Probenecid (BioDeep_00000002156)

 

Secondary id: BioDeep_00000399160

human metabolite blood metabolite


代谢物信息卡片


4-((Dipropylamino)sulphonyl)benzoic acid

化学式: C13H19NO4S (285.1034734)
中文名称: 丙磺舒
谱图信息: 最多检出来源 Homo sapiens(feces) 0.21%

分子结构信息

SMILES: CCCN(CCC)S(=O)(=O)C1=CC=C(C=C1)C(=O)O
InChI: InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)

描述信息

The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. [PubChem]
CONFIDENCE standard compound; INTERNAL_ID 208; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4243; ORIGINAL_PRECURSOR_SCAN_NO 4241
CONFIDENCE standard compound; INTERNAL_ID 208; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4209; ORIGINAL_PRECURSOR_SCAN_NO 4206
CONFIDENCE standard compound; INTERNAL_ID 208; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4239; ORIGINAL_PRECURSOR_SCAN_NO 4234
ORIGINAL_PRECURSOR_SCAN_NO 4241; CONFIDENCE standard compound; INTERNAL_ID 208; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4243
CONFIDENCE standard compound; INTERNAL_ID 208; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4238; ORIGINAL_PRECURSOR_SCAN_NO 4234
CONFIDENCE standard compound; INTERNAL_ID 208; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4245; ORIGINAL_PRECURSOR_SCAN_NO 4243
CONFIDENCE standard compound; INTERNAL_ID 208; DATASET 20200303_ENTACT_RP_MIX501; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4200; ORIGINAL_PRECURSOR_SCAN_NO 4198
M - Musculo-skeletal system > M04 - Antigout preparations > M04A - Antigout preparations > M04AB - Preparations increasing uric acid excretion
D018501 - Antirheumatic Agents > D006074 - Gout Suppressants > D014528 - Uricosuric Agents
C26170 - Protective Agent > C921 - Uricosuric Agent
D010592 - Pharmaceutic Aids

同义名列表

39 个代谢物同义名

4-((Dipropylamino)sulphonyl)benzoic acid; 4-((Dipropylamino)sulfonyl)benzoic acid; 4-(N,N-Dipropylsulphamoyl)benzoesaeure; 4-(N,N-Dipropylsulfamoyl)benzoesaeure; 4-(Di-N-propylsulphamoyl)benzoesaeure; 4-((Dipropylamino)sulphonyl)benzoate; 4-(Di-N-propylsulfamoyl)benzoesaeure; 4-((Dipropylamino)sulfonyl)benzoate; p-(Dipropylsulphamoyl)benzoic acid; p-(Dipropylsulfamoyl)benzoic acid; 4-(dipropylsulfamoyl)benzoic acid; p-(Dipropylsulphamoyl)benzoate; Ophthalmic brand OF probenecid; Valdecasas brand OF probenecid; p-(Dipropylsulfamoyl)benzoate; Biokanol brand OF probenecid; Martec brand OF probenecid; Parmed brand OF probenecid; Zenith brand OF probenecid; Major brand OF probenecid; Merck brand OF probenecid; IDIS brand OF probenecid; Probenecid parmed brand; Probenecid martec brand; Probenecid zenith brand; ICN brand OF probenecid; Probenecid major brand; Probenecid weimer; Probenecid acid; Probenecidum; Probenecide; Probenecida; probenecid; Probenicid; Probecid; Pro-cid; Benecid; Benuryl; Benemid



