AICAR (BioDeep_00000002270)

 

Secondary id: BioDeep_00000005644, BioDeep_00000399949, BioDeep_00000415794, BioDeep_00000871834

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019


代谢物信息卡片


{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid

化学式: C9H15N4O8P (338.0627)
中文名称: 5-氨基-4-甲酰胺咪唑核糖核苷酸, 5-氨基咪唑-4-甲酰胺-1-Β-D-呋喃核糖苷5-一磷酸盐
谱图信息: 最多检出来源 Homo sapiens(blood) 14.12%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc(c2N)C(=O)O)O1)O)O)OP(=O)(O)O
InChI: InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)/t3-,5-,6-,9-/m1/s1

描述信息

Aicar, also known as 5-phosphoribosyl-5-amino-4-imidazolecarboxamide or 5-aminoimidazole-4-carboxamide ribotide, is a member of the class of compounds known as 1-ribosyl-imidazolecarboxamides. 1-ribosyl-imidazolecarboxamides are organic compounds containing the imidazole ring linked to a ribose ring through a 1-2 bond. Aicar is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Aicar can be found in a number of food items such as safflower, greenthread tea, common pea, and wild leek, which makes aicar a potential biomarker for the consumption of these food products. Aicar can be found primarily in saliva, as well as in human skeletal muscle tissue. Aicar exists in all living species, ranging from bacteria to humans. In humans, aicar is involved in few metabolic pathways, which include azathioprine action pathway, mercaptopurine action pathway, purine metabolism, and thioguanine action pathway. Aicar is also involved in several metabolic disorders, some of which include mitochondrial DNA depletion syndrome, purine nucleoside phosphorylase deficiency, xanthinuria type II, and gout or kelley-seegmiller syndrome.
AICAR also known as ZMP is an analog of AMP that is capable of stimulating AMP-dependent protein kinase activity(AMPK). AICAR is an intermediate in the generation of inosine monophosphate. AICAR is being clinically used to treat and protect against cardiac ischemic injury. AICAR can enter cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia. AICAR increases glucose uptake by inducing translocation of GLUT4 and/or by activating the p38 MAPK pathway.
Acquisition and generation of the data is financially supported in part by CREST/JST.
COVID info from COVID-19 Disease Map
D007004 - Hypoglycemic Agents
Corona-virus
KEIO_ID A133
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

