Benzidine (BioDeep_00000002262)

   

human metabolite


代谢物信息卡片


4-Amino[1,1-biphenyl]-4-ylamine (acd/name 4.0)

化学式: C12H12N2 (184.1000432)
中文名称: 联苯胺, 联苯胺标准溶液
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C2=CC=C(C=C2)N)N
InChI: InChI=1S/C12H12N2/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-8H,13-14H2

描述信息

Benzidine is prepared in a two step process from nitrobenzene. First, the nitrobenzene is converted to 1,2-diphenylhydrazine, usually using iron powder as the reducing agent. Treatment of this hydrazine with mineral acids induces a rearrangement reaction to 4,4-benzidine. Smaller amounts of other isomers are also formed. The benzidine rearrangement, which proceeds intramolecularly, is a classic mechanistic puzzle in organic chemistry. Benzidine, the trivial name for 4,4-diaminobiphenyl, is the solid organic compound with the formula (C6H4NH2)2. This aromatic amine is a component of a test for cyanide and also in the production of dyes. Benzidine has been linked to bladder and pancreatic cancer. Since August 2010 benzidine dyes are included in the EPAs List of Chemicals of Concern.

同义名列表

31 个代谢物同义名

4-Amino[1,1-biphenyl]-4-ylamine (acd/name 4.0); [1,1-Biphenyl]-4,4-diamine (acd/name 4.0); C.I. azoic diazo component 112; {[1,} 1-biphenyl]-4,4-diamine; [1,1-Biphenyl]-4,4-diamine; (1,1-Biphenyl)-4,4-diamine; Biphenyl -4,4-ylenediamine; Benzidine dihydrochloride; 4,4-Diamino-1,1-biphenyl; 4-(4-aminophenyl)aniline; 4, 4-Biphenylenediamine; Benzidine hydrochloride; Rcra waste number u021; 4,4-Diphenylenediamine; 4,4-Biphenylenediamine; Benzidine monosulfate; p,P-diaminobiphenyl; 4,4-Diaminobiphenyl; 4,4-Diaminodiphenyl; 4,4-Biphenyldiamine; p,P-diaminodiphenyl; Fast corinth base b; p-Diaminodiphenyl; Benzidine acetate; p,P-bianiline; p,P-dianiline; p,p-Bianiline; 4,4-Bianiline; BENZIDINE; Benzidine; Benzidine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Melissa L Millerick-May, Ling Wang, Carol Rice, Kenneth D Rosenman. Ongoing risk of bladder cancer among former workers at the last benzidine manufacturing facility in the USA. Occupational and environmental medicine. 2021 09; 78(9):625-631. doi: 10.1136/oemed-2020-106431. [PMID: 33972377]
  • Jun Feng, Hao Lu, Yu Yang, Wenyi Huang, Hao Cheng, Hongxing Kong, Lijun Li. SERS-ELISA determination of human carboxylesterase 1 using metal-organic framework doped with gold nanoparticles as SERS substrate. Mikrochimica acta. 2021 07; 188(8):280. doi: 10.1007/s00604-021-04928-5. [PMID: 34331134]
  • Lei Chen, Mingyue Zhang, Fengfu Fu, Jingguang Li, Zian Lin. Facile synthesis of magnetic covalent organic framework nanobeads and application to magnetic solid-phase extraction of trace estrogens from human urine. Journal of chromatography. A. 2018 Sep; 1567(?):136-146. doi: 10.1016/j.chroma.2018.06.066. [PMID: 30100013]
  • Sowbiya Muneer, Hao Wei, Yoo Gyeong Park, Hai Kyoung Jeong, Byoung Ryong Jeong. Proteomic Analysis Reveals the Dynamic Role of Silicon in Alleviation of Hyperhydricity in Carnation Grown In Vitro. International journal of molecular sciences. 2017 Dec; 19(1):. doi: 10.3390/ijms19010050. [PMID: 29295554]
  • Yi-Wei Wang, Shurong Tang, Huang-Hao Yang, Hongbo Song. A novel colorimetric assay for rapid detection of cysteine and Hg²⁺ based on gold clusters. Talanta. 2016; 146(?):71-4. doi: 10.1016/j.talanta.2015.08.015. [PMID: 26695236]
  • Il Hak Bae, Hee Sun Kim, Youngsu You, Chieyeon Chough, Weonu Choe, Min Kyung Seon, Seung Gi Lee, Gyochang Keum, Sung Key Jang, B Moon Kim. Novel benzidine and diaminofluorene prolinamide derivatives as potent hepatitis C virus NS5A inhibitors. European journal of medicinal chemistry. 2015 Aug; 101(?):163-78. doi: 10.1016/j.ejmech.2015.06.033. [PMID: 26134551]
