Monocrotaline (BioDeep_00000002079)

 

Secondary id: BioDeep_00000229961

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


5,6-dihydroxy-4,5,6-trimethyl-2,8-dioxa-13-azatricyclo[8.5.1.0¹³,¹⁶]hexadec-10-ene-3,7-dione

化学式: C16H23NO6 (325.1525)
中文名称: 野百合碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 25.69%

分子结构信息

SMILES: CC1C(=O)OC2CCN3C2C(=CC3)COC(=O)C(C1(C)O)(C)O
InChI: InChI=1S/C16H23NO6/c1-9-13(18)23-11-5-7-17-6-4-10(12(11)17)8-22-14(19)16(3,21)15(9,2)20/h4,9,11-12,20-21H,5-8H2,1-3H3

描述信息

Hepatotoxin. Causative agent of much seneciosis, e.g. accidental poisoning by S. by weed residues in bread, and characterised by venoocculosive disease
Hepatotoxin. Causative agent of much seneciosis, e.g. accidental poisoning by S. by weed residues in bread, and characterised by venoocculosive diseas
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 2249
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 131
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 121
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 151
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 141
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 111
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 161
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 171
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 101
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 μM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].
Monocrotaline is an 11-membered macrocyclic pyrrolizidine alkaloid. Monocrotaline inhibits OCT-1 and OCT-2 with IC50s of 36.8 μM and 1.8 mM, respectively. Monocrotaline has antitumor activity and is cytotoxic to hepatocellular carcinoma cells. Monocrotaline is used to induce a model of pulmonary hypertension in rodents. [2][6][8].

同义名列表

7 个代谢物同义名

5,6-dihydroxy-4,5,6-trimethyl-2,8-dioxa-13-azatricyclo[8.5.1.0¹³,¹⁶]hexadec-10-ene-3,7-dione; 14,19-dihydro-12,13-Dihydroxy-20-norcrotalanan-11,15-dione, 9ci; Monocrotaline; Monocrotalin; Crotaline; Monocrotaline; Monocrotaline



