Cannabidiol (BioDeep_00000001921)
PANOMIX_OTCML-2023
代谢物信息卡片
1,3-Benzenediol, 2-(3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl)-5-pentyl-, (1R-trans)-
化学式: C21H30O2 (314.224568)
中文名称: 大麻二酚 溶液, 大麻二酚
谱图信息:
最多检出来源 Macaca mulatta(otcml) 0.12%
分子结构信息
SMILES: C1(C=C(CC[C@H]1C(=C)C)C)C1C(O)=CC(CCCCC)=CC=1O
InChI: InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1
描述信息
An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
21 个数据库交叉引用编号
- ChEBI: CHEBI:69478
- KEGG: C07578
- KEGGdrug: D10915
- PubChem: 644019
- PubChem: 26346
- Metlin: METLIN41032
- DrugBank: DB09061
- ChEMBL: CHEMBL190461
- LipidMAPS: LMPK13120005
- LipidMAPS: LMPK13120001
- MeSH: Cannabidiol
- MetaCyc: CPD-7173
- KNApSAcK: C00002641
- CAS: 13956-29-1
- CAS: 3556-78-3
- PMhub: MS000001451
- MetaboLights: MTBLC69478
- PubChem: 9781
- PDB-CCD: P0T
- 3DMET: B05249
- NIKKAJI: J10.356J
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
5 个相关的代谢反应过程信息。
Reactome(0)
WikiPathways(1)
- CBD synthetic pathway:
delta(9)-Tetrahydrocannabinolic acid (D9-THCA) ⟶ Delta(9)-tetrahydrocannabinol (D9-THC)
Plant Reactome(0)
INOH(0)
PlantCyc(3)
- cannabinoid biosynthesis:
Δ9-tetrahydrocannabinolate + H+ ⟶ CO2 + THC - cannabinoid biosynthesis:
Δ9-tetrahydrocannabinolate + H+ ⟶ CO2 + THC - cannabinoid biosynthesis:
H+ + cannabidiolate ⟶ CO2 + cannabidiol
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qianchun Gong, Rendi Jiang, Lina Ji, Haofeng Lin, Meiqin Liu, Xiaofang Tang, Yong Yang, Wei Han, Jing Chen, Zishuo Guo, Qi Wang, Qian Li, Xi Wang, Tingting Jiang, Shizhe Xie, Xinglou Yang, Peng Zhou, Zhengli Shi, Xinhua Lin. Establishment of a human organoid-based evaluation system for assessing interspecies infection risk of animal-borne coronaviruses.
Emerging microbes & infections.
2024 Dec; 13(1):2327368. doi:
10.1080/22221751.2024.2327368. [PMID: 38531008] - Jenny L Wiley, Julie A Marusich, Bruce E Blough, Ojas Namjoshi, Marcus Brackeen, Luli R Akinfiresoye, Teneille D Walker, Cassandra Prioleau, Daniel G Barrus, Thomas F Gamage. Evaluation of cannabimimetic effects of selected minor cannabinoids and Terpenoids in mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2024 Jun; 132(?):110984. doi:
10.1016/j.pnpbp.2024.110984. [PMID: 38417478] - Dana A Page, Peter C Ruben. Cannabidiol potentiates hyperpolarization-activated cyclic nucleotide-gated (HCN4) channels.
The Journal of general physiology.
2024 Jun; 156(6):. doi:
10.1085/jgp.202313505. [PMID: 38652080] - Bing-Qian Ma, Jian-Xin Jia, He Wang, Si-Jia Li, Zhan-Jun Yang, Xin-Xin Wang, Xu-Sheng Yan. Cannabidiol improves the cognitive function of SAMP8 AD model mice involving the microbiota-gut-brain axis.
Journal of toxicology and environmental health. Part A.
2024 Jun; 87(11):471-479. doi:
10.1080/15287394.2024.2338914. [PMID: 38590254] - Renata Vardanega, Fernanda L Lüdtke, Luís Loureiro, Raquel F S Gonçalves, Ana C Pinheiro, António A Vicente. Development and characterization of nanostructured lipid carriers for cannabidiol delivery.
Food chemistry.
2024 May; 441(?):138295. doi:
10.1016/j.foodchem.2023.138295. [PMID: 38183719] - N Koch, O Jennotte, Q Bourcy, A Lechanteur, M Deville, C Charlier, P Chiap, J M Cardot, B Evrard. Evaluation of amorphous and lipid-based formulation strategies to increase the in vivo cannabidiol bioavailability in piglets.
International journal of pharmaceutics.
2024 May; 657(?):124173. doi:
10.1016/j.ijpharm.2024.124173. [PMID: 38685441] - Ahmed Adel Ali Youssef, Muna Hayder Abdelrahman, Mona M Geweda, Corinne Varner, Poorva H Joshi, Mihir Ghonge, Narendar Dudhipala, Suresh P Sulochana, Rama S Gadepalli, Soumyajit Majumdar. Formulation and In Vitro-Ex vivo Evaluation of Cannabidiol and Cannabidiol-Valine-Hemisuccinate Loaded Lipid-Based Nanoformulations for Ocular Applications.
International journal of pharmaceutics.
2024 May; 657(?):124110. doi:
10.1016/j.ijpharm.2024.124110. [PMID: 38604539] - Huifang Li, Tess Puopolo, Navindra P Seeram, Chang Liu, Hang Ma. Anti-Ferroptotic Effect of Cannabidiol in Human Skin Keratinocytes Characterized by Data-Independent Acquisition-Based Proteomics.
Journal of natural products.