  • Qing-wen Ma, Guo-fang Lin, Ji-gang Chen, Wei-Chao Guo, Yi-qiu Qin, Klaus Golka, Jian-hua Shen. N-Acetyltransferase 2 genotype, exfoliated urothelial cells and benzidine exposure. Frontiers in bioscience (Elite edition). 2012 01; 4(5):1966-74. doi: 10.2741/517. [PMID: 22202012]
  • Katalin Kiss, Anna Brozik, Nora Kucsma, Alexandra Toth, Melinda Gera, Laurence Berry, Alice Vallentin, Henri Vial, Michel Vidal, Gergely Szakacs. Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. PloS one. 2012; 7(5):e37378. doi: 10.1371/journal.pone.0037378. [PMID: 22655043]
  • Erin D Scully, Kelli Hoover, John Carlson, Ming Tien, Scott M Geib. Proteomic analysis of Fusarium solani isolated from the Asian longhorned beetle, Anoplophora glabripennis. PloS one. 2012; 7(4):e32990. doi: 10.1371/journal.pone.0032990. [PMID: 22496740]
  • Melissa Simpson, Janet K Snell-Bergeon, Gregory L Kinney, Orit Lache, Rachel Miller-Lotan, Yefim Anbinder, Marian J Rewers, Andrew P Levy. Haptoglobin genotype predicts development of coronary artery calcification in a prospective cohort of patients with type 1 diabetes. Cardiovascular diabetology. 2011 Nov; 10(?):99. doi: 10.1186/1475-2840-10-99. [PMID: 22098782]
  • Lei Zhang, Shanshan Xiao, Wenqi Li, Wei Feng, Juan Li, Zhidan Wu, Xuewen Gao, Fengquan Liu, Min Shao. Overexpression of a Harpin-encoding gene hrf1 in rice enhances drought tolerance. Journal of experimental botany. 2011 Aug; 62(12):4229-38. doi: 10.1093/jxb/err131. [PMID: 21527628]
  • J G Hengstler, H Foth, T Gebel, P-J Kramer, W Lilienblum, H Schweinfurth, W Völkel, K-M Wollin, U Gundert-Remy. Critical evaluation of key evidence on the human health hazards of exposure to bisphenol A. Critical reviews in toxicology. 2011 Apr; 41(4):263-91. doi: 10.3109/10408444.2011.558487. [PMID: 21438738]
  • Rong Xu, Weicheng Zhu, Jun Chen, Xia Wang, Tongning Liu. [Pollen viability and stigma receptivity of Cistanche deserticola]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Feb; 36(3):307-10. doi: ". [PMID: 21585032]
  • Emmanuelle Boeglin, Cristian R Smulski, Susana Brun, Sara Milosevic, Pascal Schneider, Sylvie Fournel. Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells. PloS one. 2011; 6(10):e25542. doi: 10.1371/journal.pone.0025542. [PMID: 21991317]
  • Eugenia Prus, Eitan Fibach. Uptake of non-transferrin iron by erythroid cells. Anemia. 2011; 2011(?):945289. doi: 10.1155/2011/945289. [PMID: 21490768]
  • Ashutosh Verma, Pawan Kumar, Kelly Babb, John F Timoney, Brian Stevenson. Cross-reactivity of antibodies against leptospiral recurrent uveitis-associated proteins A and B (LruA and LruB) with eye proteins. PLoS neglected tropical diseases. 2010 Aug; 4(8):e778. doi: 10.1371/journal.pntd.0000778. [PMID: 20689825]
  • Adam Takos, Daniela Lai, Lisbeth Mikkelsen, Maher Abou Hachem, Dale Shelton, Mohammed Saddik Motawia, Carl Erik Olsen, Trevor L Wang, Cathie Martin, Fred Rook. Genetic screening identifies cyanogenesis-deficient mutants of Lotus japonicus and reveals enzymatic specificity in hydroxynitrile glucoside metabolism. The Plant cell. 2010 May; 22(5):1605-19. doi: 10.1105/tpc.109.073502. [PMID: 20453117]
  • Tracey Ruhlman, Dheeraj Verma, Nalapalli Samson, Henry Daniell. The role of heterologous chloroplast sequence elements in transgene integration and expression. Plant physiology. 2010 Apr; 152(4):2088-104. doi: 10.1104/pp.109.152017. [PMID: 20130101]
  • Ye-Zhong Zhang, Jie Dai, Xia Xiang, Wei-Wei Li, Yi Liu. Studies on the interaction between benzidine and bovine serum albumin by spectroscopic methods. Molecular biology reports. 2010 Mar; 37(3):1541-9. doi: 10.1007/s11033-009-9555-x. [PMID: 19437138]
