Proazulene (BioDeep_00000227700)
Main id: BioDeep_00000007418
human metabolite PANOMIX_OTCML-2023 natural product
代谢物信息卡片
化学式: C17H22O5 (306.1467)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)O[C@H]1CC(C)=C2C=C[C@@](C)(O)[C@@H]2[C@H]2OC(=O)[C@@H](C)[C@H]12
InChI: InChI=1S/C17H22O5/c1-8-7-12(21-10(3)18)13-9(2)16(19)22-15(13)14-11(8)5-6-17(14,4)20/h5-6,9,12-15,20H,7H2,1-4H3/t9-,12-,13+,14-,15-,17+/m0/s1
描述信息
Proazulene, also known as matricine, is a member of the class of compounds known as gamma butyrolactones. Gamma butyrolactones are compounds containing a gamma butyrolactone moiety, which consists of an aliphatic five-member ring with four carbon atoms, one oxygen atom, and bears a ketone group on the carbon adjacent to the oxygen atom. Thus, proazulene is considered to be an isoprenoid lipid molecule. Proazulene is practically insoluble (in water) and a very weakly acidic compound (based on its pKa). Proazulene can be found in anise, which makes proazulene a potential biomarker for the consumption of this food product. Chamazulene, a blue-violet derivative of azulene, found in a variety of plants including in chamomile (Matricaria chamomilla), wormwood (Artemisia absinthium) and yarrow (Achillea millefolium) is biosynthesized from matricin .
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:6699
- KEGG: C09499
- PubChem: 92265
- HMDB: HMDB0302864
- ChEMBL: CHEMBL497441
- KNApSAcK: C00003321
- foodb: FDB006586
- chemspider: 83299
- CAS: 29041-35-8
- PubChem: 11690
- LipidMAPS: LMPR0103410003
- 3DMET: B03024
- NIKKAJI: J286.506H
- KNApSAcK: 6699
- LOTUS: LTS0168849
- LOTUS: LTS0044376
- wikidata: Q105263780
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
44 个相关的物种来源信息
- 13328 - Achillea: LTS0168849
- 282730 - Achillea collina:
- 282730 - Achillea collina: 10.1016/J.PHYTOCHEM.2006.01.033
- 282730 - Achillea collina: 10.1016/J.PHYTOCHEM.2007.04.013
- 282730 - Achillea collina: LTS0168849
- 4219 - Artemisia: LTS0168849
- 86306 - Artemisia abrotanum: 10.1016/0031-9422(79)80167-3
- 86306 - Artemisia abrotanum: LTS0168849
- 72332 - Artemisia absinthium: 10.1016/0031-9422(79)80167-3
- 72332 - Artemisia absinthium: LTS0168849
- 35608 - Artemisia annua: 10.1016/0031-9422(79)80167-3
- 35608 - Artemisia annua: LTS0168849
- 72386 - Artemisia arborescens: 10.1016/0031-9422(82)85255-2
- 72386 - Artemisia arborescens: LTS0168849
- 72337 - Artemisia campestris: 10.1016/0031-9422(79)80167-3
- 72337 - Artemisia campestris: LTS0168849
- 223866 - Artemisia genipi: 10.1016/0031-9422(79)80167-3
- 223866 - Artemisia genipi: LTS0168849
- 72353 - Artemisia splendens: 10.1016/0031-9422(79)80167-3
- 72355 - Artemisia umbelliformis: 10.1016/0031-9422(79)80167-3
- 72355 - Artemisia umbelliformis: LTS0168849
- 669144 - Artemisia vallesiaca: 10.1016/0031-9422(79)80167-3
- 669144 - Artemisia vallesiaca: LTS0168849
- 4220 - Artemisia vulgaris: 10.1016/0031-9422(79)80167-3
- 4220 - Artemisia vulgaris: LTS0168849
- 4210 - Asteraceae: LTS0168849
- 2759 - Eukaryota: LTS0168849
- 9606 - Homo sapiens: -
- 3398 - Magnoliopsida: LTS0168849
- 56016 - Matricaria: LTS0168849
- 98504 - Matricaria chamomilla:
- 98504 - Matricaria chamomilla: 10.1007/978-94-007-1088-7
- 98504 - Matricaria chamomilla: 10.1016/S0731-7085(99)00152-1
- 98504 - Matricaria chamomilla: 10.1021/JF00037A027
- 98504 - Matricaria chamomilla: 10.1055/S-2006-962089
- 98504 - Matricaria chamomilla: 10.1080/10412905.2000.9712049
- 98504 - Matricaria chamomilla: 10.1135/CCCC19591554
- 98504 - Matricaria chamomilla: 10.1201/B14723-2
- 98504 - Matricaria chamomilla: 10.1520/STP25474S
- 98504 - Matricaria chamomilla: LTS0168849
- 99101 - Seriphidium: LTS0168849
- 35493 - Streptophyta: LTS0168849
- 58023 - Tracheophyta: LTS0168849
- 33090 - Viridiplantae: LTS0168849
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kaifeng Fang, Li Wang, LuJia Chen, Tao Liu, Zhi Fang. Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis, Inhibition of Cell Migration, Invasion Suppression, and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway.
Medical science monitor : international medical journal of experimental and clinical research.
2019 04; 25(?):2943-2949. doi:
10.12659/msm.914244. [PMID: 31005960] - Mehdi Sharifi-Rad, Jolanta Nazaruk, Letizia Polito, Maria Flaviana Bezerra Morais-Braga, Janaína Esmeraldo Rocha, Henrique Douglas Melo Coutinho, Bahare Salehi, Giulia Tabanelli, Chiara Montanari, María Del Mar Contreras, Zubaida Yousaf, William N Setzer, Deepa R Verma, Miquel Martorell, Antoni Sureda, Javad Sharifi-Rad. Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications.
Microbiological research.
2018 Oct; 215(?):76-88. doi:
10.1016/j.micres.2018.06.010. [PMID: 30172312] - Frances Watkins, Barbara Pendry, Olivia Corcoran, Alberto Sanchez-Medina. Anglo-Saxon pharmacopoeia revisited: a potential treasure in drug discovery.
Drug discovery today.
2011 Dec; 16(23-24):1069-75. doi:
10.1016/j.drudis.2011.07.002. [PMID: 21782968] - Cheryl Lans, Nancy Turner, Tonya Khan, Gerhard Brauer, Willi Boepple. Ethnoveterinary medicines used for ruminants in British Columbia, Canada.
Journal of ethnobiology and ethnomedicine.
2007 Feb; 3(?):11. doi:
10.1186/1746-4269-3-11. [PMID: 17324258] - Mai Ramadan, Susanne Goeters, Bernhard Watzer, Eva Krause, Klaus Lohmann, Rudolf Bauer, Bernd Hempel, Peter Imming. Chamazulene carboxylic acid and matricin: a natural profen and its natural prodrug, identified through similarity to synthetic drug substances.
Journal of natural products.
2006 Jul; 69(7):1041-5. doi:
10.1021/np0601556. [PMID: 16872141] - C S Kaiser, H Römpp, P C Schmidt. Supercritical carbon dioxide extraction of chamomile flowers: extraction efficiency, stability, and in-line inclusion of chamomile-carbon dioxide extract in beta-cyclodextrin.
Phytochemical analysis : PCA.
2004 Jul; 15(4):249-56. doi:
10.1002/pca.775. [PMID: 15311845] - S Goeters, P Imming, G Pawlitzki, B Hempel. On the absolute configuration of matricin.
Planta medica.
2001 Apr; 67(3):292-4. doi:
10.1055/s-2001-11998. [PMID: 11345709]
