OMETHOATE (BioDeep_00000002113)

   


代谢物信息卡片


2-dimethoxyphosphorylsulfanyl-N-methylacetamide

化学式: C5H12NO4PS (213.02246419999997)
中文名称: 氧化乐果
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CNC(=O)CSP(=O)(OC)OC
InChI: InChI=1S/C5H12NO4PS/c1-6-5(7)4-12-11(8,9-2)10-3/h4H2,1-3H3,(H,6,7)

描述信息

C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
CONFIDENCE standard compound; INTERNAL_ID 3027

同义名列表

2 个代谢物同义名

OMETHOATE; 2-dimethoxyphosphorylsulfanyl-N-methylacetamide



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ratnamma Pasar, Pallavi Ms, Harischandra Naik R, Devaraj M, Nandini P, Bheemanna M, Badariprasad P R, Paramasivam M. Simultaneous determination of dimethoate and its metabolite omethoate in curry leaf using LC-MS/MS and risk assessment. Journal of separation science. 2022 Jun; 45(11):1831-1838. doi: 10.1002/jssc.202100696. [PMID: 35315569]
  • Xiaoshan Zhou, Xinling Li, Wan Wei, Xiaoran Duan, Hui Zhang, Mingcui Ding, Wu Yao, Qi Wang, Wei Wang, Yongli Yang. Association between genetic polymorphisms of telomere pathway genes and hydrogen peroxide level in omethoate exposure workers. Environmental toxicology and pharmacology. 2021 Feb; 82(?):103541. doi: 10.1016/j.etap.2020.103541. [PMID: 33161111]
  • Tuanwei Wang, Hui Zhang, Lei Li, Wenjuan Zhang, Qi Wang, Wei Wang. Plasma cholinesterase activity is influenced by interactive effect between omethoate exposure and CYP2E1 polymorphisms. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2021; 56(5):477-482. doi: 10.1080/03601234.2021.1911517. [PMID: 33872129]
  • Andreas Kranawetvogl, Markus Siegert, Florian Eyer, Horst Thiermann, Harald John. Verification of organophosphorus pesticide poisoning: Detection of phosphorylated tyrosines and a cysteine-proline disulfide-adduct from human serum albumin after intoxication with dimethoate/omethoate. Toxicology letters. 2018 Dec; 299(?):11-20. doi: 10.1016/j.toxlet.2018.08.013. [PMID: 30165092]
  • Mingcui Ding, Yongli Yang, Xiaoran Duan, Sihua Wang, Xiaolei Feng, Tuanwei Wang, Pengpeng Wang, Suxiang Liu, Lei Li, Junling Liu, Lixia Tang, Xinhua Niu, Yuhong Zhang, Guoyu Li, Wu Yao, Liuxin Cui, Wei Wang. Association of genetic polymorphisms of telomere binding proteins with cholinesterase activity in omethoate-exposed workers. Ecotoxicology and environmental safety. 2018 10; 161(?):563-568. doi: 10.1016/j.ecoenv.2018.06.036. [PMID: 29929132]
  • Kejun Yang, Yifei Zhang, Lianhua Zhu, Zuotong Li, Benliang Deng. Omethoate treatment mitigates high salt stress inhibited maize seed germination. Pesticide biochemistry and physiology. 2018 Jan; 144(?):79-82. doi: 10.1016/j.pestbp.2017.12.001. [PMID: 29463412]
  • Xiang Wei, Yiou Pan, Xuecheng Xin, Chao Zheng, Xiwu Gao, Jinghui Xi, Qingli Shang. Cross-resistance pattern and basis of resistance in a thiamethoxam-resistant strain of Aphis gossypii Glover. Pesticide biochemistry and physiology. 2017 May; 138(?):91-96. doi: 10.1016/j.pestbp.2017.03.007. [PMID: 28456311]
  • G Albendín, J M Arellano, M P Mánuel-Vez, C Sarasquete, M I Arufe. Characterization and in vitro sensitivity of cholinesterases of gilthead seabream (Sparus aurata) to organophosphate pesticides. Fish physiology and biochemistry. 2017 Apr; 43(2):455-464. doi: 10.1007/s10695-016-0299-y. [PMID: 27714546]
