Arbutin (BioDeep_00000000220)

 

Secondary id: BioDeep_00000406115

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol

化学式: C12H16O7 (272.0896)
中文名称: 楊梅葉甘, 熊果叶甙, 熊果酚甙, 熊果苷, 熊果素
谱图信息: 最多检出来源 Homo sapiens(otcml) 4.03%

分子结构信息

SMILES: C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O
InChI: InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1

描述信息

Hydroquinone O-beta-D-glucopyranoside is a monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage. It has a role as a plant metabolite and an Escherichia coli metabolite. It is a beta-D-glucoside and a monosaccharide derivative. It is functionally related to a hydroquinone.
Extracted from the dried leaves of bearberry plant in the genus Arctostaphylos and other plants commonly in the Ericaceae family, arbutin is a beta-D-glucopyranoside of [DB09526]. It is found in foods, over-the-counter drugs, and herbal dietary supplements. Most commonly, it is an active ingredient in skincare and cosmetic products as a skin-lightening agent for the prevention of melanin formation in various skin conditions that involve cutaneous hyperpigmentation or hyperactive melanocyte function. It has also been used as an anti-infective for the urinary system as well as a diuretic. Arbutin is available in both natural and synthetic forms; it can be synthesized from acetobromglucose and [DB09526]. Arbutin is a competitive inhibitor of tyrosinase (E.C.1.14.18.1) in melanocytes, and the inhibition of melanin synthesis at non-toxic concentrations was observed in vitro. Arbutin was shown to be less cytotoxic to melanocytes in culture compared to [DB09526].
Arbutin is a natural product found in Grevillea robusta, Halocarpus biformis, and other organisms with data available.
See also: Arctostaphylos uva-ursi leaf (part of); Arbutin; octinoxate (component of); Adenosine; arbutin (component of) ... View More ...
Arbutin, also known as hydroquinone-O-beta-D-glucopyranoside or P-hydroxyphenyl beta-D-glucopyranoside, is a member of the class of compounds known as phenolic glycosides. Phenolic glycosides are organic compounds containing a phenolic structure attached to a glycosyl moiety. Some examples of phenolic structures include lignans, and flavonoids. Among the sugar units found in natural glycosides are D-glucose, L-Fructose, and L rhamnose. Arbutin is soluble (in water) and a very weakly acidic compound (based on its pKa). Arbutin can be found in a number of food items such as guava, lingonberry, irish moss, and rowal, which makes arbutin a potential biomarker for the consumption of these food products. Arbutin is a glycoside; a glycosylated hydroquinone extracted from the bearberry plant in the genus Arctostaphylos among many other medicinal plants, primarily in the Ericaceae family. Applied topically, it inhibits tyrosinase and thus prevents the formation of melanin. Arbutin is therefore used as a skin-lightening agent. Very tiny amounts of arbutin are found in wheat, pear skins, and some other foods. It is also found in Bergenia crassifolia. Arbutin was also produced by an in vitro culture of Schisandra chinensis .
A monosaccharide derivative that is hydroquinone attached to a beta-D-glucopyranosyl residue at position 4 via a glycosidic linkage.
Arbutin is found in apple. Glucoside in pear leaves (Pyrus communis
C471 - Enzyme Inhibitor
CONFIDENCE standard compound; INTERNAL_ID 1335; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6126; ORIGINAL_PRECURSOR_SCAN_NO 6123
CONFIDENCE standard compound; INTERNAL_ID 1335; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6107; ORIGINAL_PRECURSOR_SCAN_NO 6104
CONFIDENCE standard compound; INTERNAL_ID 1335; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 811; ORIGINAL_PRECURSOR_SCAN_NO 808
CONFIDENCE standard compound; INTERNAL_ID 1335; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 806; ORIGINAL_PRECURSOR_SCAN_NO 804
CONFIDENCE standard compound; INTERNAL_ID 1335; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 813; ORIGINAL_PRECURSOR_SCAN_NO 811
CONFIDENCE standard compound; INTERNAL_ID 1335; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 832; ORIGINAL_PRECURSOR_SCAN_NO 828
CONFIDENCE standard compound; INTERNAL_ID 1335; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 817; ORIGINAL_PRECURSOR_SCAN_NO 816
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].
Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

