1H-Imidazole-4-carboxamide, 5-amino-1-(5-O-phosphono-beta-D-ribofuranosyl)- (BioDeep_00000871834)

Main id: BioDeep_00000002270

 

human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


5-amino-1-{3,4-dihydroxy-5-[(phosphonooxy)methyl]oxolan-2-yl}-1H-imidazole-4-carboximidic acid

化学式: C9H15N4O8P (338.0627)
中文名称: 5-氨基咪唑-4-甲酰胺-1-Β-D-呋喃核糖苷5-一磷酸盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC(=C(N1C2C(C(C(O2)COP(=O)(O)O)O)O)N)C(=O)N
InChI: InChI=1S/C9H15N4O8P/c10-7-4(8(11)16)12-2-13(7)9-6(15)5(14)3(21-9)1-20-22(17,18)19/h2-3,5-6,9,14-15H,1,10H2,(H2,11,16)(H2,17,18,19)



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

26 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Marta Fernández-Galilea, Patricia Pérez-Matute, Pedro L Prieto-Hontoria, J Alfredo Martinez, Maria J Moreno-Aliaga. Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes. Journal of lipid research. 2012 Nov; 53(11):2296-306. doi: 10.1194/jlr.m027086. [PMID: 22941773]
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  • Edgar Sepúlveda-García, Mario Rocha-Sosa. The Arabidopsis F-box protein AtFBS1 interacts with 14-3-3 proteins. Plant science : an international journal of experimental plant biology. 2012 Oct; 195(?):36-47. doi: 10.1016/j.plantsci.2012.06.009. [PMID: 22920997]
  • Christina A Shugrue, Martine Alexandre, Alexander Diaz de Villalvilla, Thomas R Kolodecik, Lawrence H Young, Fred S Gorelick, Edwin C Thrower. Cerulein hyperstimulation decreases AMP-activated protein kinase levels at the site of maximal zymogen activation. American journal of physiology. Gastrointestinal and liver physiology. 2012 Sep; 303(6):G723-32. doi: 10.1152/ajpgi.00082.2012. [PMID: 22821946]
  • Eun Jeong Lee, Minseok Kang, Yeong Shik Kim. Platycodin D inhibits lipogenesis through AMPKα-PPARγ2 in 3T3-L1 cells and modulates fat accumulation in obese mice. Planta medica. 2012 Sep; 78(14):1536-42. doi: 10.1055/s-0032-1315147. [PMID: 22872592]
  • Boubacar Benziane, Marie Björnholm, Sergej Pirkmajer, Reginald L Austin, Olga Kotova, Benoit Viollet, Juleen R Zierath, Alexander V Chibalin. Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. The Journal of biological chemistry. 2012 Jul; 287(28):23451-63. doi: 10.1074/jbc.m111.331926. [PMID: 22610379]
  • J Lempiäinen, P Finckenberg, J Levijoki, E Mervaala. AMPK activator AICAR ameliorates ischaemia reperfusion injury in the rat kidney. British journal of pharmacology. 2012 Jul; 166(6):1905-15. doi: 10.1111/j.1476-5381.2012.01895.x. [PMID: 22324445]
  • Fei-Wang, De-Run Tian, Patrick Tso, Ji-Sheng Han. Diet-induced obese rats exhibit impaired LKB1-AMPK signaling in hypothalamus and adipose tissue. Peptides. 2012 May; 35(1):23-30. doi: 10.1016/j.peptides.2012.02.003. [PMID: 22465622]
  • M F Chen, T T Yang, L R Yeh, H H Chung, Y J Wen, W J Lee, J T Cheng. Activation of imidazoline I-2B receptors by allantoin to increase glucose uptake into C₂C₁₂ cells. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 2012 Apr; 44(4):268-72. doi: 10.1055/s-0032-1301898. [PMID: 22351479]
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  • Bobby Bhatia, Chad R Potts, Cemile Guldal, SunPhil Choi, Andrey Korshunov, Stefan Pfister, Anna M Kenney, Zaher A Nahlé. Hedgehog-mediated regulation of PPARγ controls metabolic patterns in neural precursors and shh-driven medulloblastoma. Acta neuropathologica. 2012 Apr; 123(4):587-600. doi: 10.1007/s00401-012-0968-6. [PMID: 22407012]
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  • Seog Hyeon Youn, Jin Sun Lee, Myung Sun Lee, Eun Young Cha, Phuong Thien Thuong, Je Ryong Kim, Eil Sung Chang. Anticancer properties of pomolic acid-induced AMP-activated protein kinase activation in MCF7 human breast cancer cells. Biological & pharmaceutical bulletin. 2012; 35(1):105-10. doi: 10.1248/bpb.35.105. [PMID: 22223345]