数据库引用编号

83 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

101 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ANG, BCL2, CASP3, CCND1, GJA1, MAPK1, MAPK14, PPARG, STAT3, VEGFA
Endoplasmic reticulum membrane 2 BCL2, GJA1
Nucleus 12 ANG, BCL2, CASP3, CCND1, GABPA, GJA1, MAPK1, MAPK14, PCNA, PPARG, STAT3, VEGFA
cytosol 10 ANG, BCL2, CASP3, CCND1, GJA1, GPT, MAPK1, MAPK14, PPARG, STAT3
dendrite 1 BMPR2
nuclear body 1 PCNA
centrosome 3 CCND1, MAPK1, PCNA
nucleoplasm 10 BMPR2, CASP3, CCND1, GABPA, GJA1, MAPK1, MAPK14, PCNA, PPARG, STAT3
RNA polymerase II transcription regulator complex 2 PPARG, STAT3
Cell membrane 5 BMPR2, EDNRB, GJA1, PECAM1, TNF
Multi-pass membrane protein 2 EDNRB, GJA1
Synapse 1 MAPK1
cell junction 2 GJA1, PECAM1
cell surface 3 BMPR2, TNF, VEGFA
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 4 CCN2, GJA1, MAPK1, VEGFA
Golgi membrane 1 GJA1
growth cone 1 ANG
neuronal cell body 4 ANG, BMPR2, CASP3, TNF
plasma membrane 9 BMPR2, CCN2, EDNRB, GJA1, MAPK1, PECAM1, REN, STAT3, TNF
Membrane 3 BCL2, REN, VEGFA
apical plasma membrane 2 BMPR2, GJA1
axon 1 BMPR2
caveola 2 BMPR2, MAPK1
extracellular exosome 3 GPT, PCNA, PECAM1
endoplasmic reticulum 3 BCL2, GJA1, VEGFA
extracellular space 8 ANG, BMPR2, CCN2, IL6, PECAM1, REN, TNF, VEGFA
perinuclear region of cytoplasm 1 PPARG
adherens junction 2 BMPR2, VEGFA
bicellular tight junction 1 CCND1
gap junction 1 GJA1
intercalated disc 1 GJA1
mitochondrion 4 BCL2, GJA1, MAPK1, MAPK14
protein-containing complex 2 BCL2, PECAM1
intracellular membrane-bounded organelle 3 CCN2, GJA1, PPARG
postsynaptic density 2 BMPR2, CASP3
Single-pass type I membrane protein 1 PECAM1
Secreted 5 ANG, CCN2, IL6, REN, VEGFA
extracellular region 8 ANG, CCN2, IL6, MAPK1, MAPK14, REN, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
transcription regulator complex 1 STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 MAPK1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, CCND1, EDNRB
external side of plasma membrane 2 PECAM1, TNF
Secreted, extracellular space, extracellular matrix 2 CCN2, VEGFA
actin cytoskeleton 1 ANG
nucleolus 1 ANG
Early endosome 1 MAPK1
apical part of cell 1 REN
cell-cell junction 1 PECAM1
clathrin-coated pit 1 BMPR2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Membrane raft 3 GJA1, PECAM1, TNF
pore complex 1 BCL2
Cell junction, focal adhesion 1 MAPK1
Cytoplasm, cytoskeleton, spindle 1 MAPK1
focal adhesion 2 GJA1, MAPK1
spindle 1 MAPK1
extracellular matrix 2 CCN2, VEGFA
basement membrane 1 ANG
secretory granule 1 VEGFA
Cell junction, gap junction 1 GJA1
connexin complex 1 GJA1
contractile muscle fiber 1 GJA1
fascia adherens 1 GJA1
intermediate filament 1 GJA1
lateral plasma membrane 1 GJA1
nuclear speck 1 MAPK14
Late endosome 1 MAPK1
receptor complex 2 BMPR2, PPARG
chromatin 4 GABPA, PCNA, PPARG, STAT3
phagocytic cup 1 TNF
mitotic spindle 1 MAPK1
Chromosome 1 ANG
cytoskeleton 1 MAPK1
Nucleus, nucleolus 1 ANG
spindle pole 1 MAPK14
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Membrane, caveola 1 MAPK1
Golgi-associated vesicle membrane 1 GJA1
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
replication fork 1 PCNA
myelin sheath 1 BCL2
pseudopodium 1 MAPK1
basal plasma membrane 1 BMPR2
ficolin-1-rich granule lumen 2 MAPK1, MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 1 PECAM1
endoplasmic reticulum lumen 2 IL6, MAPK1
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 VEGFA
endocytic vesicle 1 ANG
tight junction 1 GJA1
azurophil granule lumen 1 MAPK1
nuclear lamina 1 PCNA
death-inducing signaling complex 1 CASP3
[Isoform Long]: Cell membrane 1 PECAM1
platelet alpha granule membrane 1 PECAM1
cell-cell contact zone 1 GJA1
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