61 个代谢物同义名

{[(2R,3S,4R,5R)-5-(5-amino-4-carbamoyl-1H-imidazol-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}phosphonic acid; (2R,3S,4R,5R)-5-(4-Carbam0yl-5-aminoimidazol-1-yl)-3,4-dihydroxyoxolan-2-yljmethyl dihydrogen phosphate; AICAR (5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5-monophosphate); AICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5’-monophosphate); AICAR (5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5-monophosphate); 5-Amino-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazole-4-carboxamide; 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5-monophosphate; 5-Amino-1-(5-O-phosphono-β-D-ribofuranosyl)-1H-imidazole-4-carboxamide; 5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5-monophosphate; N1-(β-D-5;-Phosphoribofuranosyl)-5-aminoimidazole-4-carboxamide; 5-Amino-1-beta-D-ribofuranosylimidazole-4-carboxamide monophosphate; 5-Aminoimidazole-4-carboxamide-1-β-D-ribofuranosyl 5’-monophosphate; 5-Amino-1beta-D-ribofuranosylimidazole-4-carboxamide 5-phosphate; 5-Amino-1β-D-ribofuranosylimidazole-4-carboxamide 5’-phosphate; 5-Amino-4-imidazolecarboxamide ribonucleoside 5’-monophosphate; 5-Aminoimidazole-4-carboxamide-1-ribofuranosyl 5-monophosphate; 5-Amino-4-imidazolecarboxamide ribofuranoside 5-monophosphate; 5-Amino-1β-D-ribofuranosylimidazole-4-carboxamide 5-phosphate; 5-Amino-4-imidazolecarboxamide ribonucleoside 5-monophosphate; 5-Amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide; 1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxamide (AICAR); 5-Amino-1-(5’-phosphofuranoribosyl)-4-imidazolecarboxamide; 5-Amino-1-(5-phosphofuranoribosyl)-4-imidazolecarboxamide; 5-Amino-4-imidazolecarboxamide riboside 5’-monophosphate; 5-Amino-1-(5-phospho-b-D-ribosyl)imidazole-4-carboxamide; 5-Amino-1-(5-phospho-β-D-ribosyl)imidazole-4-carboxamide; 5-Phospho-beta-D-ribosyl-5-amino-4-imidazolecarboxamide; 5-Amino-4-imidazolecarboxamide riboside 5-monophosphate; 5-amino-1-(5-phospho-D-Ribosyl)imidazole-4-carboxamide; 5’-Phospho-β-D-ribosyl-5-amino-4-imidazolecarboxamide; 5-Phospho-β-D-ribosyl-5-amino-4-imidazolecarboxamide; 1-(5-Phosphoribosyl)-5-amino-4-imidazolecarboxamide; 5-Phospho-ribosyl-5-amino-4-imidazole carboxamide; 5’-Phosphoribosyl-5-amino-4-imidazolecarboxamide; 5-Phosphoribosyl-5-amino-4-imidazole carboxamide; 5-Phosphoribosyl-5-amino-4-imidazolecarboxamide; AICA Ribonucleotide, (D-ribofuranosyl)-isomer; 5-Amino-4-imidazolecarboxamide ribonucleotide; 5-Aminoimidazole-4-carboxamide ribonucleotide; 5-Phosphoribosyl-4-carbamoyl-5-aminoimidazole; 5-p-Ribosyl-5-amino-4-imidazole carboxamide; Aminoimidazole carboxamide ribonucleotide; Aminoimidazolecarboxamide ribonucleotide; 5-Amino-4-imidazolecarboxamide ribotide; 5-Aminoimidazole-4-carboxamide ribotide; 4-Carboxy-5-aminoimidazole ribotide; Acadesine 5-monophosphoric acid; AICAriboside 5-monophosphate; Acadesine 5’-monophosphate; Acadesine 5-monophosphate; AICA-Ribonucleotide; AICAR monophosphate; Aica ribonucleotide; AICA Ribotide; Z-Nucleotide; AICAR; CAIR; ZMP; AICAR; 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide; 5-Aminoimidazole-4-carboxamide-1-酓-ribofuranosyl 5'-monophosphate



数据库引用编号

41 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

256 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(6)

WikiPathways(1)

Plant Reactome(172)

