Alkannin (BioDeep_00000229890)

 

Secondary id: BioDeep_00000002647

PANOMIX_OTCML-2023 Antitumor activity natural product


代谢物信息卡片


5,8-dihydroxy-2-[(1S)-1-hydroxy-4-methylpent-3-en-1-yl]-1,4-dihydronaphthalene-1,4-dione

化学式: C16H16O5 (288.0998)
中文名称: 左旋紫草素, 紫草素, 莽草素, 阿卡宁
谱图信息: 最多检出来源 Homo sapiens(otcml) 3.15%

分子结构信息

SMILES: CC(=CCC(C1=CC(=O)C2=C(C=CC(=C2C1=O)O)O)O)C
InChI: InChI=1S/C16H16O5/c1-8(2)3-4-10(17)9-7-13(20)14-11(18)5-6-12(19)15(14)16(9)21/h3,5-7,10,17-19H,4H2,1-2H3

描述信息

Alkannin is a hydroxy-1,4-naphthoquinone.
Alkannin is a natural product found in Arnebia hispidissima, Alkanna cappadocica, and other organisms with data available.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway[1][2][3].
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway[1][2][3].
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway[1][2][3].
(-)-Alkannin, found in Alkanna tinctoria, is used as a food coloring. (-)-Alkannin shows anticancer activity, arrests cell cycle, and induces apoptosis. (-)-Alkannin improves hepatic inflammation in a Rho-kinase pathway[1][2][3].

同义名列表

41 个代谢物同义名

5,8-dihydroxy-2-[(1S)-1-hydroxy-4-methylpent-3-en-1-yl]-1,4-dihydronaphthalene-1,4-dione; 1,4-Naphthalenedione, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (S)-; 5,8-DIHYDROXY-2-((1S)-1-HYDROXY-4-METHYLPENT-3-EN-1-YL)NAPHTHALENE-1,4-DIONE; 1,4-Naphthalenedione, 5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-, (S)-; 1,4-Naphthalenedione, 5,8-dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-, (-)-; (S)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione; 5,8-Dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthalenedione, (S)-; 1,4-NAPHTHOQUINONE, 5,8-DIHYDROXY-6-(1-HYDROXY-4-METHYL-3-PENTENYL)-, (-)-; 5,8-dihydroxy-2-[(1S)-1-hydroxy-4-methyl-pent-3-enyl]naphthalene-1,4-dione; 5,8-dihydroxy-2-[(1S)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione; (-)-5,8-Dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthalenedione; (S)-5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)naphthalene-1,4-dione; (-)-5,8-dihydroxy-2-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone; (-)-5,8-Dihydroxy-6-(1-hydroxy-4-methyl-3-pentenyl)-1,4-naphthoquinone; (S)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-enyl)-1,4-naphthoquinone; 3-08-00-04089 (Beilstein Handbook Reference); (-)-(1-Hydroxy-3-isohexenyl)naphthazarine; Alkannin, analytical standard; Cerven prirodni 20 [Czech]; C.I. Natural Red 20 (VAN); Cerven prirodni 20; Anchusa acid (VAN); Alkanna red (VAN); Alkannin (VAN); Anchusaic acid; Anchusin (VAN); ALKANNIN [MI]; Anchusa acid; (-)-Alkannin; ALKANNIN(RG); Alkanna Red; Arnebin IV; SHIKALKIN; Alkannin; Anchusin; 5,8-dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)-1,4-dihydronaphthalene-1,4-dione; Alkanet extract (van); C.I. Natural Red 20; C.I. 75530; Shikonin; Alkannin



数据库引用编号

27 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ANXA5, BCL2, BCL2L1, CASP8, EGFR, MAPK14, MTOR, NFE2L2, NLRP3, PIK3CA, PKM, RIPK1, RIPK3, VEGFA
Peripheral membrane protein 2 ANXA5, MTOR
Endosome membrane 2 EGFR, RIPK1
Endoplasmic reticulum membrane 6 BCL2, CD4, EGFR, HMGCR, HMOX1, MTOR
Mitochondrion membrane 1 BCL2L1
Nucleus 11 BCL2, CASP8, EGFR, HMOX1, MAPK14, MTOR, NFE2L2, NLRP3, PKM, RIPK3, VEGFA
cytosol 14 ANXA5, BCL2, BCL2L1, CASP8, HMOX1, MAPK14, MTOR, NFE2L2, NLRP3, PIK3CA, PKM, RIPK1, RIPK3, SLC2A1
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 2 BCL2L1, NFE2L2
nucleoplasm 5 CASP8, HMOX1, MAPK14, MTOR, NFE2L2
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 CD4, EGFR, RIPK1, SLC2A1
Cytoplasmic side 3 BCL2L1, HMOX1, MTOR
lamellipodium 2 CASP8, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 HMGCR, SLC2A1
Golgi apparatus membrane 2 MTOR, NLRP3
cell junction 1 EGFR
cell surface 2 EGFR, VEGFA
glutamatergic synapse 2 EGFR, MAPK14
Golgi apparatus 2 NFE2L2, VEGFA
Golgi membrane 4 EGFR, MTOR, NLRP3, SLC2A1
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 BCL2L1
sarcolemma 2 ANXA5, SLC2A1
Cytoplasm, cytosol 4 BCL2L1, NFE2L2, NLRP3, RIPK3
Lysosome 1 MTOR
Presynapse 1 SLC2A1
endosome 1 EGFR
plasma membrane 6 CD4, EGFR, NFE2L2, PIK3CA, RIPK1, SLC2A1
synaptic vesicle membrane 1 BCL2L1
Membrane 9 ANXA5, BCL2, EGFR, HMGCR, HMOX1, MTOR, NLRP3, SLC2A1, VEGFA
apical plasma membrane 2 EGFR, SLC2A1
basolateral plasma membrane 2 EGFR, SLC2A1
caveola 1 SLC2A1
extracellular exosome 3 ANXA5, PKM, SLC2A1
Lysosome membrane 1 MTOR
endoplasmic reticulum 6 BCL2, BCL2L1, HMGCR, HMOX1, NLRP3, VEGFA
extracellular space 5 CXCL8, EGFR, HMOX1, IL10, VEGFA
perinuclear region of cytoplasm 3 EGFR, HMOX1, PIK3CA
adherens junction 1 VEGFA
intercalated disc 2 PIK3CA, SLC2A1
mitochondrion 7 BCL2, BCL2L1, CASP8, MAPK14, NLRP3, PKM, RIPK1
protein-containing complex 5 BCL2, CASP8, EGFR, RIPK1, RIPK3
Microsome membrane 1 MTOR
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 CD4, EGFR
Secreted 4 CXCL8, IL10, NLRP3, VEGFA
extracellular region 7 ANXA5, CXCL8, IL10, MAPK14, NLRP3, PKM, VEGFA
Mitochondrion outer membrane 3 BCL2, BCL2L1, MTOR
Single-pass membrane protein 2 BCL2, BCL2L1
mitochondrial outer membrane 5 BCL2, BCL2L1, CASP8, HMOX1, MTOR
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 1 BCL2L1
photoreceptor inner segment 1 SLC2A1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, EGFR
external side of plasma membrane 2 ANXA5, CD4
Extracellular vesicle 1 PKM
Secreted, extracellular space, extracellular matrix 1 VEGFA
Z disc 1 SLC2A1
midbody 1 SLC2A1
Early endosome 1 CD4
vesicle 1 PKM
Cell projection, lamellipodium 1 CASP8
Membrane raft 2 CD4, EGFR
pore complex 1 BCL2
focal adhesion 2 ANXA5, EGFR
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
peroxisomal membrane 1 HMGCR
Nucleus, PML body 1 MTOR
PML body 1 MTOR
collagen-containing extracellular matrix 2 ANXA5, PKM
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
receptor complex 2 EGFR, RIPK1
Zymogen granule membrane 1 ANXA5
cilium 1 PKM
chromatin 1 NFE2L2
mediator complex 1 NFE2L2
cytoskeleton 1 CASP8
spindle pole 1 MAPK14
blood microparticle 1 SLC2A1
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, NLRP3
microtubule organizing center 1 NLRP3
female germ cell nucleus 1 SLC2A1
Melanosome 1 SLC2A1
cell body 1 CASP8
myelin sheath 1 BCL2
Peroxisome membrane 1 HMGCR
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 MAPK14, PKM
secretory granule lumen 2 MAPK14, PKM
endoplasmic reticulum lumen 1 CD4
cortical actin cytoskeleton 1 SLC2A1
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Single-pass type IV membrane protein 1 HMOX1
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 2 CD4, EGFR
protein-DNA complex 1 NFE2L2
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP8, RIPK1
ripoptosome 2 CASP8, RIPK1
female pronucleus 1 SLC2A1
Rough endoplasmic reticulum 1 PKM
Cytoplasmic vesicle, phagosome 1 MTOR
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
T cell receptor complex 1 CD4
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
glucose transporter complex 1 SLC2A1
[Isoform M2]: Cytoplasm 1 PKM
[Isoform M1]: Cytoplasm 1 PKM
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1


