Monocrotaline (BioDeep_00000229961)

Main id: BioDeep_00000002079

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


2H-(1,6)DIOXACYCLOUNDECINO(2,3,4-GH)PYRROLIZINE-2,6(3H)-DIONE, 4,5,8,10,12,13,13A,13B-OCTAHYDRO-4,5-DIHYDROXY-3,4,5-TRIMETHYL-, (3R-(3R*,4R*,5R*,13AR*,13BR*))-

化学式: C16H23NO6 (325.1525298)
中文名称: 单响尾蛇毒蛋白, 大叶猪尿青碱, 农吉利甲素, 猪屎豆碱, 野百合碱, 农吉利碱
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(=O)OC2CCN3C2C(=CC3)COC(=O)C(C1(C)O)(C)O
InChI: InChI=1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3/t9-,11+,12+,15+,16-/m0/s1

描述信息

Monocrotaline is a pyrrolizidine alkaloid.
Monocrotaline is a natural product found in Crotalaria novae-hollandiae, Crotalaria recta, and other organisms with data available.
A pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hypertension, right ventricular hypertrophy, and pathological changes in the pulmonary vasculature. Significant attenuation of the cardiopulmonary changes are noted after oral magnesium treatment.
Origin: Plant; SubCategory_DNP: Alkaloids derived from ornithine, Pyrrolizidine alkaloids
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.154
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.142
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.145
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 μM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 μM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].

同义名列表

53 个代谢物同义名

2H-(1,6)DIOXACYCLOUNDECINO(2,3,4-GH)PYRROLIZINE-2,6(3H)-DIONE, 4,5,8,10,12,13,13A,13B-OCTAHYDRO-4,5-DIHYDROXY-3,4,5-TRIMETHYL-, (3R-(3R*,4R*,5R*,13AR*,13BR*))-; 2H-(1,6)Dioxacycloundecino(2,3,4-gh)pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13aR,13bR)-; 2H-[1,6]Dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione, 4,5,8,10,12,13,13a,13b-octahydro-4,5-dihydroxy-3,4,5-trimethyl-, (3R,4R,5R,13aR,13bR)-; rel-(3R,4R,5R,8a1R,13aR)-4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,8a1,10,12,13,13a-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione; (3R,4R,5R,8a1R,13aR)-4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,8a1,10,12,13,13a-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione; (3R,4R,5R,13aR,13bR)-4,5-dihydroxy-3,4,5-trimethyl-4,5,8,10,12,13,13a,13b-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione; (3R,4R,8a1R,13aR)-4,5-Dihydroxy-3,4,5-trimethyl-4,5,8,8a1,10,12,13,13a-octahydro-2H-[1,6]dioxacycloundecino[2,3,4-gh]pyrrolizine-2,6(3H)-dione; (2,3,4-gh)pyrrolizine-2,6(3H)-dione, (4,5,8,10,12,13,13a,13b)-octahydro-4,5-dihydroxy-3,4,5-trimethyl-2H-(1,6)dioxacycloundecino-; (1R,4R,5R,6R,16R)-5,6-dihydroxy-4,5,6-trimethyl-2,8-dioxa-13-azatricyclo[8.5.1.0??,??]hexadec-10-ene-3,7-dione; (1R,4R,5R,6R,16R)-5,6-dihydroxy-4,5,6-trimethyl-2,8-dioxa-13-azatricyclo[8.5.1.013,16]hexadec-10-ene-3,7-dione; 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13-alpha,14-alpha)-; 20-Norcrotalanan-11,15-dione, 14,19-dihydro-12,13-dihydroxy-, (13alpha,14alpha)-; (13-alpha,14-alpha)-14,19-Dihydro-12,13-dihydroxy-20-norcrotalanan-11,15-dione; 14,19-Dihydro-12,13-dihydroxy(13-alpha,14-alpha)-20-norcrotalanan-11,15-dione; 12-beta,13-beta-Dihydroxy-12-alpha,13-alpha,14-alpha-trimethylcrotal-1-enine; 14,19-Dihydro-12,13-dihydroxy-20-norcrotolanan-11,15-dione; Retronecine cyclic 2,3-dihydroxy-2,3,4-trimethylglutarate; Monocrotaline Hydrochloride (13alpha,14alpha)-Isomer; 4-27-00-06660 (Beilstein Handbook Reference); Monocrotaline, analytical standard; Monocrotaline, (all-xi)-Isomer; MONOCROTALINE [IARC]; MONOCROTALINE [HSDB]; JACS 72: 158 (1950); MONOCROTALINE [MI]; (-)-Monocrotaline; Prestwick3_000603; Prestwick1_000603; Prestwick2_000603; Prestwick0_000603; Spectrum5_001233; Spectrum3_000947; Spectrum2_000906; Spectrum4_001057; Tox21_112094_1; MEGxp0_001899; Monocrotaline; BPBio1_000558; DivK1c_000959; Tox21_201509; ACon0_000305; Tox21_302874; ACon1_000179; KBio3_002014; KBio2_006840; KBio1_000959; Monocrotalin; KBio2_004272; Tox21_112094; KBio2_001704; IDI1_000959; Crotaline; 1ST14173



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

41 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dufang Ma, Yiwei Qu, Tao Wu, Xue Liu, Lu Cai, Yong Wang. Excessive fat expenditure in MCT-induced heart failure rats is associated with BMAL1/REV-ERBα circadian rhythmic loop disruption. Scientific reports. 2024 04; 14(1):8128. doi: 10.1038/s41598-024-58577-8. [PMID: 38584196]
  • Cristina Campos Carraro, Patrick Turck, Alan Bahr, Luiza Donatti, Giana Corssac, Denise Lacerda, Alex Sander da Rosa Araujo, Alexandre Luz de Castro, Letícia Koester, Adriane Belló-Klein. Effect of free and nanoemulsified β-caryophyllene on monocrotaline-induced pulmonary arterial hypertension. Biochimica et biophysica acta. Molecular cell research. 2024 Apr; 1871(4):119704. doi: 10.1016/j.bbamcr.2024.119704. [PMID: 38462075]
