Exemestane (BioDeep_00000002169)

 

Secondary id: BioDeep_00000397578

human metabolite blood metabolite


代谢物信息卡片


(1S,2R,10R,11S,15S)-2,15-dimethyl-8-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-diene-5,14-dione

化学式: C20H24O2 (296.1776)
中文名称: 依西美坦
谱图信息: 最多检出来源 Homo sapiens(blood) 8.26%

分子结构信息

SMILES: C=C1CC2C(CCC3(C)C(=O)CCC23)C2(C)C=CC(=O)C=C12
InChI: InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1

描述信息

Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to the active site of the enzyme causing its inactivation.
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02B - Hormone antagonists and related agents > L02BG - Aromatase inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D047072 - Aromatase Inhibitors
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
CONFIDENCE standard compound; EAWAG_UCHEM_ID 661
D000970 - Antineoplastic Agents

同义名列表

11 个代谢物同义名

(1S,2R,10R,11S,15S)-2,15-dimethyl-8-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadeca-3,6-diene-5,14-dione; 6-Methyleneandrosta-1,4-diene-3,17-dione; Exemestanum; ACMC-20a9mk; Exemestano; Examestane; Exemestane; Aromasine; Aromasil; Aromasin; Exemestane



数据库引用编号

32 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, AR, BCL2, BGLAP, CDK4, EGFR, ERBB2, ESR1, MTOR, PGR, PIK3C3, PIK3CA, PTGS2, TP53
Peripheral membrane protein 5 CYP1B1, ESR1, GBA1, MTOR, PTGS2
Endosome membrane 2 EGFR, ERBB2
Endoplasmic reticulum membrane 5 BCL2, CYP1B1, EGFR, MTOR, PTGS2
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 11 AKT1, AR, BCL2, CDK4, EGFR, ERBB2, ESR1, MKI67, MTOR, PGR, TP53
autophagosome 1 PIK3C3
cytosol 12 AKT1, AR, BCL2, CDK4, ERBB2, ESR1, GPT, MTOR, PGR, PIK3C3, PIK3CA, TP53
dendrite 2 BGLAP, MTOR
nuclear body 1 MKI67
phagocytic vesicle 1 MTOR
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
trans-Golgi network 1 GBA1
centrosome 1 TP53
nucleoplasm 9 AKT1, AR, CDK4, ERBB2, ESR1, MKI67, MTOR, PGR, TP53
Cell membrane 4 AKT1, EGFR, ERBB2, ESR1
Cytoplasmic side 2 ESR1, MTOR
lamellipodium 2 AKT1, PIK3CA
ruffle membrane 2 EGFR, ERBB2
Early endosome membrane 1 EGFR
Golgi apparatus membrane 1 MTOR
cell cortex 1 AKT1
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 3 AKT1, EGFR, PIK3C3
Golgi apparatus 2 ESR1, GBA1
Golgi membrane 2 EGFR, MTOR
lysosomal membrane 3 EGF, GBA1, MTOR
neuromuscular junction 1 ERBB2
postsynapse 1 AKT1
presynaptic membrane 1 ERBB2
Lysosome 2 GBA1, MTOR
endosome 2 EGFR, PIK3C3
plasma membrane 8 AKT1, AR, EGF, EGFR, ERBB2, ESR1, PGR, PIK3CA
Membrane 12 AKT1, AR, BCL2, CYP1B1, EGF, EGFR, ERBB2, ESR1, MKI67, MTOR, PIK3C3, TP53
apical plasma membrane 2 EGFR, ERBB2
basolateral plasma membrane 2 EGFR, ERBB2