文献列表

  • Wensheng Xie, Ying Li, Zhenhu Guo, Jingsong Lu, Guofeng Li, Ziyao Zhang, Fangming Zhang, Yen Wei, Xing Wang, Lingyun Zhao. FePd Nanozyme- and SKN-Encapsulated Functional Lipid Nanoparticles for Cancer Nanotherapy via ROS-Boosting Necroptosis. ACS applied materials & interfaces. 2024 Apr; 16(15):18411-18421. doi: 10.1021/acsami.3c18497. [PMID: 38584383]
  • Zhuo Chen, Feng-Feng Wu, Jing Li, Jia-Bao Dong, Hong-Yi He, Xiong-Feng Li, Qian Lu, Wen-Xuan Zhang, Chang-Ming Shao, Zhao-Nong Yao, Nong Lin, Zhao-Ming Ye, Jun-Tao Xu, Heng-Yuan Li. Investigating the synergy of Shikonin and Valproic acid in inducing apoptosis of osteosarcoma cells via ROS-mediated EGR1 expression. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155459. doi: 10.1016/j.phymed.2024.155459. [PMID: 38417243]
  • Hongwei Han, Minkai Yang, Zhongling Wen, Xuan Wang, Xiaohui Lai, Yahan Zhang, Rongjun Fang, Tongming Yin, Xiaorong Yang, Xiaoming Wang, Quan Zhao, Jinliang Qi, Hongyuan Chen, Hongyan Lin, Yonghua Yang. A modified natural small molecule inhibits triple-negative breast cancer growth by interacting with Tubb3. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):154894. doi: 10.1016/j.phymed.2023.154894. [PMID: 38377719]
  • Chuanbo Ding, Jiali Yang, Ning Wang, Qiteng Ding, Shuwen Sun, Yang Gao, Liqian Shen, Ting Zhao, Yue Wang. Sodium alginate/polyvinyl alcohol nanofibers loaded with Shikonin for diabetic wound healing: In vivo and in vitro evaluation. International journal of biological macromolecules. 2024 Mar; 262(Pt 1):129937. doi: 10.1016/j.ijbiomac.2024.129937. [PMID: 38325683]
  • Yanyan Zhao, Nebojša Rodić, Marios Liaskos, Andreana N Assimopoulou, Ismahen Lalaymia, Stéphane Declerck. Effects of fungal endophytes and arbuscular mycorrhizal fungi on growth of Echium vulgare and alkannin/shikonin and their derivatives production in roots. Fungal biology. 2024 02; 128(1):1607-1615. doi: 10.1016/j.funbio.2023.12.004. [PMID: 38341266]
  • Ryota Nomura, Yuto Suehiro, Fumikazu Tojo, Saaya Matayoshi, Rena Okawa, Masakazu Hamada, Shuhei Naka, Michiyo Matsumoto-Nakano, Rika Unesaki, Kazuya Koumoto, Keiko Kawauchi, Takahito Nishikata, Tatsuya Akitomo, Chieko Mitsuhata, Masatoshi Yagi, Toshiro Mizoguchi, Koki Fujikawa, Taizo Taniguchi, Kazuhiko Nakano. Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25021075. [PMID: 38256148]
  • Yujia Zhao, Dan Wu, Zhenkai Fu, Wenna Liu, Yu Yao, Ying Liang. Shikonin reactivates TSGs GADD45B and PPP3CC to block NSCLC cell proliferation and migration through JNK/P38/MAPK signaling pathways. BMC complementary medicine and therapies. 2024 Jan; 24(1):10. doi: 10.1186/s12906-023-04306-z. [PMID: 38167059]
  • Xin-Yi Ai, Xue-Feng Hou, Nian-Ping Feng. [Combination of shikonin and gefitinib reverses drug resistance in human non-small cell lung cancer and its mechanism]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Jan; 49(1):175-184. doi: 10.19540/j.cnki.cjcmm.20230810.401. [PMID: 38403350]
  • Haruka Oshikiri, Hao Li, Misaki Manabe, Hirobumi Yamamoto, Kazufumi Yazaki, Kojiro Takanashi. Comparative Analysis of Shikonin and Alkannin Acyltransferases Reveals Their Functional Conservation in Boraginaceae. Plant & cell physiology. 2023 Dec; ?(?):. doi: 10.1093/pcp/pcad158. [PMID: 38181221]
  • Yanping Song, Qiteng Ding, Yuewen Hao, Bing Cui, Chuanbo Ding, Feng Gao. Pharmacological Effects of Shikonin and Its Potential in Skin Repair: A Review. Molecules (Basel, Switzerland). 2023 Dec; 28(24):. doi: 10.3390/molecules28247950. [PMID: 38138440]
  • Manami Inoue, Yuki Nakagawa, Miku Azuma, Haruka Akahane, Ryusei Chimori, Yasunari Mano, Ryoko Takasawa. The PKM2 inhibitor shikonin enhances piceatannol-induced apoptosis of glyoxalase I-dependent cancer cells. Genes to cells : devoted to molecular & cellular mechanisms. 2023 Nov; ?(?):. doi: 10.1111/gtc.13084. [PMID: 37963646]
  • Yan Yue, Yuqing Fang, Ruoyang Jia, Keang Cao, Xue Chen, Hongmei Xia, Zhiqing Cheng. Study on the Antioxidant Effect of Shikonin-Loaded β-Cyclodextrin Forming Host-Guest Complexes That Prevent Skin from Photoaging. International journal of molecular sciences. 2023 Oct; 24(20):. doi: 10.3390/ijms242015177. [PMID: 37894857]
  • Yan Liu, Yue Wang, Jingchun Kong, Xianguo Jiang, Yijia Han, Luozhu Feng, Yao Sun, Lijiang Chen, Tieli Zhou. An effective antimicrobial strategy of colistin combined with the Chinese herbal medicine shikonin against colistin-resistant Escherichia coli. Microbiology spectrum. 2023 Oct; ?(?):e0145923. doi: 10.1128/spectrum.01459-23. [PMID: 37800902]
  • Kirandeep Kaur, Atamjit Singh, Aditi Monga, Pallvi Mohana, Neha Khosla, Neena Bedi. Antimicrobial and antibiofilm effects of shikonin with tea tree oil nanoemulsion against Candida albicans and Staphylococcus aureus. Biofouling. 2023 Oct; 39(9-10):962-979. doi: 10.1080/08927014.2023.2281511. [PMID: 38009008]