2024 May; 87(5):1493-1499. doi:
10.1021/acs.jnatprod.3c00759. [PMID: 38373879] - Si Huang, Teris A van Beek, Frank W Claassen, Hans-Gerd Janssen, Ming Ma, Bo Chen, Han Zuilhof, G Ij Salentijn. Comprehensive cannabinoid profiling of acid-treated CBD samples and Δ8-THC-infused edibles.
Food chemistry.
2024 May; 440(?):138187. doi:
10.1016/j.foodchem.2023.138187. [PMID: 38134831] - Tenghan Ling, Aiping Yin, Yan Cao, Jiali Li, Hengxi Li, Ying Zhou, Xiaobing Guo, Jinghui Li, Ruilin Zhang, Haiying Wu, Ping Li. Purinergic Astrocyte Signaling Driven by TNF-α After Cannabidiol Administration Restores Normal Synaptic Remodeling Following Traumatic Brain Injury.
Neuroscience.
2024 May; 545(?):31-46. doi:
10.1016/j.neuroscience.2024.03.002. [PMID: 38460903] - Daniela Gruľová, Beáta Baranová, Rosaria Francolino, Hazem S Elshafie, Zuzana Kiššová, Alžbeta Glovaťáková, Laura De Martino, Giuseppe Amato, Mara Martino, Lucia Caputo, Flavio Polito, Francesco Manna, Ippolito Camele, Ľudmila Tkáčiková, Vincenzo De Feo. Exploring the Diverse Biological Properties of Cannabidiol: A Focus on Plant Growth Stimulation.
Chemistry & biodiversity.
2024 May; 21(5):e202400274. doi:
10.1002/cbdv.202400274. [PMID: 38466647] - Céline Duchateau, Caroline Stévigny, Kris De Braekeleer, Eric Deconinck. Characterization of CBD oils, seized on the Belgian market, using infrared spectroscopy: Matrix identification and CBD determination, a proof of concept.
Drug testing and analysis.
2024 May; 16(5):537-551. doi:
10.1002/dta.3583. [PMID: 37793648] - Khent Primo Alcantara, John Wilfred T Malabanan, Nonthaneth Nalinratana, Worathat Thitikornpong, Pornchai Rojsitthisak, Pranee Rojsitthisak. Cannabidiol-Loaded Solid Lipid Nanoparticles Ameliorate the Inhibition of Proinflammatory Cytokines and Free Radicals in an In Vitro Inflammation-Induced Cell Model.
International journal of molecular sciences.
2024 Apr; 25(9):. doi:
10.3390/ijms25094744. [PMID: 38731964] - Li Ma, Mengke Liu, Chuntong Liu, Huachang Zhang, Shude Yang, Jing An, Guiwu Qu, Shuling Song, Qizhi Cao. Research Progress on the Mechanism of the Antitumor Effects of Cannabidiol.
Molecules (Basel, Switzerland).
2024 Apr; 29(9):. doi:
10.3390/molecules29091943. [PMID: 38731434] - Nicoleta Mirela Blebea, Andreea Iulia Pricopie, Robert-Alexandru Vlad, Gabriel Hancu. Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use.
International journal of molecular sciences.
2024 Apr; 25(8):. doi:
10.3390/ijms25084204. [PMID: 38673788] - Meghan S Cahill, Terri Arsenault, Trung Huu Bui, Nubia Zuverza-Mena, Anuja Bharadwaj, Kitty Prapayotin-Riveros, Jason C White, Christian O Dimkpa. Copper Stimulation of Tetrahydrocannabinol and Cannabidiol Production in Hemp (Cannabis sativa L.) Is Copper-Type, Dose, and Cultivar Dependent.
Journal of agricultural and food chemistry.
2024 Apr; 72(13):6921-6930. doi:
10.1021/acs.jafc.3c07819. [PMID: 38516700] - Sadikalmahdi Abdella, Sangseo Kim, Franklin Afinjuomo, Yunmei Song, Richard Upton, Sanjay Garg. Combining the potential of 3D printed buccal films and nanostructured lipid carriers for personalised cannabidiol delivery.
Drug delivery and translational research.
2024 Apr; 14(4):984-1004. doi:
10.1007/s13346-023-01446-0. [PMID: 37903964] - Camila Belen Martinena, Merlina Corleto, Melina María Belén Martínez, Nicolás Oscar Amiano, Verónica Edith García, Paulo Cesar Maffia, Nancy Liliana Tateosian. Antimicrobial Effect of Cannabidiol on Intracellular Mycobacterium tuberculosis.
Cannabis and cannabinoid research.
2024 Apr; 9(2):464-469. doi:
10.1089/can.2023.0124. [PMID: 38252548] - Albatul S Almousa, Pandurangan Subash-Babu, Ibrahim O Alanazi, Ali A Alshatwi, Huda Alkhalaf, Eman Bahattab, Atheer Alsiyah, Mohammad Alzahrani. Hemp Seed Oil Inhibits the Adipogenicity of the Differentiation-Induced Human Mesenchymal Stem Cells through Suppressing the Cannabinoid Type 1 (CB1).
Molecules (Basel, Switzerland).
2024 Mar; 29(7):. doi:
10.3390/molecules29071568. [PMID: 38611847] - Zeeta Bawa, Danielle McCartney, Miguel Bedoya-Pérez, Namson S Lau, Richard Fox, Hamish MacDougall, Iain S McGregor. Effects of cannabidiol on psychosocial stress, situational anxiety and nausea in a virtual reality environment: a protocol for a single-centre randomised clinical trial.
BMJ open.