  • Yanfang Wang, Liping Zhang, Xuegang Zhou, Guofeng Zhao, Xinwen Wang, Bing Wu. [Mating system and causes of low fructification rate by self-pollination of Codonopsis pilosula]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Feb; 35(3):279-82. doi: . [PMID: 20422988]
  • Min Tong, Liefeng Zhang, Yifan Wang, Hui Jiang, Yong Ren. Fe-chlorophyllin promotes the growth of wheat roots associated with nitric oxide generation. International journal of molecular sciences. 2010; 11(12):5246-55. doi: 10.3390/ijms11125246. [PMID: 21614205]
  • Ki Youn Kim, Jae Hoon Roh, Se Hoon Lee, Jong Uk Won, Chi Nyon Kim. Effects of ethanol and phenobarbital on hemoglobin adducts formation in rats exposed to benzidine and Direct Black 38. Industrial health. 2009 Aug; 47(4):383-92. doi: 10.2486/indhealth.47.383. [PMID: 19672012]
  • Nicoletta Bianchi, Cristina Zuccato, Ilaria Lampronti, Monica Borgatti, Roberto Gambari. Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia. Evidence-based complementary and alternative medicine : eCAM. 2009 Jun; 6(2):141-51. doi: 10.1093/ecam/nem139. [PMID: 18955291]
  • Hua Wang, Jun Wang, Daiwon Choi, Zhiwen Tang, Hong Wu, Yuehe Lin. EQCM immunoassay for phosphorylated acetylcholinesterase as a biomarker for organophosphate exposures based on selective zirconia adsorption and enzyme-catalytic precipitation. Biosensors & bioelectronics. 2009 Apr; 24(8):2377-83. doi: 10.1016/j.bios.2008.12.013. [PMID: 19135350]
  • Cheng-Shu Chung, Chiung-Hsiang Cheng, Shin-Chien Chin, An-Hsing Lee, Chau-Hwa Chi. Morphologic and cytochemical characteristics of Chinese striped-necked [corrected] turtle (Ocadia sinensis) blood cells and their hematologic and plasma biochemical reference values. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2009 Mar; 40(1):76-85. doi: 10.1638/2008-0023.1. [PMID: 19368243]
  • Eric A Lefevre, B Veronica Carr, Helen Prentice, Bryan Charleston. A quantitative assessment of primary and secondary immune responses in cattle using a B cell ELISPOT assay. Veterinary research. 2009 Jan; 40(1):3. doi: 10.1051/vetres:2008041. [PMID: 18828984]
  • Mookkan Prabakaran, Hui-Ting Ho, Nayana Prabhu, Sumathy Velumani, Milene Szyporta, Fang He, Kwai-Peng Chan, Li-Mei Chen, Yumiko Matsuoka, Ruben O Donis, Jimmy Kwang. Development of epitope-blocking ELISA for universal detection of antibodies to human H5N1 influenza viruses. PloS one. 2009; 4(2):e4566. doi: 10.1371/journal.pone.0004566. [PMID: 19238211]
  • S Milacic. Granulocytes' enzymes as biomarkers of radiotoxicity in individuals occupationally exposed to low-level radiation. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. 2009 Jan; 14(1):85-91. doi: NULL. [PMID: 19373952]
  • Carla Giannina Zilli, Diego Mario Santa-Cruz, Gustavo Gabriel Yannarelli, Guillermo Osvaldo Noriega, María Luján Tomaro, Karina Beatriz Balestrasse. Heme Oxygenase Contributes to Alleviate Salinity Damage in Glycine max L. Leaves. International journal of cell biology. 2009; 2009(?):848516. doi: 10.1155/2009/848516. [PMID: 20130761]
  • Bharathi Yarasi, Vijayakumar Sadumpati, China Pasalu Immanni, Dasavantha Reddy Vudem, Venkateswara Rao Khareedu. Transgenic rice expressing Allium sativum leaf agglutinin (ASAL) exhibits high-level resistance against major sap-sucking pests. BMC plant biology. 2008 Oct; 8(?):102. doi: 10.1186/1471-2229-8-102. [PMID: 18854007]
  • Vikas Kumar, Chandrajeetbalo Majumdar, Partha Roy. Effects of endocrine disrupting chemicals from leather industry effluents on male reproductive system. The Journal of steroid biochemistry and molecular biology. 2008 Sep; 111(3-5):208-16. doi: 10.1016/j.jsbmb.2008.06.005. [PMID: 18606229]