  • Chang Liu, Hailong Zhang, Xiaoqian Cui, Shanshan Wang, Quanyu Zhou. The effects of Shikonin on the hypertrophic scar of rabbit ears via the TLR4/NF-κB signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). 2023 Sep; 69(9):161-166. doi: 10.14715/cmb/2023.69.9.24. [PMID: 37807317]
  • Megan Watson, Timoteea Saitis, Rahim Shareef, Christine Harb, Muhaib Lakhani, Zulfiqar Ahmad. Shikonin and Alkannin inhibit ATP synthase and impede the cell growth in Escherichia coli. International journal of biological macromolecules. 2023 Sep; 253(Pt 4):127049. doi: 10.1016/j.ijbiomac.2023.127049. [PMID: 37758110]
  • Chunguang Sun, Lin Liao. Research Progress of the Molecular Mechanism of Antithyroid Cancer Activity of Shikonin. Current molecular pharmacology. 2023 Sep; ?(?):. doi: 10.2174/1874467217666230904104414. [PMID: 37670707]
  • Ryosuke Maeoka, Yukiteru Ouji, Tsutomu Nakazawa, Ryosuke Matsuda, Takayuki Morimoto, Shohei Yokoyama, Shuichi Yamada, Fumihiko Nishimura, Ichiro Nakagawa, Young-Soo Park, Masahide Yoshikawa, Hiroyuki Nakase. Local administration of shikonin improved the overall survival in orthotopic murine glioblastoma models with temozolomide resistance. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115296. doi: 10.1016/j.biopha.2023.115296. [PMID: 37557011]
  • Yudi Ma, Xiaohui Lai, Zhongling Wen, Ziling Zhou, Minkai Yang, Qingqing Chen, Xuan Wang, Feng Mei, Liu Yang, Tongming Yin, Shucun Sun, Guihua Lu, Jinliang Qi, Hongyan Lin, Hongwei Han, Yonghua Yang. Design, synthesis and biological evaluation of novel modified dual-target shikonin derivatives for colorectal cancer treatment. Bioorganic chemistry. 2023 Jun; 139(?):106703. doi: 10.1016/j.bioorg.2023.106703. [PMID: 37399615]
  • Feng Zhu, Zhengyi Song, Shuang Zhang, Xueqin Zhang, Dan Zhu. The Renoprotective Effect of Shikonin in a Rat Model of Diabetic Kidney Disease. Transplantation proceedings. 2023 Jun; ?(?):. doi: 10.1016/j.transproceed.2023.04.039. [PMID: 37391330]
  • Lijia Yuan, Yong Wang, Youlian Chen, Xiaoyin Chen, Shun Li, Xueyan Liu. Shikonin inhibits immune checkpoint PD-L1 expression on macrophage in sepsis by modulating PKM2. International immunopharmacology. 2023 Jun; 121(?):110401. doi: 10.1016/j.intimp.2023.110401. [PMID: 37302371]
  • Xinyu Qian, Lin Zhu, Mengzhen Xu, Haoli Liu, Xinyan Yu, Qiuyue Shao, Jing Qin. Shikonin suppresses small cell lung cancer growth via inducing ATF3-mediated ferroptosis to promote ROS accumulation. Chemico-biological interactions. 2023 May; ?(?):110588. doi: 10.1016/j.cbi.2023.110588. [PMID: 37268198]
  • Toru Hosoi, Kyosuke Yazawa, Michihiro Imada, Akari Tawara, Chihiro Tohda, Yasuyuki Nomura, Koichiro Ozawa. Alkannin Attenuates Amyloid β Aggregation and Alzheimer's Disease Pathology. Molecular pharmacology. 2023 05; 103(5):266-273. doi: 10.1124/molpharm.121.000468. [PMID: 36868792]
  • Hongyan Lin, Hongwei Han, Minkai Yang, Zhongling Wen, Qingqing Chen, Yudi Ma, Xuan Wang, Changyi Wang, Tongming Yin, Xiaoming Wang, Guihua Lu, Hongyuan Chen, Jinliang Qi, Yonghua Yang. PKM2/PDK1 dual-targeted shikonin derivatives restore the sensitivity of EGFR-mutated NSCLC cells to gefitinib by remodeling glucose metabolism. European journal of medicinal chemistry. 2023 Mar; 249(?):115166. doi: 10.1016/j.ejmech.2023.115166. [PMID: 36731272]
  • Ke-Shen Qu, Yi Ru, Dan Yang, Le Kuai, Ying Luo, Ping-An Zhang, Meng Xing, Hua-Fa Que. Fu-Huang ointment ameliorates impaired wound healing associated with diabetes through PI3K-AKT signalling pathway activation. Computers in biology and medicine. 2023 03; 155(?):106660. doi: 10.1016/j.compbiomed.2023.106660. [PMID: 36809697]
  • Sheng Wang, Linyuan Shi, Ruishan Wang, Changzheng Liu, Jinye Wang, Ye Shen, Kanade Tatsumi, Nicolas Navrot, Tan Liu, Lanping Guo. Characterization of Arnebia euchroma PGT homologs involved in the biosynthesis of shikonin. Plant physiology and biochemistry : PPB. 2023 Feb; 196(?):587-595. doi: 10.1016/j.plaphy.2023.02.012. [PMID: 36780721]
  • Maowei Ni, Jie Zhou, Zhihui Zhu, Qiang Xu, Zhuomin Yin, Yifan Wang, Zhiguo Zheng, Huajun Zhao. Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe2+ accumulation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Feb; 112(?):154701. doi: 10.1016/j.phymed.2023.154701. [PMID: 36773431]
  • Xin Zhao, Lei Wang, Meng-Yu Xia, Zai-Chang Yang. Antimycobacterial Compound of Cynoglossum lanceolatum Forsk.: Bioassay Guided Isolation, Molecular Docking, Synthesis of Analogs, and a Plausible Mechanism of Action. Chemistry & biodiversity. 2023 Feb; 20(2):e202200965. doi: 10.1002/cbdv.202200965. [PMID: 36567254]
