METHIONINE (BioDeep_00000229632)
Main id: BioDeep_00000398114
human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019
描述信息
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
L-Methionine is the L-isomer of Methionine, an essential amino acid for human development. Methionine acts as a hepatoprotectant.
同义名列表
5 个代谢物同义名
poly-l-methionine; L-Methionine; METHIONINE; L-Methionine; L-Methionine
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:16643
- KEGG: C00073
- PubChem: 6137
- HMDB: HMDB00696
- DrugBank: DB00134
- ChEMBL: CHEMBL42336
- MeSH: Methionine
- CAS: 1006386-95-3
- CAS: 26062-47-5
- CAS: 58576-49-1
- CAS: 3654-96-4
- CAS: 63-68-3
- MoNA: MT000102
- PubChem: 3373
- KNApSAcK: C00001379
- PDB-CCD: MET
- 3DMET: B01148
- NIKKAJI: J9.174J
- RefMet: Methionine
- medchemexpress: HY-N0326
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-768
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-38
- KNApSAcK: 16643
分类词条
相关代谢途径
Reactome(0)
BioCyc(14)
- tRNA charging pathway
- methionine biosynthesis
- superpathway of lysine, threonine and methionine biosynthesis II
- superpathway of lysine, threonine and methionine biosynthesis I
- formylTHF biosynthesis II
- formylTHF biosynthesis I
- methionine biosynthesis II
- methionine biosynthesis I
- heme biosynthesis from uroporphyrinogen-III II
- methionine and S-adenosylmethionine synthesis
- folate metabolism
- S-adenosylmethionine cycle
- biotin biosynthesis
- S-adenosylmethionine biosynthesis
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
7 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhi Ma, Kaihong Xie, Xiaoyong Xue, Jianan Li, Yang Yang, Jianzhi Wu, Yufei Li, Xiaojiaoyang Li. Si-Wu-Tang attenuates hepatocyte PANoptosis and M1 polarization of macrophages in non-alcoholic fatty liver disease by influencing the intercellular transfer of mtDNA.
Journal of ethnopharmacology.
2024 Jun; 328(?):118057. doi:
10.1016/j.jep.2024.118057. [PMID: 38518965] - Ewa Marzena Kalemba, Kris Gevaert, Francis Impens, Sara Dufour, Anna Czerwoniec. The association of protein-bound methionine sulfoxide with proteomic basis for aging in beech seeds.
BMC plant biology.
2024 May; 24(1):377. doi:
10.1186/s12870-024-05085-6. [PMID: 38714916] - Xing Jin, Lei Liu, Dan Liu, Jia Wu, Congcong Wang, Siliang Wang, Fengying Wang, Guanzhen Yu, Xiaoxia Jin, Yu-Wen Xue, Dan Jiang, Yan Ni, Xi Yang, Ming-Song Wang, Zhi-Wei Wang, Yuriy L Orlov, Wei Jia, Gerry Melino, Ji-Bin Liu, Wen-Lian Chen. Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma.
Cell death and differentiation.
2024 May; 31(5):558-573. doi:
10.1038/s41418-024-01285-7. [PMID: 38570607] - M Klünemann, L F Romero, M Acman, M C Milfort, A L Fuller, R Rekaya, S E Aggrey, L M Payling, A Lemme. Multitissue transcriptomics demonstrates the systemic physiology of methionine deficiency in broiler chickens.
Animal : an international journal of animal bioscience.
2024 May; 18(5):101143. doi:
10.1016/j.animal.2024.101143. [PMID: 38640782] - Li-Chan Yang, Chih-Chiang Wang, Der-Yen Lee, Wen-Chuan Lin, Sheng-Chu Kuo, Shin-Hun Juang, Min-Tsang Hsieh. 4,4-Diallyl curcumin bis(2,2-hydroxymethyl)propanoate ameliorates nonalcoholic steatohepatitis in methionine-choline-deficient diet and Western diet mouse models.
Chemical biology & drug design.
2024 May; 103(5):e14532. doi:
10.1111/cbdd.14532. [PMID: 38725089] - Yang Liu, Tuo Li, Han Zhu, Linhua Cao, Lebin Liang, Dongyang Liu, Qirong Shen. Methionine inducing carbohydrate esterase secretion of Trichoderma harzianum enhances the accessibility of substrate glycosidic bonds.
Microbial cell factories.
2024 Apr; 23(1):120. doi:
10.1186/s12934-024-02394-1. [PMID: 38664812] - Meng Liu, Li He. Dietary cysteine and methionine promote peroxisome elevation and fat loss by induction of CG33474 expression in Drosophila adipose tissue.
Cellular and molecular life sciences : CMLS.
2024 Apr; 81(1):190. doi:
10.1007/s00018-024-05226-y. [PMID: 38649521] - Chaofeng Wu, Junjie Li, Hui Jia, Jiamin Zhao, Mengchen Qin, Hao Shi, Chang Liu, Jiajie Lin, Min Cai, Yong Gu, Bin Liu, Lei Gao. Indoleamine 2,3-dioxygenase 1-mediated iron metabolism in macrophages contributes to lipid deposition in nonalcoholic steatohepatitis.
Journal of gastroenterology.
2024 04; 59(4):342-356. doi:
10.1007/s00535-024-02082-2. [PMID: 38402297] - Yi-Fei Nie, Jia-Ming Shang, Duan-Qin Liu, Wen-Qing Meng, Hui-Ping Ren, Chuan-Hua Li, Zhi-Feng Wang, Jing Lan. Apical papilla stem cell-derived exosomes regulate lipid metabolism and alleviate inflammation in the MCD-induced mouse NASH model.
Biochemical pharmacology.