  • You-Hui Gong, Xin-Rui Yu, Qing-Li Shang, Xue-Yan Shi, Xi-Wu Gao. Oral delivery mediated RNA interference of a carboxylesterase gene results in reduced resistance to organophosphorus insecticides in the cotton Aphid, Aphis gossypii Glover. PloS one. 2014; 9(8):e102823. doi: 10.1371/journal.pone.0102823. [PMID: 25140535]
  • Qin Zhao, Qian Lu, Qiong-Wei Yu, Yu-Qi Feng. Dispersive microextraction based on "magnetic water" coupled to gas chromatography/mass spectrometry for the fast determination of organophosphorus pesticides in cold-pressed vegetable oils. Journal of agricultural and food chemistry. 2013 Jun; 61(22):5397-403. doi: 10.1021/jf400870m. [PMID: 23687955]
  • Idriss Bakas, Najwa Ben Oujji, Ewa Moczko, Georges Istamboulie, Sergey Piletsky, Elena Piletska, Elhabib Ait-Addi, Ihya Ait-Ichou, Thierry Noguer, Régis Rouillon. Computational and experimental investigation of molecular imprinted polymers for selective extraction of dimethoate and its metabolite omethoate from olive oil. Journal of chromatography. A. 2013 Jan; 1274(?):13-8. doi: 10.1016/j.chroma.2012.11.061. [PMID: 23290360]
  • Jia Zhou, Lei Zhang, Yuwei Chang, Xin Lu, Zhen Zhu, Guowang Xu. Alteration of leaf metabolism in Bt-transgenic rice (Oryza sativa L.) and its wild type under insecticide stress. Journal of proteome research. 2012 Aug; 11(8):4351-60. doi: 10.1021/pr300495x. [PMID: 22768924]
  • Musa Isnas, Esref Yegin, Ismail Celik. Effects of omethoate on certain oxidative biomarkers in various tissues of frogs (Rana ridibunda) at acute exposure. Toxicology and industrial health. 2012 Feb; 28(1):27-34. doi: 10.1177/0748233711403191. [PMID: 22025503]
  • Najwa Ben Oujji, Idriss Bakas, Georges Istamboulié, Ihya Ait-Ichou, Elhabib Ait-Addi, Régis Rouillon, Thierry Noguer. Acetylcholinesterase immobilized on magnetic beads for pesticides detection: application to olive oil analysis. Sensors (Basel, Switzerland). 2012; 12(6):7893-904. doi: 10.3390/s120607893. [PMID: 22969377]
  • Sudheera S Jayasinghe, Kithsiri D Pathirana. Autonomic function following acute organophosphorus poisoning: a cohort study. PloS one. 2012; 7(5):e37987. doi: 10.1371/journal.pone.0037987. [PMID: 22655091]
  • Nayana K Jayatilaka, M Angela Montesano, Ralph D Whitehead, Sara J Schloth, Larry L Needham, Dana Boyd Barr. High-throughput sample preparation for the quantitation of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea, and propylenethiourea in human urine using 96-well-plate automated extraction and high-performance liquid chromatography-tandem mass spectrometry. Archives of environmental contamination and toxicology. 2011 Jul; 61(1):59-67. doi: 10.1007/s00244-010-9593-3. [PMID: 20878153]
  • Yiou Pan, Qingli Shang, Kui Fang, Jing Zhang, Jinghui Xi. Down-regulated transcriptional level of Ace1 combined with mutations in Ace1 and Ace2 of Aphis gossypii are related with omethoate resistance. Chemico-biological interactions. 2010 Dec; 188(3):553-7. doi: 10.1016/j.cbi.2010.07.022. [PMID: 20692243]
  • Lina Lu, Xiuli Wang, Liwei Lang, Fenghua Fu. Protective effect of reduced glutathione on the liver injury induced by acute omethoate poisoning. Environmental toxicology and pharmacology. 2010 Nov; 30(3):279-83. doi: 10.1016/j.etap.2010.08.001. [PMID: 21787660]