  • Jie He, Youfa Xie, Junzhen Zhong, Wenrong Chen, Suqiong Fang, Xing Chen, Shengfeng Peng, Wei Liu, Chengmei Liu. Improving shikonin solubility and stability by encapsulation in natural surfactant-coated shikonin nanoparticles. Journal of food science. 2023 Feb; 88(2):825-836. doi: 10.1111/1750-3841.16445. [PMID: 36625167]
  • Fatemeh Ghazagh, Mohammad B Bagherieh-Najjar, Tahereh Nezamdoost. Unraveling the interaction of copper, cadmium, calcium, and nitrate on phenolics, flavonoids, and shikonin contents of Onosma dichroantha calli by statistical modeling. Environmental science and pollution research international. 2023 Jan; ?(?):. doi: 10.1007/s11356-023-25187-2. [PMID: 36662436]
  • Kanade Tatsumi, Takuji Ichino, Natsumi Isaka, Akifumi Sugiyama, Eiko Moriyoshi, Yozo Okazaki, Yasuhiro Higashi, Masataka Kajikawa, Yoshinori Tsuji, Hideya Fukuzawa, Kiminori Toyooka, Mayuko Sato, Ikuyo Ichi, Koichiro Shimomura, Hiroyuki Ohta, Kazuki Saito, Kazufumi Yazaki. Excretion of triacylglycerol as a matrix lipid facilitating apoplastic accumulation of a lipophilic metabolite shikonin. Journal of experimental botany. 2023 01; 74(1):104-117. doi: 10.1093/jxb/erac405. [PMID: 36223279]
  • Chunmei Yan, Qiuxia Li, Qiang Sun, Lu Yang, Xing Liu, Yuxin Zhao, Mingyi Shi, Xiaofang Li, Kaipei Luo. Promising Nanomedicines of Shikonin for Cancer Therapy. International journal of nanomedicine. 2023; 18(?):1195-1218. doi: 10.2147/ijn.s401570. [PMID: 36926681]
  • Abdulhakeem Olarewaju Sulyman, Oluwapelumi Oluwaseun Aje, Emmanuel Oladipo Ajani, Rukayat Abiola Abdulsalam, Fatai Oladunni Balogun, Saheed Sabiu. Bioprospection of Selected Plant Secondary Metabolites as Modulators of the Proteolytic Activity of Plasmodium falciparum Plasmepsin V. BioMed research international. 2023; 2023(?):6229503. doi: 10.1155/2023/6229503. [PMID: 37388365]
  • H E Lianhua, Luan Huijie, Qin Qingxia, H E Juan, Chen Jian, H U Yiping, Cai Yueming, Sun Desheng, Shi Yu, Wang Qingwen. Shikonin alleviates collagen-induced arthritis mice by inhibiting M1 macrophage polarization. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 12; 42(6):932-939. doi: 10.19852/j.cnki.jtcm.20220815.004. [PMID: 36378051]
  • Qingqing Chen, Hongwei Han, Faxiang Lin, Liangjie Yang, Lu Feng, Xiaohui Lai, Zhongling Wen, Minkai Yang, Changyi Wang, Yudi Ma, Tongming Yin, Guihua Lu, Hongyan Lin, Jinliang Qi, Yonghua Yang. Novel shikonin derivatives suppress cell proliferation, migration and induce apoptosis in human triple-negative breast cancer cells via regulating PDK1/PDHC axis. Life sciences. 2022 Dec; 310(?):121077. doi: 10.1016/j.lfs.2022.121077. [PMID: 36244412]
  • Juewen Feng, Yanbing Wang, Yingni Lv, Siqi Fang, Mengjiao Ren, Min Yao, Minbo Lan, Yuzheng Zhao, Feng Gao. XA pH-Responsive and Colitis-Targeted Nanoparticle Loaded with Shikonin for the Oral Treatment of Inflammatory Bowel Disease in Mice. Molecular pharmaceutics. 2022 11; 19(11):4157-4170. doi: 10.1021/acs.molpharmaceut.2c00550. [PMID: 36106774]
  • Cintia Csorba, Nebojša Rodić, Yanyan Zhao, Livio Antonielli, Günter Brader, Angeliki Vlachou, Evangelia Tsiokanos, Ismahen Lalaymia, Stéphane Declerck, Vassilios P Papageorgiou, Andreana N Assimopoulou, Angela Sessitsch. Metabolite Production in Alkanna tinctoria Links Plant Development with the Recruitment of Individual Members of Microbiome Thriving at the Root-Soil Interface. mSystems. 2022 10; 7(5):e0045122. doi: 10.1128/msystems.00451-22. [PMID: 36069453]
  • Muhammad Ahmad, Alicia Varela Alonso, Antigoni E Koletti, Nebojša Rodić, Michael Reichelt, Philipp Rödel, Andreana N Assimopoulou, Ovidiu Paun, Stéphane Declerck, Carolin Schneider, Eva M Molin. Dynamics of alkannin/shikonin biosynthesis in response to jasmonate and salicylic acid in Lithospermum officinale. Scientific reports. 2022 10; 12(1):17093. doi: 10.1038/s41598-022-21322-0. [PMID: 36224205]
  • Hongyan Lin, Xiaopeng Ma, Xiaorong Yang, Qingqing Chen, Zhongling Wen, Minkai Yang, Jiangyan Fu, Tongming Yin, Guihua Lu, Jinliang Qi, Hongwei Han, Yonghua Yang. Natural shikonin and acetyl-shikonin improve intestinal microbial and protein composition to alleviate colitis-associated colorectal cancer. International immunopharmacology. 2022 Oct; 111(?):109097. doi: 10.1016/j.intimp.2022.109097. [PMID: 35952517]
  • Wenjie Feng, Wanrui Shi, Ze Wang, Yanqi Cui, Xinxin Shao, Shuwei Liu, Li Rong, Yi Liu, Hao Zhang. Enhancing Tumor Therapy of Fe(III)-Shikonin Supramolecular Nanomedicine via Triple Ferroptosis Amplification. ACS applied materials & interfaces. 2022 Aug; 14(33):37540-37552. doi: 10.1021/acsami.2c11130. [PMID: 35944147]