  • Andrea Hirsch, Dagmar Hahn, Petra Kempná, Gaby Hofer, Primus E Mullis, Jean-Marc Nuoffer, Christa E Flück. Role of AMP-activated protein kinase on steroid hormone biosynthesis in adrenal NCI-H295R cells. PloS one. 2012; 7(1):e30956. doi: 10.1371/journal.pone.0030956. [PMID: 22295121]
  • Juan-Pablo Idrovo, Weng-Lang Yang, Akihisa Matsuda, Jeffrey Nicastro, Gene F Coppa, Ping Wang. Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury. Shock (Augusta, Ga.). 2012 Jan; 37(1):39-46. doi: 10.1097/shk.0b013e31823185d7. [PMID: 21841537]
  • Joshua D Stone, Avinash Narine, David A Tulis. Inhibition of vascular smooth muscle growth via signaling crosstalk between AMP-activated protein kinase and cAMP-dependent protein kinase. Frontiers in physiology. 2012; 3(?):409. doi: 10.3389/fphys.2012.00409. [PMID: 23112775]
  • Takeo Iwata, Hisaaki Taniguchi, Masamichi Kuwajima, Takako Taniguchi, Yuko Okuda, Akiko Sukeno, Kyoko Ishimoto, Noriko Mizusawa, Katsuhiko Yoshimoto. The action of D-dopachrome tautomerase as an adipokine in adipocyte lipid metabolism. PloS one. 2012; 7(3):e33402. doi: 10.1371/journal.pone.0033402. [PMID: 22428043]
  • John P Fitzgerald, Bijaya Nayak, Karthigayan Shanmugasundaram, William Friedrichs, Sunil Sudarshan, Assaad A Eid, Thomas DeNapoli, Dipen J Parekh, Yves Gorin, Karen Block. Nox4 mediates renal cell carcinoma cell invasion through hypoxia-induced interleukin 6- and 8- production. PloS one. 2012; 7(1):e30712. doi: 10.1371/journal.pone.0030712. [PMID: 22303451]
  • Khang Wei Ong, Annie Hsu, Benny Kwong Huat Tan. Chlorogenic acid stimulates glucose transport in skeletal muscle via AMPK activation: a contributor to the beneficial effects of coffee on diabetes. PloS one. 2012; 7(3):e32718. doi: 10.1371/journal.pone.0032718. [PMID: 22412912]
  • Fernanda M Cerqueira, Laura I Brandizzi, Fernanda M Cunha, Francisco R M Laurindo, Alicia J Kowaltowski. Serum from calorie-restricted rats activates vascular cell eNOS through enhanced insulin signaling mediated by adiponectin. PloS one. 2012; 7(2):e31155. doi: 10.1371/journal.pone.0031155. [PMID: 22319612]
  • Jinmi Lee, Seok-Woo Hong, Seoung Wan Chae, Dong Hoon Kim, Ji Hun Choi, Ji Cheol Bae, Se Eun Park, Eun-Jung Rhee, Cheol-Young Park, Ki-Won Oh, Sung-Woo Park, Sun-Woo Kim, Won-Young Lee. Exendin-4 improves steatohepatitis by increasing Sirt1 expression in high-fat diet-induced obese C57BL/6J mice. PloS one. 2012; 7(2):e31394. doi: 10.1371/journal.pone.0031394. [PMID: 22363635]
  • Carlos R Bueno Júnior, Lucas C Pantaleão, Vanessa A Voltarelli, Luiz Henrique M Bozi, Patricia Chakur Brum, Mayana Zatz. Combined effect of AMPK/PPAR agonists and exercise training in mdx mice functional performance. PloS one. 2012; 7(9):e45699. doi: 10.1371/journal.pone.0045699. [PMID: 23029189]
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  • Yong-Qiang Liu, Xin Cheng, Liang-Xia Guo, Chan Mao, Yi-Jie Chen, Hai-Xia Liu, Qi-Cai Xiao, Sheng Jiang, Zhu-Jun Yao, Guang-Biao Zhou. Identification of an annonaceous acetogenin mimetic, AA005, as an AMPK activator and autophagy inducer in colon cancer cells. PloS one. 2012; 7(10):e47049. doi: 10.1371/journal.pone.0047049. [PMID: 23056575]
  • Mohamed Kodiha, Dennis Ho-Wo-Cheong, Ursula Stochaj. Pharmacological AMP-kinase activators have compartment-specific effects on cell physiology. American journal of physiology. Cell physiology. 2011 Dec; 301(6):C1307-15. doi: 10.1152/ajpcell.00309.2011. [PMID: 21918180]
  • Jianling Xie, Godwin A Ponuwei, Claire E Moore, Gary B Willars, Andrew R Tee, Terence P Herbert. cAMP inhibits mammalian target of rapamycin complex-1 and -2 (mTORC1 and 2) by promoting complex dissociation and inhibiting mTOR kinase activity. Cellular signalling. 2011 Dec; 23(12):1927-35. doi: 10.1016/j.cellsig.2011.06.025. [PMID: 21763421]
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  • Yuichi Yokoyama, Kazuhiro Iguchi, Shigeyuki Usui, Kazuyuki Hirano. AMP-activated protein kinase modulates the gene expression of aquaporin 9 via forkhead box a2. Archives of biochemistry and biophysics. 2011 Nov; 515(1-2):80-8. doi: 10.1016/j.abb.2011.08.002. [PMID: 21867676]