2024 Apr; 222(?):116073. doi:
10.1016/j.bcp.2024.116073. [PMID: 38395263] - Joyati Das, Srayan Ghosh, Kriti Tyagi, Debashis Sahoo, Gopaljee Jha. Methionine biosynthetic genes and methionine sulfoxide reductase A are required for Rhizoctonia solani AG1-IA to cause sheath blight disease in rice.
Microbial biotechnology.
2024 Apr; 17(4):e14441. doi:
10.1111/1751-7915.14441. [PMID: 38568774] - Jie Yang, Manyun Dai, Ying Wang, Zheng Yan, Shuqi Mao, Aiming Liu, Caide Lu. A CDAHFD-induced mouse model mimicking human NASH in the metabolism of hepatic phosphatidylcholines and acyl carnitines.
Food & function.
2024 Mar; 15(6):2982-2995. doi:
10.1039/d3fo05111k. [PMID: 38411344] - Mengqi Zhang, Xiaofeng Shi, Minglei Tang, Wen Yin, Cheng Luo, Xiangyang Xie. PRDX2 deficiency increases MCD-induced nonalcoholic steatohepatitis in female mice.
Biochemical and biophysical research communications.
2024 Mar; 701(?):149589. doi:
10.1016/j.bbrc.2024.149589. [PMID: 38309152] - Yunying Huang, Qiuzhen Lin, Yong Zhou, Jiayi Zhu, Yingxu Ma, Keke Wu, Zuodong Ning, Zixi Zhang, Na Liu, Mohan Li, Yaozhong Liu, Tao Tu, Qiming Liu. Amino acid profile alteration in age-related atrial fibrillation.
Journal of translational medicine.
2024 Mar; 22(1):259. doi:
10.1186/s12967-024-05028-7. [PMID: 38461346] - Vandana Sekhar, Houssine Ikhlef, Alexandra Bunea, Viet S Nguyen, Johan Joo, Mukund P Tantak, Holly Moots, Otto Phanstiel. The Development of LAT1 Efflux Agonists as Mechanistic Probes of Cellular Amino Acid Stress.
Biomolecules.
2024 Mar; 14(3):. doi:
10.3390/biom14030326. [PMID: 38540746] - Mei-Ting Tai, Chen-Fang Zhang, Chao-Wen Fan, Wei-Yi Tian, Qi Yu, Yan Fu, De-Li Xia, Meng-Lan Mao, Dan-Lu Shi, Zun-Li Ke. [Intervention effect of Erchen Decoction on methionine and choline deficient diet-induced non-alcoholic steatohepatitis in mice].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2024 Mar; 49(5):1310-1317. doi:
10.19540/j.cnki.cjcmm.20231013.401. [PMID: 38621978] - Tian Lan, Bo Chen, Xianzhe Hu, Jiafan Cao, Shiyun Chen, Xin Ding, Shengwen Li, Yanfang Fu, Huanle Liu, Duosheng Luo, Xianglu Rong, Jiao Guo. Tianhuang formula ameliorates liver fibrosis by inhibiting CCL2-CCR2 axis and MAPK/NF-κB signaling pathway.
Journal of ethnopharmacology.
2024 Mar; 321(?):117516. doi:
10.1016/j.jep.2023.117516. [PMID: 38042390] - Wonseok Kim, Sunhyung Kim, Thomas P Mawhinney, Hari B Krishnan. Elemental sulfur concentration can be used as a rapid, reliable, and cost-effective predictor of sulfur amino acid content of soybean seeds.
Scientific reports.
2024 02; 14(1):3093. doi:
10.1038/s41598-024-53590-3. [PMID: 38326523] - Hao Wu, Tianyu Lou, Mingxia Pan, Zuying Wei, Xiaoqin Yang, Lirong Liu, Menghan Feng, Lixia Shi, Biqiong Qu, Shiyu Cong, Kui Chen, Haolan Yang, Jie Liu, Yueting Li, Zhixin Jia, Hongbin Xiao. Chaihu Guizhi Ganjiang Decoction attenuates nonalcoholic steatohepatitis by enhancing intestinal barrier integrity and ameliorating PPARα mediated lipotoxicity.
Journal of ethnopharmacology.
2024 Feb; ?(?):117841. doi:
10.1016/j.jep.2024.117841. [PMID: 38310988] - Liping Xie, Rui Li, Jinlong Zhang, Heqian Li, Xuejun Gao, Minghui Zhang. Methionine Promotes Milk Synthesis through the BRCC36-BRG1-mTOR Signaling Axis in Mammary Epithelial Cells.
Journal of agricultural and food chemistry.
2024 Jan; 72(4):2135-2144. doi:
10.1021/acs.jafc.3c05370. [PMID: 38240727] - Ai-Cheng Wang, Xiao-Ming Qi, Qing-Fang Li, Yi-Jia Feng, Yuan-Lin Zhang, Hui-Zhi Wei, Jin-Shan Li, Yuan-Biao Qiao, Qing-Shan Li. Methionine redox regulation of actin-interacting proteins primarily governs antioxidative signaling and response to the salvianolic acid B treatment in EA.hy926 cells.
Toxicology and applied pharmacology.
2024 Jan; 483(?):116835. doi:
10.1016/j.taap.2024.116835. [PMID: 38272317] - Ah Young Yang, Kiryeong Kim, Hyun Hee Kwon, Jaechan Leem, Jeong Eun Song. 6-Shogaol Ameliorates Liver Inflammation and Fibrosis in Mice on a Methionine- and Choline-Deficient Diet by Inhibiting Oxidative Stress, Cell Death, and Endoplasmic Reticulum Stress.
Molecules (Basel, Switzerland).
2024 Jan; 29(2):. doi:
10.3390/molecules29020419. [PMID: 38257332] - Huan He, Ziwei Wang, Xueke Peng, Luolong Qing, Yu Zhang, Shaojuan Fu, Juan Xu, Yuanyuan Li, Silong Zhang. Identification of a Sonically Activated Degrader of Methionine Adenosyltransferase 2A by an in Silico Approach Assisted with the Hole-Electron Analysis.