  • Yanqin Peng, Yuan Li, Hao Li, Junhua Yu. Shikonin attenuates kidney tubular epithelial cells apoptosis, oxidative stress, and inflammatory response through nicotinamide adenine dinucleotide phosphate oxidase 4/PTEN pathway in acute kidney injury of sepsis model. Drug development research. 2022 08; 83(5):1111-1124. doi: 10.1002/ddr.21936. [PMID: 35417044]
  • Anquan Wang, Sheng Fang, Lin Zhong, Ming Lu, Hongxiang Zhou, Wei Huang, Lei Li, Weilu Gao, Zongsheng Yin. Shikonin, a promising therapeutic drug for osteoarthritis that acts via autophagy activation. International immunopharmacology. 2022 May; 106(?):108563. doi: 10.1016/j.intimp.2022.108563. [PMID: 35176588]
  • Yitian Dai, Yuping Liu, Jingyi Li, Mingming Jin, Hao Yang, Gang Huang. Shikonin inhibited glycolysis and sensitized cisplatin treatment in non-small cell lung cancer cells via the exosomal pyruvate kinase M2 pathway. Bioengineered. 2022 05; 13(5):13906-13918. doi: 10.1080/21655979.2022.2086378. [PMID: 35706397]
  • Wenjing Ji, Xiaoyan Sun, Yang Gao, Man Lu, Lingxia Zhu, Dawei Wang, Chunping Hu, Jiao Chen, Peng Cao. Natural Compound Shikonin Is a Novel PAK1 Inhibitor and Enhances Efficacy of Chemotherapy against Pancreatic Cancer Cells. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092747. [PMID: 35566098]
  • Tingjun Tao, Yan Chen, Bochen Lai, Jinhua Wang, Weiliang Wang, Weimian Xiao, Xushan Cha. Shikonin combined with methotrexate regulate macrophage polarization to treat psoriasis. Bioengineered. 2022 04; 13(4):11146-11155. doi: 10.1080/21655979.2022.2062090. [PMID: 35485255]
  • Ji Li, Ming Zhao, Wendi Liang, Siwen Wu, Zheran Wang, Dongkai Wang. Codelivery of Shikonin and siTGF-β for enhanced triple negative breast cancer chemo-immunotherapy. Journal of controlled release : official journal of the Controlled Release Society. 2022 02; 342(?):308-320. doi: 10.1016/j.jconrel.2022.01.015. [PMID: 35031387]
  • Min Yao, Gan Li, Long-Yun Zhou, Zhong Zheng, Yue-Li Sun, Shu-Fen Liu, Yong-Jun Wang, Xue-Jun Cui. Shikonin inhibits neuronal apoptosis via regulating endoplasmic reticulum stress in the rat model of double-level chronic cervical cord compression. Cell biology and toxicology. 2022 Jan; ?(?):. doi: 10.1007/s10565-021-09648-3. [PMID: 35028790]
  • Yuling Lai, Fuling Zeng, Zhenyue Chen, Min Feng, Yanxi Huang, Pin Qiu, Lihua Zeng, Yan Ke, Gaopi Deng, Jie Gao. Shikonin Could Be Used to Treat Tubal Pregnancy via Enhancing Ferroptosis Sensitivity. Drug design, development and therapy. 2022; 16(?):2083-2099. doi: 10.2147/dddt.s364441. [PMID: 35800255]
  • Qiang Sun, Ting Gong, Maolun Liu, Shan Ren, Han Yang, Sha Zeng, Hui Zhao, Li Chen, Tianqi Ming, Xianli Meng, Haibo Xu. Shikonin, a naphthalene ingredient: Therapeutic actions, pharmacokinetics, toxicology, clinical trials and pharmaceutical researches. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 94(?):153805. doi: 10.1016/j.phymed.2021.153805. [PMID: 34749177]
  • Zefeng Wang, Qianfei Cui, Ling Shi, Meiling Zhang, Peng Song, Dongzhu Duan, Wenjing Guo. Network Pharmacology-based Prediction and Verification of Shikonin for Treating Colorectal Cancer. Recent patents on anti-cancer drug discovery. 2022; 17(3):297-311. doi: 10.2174/1574892817666211224142100. [PMID: 34951580]
  • Jiahua Cui, Jinping Jia. Discovery of juglone and its derivatives as potent SARS-CoV-2 main proteinase inhibitors. European journal of medicinal chemistry. 2021 Dec; 225(?):113789. doi: 10.1016/j.ejmech.2021.113789. [PMID: 34438124]
  • Tian Lan, Ping Fang, Xuemei Ye, Xia Lan, Ren-Ai Xu. Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS. Pharmaceutical biology. 2021 Dec; 59(1):1133-1138. doi: 10.1080/13880209.2021.1964544. [PMID: 34410882]
  • Jiahui Li, Jinglong Pang, Zhe Liu, XianMing Ge, Yanan Zhen, Chen Chen Jiang, Yaming Liu, Qiang Huo, Yiming Sun, Hao Liu. Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways. Scientific reports. 2021 09; 11(1):18263. doi: 10.1038/s41598-021-97713-6. [PMID: 34521930]
  • Liying Sha, Zhiqiang Lv, Yujun Liu, Yun Zhang, Xin Sui, Teng Wang, Hui Zhang. Shikonin inhibits the Warburg effect, cell proliferation, invasion and migration by downregulating PFKFB2 expression in lung cancer. Molecular medicine reports. 2021 Aug; 24(2):. doi: 10.3892/mmr.2021.12199. [PMID: 34109434]
  • Hong Wang, Wanghao Chen, Guojian Wu, Jun Kong, Shaofei Yuan, Lukui Chen. A Magnetic T7 Peptide&AS1411 Aptamer-Modified Microemulsion for Triple Glioma-Targeted Delivery of Shikonin and Docetaxel. Journal of pharmaceutical sciences. 2021 08; 110(8):2946-2954. doi: 10.1016/j.xphs.2021.03.018. [PMID: 33785350]
