Ligustilide (BioDeep_00000018945)

Main id: BioDeep_00000407596

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(3E)-3-butylidene-1,3,4,5-tetrahydro-2-benzofuran-1-one

化学式: C12H14O2 (190.0994)
中文名称: 蒿本内酯, 藁本内酯, （E） -lig本内酯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC/C=C1/OC(=O)C2=C1CCC=C2
InChI: InChI=1S/C12H14O2/c1-2-3-8-11-9-6-4-5-7-10(9)12(13)14-11/h5,7-8H,2-4,6H2,1H3/b11-8+

描述信息

Constituent of Angelica subspecies Ligustilide is found in wild celery, lovage, and herbs and spices.
Ligustilide is found in herbs and spices. Ligustilide is a constituent of Angelica specie

同义名列表

12 个代谢物同义名

(3E)-3-butylidene-1,3,4,5-tetrahydro-2-benzofuran-1-one; 3-Butylidene-4,5-dihydro-1(3H)-isobenzofuranone, 9ci; (E)-3-Butylidene-4,5-dihydroisobenzofuran-1(3H)-one; 3-Butylidene-4,5-dihydrophthalide, 8ci; ligustilide, (E)-isomer; ligustilide, (Z)-isomer; (E)-Ligustilide; Z-ligustilide; Ligustilide; KBio2_002182; Ligustilide; (E)-Ligustilide