2024 Mar; 14(3):e082927. doi:
10.1136/bmjopen-2023-082927. [PMID: 38531572] - Guangzhao Shu, Yang He, Jin Suo, Chunhui Wu, Xudong Gong, Yangyang Xiang, Wenjiao Yang, Jiaxin Cheng, Yu Wang, Weiming Chen, Jingshan Shen. Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models.
Neuroscience letters.
2024 Mar; 826(?):137723. doi:
10.1016/j.neulet.2024.137723. [PMID: 38467272] - Radhika Anand, Ritu Painuli, Vijay Kumar, Parvinder Pal Singh. Chemistry and pharmacological aspects of furanoid cannabinoids and related compounds: Is furanoid cannabinoids open a new dimension towards the non-psychoactive cannabinoids?.
European journal of medicinal chemistry.
2024 Mar; 268(?):116164. doi:
10.1016/j.ejmech.2024.116164. [PMID: 38417219] - Tina Podinic, Louise Limoges, Cristina Monaco, Andie MacAndrew, Mahek Minhas, Joshua Nederveen, Sandeep Raha. Cannabidiol Disrupts Mitochondrial Respiration and Metabolism and Dysregulates Trophoblast Cell Differentiation.
Cells.
2024 Mar; 13(6):. doi:
10.3390/cells13060486. [PMID: 38534330] - Olivia Cresswell, Karis Blankenship, Barbara L F Kaplan. Development of an in vitro peptide-stimulated T cell assay to evaluate immune effects by cannabinoid compounds.
International immunopharmacology.
2024 Mar; 129(?):111654. doi:
10.1016/j.intimp.2024.111654. [PMID: 38335658] - Sreejarani Kesavan Pillai, Nazia Hassan Kera, Phumelele Kleyi, Marinda de Beer, Matin Magwaza, Suprakas Sinha Ray. Stability, biofunctional, and antimicrobial characteristics of cannabidiol isolate for the design of topical formulations.
Soft matter.
2024 Mar; 20(10):2348-2360. doi:
10.1039/d3sm01466e. [PMID: 38372296] - Aleksandra Opęchowska, Kacper Karpiuk, Andrii Zahorodnii, Ewa Harasim-Symbor, Adrian Chabowski, Karolina Konstantynowicz-Nowicka. Anti-inflammatory effects of cannabidiol in early stages of neuroinflammation induced by high-fat diet in cerebral cortex of rats.
Toxicology and applied pharmacology.
2024 Mar; 484(?):116856. doi:
10.1016/j.taap.2024.116856. [PMID: 38336253] - Wenjiao Yang, Xudong Gong, Haiguo Sun, Chunhui Wu, Jin Suo, Jing Ji, Xiangrui Jiang, Jingshan Shen, Yang He, Haji Akber Aisa. Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety.
European journal of medicinal chemistry.
2024 Feb; 265(?):116048. doi:
10.1016/j.ejmech.2023.116048. [PMID: 38150961] - Xiaohui Yang, Dohyeon Lee, Hyun-Woo Kim, Byung-Hyun Park, Changjin Lim, Eun Ju Bae. Cannabidiol Inhibits IgE-Mediated Mast Cell Degranulation and Anaphylaxis in Mice.
Molecular nutrition & food research.
2024 Feb; 68(3):e2300136. doi:
10.1002/mnfr.202300136. [PMID: 38059783] - Anne T Berg, Tracy Dixon-Salazar, Mary Anne Meskis, Sherry R Danese, Ngoc Minh D Le, M Scott Perry. Caregiver-reported outcomes with real-world use of cannabidiol in Lennox-Gastaut syndrome and Dravet syndrome from the BECOME survey.
Epilepsy research.
2024 Feb; 200(?):107280. doi:
10.1016/j.eplepsyres.2023.107280. [PMID: 38183688] - Alejandra Delgado-Sequera, Clara Garcia-Mompo, Ana Gonzalez-Pinto, Maria Hidalgo-Figueroa, Esther Berrocoso. A Systematic Review of the Molecular and Cellular Alterations Induced by Cannabis That May Serve as Risk Factors for Bipolar Disorder.
The international journal of neuropsychopharmacology.
2024 Feb; 27(2):. doi:
10.1093/ijnp/pyae002. [PMID: 38175142] - Jessica N Wilson, Dora A Mendez, Francis Dhoro, Nikolay Shevchenko, Mark Mascal, Kyle Lund, Robert Fitzgerald, Nicholas V DiPatrizio, Rudy M Ortiz. Pseudocannabinoid H4CBD improves glucose response during advanced metabolic syndrome in OLETF rats independent of increase in insulin signaling proteins.
American journal of physiology. Regulatory, integrative and comparative physiology.
2024 02; 326(2):R100-R109. doi:
10.1152/ajpregu.00125.2022. [PMID: 37899754] - Michael R Haupts, Ute Essner, Mathias Mäurer. Patient-reported benefits from nabiximols treatment in multiple sclerosis-related spasticity exceed conventional measures.
Neurodegenerative disease management.
2024 Feb; 14(1):11-20. doi:
10.2217/nmt-2023-0040. [PMID: 38318862] - Carole M Lindsay, Khalia K Bernard, Amanda M Hammond, Sheldon Beckford, Wendel D Abel, Paul D Brown, Lauriann E Young. Potency trends of cannabis in Jamaica during the period of 2014 to 2020.
Drug testing and analysis.
2024 Feb; 16(2):174-186. doi:
10.1002/dta.3527. [PMID: 37309060] - Petr Jelínek, Jaroslava Roušarová, Pavel Ryšánek, Martina Ježková, Tereza Havlůjová, Jiří Pozniak, Petr Kozlík, Tomáš Křížek, Tomáš Kučera, Martin Šíma, Ondřej Slanař, Miroslav Šoóš. Application of Oil-in-Water Cannabidiol Emulsion for the Treatment of Rheumatoid Arthritis.
