: Mechanisms and future directions. Journal of ethnopharmacology. 2024 Jan; 324(?):117785. doi: 10.1016/j.jep.2024.117785. [PMID: 38262525]
  • Vanessa Fabienne Abegg, Miljenko Valentin Panajatovic, Riccardo Vincenzo Mancuso, Julien Arthur Allard, Urs Duthaler, Alex Odermatt, Stephan Krähenbühl, Jamal Bouitbir. Mechanisms of hepatocellular toxicity associated with the components of St. John's Wort extract hypericin and hyperforin in HepG2 and HepaRG cells. Toxicology letters. 2024 Jan; 393(?):1-13. doi: 10.1016/j.toxlet.2024.01.008. [PMID: 38219807]
  • Viktória Pevná, Ľuboš Zauška, Anass Benziane, György Vámosi, Vladimír Girman, Monika Miklóšová, Vladimír Zeleňák, Veronika Huntošová, Miroslav Almáši. Effective transport of aggregated hypericin encapsulated in SBA-15 nanoporous silica particles for photodynamic therapy of cancer cells. Journal of photochemistry and photobiology. B, Biology. 2023 Oct; 247(?):112785. doi: 10.1016/j.jphotobiol.2023.112785. [PMID: 37714000]
  • Martyna Nowak-Perlak, Piotr Ziółkowski, Marta Woźniak. A promising natural anthraquinones mediated by photodynamic therapy for anti-cancer therapy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Oct; 119(?):155035. doi: 10.1016/j.phymed.2023.155035. [PMID: 37603973]
  • Zhaolei Peng, Jing Lu, Kai Liu, Long Xie, Yulin Wang, Chunyan Cai, Dejun Yang, Jingjing Xi, Chunmei Yan, Xiaofang Li, Mingyi Shi. Hypericin as a promising natural bioactive naphthodianthrone: A review of its pharmacology, pharmacokinetics, toxicity, and safety. Phytotherapy research : PTR. 2023 Sep; ?(?):. doi: 10.1002/ptr.8011. [PMID: 37690821]
  • Patricia Rocha de Araújo, Mariana Rillo Sato, Marcela Tavares Luiz, Marlus Chorilli. Validation of an innovative chromatographic method for hypericin quantification in nanostructured lipid carriers. Journal of AOAC International. 2023 Sep; ?(?):. doi: 10.1093/jaoacint/qsad100. [PMID: 37672013]
  • Flávia Amanda Pedroso de Morais, Rodolfo Bento Balbinot, Amanda Beatriz Kawano Bakoshi, Danielle Lazarin-Bidoia, Katieli da Silva Souza Campanholi, Ranulfo Combuca da Silva Junior, Renato Sonchini Gonçalves, Tânia Ueda-Nakamura, Sueli de Oliveira Silva, Wilker Caetano, Celso Vataru Nakamura. Advanced theranostic nanoplatforms for hypericin delivery in the cancer treatment. Journal of photochemistry and photobiology. B, Biology. 2023 Sep; 247(?):112782. doi: 10.1016/j.jphotobiol.2023.112782. [PMID: 37660488]
  • Viktória Pevná, Ľuboš Zauška, Miroslav Almáši, Andrej Hovan, Gregor Bánó, Mariana Máčajová, Boris Bilčík, Vladimír Zeleňák, Veronika Huntošová. Redistribution of hydrophobic hypericin from nanoporous particles of SBA-15 silica in vitro, in cells and in vivo. International journal of pharmaceutics. 2023 Jul; 643(?):123288. doi: 10.1016/j.ijpharm.2023.123288. [PMID: 37532008]
  • Moritz Winker, Antoine Chauveau, Martin Smieško, Olivier Potterat, Alexander Areesanan, Amy Zimmermann-Klemd, Carsten Gründemann. Immunological evaluation of herbal extracts commonly used for treatment of mental diseases during pregnancy. Scientific reports. 2023 Jun; 13(1):9630. doi: 10.1038/s41598-023-35952-5. [PMID: 37316493]