  • Xiao Yang, Weijing Fan, Renyan Huang, Guobin Liu. β-acetoxyisovaleryl alkannin (AAN-II) from Alkanna tinctoria promotes the healing of pressure-induced venous ulcers in a rabbit model through the activation of TGF-β/Smad3 signaling. Cellular & molecular biology letters. 2021 Jul; 26(1):35. doi: 10.1186/s11658-021-00278-5. [PMID: 34332546]
  • Yingying Ma, Xiaorong Yang, Hongwei Han, Zhongling Wen, Minkai Yang, Yahan Zhang, Jiangyan Fu, Xuan Wang, Tongming Yin, Guihua Lu, Jinliang Qi, Hongyan Lin, Xiaoming Wang, Yonghua Yang. Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway. Bioorganic chemistry. 2021 06; 111(?):104872. doi: 10.1016/j.bioorg.2021.104872. [PMID: 33838560]
  • Aliya Fazal, Minkai Yang, Zhongling Wen, Farman Ali, Ran Ren, Chenyu Hao, Xingyu Chen, Jiangyan Fu, Xuan Wang, Wencai Jie, Tongming Yin, Guihua Lu, Jinliang Qi, Yonghua Yang. Differential microbial assemblages associated with shikonin-producing Borage species in two distinct soil types. Scientific reports. 2021 05; 11(1):10788. doi: 10.1038/s41598-021-90251-1. [PMID: 34031500]
  • Wan Song, Yibin Zhuang, Tao Liu. CYP82AR Subfamily Proteins Catalyze C-1' Hydroxylations of Deoxyshikonin in the Biosynthesis of Shikonin and Alkannin. Organic letters. 2021 04; 23(7):2455-2459. doi: 10.1021/acs.orglett.1c00360. [PMID: 33728922]
  • Ji Li, Ming Zhao, Yunhua Xu, Xiaoyun Hu, Yinghui Dai, Dongkai Wang. Hybrid micelles codelivering shikonin and IDO-1 siRNA enhance immunotherapy by remodeling immunosuppressive tumor microenvironment. International journal of pharmaceutics. 2021 Mar; 597(?):120310. doi: 10.1016/j.ijpharm.2021.120310. [PMID: 33540035]
  • Ramona Figat, Anna Zgadzaj, Sylwia Geschke, Patrycja Sieczka, Agnieszka Pietrosiuk, Sylwester Sommer, Agata Skrzypczak. Cytotoxicity and antigenotoxicity evaluation of acetylshikonin and shikonin. Drug and chemical toxicology. 2021 Mar; 44(2):140-147. doi: 10.1080/01480545.2018.1536710. [PMID: 30574814]
  • Camilla Servidio, Francesco Stellacci. Therapeutic approaches against coronaviruses acute respiratory syndrome. Pharmacology research & perspectives. 2021 02; 9(1):e00691. doi: 10.1002/prp2.691. [PMID: 33378565]
  • Qiang Wu, Aga Er-Bu, Xiaoxia Liang, Shangxian Luan, Changliang He, Lizi Yin, Zhongqiong Yin, Yuanfeng Zou, Lixia Li, Xu Song. Determination of the main naphthoquinones in Onosma hookeri Clarke. var. longiforum Duthie and its optimization of the ultrasound-assisted extraction using response surface methodology. Journal of food science. 2021 Feb; 86(2):357-365. doi: 10.1111/1750-3841.15460. [PMID: 32984979]
  • Yang Chen, Leting Si, Jinghui Zhang, Hengyuan Yu, Xuesong Liu, Yong Chen, Yongjiang Wu. Uncovering the antitumor effects and mechanisms of Shikonin against colon cancer on comprehensive analysis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Feb; 82(?):153460. doi: 10.1016/j.phymed.2021.153460. [PMID: 33476976]
  • Jae Han Lee, So Hee Han, You Min Kim, Sung Hyun Kim, Eun Seon Yoo, Joong Seok Woo, Gi Hwan Jung, Soo Hyun Jung, Bum Seok Kim, Ji Youn Jung. Shikonin inhibits proliferation of melanoma cells by MAPK pathway-mediated induction of apoptosis. Bioscience reports. 2021 01; 41(1):. doi: 10.1042/bsr20203834. [PMID: 33403388]
  • Zhenzhen Mu, Jinrong Guo, Dongxia Zhang, Yuanyuan Xu, Mingming Zhou, Yimeng Guo, Yuzhu Hou, Xinghua Gao, Xiuping Han, Long Geng. Therapeutic Effects of Shikonin on Skin Diseases: A Review. The American journal of Chinese medicine. 2021; 49(8):1871-1895. doi: 10.1142/s0192415x21500889. [PMID: 34961421]
  • Fangfang Xu, Pan Wang, Xiuli Zhang, Tao Hou, Lala Qu, Chaoran Wang, Jixia Wang, Yanfang Liu, Xinmiao Liang. Identification and target-pathway deconvolution of FFA4 agonists with anti-diabetic activity from Arnebia euchroma (Royle) Johnst. Pharmacological research. 2021 01; 163(?):105173. doi: 10.1016/j.phrs.2020.105173. [PMID: 33027715]
  • Chang Liu, Li-Qian Xuan, Kai Li, Zhuo Feng, Chan Lv, Xing-Jia Li, Xiao-Dan Ji, Rong Wan, Jie Shen. Shikonin Inhibits Cholangiocarcinoma Cell Line QBC939 by Regulating Apoptosis, Proliferation, and Invasion. Cell transplantation. 2021 Jan; 30(?):963689720979162. doi: 10.1177/0963689720979162. [PMID: 33508949]
  • Ji Li, Ming Zhao, Meng Sun, Siwen Wu, Hongyan Zhang, Yinghui Dai, Dongkai Wang. Multifunctional Nanoparticles Boost Cancer Immunotherapy Based on Modulating the Immunosuppressive Tumor Microenvironment. ACS applied materials & interfaces. 2020 Nov; 12(45):50734-50747. doi: 10.1021/acsami.0c14909. [PMID: 33124808]
  • Weijia Yang, Minchun Yang, Hui Yao, Yelin Ma, Xuanxuan Ren, Long Teng, Tao Wang. Effects of shikonin from Zicao on high-fat diet-induced nonalcoholic fatty liver disease in rats. Pakistan journal of pharmaceutical sciences. 2020 Nov; 33(6):2527-2533. doi: . [PMID: 33867326]