caveola 1 PTGS2
extracellular exosome 3 EGF, GBA1, GPT
Lysosome membrane 2 GBA1, MTOR
Lumenal side 1 GBA1
endoplasmic reticulum 4 BCL2, GBA1, PTGS2, TP53
extracellular space 4 BGLAP, EGF, EGFR, XCL1
lysosomal lumen 1 GBA1
perinuclear region of cytoplasm 3 EGFR, ERBB2, PIK3CA
bicellular tight junction 1 CDK4
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CYP1B1, TP53
protein-containing complex 7 AKT1, AR, BCL2, EGFR, ESR1, PTGS2, TP53
intracellular membrane-bounded organelle 1 CYP1B1
Microsome membrane 3 CYP1B1, MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 EGFR, ERBB2
Secreted 1 BGLAP
extracellular region 4 BGLAP, EGF, ERBB2, XCL1
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, MTOR, PGR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 3 CDK4, ESR1, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 2 BCL2, CDK4
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CDK4, EGFR
perikaryon 1 BGLAP
cytoplasmic vesicle 1 ERBB2
microtubule cytoskeleton 1 AKT1
nucleolus 3 CDK4, MKI67, TP53
midbody 1 PIK3C3
Early endosome 1 ERBB2
cell-cell junction 1 AKT1
vesicle 2 AKT1, BGLAP
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Membrane raft 1 EGFR
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
spindle 1 AKT1
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
axoneme 1 PIK3C3
nuclear speck 1 AR
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 PIK3C3
receptor complex 2 EGFR, ERBB2
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 5 AR, CDK4, ESR1, PGR, TP53
phagocytic vesicle membrane 1 PIK3C3
Chromosome 1 MKI67
Nucleus, nucleolus 1 MKI67
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
phagophore assembly site 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
euchromatin 1 ESR1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 2 BCL2, ERBB2
basal plasma membrane 2 EGFR, ERBB2
synaptic membrane 1 EGFR
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 2 BGLAP, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
platelet alpha granule lumen 1 EGF
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
presynaptic endosome 1 PIK3C3
semaphorin receptor complex 1 ERBB2
clathrin-coated endocytic vesicle membrane 2 EGF, EGFR
[Isoform 1]: Nucleus 2 ESR1, TP53
[Isoform 1]: Cell membrane 1 ERBB2
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CDK4
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
Autolysosome 1 PIK3C3
ERBB3:ERBB2 complex 1 ERBB2
[Isoform 4]: Mitochondrion outer membrane 1 PGR
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CDK4
cyclin D2-CDK4 complex 1 CDK4
cyclin D3-CDK4 complex 1 CDK4
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