Cannabis and cannabinoid research.
2024 02; 9(1):147-159. doi:
10.1089/can.2022.0176. [PMID: 36342775] - Alberto Sainz-Cort, Daniel Jimenez-Garrido, Elena Muñoz-Marron, Raquel Viejo-Sobera, Joost Heeroma, Jose Carlos Bouso. The Effects of Cannabidiol and δ-9-Tetrahydrocannabinol in Social Cognition: A Naturalistic Controlled Study.
Cannabis and cannabinoid research.
2024 02; 9(1):230-240. doi:
10.1089/can.2022.0037. [PMID: 35881851] - Evangelos Dadiotis, Meng Cui, Maria Gerasi, Vangelis Mitsis, Eleni Melliou, Alexandros Makriyannis, Diomedes E Logothetis, Prokopios Magiatis. A Simple Chiral 1H NMR Method for the Discrimination of (R)- and (S)-Cannabichromene in Complex Natural Mixtures and Their Effects on TRPA1 Activity.
Journal of natural products.
2024 Jan; 87(1):77-84. doi:
10.1021/acs.jnatprod.3c00796. [PMID: 38158562] - Dimakatso Mokoena, Blassan P George, Heidi Abrahamse. Cannabidiol Combination Enhances Photodynamic Therapy Effects on MCF-7 Breast Cancer Cells.
Cells.
2024 01; 13(2):. doi:
10.3390/cells13020187. [PMID: 38247877] - Fernanda Frederico Gava, Raquel Jaconi De Carli, Solange Stork, Lucineia Gainski Danielski, Sandra Bonfante, Larissa Joaquim, Kiuanne Lino Lobo Metzker, Khiany Mathias, David Santos, Guilherme Darós, Marina Goulart, Rafael Mariano de Bitencourt, Josiane Somariva Prophiro, Cinara Ludvig Gonçalves, Jaqueline Generoso, Tatiana Barichello, Fabricia Petronilho. Cannabidiol effect on long-term brain alterations in septic rats: Involvement of PPARγ activation.
Brain research.
2024 Jan; 1828(?):148771. doi:
10.1016/j.brainres.2024.148771. [PMID: 38242525] - Adi Eitan, Ofer Gover, Liron Sulimani, David Meiri, Naama Shterzer, Erez Mills, Betty Schwartz. The Effect of Oil-Based Cannabis Extracts on Metabolic Parameters and Microbiota Composition of Mice Fed a Standard and a High-Fat Diet.
International journal of molecular sciences.
2024 Jan; 25(2):. doi:
10.3390/ijms25021073. [PMID: 38256146] - Ahmad K Al-Khazaleh, Xian Zhou, Deep Jyoti Bhuyan, Gerald W Münch, Elaf Adel Al-Dalabeeh, Kayla Jaye, Dennis Chang. The Neurotherapeutic Arsenal in Cannabis sativa: Insights into Anti-Neuroinflammatory and Neuroprotective Activity and Potential Entourage Effects.
Molecules (Basel, Switzerland).
2024 Jan; 29(2):. doi:
10.3390/molecules29020410. [PMID: 38257323] - Jefree J Raslan-Jaramillo, Gisela A Ríos-Gajardo, Marcia A Avello, Marta G de Diego. Determination of Cannabinoids in Cannabis sativa Oil and Infused Ice Cream by LC-DAD Method.
Journal of AOAC International.
2024 Jan; 107(1):140-145. doi:
10.1093/jaoacint/qsad122. [PMID: 37819769] - Estácio Amaro da Silva, Wandersonia Moreira Brito Medeiros, João Paulo Mendes Dos Santos, João Marçal Medeiros de Sousa, Filipe Barbosa da Costa, Katiúscia Moreira Pontes, Thaís Cavalcanti Borges, Carlos Espínola, Ana Hermínia Andrade E Silva, Eliane Lima Guerra Nunes, Nelson Torro Alves, Marine Diniz da Rosa, Katy Lísias Gondim Dias de Albuquerque. Evaluation of the efficacy and safety of cannabidiol-rich cannabis extract in children with autism spectrum disorder: randomized, double-blind, and placebo-controlled clinical trial.
Trends in psychiatry and psychotherapy.
2024; 46(?):e20210396. doi:
10.47626/2237-6089-2021-0396. [PMID: 35617670] - Giulia Mastellone, Arianna Marengo, Barbara Sgorbini, Patrizia Rubiolo, Jared L Anderson, Cecilia Cagliero. Ultrasound-assisted dispersive solid-liquid microextraction with eutectic solvents for the determination of cannabinoids in different hemp products.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2024 Jan; 1232(?):123967. doi:
10.1016/j.jchromb.2023.123967. [PMID: 38113724] - Aguo Cheng, Suohui Zhang, Fanda Meng, Mengzhen Xing, Han Liu, Guozhong Yang, Yunhua Gao. Nanosuspension-Loaded Dissolving Microneedle Patches for Enhanced Transdermal Delivery of a Highly Lipophilic Cannabidiol.
International journal of nanomedicine.
2024; 19(?):4061-4079. doi:
10.2147/ijn.s452207. [PMID: 38736651] - Xin Xu, Lisa A Murphy. Fast and sensitive LC-MS/MS method for quantification of cannabinoids and their metabolites in plasma of cattle fed hemp.
Journal of separation science.