  • Haruka Oshikiri, Bunta Watanabe, Hirobumi Yamamoto, Kazufumi Yazaki, Kojiro Takanashi. Two BAHD Acyltransferases Catalyze the Last Step in the Shikonin/Alkannin Biosynthetic Pathway. Plant physiology. 2020 10; 184(2):753-761. doi: 10.1104/pp.20.00207. [PMID: 32727911]
  • Hirobumi Yamamoto, Mika Tsukahara, Yumiko Yamano, Akimori Wada, Kazufumi Yazaki. Alcohol Dehydrogenase Activity Converts 3″-Hydroxy-geranylhydroquinone to an Aldehyde Intermediate for Shikonin and Benzoquinone Derivatives in Lithospermum erythrorhizon. Plant & cell physiology. 2020 Oct; 61(10):1798-1806. doi: 10.1093/pcp/pcaa108. [PMID: 32810231]
  • Qianwen Zheng, Qin Li, Gang Zhao, Jie Zhang, Hang Yuan, Di Gong, Yafei Guo, Xinhua Liu, Kai Li, Ping Lin. Alkannin induces cytotoxic autophagy and apoptosis by promoting ROS-mediated mitochondrial dysfunction and activation of JNK pathway. Biochemical pharmacology. 2020 10; 180(?):114167. doi: 10.1016/j.bcp.2020.114167. [PMID: 32702370]
  • Chen Zhong, Qin Yu, Wentao Jia, Xin Yu, Dandan Yu, Ming Yang, Lina Wang, Changquan Ling, Liqing Zhu. Mechanism for enhanced transduction of hematopoietic cells by recombinant adeno-associated virus serotype 6 vectors. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 09; 34(9):12379-12391. doi: 10.1096/fj.201902875r. [PMID: 32960474]
  • Yang Chen, Juan Ni, Yun Gao, Jinghui Zhang, Xuesong Liu, Yong Chen, Zhongjian Chen, Yongjiang Wu. Integrated proteomics and metabolomics reveals the comprehensive characterization of antitumor mechanism underlying Shikonin on colon cancer patient-derived xenograft model. Scientific reports. 2020 08; 10(1):14092. doi: 10.1038/s41598-020-71116-5. [PMID: 32839531]
  • G Warnes. Flow cytometric detection of hyper-polarized mitochondria in regulated and accidental cell death processes. Apoptosis : an international journal on programmed cell death. 2020 08; 25(7-8):548-557. doi: 10.1007/s10495-020-01613-5. [PMID: 32495124]
  • Wan Song, Yibin Zhuang, Tao Liu. Potential role of two cytochrome P450s obtained from Lithospermum erythrorhizon in catalyzing the oxidation of geranylhydroquinone during Shikonin biosynthesis. Phytochemistry. 2020 Jul; 175(?):112375. doi: 10.1016/j.phytochem.2020.112375. [PMID: 32305685]
  • Merve Yuzbasioglu Baran, Zuhal Guvenalp, Iclal Saracoglu, Cavit Kazaz, Bekir Salih, L Omur Demirezer, Ayse Kuruuzum-Uz. Cytotoxic naphthoquinones from Arnebia densiflora (Nordm.) Ledeb and determining new apoptosis inducers. Natural product research. 2020 Jun; 34(12):1669-1677. doi: 10.1080/14786419.2018.1525714. [PMID: 30449173]
  • So Young Gwon, Jiyun Ahn, Chang Hwa Jung, BoKyung Moon, Tae-Youl Ha. Shikonin Attenuates Hepatic Steatosis by Enhancing Beta Oxidation and Energy Expenditure via AMPK Activation. Nutrients. 2020 Apr; 12(4):. doi: 10.3390/nu12041133. [PMID: 32316687]
  • Hayato Ueoka, Kanako Sasaki, Tatsuya Miyawaki, Takuji Ichino, Kanade Tatsumi, Shiro Suzuki, Hirobumi Yamamoto, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Kazufumi Yazaki. A Cytosol-Localized Geranyl Diphosphate Synthase from Lithospermum erythrorhizon and Its Molecular Evolution. Plant physiology. 2020 04; 182(4):1933-1945. doi: 10.1104/pp.19.00999. [PMID: 31974127]
  • Shannon R Sweeney, Meghan Collins, Renu Pandey, Jennifer Chiou, Alessia Lodi, Stefano Tiziani. Identification of a synergistic combination of dimethylaminoparthenolide and shikonin alters metabolism and inhibits proliferation of pediatric precursor-B cell acute lymphoblastic leukemia. Molecular carcinogenesis. 2020 04; 59(4):399-411. doi: 10.1002/mc.23163. [PMID: 32027051]
  • Ying Ying Zhang, Xue Liu, Xiaojie Zhang, Jingjing Zhang. Shikonin improve sepsis-induced lung injury via regulation of miRNA-140-5p/TLR4-a vitro and vivo study. Journal of cellular biochemistry. 2020 03; 121(3):2103-2117. doi: 10.1002/jcb.28199. [PMID: 31769066]
  • Cheng-Long Gao, Gui-Ge Hou, Jin Liu, Tong Ru, Ya-Zhou Xu, Shun-Yi Zhao, Hui Ye, Lu-Yong Zhang, Kai-Xian Chen, Yue-Wei Guo, Tao Pang, Xu-Wen Li. Synthesis and Target Identification of Benzoxepane Derivatives as Potential Anti-Neuroinflammatory Agents for Ischemic Stroke. Angewandte Chemie (International ed. in English). 2020 02; 59(6):2429-2439. doi: 10.1002/anie.201912489. [PMID: 31782597]
  • Andrew D James, Daniel A Richardson, In-Whan Oh, Pishyaporn Sritangos, Thomas Attard, Lisa Barrett, Jason I E Bruce. Cutting off the fuel supply to calcium pumps in pancreatic cancer cells: role of pyruvate kinase-M2 (PKM2). British journal of cancer. 2020 01; 122(2):266-278. doi: 10.1038/s41416-019-0675-3. [PMID: 31819190]
