2,4-Dinitrophenol (BioDeep_00000002396)

 

Secondary id: BioDeep_00001867689

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


1-Hydroxy-2,4-dinitrobenzene

化学式: C6H4N2O5 (184.01202139999998)
中文名称: 2,4-二硝基酚, 硫化黑 1
谱图信息: 最多检出来源 Homo sapiens(blood) 0.18%

分子结构信息

SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])O
InChI: InChI=1S/C6H4N2O5/c9-6-2-1-4(7(10)11)3-5(6)8(12)13/h1-3,9H

描述信息

CONFIDENCE standard compound; INTERNAL_ID 447; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3673; ORIGINAL_PRECURSOR_SCAN_NO 3671
CONFIDENCE standard compound; INTERNAL_ID 447; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3652; ORIGINAL_PRECURSOR_SCAN_NO 3650
CONFIDENCE standard compound; INTERNAL_ID 447; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3645; ORIGINAL_PRECURSOR_SCAN_NO 3640
CONFIDENCE standard compound; INTERNAL_ID 447; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3674; ORIGINAL_PRECURSOR_SCAN_NO 3673
CONFIDENCE standard compound; INTERNAL_ID 447; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3657; ORIGINAL_PRECURSOR_SCAN_NO 3655
CONFIDENCE standard compound; INTERNAL_ID 447; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3632; ORIGINAL_PRECURSOR_SCAN_NO 3630
D010575 - Pesticides > D005659 - Fungicides, Industrial > D004140 - Dinitrophenols
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 8070
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 8823
D004791 - Enzyme Inhibitors > D014475 - Uncoupling Agents
CONFIDENCE standard compound; INTERNAL_ID 2302
D004396 - Coloring Agents
KEIO_ID D097

同义名列表

8 个代谢物同义名

1-Hydroxy-2,4-dinitrobenzene; alpha-Dinitrophenol; 2,4-dinitrophenol; 2,4 Dinitrophenol; a-Dinitrophenol; Α-dinitrophenol; Sulphur Black 1; 2,4-DNP