Journal of medicinal chemistry.
2024 Jan; 67(1):543-554. doi:
10.1021/acs.jmedchem.3c01770. [PMID: 38166392] - Chutikun Kanjanaruch, Kerri A Bochantin, Bethania J Dávila Ruiz, Jessica Syring, Yssi Entzie, Layla King, Pawel P Borowicz, Matthew S Crouse, Joel S Caton, Carl R Dahlen, Alison K Ward, Lawrence P Reynolds. One-carbon metabolite supplementation to nutrient-restricted beef heifers affects placental vascularity during early pregnancy.
Journal of animal science.
2024 Jan; 102(?):. doi:
10.1093/jas/skae044. [PMID: 38407272] - Yingying Du, Xiaowen Lin, Xianping Shao, Jianhua Zhao, Hong Xu, Clement R de Cruz, Qiyou Xu. Effects of supplementing coated methionine in a high plant-protein diet on growth, antioxidant capacity, digestive enzymes activity and expression of TOR signaling pathway associated genes in gibel carp, Carassius auratus gibelio.
Frontiers in immunology.
2024; 15(?):1319698. doi:
10.3389/fimmu.2024.1319698. [PMID: 38646543] - Peter Lüth, Henry Sila Nzioki, Claire Sands Baker, David Chandler Sands. A microbial bioherbicide for Striga hermonthica control: production, development, and effectiveness of a seed coating agent.
Pest management science.
2024 Jan; 80(1):149-155. doi:
10.1002/ps.7522. [PMID: 37139834] - Qiang Lyu, Rou-An Chen, Hsiao-Li Chuang, Hsin-Bai Zou, Lihong Liu, Li-Kang Sung, Po-Yu Liu, Hsin-Yi Wu, Hsin-Yuan Chang, Wan-Ju Cheng, Wei-Kai Wu, Ming-Shiang Wu, Cheng-Chih Hsu. Bifidobacterium alleviate metabolic disorders via converting methionine to 5'-methylthioadenosine.
Gut microbes.
2024 Jan; 16(1):2300847. doi:
10.1080/19490976.2023.2300847. [PMID: 38439565] - Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li. Protectin D1 inhibits TLR4 signaling pathway to alleviate non-alcoholic steatohepatitis via upregulating IRAK-M.
Free radical biology & medicine.
2024 Jan; 210(?):42-53. doi:
10.1016/j.freeradbiomed.2023.11.011. [PMID: 37984750] - Razia Liaqat, Shafaq Fatima, Wajeeha Komal, Qandeel Minahal, Aya S Hussain. Dietary supplementation of methionine, lysine, and tryptophan as possible modulators of growth, immune response, and disease resistance in striped catfish (Pangasius hypophthalmus).
PloS one.
2024; 19(4):e0301205. doi:
10.1371/journal.pone.0301205. [PMID: 38625974] - Ildefonso Rodriguez-Ramiro, Andrés Pastor-Fernández, José Luis López-Aceituno, Esther Garcia-Dominguez, Aranzazu Sierra-Ramirez, Angela M Valverde, Bárbara Martinez-Pastor, Alejo Efeyan, Mari Carmen Gomez-Cabrera, José Viña, Pablo J Fernandez-Marcos. Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice.
Free radical biology & medicine.
2024 Jan; 210(?):448-461. doi:
10.1016/j.freeradbiomed.2023.11.019. [PMID: 38036067] - Dong-Keon Lee, Su Ho Jo, Eun Soo Lee, Kyung Bong Ha, Na Won Park, Deok-Hoon Kong, Sang-In Park, Joon Seok Park, Choon Hee Chung. DWN12088, A Prolyl-tRNA Synthetase Inhibitor, Alleviates Hepatic Injury in Nonalcoholic Steatohepatitis.
Diabetes & metabolism journal.
2024 Jan; 48(1):97-111. doi:
10.4093/dmj.2022.0367. [PMID: 38173372] - Samanta Raboni, Serena Faggiano, Stefano Bettati, Andrea Mozzarelli. Methionine gamma lyase: Structure-activity relationships and therapeutic applications.
Biochimica et biophysica acta. Proteins and proteomics.
2023 Dec; 1872(3):140991. doi:
10.1016/j.bbapap.2023.140991. [PMID: 38147934] - Qingying Lan, Chang Zhang, Hong Hua, Xiaosheng Hu. Compositional and functional changes in the salivary microbiota related to oral leukoplakia and oral squamous cell carcinoma: a case control study.
BMC oral health.
2023 12; 23(1):1021. doi:
10.1186/s12903-023-03760-y. [PMID: 38115005] - Václav Šmíd, Karel Dvořák, Kamila Stehnová, Hynek Strnad, Josep Rubert, Jan Stříteský, Barbora Staňková, Milena Stránská, Jana Hajšlová, Radan Brůha, Libor Vítek. The Ameliorating Effects of n-3 Polyunsaturated Fatty Acids on Liver Steatosis Induced by a High-Fat Methionine Choline-Deficient Diet in Mice.
International journal of molecular sciences.
2023 Dec; 24(24):. doi:
10.3390/ijms242417226. [PMID: 38139055] - Xue Wu, Huaixuan Ao, Xiaoyong Wu, Yunfeng Cao. Sulfur-containing amino acids and risk of schizophrenia.
Schizophrenia research.