同义名列表

104 个代谢物同义名

(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydro-2H-pyran-3,4,5-triol; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)tetrahydropyran-3,4,5-triol; (2S,3R,4S,5S,6R)-2-(4-hydroxyphenoxy)-6-methylol-tetrahydropyran-3,4,5-triol; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-oxidanylphenoxy)oxane-3,4,5-triol; (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol; Arbutin, European Pharmacopoeia (EP) Reference Standard; alpha-Arbutin; 4-Hydroquinone-alpha-D-glucopyranoside; Arbutin, primary pharmaceutical reference standard; ICEKING Freckle Removing Whitening Facial Cleanser; 4-Hydroxyphenyl b-D-glucopyranoside, 9CI, 8CI; 5-17-07-00110 (Beilstein Handbook Reference); ISAKNOX WHITE SYMPHONY BRIGHTENING EMULSION; Sooryehan Pure-Whitening Essential Starter; ICEKING Whitening Freckle Removing Essence; ICEKING Freckle Removing Whitening Masque; beta -D-Glucopyranoside, 4-hydroxyphenyl; 4-Hydroxyphenyl-.beta.-D-glucopyranoside; beta-D-Glucopyranoside, 4-hydroxyphenyl-; P-Hydroxyphenyl beta -D-glucopyranoside; beta-D-Glucopyranoside, 4-hydroxyphenyl; I(2)-D-Glucopyranoside, 4-hydroxyphenyl; 4-Hydroxyphenyl-beta-D-glucopyranoside; p-Hydroxyphenyl beta-D-glucopyranoside; 4-Hydroxyphenyl beta-D-glucopyranoside; hydroquinone O-beta-D-glucopyranoside; HYDROQUINONE-.BETA.-D-GLUCOPYRANOSIDE; Hydroquinone-O-beta-D-glucopyranoside; b-D-Glucopyranoside, 4-hydroxyphenyl; 4-Hydroxyphenyl-beta-glucopyranoside; 4E19B706-2013-4401-A1FC-A154DADF42B4; Hydroquinone beta -D-glucopyranoside; p-Hydroxyphenyl β-D-glucopyranoside; Hydroquinone beta-D-glucopyranoside; 4-Hydroxyphenyl β-D-glucopyranoside; p-Hydroxyphenyl b-D-glucopyranoside; Hydroquinone-beta-D-glucopyranoside; Tosowoong Mens Booster Repair Skin; Hydroquinone-O-β-D-glucopyranoside; Hydroquinone-O-b-D-glucopyranoside; Hydroquinone |A-D-glucopyranoside; P-Hydroxyphenyl beta -D-glucoside; 4-Hydroxyphenyl-b-glucopyranoside; 4-Hydroxyphenyl-β-glucopyranoside; Hydroquinone β-D-glucopyranoside; p-Hydroxyphenyl beta-D-glucoside; 4-hydroxyphenyl-glucopyranoside; Hydroquinone-beta-D-glucoside; p-Hydroxyphenyl b-D-glucoside; p-Hydroxyphenyl β-D-glucoside; Arbutin, analytical standard; BJRNKVDFDLYUGJ-RMPHRYRLSA-N; Hydroquinone-D-glucoside; Arbutin (Uva, p-Arbutin); Hydroquinone-glucose; Hydroquinone glucose; Prestwick3_001026; Spectrum4_001474; ARBUTINUM [HPUS]; Spectrum5_000147; Spectrum3_001233; Spectrum2_000662; ARBUTIN [WHO-DD]; ARBUTIN [MART.]; ARBUTIN (MART.); Arbutin, >=98\\%; UNII-C5INA23HXF; ARBUTIN [HSDB]; ARBUTIN [INCI]; Tox21_111509_1; Uva,p-Arbutin; MEGxp0_001504; DivK1c_006410; BPBio1_001333; KBio2_006402; KBio3_002206; Tox21_111509; beta-Arbutin; KBio1_001354; Tox21_302428; ARBUTIN [MI]; KBio2_003834; KBio2_001266; SMP1_000028; C5INA23HXF; Arbutoside; Β-arbutin; b-Arbutin; p-Arbutin; Arbutinum; Arbutine; Ericolin; -Arbutin; Arbutyne; Arbutin; HYDRO H; Uvasol; Ursin; Ursi; 7OQ; 4-Hydroxyphenyl-β-D-glucopyranoside; Hydroquinone β-D-glucopyranoside; 4-Hydroxyphenyl hexopyranoside; Arbutin; Arbutin