  • Zhenlin Huang, Zeqi Wu, Jingnan Zhang, Keke Wang, Qing Zhao, Minwei Chen, Shihao Yan, Qian Guo, Yun Ma, Lili Ji. Andrographolide attenuated MCT-induced HSOS via regulating NRF2-initiated mitochondrial biogenesis and antioxidant response. Cell biology and toxicology. 2023 Oct; ?(?):. doi: 10.1007/s10565-023-09832-7. [PMID: 37816928]
  • Yueyang Pan, Jiang Ma, Hui Zhao, Peter P Fu, Ge Lin. Hepatotoxicity screening and ranking of structurally different pyrrolizidine alkaloids in zebrafish. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 Jun; 178(?):113903. doi: 10.1016/j.fct.2023.113903. [PMID: 37390955]
  • Qianqian Zhang, Yuqian Chen, Qingting Wang, Yan Wang, Wei Feng, Limin Chai, Jin Liu, Danyang Li, Huan Chen, Yuanjie Qiu, Nirui Shen, Xiangyu Shi, Xinming Xie, Manxiang Li. HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo. Respiratory research. 2023 Jun; 24(1):149. doi: 10.1186/s12931-023-02454-x. [PMID: 37268944]
  • Min Liu, Huixiang He, Fenling Fan, Lejia Qiu, Feng Zheng, Youfei Guan, Guangrui Yang, Lihong Chen. Maresin-1 protects against pulmonary arterial hypertension by improving mitochondrial homeostasis through ALXR/HSP90α axis. Journal of molecular and cellular cardiology. 2023 May; 181(?):15-30. doi: 10.1016/j.yjmcc.2023.05.005. [PMID: 37244057]
  • Qiuxiao Ma, Min Wang, Lanfang Li, Xinyu Zhang, Lixin Cui, Junyu Mou, Guibo Sun, Qiong Zhang. Jiedu Quyu Decoction mitigates monocrotaline-induced right-sided heart failure associated with pulmonary artery hypertension by inhibiting NLRP3 inflammasome in rats. Journal of ethnopharmacology. 2023 May; ?(?):116556. doi: 10.1016/j.jep.2023.116556. [PMID: 37142147]
  • Zhifeng Xue, Mengen Zhou, Yiman Liu, Honglin Qin, Yixuan Li, Yan Zhu, Jian Yang. A modified Fangji Huangqi decoction ameliorates pulmonary artery hypertension via phosphatidylinositide 3-kinases/protein kinase B-mediated regulation of proliferation and apoptosis of smooth muscle cells in vitro and in vivo. Journal of ethnopharmacology. 2023 Apr; ?(?):116544. doi: 10.1016/j.jep.2023.116544. [PMID: 37088239]
  • Anna Krzyżewska, Marta Baranowska-Kuczko, Irena Kasacka, Hanna Kozłowska. Cannabidiol inhibits lung proliferation in monocrotaline-induced pulmonary hypertension in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 159(?):114234. doi: 10.1016/j.biopha.2023.114234. [PMID: 36634588]
  • Adriana L Silva, Joana L Oliveira, Ravena P do Nascimento, Letícia O Santos, Fillipe M de Araújo, Balbino L Dos Santos, Rejane C Santana, Eduardo Luiz T Moreira, Maria José M Batatinha, Iura M Alves, Eudes S Velozo, Mauricio M Victor, Adriano M Assis, Roberto F Almeida, Diogo O G de Souza, Victor Diógenes A Silva, Silvia L Costa. Monocrotaline induces acutely cerebrovascular lesions, astrogliosis and neuronal degeneration associated with behavior changes in rats: A model of vascular damage in perspective. Neurotoxicology. 2023 01; 94(?):59-70. doi: 10.1016/j.neuro.2022.10.017. [PMID: 36336098]
  • Yi Xiao, Haomin Yi, Guofang Wang, Suhua Chen, Xiang Li, Qinyu Wu, Siyi Zhang, Kexin Deng, Yisheng He, Xiaoping Yang. Electrochemiluminescence sensor for point-of-care detection of pyrrolizidine alkaloids. Talanta. 2022 Nov; 249(?):123645. doi: 10.1016/j.talanta.2022.123645. [PMID: 35700647]
  • C U Becker, C L Sartório, C Campos-Carraro, R Siqueira, R Colombo, A Zimmer, A Belló-Klein. Exercise training decreases oxidative stress in skeletal muscle of rats with pulmonary arterial hypertension. Archives of physiology and biochemistry. 2022 Oct; 128(5):1330-1338. doi: 10.1080/13813455.2020.1769679. [PMID: 32449880]
  • Xiaoyi Hu, Qian Wang, Hui Zhao, Wenhui Wu, Qinhua Zhao, Rong Jiang, Jinming Liu, Lan Wang, Ping Yuan. Role of miR-21-5p/FilGAP axis in estradiol alleviating the progression of monocrotaline-induced pulmonary hypertension. Animal models and experimental medicine. 2022 09; 5(3):217-226. doi: 10.1002/ame2.12253. [PMID: 35713208]
  • Hiroto Yamazaki, Hidehiro Tajima, Yasuhiko Yamamoto, Seiichi Munesue, Mitsuyoshi Okazaki, Yoshinao Ohbatake, Shinichi Nakanuma, Isamu Makino, Tomoharu Miyashita, Hiroyuki Takamura, Tetsuo Ohta. Thrombopoietin accumulation in hepatocytes induces a decrease in its serum levels in a sinusoidal obstruction syndrome model. Molecular medicine reports. 2022 Jun; 25(6):. doi: 10.3892/mmr.2022.12717. [PMID: 35475446]
  • Na He, Xuan Li, Zhimin Luo, Lu Wang, Xia Cui, Qiang Fu. Preparation of molecularly imprinted foam for selective extraction of toxic monocrotaline from herbs. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jun; 1200(?):123273. doi: 10.1016/j.jchromb.2022.123273. [PMID: 35537311]
  • Anna Krzyżewska, Marta Baranowska-Kuczko, Anna Jastrząb, Irena Kasacka, Hanna Kozłowska. Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension. Molecules (Basel, Switzerland). 2022 May; 27(10):. doi: 10.3390/molecules27103327. [PMID: 35630804]