  • Mei Liao, Pan Yan, Xuechen Liu, Zhifeng Du, Shuailong Jia, Rahmetulla Aybek, Aiqian Li, Sulaiman Kaisa, Hongliang Jiang. Spectrum-effect relationship for anti-tumor activity of shikonins and shikonofurans in medicinal Zicao by UHPLC-MS/MS and chemometric approaches. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jan; 1136(?):121924. doi: 10.1016/j.jchromb.2019.121924. [PMID: 31841980]
  • Nan Zhang, Fu Peng, Yujia Wang, Li Yang, Fengbo Wu, Xiaoyun Wang, Cui Ye, Bo Han, Gu He. Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis. International journal of biological sciences. 2020; 16(1):147-161. doi: 10.7150/ijbs.36955. [PMID: 31892852]
  • Qing Tang, Lihua Liu, Hongyan Zhang, Jing Xiao, Swei Sunny Hann. Regulations of miR-183-5p and Snail-Mediated Shikonin-Reduced Epithelial-Mesenchymal Transition in Cervical Cancer Cells. Drug design, development and therapy. 2020; 14(?):577-589. doi: 10.2147/dddt.s236216. [PMID: 32103900]
  • Cheng-Yi Tang, Song Li, Yun-Tong Wang, Xi Wang. Comparative genome/transcriptome analysis probes Boraginales' phylogenetic position, WGDs in Boraginales, and key enzyme genes in the alkannin/shikonin core pathway. Molecular ecology resources. 2020 Jan; 20(1):228-241. doi: 10.1111/1755-0998.13104. [PMID: 31625679]
  • Saeed Mollaei, Omid Khanehbarndaz, Zahra Gerami-Khashal, Mostafa Ebadi. Molecular identification and phytochemical screening of endophytic fungi isolated from Lithospermum officinale L. roots: A new source of shikonin. Phytochemistry. 2019 Dec; 168(?):112116. doi: 10.1016/j.phytochem.2019.112116. [PMID: 31513947]
  • Wen-Xue Sun, Hong-Wei Han, Min-Kai Yang, Zhong-Ling Wen, Yin-Song Wang, Jiang-Yan Fu, Yun-Ting Lu, Ming-Yue Wang, Jia-Xin Bao, Gui-Hua Lu, Jin-Liang Qi, Xiao-Ming Wang, Hong-Yan Lin, Yong-Hua Yang. Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR. Bioorganic & medicinal chemistry. 2019 12; 27(23):115153. doi: 10.1016/j.bmc.2019.115153. [PMID: 31648877]
  • Yongkang Liu, Xing Kang, Geng Niu, Senlin He, Tingting Zhang, Yuwei Bai, Yi Li, Houyan Hao, Chao Chen, Zhexing Shou, Bin Li. Shikonin induces apoptosis and prosurvival autophagy in human melanoma A375 cells via ROS-mediated ER stress and p38 pathways. Artificial cells, nanomedicine, and biotechnology. 2019 Dec; 47(1):626-635. doi: 10.1080/21691401.2019.1575229. [PMID: 30873870]
  • Liushun Jia, Zhen Zhu, Hongbo Li, Yaofeng Li. Shikonin inhibits proliferation, migration, invasion and promotes apoptosis in NCI-N87 cells via inhibition of PI3K/AKT signal pathway. Artificial cells, nanomedicine, and biotechnology. 2019 Dec; 47(1):2662-2669. doi: 10.1080/21691401.2019.1632870. [PMID: 31257936]
  • Yang Yang, Wenya Gao, Shiying Tao, Yanxia Wang, Jianzhao Niu, Piwen Zhao, Chenchen Rao, Lei Yang. ER-mediated anti-tumor effects of shikonin on breast cancer. European journal of pharmacology. 2019 Nov; 863(?):172667. doi: 10.1016/j.ejphar.2019.172667. [PMID: 31545985]
  • Nisansala Chandimali, Hu-Nan Sun, Ling-Zu Kong, Xing Zhen, Ren Liu, Taeho Kwon, Dong-Sun Lee. Shikonin-induced Apoptosis of Colon Cancer Cells Is Reduced by Peroxiredoxin V Expression. Anticancer research. 2019 Nov; 39(11):6115-6123. doi: 10.21873/anticanres.13819. [PMID: 31704839]
  • Mohammed Alquraishi, Dexter L Puckett, Dina S Alani, Amal S Humidat, Victoria D Frankel, Dallas R Donohoe, Jay Whelan, Ahmed Bettaieb. Pyruvate kinase M2: A simple molecule with complex functions. Free radical biology & medicine. 2019 11; 143(?):176-192. doi: 10.1016/j.freeradbiomed.2019.08.007. [PMID: 31401304]
  • Hong Wang, Zhihan Zhu, Guilong Zhang, Feixiang Lin, Yong Liu, Yu Zhang, Jia Feng, Wanghao Chen, Qiang Meng, Lukui Chen. AS1411 Aptamer/Hyaluronic Acid-Bifunctionalized Microemulsion Co-Loading Shikonin and Docetaxel for Enhanced Antiglioma Therapy. Journal of pharmaceutical sciences. 2019 11; 108(11):3684-3694. doi: 10.1016/j.xphs.2019.08.017. [PMID: 31465736]
  • Chuanjie Guo, Junlin He, Xiaominting Song, Lu Tan, Miao Wang, Peidu Jiang, Yuzhi Li, Zhixing Cao, Cheng Peng. Pharmacological properties and derivatives of shikonin-A review in recent years. Pharmacological research. 2019 11; 149(?):104463. doi: 10.1016/j.phrs.2019.104463. [PMID: 31553936]
  • Ambreen Shoaib, Rakesh Kumar Dixit, Badruddeen, Md Azizur Rahman, Paramdeep Bagga, Sarjeel Kaleem, Sahabjada Siddiqui, Md Arshad, Hefazat Hussain Siddiqui. Cure of human diabetic neuropathy by HPLC validated bark extract of Onosma echioides L. root. Natural product research. 2019 Sep; 33(18):2699-2703. doi: 10.1080/14786419.2018.1460838. [PMID: 29629826]
  • Dominik Skoneczny, Xiaocheng Zhu, Paul A Weston, Geoff M Gurr, Ragan M Callaway, Leslie A Weston. Production of pyrrolizidine alkaloids and shikonins in Echium plantagineum L. in response to various plant stressors. Pest management science. 2019 Sep; 75(9):2530-2541. doi: 10.1002/ps.5540. [PMID: 31267648]