angiogenin-PRI complex 1 ANG
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform Delta15]: Cell junction 1 PECAM1
cyclin D1-CDK6 complex 1 CCND1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Dufang Ma, Yiwei Qu, Tao Wu, Xue Liu, Lu Cai, Yong Wang. Excessive fat expenditure in MCT-induced heart failure rats is associated with BMAL1/REV-ERBα circadian rhythmic loop disruption. Scientific reports. 2024 04; 14(1):8128. doi: 10.1038/s41598-024-58577-8. [PMID: 38584196]
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  • Qianqian Zhang, Yuqian Chen, Qingting Wang, Yan Wang, Wei Feng, Limin Chai, Jin Liu, Danyang Li, Huan Chen, Yuanjie Qiu, Nirui Shen, Xiangyu Shi, Xinming Xie, Manxiang Li. HMGB1-induced activation of ER stress contributes to pulmonary artery hypertension in vitro and in vivo. Respiratory research. 2023 Jun; 24(1):149. doi: 10.1186/s12931-023-02454-x. [PMID: 37268944]
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  • Qiuxiao Ma, Min Wang, Lanfang Li, Xinyu Zhang, Lixin Cui, Junyu Mou, Guibo Sun, Qiong Zhang. Jiedu Quyu Decoction mitigates monocrotaline-induced right-sided heart failure associated with pulmonary artery hypertension by inhibiting NLRP3 inflammasome in rats. Journal of ethnopharmacology. 2023 May; ?(?):116556. doi: 10.1016/j.jep.2023.116556. [PMID: 37142147]
  • Zhifeng Xue, Mengen Zhou, Yiman Liu, Honglin Qin, Yixuan Li, Yan Zhu, Jian Yang. A modified Fangji Huangqi decoction ameliorates pulmonary artery hypertension via phosphatidylinositide 3-kinases/protein kinase B-mediated regulation of proliferation and apoptosis of smooth muscle cells in vitro and in vivo. Journal of ethnopharmacology. 2023 Apr; ?(?):116544. doi: 10.1016/j.jep.2023.116544. [PMID: 37088239]
  • Anna Krzyżewska, Marta Baranowska-Kuczko, Irena Kasacka, Hanna Kozłowska. Cannabidiol inhibits lung proliferation in monocrotaline-induced pulmonary hypertension in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 159(?):114234. doi: 10.1016/j.biopha.2023.114234. [PMID: 36634588]
  • Adriana L Silva, Joana L Oliveira, Ravena P do Nascimento, Letícia O Santos, Fillipe M de Araújo, Balbino L Dos Santos, Rejane C Santana, Eduardo Luiz T Moreira, Maria José M Batatinha, Iura M Alves, Eudes S Velozo, Mauricio M Victor, Adriano M Assis, Roberto F Almeida, Diogo O G de Souza, Victor Diógenes A Silva, Silvia L Costa. Monocrotaline induces acutely cerebrovascular lesions, astrogliosis and neuronal degeneration associated with behavior changes in rats: A model of vascular damage in perspective. Neurotoxicology. 2023 01; 94(?):59-70. doi: 10.1016/j.neuro.2022.10.017. [PMID: 36336098]
  • Yi Xiao, Haomin Yi, Guofang Wang, Suhua Chen, Xiang Li, Qinyu Wu, Siyi Zhang, Kexin Deng, Yisheng He, Xiaoping Yang. Electrochemiluminescence sensor for point-of-care detection of pyrrolizidine alkaloids. Talanta. 2022 Nov; 249(?):123645. doi: 10.1016/j.talanta.2022.123645. [PMID: 35700647]
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  • Xiaoyi Hu, Qian Wang, Hui Zhao, Wenhui Wu, Qinhua Zhao, Rong Jiang, Jinming Liu, Lan Wang, Ping Yuan. Role of miR-21-5p/FilGAP axis in estradiol alleviating the progression of monocrotaline-induced pulmonary hypertension. Animal models and experimental medicine. 2022 09; 5(3):217-226. doi: 10.1002/ame2.12253. [PMID: 35713208]
  • Hiroto Yamazaki, Hidehiro Tajima, Yasuhiko Yamamoto, Seiichi Munesue, Mitsuyoshi Okazaki, Yoshinao Ohbatake, Shinichi Nakanuma, Isamu Makino, Tomoharu Miyashita, Hiroyuki Takamura, Tetsuo Ohta. Thrombopoietin accumulation in hepatocytes induces a decrease in its serum levels in a sinusoidal obstruction syndrome model. Molecular medicine reports. 2022 Jun; 25(6):. doi: 10.3892/mmr.2022.12717. [PMID: 35475446]