  • Amit Bafana, Kannan Krishnamurthi, Sivanesan Saravana Devi, Tapan Chakrabarti. Biological decolourization of C.I. Direct Black 38 by E. gallinarum. Journal of hazardous materials. 2008 Aug; 157(1):187-93. doi: 10.1016/j.jhazmat.2007.12.085. [PMID: 18280646]
  • Zhi-Mei Guo, Hai-Jun Li, Xin-Hua Qian. [Gamma-globin synthesis in K562 cells induced with Tortois plastron, Astragali, Salviae miltiorrhizae and Codonopsis pilosulae]. Zhongguo shi yan xue ye xue za zhi. 2008 Jun; 16(3):520-4. doi: ". [PMID: 18549621]
  • D Pascual, A Borque. Epidemiology of kidney cancer. Advances in urology. 2008; ?(?):782381. doi: 10.1155/2008/782381. [PMID: 19009036]
  • Patrudu S Makena, King-Thom Chung. Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007 Oct; 45(10):1899-909. doi: 10.1016/j.fct.2007.04.007. [PMID: 17560706]
  • Astrid Rehorek, Alexander Plum. Characterization of sulfonated azo dyes and aromatic amines by pyrolysis gas chromatography/mass spectrometry. Analytical and bioanalytical chemistry. 2007 Aug; 388(8):1653-62. doi: 10.1007/s00216-007-1390-0. [PMID: 17579845]
  • Cui-Qin Xiang, Chun-Lin Shen, Zi-Rong Wu, Yi-Qiu Qin, Yun-Ying Zhang, Cha-Zhen Liu, Ji-Gang Chen, Sheng-Nian Zhang. Detection of mutant p53 protein in workers occupationally exposed to benzidine. Journal of occupational health. 2007 Jul; 49(4):279-84. doi: 10.1539/joh.49.279. [PMID: 17690521]
  • Marialetizia Penza, Claudia Montani, Marija Jeremic, Giovanna Mazzoleni, W L Wendy Hsiao, Maurizio Marra, Hari Sharma, Diego Di Lorenzo. MAK-4 and -5 supplemented diet inhibits liver carcinogenesis in mice. BMC complementary and alternative medicine. 2007 Jun; 7(?):19. doi: 10.1186/1472-6882-7-19. [PMID: 17559639]
  • Patrudu Makena, King-Thom Chung. Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species. Environmental and molecular mutagenesis. 2007 Jun; 48(5):404-13. doi: 10.1002/em.20288. [PMID: 17370336]
  • Oluwatosin O Soyinka, Francis A Adeniyi, Olabamiji A Ajose. Biochemical parameters of liver function in artisans occupationally exposed to 'vat dyes'. Indian journal of occupational and environmental medicine. 2007 May; 11(2):76-9. doi: 10.4103/0019-5278.34533. [PMID: 21938220]
  • Amit Bafana, Sivanesan Saravana Devi, Kannan Krishnamurthi, Tapan Chakrabarti. Kinetics of decolourisation and biotransformation of direct black 38 by C. hominis and P. stutzeri. Applied microbiology and biotechnology. 2007 Apr; 74(5):1145-52. doi: 10.1007/s00253-006-0751-5. [PMID: 17318544]
  • Rodrigo Otávio Alves de Lima, Ana Paula Bazo, Daisy Maria Fávero Salvadori, Célia Maria Rech, Danielle de Palma Oliveira, Gisela de Aragão Umbuzeiro. Mutagenic and carcinogenic potential of a textile azo dye processing plant effluent that impacts a drinking water source. Mutation research. 2007 Jan; 626(1-2):53-60. doi: 10.1016/j.mrgentox.2006.08.002. [PMID: 17027325]
  • Bok-Rye Lee, Kil-Yong Kim, Woo-Jin Jung, Jean-Christophe Avice, Alain Ourry, Tae-Hwan Kim. Peroxidases and lignification in relation to the intensity of water-deficit stress in white clover (Trifolium repens L.). Journal of experimental botany. 2007; 58(6):1271-9. doi: 10.1093/jxb/erl280. [PMID: 17298963]
  • Armin Beyerbach, Nathaniel Rothman, Vijai K Bhatnagar, Rekha Kashyap, Gabriele Sabbioni. Hemoglobin adducts in workers exposed to benzidine and azo dyes. Carcinogenesis. 2006 Aug; 27(8):1600-6. doi: 10.1093/carcin/bgi362. [PMID: 16497705]
  • P Kalocheretis, I Vlamis, C Belesi, I Makriniotou, S Zerbala, E Savidou, S Zorbas, N Arvanitis, C Iatrou. Residual blood loss in single use dialyzers: effect of different membranes and flux. The International journal of artificial organs. 2006 Mar; 29(3):286-92. doi: 10.1177/039139880602900306. [PMID: 16685672]