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

307 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AKT1, BCL2, CASP3, CAT, MITF, NFE2L2, POMC, SIRT1, TYR, TYRP1
Golgi apparatus, trans-Golgi network membrane 1 LRBA
Peripheral membrane protein 1 GORASP1
Endosome membrane 1 TYRP1
Endoplasmic reticulum membrane 3 BCL2, HMOX1, LRBA
Nucleus 8 AKT1, BCL2, CASP3, HMOX1, MITF, MPO, NFE2L2, SIRT1
cytosol 11 AKT1, BCL2, CASP3, CAT, DCT, HMOX1, LIPE, LRBA, MITF, NFE2L2, SIRT1
centrosome 1 NFE2L2
nucleoplasm 7 AKT1, CASP3, HMOX1, MITF, MPO, NFE2L2, SIRT1
RNA polymerase II transcription regulator complex 1 NFE2L2
Cell membrane 4 AKT1, LIPE, LRBA, TNF
Cytoplasmic side 2 GORASP1, HMOX1
lamellipodium 1 AKT1
Golgi apparatus membrane 1 GORASP1
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 2 AKT1, CASP3
Golgi apparatus 3 GORASP1, LRBA, NFE2L2
Golgi membrane 2 GORASP1, INS
lysosomal membrane 3 GAA, LRBA, MITF
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 2 LIPE, NFE2L2
Lysosome 3 GAA, MPO, TYR
plasma membrane 6 AKT1, DCT, GAA, LRBA, NFE2L2, TNF
Membrane 8 AKT1, BCL2, CAT, DCT, GAA, HMOX1, LIPE, LRBA
caveola 1 LIPE
extracellular exosome 3 CAT, GAA, MPO
Lysosome membrane 3 GAA, LRBA, MITF
endoplasmic reticulum 2 BCL2, HMOX1
extracellular space 6 HMOX1, IL6, INS, MPO, POMC, TNF
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 HMOX1, TYR
mitochondrion 3 BCL2, CAT, SIRT1
protein-containing complex 4 AKT1, BCL2, CAT, MITF
intracellular membrane-bounded organelle 5 CAT, DCT, GAA, MPO, TYR
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 3 DCT, TYR, TYRP1
Secreted 4 GAA, IL6, INS, POMC
extracellular region 7 CAT, GAA, IL6, INS, MPO, POMC, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, LRBA
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 1 CAT
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 SIRT1
Melanosome membrane 3 DCT, TYR, TYRP1
cell-cell junction 1 AKT1
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
heterochromatin 1 SIRT1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Peroxisome 1 CAT
intracellular vesicle 1 TYRP1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 2 MPO, POMC
nuclear inner membrane 1 SIRT1
ciliary basal body 1 AKT1
chromatin 3 MITF, NFE2L2, SIRT1
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
tertiary granule membrane 1 GAA
Melanosome 3 DCT, TYR, TYRP1
euchromatin 1 SIRT1
myelin sheath 1 BCL2
azurophil granule 1 MPO
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
transport vesicle 1 INS
azurophil granule membrane 1 GAA
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
clathrin-coated endocytic vesicle membrane 1 TYRP1
phagocytic vesicle lumen 1 MPO
protein-DNA complex 1 NFE2L2
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Simón Miranda, Marion Koop, Andrea Angeli, Jorge Lagrèze, Mickael Malnoy, Stefan Martens. Assessment and Partial Characterization of Candidate Genes in Dihydrochalcone and Arbutin Biosynthesis in an Apple-Pear Hybrid by De Novo Transcriptome Assembly. Journal of agricultural and food chemistry. 2024 May; 72(20):11804-11819. doi: 10.1021/acs.jafc.4c01006. [PMID: 38717061]