  • Chunguang Lei, Ningning Li, Jianhua Chen, Qingzhong Wang. Hypericin Ameliorates Depression-like Behaviors via Neurotrophin Signaling Pathway Mediating m6A Epitranscriptome Modification. Molecules (Basel, Switzerland). 2023 May; 28(9):. doi: 10.3390/molecules28093859. [PMID: 37175269]
  • Antoine Chauveau, Andrea Treyer, Annelies Geirnaert, Lea Bircher, Angela Babst, Vanessa Fabienne Abegg, Ana Paula Simões-Wüst, Christophe Lacroix, Olivier Potterat, Matthias Hamburger. Intestinal permeability and gut microbiota interactions of pharmacologically active compounds in valerian and St. John's wort. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Apr; 162(?):114652. doi: 10.1016/j.biopha.2023.114652. [PMID: 37027987]
  • Camila Barros Galinari, Tiago de Paula Biachi, Renato Sonchini Gonçalves, Gabriel Batista Cesar, Eduardo Victor Bergmann, Luis Carlos Malacarne, Érika Seki Kioshima Cotica, Patrícia de Souza Bonfim-Mendonça, Terezinha Inez Estivalet Svidzinski. Photoactivity of hypericin: from natural product to antifungal application. Critical reviews in microbiology. 2023 Feb; 49(1):38-56. doi: 10.1080/1040841x.2022.2036100. [PMID: 35171731]
  • Ane Sager Longva, Kristian Berg, Anette Weyergang. Light-enhanced VEGF121/rGel induce immunogenic cell death and increase the antitumor activity of αCTLA4 treatment. Frontiers in immunology. 2023; 14(?):1278000. doi: 10.3389/fimmu.2023.1278000. [PMID: 38173721]
  • Shuping Yang, Junting Ma, Tian Li, Peng Wang, Xudan Wang, Jian Zhang, Yicheng Ni, Haibo Shao. Radioiodinated hypericin as a tracer for detection of acute myocardial infarction: SPECT-CT imaging in a swine model. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. 2022 12; 29(6):3432-3439. doi: 10.1007/s12350-022-02933-6. [PMID: 35296972]
  • Mariana Rillo Sato, João Augusto Oshiro-Junior, Camila Fernanda Rodero, Fernanda Isadora Boni, Victor Hugo Sousa Araújo, Taís Maria Bauab, Dean Nicholas, John F Callan, Marlus Chorilli. Photodynamic therapy-mediated hypericin-loaded nanostructured lipid carriers against vulvovaginal candidiasis. Journal de mycologie medicale. 2022 Nov; 32(4):101296. doi: 10.1016/j.mycmed.2022.101296. [PMID: 35660541]
  • Kang Cao, Yan Zhang, Qian Yao, Yanjuan Peng, Qu Pan, Qiuxia Jiao, Ke Ren, Fenghui Sun, Qian Zhang, Ran Guo, Jiali Zhang, Tian Chen. Hypericin blocks the function of HSV-1 alkaline nuclease and suppresses viral replication. Journal of ethnopharmacology. 2022 Oct; 296(?):115524. doi: 10.1016/j.jep.2022.115524. [PMID: 35811028]
  • Heba Abd-El-Azim, Ismaiel A Tekko, Ahlam Ali, Alyaa Ramadan, Noha Nafee, Nawal Khalafallah, Taifur Rahman, William Mcdaid, Rania G Aly, Lalitkumar K Vora, Steven J Bell, Fiona Furlong, Helen O McCarthy, Ryan F Donnelly. Hollow microneedle assisted intradermal delivery of hypericin lipid nanocapsules with light enabled photodynamic therapy against skin cancer. Journal of controlled release : official journal of the Controlled Release Society. 2022 08; 348(?):849-869. doi: 10.1016/j.jconrel.2022.06.027. [PMID: 35728715]
  • Dharmendra Kashyap, Rajarshi Roy, Parimal Kar, Hem Chandra Jha. Plant-derived active compounds as a potential nucleocapsid protein inhibitor of SARS-CoV-2: an in-silico study. Journal of biomolecular structure & dynamics. 2022 May; ?(?):1-16. doi: 10.1080/07391102.2022.2072951. [PMID: 35532092]