  • Qing Wu, Zheng-chang Heng. [Study of rat's p53 gene damage and organ specificity induced by benzidine]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2006 Jan; 37(1):33-4, 39. doi: NULL. [PMID: 16468636]
  • M A Bellimam, A Stambouli, N El Karni, T Bouayoun, A El Bouri. Analysis of paraphenylenediamine. Acta clinica Belgica. 2006; 61 Suppl 1(?):41-7. doi: 10.1179/acb.2006.068. [PMID: 16700150]
  • Anna M Vetrano, Diane E Heck, Thomas M Mariano, Vladimir Mishin, Debra L Laskin, Jeffrey D Laskin. Characterization of the oxidase activity in mammalian catalase. The Journal of biological chemistry. 2005 Oct; 280(42):35372-81. doi: 10.1074/jbc.m503991200. [PMID: 16079130]
  • Hugh A Barton, V James Cogliano, Lynn Flowers, Larry Valcovic, R Woodrow Setzer, Tracey J Woodruff. Assessing susceptibility from early-life exposure to carcinogens. Environmental health perspectives. 2005 Sep; 113(9):1125-33. doi: 10.1289/ehp.7667. [PMID: 16140616]
  • Fatimah Eliana, Czeresna H Soejono, Abidin Widjanarko, Zuljasri Albar, Adang Bachtiar. Iron deposit state and risk factors for anemia in the elderly. Acta medica Indonesiana. 2005 Jul; 37(3):118-25. doi: NULL. [PMID: 16138416]
  • Guo-Fang Lin, Wei-Chao Guo, Ji-Gang Chen, Yi-Qing Qin, Klaus Golka, Cui-Qing Xiang, Qing-Wen Ma, Da-Ru Lu, Jian-Hua Shen. An association of UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine-exposed workers in China. Toxicological sciences : an official journal of the Society of Toxicology. 2005 May; 85(1):502-6. doi: 10.1093/toxsci/kfi068. [PMID: 15615884]
  • Xian-hao Wen, You-hua Xu. [Differentiation of K562 cells induced by antisense oligonucleotide targeting survivin]. Zhonghua er ke za zhi = Chinese journal of pediatrics. 2005 Apr; 43(4):279-83. doi: . [PMID: 15924721]
  • Chun-lin Shen, Cui-qin Xiang, Yun-ying Zhang, Yi-qiu Qin, Cha-qin Liu, Ji-gang Chen, Sheng-nian Zhang. [Expression of protein p53 in workers occupationally exposed to benzidine and bladder cancer patients.]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2005 Feb; 23(1):31-4. doi: . [PMID: 15748509]
  • Sha Wang, Yu-bo Chai, Fei Liu, Xiao-yong Zhang, Wei Jia, Xin Xie, Wen-qiang Yu, Zhen-chuan Shang, Bo-quan Jin, Bing-zhong Sun. [Effect of specific siRNA targeting against bcr-abl chimeric gene on chronic myelogenous leukemia cells]. Zhonghua yi xue za zhi. 2005 Jan; 85(3):198-202. doi: . [PMID: 15854468]
  • S Arikan, T Akcay, D Konukoglu, C Obek, A R Kural. The relationship between antioxidant enzymes and bladder cancer. Neoplasma. 2005; 52(4):314-7. doi: . [PMID: 16059648]
  • A Stambouli, M A Bellimam, N El Karni, T Bouayoun, A El Bouri. Optimization of an analytical method for detecting paraphenylenediamine (PPD) by GC/MS-iontrap in biological liquids. Forensic science international. 2004 Dec; 146 Suppl(?):S87-92. doi: 10.1016/j.forsciint.2004.09.029. [PMID: 15639598]
  • Qing-Wen Ma, Guo-Fang Lin, Ji-Gang Chen, Cui-Qing Xiang, Wei-Chao Guo, Klaus Golka, Jian-Hua Shen. Polymorphism of N-acetyltransferase 2 (NAT2) gene polymorphism in shanghai population: occupational and non-occupational bladder cancer patient groups. Biomedical and environmental sciences : BES. 2004 Sep; 17(3):291-8. doi: . [PMID: 15602826]
  • P D Hardt, S Mazurek, M Toepler, P Schlierbach, R G Bretzel, E Eigenbrodt, H U Kloer. Faecal tumour M2 pyruvate kinase: a new, sensitive screening tool for colorectal cancer. British journal of cancer. 2004 Aug; 91(5):980-4. doi: 10.1038/sj.bjc.6602033. [PMID: 15266315]
  • Frederica P Perera, Deliang Tang, Yi-Hsuan Tu, Linda Ali Cruz, Mejico Borjas, Tom Bernert, Robin M Whyatt. Biomarkers in maternal and newborn blood indicate heightened fetal susceptibility to procarcinogenic DNA damage. Environmental health perspectives. 2004 Jul; 112(10):1133-6. doi: 10.1289/ehp.6833. [PMID: 15238289]