  • Peng Shu, Yuan Wang, Lanyue Zhang. The Effect of α-Arbutin on UVB-Induced Damage and Its Underlying Mechanism. Molecules (Basel, Switzerland). 2024 Apr; 29(9):. doi: 10.3390/molecules29091921. [PMID: 38731413]
  • Oguzhan Birdal, Irmak Ferah Okkay, Ufuk Okkay, Cemil Bayram, Behzad Mokthare, Muhammed Sait Ertugrul, Ahmet Hacimuftuoglu, Emrah Aksakal, Yavuzer Koza, Mehmet Saygi, Huseyin Senocak. Protective effects of arbutin against doxorubicin-induced cardiac damage. Molecular biology reports. 2024 Apr; 51(1):532. doi: 10.1007/s11033-024-09488-4. [PMID: 38637360]
  • Mohammad Saleh Bahreini, Seyyed Farzad Pourmohammadi, Meysam Gholami, Mojtaba Habibollahi, Ardalan Pasdaran, Azadeh Hamedi, Qasem Asgari. Anti-Toxoplasma In Vitro and In Vivo Activity of Pyrus boissieriana Arbutin-Rich Fraction. Acta parasitologica. 2024 Mar; 69(1):567-573. doi: 10.1007/s11686-023-00759-x. [PMID: 38231312]
  • Boxiao Wu, Churan Li, Huan Kan, Yingjun Zhang, Xiaoping Rao, Yun Liu, Ping Zhao. Hypolipidemic and Antithrombotic Effect of 6'-O-Caffeoylarbutin from Vaccinium dunalianum Based on Zebrafish Model, Network Pharmacology, and Molecular Docking. Molecules (Basel, Switzerland). 2024 Feb; 29(4):. doi: 10.3390/molecules29040780. [PMID: 38398534]
  • Dong Xie, Wengan Fu, Tiantian Yuan, Kangjia Han, Yuxiu Lv, Qi Wang, Qian Jiang, Yingjun Zhang, Guolei Zhu, Junming Xu, Ping Zhao, Xiaoqin Yang. 6'-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020972. [PMID: 38256044]
  • Yi-Chi Chen, Yang-Yang Liu, Liqiang Chen, Dong-Mei Tang, YunLi Zhao, Xiao-Dong Luo. Antimelanogenic Effect of Isoquinoline Alkaloids from Plumula Nelumbinis. Journal of agricultural and food chemistry. 2023 Nov; 71(43):16090-16101. doi: 10.1021/acs.jafc.3c03784. [PMID: 37856847]
  • Samuel D Zarfos, Bianca J Deans, Curtis C Ho, Gregory J Jordan, Jason A Smith, Alex C Bissember. Distinctive Arbutin-Containing Markers: Chemotaxonomic Significance and Insights into the Evolution of Proteaceae Phytochemistry. Chemistry & biodiversity. 2023 Nov; 20(11):e202301112. doi: 10.1002/cbdv.202301112. [PMID: 37726205]
  • Cinzia Sanna, Ilaria Chiocchio, Manuela Mandrone, Francesca Bonvicini, Giovanna A Gentilomi, Simona Trincia, Ferruccio Poli. Metabolomic analysis and bioactivities of Arbutus unedo leaves harvested across the seasons in different natural habitats of Sardinia (Italy). BMC plant biology. 2023 Oct; 23(1):490. doi: 10.1186/s12870-023-04497-0. [PMID: 37828439]
  • Silvia Yunmam, Hae Ran Lee, Seong Min Hong, Ji-Young Kim, Tong Ho Kang, Ai Young Lee, Dae Sik Jang, Sun Yeou Kim. Aspacochioside C from Asparagus cochinchinensis attenuates eumelanin synthesis via inhibition of TRP2 expression. Scientific reports. 2023 09; 13(1):14831. doi: 10.1038/s41598-023-41248-5. [PMID: 37684311]
  • Ning An, Shubin Zhou, Xin Chen, Jia Wang, Xinxiao Sun, Xiaolin Shen, Qipeng Yuan. High-yield production of β-arbutin by identifying and eliminating byproducts formation. Applied microbiology and biotechnology. 2023 Aug; ?(?):. doi: 10.1007/s00253-023-12706-x. [PMID: 37597019]