2024 Jan; 47(1):e2300630. doi:
10.1002/jssc.202300630. [PMID: 37904320] - Dymphy Houtzager, Sergio Armenta, José Manuel Herrero-Martínez, Héctor Martínez-Pérez-Cejuela. Miniaturized paper-based analytical device for the portable analysis of phyto-cannabinoids in plant and oral fluids.
Analytical and bioanalytical chemistry.
2024 Jan; 416(1):255-264. doi:
10.1007/s00216-023-05013-x. [PMID: 37924377] - Run Ma, Na Xie, Yuanhui Shu, Yafeng Wu, Ping He, Yining Xiang, Yan Zhou, Yuping Wang. Cannabidiol alleviates carbon tetrachloride-induced liver fibrosis in mice by regulating NF-κB and PPAR-α pathways.
Experimental biology and medicine (Maywood, N.J.).
2024; 249(?):10141. doi:
10.3389/ebm.2024.10141. [PMID: 38711461] - Isabela Fernandes Pereira, Ana Maria Santos Oliveira, Anamaria Mendonça Santos, Denis de Melo Soares, Mairim Russo Serafini, Izabel Almeida Alves. A Descriptive Review of Cannabis sativa Patents for Cancer Treatment.
Recent patents on anti-cancer drug discovery.
2024; 19(2):137-145. doi:
10.2174/1574892818666230213095717. [PMID: 36788702] - Brandi Patrice Smith, Brooke Hoots, Lara DePadilla, Douglas R Roehler, Kristin M Holland, Daniel A Bowen, Steven A Sumner. Using Transformer-Based Topic Modeling to Examine Discussions of Delta-8 Tetrahydrocannabinol: Content Analysis.
Journal of medical Internet research.
2023 12; 25(?):e49469. doi:
10.2196/49469. [PMID: 38127427] - Lukas K Peltner, Lars Gluthmann, Friedemann Börner, Simona Pace, Robert K Hoffstetter, Christian Kretzer, Rosella Bilancia, Federica Pollastro, Andreas Koeberle, Giovanni Appendino, Antonietta Rossi, Marcia E Newcomer, Nathaniel C Gilbert, Oliver Werz, Paul M Jordan. Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators.
Cell chemical biology.
2023 12; 30(12):1508-1524.e7. doi:
10.1016/j.chembiol.2023.08.001. [PMID: 37647900] - Michaela Bartončíková, Barbora Lapčíková, Lubomír Lapčík, Tomáš Valenta. Hemp-Derived CBD Used in Food and Food Supplements.
Molecules (Basel, Switzerland).
2023 Dec; 28(24):. doi:
10.3390/molecules28248047. [PMID: 38138537] - Michael Pökl, Akshay Sridhar, Damon J A Frampton, Veronika A Linhart, Lucie Delemotte, Sara I Liin. Subtype-specific modulation of human KV 7 channels by the anticonvulsant cannabidiol through a lipid-exposed pore-domain site.
British journal of pharmacology.
2023 12; 180(23):2956-2972. doi:
10.1111/bph.16183. [PMID: 37377025] - Yuxi Li, Xilin Li, Patrick Cournoyer, Supratim Choudhuri, Lei Guo, Si Chen. Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells.
Archives of toxicology.
2023 Dec; 97(12):3227-3241. doi:
10.1007/s00204-023-03609-x. [PMID: 37794255] - Erez Berman, Natalia Erenburg, Ron Beloosesky, Sara Eyal, Michal Kovo. Placental disposition of cannabidiol: An ex vivo perfusion study.
Epilepsia.
2023 Dec; 64(12):3354-3364. doi:
10.1111/epi.17778. [PMID: 37777821] - Inbar Shreiber-Livne, Liron Sulimani, Anna Shapira, Shiri Procaccia, David Meiri, Alejandro Sosnik. Poly(ethylene glycol)-b-poly(epsilon-caprolactone) nanoparticles as a platform for the improved oral delivery of cannabidiol.
Drug delivery and translational research.
2023 12; 13(12):3192-3203. doi:
10.1007/s13346-023-01380-1. [PMID: 37341881] - Paweł Śledziński, Agnieszka Nowak-Terpiłowska, Piotr Rzymski, Ryszard Słomski, Joanna Zeyland. In Vitro Evidence of Selective Pro-Apoptotic Action of the Pure Cannabidiol and Cannabidiol-Rich Extract.
Molecules (Basel, Switzerland).
2023 Dec; 28(23):. doi:
10.3390/molecules28237887. [PMID: 38067615] - Adi Gabarin, Ludmila Yarmolinsky, Arie Budovsky, Boris Khalfin, Shimon Ben-Shabat. Cannabis as a Source of Approved Drugs: A New Look at an Old Problem.
Molecules (Basel, Switzerland).
2023 Nov; 28(23):. doi:
10.3390/molecules28237686. [PMID: 38067416] - Kyudam Choi, Yurim Lee, Cheongwon Kim. An In Silico Study for Expanding the Utility of Cannabidiol in Alzheimer's Disease Therapeutic Development.
International journal of molecular sciences.
2023 Nov; 24(21):. doi:
10.3390/ijms242116013. [PMID: 37959001] - Xiuli Wang, Huanbang Zhang, Yan Liu, Yang Xu, Bingyou Yang, Hua Li, Lixia Chen. An overview on synthetic and biological activities of cannabidiol (CBD) and its derivatives.
Bioorganic chemistry.
2023 11; 140(?):106810. doi:
10.1016/j.bioorg.2023.106810. [PMID: 37659147] - Clare Brown, Matthew Mitsch, Karis Blankenship, Carly Campbell, Mimi Pelanne, Jaylan Sears, Abigail Bell, Alicia K Olivier, Matthew K Ross, Todd Archer, Barbara L F Kaplan. Canine immune cells express high levels of CB1 and CB2 cannabinoid receptors and cannabinoid-mediated alteration of canine cytokine production is vehicle-dependent.