  • Richard Mprah, Yanhong Ma, Gabriel Komla Adzika, Marie Louise Ndzie Noah, Adebayo O Adekunle, Maxwell Duah, Joseph Adu-Amankwaah, Prosperl Ivette Wowui, Jennifer Dumebi Okwuma, Weili Qiao, Cheng Wang. Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension. Clinical and experimental pharmacology & physiology. 2022 05; 49(5):558-566. doi: 10.1111/1440-1681.13633. [PMID: 35133684]
  • Izabela Jarabicová, Csaba Horváth, Eva Veľasová, Lenka Bies Piváčková, Jana Vetešková, Ján Klimas, Peter Křenek, Adriana Adameová. Analysis of necroptosis and its association with pyroptosis in organ damage in experimental pulmonary arterial hypertension. Journal of cellular and molecular medicine. 2022 05; 26(9):2633-2645. doi: 10.1111/jcmm.17272. [PMID: 35393789]
  • Yi Tang, Siyuan Tan, Minqi Li, Yijin Tang, Xiaoping Xu, Qinghai Zhang, Qinghua Fu, Mingxiang Tang, Jin He, Yi Zhang, Zhaofen Zheng, Jianqiang Peng, Tengteng Zhu, Wenlin Xie. Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension. BMC pulmonary medicine. 2022 Apr; 22(1):142. doi: 10.1186/s12890-022-01939-7. [PMID: 35413880]
  • Yazhou Sun, Weiguo Wan, Xin Zhao, Xueyu Han, Tianxin Ye, Xiaoli Chen, Qian Ran, Xiukun Wang, Xin Liu, Chuan Qu, Shaobo Shi, Cui Zhang, Bo Yang. Chronic Sigma 1 receptor activation alleviates right ventricular dysfunction secondary to pulmonary arterial hypertension. Bioengineered. 2022 04; 13(4):10843-10856. doi: 10.1080/21655979.2022.2065953. [PMID: 35473584]
  • Sara Abdelfatah, Janine Naß, Caroline Knorz, Sabine M Klauck, Jan-Heiner Küpper, Thomas Efferth. Pyrrolizidine alkaloids cause cell cycle and DNA damage repair defects as analyzed by transcriptomics in cytochrome P450 3A4-overexpressing HepG2 clone 9 cells. Cell biology and toxicology. 2022 04; 38(2):325-345. doi: 10.1007/s10565-021-09599-9. [PMID: 33884520]
  • Di Chen, Tianyi Yuan, Yucai Chen, Huifang Zhang, Ziran Niu, Lianhua Fang, Guanhua Du. DL0805-1, a novel Rho-kinase inhibitor, attenuates lung injury and vasculopathy in a rat model of monocrotaline-induced pulmonary hypertension. European journal of pharmacology. 2022 Mar; 919(?):174779. doi: 10.1016/j.ejphar.2022.174779. [PMID: 35092757]
  • Shan-Shan Xie, Yan Deng, Sheng-Lan Guo, Jia-Quan Li, Ying-Chuan Zhou, Juan Liao, Dan-Dan Wu, Wei-Fang Lan. Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation. Scientific reports. 2022 02; 12(1):3056. doi: 10.1038/s41598-022-06848-7. [PMID: 35197507]
  • Zhuangzhuang Jia, Haifeng Yan, Shuai Wang, Lin Wang, Yawen Cao, Shanshan Lin, Zeyu Zhang, Ci Wang, Xianliang Wang, Jingyuan Mao. Shufeiya Recipe Improves Monocrotaline-Induced Pulmonary Hypertension in Rats by Regulating SIRT3/FOXO3a and Its Downstream Signaling Pathways. Disease markers. 2022; 2022(?):3229888. doi: 10.1155/2022/3229888. [PMID: 35222742]
  • C Rech, L P Ribeiro, J M S Bento, C A Pott, C Nardi. Monocrotaline presence in the Crotalaria (Fabaceae) plant genus and its influence on arthropods in agroecosystems. Brazilian journal of biology = Revista brasleira de biologia. 2022; 84(?):e256916. doi: 10.1590/1519-6984.256916. [PMID: 35043839]
  • Feifei Lin, Anni Pan, Yang Ye, Jia Liu. Simultaneous determination of monocrotaline and its N-oxide metabolite in rat plasma using LC-MS/MS: Application to a pharmacokinetic study. Biomedical chromatography : BMC. 2021 Dec; 35(12):e5207. doi: 10.1002/bmc.5207. [PMID: 34184288]
  • Sasha Z Prisco, Megan Eklund, Daphne M Moutsoglou, Anthony R Prisco, Alexander Khoruts, E Kenneth Weir, Thenappan Thenappan, Kurt W Prins. Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension. Journal of the American Heart Association. 2021 11; 10(22):e022722. doi: 10.1161/jaha.121.022722. [PMID: 34747187]
  • Yingjie Lv, Pengsheng Ma, Jialing Wang, Qingbin Xu, Jun Fan, Lin Yan, Ping Ma, Ru Zhou. Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension. European journal of pharmacology. 2021 Nov; 910(?):174311. doi: 10.1016/j.ejphar.2021.174311. [PMID: 34245749]
  • Firoozeh Farahmand, Akshi Malik, Anita Sharma, Ashim K Bagchi, Pawan K Singal. Role of oxidative stress versus lipids in monocrotaline-induced pulmonary hypertension and right heart failure. Physiological reports. 2021 11; 9(22):e15090. doi: 10.14814/phy2.15090. [PMID: 34816616]
  • Jing-Jing Zhou, Huang Li, Li Li, Yue Li, Pei-He Wang, Xian-Min Meng, Jian-Guo He. CYLD mediates human pulmonary artery smooth muscle cell dysfunction in congenital heart disease-associated pulmonary arterial hypertension. Journal of cellular physiology. 2021 09; 236(9):6297-6311. doi: 10.1002/jcp.30298. [PMID: 33507567]
  • Patrick Diaba-Nuhoho, Martin Cour, Nkanyiso Hadebe, David Marais, Sandrine Lecour, Dee Blackhurst. Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension. BMC research notes. 2021 Aug; 14(1):324. doi: 10.1186/s13104-021-05738-x. [PMID: 34425891]