2023 Dec; 262(?):8-17. doi:
10.1016/j.schres.2023.10.016. [PMID: 37918291] - Mengmeng Sun, Shu Huang, Shaojuan Jiang, Gehong Su, Zhiwei Lu, Chun Wu, Qiaobo Ye, Bin Feng, Yong Zhuo, Xuemei Jiang, Shengyu Xu, De Wu, Danni Liu, Xianyang Song, Chang Song, Xiaorong Yan, Hanbing Rao. The mechanism of nanozyme activity of ZnO-Co3O4-v: Oxygen vacancy dynamic change and bilayer electron transfer pathway for wound healing and virtual reality revealing.
Journal of colloid and interface science.
2023 Nov; 650(Pt B):1786-1800. doi:
10.1016/j.jcis.2023.06.140. [PMID: 37506419] - Xiuyu Wang, Xing Ma, Yue Zeng, Lingbo Xu, Minghao Zhang. Hypermethylation of the CTRP9 promoter region promotes Hcy induced VSMC lipid deposition and foam cell formation via negatively regulating ER stress.
Scientific reports.
2023 11; 13(1):19438. doi:
10.1038/s41598-023-46981-5. [PMID: 37945738] - Dong Yun Kim, Jun Yong Park, Heon Yung Gee. Lactobacillus plantarum ameliorates NASH-related inflammation by upregulating L-arginine production.
Experimental & molecular medicine.
2023 Nov; ?(?):. doi:
10.1038/s12276-023-01102-0. [PMID: 37907736] - Hua-Jun Li, Yuan-Song Wang, Ya-Nan Wang, Ai-Ru Liu, Xiu-Hai Su, Zi-Ang Ma, Li-Xin Wang, Zhong-Yong Zhang, Shu-Quan Lv, Jing Miao, Huan-Tian Cui. Mechanical study of alisol B 23-acetate on methionine and choline deficient diet-induced nonalcoholic steatohepatitis based on untargeted metabolomics.
Biomedical chromatography : BMC.
2023 Oct; ?(?):e5763. doi:
10.1002/bmc.5763. [PMID: 37858975] - Ying Quan, Diwen Shou, Siqi Yang, Jiemin Cheng, Yongqiang Li, Chen Huang, Huiting Chen, Yongjian Zhou. Mdivi1 ameliorates mitochondrial dysfunction in non-alcoholic steatohepatitis by inhibiting JNK/MFF signaling.
Journal of gastroenterology and hepatology.
2023 Oct; ?(?):. doi:
10.1111/jgh.16372. [PMID: 37839851] - Hao Qi, Gang Lin, Siqi Guo, Xudong Guo, Congying Yu, Minghui Zhang, Xuejun Gao. Met stimulates ARID1A degradation and activation of the PI3K-SREBP1 signaling to promote milk fat synthesis in bovine mammary epithelial cells.
Animal biotechnology.
2023 Oct; ?(?):1-11. doi:
10.1080/10495398.2023.2265167. [PMID: 37837279] - Yoon-Kwang Lee, Jung Eun Park, Mikang Lee, Ryan Mifflin, Yang Xu, Robert Novak, Yanqiao Zhang, James P Hardwick. Deletion of hepatic Small Heterodimer Partner ameliorates development of nonalcoholic steatohepatitis in mice.
Journal of lipid research.
2023 Oct; ?(?):100454. doi:
10.1016/j.jlr.2023.100454. [PMID: 37827334] - Jinge Gu, Xiaoming Zhou, Lillian Sutherland, Masato Kato, Klaudia Jaczynska, Josep Rizo, Steven L McKnight. Oxidative regulation of TDP-43 self-association by a β-to-α conformational switch.
Proceedings of the National Academy of Sciences of the United States of America.
2023 10; 120(41):e2311416120. doi:
10.1073/pnas.2311416120. [PMID: 37782781] - Liuchun Feng, Qi Li, Dongqin Zhou, Mingyun Jia, Zhuangzhuang Liu, Zhaoqi Hou, Quanjin Ren, Shengdong Ji, Shifei Sang, Shipeng Lu, Jinping Yu. B. subtilis CNBG-PGPR-1 induces methionine to regulate ethylene pathway and ROS scavenging for improving salt tolerance of tomato.
The Plant journal : for cell and molecular biology.
2023 Oct; ?(?):. doi:
10.1111/tpj.16489. [PMID: 37812678] - Xin Liu, Yi Fang, Chenchen Qian, Jiahao Chen, Wu Luo, Wei Zuo, Jianjun Lin, Longteng Xie, Guang Liang, Lijiang Huang, Yi Wang. CARD9 deficiency aggravated nonalcoholic steatohepatitis in mice through increasing inflammatory response.
Biochimica et biophysica acta. Molecular basis of disease.
2023 Sep; 1870(1):166893. doi:
10.1016/j.bbadis.2023.166893. [PMID: 37751783] - Alyssa Paoletti, Paul B Pencharz, Ronald O Ball, Dehan Kong, Libai Xu, Rajavel Elango, Glenda Courtney-Martin. The Minimum Methionine Requirement for Adults Aged ≥60 Years Is the Same in Males and Females.
Nutrients.
2023 Sep; 15(19):. doi:
10.3390/nu15194112. [PMID: 37836396] - Youngmi Song, Hyekyung Yang, Juhee Kim, Yoonjin Lee, Sung-Ho Kim, In-Gu Do, Cheol-Young Park. Gemigliptin, a DPP4 inhibitor, ameliorates nonalcoholic steatohepatitis through AMP-activated protein kinase-independent and ULK1-mediated autophagy.
Molecular metabolism.
2023 Sep; 78(?):101806. doi:
10.1016/j.molmet.2023.101806. [PMID: 37739179] - Ting Zhai, Junjun Wang, Yong Chen. Honokiol affects the composition of gut microbiota and the metabolism of lipid and bile acid in methionine-choline deficiency diet-induced NASH mice.
Scientific reports.