  • Klaus Golka, Silke Kopps, Zdislaw W Myslak. Carcinogenicity of azo colorants: influence of solubility and bioavailability. Toxicology letters. 2004 Jun; 151(1):203-10. doi: 10.1016/j.toxlet.2003.11.016. [PMID: 15177655]
  • Klaus Golka, Andreas Wiese, Giorgio Assennato, Hermann M Bolt. Occupational exposure and urological cancer. World journal of urology. 2004 Feb; 21(6):382-91. doi: 10.1007/s00345-003-0377-5. [PMID: 14648102]
  • Gauri Patel, Y K Agrawal. Separation and trace estimation of benzidine and its macromolecular adducts using supercritical fluid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Oct; 795(2):157-65. doi: 10.1016/s1570-0232(03)00558-0. [PMID: 14522020]
  • William H Waugh. Simplified method to assay total plasma peroxidase activity and ferriheme products in sickle cell anemia, with initial results in assessing clinical severity in a trial with citrulline therapy. Journal of pediatric hematology/oncology. 2003 Oct; 25(10):831-4. doi: 10.1097/00043426-200310000-00021. [PMID: 14528113]
  • Juozas Kulys, Regina Vidziunaite. Amperometric biosensors based on recombinant laccases for phenols determination. Biosensors & bioelectronics. 2003 Mar; 18(2-3):319-25. doi: 10.1016/s0956-5663(02)00172-0. [PMID: 12485779]
  • I Pavan, C Baroffio, E Buglione, V Passini, E Pira. [Aromatic amines with certain, probable, or possible carcinogenic action: reference values]. Giornale italiano di medicina del lavoro ed ergonomia. 2003 Jan; 25(1):68-73. doi: . [PMID: 12696487]
  • Young H Ju, Michael J Plewa. Mutant spectra analysis at hisG46 in Salmonella typhimurium strain YG1029 induced by mammalian S9- and plant-activated aromatic amines. Teratogenesis, carcinogenesis, and mutagenesis. 2003; Suppl 1(?):47-60. doi: 10.1002/tcm.10061. [PMID: 12616596]
  • Terry V Zenser, Vijaya M Lakshmi, Fong Fu Hsu, Bernard B Davis. Metabolism of N-acetylbenzidine and initiation of bladder cancer. Mutation research. 2002 Sep; 506-507(?):29-40. doi: 10.1016/s0027-5107(02)00149-5. [PMID: 12351142]
  • Qing-Wen Ma, Guo-Fang Lin, Ji-Gang Chen, Jian-Hua Shen. Polymorphism of glutathione S-transferase T1, M1 and P1 genes in a Shanghai population: patients with occupational or non-occupational bladder cancer. Biomedical and environmental sciences : BES. 2002 Sep; 15(3):253-60. doi: . [PMID: 12500666]
  • Glenn Talaska, Andrew Maier, Scott Henn, Angela Booth-Jones, Yutaka Tsuneoka, Roel Vermeulen, Brenda L Schumann. Carcinogen biomonitoring in human exposures and laboratory research: validation and application to human occupational exposures. Toxicology letters. 2002 Aug; 134(1-3):39-49. doi: 10.1016/s0378-4274(02)00161-3. [PMID: 12191859]
  • Akheel A Syed, Mohammed F Silwadi, Bibi A Khatoon. Imipramine hydrochloride and desipramine hydrochloride as new reagents for detection of microamounts of blood in urine. Journal of pharmaceutical and biomedical analysis. 2002 May; 28(3-4):501-7. doi: 10.1016/s0731-7085(01)00665-3. [PMID: 12008129]
  • J Hu, Y Mao, K White. Renal cell carcinoma and occupational exposure to chemicals in Canada. Occupational medicine (Oxford, England). 2002 May; 52(3):157-64. doi: 10.1093/occmed/52.3.157. [PMID: 12063361]
  • Klaus Golka, Verena Prior, Meinolf Blaszkewicz, Hermann M Bolt. The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: a review considering ethnic differences. Toxicology letters. 2002 Mar; 128(1-3):229-41. doi: 10.1016/s0378-4274(01)00544-6. [PMID: 11869833]
  • Dong-Sheng Zhang, Guo-Fang Lin, Qing-Wen Ma, Jian-Hua Shen. Nonassociation of aryl hydrocarbon receptor genotypes with susceptibility to bladder cancer in Shanghai population. Acta pharmacologica Sinica. 2002 Feb; 23(2):188-92. doi: ". [PMID: 11866883]