  • Na He, Xuan Li, Zhimin Luo, Lu Wang, Xia Cui, Qiang Fu. Preparation of molecularly imprinted foam for selective extraction of toxic monocrotaline from herbs. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Jun; 1200(?):123273. doi: 10.1016/j.jchromb.2022.123273. [PMID: 35537311]
  • Anna Krzyżewska, Marta Baranowska-Kuczko, Anna Jastrząb, Irena Kasacka, Hanna Kozłowska. Cannabidiol Improves Antioxidant Capacity and Reduces Inflammation in the Lungs of Rats with Monocrotaline-Induced Pulmonary Hypertension. Molecules (Basel, Switzerland). 2022 May; 27(10):. doi: 10.3390/molecules27103327. [PMID: 35630804]
  • Richard Mprah, Yanhong Ma, Gabriel Komla Adzika, Marie Louise Ndzie Noah, Adebayo O Adekunle, Maxwell Duah, Joseph Adu-Amankwaah, Prosperl Ivette Wowui, Jennifer Dumebi Okwuma, Weili Qiao, Cheng Wang. Metabotropic glutamate receptor 5 blockade attenuates pathological cardiac remodelling in pulmonary arterial hypertension. Clinical and experimental pharmacology & physiology. 2022 05; 49(5):558-566. doi: 10.1111/1440-1681.13633. [PMID: 35133684]
  • Izabela Jarabicová, Csaba Horváth, Eva Veľasová, Lenka Bies Piváčková, Jana Vetešková, Ján Klimas, Peter Křenek, Adriana Adameová. Analysis of necroptosis and its association with pyroptosis in organ damage in experimental pulmonary arterial hypertension. Journal of cellular and molecular medicine. 2022 05; 26(9):2633-2645. doi: 10.1111/jcmm.17272. [PMID: 35393789]
  • Yi Tang, Siyuan Tan, Minqi Li, Yijin Tang, Xiaoping Xu, Qinghai Zhang, Qinghua Fu, Mingxiang Tang, Jin He, Yi Zhang, Zhaofen Zheng, Jianqiang Peng, Tengteng Zhu, Wenlin Xie. Dapagliflozin, sildenafil and their combination in monocrotaline-induced pulmonary arterial hypertension. BMC pulmonary medicine. 2022 Apr; 22(1):142. doi: 10.1186/s12890-022-01939-7. [PMID: 35413880]
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  • Di Chen, Tianyi Yuan, Yucai Chen, Huifang Zhang, Ziran Niu, Lianhua Fang, Guanhua Du. DL0805-1, a novel Rho-kinase inhibitor, attenuates lung injury and vasculopathy in a rat model of monocrotaline-induced pulmonary hypertension. European journal of pharmacology. 2022 Mar; 919(?):174779. doi: 10.1016/j.ejphar.2022.174779. [PMID: 35092757]
  • Shan-Shan Xie, Yan Deng, Sheng-Lan Guo, Jia-Quan Li, Ying-Chuan Zhou, Juan Liao, Dan-Dan Wu, Wei-Fang Lan. Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation. Scientific reports. 2022 02; 12(1):3056. doi: 10.1038/s41598-022-06848-7. [PMID: 35197507]
  • Zhuangzhuang Jia, Haifeng Yan, Shuai Wang, Lin Wang, Yawen Cao, Shanshan Lin, Zeyu Zhang, Ci Wang, Xianliang Wang, Jingyuan Mao. Shufeiya Recipe Improves Monocrotaline-Induced Pulmonary Hypertension in Rats by Regulating SIRT3/FOXO3a and Its Downstream Signaling Pathways. Disease markers. 2022; 2022(?):3229888. doi: 10.1155/2022/3229888. [PMID: 35222742]
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  • Feifei Lin, Anni Pan, Yang Ye, Jia Liu. Simultaneous determination of monocrotaline and its N-oxide metabolite in rat plasma using LC-MS/MS: Application to a pharmacokinetic study. Biomedical chromatography : BMC. 2021 Dec; 35(12):e5207. doi: 10.1002/bmc.5207. [PMID: 34184288]
  • Sasha Z Prisco, Megan Eklund, Daphne M Moutsoglou, Anthony R Prisco, Alexander Khoruts, E Kenneth Weir, Thenappan Thenappan, Kurt W Prins. Intermittent Fasting Enhances Right Ventricular Function in Preclinical Pulmonary Arterial Hypertension. Journal of the American Heart Association. 2021 11; 10(22):e022722. doi: 10.1161/jaha.121.022722. [PMID: 34747187]
  • Yingjie Lv, Pengsheng Ma, Jialing Wang, Qingbin Xu, Jun Fan, Lin Yan, Ping Ma, Ru Zhou. Betaine alleviates right ventricular failure via regulation of Rho A/ROCK signaling pathway in rats with pulmonary arterial hypertension. European journal of pharmacology. 2021 Nov; 910(?):174311. doi: 10.1016/j.ejphar.2021.174311. [PMID: 34245749]