  • Laurent Savale, Satoshi Akagi, Ly Tu, Amélie Cumont, Raphaël Thuillet, Carole Phan, Benjamin Le Vely, Nihel Berrebeh, Alice Huertas, Xavier Jaïs, Vincent Cottin, Ari Chaouat, Cécile Tromeur, Athénaïs Boucly, Etienne Marie Jutant, Olaf Mercier, Elie Fadel, David Montani, Olivier Sitbon, Marc Humbert, Yuichi Tamura, Christophe Guignabert. Serum and pulmonary uric acid in pulmonary arterial hypertension. The European respiratory journal. 2021 08; 58(2):. doi: 10.1183/13993003.00332-2020. [PMID: 33446602]
  • Thaïs Hautbergue, Fabrice Antigny, Angèle Boët, François Haddad, Bastien Masson, Mélanie Lambert, Amélie Delaporte, Jean-Baptiste Menager, Laurent Savale, Jérôme Le Pavec, Elie Fadel, Marc Humbert, Christophe Junot, François Fenaille, Benoit Colsch, Olaf Mercier. Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure. Cells. 2021 06; 10(6):. doi: 10.3390/cells10061559. [PMID: 34205639]
  • Soodeh Rajabi, Hamid Najafipour, Saeideh Jafarinejad-Farsangi, Siyavash Joukar, Ahmad Beik, Majid Askaripour, Elham Jafari, Zohreh Safi. Quercetin, Perillyl Alcohol, and Berberine Ameliorate Right Ventricular Disorders in Experimental Pulmonary Arterial Hypertension: Effects on miR-204, miR-27a, Fibrotic, Apoptotic, and Inflammatory Factors. Journal of cardiovascular pharmacology. 2021 06; 77(6):777-786. doi: 10.1097/fjc.0000000000001015. [PMID: 34016844]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tomohito Ishikawa, Kohtaro Abe, Mariko Takana-Ishikawa, Keimei Yoshida, Takanori Watanabe, Satomi Imakiire, Kazuya Hosokawa, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui. Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats. Journal of the American Heart Association. 2021 04; 10(7):e019247. doi: 10.1161/jaha.120.019247. [PMID: 33787285]
  • Haifeng Jin, Yu Jiao, Linna Guo, Yong Ma, Rongjie Zhao, Xuemei Li, Lei Shen, Zhongguang Zhou, Sang Chan Kim, Jicheng Liu. Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension by improving inflammation and pulmonary artery remodeling. International journal of molecular medicine. 2021 02; 47(2):595-606. doi: 10.3892/ijmm.2020.4813. [PMID: 33416126]
  • Yisheng He, Wei Lian, Liang Ding, Xiaoyu Fan, Jiang Ma, Qing-Yu Zhang, Xinxin Ding, Ge Lin. Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites. Archives of toxicology. 2021 01; 95(1):103-116. doi: 10.1007/s00204-020-02921-0. [PMID: 33033841]
  • Masashi Tawa, Rikako Nagata, Yuiko Sumi, Keisuke Nakagawa, Tatsuya Sawano, Mamoru Ohkita, Yasuo Matsumura. Preventive effects of nitrate-rich beetroot juice supplementation on monocrotaline-induced pulmonary hypertension in rats. PloS one. 2021; 16(4):e0249816. doi: 10.1371/journal.pone.0249816. [PMID: 33831045]
  • Lu Gao, Shao-Dan Li, Yin Zhang, Yi Liu, Ming-Hui Yang. Early Intervention of Tongxinluo () on Right Ventricular Function Assessed by Echocardiography in Rats with Pulmonary Arterial Hypertension Induced by Monocrotaline. Chinese journal of integrative medicine. 2020 Dec; 26(12):913-920. doi: 10.1007/s11655-020-3229-x. [PMID: 32418178]
  • Lukas Rutz, Lan Gao, Jan-Heiner Küpper, Dieter Schrenk. Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells. Archives of toxicology. 2020 12; 94(12):4159-4172. doi: 10.1007/s00204-020-02895-z. [PMID: 32910235]
  • Tamires Scupinari, Helena Mannochio Russo, Anna Beatriz Sabino Ferrari, Vanderlan da Silva Bolzani, Waldir Pereira Dias, Estela de Oliveira Nunes, Clara Beatriz Hoffmann-Campo, Maria Luiza Zeraik. Crotalaria spectabilis as a source of pyrrolizidine alkaloids and phenolic compounds: HPLC-MS/MS dereplication and monocrotaline quantification of seed and leaf extracts. Phytochemical analysis : PCA. 2020 Nov; 31(6):747-755. doi: 10.1002/pca.2938. [PMID: 32428987]
  • Jovana Jakovljevic Uzelac, Tatjana Djukic, Tanja Radic, Slavica Mutavdzin, Sanja Stankovic, Jelena Kostic Rakocevic, Milica Labudovic Borovic, Natasa Milic, Tatjana Simic, Ana Savic-Radojevic, Dragan Djuric. Folic acid affects cardiometabolic, oxidative stress, and immunohistochemical parameters in monocrotaline-induced rat heart failure. Canadian journal of physiology and pharmacology. 2020 Oct; 98(10):708-716. doi: 10.1139/cjpp-2020-0030. [PMID: 32353247]
  • Olga Sadowska, Marta Baranowska-Kuczko, Anna Gromotowicz-Popławska, Michał Biernacki, Aleksandra Kicman, Barbara Malinowska, Irena Kasacka, Anna Krzyżewska, Hanna Kozłowska. Cannabidiol Ameliorates Monocrotaline-Induced Pulmonary Hypertension in Rats. International journal of molecular sciences. 2020 Sep; 21(19):. doi: 10.3390/ijms21197077. [PMID: 32992900]
  • Akira Sugiyama, Maina Kaisho, Muneyoshi Okada, Kosuke Otani, Hideyuki Yamawaki. Decreased Expression of Canstatin in Rat Model of Monocrotaline-Induced Pulmonary Arterial Hypertension: Protective Effect of Canstatin on Right Ventricular Remodeling. International journal of molecular sciences. 2020 Sep; 21(18):. doi: 10.3390/ijms21186797. [PMID: 32947968]