2023 Sep; 13(1):15203. doi:
10.1038/s41598-023-42358-w. [PMID: 37709801] - Huimin Li, Pengcheng Mo, Jun Zhang, Zhuoer Xie, Xinyu Liu, Han Chen, Leiyun Yang, Muxing Liu, Haifeng Zhang, Ping Wang, Zhengguang Zhang. Methionine biosynthesis enzyme MoMet2 is required for rice blast fungus pathogenicity by promoting virulence gene expression via reducing 5mC modification.
PLoS genetics.
2023 09; 19(9):e1010927. doi:
10.1371/journal.pgen.1010927. [PMID: 37733784] - Moona Rahikainen. Behind the seeds: Genetically engineered methionine-rich Arabidopsis seeds show altered metabolism and DNA methylation.
Plant physiology.
2023 08; 193(1):179-181. doi:
10.1093/plphys/kiad367. [PMID: 37369094] - Junko Asakura, Manabu Nagao, Masakazu Shinohara, Makoto Nishimori, Sachiko Yoshikawa, Takuya Iino, Yutaro Seto, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh. Plasma cystine/methionine ratio is associated with left ventricular diastolic function in patients with heart disease.
Heart and vessels.
2023 Aug; ?(?):. doi:
10.1007/s00380-023-02302-4. [PMID: 37620665] - Yang Ling, Zhang Jinshi, Qian Yilu, Lian Jinjin, Li Mei, Zhang Weilin. Transcriptome profiling reveals ethylene formation in rice seeds by trichloroisocyanuric acid.
Plant cell reports.
2023 Aug; ?(?):. doi:
10.1007/s00299-023-03058-x. [PMID: 37594528] - Abou Yobi, Huda Ansaf, Ruthie Angelovici. A High-Throughput Absolute Quantification of Protein-Bound Sulfur Amino Acids from Model and Crop Plant Seeds.
Current protocols.
2023 Aug; 3(8):e861. doi:
10.1002/cpz1.861. [PMID: 37540769] - Shiyun Pu, Jingyi Zhang, Changyu Ren, Hongjing Zhou, Yan Wang, Yuanli Wu, Shuangyu Yang, Fangyin Cao, Houfeng Zhou. Montelukast prevents mice against carbon tetrachloride- and methionine-choline deficient diet-induced liver fibrosis: Reducing hepatic stellate cell activation and inflammation.
Life sciences.
2023 Jul; 325(?):121772. doi:
10.1016/j.lfs.2023.121772. [PMID: 37178864] - Jennifer Scott, Jorge Amich. The role of methionine synthases in fungal metabolism and virulence.
Essays in biochemistry.
2023 Jul; ?(?):. doi:
10.1042/ebc20230007. [PMID: 37449444] - Hui Zhou, Bin Niu, Xue Wu, Weike Chu, Yibing Zhou, Ze Chen, Yuqiang Mi, Yonggang Liu, Ping Li. iTRAQ-based quantitative proteomics analysis of the effect of ACT001 on non-alcoholic steatohepatitis in mice.
Scientific reports.
2023 07; 13(1):11336. doi:
10.1038/s41598-023-38448-4. [PMID: 37443174] - Zhong-Ce Hu, Yun-Chao Tao, Jun-Chao Pan, Chui-Mu Zheng, Yuan-Shan Wang, Ya-Ping Xue, Zhi-Qiang Liu, Yu-Guo Zheng. Breeding of Saccharomyces cerevisiae with a High-Throughput Screening Strategy for Improvement of S-Adenosyl-L-Methionine Production.
Applied biochemistry and biotechnology.
2023 Jul; ?(?):. doi:
10.1007/s12010-023-04622-7. [PMID: 37418127] - Yongli Han, Lingling Luo, Hongli Li, Lijun Zhang, Yingxuan Yan, Minglv Fang, Jing Yu, Xiaoyan Gao, Ying Liu, Cheng Huang, Shengjie Fan. Nomilin and its analogue obacunone alleviate NASH and hepatic fibrosis in mice via enhancing antioxidant and anti-inflammation capacity.
BioFactors (Oxford, England).
2023 Jul; ?(?):. doi:
10.1002/biof.1987. [PMID: 37401768] - Doosan Shin, Veronica C Perez, Gabriella K Dickinson, Haohao Zhao, Ru Dai, Breanna Tomiczek, Keun Ho Cho, Ning Zhu, Jin Koh, Alexander Grenning, Jeongim Kim. Altered methionine metabolism impacts phenylpropanoid production and plant development in Arabidopsis thaliana.
The Plant journal : for cell and molecular biology.
2023 Jun; ?(?):. doi:
10.1111/tpj.16370. [PMID: 37366635] - Aiswarya Girija, Yael Hacham, Shachar Dvir, Sayantan Panda, Michal Lieberman-Lazarovich, Rachel Amir. Cystathionine γ-synthase expression in seeds alters metabolic and DNA methylation profiles in Arabidopsis.
Plant physiology.
2023 Jun; ?(?):. doi:
10.1093/plphys/kiad330. [PMID: 37300538] - Yutaro Kubota, Qinghong Han, Jose Reynoso, Yusuke Aoki, Noriyuki Masaki, Koya Obara, Kazuyuki Hamada, Michael Bouvet, Takuya Tsunoda, Robert M Hoffman. Old-age-induced obesity reversed by a methionine-deficient diet or oral administration of recombinant methioninase-producing Escherichia coli in C57BL/6 mice.
Aging.
2023 06; 15(11):4642-4648. doi:
10.18632/aging.204783. [PMID: 37301544] - Wei Jia, Xixuan Wu, Ning Liu, Zengrun Xia, Lin Shi. Quantitative fusion omics reveals that refrigeration drives methionine degradation through perturbing 5-methyltetrahydropteroyltriglutamate-homocysteine activity.
Food chemistry.