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

66 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 BCL2, BECN1, CASP3, CAT, MAPK14, MAPK8, MTOR, NOS2, PIK3CA, PRKAA2, PTGS2, RELA, STAT3, TLR4, VEGFA
Golgi apparatus, trans-Golgi network membrane 1 BECN1
Peripheral membrane protein 3 BECN1, MTOR, PTGS2
Endosome membrane 2 BECN1, TLR4
Endoplasmic reticulum membrane 5 BCL2, BECN1, HMOX1, MTOR, PTGS2
Mitochondrion membrane 1 BECN1
Cytoplasmic vesicle, autophagosome 1 BECN1
Nucleus 14 BCL2, BECN1, CASP3, GABPA, HMOX1, JUN, MAPK14, MAPK8, MTOR, NOS2, PRKAA2, RELA, STAT3, VEGFA
autophagosome 1 BECN1
cytosol 13 BCL2, BECN1, CASP3, CAT, HMOX1, MAPK14, MAPK8, MTOR, NOS2, PIK3CA, PRKAA2, RELA, STAT3
dendrite 3 BECN1, MTOR, PRKAA2
mitochondrial membrane 1 BECN1
nuclear body 1 BECN1
phagocytic vesicle 2 BECN1, MTOR
phosphatidylinositol 3-kinase complex, class III 1 BECN1
trans-Golgi network 1 BECN1
nucleoplasm 11 CASP3, GABPA, HMOX1, JUN, MAPK14, MAPK8, MTOR, NOS2, PRKAA2, RELA, STAT3
RNA polymerase II transcription regulator complex 2 JUN, STAT3
Cell membrane 2 TLR4, TNF
Cytoplasmic side 2 HMOX1, MTOR
lamellipodium 1 PIK3CA
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell surface 3 TLR4, TNF, VEGFA
glutamatergic synapse 3 CASP3, MAPK14, RELA
Golgi apparatus 2 PRKAA2, VEGFA
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 3 CASP3, PRKAA2, TNF
Cytoplasm, cytosol 1 NOS2
Lysosome 1 MTOR
endosome 1 BECN1
plasma membrane 5 NOS2, PIK3CA, STAT3, TLR4, TNF
Membrane 7 BCL2, CAT, HMOX1, MTOR, PRKAA2, TLR4, VEGFA
axon 2 MAPK8, PRKAA2
caveola 1 PTGS2
extracellular exosome 1 CAT
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 BCL2, BECN1, HMOX1, PTGS2, VEGFA
extracellular space 4 HMOX1, IL6, TNF, VEGFA
perinuclear region of cytoplasm 4 HMOX1, NOS2, PIK3CA, TLR4
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 3 BCL2, CAT, MAPK14
protein-containing complex 3 BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 2 IL6, VEGFA
extracellular region 5 CAT, IL6, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
mitochondrial matrix 1 CAT
transcription regulator complex 3 JUN, RELA, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NOS2
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
extracellular matrix 1 VEGFA
Peroxisome 2 CAT, NOS2
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
secretory granule 1 VEGFA
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
chromatin 4 GABPA, JUN, RELA, STAT3
phagocytic cup 2 TLR4, TNF
spindle pole 1 MAPK14
nuclear chromosome 1 JUN
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
phagophore assembly site 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type I 1 BECN1
phosphatidylinositol 3-kinase complex, class III, type II 1 BECN1
cytoplasmic stress granule 1 PRKAA2
euchromatin 1 JUN
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 2 CAT, MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
Single-pass type IV membrane protein 1 HMOX1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
nucleotide-activated protein kinase complex 1 PRKAA2
Cytoplasmic vesicle, phagosome 1 MTOR
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
cytoplasmic side of mitochondrial outer membrane 1 BECN1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Beclin-1-C 35 kDa]: Mitochondrion 1 BECN1
[Beclin-1-C 37 kDa]: Mitochondrion 1 BECN1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Kaixue Zhang, Wenjuan Liu, Fukui Shen, Guoqing Luan, Yanqi Han, Jun Xu, Cheng Fu, Weidong Wu, Yuanyuan Hou, Min Jiang, Tiejun Zhang, Gang Bai. Ligustilide covalently binds to Cys703 in the pre-S1 helix of TRPA1, blocking the opening of channel and relieving pain in rats with acute soft tissue injury. Journal of ethnopharmacology. 2024 Aug; 330(?):118217. doi: 10.1016/j.jep.2024.118217. [PMID: 38641072]
  • Lianyu Zhou, Peiyan Jiang, Linyang Zhao, Xinghang Fei, Yexi Tang, Yi Luo, Hong Gong, Xiaqing Wang, Xin Li, Song Li, Chunqing Zhang, Hui Yang, Xiaotang Fan. Ligustilide inhibits Purkinje cell ferritinophagy via the ULK1/NCOA4 pathway to attenuate valproic acid-induced autistic features. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Apr; 126(?):155443. doi: 10.1016/j.phymed.2024.155443. [PMID: 38394737]