INOH(4)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(60)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ADA, BCL2, CASP3, DHFR, EIF4EBP1, MBD3, MTOR, NT5C2, PRKAA2, RPS6
Peripheral membrane protein 2 ADA, MTOR
Endoplasmic reticulum membrane 2 BCL2, MTOR
Nucleus 10 ADK, ARID1A, BCL2, CASP3, EIF4EBP1, MBD3, MTOR, PRKAA2, RPS6, SMARCA2
cytosol 13 ADA, ADK, ATIC, BCL2, CASP3, DHFR, EIF4EBP1, GART, MTOR, NT5C2, PRKAA2, RPS6, SLC2A4
dendrite 3 MTOR, PRKAA2, RPS6
phagocytic vesicle 1 MTOR
trans-Golgi network 1 SLC2A4
nucleoplasm 8 ADK, ARID1A, CASP3, MBD3, MTOR, PRKAA2, RPS6, SMARCA2
Cell membrane 2 ADA, SLC2A4
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 1 SLC2A4
Golgi apparatus membrane 1 MTOR
cell junction 1 ADA
cell surface 1 ADA
glutamatergic synapse 1 CASP3
Golgi apparatus 1 PRKAA2
Golgi membrane 2 INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, PRKAA2
sarcolemma 1 SLC2A4
Cytoplasm, cytosol 2 ATIC, NT5C2
Lysosome 2 ADA, MTOR
Presynapse 1 SLC2A4
plasma membrane 5 ADA, ADK, ATIC, GCG, SLC2A4
Membrane 7 ADA, ATIC, BCL2, MTOR, PRKAA2, RPS6, SLC2A4
axon 1 PRKAA2
extracellular exosome 3 ATIC, GART, SLC2A4
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 BCL2, RPS6
extracellular space 3 GCG, INS, RBP3
perinuclear region of cytoplasm 2 RPS6, SLC2A4
mitochondrion 2 BCL2, DHFR
protein-containing complex 2 BCL2, MBD3
intracellular membrane-bounded organelle 1 SMARCA2
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 2 GCG, INS
extracellular region 3 GCG, INS, RBP3
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ADA, SLC2A4
Extracellular vesicle 1 RBP3
multivesicular body 1 SLC2A4
T-tubule 1 SLC2A4
nucleolus 1 RPS6
clathrin-coated pit 1 SLC2A4
Cytoplasm, perinuclear region 1 SLC2A4
heterochromatin 1 MBD3
Membrane raft 1 SLC2A4
pore complex 1 BCL2
sarcoplasmic reticulum 1 SLC2A4
Nucleus, PML body 1 MTOR
PML body 1 MTOR
nuclear speck 1 PRKAA2
chromatin 3 ARID1A, MBD3, SMARCA2
Chromosome 2 MBD3, SMARCA2
cytoplasmic ribonucleoprotein granule 1 RPS6
Nucleus, nucleolus 1 RPS6
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, SLC2A4
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 SLC2A4
cytoplasmic stress granule 1 PRKAA2
cell body 1 RPS6
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 SMARCA2
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GCG, INS
transport vesicle 1 INS
small-subunit processome 1 RPS6
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
bBAF complex 2 ARID1A, SMARCA2
brahma complex 2 ARID1A, SMARCA2
nBAF complex 2 ARID1A, SMARCA2
npBAF complex 2 ARID1A, SMARCA2
SWI/SNF complex 2 ARID1A, SMARCA2
NuRD complex 1 MBD3
[Isoform 2]: Cytoplasm 1 ADK
vesicle membrane 1 SLC2A4
ribonucleoprotein complex 1 RPS6
[Isoform 1]: Nucleus 1 ADK
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
cytosolic ribosome 1 RPS6
GBAF complex 1 SMARCA2
RSC-type complex 1 SMARCA2
ribosome 1 RPS6
[Glucagon-like peptide 1]: Secreted 1 GCG
cytosolic small ribosomal subunit 1 RPS6
BAD-BCL-2 complex 1 BCL2
cone matrix sheath 1 RBP3
insulin-responsive compartment 1 SLC2A4
small ribosomal subunit 1 RPS6