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Aijie Zhang, Fanlong Yang, Yang Yuan, Cai Li, Xiaokui Huo, Jing Liu, Shenzhi Zhou, Wei Li, Na Zhang, Jianfeng Liu, Shiqi Dong, Huirong Fan, Ying Peng, Jiang Zheng. OAT3 Participates in Drug-Drug Interaction between Bentysrepinine and Entecavir through Interactions with M8-A Metabolite of Bentysrepinine-In Rats and Humans In Vitro. Molecules (Basel, Switzerland). 2023 Feb; 28(4):. doi: 10.3390/molecules28041995. [PMID: 36838982]
  • Xiaoxing Wang, Martin E Dowty, Ann Wouters, Svitlana Tatulych, Carol A Connell, Vu H Le, Sakambari Tripathy, Melissa T O'Gorman, Jennifer A Winton, Natalie Yin, Hernan Valdez, Bimal K Malhotra. Assessment of the Effects of Inhibition or Induction of CYP2C19 and CYP2C9 Enzymes, or Inhibition of OAT3, on the Pharmacokinetics of Abrocitinib and Its Metabolites in Healthy Individuals. European journal of drug metabolism and pharmacokinetics. 2022 May; 47(3):419-429. doi: 10.1007/s13318-021-00745-6. [PMID: 35226304]
  • Kazuhiko Ikeuchi, Kazuaki Fukushima, Masaru Tanaka, Keishiro Yajima, Akifumi Imamura. Clinical efficacy and tolerability of 1.5 g/day oral amoxicillin therapy without probenecid for the treatment of syphilis. Sexually transmitted infections. 2022 05; 98(3):173-177. doi: 10.1136/sextrans-2020-054823. [PMID: 33782148]
  • Jackelyn Murray, Harrison C Bergeron, Les P Jones, Zachary Beau Reener, David E Martin, Fred D Sancilio, Ralph A Tripp. Probenecid Inhibits Respiratory Syncytial Virus (RSV) Replication. Viruses. 2022 04; 14(5):. doi: 10.3390/v14050912. [PMID: 35632652]
  • Yan Zhou, Mengmeng Wei, Mingkang Zhang, Jianping Zhang, Fabing Tang, Xin'an Wu. Adefovir accumulation in the renal interstitium triggers mast cell degranulation and promotes renal interstitial fibrosis. Toxicology letters. 2022 Apr; 359(?):10-21. doi: 10.1016/j.toxlet.2022.01.018. [PMID: 35114312]
  • George G Zhanel, Marianna Pozdirca, Alyssa R Golden, Courtney K Lawrence, Sheryl Zelenitsky, Liam Berry, Frank Schweizer, Denice Bay, Heather Adam, Michael A Zhanel, Philippe Lagacé-Wiens, Andrew Walkty, Neal Irfan, Kurt Naber, Joseph P Lynch, James A Karlowsky. Sulopenem: An Intravenous and Oral Penem for the Treatment of Urinary Tract Infections Due to Multidrug-Resistant Bacteria. Drugs. 2022 Apr; 82(5):533-557. doi: 10.1007/s40265-022-01688-1. [PMID: 35294769]
  • Jingjing Wang, Wenjing Yuan, Qingqing Shen, Qipeng Wu, Zhenzhou Jiang, Wei Wu, Luyong Zhang, Xin Huang. The key role of organic anion transporter 3 in the drug-drug interaction between tranilast and methotrexate. Journal of biochemical and molecular toxicology. 2022 Apr; 36(4):e22983. doi: 10.1002/jbt.22983. [PMID: 35019195]
  • Ralph A Tripp, David E Martin. Repurposing Probenecid to Inhibit SARS-CoV-2, Influenza Virus, and Respiratory Syncytial Virus (RSV) Replication. Viruses. 2022 03; 14(3):. doi: 10.3390/v14030612. [PMID: 35337018]
  • Juan Güiza, Aníbal García, Javiera Arriagada, Camila Gutiérrez, Jorge González, Valeria Márquez-Miranda, Melissa Alegría-Arcos, Yorley Duarte, Maximiliano Rojas, Fernando González-Nilo, Juan C Sáez, José L Vega. Unnexins: Homologs of innexin proteins in Trypanosomatidae parasites. Journal of cellular physiology. 2022 02; 237(2):1547-1560. doi: 10.1002/jcp.30626. [PMID: 34779505]