  • Firoozeh Farahmand, Akshi Malik, Anita Sharma, Ashim K Bagchi, Pawan K Singal. Role of oxidative stress versus lipids in monocrotaline-induced pulmonary hypertension and right heart failure. Physiological reports. 2021 11; 9(22):e15090. doi: 10.14814/phy2.15090. [PMID: 34816616]
  • Jing-Jing Zhou, Huang Li, Li Li, Yue Li, Pei-He Wang, Xian-Min Meng, Jian-Guo He. CYLD mediates human pulmonary artery smooth muscle cell dysfunction in congenital heart disease-associated pulmonary arterial hypertension. Journal of cellular physiology. 2021 09; 236(9):6297-6311. doi: 10.1002/jcp.30298. [PMID: 33507567]
  • Patrick Diaba-Nuhoho, Martin Cour, Nkanyiso Hadebe, David Marais, Sandrine Lecour, Dee Blackhurst. Chronic and moderate consumption of reduced-alcohol wine confers cardiac benefits in a rat model of pulmonary arterial hypertension. BMC research notes. 2021 Aug; 14(1):324. doi: 10.1186/s13104-021-05738-x. [PMID: 34425891]
  • Laurent Savale, Satoshi Akagi, Ly Tu, Amélie Cumont, Raphaël Thuillet, Carole Phan, Benjamin Le Vely, Nihel Berrebeh, Alice Huertas, Xavier Jaïs, Vincent Cottin, Ari Chaouat, Cécile Tromeur, Athénaïs Boucly, Etienne Marie Jutant, Olaf Mercier, Elie Fadel, David Montani, Olivier Sitbon, Marc Humbert, Yuichi Tamura, Christophe Guignabert. Serum and pulmonary uric acid in pulmonary arterial hypertension. The European respiratory journal. 2021 08; 58(2):. doi: 10.1183/13993003.00332-2020. [PMID: 33446602]
  • Thaïs Hautbergue, Fabrice Antigny, Angèle Boët, François Haddad, Bastien Masson, Mélanie Lambert, Amélie Delaporte, Jean-Baptiste Menager, Laurent Savale, Jérôme Le Pavec, Elie Fadel, Marc Humbert, Christophe Junot, François Fenaille, Benoit Colsch, Olaf Mercier. Right Ventricle Remodeling Metabolic Signature in Experimental Pulmonary Hypertension Models of Chronic Hypoxia and Monocrotaline Exposure. Cells. 2021 06; 10(6):. doi: 10.3390/cells10061559. [PMID: 34205639]
  • Soodeh Rajabi, Hamid Najafipour, Saeideh Jafarinejad-Farsangi, Siyavash Joukar, Ahmad Beik, Majid Askaripour, Elham Jafari, Zohreh Safi. Quercetin, Perillyl Alcohol, and Berberine Ameliorate Right Ventricular Disorders in Experimental Pulmonary Arterial Hypertension: Effects on miR-204, miR-27a, Fibrotic, Apoptotic, and Inflammatory Factors. Journal of cardiovascular pharmacology. 2021 06; 77(6):777-786. doi: 10.1097/fjc.0000000000001015. [PMID: 34016844]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tomohito Ishikawa, Kohtaro Abe, Mariko Takana-Ishikawa, Keimei Yoshida, Takanori Watanabe, Satomi Imakiire, Kazuya Hosokawa, Mayumi Hirano, Katsuya Hirano, Hiroyuki Tsutsui. Chronic Inhibition of Toll-Like Receptor 9 Ameliorates Pulmonary Hypertension in Rats. Journal of the American Heart Association. 2021 04; 10(7):e019247. doi: 10.1161/jaha.120.019247. [PMID: 33787285]
  • Haifeng Jin, Yu Jiao, Linna Guo, Yong Ma, Rongjie Zhao, Xuemei Li, Lei Shen, Zhongguang Zhou, Sang Chan Kim, Jicheng Liu. Astragaloside IV blocks monocrotaline‑induced pulmonary arterial hypertension by improving inflammation and pulmonary artery remodeling. International journal of molecular medicine. 2021 02; 47(2):595-606. doi: 10.3892/ijmm.2020.4813. [PMID: 33416126]
  • Yisheng He, Wei Lian, Liang Ding, Xiaoyu Fan, Jiang Ma, Qing-Yu Zhang, Xinxin Ding, Ge Lin. Lung injury induced by pyrrolizidine alkaloids depends on metabolism by hepatic cytochrome P450s and blood transport of reactive metabolites. Archives of toxicology. 2021 01; 95(1):103-116. doi: 10.1007/s00204-020-02921-0. [PMID: 33033841]
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