  • Rosemary Castorina, Asa Bradman, Laura Fenster, Dana Boyd Barr, Roberto Bravo, Michelle G Vedar, Martha E Harnly, Thomas E McKone, Ellen A Eisen, Brenda Eskenazi. Comparison of current-use pesticide and other toxicant urinary metabolite levels among pregnant women in the CHAMACOS cohort and NHANES. Environmental health perspectives. 2010 Jun; 118(6):856-63. doi: 10.1289/ehp.0901568. [PMID: 20129873]
  • Xian-Li Yang, Min-Dong Bai, Feng Han. [Rapid elimination of surface organophosphorous pollutants using hydroxyl radical]. Huan jing ke xue= Huanjing kexue. 2010 Jun; 31(6):1670-4. doi: NULL. [PMID: 20698288]
  • Harald John, Michael Eddleston, R Eddie Clutton, Franz Worek, Horst Thiermann. Simultaneous quantification of the organophosphorus pesticides dimethoate and omethoate in porcine plasma and urine by LC-ESI-MS/MS and flow-injection-ESI-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 May; 878(17-18):1234-45. doi: 10.1016/j.jchromb.2010.01.003. [PMID: 20106727]
  • W Sun, Y Jin, L He, W-C Lu, M Li. Suitable reference gene selection for different strains and developmental stages of the carmine spider mite, Tetranychus cinnabarinus, using quantitative real-time PCR. Journal of insect science (Online). 2010; 10(?):208. doi: 10.1673/031.010.20801. [PMID: 21265619]
  • Michael Eddleston, David Gunnell, Ludwig von Meyer, Peter Eyer. Relationship between blood alcohol concentration on admission and outcome in dimethoate organophosphorus self-poisoning. British journal of clinical pharmacology. 2009 Dec; 68(6):916-9. doi: 10.1111/j.1365-2125.2009.03533.x. [PMID: 20002086]
  • Wei Zhao, Pei-Yu Ge, Jing-Juan Xu, Hong-Yuan Chen. Selective detection of hypertoxic organophosphates pesticides via PDMS composite based acetylcholinesterase-inhibition biosensor. Environmental science & technology. 2009 Sep; 43(17):6724-9. doi: 10.1021/es900841n. [PMID: 19764241]
  • Yanhong Bai, Jierong Chen, Hui Mu, Chunhong Zhang, Baoping Li. Reduction of dichlorvos and omethoate residues by O2 plasma treatment. Journal of agricultural and food chemistry. 2009 Jul; 57(14):6238-45. doi: 10.1021/jf900995d. [PMID: 19534530]
  • En-shun Jiang, Ming Xue, Yu-qing Liu, Yu-feng Wang. [Toxicity of Vitex negundo extract to aphids and its co-toxicity with imidacloprid]. Ying yong sheng tai xue bao = The journal of applied ecology. 2009 Mar; 20(3):686-90. doi: ". [PMID: 19637611]
  • Wei-Juan Li, Zhi-Kui Gao, Mei Wang, Yan-Po Cao, Zhan-Jun Xue. [Toxicological effects of omethoate on leaf photosystem II of cole]. Ying yong sheng tai xue bao = The journal of applied ecology. 2008 Oct; 19(10):2317-21. doi: . [PMID: 19123372]
  • F A Tarbah, A M Shaheen, F A Benomran, A I Hassan, Th Daldrup. Distribution of dimethoate in the body after a fatal organophosphate intoxication. Forensic science international. 2007 Aug; 170(2-3):129-32. doi: 10.1016/j.forsciint.2007.04.232. [PMID: 17643882]
  • M Angela Montesano, Anders O Olsson, Peter Kuklenyik, Larry L Needham, A S A Bradman, Dana B Barr. Method for determination of acephate, methamidophos, omethoate, dimethoate, ethylenethiourea and propylenethiourea in human urine using high-performance liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry. Journal of exposure science & environmental epidemiology. 2007 Jul; 17(4):321-30. doi: 10.1038/sj.jes.7500550. [PMID: 17440487]