文献列表

  • Cunxiang Bo, Fang Liu, Zewen Zhang, Zhongjun Du, Haidi Xiu, Zhenling Zhang, Ming Li, Caiqing Zhang, Qiang Jia. Simvastatin attenuates silica-induced pulmonary inflammation and fibrosis in rats via the AMPK-NOX pathway. BMC pulmonary medicine. 2024 May; 24(1):224. doi: 10.1186/s12890-024-03014-9. [PMID: 38720270]
  • Ye-Rang Yun, Ji-Eun Lee. Kimchi attenuates endoplasmic reticulum stress-induced hepatic steatosis in HepG2 cells and C57BL/6N mice. Nutrition research (New York, N.Y.). 2024 Apr; 124(?):43-54. doi: 10.1016/j.nutres.2024.01.013. [PMID: 38367426]
  • Ajay Krishnan U, Periyasamy Viswanathan, Anuradha Carani Venkataraman. AMPK activation by AICAR reduces diet induced fatty liver in C57BL/6 mice. Tissue & cell. 2023 Mar; 82(?):102054. doi: 10.1016/j.tice.2023.102054. [PMID: 36913846]
  • Doaa Hussein Zineldeen, Nahid Mohamed Tahoon, Naglaa Ibrahim Sarhan. AICAR Ameliorates Non-Alcoholic Fatty Liver Disease via Modulation of the HGF/NF-κB/SNARK Signaling Pathway and Restores Mitochondrial and Endoplasmic Reticular Impairments in High-Fat Diet-Fed Rats. International journal of molecular sciences. 2023 Feb; 24(4):. doi: 10.3390/ijms24043367. [PMID: 36834782]
  • Xiaoguang Chen, Sang-Hoon Kim, Sangkee Rhee, Claus-Peter Witte. A plastid nucleoside kinase is involved in inosine salvage and control of purine nucleotide biosynthesis. The Plant cell. 2023 Jan; 35(1):510-528. doi: 10.1093/plcell/koac320. [PMID: 36342213]
  • Mikhail V Samsonov, Nikita V Podkuychenko, Asker Y Khapchaev, Eugene E Efremov, Elena V Yanushevskaya, Tatiana N Vlasik, Vadim Z Lankin, Iurii S Stafeev, Maxim V Skulachev, Marina V Shestakova, Alexander V Vorotnikov, Vladimir P Shirinsky. AICAR Protects Vascular Endothelial Cells from Oxidative Injury Induced by the Long-Term Palmitate Excess. International journal of molecular sciences. 2021 Dec; 23(1):. doi: 10.3390/ijms23010211. [PMID: 35008640]
  • Israr Ahmad, Adam Molyvdas, Ming-Yuan Jian, Ting Zhou, Amie M Traylor, Huachun Cui, Gang Liu, Weifeng Song, Anupam Agarwal, Tamas Jilling, Saurabh Aggarwal, Sadis Matalon. AICAR decreases acute lung injury by phosphorylating AMPK and upregulating heme oxygenase-1. The European respiratory journal. 2021 12; 58(6):. doi: 10.1183/13993003.03694-2020. [PMID: 34049949]
  • Yong-Kyu Kim, Hye Kyoung Hong, Hyo Soon Yoo, Sung Pyo Park, Kyu Hyung Park. AICAR upregulates ABCA1/ABCG1 expression in the retinal pigment epithelium and reduces Bruch's membrane lipid deposit in ApoE deficient mice. Experimental eye research. 2021 12; 213(?):108854. doi: 10.1016/j.exer.2021.108854. [PMID: 34808137]
  • B Vandanmagsar, Y Yu, C Simmler, T N Dang, P Kuhn, A Poulev, D M Ribnicky, G F Pauli, Z E Floyd. Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Nov; 143(?):112188. doi: 10.1016/j.biopha.2021.112188. [PMID: 34563947]
  • Yuning Pang, Xiang Xu, Xiaojun Xiang, Yongnan Li, Zengqi Zhao, Jiamin Li, Shengnan Gao, Qiangde Liu, Kangsen Mai, Qinghui Ai. High Fat Activates O-GlcNAcylation and Affects AMPK/ACC Pathway to Regulate Lipid Metabolism. Nutrients. 2021 May; 13(6):. doi: 10.3390/nu13061740. [PMID: 34063748]
  • Sitai Liang, Bijaya K Nayak, Kristine S Vogel, Samy L Habib. TP63 Is Significantly Upregulated in Diabetic Kidney. International journal of molecular sciences. 2021 Apr; 22(8):. doi: 10.3390/ijms22084070. [PMID: 33920782]