  • Larissa Mendes de Souza, Fernanda Diniz de Sousa, Roberta Cristina Ribeiro Cruz, Denise Crispim Tavares, Pollyanna Francielli de Oliveira. Hypericin, a medicinal compound from St. John's Wort, inhibits genotoxicity induced by mutagenic agents in V79 cells. Drug and chemical toxicology. 2022 May; 45(3):1302-1307. doi: 10.1080/01480545.2020.1822389. [PMID: 33050761]
  • Xuejia Zhai, Yan Chen, Xuemei Han, Ying Zhu, Xixuan Li, Yu Zhang, Yongning Lu. The protective effect of hypericin on postpartum depression rat model by inhibiting the NLRP3 inflammasome activation and regulating glucocorticoid metabolism. International immunopharmacology. 2022 Apr; 105(?):108560. doi: 10.1016/j.intimp.2022.108560. [PMID: 35101848]
  • Esra Saçıcı, Erdem Yesilada. Development of new and validated HPTLC methods for the qualitative and quantitative analysis of hyperforin, hypericin and hyperoside contents in Hypericum species. Phytochemical analysis : PCA. 2022 Apr; 33(3):355-364. doi: 10.1002/pca.3093. [PMID: 34734668]
  • Mojtaba Khaksarian, Mahmoud Bahmani, Morovat Taherikalani, Behnam Ashrafi, Mahmoud Rafieian-Kopaei, Naser Abbasi. Biosynthesis of titanium dioxide nanoparticles using Hypericum perforatum and Origanum vulgare extracts and their main components, hypericin and carvacrol as promising antibacterial agents. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 04; 42(2):167-175. doi: 10.19852/j.cnki.jtcm.2022.02.002. [PMID: 35473336]
  • Pietro Delcanale, Eleonora Uriati, Matteo Mariangeli, Andrea Mussini, Ana Moreno, Davide Lelli, Luigi Cavanna, Paolo Bianchini, Alberto Diaspro, Stefania Abbruzzetti, Cristiano Viappiani. The Interaction of Hypericin with SARS-CoV-2 Reveals a Multimodal Antiviral Activity. ACS applied materials & interfaces. 2022 Mar; 14(12):14025-14032. doi: 10.1021/acsami.1c22439. [PMID: 35302731]
  • Yang Sun, Chen Liang, Lihua Zheng, Lei Liu, Zhijin Li, Guang Yang, Yuxin Li. Anti-fatigue effect of hypericin in a chronic forced exercise mouse model. Journal of ethnopharmacology. 2022 Feb; 284(?):114767. doi: 10.1016/j.jep.2021.114767. [PMID: 34710555]
  • Dalong Wang, Tingting Zhao, Shan Zhao, Jing Chen, Tongyi Dou, Guangbo Ge, Changyuan Wang, Huijun Sun, Kexin Liu, Qiang Meng, Jingjing Wu. Substrate-dependent Inhibition of Hypericin on Human Carboxylesterase 2: Implications for Herb-drug Combination. Current drug metabolism. 2022; 23(1):38-44. doi: 10.2174/1389200223666220202093303. [PMID: 35114918]
  • Borivoj Adnadjevic, Biljana Koturevic, Jelena Jovanovic. Isothermal kinetics of ethanolic extraction of total hypericin from pre-extracted Hypericum perforatum flowers. Phytochemical analysis : PCA. 2021 Sep; 32(5):757-766. doi: 10.1002/pca.3021. [PMID: 33319396]
  • Oksana Sytar, Konstantia Kotta, Dimitrios Valasiadis, Anatoliy Kosyan, Marian Brestic, Venetia Koidou, Eleftheria Papadopoulou, Maria Kroustalaki, Christina Emmanouilidou, Alexandros Pashalidis, Ilias Avdikos, Zoe Hilioti. The Effects of Photosensitizing Dyes Fagopyrin and Hypericin on Planktonic Growth and Multicellular Life in Budding Yeast. Molecules (Basel, Switzerland). 2021 Aug; 26(16):. doi: 10.3390/molecules26164708. [PMID: 34443298]