  • LiJun Yang, Yuan Xiang, SiQi Wu, Mihnea-Alexandru Găman, Kousalya Prabahar, ZhaoXia Chen. The effect of exemestane administration on the lipid profile in women: Meta-analysis of randomized controlled trials. European journal of obstetrics, gynecology, and reproductive biology. 2024 Apr; 295(?):25-33. doi: 10.1016/j.ejogrb.2024.01.021. [PMID: 38325240]
  • Md Rizwanullah, Ahmad Perwez, Meraj Alam, Shahnawaz Ahmad, Showkat Rasool Mir, Mohd Moshahid Alam Rizvi, Saima Amin. Polymer-lipid hybrid nanoparticles of exemestane for improved oral bioavailability and anti-tumor efficacy: An extensive preclinical investigation. International journal of pharmaceutics. 2023 Jun; 642(?):123136. doi: 10.1016/j.ijpharm.2023.123136. [PMID: 37311498]
  • Priya Singh, Alka, Priyanka Maurya, Raquibun Nisha, Neelu Singh, Poonam Parashar, Nidhi Mishra, Ravi Raj Pal, Shubhini A Saraf. QbD-assisted development of lipidic nanocapsules for antiestrogenic activity of exemestane in breast cancer. Journal of liposome research. 2023 Jun; 33(2):154-169. doi: 10.1080/08982104.2022.2108441. [PMID: 35930249]
  • Jiayu Wang, Li Cai, Yanqiu Song, Tao Sun, Zhongsheng Tong, Yuee Teng, Huiping Li, Quchang Ouyang, Qianjun Chen, Shude Cui, Yongmei Yin, Ning Liao, Qiang Sun, Jifeng Feng, Xiaojia Wang, Binghe Xu. Clinical efficacy of fulvestrant versus exemestane as first-line therapies for Chinese postmenopausal oestrogen-receptor positive /human epidermal growth factor receptor 2 -advanced breast cancer (FRIEND study). European journal of cancer (Oxford, England : 1990). 2023 Feb; 184(?):73-82. doi: 10.1016/j.ejca.2023.02.007. [PMID: 36905771]
  • Irina Teslenko, Christy J W Watson, Zuping Xia, Gang Chen, Philip Lazarus. Characterization of Cytosolic Glutathione S-Transferases Involved in the Metabolism of the Aromatase Inhibitor, Exemestane. Drug metabolism and disposition: the biological fate of chemicals. 2021 12; 49(12):1047-1055. doi: 10.1124/dmd.121.000635. [PMID: 34593616]
  • Norikazu Masuda, Kenji Tamura, Hiroyuki Yasojima, Akihiko Shimomura, Masataka Sawaki, Min-Jung Lee, Akira Yuno, Jane Trepel, Ryoko Kimura, Yozo Nishimura, Shigehira Saji, Hiroji Iwata. Phase 1 trial of entinostat as monotherapy and combined with exemestane in Japanese patients with hormone receptor-positive advanced breast cancer. BMC cancer. 2021 Nov; 21(1):1269. doi: 10.1186/s12885-021-08973-4. [PMID: 34819039]
  • Aliana Guerrieri-Gonzaga, Davide Serrano, Parjhitham Thomas, Katherine D Crew, Nagi B Kumar, Sara Gandini, Lana A Vornik, Jack Lee, Sara Cagnacci, Elisa Vicini, Chiara A Accornero, Mauro D'Amico, Flavio Guasone, Stefano Spinaci, Tania B Webber, Powel H Brown, Eva Szabo, Brandy Heckman-Stoddard, Bernardo Bonanni. Alternative dosing of exemestane in postmenopausal women with ER-positive breast cancer. Design and methods of a randomized presurgical trial. Contemporary clinical trials. 2021 08; 107(?):106498. doi: 10.1016/j.cct.2021.106498. [PMID: 34216815]
  • Md Rizwanullah, Ahmad Perwez, Showkat Rasool Mir, Mohd Moshahid Alam Rizvi, Saima Amin. Exemestane encapsulated polymer-lipid hybrid nanoparticles for improved efficacy against breast cancer: optimization,in vitrocharacterization and cell culture studies. Nanotechnology. 2021 Jul; 32(41):. doi: 10.1088/1361-6528/ac1098. [PMID: 34198267]