  • Suparmi Suparmi, Sebastiaan Wesseling, Ivonne M C M Rietjens. Monocrotaline-induced liver toxicity in rat predicted by a combined in vitro physiologically based kinetic modeling approach. Archives of toxicology. 2020 09; 94(9):3281-3295. doi: 10.1007/s00204-020-02798-z. [PMID: 32518961]
  • Denise Lacerda, Patrick Türck, Cristina Campos-Carraro, Alexandre Hickmann, Vanessa Ortiz, Sara Bianchi, Adriane Belló-Klein, Alexandre Luz de Castro, Valquiria Linck Bassani, Alex Sander da Rosa Araujo. Pterostilbene improves cardiac function in a rat model of right heart failure through modulation of calcium handling proteins and oxidative stress. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2020 Sep; 45(9):987-995. doi: 10.1139/apnm-2019-0864. [PMID: 32191845]
  • Mahin Dianat, Maryam Radan, Seyyed Ali Mard, Farzaneh Sohrabi, Sadaf Sadeghi Nezhad Saryazdi. Contribution of reactive oxygen species via the OXR1 signaling pathway in the pathogenesis of monocrotaline-induced pulmonary arterial hypertension: The protective role of Crocin. Life sciences. 2020 Sep; 256(?):117848. doi: 10.1016/j.lfs.2020.117848. [PMID: 32585243]
  • Soodeh Rajabi, Hamid Najafipour, Saeideh Jafarinejad Farsangi, Siyavash Joukar, Ahmad Beik, Maryam Iranpour, Zeinab Kordestani. Perillyle alcohol and Quercetin ameliorate monocrotaline-induced pulmonary artery hypertension in rats through PARP1-mediated miR-204 down-regulation and its downstream pathway. BMC complementary medicine and therapies. 2020 Jul; 20(1):218. doi: 10.1186/s12906-020-03015-1. [PMID: 32660602]
  • Yuqin Chen, Wenju Lu, Kai Yang, Xin Duan, Mengxi Li, Xiuqing Chen, Jie Zhang, Meidan Kuang, Shiyun Liu, Xiongting Wu, Guofa Zou, Chunli Liu, Cheng Hong, Wenjun He, Jing Liao, Chi Hou, Zhe Zhang, Qiuyu Zheng, Jiyuan Chen, Nuofu Zhang, Haiyang Tang, Rebecca R Vanderpool, Ankit A Desai, Franz Rischard, Stephen M Black, Joe G N Garcia, Ayako Makino, Jason X-J Yuan, Nanshan Zhong, Jian Wang. Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension. British journal of pharmacology. 2020 06; 177(12):2743-2764. doi: 10.1111/bph.15000. [PMID: 31976548]
  • Yilin Wang, Yu Wang, Chengxi Wei, Quan Wan, Zhifei Fan, Liying Xuan, Wanru Geng, Liqun Shao, Jie Long, Junyi Gu, Ming Zhao. Trapidil determines the fate of RHF rats through inhibition of ER stress. Archives of pharmacal research. 2020 Apr; 43(4):409-420. doi: 10.1007/s12272-020-01222-5. [PMID: 32172437]
  • Olga Rafikova, Joel James, Cody A Eccles, Sergey Kurdyukov, Maki Niihori, Mathews Valuparampil Varghese, Ruslan Rafikov. Early progression of pulmonary hypertension in the monocrotaline model in males is associated with increased lung permeability. Biology of sex differences. 2020 03; 11(1):11. doi: 10.1186/s13293-020-00289-5. [PMID: 32188512]
  • Wen-Xiu Xin, Qing-Lin Li, Luo Fang, Li-Ke Zhong, Xiao-Wei Zheng, Ping Huang. Preventive Effect and Mechanism of Ethyl Acetate Extract of Sceptridium ternatum in Monocrotaline-Induced Pulmonary Arterial Hypertension. Chinese journal of integrative medicine. 2020 Mar; 26(3):205-211. doi: 10.1007/s11655-018-2573-6. [PMID: 30591962]
  • Henry Daniell, Venkata Mangu, Bakhtiyor Yakubov, Jiyoung Park, Peyman Habibi, Yao Shi, Patricia A Gonnella, Amanda Fisher, Todd Cook, Lily Zeng, Steven M Kawut, Tim Lahm. Investigational new drug enabling angiotensin oral-delivery studies to attenuate pulmonary hypertension. Biomaterials. 2020 03; 233(?):119750. doi: 10.1016/j.biomaterials.2019.119750. [PMID: 31931441]
  • Patrick Türck, Schauana Fraga, Isadora Salvador, Cristina Campos-Carraro, Denise Lacerda, Alan Bahr, Vanessa Ortiz, Alexandre Hickmann, Mariana Koetz, Adriane Belló-Klein, Amélia Henriques, Fabiana Agostini, Alex Sander da Rosa Araujo. Blueberry extract decreases oxidative stress and improves functional parameters in lungs from rats with pulmonary arterial hypertension. Nutrition (Burbank, Los Angeles County, Calif.). 2020 02; 70(?):110579. doi: 10.1016/j.nut.2019.110579. [PMID: 31743815]
  • Chenyang Chen, Fei Luo, Panyun Wu, Yiyuan Huang, Avash Das, Shenglan Chen, Jingyuan Chen, Xinqun Hu, Fei Li, Zhenfei Fang, Shenhua Zhou. Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China. Journal of cellular and molecular medicine. 2020 02; 24(4):2484-2496. doi: 10.1111/jcmm.14937. [PMID: 31945804]
  • Eva Malikova, Mattias Carlström, Zuzana Kmecova, Margareta Marusakova, Bianka Zsigmondova, Peter Krenek, Jan Klimas, Dan Henrohn. Effects of inorganic nitrate in a rat model of monocrotaline-induced pulmonary arterial hypertension. Basic & clinical pharmacology & toxicology. 2020 Feb; 126(2):99-109. doi: 10.1111/bcpt.13309. [PMID: 31429204]