Veterinary immunology and immunopathology.
2023 Oct; 265(?):110667. doi:
10.1016/j.vetimm.2023.110667. [PMID: 37931433] - Wanwisa Deenin, Nadine Wenninger, Martin G Schmid, Kurt Kalcher, Astrid Ortner, Sudkate Chaiyo. Rapid electrochemical lateral flow device for the detection of Δ9-tetrahydrocannabinol.
Analytica chimica acta.
2023 Oct; 1279(?):341768. doi:
10.1016/j.aca.2023.341768. [PMID: 37827668] - Viktor Sedlmayr, Christina Horn, David Johannes Wurm, Oliver Spadiut, Julian Quehenberger. Archaeosomes facilitate storage and oral delivery of cannabidiol.
International journal of pharmaceutics.
2023 Oct; 645(?):123434. doi:
10.1016/j.ijpharm.2023.123434. [PMID: 37739097] - Mark Zamansky, Doron Yariv, Valeria Feinshtein, Shimon Ben-Shabat, Amnon C Sintov. Cannabidiol-Loaded Lipid-Stabilized Nanoparticles Alleviate Psoriasis Severity in Mice: A New Approach for Improved Topical Drug Delivery.
Molecules (Basel, Switzerland).
2023 Oct; 28(19):. doi:
10.3390/molecules28196907. [PMID: 37836750] - Suhas Ganesh, Jose Cortes-Briones, Ashley M Schnakenberg Martin, Patrick D Skosnik, Deepak C D'Souza, Mohini Ranganathan. Delta-9-Tetrahydrocannabinol, Cannabidiol, and Acute Psychotomimetic States: A Balancing Act of the Principal Phyto-Cannabinoids on Human Brain and Behavior.
Cannabis and cannabinoid research.
2023 10; 8(5):846-856. doi:
10.1089/can.2021.0166. [PMID: 35319274] - Adam M Gilmore, Mostafa A Elhendawy, Mohamed M Radwan, Linda H Kidder, Amira S Wanas, Murrell Godfrey, Jana B Hildreth, A Edward Robinson, Mahmoud A ElSohly. Absorbance-Transmittance Excitation Emission Matrix Method for Quantification of Major Cannabinoids and Corresponding Acids: A Rapid Alternative to Chromatography for Rapid Chemotype Discrimination of Cannabis sativa Varieties.
Cannabis and cannabinoid research.
2023 10; 8(5):911-922. doi:
10.1089/can.2021.0165. [PMID: 35486823] - Yener Özel, İbrahim Çavuş, Mehmet Ünlü, Ahmet Özbilgin. [Investigation of the Efficacy of Cinnamaldehyde, Cannabidiol and Eravacycline in a Malaria Model].
Mikrobiyoloji bulteni.
2023 Oct; 57(4):608-624. doi:
10.5578/mb.20239949. [PMID: 37885389] - Bartłomiej Kulesza, Marek Mazurek, Jacek Kurzepa. Can cannabidiol (CBD) help with low back pain?.
Annals of agricultural and environmental medicine : AAEM.
2023 Sep; 30(3):549-554. doi:
10.26444/aaem/168674. [PMID: 37772533] - Wojciech Łuczaj, Izabela Dobrzyńska, Elżbieta Skrzydlewska. Differences in the phospholipid profile of melanocytes and melanoma cells irradiated with UVA and treated with cannabigerol and cannabidiol.
Scientific reports.
2023 Sep; 13(1):16121. doi:
10.1038/s41598-023-43363-9. [PMID: 37752196] - Khondker Rufaka Hossain, Amani Alghalayini, Stella M Valenzuela. Current Challenges and Opportunities for Improved Cannabidiol Solubility.
International journal of molecular sciences.
2023 Sep; 24(19):. doi:
10.3390/ijms241914514. [PMID: 37833962] - Eve O'Reilly, Karima Khalifa, Joanne Cosgrave, Haleema Azam, Maria Prencipe, Jeremy C Simpson, William M Gallagher, Antoinette S Perry. Cannabidiol Inhibits the Proliferation and Invasiveness of Prostate Cancer Cells.
Journal of natural products.
2023 Sep; ?(?):. doi:
10.1021/acs.jnatprod.3c00363. [PMID: 37703852] - Dylan T Marsh, Ayato Sugiyama, Yuta Imai, Ryuji Kato, Scott D Smid. The structurally diverse phytocannabinoids cannabichromene, cannabigerol and cannabinol significantly inhibit amyloid β-evoked neurotoxicity and changes in cell morphology in PC12 cells.
Basic & clinical pharmacology & toxicology.
2023 Sep; ?(?):. doi:
10.1111/bcpt.13943. [PMID: 37697481] - Adi Eitan, Ofer Gover, Liron Sulimani, David Meiri, Betty Schwartz. The Effect of Orally Administered Δ9-Tetrahydrocannabinol (THC) and Cannabidiol (CBD) on Obesity Parameters in Mice.
International journal of molecular sciences.
2023 Sep; 24(18):. doi:
10.3390/ijms241813797. [PMID: 37762099] - Jared S Wood, William H Gordon, Jeremy B Morgan, R Thomas Williamson. Cannabicitran: Its unexpected racemic nature and potential origins.
Chirality.
2023 09; 35(9):540-548. doi:
10.1002/chir.23571. [PMID: 37142400] - Beatriz Correia, Samir Marcos Ahmad, Alexandre Quintas. Determination of phytocannabinoids in cannabis samples by ultrasound-assisted solid-liquid extraction and high-performance liquid chromatography with diode array detector analysis.