  • Giuseppe Curigliano, Miguel Martin, Komal Jhaveri, J T Beck, Giampaolo Tortora, Nicola Fazio, Michela Maur, Richard A Hubner, Harald Lahner, Valerie Donnet, Olga Ajipa, Zheng Li, Lars Blumenstein, Fabrice Andre. Alpelisib in combination with everolimus ± exemestane in solid tumours: Phase Ib randomised, open-label, multicentre study. European journal of cancer (Oxford, England : 1990). 2021 07; 151(?):49-62. doi: 10.1016/j.ejca.2021.03.042. [PMID: 33964572]
  • I Narang, A P Panthagani, M Lewis, B Chohan, A Ferguson, R Nambi. COVID-19-induced toxic epidermal necrolysis. Clinical and experimental dermatology. 2021 07; 46(5):927-929. doi: 10.1111/ced.14574. [PMID: 33511662]
  • Nicholas C Turner, Claire Swift, Lucy Kilburn, Charlotte Fribbens, Matthew Beaney, Isaac Garcia-Murillas, Aman U Budzar, John F R Robertson, William Gradishar, Martine Piccart, Gaia Schiavon, Judith M Bliss, Mitch Dowsett, Stephen R D Johnston, Stephen K Chia. ESR1 Mutations and Overall Survival on Fulvestrant versus Exemestane in Advanced Hormone Receptor-Positive Breast Cancer: A Combined Analysis of the Phase III SoFEA and EFECT Trials. Clinical cancer research : an official journal of the American Association for Cancer Research. 2020 10; 26(19):5172-5177. doi: 10.1158/1078-0432.ccr-20-0224. [PMID: 32546646]
  • Shailima Rampogu, Seong Min Kim, Minky Son, Ayoung Baek, Chanin Park, Gihwan Lee, Yumi Kim, Gon Sup Kim, Ju Hyun Kim, Keun Woo Lee. A Computational Approach with Biological Evaluation: Combinatorial Treatment of Curcumin and Exemestane Synergistically Regulates DDX3 Expression in Cancer Cell Lines. Biomolecules. 2020 06; 10(6):. doi: 10.3390/biom10060857. [PMID: 32512851]
  • Nazli Bahrami, Gregory Chang, Noriko Kanaya, Torill Sauer, Daehoon Park, Marie Loeng, Berit Gravdehaug, Shiuan Chen, Jürgen Geisler. Changes in serum estrogenic activity during neoadjuvant therapy with letrozole and exemestane. The Journal of steroid biochemistry and molecular biology. 2020 06; 200(?):105641. doi: 10.1016/j.jsbmb.2020.105641. [PMID: 32151708]
  • Dinja T Kruger, Maurice P H M Jansen, Inge R H M Konings, Wouter M Dercksen, Agnes Jager, Jamal Oulad Hadj, Stefan Sleijfer, John W M Martens, Epie Boven. High ctDNA molecule numbers relate with poor outcome in advanced ER+, HER2- postmenopausal breast cancer patients treated with everolimus and exemestane. Molecular oncology. 2020 03; 14(3):490-503. doi: 10.1002/1878-0261.12617. [PMID: 31841262]
  • Allison P Garcia, Jacob B Hatvany, Michael A Murphy, Daniel H Atchley, Bill J Gurley, Landry K Kamdem. Effect of Aromatase Inhibition (Exemestane) on Urine Concentration of Osteoprotegerin in Healthy Postmenopausal Women. Journal of clinical pharmacology. 2020 02; 60(2):209-217. doi: 10.1002/jcph.1519. [PMID: 31535401]
  • Tao He, Wenhao Yang, Xinyi Zhang, Ping Li, Dandan Yang, Yunhao Wu, Yuan Fan, Mengya Xiang, Qianqian Huang, Jing Chen, Runke Zhou, Qing Lv, Jie Chen. Comparative effectiveness of tamoxifen, toremifene, letrozole, anastrozole, and exemestane on lipid profiles in breast cancer patients: A network meta-analysis. Medicine. 2020 Jan; 99(2):e18550. doi: 10.1097/md.0000000000018550. [PMID: 31914031]