  • Zhigang Chen, Qiang Zhu, Xingyu Qi, Li-Rong Yang, Yu-Xia Rong, Qi Wei, Shi-Qi Wu, Qian-Wei Lu, Li Li, Ming-Dong Jiang, Hongyi Qi. Dual role of Nrf2/HO-1 pathway in Z-ligustilide-induced ferroptosis against AML cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155288. doi: 10.1016/j.phymed.2023.155288. [PMID: 38183698]
  • Hong-Xu Yang, Xue-Li Jiang, Rong-Mei Zuo, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Targeting RXFP1 by Ligustilide: A novel therapeutic approach for alcoholic hepatic steatosis. International immunopharmacology. 2024 Jan; 127(?):111460. doi: 10.1016/j.intimp.2023.111460. [PMID: 38157696]
  • Xie Xu, Nana Tao, Caihua Sun, Robert D Hoffman, Dongling Shi, Yuyuan Ying, Shujie Dong, Jianli Gao. Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155216. doi: 10.1016/j.phymed.2023.155216. [PMID: 38061285]
  • Pengyu Geng, Jinhui Zhao, Qi Li, Xiaolin Wang, Wangshu Qin, Ting Wang, Xianzhe Shi, Xinyu Liu, Jia Chen, Hongdeng Qiu, Guowang Xu. Z-Ligustilide Combined with Cisplatin Reduces PLPP1-Mediated Phospholipid Synthesis to Impair Cisplatin Resistance in Lung Cancer. International journal of molecular sciences. 2023 Dec; 24(23):. doi: 10.3390/ijms242317046. [PMID: 38069368]
  • Kaixue Zhang, Fukui Shen, Wei Lei, Yanqi Han, Xiaoyao Ma, Yujie Lu, Yuanyuan Hou, Wenjuan Liu, Min Jiang, Tiejun Zhang, Gang Bai. Ligustilide covalently binds to Cys129 of HMGCS1 to ameliorate dyslipidemia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Aug; 166(?):115323. doi: 10.1016/j.biopha.2023.115323. [PMID: 37579692]
  • Juan Gao, Gang Su, Wei Chen, Qionghui Wu, Junxi Liu, Jifei Liu, Miao Chai, Ying Dong, He Wang, Lixia Chen, Zhenchang Zhang, Manxia Wang. Mechanism of ligusticum cycloprolactam against neuroinflammation based on network pharmacology and experimental verification. Clinical and experimental pharmacology & physiology. 2023 Jun; ?(?):. doi: 10.1111/1440-1681.13784. [PMID: 37308175]
  • Lei Shi, Chen-Chen Jiang, Jia-Jun Lu, Zi-Xu Li, Wang-Jie Li, Xiu-Yun Yin, Zhuo Chen, Xin-Ya Zhao, Hui Zhang, Hao-Ran Hu, Lu-Tan Zhou, Jun Han. [Molecular mechanism of ligustilide attenuating OGD/R injury in PC12 cells by inhibiting ferroptosis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jun; 48(11):3046-3054. doi: 10.19540/j.cnki.cjcmm.20221201.401. [PMID: 37381963]
  • Nuerbiye Aobulikasimu, Hang Lv, Peipei Guan, Lu Cao, Xueshi Huang, Li Han. Levistolide A ameliorates fibrosis in chronic kidney disease via modulating multitarget actions in vitro and in vivo. Life sciences. 2023 May; 320(?):121565. doi: 10.1016/j.lfs.2023.121565. [PMID: 36921687]
  • Xuejiao Song, Chang Liu, Yang Zhang, Xiaoyue Xiao, Guorui Han, Kedi Sun, Shuoqi Liu, Zhiyun Zhang, Chunliu Dong, Yadan Zheng, Xueying Chen, Tong Xu, Yanyan Liu, Yanhua Li. Sustainable extraction of ligustilide and ferulic acid from Angelicae Sinensis Radix, for antioxidant and anti-inflammatory activities. Ultrasonics sonochemistry. 2023 Feb; 94(?):106344. doi: 10.1016/j.ultsonch.2023.106344. [PMID: 36871526]
  • Xueqin Chen, Jingyue Yu, Huan Lei, Lei Li, Xupin Liu, Bo Liu, Yanfei Xie, Haihong Fang. Exploring the Mechanism of Buyang Huanwu Decoction Alleviating Restenosis by Regulating VSMC Phenotype Switching and Proliferation by Network Pharmacology and Molecular Docking. Current computer-aided drug design. 2023 Feb; ?(?):. doi: 10.2174/1573409919666230203144207. [PMID: 36740793]
  • Yu-Jie Lu, Lin Niu, Fu-Kui Shen, Wen Yang, Yang Xie, Su-Yun Li, Min Jiang, Gang Bai. Ligustilide attenuates airway remodeling in COPD mice by covalently binding to MH2 domain of Smad3 in pulmonary epithelium, disrupting the Smad3-SARA interaction. Phytotherapy research : PTR. 2023 Feb; 37(2):717-730. doi: 10.1002/ptr.7655. [PMID: 36216328]
  • Kesara Na-Bangchang, Monthaka Teerachaisakul, Phunuch Muhamad, Yositha Kasemnitichok, Nattida Sangnarong, Kanyarat Boonprasert, Mayuri Tarasuk, Tullayakorn Plengsuriyakarn. Antiproliferative and Anti-Inflammatory Activities of Deprungsith Formulation and Its Bioactive Compounds Against Mild Psoriasis and Potential of Metabolic Herb-Drug Interactions. Journal of evidence-based integrative medicine. 2023 Jan; 28(?):2515690X231191101. doi: 10.1177/2515690x231191101. [PMID: 37553989]