  • Min Zheng, Ya-ping Wang. [Experimental study on effect of Angelica polysaccharide in inhibitory proliferation and inducing differentiation of K562 cells]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2002 Jan; 22(1):54-7. doi: ". [PMID: 12585175]
  • Peter Kayatz, Gabriele Thumann, Ulrich Schraermeyer. Ultrastructural localization of light-induced lipid peroxides. Methods in enzymology. 2002; 352(?):378-91. doi: 10.1016/s0076-6879(02)52035-8. [PMID: 12125365]
  • N A Bagirova, T N Shekhovtsova, R B van Huystee. Enzymatic determination of phenols using peanut peroxidase. Talanta. 2001 Dec; 55(6):1151-64. doi: 10.1016/s0039-9140(01)00544-6. [PMID: 18968468]
  • G Lin, Q Ma, J Chen, J Shen, C Xiang, K Golka, D Zhang. Dependence of papanicolaou gradings of exfoliated urothelial cells upon GSTM1 and GSTT1 polymorphism in benzidine-exposed workers of the Shanghai dye industry. Archives of toxicology. 2001 Nov; 75(9):544-8. doi: 10.1007/s00204-001-0281-y. [PMID: 11760815]
  • R Thier, J Lewalter, S Selinski, H M Bolt. Biological monitoring in workers in a nitrobenzene reduction plant: haemoglobin versus serum albumin adducts. International archives of occupational and environmental health. 2001 Sep; 74(7):483-8. doi: 10.1007/s004200100250. [PMID: 11697451]
  • M Miyakawa, M Tachibana, A Miyakawa, K Yoshida, N Shimada, M Murai, T Kondo. Re-evaluation of the latent period of bladder cancer in dyestuff-plant workers in Japan. International journal of urology : official journal of the Japanese Urological Association. 2001 Aug; 8(8):423-30. doi: 10.1046/j.1442-2042.2001.00342.x. [PMID: 11555006]
  • G P Hemstreet, S Yin, Z Ma, R B Bonner, W Bi, J Y Rao, M Zang, Q Zheng, B Bane, N Asal, G Li, P Feng, R E Hurst, W Wang. Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine. Journal of the National Cancer Institute. 2001 Mar; 93(6):427-36. doi: 10.1093/jnci/93.6.427. [PMID: 11259468]
  • T V Zenser, V M Lakshmi, B B Davis. Human and Escherichia coli beta-glucuronidase hydrolysis of glucuronide conjugates of benzidine and 4-aminobiphenyl, and their hydroxy metabolites. Drug metabolism and disposition: the biological fate of chemicals. 1999 Sep; 27(9):1064-7. doi: . [PMID: 10460807]
  • P Kayatz, K Heimann, U Schraermeyer. Tracing of benzidine-reactive substances in ROS, RPE and choroid after light-induced peroxidation. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 1999 Sep; 237(9):763-74. doi: 10.1007/s004170050310. [PMID: 10447653]
  • P Roy, A P Kulkarni. Co-oxidation of acrylonitrile by soybean lipoxygenase and partially purified human lung lipoxygenase. Xenobiotica; the fate of foreign compounds in biological systems. 1999 May; 29(5):511-31. doi: 10.1080/004982599238515. [PMID: 10379988]
  • H Yamada, J Horiguchi-Yamada, M Nagai, S Takahara, T Sekikawa, T Kawano, K Itoh, S Fukumi, S Iwase. Biological effects of a relatively low concentration of 1-beta-D-arabinofuranosylcytosine in K562 cells: alterations of the cell cycle, erythroid-differentiation, and apoptosis. Molecular and cellular biochemistry. 1998 Oct; 187(1-2):211-20. doi: 10.1023/a:1006874931249. [PMID: 9788759]
  • T V Zenser, V M Lakshmi, B B Davis. N-glucuronidation of benzidine and its metabolites. Role in bladder cancer. Drug metabolism and disposition: the biological fate of chemicals. 1998 Sep; 26(9):856-9. doi: . [PMID: 9733663]
  • N Rothman, G Talaska, R B Hayes, V K Bhatnagar, D A Bell, V M Lakshmi, S K Kashyap, M Dosemeci, R Kashyap, F F Hsu, M Jaeger, A Hirvonen, D J Parikh, B B Davis, T V Zenser. Acidic urine pH is associated with elevated levels of free urinary benzidine and N-acetylbenzidine and urothelial cell DNA adducts in exposed workers. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 1997 Dec; 6(12):1039-42. doi: . [PMID: 9419400]