Journal of chromatography. A.
2023 Aug; 1705(?):464191. doi:
10.1016/j.chroma.2023.464191. [PMID: 37454455] - Van Nguyen Tran, Ondřej Strnad, Jáchym Šuman, Tereza Veverková, Adéla Sukupová, Pavel Cejnar, Radovan Hynek, Olga Kronusová, Josef Šach, Petr Kaštánek, Tomáš Ruml, Jitka Viktorová. Cannabidiol nanoemulsion for eye treatment - Anti-inflammatory, wound healing activity and its bioavailability using in vitro human corneal substitute.
International journal of pharmaceutics.
2023 Aug; 643(?):123202. doi:
10.1016/j.ijpharm.2023.123202. [PMID: 37406946] - Fresia Melina Silva Sofrás, Rosario Alonso, Daiana Sabrina Retta, Paola Di Leo Lira, Martin Federico Desimone, Catalina María van Baren. Development and Validation of a Simple, Fast, and Accessible HPLC-UV Method for Cannabinoids Determination in Cannabis sativa L. Extracts and Medicinal Oils.
Current pharmaceutical design.
2023 Aug; ?(?):. doi:
10.2174/1381612829666230809094304. [PMID: 37559239] - Nadia Martinez Naya, Jazmin Kelly, Giuliana Corna, Michele Golino, Antonio Abbate, Stefano Toldo. Molecular and Cellular Mechanisms of Action of Cannabidiol.
Molecules (Basel, Switzerland).
2023 Aug; 28(16):. doi:
10.3390/molecules28165980. [PMID: 37630232] - Adam Wroński, Izabela Dobrzyńska, Szymon Sękowski, Wojciech Łuczaj, Ewa Olchowik-Grabarek, Elżbieta Skrzydlewska. Cannabidiol and Cannabigerol Modify the Composition and Physicochemical Properties of Keratinocyte Membranes Exposed to UVA.
International journal of molecular sciences.
2023 Aug; 24(15):. doi:
10.3390/ijms241512424. [PMID: 37569799] - Sha Jin, Cong Lin, Yibo Wang, Hongshuang Wang, Xin Wen, Peng Xiao, Xiaodong Li, Yinghua Peng, Jinpeng Sun, Yuyuan Lu, Xiaohui Wang. Cannabidiol Analogue CIAC001 for the Treatment of Morphine-Induced Addiction by Targeting PKM2.
Journal of medicinal chemistry.
2023 Aug; ?(?):. doi:
10.1021/acs.jmedchem.3c01029. [PMID: 37531582] - Klaudia Sztolsztener, Wiktor Bzdęga, Karolina Konstantynowicz-Nowicka, Adrian Chabowski, Ewa Harasim-Symbor. Therapeutic effect of cannabidiol on myocardial arachidonic acid content in various lipid fractions in a rat model of obesity.
Prostaglandins & other lipid mediators.
2023 Aug; 169(?):106767. doi:
10.1016/j.prostaglandins.2023.106767. [PMID: 37541613] - Hongying Daisy Dai, Roma Subramanian, Avina Mahroke, Ming Wang. Prevalence and Factors Associated With Vaping Cannabidiol Among US Adolescents.
JAMA network open.
2023 08; 6(8):e2329167. doi:
10.1001/jamanetworkopen.2023.29167. [PMID: 37585202] - Shuai Li, Chunxiang Fan, Xu Li, Shanshan Li, Tianfei Yu, Weiwei Zhang, Tianyi Ma, Ming Zhao, Deshan Li, Wei Xiao, Shanan Shan. Cannabidiol ameliorates inflammatory response partly by AGE-RAGE pathway in diabetic mice.
Drug development research.
2023 Jul; ?(?):. doi:
10.1002/ddr.22093. [PMID: 37486107] - Andrey F L Aguiar, Raquel M P Campos, Alinny R Isaac, Yolanda Paes-Colli, Virgínia M Carvalho, Luzia S Sampaio, Ricardo A de Melo Reis. Long-Term Treatment with Cannabidiol-Enriched Cannabis Extract Induces Synaptic Changes in the Adolescent Rat Hippocampus.
International journal of molecular sciences.
2023 Jul; 24(14):. doi:
10.3390/ijms241411775. [PMID: 37511537] - J Maia, B M Fonseca, N Teixeira, G Correia-da-Silva. Unveiling the angiogenic effects of cannabinoids: Enhancers or inhibitors?.
Biochemical pharmacology.
2023 Jul; 215(?):115686. doi:
10.1016/j.bcp.2023.115686. [PMID: 37463627] - Fabiana Russo, Maria Angela Vandelli, Giuseppe Biagini, Martin Schmid, Livio Luongo, Michela Perrone, Federica Ricciardi, Sabatino Maione, Aldo Laganà, Anna Laura Capriotti, Alfonso Gallo, Luigi Carbone, Elisabetta Perrone, Giuseppe Gigli, Giuseppe Cannazza, Cinzia Citti. Synthesis and pharmacological activity of the epimers of hexahydrocannabinol (HHC).
Scientific reports.
2023 Jul; 13(1):11061. doi:
10.1038/s41598-023-38188-5. [PMID: 37422571] - Silvia Franzè, Caterina Ricci, Elena Del Favero, Francesco Rama, Antonella Casiraghi, Francesco Cilurzo. Micelles-in-Liposome Systems Obtained by Proliposomal Approach for Cannabidiol Delivery: Structural Features and Skin Penetration.
Molecular pharmaceutics.