  • Chang-Woo Ha, Eun-Hwa Sohn, Sung-Hyeok Kim, Sohee Jang, Myung-Rye Park, Youn-Kyu Kim, In-Young Bae. Fermented Angelicae tenussimae with Aspergillus oryzae Improves Skin Barrier Properties, Moisturizing, and Anti-Inflammatory Responses. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012072. [PMID: 36292928]
  • Zhiguo Mao, Liyu Tian, Jiao Liu, Qian Wu, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto. Ligustilide ameliorates hippocampal neuronal injury after cerebral ischemia reperfusion through activating PINK1/Parkin-dependent mitophagy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 101(?):154111. doi: 10.1016/j.phymed.2022.154111. [PMID: 35512628]
  • Zicen Fang, Zhenhui Luo, Yanying Ji, Rihong Yang, Jintian Gao, Nana Zhang. A network pharmacology technique used to investigate the potential mechanism of Ligustilide's effect on atherosclerosis. Journal of food biochemistry. 2022 07; 46(7):e14146. doi: 10.1111/jfbc.14146. [PMID: 35365921]
  • Dong Peng, Han-Zi Qiao, Hong-Yu Tan, Yi-Xue Wang, Dan Luo, Li-Jun Qiao, Ye-Feng Cai, Shi-Jie Zhang, Qi Wang, Li Guan. Ligustilide ameliorates cognitive impairment via AMPK/SIRT1 pathway in vascular dementia rat. Metabolic brain disease. 2022 06; 37(5):1401-1414. doi: 10.1007/s11011-022-00947-0. [PMID: 35420377]
  • Yujie Lu, Jie Ji, Simeng Chu, Fukui Shen, Wen Yang, Wei Lei, Min Jiang, Gang Bai. CaMKII, that binds with ligustilide, as a potential drug target of Suxiao jiuxin pill, a traditional Chinese medicine to dilate thoracic aorta. Clinical and translational medicine. 2022 06; 12(6):e907. doi: 10.1002/ctm2.907. [PMID: 35678102]
  • Qian Wu, Jiao Liu, Li-Yu Tian, Ning Wang. [Mitophagy mediated by ligustilide relieves OGD/R-induced injury in HT22 cells]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Apr; 47(7):1897-1903. doi: 10.19540/j.cnki.cjcmm.20211029.404. [PMID: 35534260]
  • Han Dong, Meiling Li, Ling Jin, Xiaorong Xie, Mengfei Li, Jianhe Wei. Cool Temperature Enhances Growth, Ferulic Acid and Flavonoid Biosynthesis While Inhibiting Polysaccharide Biosynthesis in Angelica sinensis. Molecules (Basel, Switzerland). 2022 Jan; 27(1):. doi: 10.3390/molecules27010320. [PMID: 35011549]
  • Qian Wu, Jiao Liu, Zhiguo Mao, Liyu Tian, Ning Wang, Guangyun Wang, Yang Wang, Saiwang Seto. Ligustilide attenuates ischemic stroke injury by promoting Drp1-mediated mitochondrial fission via activation of AMPK. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153884. doi: 10.1016/j.phymed.2021.153884. [PMID: 34929562]
  • Bin Zhang, Donghai Wu, Limei Hu, Xiaofeng Cha, Yilai Liu, Jujie Li, Bo Xie, Bin Li, Lei Zheng. Ligustilide inhibits the proliferation of human osteoblastoma MG63 cells through the TLR4-ERK pathway. Life sciences. 2022 Jan; 288(?):118993. doi: 10.1016/j.lfs.2020.118993. [PMID: 33545202]
  • Zhenhui Luo, Ao Zeng, Yuankun Chen, Shumiao He, Siqing He, Xiaobao Jin, Chunmei Li, Wenjie Mei, Qun Lu. Ligustilide inhibited Angiotensin II induced A7r5 cell autophagy via Akt/mTOR signaling pathway. European journal of pharmacology. 2021 Aug; 905(?):174184. doi: 10.1016/j.ejphar.2021.174184. [PMID: 34004211]
  • Li-Juan Gao, Ping Li, Tengyun Ma, Zhan-Qiong Zhong, Shi-Jun Xu. Ligustilide alleviates neurotoxicity in SH-SY5Y cells induced by Aβ25-35 via regulating endoplasmic reticulum stress and autophagy. Phytotherapy research : PTR. 2021 Mar; 35(3):1572-1584. doi: 10.1002/ptr.6925. [PMID: 33111362]
  • Sujuan Guo, Guofeng Wang, Zhengxiong Yang. Ligustilide alleviates the insulin resistance, lipid accumulation, and pathological injury with elevated phosphorylated AMPK level in rats with diabetes mellitus. Journal of receptor and signal transduction research. 2021 Feb; 41(1):85-92. doi: 10.1080/10799893.2020.1789877. [PMID: 32643505]
  • Xiufeng Jiang, Wei Zhao, Feng Zhu, Hui Wu, Xiao Ding, Jinmei Bai, Xiaoqing Zhang, Meifang Qian. Ligustilide inhibits the proliferation of non-small cell lung cancer via glycolytic metabolism. Toxicology and applied pharmacology. 2021 01; 410(?):115336. doi: 10.1016/j.taap.2020.115336. [PMID: 33212065]