  • Yujuan Shen, Yuanyuan Xia, Xianzhong Chen. Research progress and application of enzymatic synthesis of glycosyl compounds. Applied microbiology and biotechnology. 2023 Jul; ?(?):. doi: 10.1007/s00253-023-12652-8. [PMID: 37428188]
  • Zhengming Xu, Shuang Liu, Huining Lai, Lijun You, Zhengang Zhao. Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble 6'/6″-O-Lauryl Phenolic Glycosides with Enhanced Intestinal Permeability. Journal of agricultural and food chemistry. 2023 May; 71(20):7689-7702. doi: 10.1021/acs.jafc.3c00527. [PMID: 37167604]
  • Elif Ayazoglu Demir, Selim Demir, Ilke Onur Kazaz, Hatice Kucuk, Nihal Turkmen Alemdar, Ali Buyuk, Ahmet Mentese, Yuksel Aliyazicioglu. Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress. Tissue & cell. 2023 Mar; 82(?):102056. doi: 10.1016/j.tice.2023.102056. [PMID: 36921493]
  • H Turan Akkoyun, Ahmet Uyar, Mahire Bayramoglu Akkoyun, Aydın Şükrü Bengü, Şule Melek, Fatma Karagözoğlu, Sevinç Aydın, Suat Ekin, Sinem Aslan Erdem. The protective effect of arbutin against potassium bromate-induced oxidative damage in the rat brain. Journal of biochemical and molecular toxicology. 2023 Feb; 37(2):e23248. doi: 10.1002/jbt.23248. [PMID: 36284482]
  • Jin-Han Yang, Tong-Chen Bai, Lu-Li Shi, Bo Hou, Ran Tang, Rong-Ping Zhang, Xing-Long Chen. Antihyperlipidemic effect of Vaccinium dunalianum buds based on biological activity screening and LC-MS. Journal of ethnopharmacology. 2023 Jan; 306(?):116190. doi: 10.1016/j.jep.2023.116190. [PMID: 36693548]
  • Lutfun Nahar, Afaf Al-Groshi, Anil Kumar, Satyajit D Sarker. Arbutin: Occurrence in Plants, and Its Potential as an Anticancer Agent. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248786. [PMID: 36557918]
  • Danni Feng, Zhongxiang Fang, Pangzhen Zhang. The melanin inhibitory effect of plants and phytochemicals: A systematic review. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154449. doi: 10.1016/j.phymed.2022.154449. [PMID: 36126406]
  • Kun Zhou, Dingyan Lu, Jingrui You, Ting Liu, Jia Sun, Yuan Lu, Jie Pan, Yongjun Li, Chunhua Liu. Integrated plasma pharmacochemistry and network pharmacology to explore the mechanism of Gerberae Piloselloidis Herba in treatment of allergic asthma. Journal of ethnopharmacology. 2022 Nov; 298(?):115624. doi: 10.1016/j.jep.2022.115624. [PMID: 35970314]
  • Chunhua Liu, Jingrui You, Kun Zhou, Zipeng Gong, Jie Pan, Jia Sun, Ting Liu, Aimin Wang, Yonglin Wang, Yuan Lu, Yongjun Li. Comparative pharmacokinetics of 11 components from the active part of Gerberae Piloselloidis Herba after oral administration in control and asthmatic mice. Journal of separation science. 2022 Nov; 45(22):4023-4038. doi: 10.1002/jssc.202101010. [PMID: 36070105]
  • Shubhadeep Roychoudhury, Dipika Das, Sandipan Das, Niraj Kumar Jha, Mahadeb Pal, Adriana Kolesarova, Kavindra Kumar Kesari, Jogen C Kalita, Petr Slama. Clinical Potential of Himalayan Herb Bergenia ligulata: An Evidence-Based Study. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27207039. [PMID: 36296631]
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