  • Jennifer Tang, Hong Shen, Xiaofeng Zhao, Vinay K Holenarsipur, T Thanga Mariappan, Yueping Zhang, Erika Panfen, Jim Zheng, W Griffith Humphreys, Yurong Lai. Endogenous Plasma Kynurenic Acid in Human: A Newly Discovered Biomarker for Drug-Drug Interactions Involving Organic Anion Transporter 1 and 3 Inhibition. Drug metabolism and disposition: the biological fate of chemicals. 2021 12; 49(12):1063-1069. doi: 10.1124/dmd.121.000486. [PMID: 34599018]
  • Mariana Camargo, Emad Ibrahim, Teodoro C Aballa, Karina H M Cardozo, Valdemir M Carvalho, Charles M Lynne, Nancy L Brackett, Ricardo P Bertolla. Proteomic insight of seminal plasma in spinal cord injured men submitted to oral probenecid treatment for improved motility. The journal of spinal cord medicine. 2021 Nov; 44(6):966-971. doi: 10.1080/10790268.2020.1722937. [PMID: 32043922]
  • Nina Hanke, José David Gómez-Mantilla, Naoki Ishiguro, Peter Stopfer, Valerie Nock. Physiologically Based Pharmacokinetic Modeling of Rosuvastatin to Predict Transporter-Mediated Drug-Drug Interactions. Pharmaceutical research. 2021 Oct; 38(10):1645-1661. doi: 10.1007/s11095-021-03109-6. [PMID: 34664206]
  • Chad R Schultz, Matthew A Swanson, Thomas C Dowling, André S Bachmann. Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma. Cancer chemotherapy and pharmacology. 2021 10; 88(4):607-617. doi: 10.1007/s00280-021-04309-y. [PMID: 34129075]
  • Jackelyn Murray, Robert J Hogan, David E Martin, Kathy Blahunka, Fred D Sancilio, Rajiv Balyan, Mark Lovern, Richard Still, Ralph A Tripp. Probenecid inhibits SARS-CoV-2 replication in vivo and in vitro. Scientific reports. 2021 09; 11(1):18085. doi: 10.1038/s41598-021-97658-w. [PMID: 34508172]
  • Richard J Everts, Sharon J Gardiner, Mei Zhang, Ronald Begg, Stephen T Chambers, John Turnidge, Evan J Begg. Probenecid effects on cephalexin pharmacokinetics and pharmacodynamics in healthy volunteers. The Journal of infection. 2021 08; 83(2):182-189. doi: 10.1016/j.jinf.2021.05.037. [PMID: 34081957]
  • Alan Ducatman, Michael Luster, Tony Fletcher. Perfluoroalkyl substance excretion: Effects of organic anion-inhibiting and resin-binding drugs in a community setting. Environmental toxicology and pharmacology. 2021 Jul; 85(?):103650. doi: 10.1016/j.etap.2021.103650. [PMID: 33819618]
  • H Markus Weiss, Thomas Langenickel, Meredith Cain, Swarupa Kulkarni, Bharti Shah, Janardhana Vemula, Gholamreza Rahmanzadeh, Birk Poller. Clinical Investigation of Metabolic and Renal Clearance Pathways Contributing to the Elimination of Fevipiprant Using Probenecid as Perpetrator. Drug metabolism and disposition: the biological fate of chemicals. 2021 05; 49(5):389-394. doi: 10.1124/dmd.120.000273. [PMID: 33632715]
  • Azusa Futatsugi, Yusuke Masuo, Yukio Kato. Effects of Probenecid on Hepatic and Renal Disposition of Hexadecanedioate, an Endogenous Substrate of Organic Anion Transporting Polypeptide 1B in Rats. Journal of pharmaceutical sciences. 2021 05; 110(5):2274-2284. doi: 10.1016/j.xphs.2021.02.011. [PMID: 33607188]