  • Yu-Miao Gan, Dong-Ling Liu, Chu Chen, Wei Duan, Yu-Xin Yang, Jun-Rong Du. Phthalide derivative CD21 alleviates cerebral ischemia-induced neuroinflammation: Involvement of microglial M2 polarization via AMPK activation. European journal of pharmacology. 2020 Nov; 886(?):173552. doi: 10.1016/j.ejphar.2020.173552. [PMID: 32926919]
  • Xiaoxiao Wang, Yixin Yao, Chang An, Xi Li, Fangtao Xiang, Yangli Dong, Maosen Li. Simultaneous determination of 20 bioactive components in Chuanxiong Rhizoma from different production origins in Sichuan province by ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry combined with multivariate statistical analysis. Electrophoresis. 2020 10; 41(18-19):1606-1616. doi: 10.1002/elps.202000082. [PMID: 32557720]
  • Qingxuan Xie, Linlin Zhang, Long Xie, Yu Zheng, Kai Liu, Hailong Tang, Yanmei Liao, Xiaofang Li. Z-ligustilide: A review of its pharmacokinetics and pharmacology. Phytotherapy research : PTR. 2020 Aug; 34(8):1966-1991. doi: 10.1002/ptr.6662. [PMID: 32135035]
  • Yanxia Zhang, Yaming Zhang, Yanming Han, Ye Tian, Pengcheng Wu, Aiyi Xin, Xiaoning Wei, Yanbin Shi, Zhenchang Zhang, Gang Su, Yanping Shi, Junxi Liu. Pharmacokinetics, tissue distribution, and safety evaluation of a ligustilide derivative (LIGc). Journal of pharmaceutical and biomedical analysis. 2020 Apr; 182(?):113140. doi: 10.1016/j.jpba.2020.113140. [PMID: 32036300]
  • Xiaoqiong Xu, Tiantian Zhu, Tingting Shi, Juan Chen, Ling Jin. Quality suitability regionalization analysis of Angelica sinensis in Gansu, China. PloS one. 2020; 15(12):e0243750. doi: 10.1371/journal.pone.0243750. [PMID: 33315941]
  • Qinhui Wang, Tao Yan, Wei Jiang, Na Hu, Song Zhang, Peng Yang, Wenjuan Zhang, Lei Shi, Linna Liu. Simultaneous quantification of ligustilide, dl-3-n-butylphthalide and senkyunolide A in rat plasma by GC-MS and its application to comparative pharmacokinetic studies of Rhizoma Chuanxiong extract alone and Baizhi Chuanxiong Decoction. Biomedical chromatography : BMC. 2019 Oct; 33(10):e4625. doi: 10.1002/bmc.4625. [PMID: 31222844]
  • Kemal Duric, Yang Liu, Shao-Nong Chen, David C Lankin, Dejan Nikolic, James B McAlpine, J Brent Friesen, Guido F Pauli. Studying Mass Balance and the Stability of (Z)-Ligustilide from Angelica sinensis Helps to Bridge a Botanical Instability-Bioactivity Chasm. Journal of natural products. 2019 09; 82(9):2400-2408. doi: 10.1021/acs.jnatprod.8b00962. [PMID: 31478376]
  • Wei Lei, Yan-Fang Deng, Xue-Yan Hu, Jia-Nan Ni, Min Jiang, Gang Bai. Phthalides, senkyunolide A and ligustilide, show immunomodulatory effect in improving atherosclerosis, through inhibiting AP-1 and NF-κB expression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Sep; 117(?):109074. doi: 10.1016/j.biopha.2019.109074. [PMID: 31177061]
  • Wonseok Lee, Hye Ryoung Koo, You-Jin Choi, Jin Gyu Choi, Myung Sook Oh, Xing Jin, Munki Choo, Sunghyouk Park, Yoo-Seong Jeong, Suk-Jae Chung, Byung-Hoon Lee. Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo. Planta medica. 2019 Jul; 85(9-10):719-728. doi: 10.1055/a-0901-1307. [PMID: 31137047]
  • Alice M S Rodrigues, Véronique Eparvier, Guillaume Odonne, Nadine Amusant, Didier Stien, Emeline Houël. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Scientific reports. 2019 06; 9(1):8729. doi: 10.1038/s41598-019-45222-y. [PMID: 31217530]
  • Wei-Hua Yan, Hong-Hong Cao, Shuang Guo, Li-Ya Gu, Wei Hu, Ming Cheng, De-Tao Bai, Jie Chen, Chun-Qin Mao, Lin Li, Tu-Lin Lu. [UPLC fingerprint and multi-components content determination of different processed products of Angelica sinensis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019 Jun; 44(12):2499-2510. doi: 10.19540/j.cnki.cjcmm.20190321.311. [PMID: 31359717]
  • F Yang, Z W Lin, T Y Huang, T T Chen, J Cui, M Y Li, Y Q Hua. Ligustilide, a major bioactive component of Angelica sinensis, promotes bone formation via the GPR30/EGFR pathway. Scientific reports. 2019 05; 9(1):6991. doi: 10.1038/s41598-019-43518-7. [PMID: 31061445]
  • Sipeng Wu, Ning Wang, Jing Li, Guangyun Wang, Sai Wang Seto, Dennis Chang, Huazheng Liang. Ligustilide Ameliorates the Permeability of the Blood-Brain Barrier Model In Vitro During Oxygen-Glucose Deprivation Injury Through HIF/VEGF Pathway. Journal of cardiovascular pharmacology. 2019 05; 73(5):316-325. doi: 10.1097/fjc.0000000000000664. [PMID: 30855407]
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