  • Mamoru Tanida, Naoki Yamamoto. Central AMP-activated protein kinase affects sympathetic nerve activity in rats. Neuroscience letters. 2011 Oct; 503(3):167-70. doi: 10.1016/j.neulet.2011.08.013. [PMID: 21893163]
  • Marlies Bosselaar, Paul Smits, Luc J C van Loon, Cees J Tack. Intravenous AICAR during hyperinsulinemia induces systemic hemodynamic changes but has no local metabolic effect. Journal of clinical pharmacology. 2011 Oct; 51(10):1449-58. doi: 10.1177/0091270010382912. [PMID: 21148051]
  • Anita Thyagarajan-Sahu, Brandon Lane, Daniel Sliva. ReishiMax, mushroom based dietary supplement, inhibits adipocyte differentiation, stimulates glucose uptake and activates AMPK. BMC complementary and alternative medicine. 2011 Sep; 11(?):74. doi: 10.1186/1472-6882-11-74. [PMID: 21929808]
  • Eun-Jeong Jung, Sung-Won Kwon, Byung-Hwa Jung, Seon-Hee Oh, Byung-Hoon Lee. Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. Journal of lipid research. 2011 Sep; 52(9):1617-25. doi: 10.1194/jlr.m015263. [PMID: 21757781]
  • Mandeep P Gaidhu, Andrea Frontini, Steven Hung, Kathryn Pistor, Saverio Cinti, Rolando B Ceddia. Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity. Journal of lipid research. 2011 Sep; 52(9):1702-11. doi: 10.1194/jlr.m015354. [PMID: 21737753]
  • Yanzhuo Ma, Yi Liu, Shaowei Liu, Yan Qu, Rutao Wang, Chenhai Xia, Haifeng Pei, Kun Lian, Tao Yin, Xiaoyan Lu, Lu Sun, Lu Yang, Yanjie Cao, Wayne Bond Lau, Erhe Gao, Haichang Wang, Ling Tao. Dynamic alteration of adiponectin/adiponectin receptor expression and its impact on myocardial ischemia/reperfusion in type 1 diabetic mice. American journal of physiology. Endocrinology and metabolism. 2011 Sep; 301(3):E447-55. doi: 10.1152/ajpendo.00687.2010. [PMID: 21586697]
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  • Laura K M Steinbusch, Robert W Schwenk, D Margriet Ouwens, Michaela Diamant, Jan F C Glatz, Joost J F P Luiken. Subcellular trafficking of the substrate transporters GLUT4 and CD36 in cardiomyocytes. Cellular and molecular life sciences : CMLS. 2011 Aug; 68(15):2525-38. doi: 10.1007/s00018-011-0690-x. [PMID: 21547502]
  • Amber P Sanchez, JingHong Zhao, Young You, Anne-Emilie Declèves, Maggie Diamond-Stanic, Kumar Sharma. Role of the USF1 transcription factor in diabetic kidney disease. American journal of physiology. Renal physiology. 2011 Aug; 301(2):F271-9. doi: 10.1152/ajprenal.00221.2011. [PMID: 21543418]
  • Jean-Baptiste Menassol, Claire Tautou, Armelle Collet, Didier Chesneau, Didier Lomet, Joëlle Dupont, Benoît Malpaux, Rex J Scaramuzzi. The effect of an intracerebroventricular injection of metformin or AICAR on the plasma concentrations of melatonin in the ewe: potential involvement of AMPK?. BMC neuroscience. 2011 Jul; 12(?):76. doi: 10.1186/1471-2202-12-76. [PMID: 21801416]
  • Jimmy R Thériault, Helen J Palmer, Debra D Pittman. Inhibition of the Unfolded Protein Response by metformin in renal proximal tubular epithelial cells. Biochemical and biophysical research communications. 2011 Jun; 409(3):500-5. doi: 10.1016/j.bbrc.2011.05.034. [PMID: 21600878]
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  • Zeqin Lian, Yan Li, Jian Gao, Kai Qu, Jin Li, Linghua Hao, Song Wu, Haibo Zhu. A novel AMPK activator, WS070117, improves lipid metabolism discords in hamsters and HepG2 cells. Lipids in health and disease. 2011 Apr; 10(?):67. doi: 10.1186/1476-511x-10-67. [PMID: 21529359]
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  • Yun Wang, Zeyu Wu, Dan Li, Duan Wang, Xiaoming Wang, Xiang Feng, Min Xia. Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress. The Journal of biological chemistry. 2011 Apr; 286(13):11119-31. doi: 10.1074/jbc.m110.203323. [PMID: 21296878]
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