  • Amais Ahmad, Kayode Ogungbenro, Annett Kunze, Frank Jacobs, Jan Snoeys, Amin Rostami-Hodjegan, Aleksandra Galetin. Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters. CPT: pharmacometrics & systems pharmacology. 2021 05; 10(5):467-477. doi: 10.1002/psp4.12610. [PMID: 33704919]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Sabrina T Wiebe, Thomas Giessmann, Kathrin Hohl, Sven Schmidt-Gerets, Edith Hauel, Alen Jambrecina, Kerstin Bader, Naoki Ishiguro, Mitchell E Taub, Ashish Sharma, Thomas Ebner, Gerd Mikus, Martin F Fromm, Fabian Müller, Peter Stopfer. Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine. Clinical pharmacokinetics. 2020 12; 59(12):1627-1639. doi: 10.1007/s40262-020-00907-w. [PMID: 32504272]
  • Hannah Britz, Nina Hanke, Mitchell E Taub, Ting Wang, Bhagwat Prasad, Éric Fernandez, Peter Stopfer, Valerie Nock, Thorsten Lehr. Physiologically Based Pharmacokinetic Models of Probenecid and Furosemide to Predict Transporter Mediated Drug-Drug Interactions. Pharmaceutical research. 2020 Nov; 37(12):250. doi: 10.1007/s11095-020-02964-z. [PMID: 33237382]
  • Yueping Zhang, Vinay K Holenarsipur, Hamza Kandoussi, Jianing Zeng, T Thanga Mariappan, Michael Sinz, Hong Shen. Detection of Weak Organic Anion-Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans. Drug metabolism and disposition: the biological fate of chemicals. 2020 10; 48(10):841-848. doi: 10.1124/dmd.120.000076. [PMID: 32723847]
  • Sil-Ling Pruis, Yunjoo Karris Jeon, Fiona Pearce, Bernard Yu-Hor Thong, Mohamed Ismail Abdul Aziz. Cost-effectiveness of sequential urate lowering therapies for the management of gout in Singapore. Journal of medical economics. 2020 Aug; 23(8):838-847. doi: 10.1080/13696998.2020.1757456. [PMID: 32301360]
  • Shelia B Dunaway, Clare L Maxwell, Lauren C Tantalo, Sharon K Sahi, Christina M Marra. Neurosyphilis Treatment Outcomes After Intravenous Penicillin G Versus Intramuscular Procaine Penicillin Plus Oral Probenecid. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 07; 71(2):267-273. doi: 10.1093/cid/ciz795. [PMID: 31504293]
  • Cheryl K T Chua, Peter P Cheung, Amelia Santosa, Anita Y N Lim, Gim Gee Teng. Burden and management of gout in a multi-ethnic Asian cohort. Rheumatology international. 2020 Jul; 40(7):1029-1035. doi: 10.1007/s00296-019-04475-6. [PMID: 31758246]
  • Angela Ostuni, Monica Carmosino, Rocchina Miglionico, Vittorio Abruzzese, Fabio Martinelli, Daniela Russo, Ilaria Laurenzana, Agata Petillo, Faustino Bisaccia. Inhibition of ABCC6 Transporter Modifies Cytoskeleton and Reduces Motility of HepG2 Cells via Purinergic Pathway. Cells. 2020 06; 9(6):. doi: 10.3390/cells9061410. [PMID: 32517079]
  • Stephanie N Liu, Brandon T Gufford, Jessica Bo Li Lu, Lane R Bushman, Peter L Anderson, Richard F Bergstrom, Zeruesenay Desta, Samir K Gupta. Inhibitory Effects of Probenecid on Pharmacokinetics of Tenofovir Disoproxil Fumarate and Emtricitabine for On-Demand HIV Preexposure Prophylaxis. Clinical pharmacology and therapeutics. 2020 05; 107(5):1200-1208. doi: 10.1002/cpt.1714. [PMID: 31675437]
  • Peter Hemmersbach. The Probenecid-story - A success in the fight against doping through out-of-competition testing. Drug testing and analysis. 2020 May; 12(5):589-594. doi: 10.1002/dta.2727. [PMID: 31797550]
  • Im-Sook Song, Hyeon-Uk Jeong, Min-Koo Choi, Mihwa Kwon, Yongho Shin, Jeong Han Kim, Hye-Suk Lee. Interactions between cyazofamid and human drug transporters. Journal of biochemical and molecular toxicology. 2020 Apr; 34(4):e22459. doi: 10.1002/jbt.22459. [PMID: 32003934]