  • Mohamed Gaber, Mark Hany, Sarah Mokhtar, Maged W Helmy, Kadria A Elkodairy, Ahmed O Elzoghby. Boronic-targeted albumin-shell oily-core nanocapsules for synergistic aromatase inhibitor/herbal breast cancer therapy. Materials science & engineering. C, Materials for biological applications. 2019 Dec; 105(?):110099. doi: 10.1016/j.msec.2019.110099. [PMID: 31546395]
  • Fengqin Wei, Weiyu Chen, Xiaoti Lin. Efficacy and safety of adjuvant endocrine therapy in premenopausal patients with early-stage hormone receptor-positive breast cancer: A meta-analysis of randomized controlled trials. The breast journal. 2019 11; 25(6):1297-1299. doi: 10.1111/tbj.13465. [PMID: 31301082]
  • Archu Singh, Yub Raj Neupane, Bharti Mangla, Kanchan Kohli. Nanostructured Lipid Carriers for Oral Bioavailability Enhancement of Exemestane: Formulation Design, In Vitro, Ex Vivo, and In Vivo Studies. Journal of pharmaceutical sciences. 2019 10; 108(10):3382-3395. doi: 10.1016/j.xphs.2019.06.003. [PMID: 31201904]
  • Annelieke E C A B Willemsen, Jolien Tol, Nielka P van Erp, Marianne A Jonker, Maaike de Boer, Bob Meek, Paul C de Jong, Coline van Moorsel, Winald R Gerritsen, Jan C Grutters, Carla M L van Herpen. Prospective Study of Drug-induced Interstitial Lung Disease in Advanced Breast Cancer Patients Receiving Everolimus Plus Exemestane. Targeted oncology. 2019 08; 14(4):441-451. doi: 10.1007/s11523-019-00656-2. [PMID: 31325105]
  • Amelia McCartney, Chiara Biagioni, Gaia Schiavon, Mattias Bergqvist, Karin Mattsson, Ilenia Migliaccio, Matteo Benelli, Dario Romagnoli, Martina Bonechi, Giulia Boccalini, Marta Pestrin, Francesca Galardi, Francesca De Luca, Laura Biganzoli, Martine Piccart, William J Gradishar, Stephen Chia, Angelo Di Leo, Luca Malorni. Prognostic role of serum thymidine kinase 1 activity in patients with hormone receptor-positive metastatic breast cancer: Analysis of the randomised phase III Evaluation of Faslodex versus Exemestane Clinical Trial (EFECT). European journal of cancer (Oxford, England : 1990). 2019 06; 114(?):55-66. doi: 10.1016/j.ejca.2019.04.002. [PMID: 31059974]
  • Zefei Jiang, Wei Li, Xichun Hu, Qingyuan Zhang, Tao Sun, Shude Cui, Shusen Wang, Quchang Ouyang, Yongmei Yin, Cuizhi Geng, Zhongsheng Tong, Ying Cheng, Yueyin Pan, Yuping Sun, Hong Wang, Tao Ouyang, Kangsheng Gu, Jifeng Feng, Xiaojia Wang, Shubin Wang, Tianshu Liu, Jinghua Gao, Massimo Cristofanilli, Zhiqiang Ning, Xianping Lu. Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet. Oncology. 2019 06; 20(6):806-815. doi: 10.1016/s1470-2045(19)30164-0. [PMID: 31036468]
  • Jacqueline M Dempsey, Kelley M Kidwell, Christina L Gersch, Andrea M Pesch, Zeruesenay Desta, Anna Maria Storniolo, Vered Stearns, Todd C Skaar, Daniel F Hayes, N Lynn Henry, James M Rae, Daniel L Hertz. Effects of SLCO1B1 polymorphisms on plasma estrogen concentrations in women with breast cancer receiving aromatase inhibitors exemestane and letrozole. Pharmacogenomics. 2019 06; 20(8):571-580. doi: 10.2217/pgs-2019-0020. [PMID: 31190621]
  • M van Nuland, N Venekamp, N de Vries, K A M de Jong, H Rosing, J H Beijnen. Development and validation of an UPLC-MS/MS method for the therapeutic drug monitoring of oral anti-hormonal drugs in oncology. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Feb; 1106-1107(?):26-34. doi: 10.1016/j.jchromb.2019.01.001. [PMID: 30639947]
  • Wesley J Goedegebuure, Anita C S Hokken-Koelega. Aromatase Inhibitor as Treatment for Severely Advanced Bone Age in Congenital Adrenal Hyperplasia: A Case Report. Hormone research in paediatrics. 2019; 92(3):209-213. doi: 10.1159/000501746. [PMID: 31390647]