  • Li-Cai An, Xi-Jing Li, Ying-Hui Liu, Xiao-Qian Liu, Yuan-Feng Zhang, Yan-Ming Wang, Xiao-Xia Chu. [Proventive and Therapentic Effects of Endothelial Progenitor Cells on Monocrotaline-Induced Hepatic Vein Occlusion Disease]. Zhongguo shi yan xue ye xue za zhi. 2020 Feb; 28(1):242-247. doi: 10.19746/j.cnki.issn.1009-2137.2020.01.041. [PMID: 32027284]
  • Liang Ζ Zhang, Zhi-Ru Fan, Lu Wang, Lu-Qian Liu, Xin-Zhi Li, Li Li, Jun-Qiang Si, Ke-Tao Ma. Carbenoxolone decreases monocrotaline‑induced pulmonary inflammation and pulmonary arteriolar remodeling in rats by decreasing the expression of connexins in T lymphocytes. International journal of molecular medicine. 2020 01; 45(1):81-92. doi: 10.3892/ijmm.2019.4406. [PMID: 31746364]
  • Tangzhiming Li, Suqi Li, Yilu Feng, Xiaofang Zeng, Shaohong Dong, Jianghua Li, Lihuang Zha, Hui Luo, Lin Zhao, Bin Liu, Ziwei Ou, Wenchao Lin, Mengqiu Zhang, Sheng Li, Qiuqiong Jiang, Qiangqiang Qi, Qingyao Xu, Zaixin Yu. Combination of Dichloroacetate and Atorvastatin Regulates Excessive Proliferation and Oxidative Stress in Pulmonary Arterial Hypertension Development via p38 Signaling. Oxidative medicine and cellular longevity. 2020; 2020(?):6973636. doi: 10.1155/2020/6973636. [PMID: 32617141]
  • Shao Ouyang, Wei Chen, Gaofeng Zeng, Changcheng Lei. Aquaporin-2 expression in the kidney and urine is elevated in rats with monocrotaline-induced pulmonary heart disease. The Journal of international medical research. 2020 Jan; 48(1):300060519894448. doi: 10.1177/0300060519894448. [PMID: 32000538]
  • Jing Guo, Zu-Cheng Yang, Yi Liu. Attenuating Pulmonary Hypertension by Protecting the Integrity of Glycocalyx in Rats Model of Pulmonary Artery Hypertension. Inflammation. 2019 Dec; 42(6):1951-1956. doi: 10.1007/s10753-019-01055-5. [PMID: 31267273]
  • Zhenlin Huang, Qing Zhao, Minwei Chen, Jingnan Zhang, Lili Ji. Liquiritigenin and liquiritin alleviated monocrotaline-induced hepatic sinusoidal obstruction syndrome via inhibiting HSP60-induced inflammatory injury. Toxicology. 2019 12; 428(?):152307. doi: 10.1016/j.tox.2019.152307. [PMID: 31589899]
  • Zhenlin Huang, Minwei Chen, Mengjuan Wei, Bin Lu, Xiaojun Wu, Zhengtao Wang, Lili Ji. Liver Inflammatory Injury Initiated by DAMPs-TLR4-MyD88/TRIF-NFκB Signaling Pathway Is Involved in Monocrotaline-Induced HSOS. Toxicological sciences : an official journal of the Society of Toxicology. 2019 12; 172(2):385-397. doi: 10.1093/toxsci/kfz193. [PMID: 31504964]
  • Lamei Yu, Weijian Li, Byung Mun Park, Gi-Ja Lee, Suhn Hee Kim. Hypoxia augments NaHS-induced ANP secretion via KATP channel, HIF-1α and PPAR-γ pathway. Peptides. 2019 11; 121(?):170123. doi: 10.1016/j.peptides.2019.170123. [PMID: 31386893]
  • Zi Ping Leong, Yoshiaki Hikasa. Effects of masitinib compared with tadalafil for the treatment of monocrotaline-induced pulmonary arterial hypertension in rats. Vascular pharmacology. 2019 Nov; 122-123(?):106599. doi: 10.1016/j.vph.2019.106599. [PMID: 31629919]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Jun-Han Zhao, Yang-Yang He, Shan-Shan Guo, Yi Yan, Zhe Wang, Jue Ye, Jin-Lan Zhang, Yong Wang, Xiao-Bin Pang, Xin-Mei Xie, Jian-Hui Lin, Zhi-Cheng Jing, Zhi-Yan Han. Circulating Plasma Metabolomic Profiles Differentiate Rodent Models of Pulmonary Hypertension and Idiopathic Pulmonary Arterial Hypertension Patients. American journal of hypertension. 2019 10; 32(11):1109-1117. doi: 10.1093/ajh/hpz121. [PMID: 31350549]
  • Chao-Yuan Chang, Hung-Jen Shih, I-Tao Huang, Pei-Shan Tsai, Kung-Yen Chen, Chun-Jen Huang. Magnesium Sulfate Mitigates the Progression of Monocrotaline Pulmonary Hypertension in Rats. International journal of molecular sciences. 2019 Sep; 20(18):. doi: 10.3390/ijms20184622. [PMID: 31540416]
  • Nikola Hadzi-Petrushev, Marija Angelovski, Katerina Rebok, Vadim Mitrokhin, Andre Kamkin, Mitko Mladenov. Antioxidant and anti-inflammatory effects of the monocarbonyl curcumin analogs B2BRBC and C66 in monocrotaline-induced right ventricular hypertrophy. Journal of biochemical and molecular toxicology. 2019 Aug; 33(8):e22353. doi: 10.1002/jbt.22353. [PMID: 31407471]
  • Jia-Yin Chen, Jürgen Brockmöller, Mladen V Tzvetkov, Li-Jun Wang, Xi-Jing Chen. An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families. Chinese journal of natural medicines. 2019 Jul; 17(7):490-497. doi: 10.1016/s1875-5364(19)30070-6. [PMID: 31514980]
  • Yo Muraki, Takako Naito, Kimio Tohyama, Sachio Shibata, Kanako Kuniyeda, Yasunori Nio, Masatoshi Hazama, Takanori Matsuo. Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension. Bioscience, biotechnology, and biochemistry. 2019 Jun; 83(6):1000-1010. doi: 10.1080/09168451.2019.1584520. [PMID: 30835622]
  • Xue-Liang Zhou, Zhi-Bo Liu, Rong-Rong Zhu, Huang Huang, Qi-Rong Xu, Hua Xu, Liang Zeng, Yun-Yun Li, Cha-Hua Huang, Qi-Cai Wu, Ji-Chun Liu. NSD2 silencing alleviates pulmonary arterial hypertension by inhibiting trehalose metabolism and autophagy. Clinical science (London, England : 1979). 2019 05; 133(9):1085-1096. doi: 10.1042/cs20190142. [PMID: 31040165]