  • Wang Zhang, Jing-Ya Li, Xiao-Chen Wei, Qian Wang, Ji-Yang Yang, Huan Hou, Zi-Wei Du, Xin-An Wu. Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Mar; 149(?):112029. doi: 10.1016/j.fct.2021.112029. [PMID: 33508418]
  • Shokoufeh Hashempour, Nahid Shahabadi, Aishat Adewoye, Brennen Murphy, Camaray Rouse, Brian A Salvatore, Christopher Stratton, Elahe Mahdavian. Binding Studies of AICAR and Human Serum Albumin by Spectroscopic, Theoretical, and Computational Methodologies. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225410. [PMID: 33228044]
  • Jiwon Park, Yunkyoung Lee, Eun-Hye Jung, Sang-Min Kim, Hyeongjin Cho, Inn-Oc Han. Glucosamine regulates hepatic lipid accumulation by sensing glucose levels or feeding states of normal and excess. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2020 10; 1865(10):158764. doi: 10.1016/j.bbalip.2020.158764. [PMID: 32663610]
  • José M López, Esther L Outtrim, Rong Fu, Diane J Sutcliffe, Rosa J Torres, H A Jinnah. Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease. Proceedings of the National Academy of Sciences of the United States of America. 2020 06; 117(22):12071-12079. doi: 10.1073/pnas.2003475117. [PMID: 32430324]
  • Jonathan Kopel, Kei Higuchi, Bojana Ristic, Toshihiro Sato, Sabarish Ramachandran, Vadivel Ganapathy. The Hepatic Plasma Membrane Citrate Transporter NaCT (SLC13A5) as a Molecular Target for Metformin. Scientific reports. 2020 05; 10(1):8536. doi: 10.1038/s41598-020-65621-w. [PMID: 32444674]
  • Wan-Long Tsai, Chien-Ning Hsu, You-Lin Tain. Whether AICAR in Pregnancy or Lactation Prevents Hypertension Programmed by High Saturated Fat Diet: A Pilot Study. Nutrients. 2020 Feb; 12(2):. doi: 10.3390/nu12020448. [PMID: 32053935]
  • Luping Yang, Yijing Jiang, Lihong Shi, Dongling Zhong, Yuxi Li, Juan Li, Rongjiang Jin. AMPK: Potential Therapeutic Target for Alzheimer's Disease. Current protein & peptide science. 2020; 21(1):66-77. doi: 10.2174/1389203720666190819142746. [PMID: 31424367]
  • J-M Li, W Lu, J Ye, Y Han, H Chen, L-S Wang. Association between expression of AMPK pathway and adiponectin, leptin, and vascular endothelial function in rats with coronary heart disease. European review for medical and pharmacological sciences. 2020 01; 24(2):905-914. doi: 10.26355/eurrev_202001_20075. [PMID: 32016997]
  • Maya W Haaker, Hedwig S Kruitwagen, Arie B Vaandrager, Martin Houweling, Louis C Penning, Martijn R Molenaar, Monique E van Wolferen, Loes A Oosterhoff, Bart Spee, J Bernd Helms. Identification of potential drugs for treatment of hepatic lipidosis in cats using an in vitro feline liver organoid system. Journal of veterinary internal medicine. 2020 Jan; 34(1):132-138. doi: 10.1111/jvim.15670. [PMID: 31830357]
  • Ran Hee Choi, Abigail McConahay, Mackenzie B Johnson, Ha-Won Jeong, Ho-Jin Koh. Adipose tissue-specific knockout of AMPKα1/α2 results in normal AICAR tolerance and glucose metabolism. Biochemical and biophysical research communications. 2019 11; 519(3):633-638. doi: 10.1016/j.bbrc.2019.09.049. [PMID: 31540695]
  • Mamoru Tanida, Yusaku Iwasaki, Naoki Yamamoto. Central Injection of Leptin Increases Sympathetic Nerve Outflows to the Stomach and Spleen in Anesthetized Rats. In vivo (Athens, Greece). 2019 Nov; 33(6):1827-1832. doi: 10.21873/invivo.11675. [PMID: 31662509]