  • Y Morikawa, K Shiomi, Y Ishihara, N Matsuura. Triple primary cancers involving kidney, urinary bladder, and liver in a dye worker. American journal of industrial medicine. 1997 Jan; 31(1):44-9. doi: 10.1002/(sici)1097-0274(199701)31:1<44::aid-ajim7>3.0.co;2-x. [PMID: 8986253]
  • Y H Ju, M J Plewa. Plant-activation of the bicyclic aromatic amines benzidine and 4-aminobiphenyl. Environmental and molecular mutagenesis. 1997; 29(1):81-90. doi: . [PMID: 9020311]
  • Y H Ju, M J Plewa. Involvement of nitroreductase and O-acetyltransferase on the mutagenicity of plant-activated benzidine and 4-aminobiphenyl. Environmental and molecular mutagenesis. 1997; 30(3):330-8. doi: 10.1002/(sici)1098-2280(1997)30:3<330::aid-em12>3.0.co;2-e. [PMID: 9366912]
  • N Rothman, R B Hayes, T V Zenser, D M DeMarini, W Bi, A Hirvonen, G Talaska, V K Bhatnagar, N E Caporaso, L R Brooks, V M Lakshmi, P Feng, S K Kashyap, X You, B T Eischen, R Kashyap, M L Shelton, F F Hsu, M Jaeger, D J Parikh, B B Davis, S Yin, D A Bell. The glutathione S-transferase M1 (GSTM1) null genotype and benzidine-associated bladder cancer, urine mutagenicity, and exfoliated urothelial cell DNA adducts. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 1996 Dec; 5(12):979-83. doi: . [PMID: 8959320]
  • F F Hsu, V Lakshmi, N Rothman, V K Bhatnager, R B Hayes, R Kashyap, D J Parikh, S K Kashyap, J Turk, T Zenser, B Davis. Determination of benzidine, N-acetylbenzidine, and N,N'-diacetylbenzidine in human urine by capillary gas chromatography/negative ion chemical ionization mass spectrometry. Analytical biochemistry. 1996 Feb; 234(2):183-9. doi: 10.1006/abio.1996.0070. [PMID: 8714596]
  • J Whysner, L Verna, G M Williams. Benzidine mechanistic data and risk assessment: species- and organ-specific metabolic activation. Pharmacology & therapeutics. 1996; 71(1-2):107-26. doi: 10.1016/0163-7258(96)00064-2. [PMID: 8910951]
  • T Tanigawa, S Araki, T Abo, S Sakurai. Increase in CD57 + CD16-lymphocytes in workers exposed to benzidine and beta-naphthylamine: assessment of natural killer cell subpopulations. International archives of occupational and environmental health. 1996; 69(1):69-72. doi: . [PMID: 9017438]
  • P Vineis. Epidemiology of cancer from exposure to arylamines. Environmental health perspectives. 1994 Oct; 102 Suppl 6(?):7-10. doi: 10.1289/ehp.94102s67. [PMID: 7889862]
  • E D Wagner, S R Smith, H Xin, M J Plewa. Comparative mutagenicity of plant-activated aromatic amines using Salmonella strains with different acetyltransferase activities. Environmental and molecular mutagenesis. 1994; 23(1):64-9. doi: 10.1002/em.2850230110. [PMID: 8125084]
  • R M el Gazzar, H Abdel Hamid, M Y Shamy. Biological monitoring of occupational exposure to electrophilic compounds. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer. 1994; 13(1):19-23. doi: NULL. [PMID: 7529835]
  • S Araki, T Tanigawa, S Ishizu, N Minato. Decrease of CD4-positive T lymphocytes in workers exposed to benzidine and beta-naphthylamine. Archives of environmental health. 1993 Jul; 48(4):205-8. doi: 10.1080/00039896.1993.9940360. [PMID: 8102843]
  • S R Babu, V M Lakshmi, F F Hsu, T V Zenser, B B Davis. Role of N-glucuronidation in benzidine-induced bladder cancer in dog. Carcinogenesis. 1992 Jul; 13(7):1235-40. doi: 10.1093/carcin/13.7.1235. [PMID: 1638692]
  • A Cohen, J K Boeijinga, P M van Haard, R C Schoemaker, A van Vliet-Verbeek. Gastrointestinal blood loss after non-steroidal anti-inflammatory drugs. Measurement by selective determination of faecal porphyrins. British journal of clinical pharmacology. 1992 Jan; 33(1):33-8. doi: 10.1111/j.1365-2125.1992.tb03997.x. [PMID: 1540488]