  • Fan Yang, Li Li, Rui Yang, Mengjuan Wei, Yuchen Sheng, Lili Ji. Identification of serum microRNAs as potential toxicological biomarkers for toosendanin-induced liver injury in mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 May; 58(?):152867. doi: 10.1016/j.phymed.2019.152867. [PMID: 30844585]
  • Fangzheng Chen, Heng Wang, Jie Zhao, Junjie Yan, Hanyan Meng, Huilu Zhan, Luowei Chen, Linbo Yuan. Grape seed proanthocyanidin inhibits monocrotaline-induced pulmonary arterial hypertension via attenuating inflammation: in vivo and in vitro studies. The Journal of nutritional biochemistry. 2019 05; 67(?):72-77. doi: 10.1016/j.jnutbio.2019.01.013. [PMID: 30856466]
  • Jinyuan Luo, Xiaojing Yang, Shuaikai Qiu, Xia Li, E Xiang, Yan Fang, Yanqing Wang, Li Zhang, Hui Wang, Jiang Zheng, Yu Guo. Sex difference in monocrotaline-induced developmental toxicity and fetal hepatotoxicity in rats. Toxicology. 2019 04; 418(?):32-40. doi: 10.1016/j.tox.2019.02.014. [PMID: 30825512]
  • Yu Guo, Di Xiao, Xiaojing Yang, Jiang Zheng, Shuwei Hu, Panfeng Wu, Xiaoxia Li, Hao Kou, Hui Wang. Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats. Reproductive toxicology (Elmsford, N.Y.). 2019 04; 85(?):34-41. doi: 10.1016/j.reprotox.2019.02.006. [PMID: 30771476]
  • Yi-Dan Wang, Yi-Dan Li, Xue-Yan Ding, Xiao-Peng Wu, Cheng Li, Di-Chen Guo, Yan-Ping Shi, Xiu-Zhang Lu. 17β-estradiol preserves right ventricular function in rats with pulmonary arterial hypertension: an echocardiographic and histochemical study. The international journal of cardiovascular imaging. 2019 Mar; 35(3):441-450. doi: 10.1007/s10554-018-1468-0. [PMID: 30350115]
  • Hui Qin Chen, Ke Feng Cai. [The intervention of ginkgo biloba extract on monocrotaline-induced right ventricular hypertrophy in rats and its mechanism]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2019 Feb; 35(2):169-172. doi: 10.12047/j.cjap.5759.2019.037. [PMID: 31250611]
  • Masashi Tawa, Yoko Yano, Misaki Yamanaka, Tatsuya Sawano, Kana Iesaki, Yuka Murata, Ryosuke Tanaka, Keisuke Nakagawa, Mamoru Ohkita, Yasuo Matsumura. Effects of Beet Juice Supplementation on Monocrotaline-Induced Pulmonary Hypertension in Rats. American journal of hypertension. 2019 01; 32(2):216-222. doi: 10.1093/ajh/hpy144. [PMID: 30265283]
  • Michal Radik, Zuzana Kmecova, Jana Veteskova, Eva Malikova, Gabriel Doka, Peter Krenek, Jan Klimas. Hepatocyte growth factor plays a particular role in progression of overall cardiac damage in experimental pulmonary hypertension. International journal of medical sciences. 2019; 16(6):854-863. doi: 10.7150/ijms.31690. [PMID: 31337959]
  • Hua Su, Xiaoling Xu, Chao Yan, Yangfeng Shi, Yanjie Hu, Liangliang Dong, Songmin Ying, Kejing Ying, Ruifeng Zhang. LncRNA H19 promotes the proliferation of pulmonary artery smooth muscle cells through AT1R via sponging let-7b in monocrotaline-induced pulmonary arterial hypertension. Respiratory research. 2018 Dec; 19(1):254. doi: 10.1186/s12931-018-0956-z. [PMID: 30547791]
  • Sutthinee Wisutthathum, Céline Demougeot, Perle Totoson, Kannika Adthapanyawanich, Kornkanok Ingkaninan, Prapapan Temkitthawon, Krongkarn Chootip. Eulophia macrobulbon extract relaxes rat isolated pulmonary artery and protects against monocrotaline-induced pulmonary arterial hypertension. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Nov; 50(?):157-165. doi: 10.1016/j.phymed.2018.05.014. [PMID: 30466974]
  • Cristina Campos-Carraro, Patrick Turck, Bruna Gazzi de Lima-Seolin, Angela Maria Vicente Tavares, Denise Dos Santos Lacerda, Giana Blume Corssac, Rayane Brinck Teixeira, Alexandre Hickmann, Susana Llesuy, Alex Sander da Rosa Araujo, Adriane Belló-Klein. Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats. Journal of cardiovascular pharmacology. 2018 11; 72(5):214-221. doi: 10.1097/fjc.0000000000000617. [PMID: 30212415]
  • Elisabet Ferrer, Benjamin J Dunmore, Dhiya Hassan, Mark L Ormiston, Stephen Moore, John Deighton, Lu Long, Xu Dong Yang, Duncan J Stewart, Nicholas W Morrell. A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension. American journal of respiratory cell and molecular biology. 2018 10; 59(4):467-478. doi: 10.1165/rcmb.2017-0129oc. [PMID: 29676587]
  • Zhenlin Huang, Yuchen Sheng, Minwei Chen, Zhanxia Hao, Feifei Hu, Lili Ji. Liquiritigenin and liquiritin alleviated MCT-induced HSOS by activating Nrf2 antioxidative defense system. Toxicology and applied pharmacology. 2018 09; 355(?):18-27. doi: 10.1016/j.taap.2018.06.014. [PMID: 29908794]
  • Masaki Takeuchi, Shingo Oda, Koichi Tsuneyama, Tsuyoshi Yokoi. Comprehensive analysis of serum microRNAs in hepatic sinusoidal obstruction syndrome (SOS) in rats: implication as early phase biomarkers for SOS. Archives of toxicology. 2018 09; 92(9):2947-2962. doi: 10.1007/s00204-018-2269-x. [PMID: 30019166]