2023 May; 409(?):135322. doi:
10.1016/j.foodchem.2022.135322. [PMID: 36584532] - Esra Tuğçe Gül, Osman Olgun, Gözde Kılınç, Alpönder Yıldız, Ainhoa Sarmiento-García. Does the addition of choline and/or betaine to diets reduce the methionine requirements of laying quails? Assessment of performance and egg antioxidant capacity.
Poultry science.
2023 May; 102(8):102816. doi:
10.1016/j.psj.2023.102816. [PMID: 37302323] - Pan-Pan Tian, Yu-Lin Zhang, Jing-Ling Huang, Wang-Yan Li, Xiang-Dong Liu. Arsenophonus Interacts with Buchnera to Improve Growth Performance of Aphids under Amino Acid Stress.
Microbiology spectrum.
2023 May; ?(?):e0179223. doi:
10.1128/spectrum.01792-23. [PMID: 37222634] - U Arshad, A Husnain, M B Poindexter, R Zimpel, M C Perdomo, J E P Santos. Effect of source and amount of rumen-protected choline on hepatic metabolism during induction of fatty liver in dairy cows.
Journal of dairy science.
2023 May; ?(?):. doi:
10.3168/jds.2023-23270. [PMID: 37210357] - S B Potts, K M Brady, C M Scholte, K M Moyes, N E Sunny, R A Erdman. Rumen-protected choline and methionine during the periparturient period affect choline metabolites, amino acids, and hepatic expression of genes associated with one-carbon and lipid metabolism.
Journal of dairy science.
2023 May; ?(?):. doi:
10.3168/jds.2022-22334. [PMID: 37173256] - Pallath Muhammed Nuzaiba, Subodh Gupta, Shobha Gupta, Sanjay Balkrishna Jadhao. Synthesis of L-methionine-loaded chitosan nanoparticles for controlled release and their in vitro and in vivo evaluation.
Scientific reports.
2023 May; 13(1):7606. doi:
10.1038/s41598-023-34448-6. [PMID: 37164991] - Elena C Tore, Simone J P M Eussen, Nasser E Bastani, Pieter C Dagnelie, Amany K Elshorbagy, Pol Grootswagers, Viktor Kožich, Thomas Olsen, Helga Refsum, Kjetil Retterstøl, Coen DA Stehouwer, Emma T K Stolt, Kathrine J Vinknes, Marleen M J van Greevenbroek. The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study.
The Journal of nutrition.
2023 May; ?(?):. doi:
10.1016/j.tjnut.2023.05.008. [PMID: 37164267] - Jie Xu, Xin-Ling Wang, Han-Fang Zeng, Zhao-Yu Han. Methionine alleviates heat stress-induced ferroptosis in bovine mammary epithelial cells through the Nrf2 pathway.
Ecotoxicology and environmental safety.
2023 May; 256(?):114889. doi:
10.1016/j.ecoenv.2023.114889. [PMID: 37079940] - Yong Zhuo, Xiangyang Zou, Ya Wang, Xuemei Jiang, Mengmeng Sun, Shengyu Xu, Yan Lin, Lun Hua, Jian Li, Bin Feng, Zhengfeng Fang, Lianqiang Che, De Wu. Standardized ileal digestibility of amino acids in cottonseed meal fed to pregnant and non-pregnant sows.
Journal of animal science.
2023 Apr; ?(?):. doi:
10.1093/jas/skad132. [PMID: 37119089] - Matin Jamei, Ali Asghar Sadeghi, Mohammad Chamani. Dose-responses of zinc as zinc-methionine supplements on antioxidant status, hematological parameters, immune response and the expression of IL-4 and IL-6 genes of ewes in the hot season.
Animal biotechnology.
2023 Apr; ?(?):1-9. doi:
10.1080/10495398.2023.2200428. [PMID: 37078772] - Si Li, Xi Wu, Yue Ma, Hua Zhang, Wen Chen. Prediction and verification of the active ingredients and potential targets of Erhuang Quzhi Granules on non-alcoholic fatty liver disease based on network pharmacology.
Journal of ethnopharmacology.
2023 Apr; ?(?):116435. doi:
10.1016/j.jep.2023.116435. [PMID: 37023836] - Pavan S Upadhyayula, Dominique M Higgins, Angeliki Mela, Matei Banu, Athanassios Dovas, Fereshteh Zandkarimi, Purvi Patel, Aayushi Mahajan, Nelson Humala, Trang T T Nguyen, Kunal R Chaudhary, Lillian Liao, Michael Argenziano, Tejaswi Sudhakar, Colin P Sperring, Benjamin L Shapiro, Eman R Ahmed, Connor Kinslow, Ling F Ye, Markus D Siegelin, Simon Cheng, Rajesh Soni, Jeffrey N Bruce, Brent R Stockwell, Peter Canoll. Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism.
Nature communications.
2023 Mar; 14(1):1187. doi:
10.1038/s41467-023-36630-w. [PMID: 36864031] - Jamras Kanchanapiboon, Arnatchai Maiuthed, Pattarawit Rukthong, Sudaluck Thunyaharn, Sasiwan Tuntoaw, Subhadhcha Poonsatha, Wichai Santimaleeworagun. Metabolomics profiling of culture medium reveals association of methionine and vitamin B metabolisms with virulent phenotypes of clinical bloodstream-isolated Candida albicans.
Research in microbiology.
2023 Mar; 174(3):104009. doi:
10.1016/j.resmic.2022.104009. [PMID: 36403754] - Wei Gao, Linzhang Zhang, Jianjun Wu, Yongbin Xu, Shenglan Qi, Wei Liu, Ping Liu, Songshan Shi, Huijun Wang, Qiaoyan Zhang, Yongli Wang, Shunchun Wang. Extraction, characterization, and anti-nonalcoholic steatohepatitis activity of a (1,3) (1,6)-β-D-glucan from the Polyporus umbellatus (Pers.) Fries.