  • Christelle Viglino, Bernard Foglia, Christophe Montessuit. Chronic AICAR treatment prevents metabolic changes in cardiomyocytes exposed to free fatty acids. Pflugers Archiv : European journal of physiology. 2019 09; 471(9):1219-1234. doi: 10.1007/s00424-019-02285-0. [PMID: 31152240]
  • Sreenath Nair, Anne M Strohecker, Avinash K Persaud, Bhawana Bissa, Shanmugam Muruganandan, Craig McElroy, Rakesh Pathak, Michelle Williams, Radhika Raj, Amal Kaddoumi, Alex Sparreboom, Aaron M Beedle, Rajgopal Govindarajan. Adult stem cell deficits drive Slc29a3 disorders in mice. Nature communications. 2019 07; 10(1):2943. doi: 10.1038/s41467-019-10925-3. [PMID: 31270333]
  • Tim Sobolevsky, Brian Ahrens. Urinary concentrations of AICAR and mannitol in athlete population. Drug testing and analysis. 2019 Mar; 11(3):530-535. doi: 10.1002/dta.2557. [PMID: 30548818]
  • Bodokhsuren Tsogbadrakh, Hyunjin Ryu, Kyung Don Ju, Jinho Lee, Sohyun Yun, Kyung-Sang Yu, Hyo Jin Kim, Curie Ahn, Kook-Hwan Oh. AICAR, an AMPK activator, protects against cisplatin-induced acute kidney injury through the JAK/STAT/SOCS pathway. Biochemical and biophysical research communications. 2019 02; 509(3):680-686. doi: 10.1016/j.bbrc.2018.12.159. [PMID: 30616891]
  • Péter Monostori, Glynis Klinke, Jana Hauke, Sylvia Richter, Jörgen Bierau, Sven F Garbade, Georg F Hoffmann, Claus-Dieter Langhans, Dorothea Haas, Jürgen G Okun. Extended diagnosis of purine and pyrimidine disorders from urine: LC MS/MS assay development and clinical validation. PloS one. 2019; 14(2):e0212458. doi: 10.1371/journal.pone.0212458. [PMID: 30817767]
  • Zhifa Wang, Yukun Cao, Qiang Yin, Yuehu Han, Yunya Wang, Guocheng Sun, Hailong Zhu, Ming Xu, Chunhu Gu. Activation of AMPK alleviates cardiopulmonary bypass-induced cardiac injury via ameliorating acute cardiac glucose metabolic disorder. Cardiovascular therapeutics. 2018 Dec; 36(6):e12482. doi: 10.1111/1755-5922.12482. [PMID: 30632675]
  • Jianlong Gao, Rui Xiong, Dan Xiong, Wenxing Zhao, Sheng Zhang, Tao Yin, Xinhua Zhang, Guozhen Jiang, Zhengyu Yin. The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN). Medical science monitor : international medical journal of experimental and clinical research. 2018 Nov; 24(?):8533-8543. doi: 10.12659/msm.910544. [PMID: 30474622]
  • Carolina Nylén, Wataru Aoi, Ahmed M Abdelmoez, David G Lassiter, Leonidas S Lundell, Harriet Wallberg-Henriksson, Erik Näslund, Nicolas J Pillon, Anna Krook. IL6 and LIF mRNA expression in skeletal muscle is regulated by AMPK and the transcription factors NFYC, ZBTB14, and SP1. American journal of physiology. Endocrinology and metabolism. 2018 11; 315(5):E995-E1004. doi: 10.1152/ajpendo.00398.2017. [PMID: 29688769]
  • Sitai Liang, Edward A Medina, Boajie Li, Samy L Habib. Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer. Molecular oncology. 2018 11; 12(11):1917-1934. doi: 10.1002/1878-0261.12370. [PMID: 30107094]
  • Yu Inata, Giovanna Piraino, Paul W Hake, Michael O'Connor, Patrick Lahni, Vivian Wolfe, Christine Schulte, Victoria Moore, Jeanne M James, Basilia Zingarelli. Age-dependent cardiac function during experimental sepsis: effect of pharmacological activation of AMP-activated protein kinase by AICAR. American journal of physiology. Heart and circulatory physiology. 2018 10; 315(4):H826-H837. doi: 10.1152/ajpheart.00052.2018. [PMID: 29979626]
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