  • Wei Zhuang, Guili Lian, Bangbang Huang, Apang Du, Genfa Xiao, Jin Gong, Changsheng Xu, Huajun Wang, Liangdi Xie. Pulmonary arterial hypertension induced by a novel method: Twice-intraperitoneal injection of monocrotaline. Experimental biology and medicine (Maywood, N.J.). 2018 08; 243(12):995-1003. doi: 10.1177/1535370218794128. [PMID: 30099957]
  • Han-Ming Wang, Wan-Zhu Liu, Fu-Tian Tang, Hai-Juan Sui, Xing-Jie Zhan, Hong-Xin Wang. Cystamine slows but not inverses the progression of monocrotaline-induced pulmonary arterial hypertension in rats. Canadian journal of physiology and pharmacology. 2018 Aug; 96(8):783-789. doi: 10.1139/cjpp-2017-0720. [PMID: 29633623]
  • Patrick Türck, Denise Santos Lacerda, Cristina Campos Carraro, Bruna Gazzi de Lima-Seolin, Rayane Brinck Teixeira, Jéssica Hellen Poletto Bonetto, Rafael Colombo, Paulo Cavalheiro Schenkel, Adriane Belló-Klein, Alex Sander da Rosa Araujo. Trapidil improves hemodynamic, echocardiographic and redox state parameters of right ventricle in monocrotaline-induced pulmonary arterial hypertension model. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jul; 103(?):182-190. doi: 10.1016/j.biopha.2018.04.001. [PMID: 29653363]
  • Masashi Tawa, Takahide Furukawa, Hiroko Tongu, Mai Sugihara, Satoko Taguwa, Misaki Yamanaka, Yoko Yano, Hiroaki Matsumori, Rie Kitada, Tatsuya Sawano, Ryosuke Tanaka, Mamoru Ohkita, Yasuo Matsumura. Stimulation of nitric oxide-sensitive soluble guanylate cyclase in monocrotaline-induced pulmonary hypertensive rats. Life sciences. 2018 Jun; 203(?):203-209. doi: 10.1016/j.lfs.2018.04.045. [PMID: 29705351]
  • Ravindra K Sharma, Aline C Oliveira, Seungbum Kim, Katya Rigatto, Jasenka Zubcevic, Anandharajan Rathinasabapathy, Ashok Kumar, Joseph J Lebowitz, Habibeh Khoshbouei, Gilberto Lobaton, Victor Aquino, Elaine M Richards, Michael J Katovich, Vinayak Shenoy, Mohan K Raizada. Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension. Hypertension (Dallas, Tex. : 1979). 2018 06; 71(6):1156-1163. doi: 10.1161/hypertensionaha.118.10934. [PMID: 29712738]
  • Hai-Kuo Zheng, Jun-Han Zhao, Yi Yan, Tian-Yu Lian, Jue Ye, Xiao-Jian Wang, Zhe Wang, Zhi-Cheng Jing, Yang-Yang He, Ping Yang. Metabolic reprogramming of the urea cycle pathway in experimental pulmonary arterial hypertension rats induced by monocrotaline. Respiratory research. 2018 05; 19(1):94. doi: 10.1186/s12931-018-0800-5. [PMID: 29751839]
  • Fengjiao Sun, Zhiqiang Lu, Yidan Zhang, Shihan Geng, Mengxi Xu, Liman Xu, Yingying Huang, Pengwei Zhuang, Yanjun Zhang. Stage‑dependent changes of β2‑adrenergic receptor signaling in right ventricular remodeling in monocrotaline‑induced pulmonary arterial hypertension. International journal of molecular medicine. 2018 May; 41(5):2493-2504. doi: 10.3892/ijmm.2018.3449. [PMID: 29393391]
  • Olga Rafikova, Anup Srivastava, Ankit A Desai, Ruslan Rafikov, Stevan P Tofovic. Recurrent inhibition of mitochondrial complex III induces chronic pulmonary vasoconstriction and glycolytic switch in the rat lung. Respiratory research. 2018 04; 19(1):69. doi: 10.1186/s12931-018-0776-1. [PMID: 29685148]
  • Xiaoqi Jing, Jiaqi Zhang, Zhenlin Huang, Yuchen Sheng, Lili Ji. The involvement of Nrf2 antioxidant signalling pathway in the protection of monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats by (+)-catechin hydrate. Free radical research. 2018 Apr; 52(4):402-414. doi: 10.1080/10715762.2018.1437914. [PMID: 29458270]
  • Yo Muraki, Midori Yamasaki, Hirohisa Takeuchi, Kimio Tohyama, Noriyasu Sano, Takanori Matsuo. Fluorescent Imaging Analysis for Distribution of Fluorescent Dye Labeled- or Encapsulated-Liposome in Monocrotaline-Induced Pulmonary Hypertension Model Rat. Chemical & pharmaceutical bulletin. 2018 Mar; 66(3):270-276. doi: 10.1248/cpb.c17-00811. [PMID: 29311495]
  • Bruna Gazzi de Lima-Seolin, Matheus Mittmann Hennemann, Rafael Oliveira Fernandes, Rafael Colombo, Jéssica Hellen Poletto Bonetto, Rayane Brinck Teixeira, Neelam Khaper, Alessandra Eifler Guerra Godoy, Isnard Elman Litvin, Alex Sander da Rosa Araujo, Paulo Cavalheiro Schenkel, Adriane Belló-Klein. Bucindolol attenuates the vascular remodeling of pulmonary arteries by modulating the expression of the endothelin-1 A receptor in rats with pulmonary arterial hypertension. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Mar; 99(?):704-714. doi: 10.1016/j.biopha.2018.01.127. [PMID: 29710468]
  • Z Feng, Y Hu, N N An, W J Feng, T Hu, Y J Mao. [Effect of acidic oligosaccharides on P-selectin of pulmonary hypertensive rats induced by monocrotaline]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. 2018 Feb; 41(2):90-94. doi: 10.3760/cma.j.issn.1001-0939.2018.02.004. [PMID: 29429213]