International journal of biological macromolecules.
2023 Mar; 230(?):123252. doi:
10.1016/j.ijbiomac.2023.123252. [PMID: 36639082] - Xiaoqing Huang, Qiongyun Chen, Yanyun Fan, Renzhi Yang, Guoyu Gong, Changsheng Yan, Yang Song, Bangzhou Zhang, Shengyan Xi, Yuanpeng Huang, Hongzhi Xu. Fructooligosaccharides attenuate non-alcoholic fatty liver disease by remodeling gut microbiota and association with lipid metabolism.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Mar; 159(?):114300. doi:
10.1016/j.biopha.2023.114300. [PMID: 36696803] - Ana Belén Uceda, Juan Frau, Bartolomé Vilanova, Miquel Adrover. On the effect of methionine oxidation on the interplay between α-synuclein and synaptic-like vesicles.
International journal of biological macromolecules.
2023 Feb; 229(?):92-104. doi:
10.1016/j.ijbiomac.2022.12.262. [PMID: 36584779] - Shaobo Wu, Yao Wu, Lan Lin, Changshun Ruan, Fang Li, Rong Chen, Hongxin Du, Xianxiang Zhang, Xiaohe Luo. Osteoprotegerin deficiency aggravates methionine-choline-deficient diet-induced nonalcoholic steatohepatitis in mice.
Scientific reports.
2023 Feb; 13(1):3194. doi:
10.1038/s41598-023-30001-7. [PMID: 36823220] - Chunyu Guo, Qingjun Li, Rihong Chen, Wenhui Fan, Xin Zhang, Yuqian Zhang, Lanping Guo, Xiao Wang, Xinyan Qu, Hongjing Dong. Baicalein alleviates non-alcoholic fatty liver disease in mice by ameliorating intestinal barrier dysfunction.
Food & function.
2023 Feb; 14(4):2138-2148. doi:
10.1039/d2fo03015b. [PMID: 36752061] - Jun-Min Lee, Min-Ho Park, Bu-Soo Park, Min-Kyu Oh. Production of S-methyl-methionine using engineered Saccharomyces cerevisiae sake K6.
Journal of industrial microbiology & biotechnology.
2023 Feb; 50(1):. doi:
10.1093/jimb/kuad026. [PMID: 37653437] - Xiaoxu Yang, Chang Liu, Mengdi Li, Yanmei Li, Zhishan Yan, Guojun Feng, Dajun Liu. Integrated transcriptomics and metabolomics analysis reveals key regulatory network that response to cold stress in common Bean (Phaseolus vulgaris L.).
BMC plant biology.
2023 Feb; 23(1):85. doi:
10.1186/s12870-023-04094-1. [PMID: 36759761] - Thaís Pacheco Santana, Eliane Gasparino, Angélica de Souza Khatlab, Angela Maria Favaro Elias Pereira, Leandro Teixeira Barbosa, Roberta Pereira Miranda Fernandes, Susan J Lamont, Ana Paula Del Vesco. Effects of maternal methionine supplementation on the response of Japanese quail (Coturnix coturnix japonica) chicks to heat stress.
Journal of animal science.
2023 Feb; ?(?):. doi:
10.1093/jas/skad042. [PMID: 36734330] - Haiwen Chen, Jintao Cheng, Yuan Huang, Qiusheng Kong, Zhilong Bie. Comparative analysis of sugar, acid, and volatile compounds in CPPU-treated and honeybee-pollinated melon fruits during different developmental stages.
Food chemistry.
2023 Feb; 401(?):134072. doi:
10.1016/j.foodchem.2022.134072. [PMID: 36108381] - Xiaoping Li, Jinke Geng, Mutian Han. [Adoptive bone marrow cells can reduce the liver injury of metabolic-dysfunction-associated fatty liver disease in mice by differentiating into natural killer T (NKT) cells and increasing their own lipid content].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2023 Feb; 39(2):124-129. doi:
. [PMID: 36872430] - Danfeng Lin, Qiyan Sun, Zhaoyang Liu, Jiaxuan Pan, Jing Zhu, Shangwen Wang, Sining Jia, Minghua Zheng, Xiaokun Li, Fanghua Gong. Gut microbiota and bile acids partially mediate the improvement of fibroblast growth factor 21 on methionine-choline-deficient diet-induced non-alcoholic fatty liver disease mice.
Free radical biology & medicine.
2023 02; 195(?):199-218. doi:
10.1016/j.freeradbiomed.2022.12.087. [PMID: 36586452] - L Jiménez-Munoz, M Torp Nielsen, L Roman, M Corredig. Variation of in vitro digestibility of pea protein powder dispersions from commercially available sources.
Food chemistry.
2023 Feb; 401(?):134178. doi:
10.1016/j.foodchem.2022.134178. [PMID: 36099815] - Tetsuya Hirabayashi, Mai Kawaguchi, Sayaka Harada, Misa Mouri, Rina Takamiya, Yoshimi Miki, Hiroyasu Sato, Yoshitaka Taketomi, Kohei Yokoyama, Tetsuyuki Kobayashi, Suzumi M Tokuoka, Yoshihiro Kita, Emiko Yoda, Shuntaro Hara, Kyohei Mikami, Yasumasa Nishito, Norihito Kikuchi, Rieko Nakata, Mari Kaneko, Hiroshi Kiyonari, Kohji Kasahara, Toshiki Aiba, Kazutaka Ikeda, Tomoyoshi Soga, Makoto Kurano, Yutaka Yatomi, Makoto Murakami. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups.
Cell reports.