  • Pei Liang, Jian-Zhou Cui, Xiu-Qing Yang, Xi-Wu Gao. Effects of host plants on insecticide susceptibility and carboxylesterase activity in Bemisia tabaci biotype B and greenhouse whitefly, Trialeurodes vaporariorum. Pest management science. 2007 Apr; 63(4):365-71. doi: 10.1002/ps.1346. [PMID: 17323411]
  • Mao-hua Chen, Zhao-jun Han, Xian-feng Qiao, Ming-jing Qu. Mutations in acetylcholinesterase genes of Rhopalosiphum padi resistant to organophosphate and carbamate insecticides. Genome. 2007 Feb; 50(2):172-9. doi: 10.1139/g07-021. [PMID: 17546082]
  • J Castillo-Cadena, L E Tenorio-Vieyra, A I Quintana-Carabia, M M García-Fabila, E Ramírez-San Juan, E Madrigal-Bujaidar. Determination of DNA damage in floriculturists exposed to mixtures of pesticides. Journal of biomedicine & biotechnology. 2006; 2006(2):97896. doi: 10.1155/jbb/2006/97896. [PMID: 16883059]
  • C Aprea, L Centi, S Santini, L Lunghini, B Banchi, G Sciarra. Exposure to omethoate during stapling of ornamental plants in intensive cultivation tunnels: influence of environmental conditions on absorption of the pesticide. Archives of environmental contamination and toxicology. 2005 Nov; 49(4):577-88. doi: 10.1007/s00244-005-8025-2. [PMID: 16132410]
  • M Pavlic, A Haidekker, P Grubwieser, W Rabl. Fatal intoxication with omethoate. International journal of legal medicine. 2002 Aug; 116(4):238-41. doi: 10.1007/s00414-002-0299-6. [PMID: 12185494]
  • Z L Zhang, H S Hong, J L Zhou, G Yu. Occurrence and behaviour of organophosphorus insecticides in the River Wuchuan, southeast China. Journal of environmental monitoring : JEM. 2002 Aug; 4(4):498-504. doi: 10.1039/b203852h. [PMID: 12195990]
  • Shuiping Cheng, Zeljka Vidakovic-Cifrek, Wolfgang Grosse, Friedhelm Karrenbrock. Xenobiotics removal from polluted water by a multifunctional constructed wetland. Chemosphere. 2002 Jul; 48(4):415-8. doi: 10.1016/s0045-6535(02)00097-8. [PMID: 12152743]
  • C Aprea, G Sciarra, L Lunghini, L Centi, F Ceccarelli. Evaluation of respiratory and cutaneous doses and urinary excretion of alkylphosphates by workers in greenhouses treated with omethoate, fenitrothion, and tolclofos-methyl. AIHAJ : a journal for the science of occupational and environmental health and safety. 2001 Jan; 62(1):87-95. doi: 10.1080/15298660108984614. [PMID: 11258873]
  • Z Lu, X Yu, J Chen, X Zheng, J Tang. [Tolerance of various geographic populations of brown planthopper to adverse environmental stresses]. Ying yong sheng tai xue bao = The journal of applied ecology. 2000 Oct; 11(5):745-8. doi: ". [PMID: 11767535]
  • C Aprea, G Sciarra, P Sartorelli, F Ceccarelli, M Maiorano, G Savelli. [Evaluation of omethoate and fenitrothion absorption in greenhouse workers using protective equipment in confined areas]. La Medicina del lavoro. 1994 May; 85(3):242-8. doi: NULL. [PMID: 7935147]
  • L López-Carillo, M López-Cervantes. Effect of exposure to organophosphate pesticides on serum cholinesterase levels. Archives of environmental health. 1993 Sep; 48(5):359-63. doi: 10.1080/00039896.1993.9936726. [PMID: 8215602]