Cloxacillin (BioDeep_00000002184)

 

Secondary id: BioDeep_00001867639

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

化学式: C19H18ClN3O5S (435.0656)
中文名称: 氯唑西林, 邻氯西林
谱图信息: 最多检出来源 Homo sapiens(blood) 62.96%

分子结构信息

SMILES: CC1=C(C(=NO1)C2=CC=CC=C2Cl)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)O
InChI: InChI=1S/C19H18ClN3O5S/c1-8-11(12(22-28-8)9-6-4-5-7-10(9)20)15(24)21-13-16(25)23-14(18(26)27)19(2,3)29-17(13)23/h4-7,13-14,17H,1-3H3,(H,21,24)(H,26,27)/t13-,14+,17-/m1/s1

描述信息

Cloxacillin is only found in individuals that have used or taken this drug. It is a semi-synthetic antibiotic that is a chlorinated derivative of oxacillin. [PubChem]By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, cloxacillin inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cloxacillin interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CF - Beta-lactamase resistant penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

22 个代谢物同义名

(2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; (2S,5R,6R)-6-({[3-(2-chlorophenyl)-5-methylisoxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; (2S,5R,6R)-6-[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-amido]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; 6-(3-(O-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanic acid; 6-(3-(O-Chlorophenyl)-5-methyl-4-isoxazolecarboxamido)penicillanate; (3-(O-Chlorophenyl)-5-methyl-4-isoxazolyl)penicillin; Cloxacillin, Antibiotic for Culture Media Use Only; Cloxacillin, sodium; Sodium, cloxacillin; Cloxacillin Sodium; Sodium cloxacillin; Chloroxacillin; Cloxacillinum; Cloxacilline; Cloxacilina; Cloxacillin; Syntarpen; Tegopen; Orbenin; MCIPC; Sodium cloxacillin monohydrate; Cloxacillin



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, CAT, HMGB1, SCIN, SPINT1, TYR
Peripheral membrane protein 2 CYP27A1, HMGB1
Endoplasmic reticulum membrane 3 CD4, MOXD1, OSTC
Mitochondrion membrane 1 CYP27A1
Nucleus 3 ALB, CUX1, HMGB1
cytosol 4 ALB, B2M, CAT, CUX1
centrosome 1 ALB
nucleoplasm 2 CUX1, HMGB1
Cell membrane 6 ABCB11, B2M, CD4, HMGB1, SPINT1, TNF
Early endosome membrane 1 B2M
Multi-pass membrane protein 2 ABCB11, OSTC
Golgi apparatus membrane 1 CUX1
cell cortex 1 SCIN
cell surface 5 ABCB11, B2M, HMGB1, TNF, TNR
glutamatergic synapse 1 TNR
Golgi apparatus 3 ALB, B2M, CUX1
Golgi membrane 3 ABCB11, B2M, CUX1
lysosomal membrane 1 B2M
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 1 TNF
Lysosome 1 TYR
endosome 2 ABCB11, HMGB1
plasma membrane 8 ABCB11, B2M, CD4, HMGB1, IGHE, KNG1, SPINT1, TNF
Membrane 5 ABCB11, B2M, CAT, OSTC, SPINT1
apical plasma membrane 1 ABCB11
brush border 1 SCIN
extracellular exosome 8 ABCB11, ALB, B2M, CAT, KNG1, LYZ, SCIN, SPINT1
endoplasmic reticulum 4 ALB, B2M, HMGB1, OSTC
extracellular space 12 ALB, B2M, CRP, HMGB1, IGHE, IL6, KNG1, LYZ, MOXD1, SPINT1, TNF, TNR
perinuclear region of cytoplasm 1 TYR
Schaffer collateral - CA1 synapse 1 TNR
intercellular canaliculus 1 ABCB11
mitochondrion 2 CAT, CYP27A1
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 3 CAT, CUX1, TYR
Single-pass type I membrane protein 4 CD4, IGHE, MOXD1, TYR
Secreted 6 ALB, B2M, CRP, HMGB1, IL6, SPINT1
extracellular region 12 ALB, B2M, CAT, CRP, HMGB1, IGHE, IL6, KNG1, LYZ, SPINT1, TNF, TNR
mitochondrial matrix 2 CAT, CYP27A1
Extracellular side 1 HMGB1
anchoring junction 2 ALB, SCIN
external side of plasma membrane 3 B2M, CD4, TNF
Secreted, extracellular space, extracellular matrix 1 TNR
actin cytoskeleton 1 SCIN
Melanosome membrane 1 TYR
Early endosome 1 CD4
Golgi-associated vesicle 1 TYR
recycling endosome 2 ABCB11, TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB11
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 3 CD4, TNF, TNR
Cytoplasm, cytoskeleton 1 SCIN
focal adhesion 2 B2M, CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 2 KNG1, TNR
ciliary basal body 1 ALB
chromatin 1 CUX1
IgE immunoglobulin complex 1 IGHE
Late endosome membrane 1 B2M
cell projection 1 SCIN
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 B2M
Chromosome 1 HMGB1
Cell projection, podosome 1 SCIN
podosome 1 SCIN
centriole 1 ALB
Secreted, extracellular space 1 KNG1
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
[Isoform 2]: Cell membrane 1 IGHE
Recycling endosome membrane 2 ABCB11, B2M
Melanosome 1 TYR
ficolin-1-rich granule lumen 2 CAT, HMGB1
secretory granule lumen 2 CAT, HMGB1
HFE-transferrin receptor complex 1 B2M
secretory granule membrane 1 MOXD1
endoplasmic reticulum lumen 5 ALB, B2M, CD4, IL6, KNG1
transcription repressor complex 1 HMGB1
platelet alpha granule lumen 2 ALB, KNG1
specific granule lumen 2 B2M, LYZ
tertiary granule lumen 2 B2M, LYZ
azurophil granule lumen 1 LYZ
perineuronal net 1 TNR
Single-pass type IV membrane protein 1 CUX1
ER to Golgi transport vesicle membrane 1 B2M
clathrin-coated endocytic vesicle membrane 1 CD4
endoplasmic reticulum-Golgi intermediate compartment 1 HMGB1
MHC class I peptide loading complex 1 B2M
condensed chromosome 1 HMGB1
[Isoform 3]: Cell membrane 1 IGHE
intracellular canaliculus 1 ABCB11
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
MHC class I protein complex 1 B2M
MHC class II protein complex 1 B2M
catalase complex 1 CAT
oligosaccharyltransferase complex 1 OSTC
alphav-beta3 integrin-HMGB1 complex 1 HMGB1
interleukin-6 receptor complex 1 IL6
tenascin complex 1 TNR
ciliary transition fiber 1 ALB
early endosome lumen 1 B2M
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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