  • Eleni Pitsillou, Julia Liang, Katherine Ververis, Andrew Hung, Tom C Karagiannis. Interaction of small molecules with the SARS-CoV-2 papain-like protease: In silico studies and in vitro validation of protease activity inhibition using an enzymatic inhibition assay. Journal of molecular graphics & modelling. 2021 05; 104(?):107851. doi: 10.1016/j.jmgm.2021.107851. [PMID: 33556646]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Yue Li, Shuncong Wang, Xiao Jiang, Xiaoxiong Wang, Xiang Zhou, Liangrong Wan, Haitao Zhao, Zhaoli Zhou, LingJie Gao, Gang Huang, Yicheng Ni, Xiaoyan He. Preparation and validation of cyclodextrin-based excipients for radioiodinated hypericin applied in a targeted cancer radiotherapy. International journal of pharmaceutics. 2021 Apr; 599(?):120393. doi: 10.1016/j.ijpharm.2021.120393. [PMID: 33639227]
  • Hongyan Su, Jie Li, Sijin Chen, Ping Sun, Hua Xing, Delong Yang, Xiaona Zhang, Mengfei Li, Jianhe Wei. Physiological and Transcriptomic Analysis Provide Insight into Low Temperature Enhancing Hypericin Biosynthesis in Hypericum perforatum. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082294. [PMID: 33921038]
  • Xiaoxv Dong, Yawen Zeng, Zhiqin Zhang, Jing Fu, Longtai You, Yuanyuan He, Yang Hao, Zili Gu, Zhenfeng Yu, Changhai Qu, Xingbin Yin, Jian Ni, Luis J Cruz. Hypericin-mediated photodynamic therapy for the treatment of cancer: a review. The Journal of pharmacy and pharmacology. 2021 Mar; 73(4):425-436. doi: 10.1093/jpp/rgaa018. [PMID: 33793828]
  • Flávia Amanda Pedroso de Morais, Renato Sonchini Gonçalves, Katieli Souza Campanholi, Bruna Martins de França, Otávio Augusto Capeloto, Danielle Lazarin-Bidoia, Rodolfo Bento Balbinot, Celso Vataru Nakamura, Luis Carlos Malacarne, Wilker Caetano, Noboru Hioka. Photophysical characterization of Hypericin-loaded in micellar, liposomal and copolymer-lipid nanostructures based F127 and DPPC liposomes. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Mar; 248(?):119173. doi: 10.1016/j.saa.2020.119173. [PMID: 33316657]
  • Katerina Makarova, Joanna J Sajkowska-Kozielewicz, Katarzyna Zawada, Ewa Olchowik-Grabarek, Michał Aleksander Ciach, Krzysztof Gogolewski, Natalia Dobros, Paulina Ciechowicz, Hélène Freichels, Anna Gambin. Harvest time affects antioxidant capacity, total polyphenol and flavonoid content of Polish St John's wort's (Hypericum perforatum L.) flowers. Scientific reports. 2021 02; 11(1):3989. doi: 10.1038/s41598-021-83409-4. [PMID: 33597594]
  • S Jafarirad, M Kosari-Nasab, R Mohammadpour Tavana, S Mahjouri, R Ebadollahi. Impacts of manganese bio-based nanocomposites on phytochemical classification, growth and physiological responses of Hypericum perforatum L. shoot cultures. Ecotoxicology and environmental safety. 2021 Feb; 209(?):111841. doi: 10.1016/j.ecoenv.2020.111841. [PMID: 33387772]
  • Hamid Zaferani Arani, Maedeh Olya, Asra Sadat Mirahmadi, Hossein Saleki, Hesam Adin Atashi, Hadi Zare Marzouni, Mohammad Hoseinian, Mohammad Amin Javidi, Amirhossein Zabolian. Hypericin induces apoptosis in K562 cells via downregulation of Myc and Mdm2. Journal of cancer research and therapeutics. 2021 Jan; 17(1):242-247. doi: 10.4103/jcrt.jcrt_826_19. [PMID: 33723162]
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