2023 Jan; 42(2):111940. doi:
10.1016/j.celrep.2022.111940. [PMID: 36719796] - Yuhui Yang, Manman Lu, Jing Qian, Yuncong Xu, Bowen Li, Guowei Le, Yanli Xie. Dietary Methionine Restriction Promotes Fat Browning and Attenuates Hepatic Lipid Accumulation in High-Choline-Fed Mice Associated with the Improvement of Thyroid Function.
Journal of agricultural and food chemistry.
2023 Jan; 71(3):1447-1463. doi:
10.1021/acs.jafc.2c05535. [PMID: 36632677] - Ariana Julia B Gayban, Lucas A C Souza, Silvana G Cooper, Erick Regalado, Robert Kleemann, Yumei Feng Earley. (Pro)Renin Receptor Antagonism Attenuates High-Fat-Diet-Induced Hepatic Steatosis.
Biomolecules.
2023 01; 13(1):. doi:
10.3390/biom13010142. [PMID: 36671527] - Chloe Quilliam, Luciana G Reis, Yikai Ren, Yongfeng Ai, Lynn P Weber. Effects of a 28-day feeding trial of grain-containing versus pulse-based diets on cardiac function, taurine levels and digestibility in domestic dogs.
PloS one.
2023; 18(5):e0285381. doi:
10.1371/journal.pone.0285381. [PMID: 37228111] - Lisha Zhu, Lin Chen, Chaojie Wu, Wei Shan, Danling Cai, Zengxiang Lin, Wei Wei, Jianye Chen, Wangjin Lu, Jianfei Kuang. Methionine oxidation and reduction of the ethylene signaling component MaEIL9 are involved in banana fruit ripening.
Journal of integrative plant biology.
2023 Jan; 65(1):150-166. doi:
10.1111/jipb.13363. [PMID: 36103229] - Yan Yao, Zhi-Pan Luo, Hai-Wen Li, Shu-Xian Wang, Yin-Cui Wu, Ying Hu, Shuang Hu, Chen-Chen Yang, Jun-Fa Yang, Jian-Peng Wang, Li Peng, Fei Chen, Lin-Xin Pan, Tao Xu. P38γ modulates the lipid metabolism in non-alcoholic fatty liver disease by regulating the JAK-STAT signaling pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 01; 37(1):e22716. doi:
10.1096/fj.202200939rr. [PMID: 36527390] - Jianhua Huang, Lijun Wang, Yanjun Guo, Chuying Chen, Zhihua Song, Xingguo Wang. Effects of amino acids on the formation and distribution of glycerol core aldehydes during deep frying.
Food research international (Ottawa, Ont.).
2023 01; 163(?):112257. doi:
10.1016/j.foodres.2022.112257. [PMID: 36596168] - Mengyao Yan, Shuli Man, Yueru Liang, Long Ma, Lanping Guo, Luqi Huang, Wenyuan Gao. Diosgenin alleviates nonalcoholic steatohepatitis through affecting liver-gut circulation.
Pharmacological research.
2023 01; 187(?):106621. doi:
10.1016/j.phrs.2022.106621. [PMID: 36535571] - Qin Zhang, Hong Zhang, Chun-Mei Yang, Bo Wang, Chen-Yang Li, Qi Li. [Mechanism of active ingredients in Periploca forrestii compound against rheumatoid arthritis based on integrative metabolomics and network pharmacology].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Jan; 48(2):507-516. doi:
10.19540/j.cnki.cjcmm.20220913.702. [PMID: 36725240] - Noriko Suzuki-Kemuriyama, Akari Abe, Sae Nakane, Megumi Yuki, Katsuhiro Miyajima, Dai Nakae. Nonalcoholic steatohepatitis-associated hepatocarcinogenesis in mice fed a modified choline-deficient, methionine-lowered, L-amino acid-defined diet and the role of signal changes.
PloS one.
2023; 18(8):e0287657. doi:
10.1371/journal.pone.0287657. [PMID: 37535625] - Liang Xu, Haoran Li, Ouyang Zhang, Fengming Zhang, Menghui Song, Mengchen Ma, Youjuan Zhao, Rongxiu Ding, Dandan Li, Zhixiong Dong, Shengnan Jin, Weiping Han, Chunming Ding. Melatonin alleviates diet-induced steatohepatitis by targeting multiple cell types in the liver to suppress inflammation and fibrosis.
Journal of molecular endocrinology.
2023 Jan; 70(1):. doi:
10.1530/jme-22-0075. [PMID: 36356262] - Qingcai Zhen, Qijian Liang, Hongchun Wang, Yan Zheng, Zhongting Lu, Chunyong Bian, Xiulan Zhao, Xin Guo. Theabrownin ameliorates liver inflammation, oxidative stress, and fibrosis in MCD diet-fed C57BL/6J mice.
Frontiers in endocrinology.
2023; 14(?):1118925. doi:
10.3389/fendo.2023.1118925. [PMID: 36742397] - Marissa McGilvrey, Bethany Fortier, Benjamin Tero, Diana Cooke, Emily Cooper, Jeffrey Walker, Robert Koza, Gene Ables, Lucy Liaw. Effects of dietary methionine restriction on age-related changes in perivascular and beiging adipose tissues in the mouse.
Obesity (Silver Spring, Md.).
2023 01; 31(1):159-170. doi:
10.1002/oby.23583. [PMID: 36513498] - Nouf Aljobaily, Kelsey Krutsinger, Michael J Viereckl, Raznin Joly, Bridger Menlove, Brexton Cone, Ailaina Suppes, Yuyan Han. Low-Dose Administration of Cannabigerol Attenuates Inflammation and Fibrosis Associated with Methionine/Choline Deficient Diet-Induced NASH Model via Modulation of Cannabinoid Receptor.
Nutrients.
2022 Dec; 15(1):. doi:
10.3390/nu15010178. [PMID: 36615835]