2023 07; 20(7):3393-3402. doi:
10.1021/acs.molpharmaceut.3c00044. [PMID: 37306238] - Maíra Kerpel Dos Santos, Alexander Acosta, Ryan Capote, Bakhtawar Tabassam, James Ley, Martin Quirke, José Almirall. Chemical identification and optimization of the 4-aminophenol colorimetric test for the differentiation between hemp-type and marijuana-type cannabis plant samples.
Journal of forensic sciences.
2023 Jul; 68(4):1162-1177. doi:
10.1111/1556-4029.15309. [PMID: 37357497] - Stéphane Auvin, Charlotte Nortvedt, Douglas S Fuller, Farhad Sahebkar. Seizure-free days as a novel outcome in patients with Lennox-Gastaut syndrome: Post hoc analysis of patients receiving cannabidiol in two randomized controlled trials.
Epilepsia.
2023 07; 64(7):1812-1820. doi:
10.1111/epi.17618. [PMID: 37052803] - Marine Deville, Corinne Charlier. Cannabidiol in urine is not a proof of CBD consumption-lesson learned from urine sample analysis in routine caseworks.
Forensic toxicology.
2023 Jul; 41(2):213-220. doi:
10.1007/s11419-022-00652-8. [PMID: 36481827] - María Eugenia Vozza Berardo, Julieta Renée Mendieta, María Daniela Villamonte, Silvana Lorena Colman, Débora Nercessian. Antifungal and antibacterial activities of Cannabis sativa L. resins.
Journal of ethnopharmacology.
2023 Jul; ?(?):116839. doi:
10.1016/j.jep.2023.116839. [PMID: 37400009] - Matej Maly, Frantisek Benes, Zuzana Binova, Marie Zlechovcova, Petr Kastanek, Jana Hajslova. Effective isolation of cannabidiol and cannabidiolic acid free of psychotropic phytocannabinoids from hemp extract by fast centrifugal partition chromatography.
Analytical and bioanalytical chemistry.
2023 Jun; ?(?):. doi:
10.1007/s00216-023-04782-9. [PMID: 37382652] - Mariia Zaiachuk, Santosh V Suryavanshi, Nazar Pryimak, Igor Kovalchuk, Olga Kovalchuk. The Anti-Inflammatory Effects of Cannabis sativa Extracts on LPS-Induced Cytokines Release in Human Macrophages.
Molecules (Basel, Switzerland).
2023 Jun; 28(13):. doi:
10.3390/molecules28134991. [PMID: 37446655] - Asta Judžentienė, Rasa Garjonytė, Jurga Būdienė. Phytochemical Composition and Antioxidant Activity of Various Extracts of Fibre Hemp (Cannabis sativa L.) Cultivated in Lithuania.
Molecules (Basel, Switzerland).
2023 Jun; 28(13):. doi:
10.3390/molecules28134928. [PMID: 37446590] - Nazeer Hasan, Mohammad Imran, Afsana Sheikh, Nidhi Tiwari, Abhinav Jaimini, Prashant Kesharwani, Gaurav Kumar Jain, Farhan Jalees Ahmad. Advanced multifunctional nano-lipid carrier loaded gel for targeted delivery of 5-flurouracil and cannabidiol against non-melanoma skin cancer.
Environmental research.
2023 Jun; 233(?):116454. doi:
10.1016/j.envres.2023.116454. [PMID: 37343751] - Sumit Bansal, C Austin Zamarripa, Tory R Spindle, Elise M Weerts, Kenneth E Thummel, Ryan Vandrey, Mary F Paine, Jashvant D Unadkat. Evaluation of Cytochrome P450-Mediated Cannabinoid-Drug Interactions in Healthy Adult Participants.
Clinical pharmacology and therapeutics.
2023 Jun; ?(?):. doi:
10.1002/cpt.2973. [PMID: 37313955] - Fangjie Jin, Yuting Wen, Guoqiang Lin, Shaopeng Yu, Chao Wang, Wenbo Ye, Jiange Zhang. Design, synthesis, and analgesia evaluation of novel Transient Receptor Potential Vanilloid 1 (TRPV1) agonists modified from Cannabidiol (CBD).
Bioorganic & medicinal chemistry.
2023 Jun; 90(?):117379. doi:
10.1016/j.bmc.2023.117379. [PMID: 37336082] - Soura Challal, Adrianna Skiba, Mélanie Langlois, Camila V Esguerra, Jean-Luc Wolfender, Alexander D Crawford, Krystyna Skalicka-Woźniak. Natural product-derived therapies for treating drug-resistant epilepsies: From ethnopharmacology to evidence-based medicine.
Journal of ethnopharmacology.
2023 Jun; ?(?):116740. doi:
10.1016/j.jep.2023.116740. [PMID: 37315641] - Nathan D Winters, Farhana Yasmin, Veronika Kondev, Brad A Grueter, Sachin Patel. Cannabidiol Differentially Modulates Synaptic Release and Cellular Excitability in Amygdala Subnuclei.
ACS chemical neuroscience.
2023 06; 14(11):2008-2015. doi:
10.1021/acschemneuro.2c00775. [PMID: 37163725] - Joanna Bartkowiak-Wieczorek, Edyta Mądry, Michał Książkiewicz, Jakub Winkler-Galicki, Milena Szalata, Marlena Szalata, Ulises Elizalde Jiménez, Karolina Wielgus, Edmund Grześkowiak, Ryszard Słomski, Agnieszka Bienert. THC-Reduced Cannabis sativa L.-How Does the Solvent Determine the Bioavailability of Cannabinoids Given Orally?.
Nutrients.
2023 Jun; 15(12):. doi:
10.3390/nu15122646. [PMID: 37375550]