  • Shaman Luo, Gang Chen, Cristina I Truica, Cynthia C Baird, Zuping Xia, Philip Lazarus. Identification and Quantification of Novel Major Metabolites of the Steroidal Aromatase Inhibitor, Exemestane. Drug metabolism and disposition: the biological fate of chemicals. 2018 12; 46(12):1867-1878. doi: 10.1124/dmd.118.081166. [PMID: 30257855]
  • Wei Tian, Miaowei Wu, Yongchuan Deng. Comparison of Changes in the Lipid Profiles of Eastern Chinese Postmenopausal Women With Early-Stage Breast Cancer Treated With Different Aromatase Inhibitors: A Retrospective Study. Clinical pharmacology in drug development. 2018 11; 7(8):837-843. doi: 10.1002/cpdd.420. [PMID: 29287126]
  • Ali Nazaripour, Yadollah Yamini, Hasan Bagheri. Extraction and determination of trace amounts of three anticancer pharmaceuticals in urine by three-phase hollow fiber liquid-phase microextraction based on two immiscible organic solvents followed by high-performance liquid chromatography. Journal of separation science. 2018 Aug; 41(15):3113-3120. doi: 10.1002/jssc.201800183. [PMID: 29869408]
  • S Luo, G Chen, C Truica, C C Baird, K Leitzel, P Lazarus. Role of the UGT2B17 deletion in exemestane pharmacogenetics. The pharmacogenomics journal. 2018 04; 18(2):295-300. doi: 10.1038/tpj.2017.18. [PMID: 28534527]
  • Sophia Mastoraki, Areti Strati, Eleni Tzanikou, Maria Chimonidou, Eleni Politaki, Alexandra Voutsina, Amanda Psyrri, Vassilis Georgoulias, Evi Lianidou. ESR1 Methylation: A Liquid Biopsy-Based Epigenetic Assay for the Follow-up of Patients with Metastatic Breast Cancer Receiving Endocrine Treatment. Clinical cancer research : an official journal of the American Association for Cancer Research. 2018 03; 24(6):1500-1510. doi: 10.1158/1078-0432.ccr-17-1181. [PMID: 29284708]
  • Polly Niravath, Bingshu Chen, Judy-Anne W Chapman, Sandeep K Agarwal, Robert L Welschhans, Tim Bongartz, Krishna R Kalari, Lois E Shepherd, John Bartlett, Kathleen Pritchard, Karen Gelmon, Susan G Hilsenbeck, Mothaffar F Rimawi, C Kent Osborne, Paul E Goss, James N Ingle. Vitamin D Levels, Vitamin D Receptor Polymorphisms, and Inflammatory Cytokines in Aromatase Inhibitor-Induced Arthralgias: An Analysis of CCTG MA.27. Clinical breast cancer. 2018 02; 18(1):78-87. doi: 10.1016/j.clbc.2017.10.009. [PMID: 29128193]
  • B J Gregory, S M Chen, M A Murphy, D H Atchley, L K Kamdem. Impact of the OATP1B1 c.521T>C single nucleotide polymorphism on the pharmacokinetics of exemestane in healthy post-menopausal female volunteers. Journal of clinical pharmacy and therapeutics. 2017 Oct; 42(5):547-553. doi: 10.1111/jcpt.12569. [PMID: 28868654]
  • Brandi L Clark, Michael A Murphy, Landry K Kamdem. COX2 induction: a mechanism of endocrine breast cancer resistance?. Breast cancer research and treatment. 2017 Sep; 165(2):383-389. doi: 10.1007/s10549-017-4284-7. [PMID: 28639029]
  • Basanth Babu Eedara, Suresh Bandari. Lipid-based dispersions of exemestane for improved dissolution rate and intestinal permeability: in vitro and ex vivo characterization. Artificial cells, nanomedicine, and biotechnology. 2017 Aug; 45(5):917-927. doi: 10.1080/21691401.2016.1193023. [PMID: 27267814]
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