数据库引用编号

33 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Kristina Žuna, Tatyana Tyschuk, Taraneh Beikbaghban, Felix Sternberg, Jürgen Kreiter, Elena E Pohl. The 2-oxoglutarate/malate carrier extends the family of mitochondrial carriers capable of fatty acid and 2,4-dinitrophenol-activated proton transport. Acta physiologica (Oxford, England). 2024 Jun; 240(6):e14143. doi: 10.1111/apha.14143. [PMID: 38577966]
  • Lyndsey F Meyer, Pooja M Rajadhyaksha, Dhaval K Shah. Physiologically-based pharmacokinetic model for 2,4-dinitrophenol. Journal of pharmacokinetics and pharmacodynamics. 2022 06; 49(3):325-336. doi: 10.1007/s10928-022-09806-y. [PMID: 35089483]
  • Kristina Žuna, Olga Jovanović, Ljudmila S Khailova, Sanja Škulj, Zlatko Brkljača, Jürgen Kreiter, Elena A Kotova, Mario Vazdar, Yuri N Antonenko, Elena E Pohl. Mitochondrial Uncoupling Proteins (UCP1-UCP3) and Adenine Nucleotide Translocase (ANT1) Enhance the Protonophoric Action of 2,4-Dinitrophenol in Mitochondria and Planar Bilayer Membranes. Biomolecules. 2021 08; 11(8):. doi: 10.3390/biom11081178. [PMID: 34439844]
  • Xiao-Rong Xu, Jin-Fa Tang, Hui Zhang, Fei Ran, Wei Liao, Fang Wang, Xiang-Bo Yang, Jun-Zhi Lin, Ming Yang, Ding-Kun Zhang, Li Han. [Antipyretic activity and potential mechanism of Indigo Naturalis on 2,4-dinitrophenol-induced fever rat model]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2021 Jul; 46(13):3205-3212. doi: 10.19540/j.cnki.cjcmm.20210323.301. [PMID: 34396738]
  • A Griffiths, N Milne, B Ong, T Watkins. 2,4-Dinitrophenol overdose - Everything old is new again. Journal of forensic and legal medicine. 2021 Apr; 79(?):102148. doi: 10.1016/j.jflm.2021.102148. [PMID: 33706128]
  • Jin Il Kwak, Shin Woong Kim, Lia Kim, Rongxue Cui, Jieun Lee, Dokyung Kim, Yooeun Chae, Youn-Joo An. Determination of hazardous concentrations of 2,4-dinitrophenol in freshwater ecosystems based on species sensitivity distributions. Aquatic toxicology (Amsterdam, Netherlands). 2020 Nov; 228(?):105646. doi: 10.1016/j.aquatox.2020.105646. [PMID: 33011648]
  • Ljudmila S Khailova, Tatyana V Vygodina, Galina Y Lomakina, Elena A Kotova, Yuri N Antonenko. Bicarbonate suppresses mitochondrial membrane depolarization induced by conventional uncouplers. Biochemical and biophysical research communications. 2020 09; 530(1):29-34. doi: 10.1016/j.bbrc.2020.06.131. [PMID: 32828301]
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  • Eduardo Geraldo de Campos, Melissa Fogarty, Bruno Spinosa De Martinis, Barry Kerr Logan. Analysis of 2,4-Dinitrophenol in Postmortem Blood and Urine by Gas Chromatography-Mass Spectrometry: Method Development and Validation and Report of Three Fatalities in the United States. Journal of forensic sciences. 2020 Jan; 65(1):183-188. doi: 10.1111/1556-4029.14154. [PMID: 31430392]
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  • Jiu Kun Jiang, Wen Fang, Lin Hui Gu, Yuan Qiang Lu. Early Changes of Peripheral Blood Lymphocyte Subpopulations in Patients with Occupational 2,4-dinitrophenol Poisoning. Biomedical and environmental sciences : BES. 2016 Dec; 29(12):909-914. doi: 10.3967/bes2016.122. [PMID: 28081753]
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  • Xue-hong Zhao, Jiu-kun Jiang, Yuan-qiang Lu. Evaluation of efficacy of resin hemoperfusion in patients with acute 2,4-dinitrophenol poisoning by dynamic monitoring of plasma toxin concentration. Journal of Zhejiang University. Science. B. 2015 Aug; 16(8):720-6. doi: 10.1631/jzus.b1500101. [PMID: 26238547]
  • Darya V Pyatrikas, Irina V Fedoseeva, Nina N Varakina, Tatyana M Rusaleva, Alexei V Stepanov, Anna V Fedyaeva, Gennadii B Borovskii, Eugene G Rikhvanov. Relation between cell death progression, reactive oxygen species production and mitochondrial membrane potential in fermenting Saccharomyces cerevisiae cells under heat-shock conditions. FEMS microbiology letters. 2015 Jun; 362(12):fnv082. doi: 10.1093/femsle/fnv082. [PMID: 25991811]
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  • Chien-Hsun Chen, Tsung-Chi Chen, Xiaoyu Zhou, Robert Kline-Schoder, Paul Sorensen, R Graham Cooks, Zheng Ouyang. Design of portable mass spectrometers with handheld probes: aspects of the sampling and miniature pumping systems. Journal of the American Society for Mass Spectrometry. 2015 Feb; 26(2):240-7. doi: 10.1007/s13361-014-1026-5. [PMID: 25404157]
  • Nancy Hachicho, Sarah Reithel, Anja Miltner, Hermann J Heipieper, Eberhard Küster, Till Luckenbach. Body Mass Parameters, Lipid Profiles and Protein Contents of Zebrafish Embryos and Effects of 2,4-Dinitrophenol Exposure. PloS one. 2015; 10(8):e0134755. doi: 10.1371/journal.pone.0134755. [PMID: 26292096]
  • Mahboobeh Zolfagharzadeh, Maliheh Pirouzi, Ahmad Asoodeh, Mohammad Reza Saberi, Jamshidkhan Chamani. A comparison investigation of DNP-binding effects to HSA and HTF by spectroscopic and molecular modeling techniques. Journal of biomolecular structure & dynamics. 2014 Dec; 32(12):1936-52. doi: 10.1080/07391102.2013.843062. [PMID: 24125112]
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  • Lianhe Zhang, Bin Hu, Wei Li, Ronghui Che, Kun Deng, Hua Li, Feiyan Yu, Hongqing Ling, Youjun Li, Chengcai Chu. OsPT2, a phosphate transporter, is involved in the active uptake of selenite in rice. The New phytologist. 2014 Mar; 201(4):1183-1191. doi: 10.1111/nph.12596. [PMID: 24491113]
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  • Yong-chun He, Ping Zhang, Chun-ping Xu, Hui-juan Yan, Yuan-qiang Lu, Zeng-xuan Cai, Jiang-hua Chen. [Effects of hemoperfusion on the patients with acute toxication of 2, 4-dinitrophenol]. Zhonghua yi xue za zhi. 2013 Sep; 93(34):2742-4. doi: NULL. [PMID: 24360112]
  • Ella Meltzer-Mats, Gali Babai-Shani, Lily Pasternak, Neta Uritsky, Tamar Getter, Olga Viskind, Jürgen Eckel, Erol Cerasi, Hanoch Senderowitz, Shlomo Sasson, Arie Gruzman. Synthesis and mechanism of hypoglycemic activity of benzothiazole derivatives. Journal of medicinal chemistry. 2013 Jul; 56(13):5335-50. doi: 10.1021/jm4001488. [PMID: 23750537]
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