  • Fan Hong, Aijuan Zheng, Pengfei Xu, Jialin Wang, Tingting Xue, Shu Dai, Shijia Pan, Yuan Guo, Xinlu Xie, Letong Li, Xiaoxiao Qiao, Guohua Liu, Yonggong Zhai. High-Protein Diet Induces Hyperuricemia in a New Animal Model for Studying Human Gout. International journal of molecular sciences. 2020 Mar; 21(6):. doi: 10.3390/ijms21062147. [PMID: 32245084]
  • Dandan Zhou, Yunting Xu, Yedong Wang, Jiajun Li, Chunshan Gui, Hongjian Zhang. Interaction of Organic Anion Transporter 3-Mediated Uptake of Steviol Acyl Glucuronide, a Major Metabolite of Rebaudioside A, with Selected Drugs. Journal of agricultural and food chemistry. 2020 Feb; 68(6):1579-1587. doi: 10.1021/acs.jafc.9b05808. [PMID: 31760750]
  • Stephanie N Liu, Zeruesenay Desta, Brandon T Gufford. Probenecid-Boosted Tenofovir: A Physiologically-Based Pharmacokinetic Model-Informed Strategy for On-Demand HIV Preexposure Prophylaxis. CPT: pharmacometrics & systems pharmacology. 2020 01; 9(1):40-47. doi: 10.1002/psp4.12481. [PMID: 31749296]
  • Xiao-Ying Liao, Qiang-Qiang Deng, Li Han, Zhi-Tao Wu, Zhao-Liang Peng, Yuan Xie, Guang-Ji Wang, Ji-Ye Aa, Guo-Yu Pan. Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2. Acta pharmacologica Sinica. 2020 Jan; 41(1):129-137. doi: 10.1038/s41401-019-0283-z. [PMID: 31341258]
  • Richard J Everts, Ronald Begg, Sharon J Gardiner, Mei Zhang, John Turnidge, Stephen T Chambers, Evan J Begg. Probenecid and food effects on flucloxacillin pharmacokinetics and pharmacodynamics in healthy volunteers. The Journal of infection. 2020 01; 80(1):42-53. doi: 10.1016/j.jinf.2019.09.004. [PMID: 31521742]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Alexander F Flynn, M Gordon Joyce, Rebekah T Taylor, Sasisekhar Bennuru, Alyssa R Lindrose, Spencer L Sterling, C Paul Morris, Thomas B Nutman, Edward Mitre. Intestinal UDP-glucuronosyltransferase as a potential target for the treatment and prevention of lymphatic filariasis. PLoS neglected tropical diseases. 2019 09; 13(9):e0007687. doi: 10.1371/journal.pntd.0007687. [PMID: 31513587]
  • Susan Burks, James Raymick, Bonnie Robinson, Joseph Hanig, Sumit Sarkar. Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson's disease mouse model: Endothelial and microglial effects. Neuroscience letters. 2019 06; 703(?):86-95. doi: 10.1016/j.neulet.2019.03.015. [PMID: 30890473]
  • Michael Chen-Xu, Chio Yokose, Sharan K Rai, Michael H Pillinger, Hyon K Choi. Contemporary Prevalence of Gout and Hyperuricemia in the United States and Decadal Trends: The National Health and Nutrition Examination Survey, 2007-2016. Arthritis & rheumatology (Hoboken, N.J.). 2019 06; 71(6):991-999. doi: 10.1002/art.40807. [PMID: 30618180]
  • Xiaoying Han, Jing Yang, Dong Li, Zewei Guo. Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells. Oncology research. 2019 May; 27(5):533-540. doi: 10.3727/096504018x15199489058224. [PMID: 29523220]
  • Xue Li, Yilin Qiao, Xue Wang, Ruicong Ma, Tianxiang Li, Youcai Zhang, Robert P Borris. Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3. Journal of natural products. 2019 04; 82(4):832-839. doi: 10.1021/acs.jnatprod.8b00888. [PMID: 30892891]
  • Xue Xue, Weiwei Zhang, Jifeng Zhu, Xiaojun Chen, Sha Zhou, Zhipeng Xu, Gang Hu, Chuan Su. Aquaporin-4 deficiency reduces TGF-β1 in mouse midbrains and exacerbates pathology in experimental Parkinson's disease. Journal of cellular and molecular medicine. 2019 04; 23(4):2568-2582. doi: 10.1111/jcmm.14147. [PMID: 30680924]
  • Xinrui Li, Jing Liu, Liang Ma, Ping Fu. Pharmacological urate-lowering approaches in chronic kidney disease. European journal of medicinal chemistry. 2019 Mar; 166(?):186-196. doi: 10.1016/j.ejmech.2019.01.043. [PMID: 30769179]
  • Bahar Matin, Ahmad A Sherbini, Novera Alam, Jerold S Harmatz, David J Greenblatt. Resveratrol glucuronidation in vitro: potential implications of inhibition by probenecid. The Journal of pharmacy and pharmacology. 2019 Mar; 71(3):371-378. doi: 10.1111/jphp.13037. [PMID: 30417385]
  • Yilin Qiao, Xueling Liu, Xue Li, Xue Wang, Caiyu Li, Manana Khutsishvili, Valida Alizade, Daniel Atha, Youcai Zhang, Robert P Borris. Biflavonoids from Juniperus oblonga inhibit organic anion transporter 3. Biochemical and biophysical research communications. 2019 02; 509(4):931-936. doi: 10.1016/j.bbrc.2019.01.039. [PMID: 30648554]
  • Brendan J Tunstall, Irene Lorrai, Sam A McConnell, Katrina L Gazo, Lia J Zallar, Giordano de Guglielmo, Ivy Hoang, Carolina L Haass-Koffler, Vez Repunte-Canonigo, George F Koob, Leandro F Vendruscolo, Pietro Paolo Sanna. Probenecid Reduces Alcohol Drinking in Rodents. Is Pannexin1 a Novel Therapeutic Target for Alcohol Use Disorder?. Alcohol and alcoholism (Oxford, Oxfordshire). 2019 Jan; 54(5):497-502. doi: 10.1093/alcalc/agz054. [PMID: 31535696]
  • Philip C Robinson. Gout - An update of aetiology, genetics, co-morbidities and management. Maturitas. 2018 Dec; 118(?):67-73. doi: 10.1016/j.maturitas.2018.10.012. [PMID: 30415758]
  • Huaiwu He, Dawei Liu, Yun Long, Xiaoting Wang, Bo Yao. The Pannexin-1 Channel Inhibitor Probenecid Attenuates Skeletal Muscle Cellular Energy Crisis and Histopathological Injury in a Rabbit Endotoxemia Model. Inflammation. 2018 Dec; 41(6):2030-2040. doi: 10.1007/s10753-018-0846-z. [PMID: 30014232]
  • Mei Zhang, Grant A Moore, Paul K L Chin, Richard Everts, Evan J Begg. Simultaneous Determination of Cefalexin, Cefazolin, Flucloxacillin, and Probenecid by Liquid Chromatography-Tandem Mass Spectrometry for Total and Unbound Concentrations in Human Plasma. Therapeutic drug monitoring. 2018 12; 40(6):682-692. doi: 10.1097/ftd.0000000000000555. [PMID: 30015652]
  • Jin Gyu Choi, Eugene Huh, In Gyoung Ju, Namkwon Kim, Jason Yun, Myung Sook Oh. 1-Methyl-4-phenyl-1,2,3,6 tetrahydropyridine/probenecid impairs intestinal motility and olfaction in the early stages of Parkinson's disease in mice. Journal of the neurological sciences. 2018 09; 392(?):77-82. doi: 10.1016/j.jns.2018.07.011. [PMID: 30031172]
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  • Tom T G Nieskens, Janny G P Peters, Dina Dabaghie, Daphne Korte, Katja Jansen, Alexander H Van Asbeck, Neslihan N Tavraz, Thomas Friedrich, Frans G M Russel, Rosalinde Masereeuw, Martijn J Wilmer. Expression of Organic Anion Transporter 1 or 3 in Human Kidney Proximal Tubule Cells Reduces Cisplatin Sensitivity. Drug metabolism and disposition: the biological fate of chemicals. 2018 05; 46(5):592-599. doi: 10.1124/dmd.117.079384. [PMID: 29514829]
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