Retinal (BioDeep_00000001872)

 

Secondary id: BioDeep_00000866948, BioDeep_00000875153

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite natural product


代谢物信息卡片


(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenal

化学式: C20H28O (284.214)
中文名称: 13-顺式视黄醇, 全反式视黄醛, 视黄醛
谱图信息: 最多检出来源 Homo sapiens(blood) 29.85%

分子结构信息

SMILES: C/C(=C\C=C\C(=C\C=O)\C)/C=C/C1=C(C)CCCC1(C)C
InChI: InChI=1S/C20H28O/c1-16(8-6-9-17(2)13-15-21)11-12-19-18(3)10-7-14-20(19,4)5/h6,8-9,11-13,15H,7,10,14H2,1-5H3/b9-6+,12-11+,16-8+,17-13+

描述信息

A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration. [HMDB]. Retinal is found in many foods, some of which are flaxseed, pepper (c. baccatum), climbing bean, and other soy product.
Retinal is a carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration.
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids
CONFIDENCE standard compound; INTERNAL_ID 142

同义名列表

27 个代谢物同义名

(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenal; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenal; 3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenal; all-trans-Vitamin a aldehyde; trans-Vitamin a aldehyde; all-trans-Retinaldehyde; Vitamin a1 aldehyde; all-epsilon-Retinal; Aldehyde, vitamin a; Vitamin a aldehyde; all-trans-Retinene; all trans-Retinal; All-trans-retinal; Retinal, 13-cis-; epsilon-Retinal; 11-cis-retinal; alpha-Retinene; 11 cis Retinal; Retinaldehyde; all-e-Retinal; trans-Retinal; Axerophthal; Retinene 1; e-Retinal; Retinene; Retinal; Retinal



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(12)

BioCyc(0)

PlantCyc(0)

代谢反应

272 个相关的代谢反应过程信息。

Reactome(253)

BioCyc(5)

WikiPathways(4)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(9)

PharmGKB(0)

58 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AKR1B1, ANG, AXIN2, CEP290, CHAT, PRPH, TBX20, TH
Nucleus 9 ANG, AXIN2, CALB2, CEP290, CHAT, FOS, KDR, TBX20, TH
cytosol 8 AKR1B1, ANG, AXIN2, CALB2, CEP290, CHAT, FOS, TH
dendrite 3 CALB2, OPN4, TH
centrosome 2 AXIN2, CEP290
nucleoplasm 2 AKR1B1, FOS
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 4 GPRC5A, GRID1, KDR, OPN4
Cell projection, axon 3 OPN4, PRPH, TH
Multi-pass membrane protein 5 ATP4A, GPRC5A, GRID1, OPN4, PRPH
Synapse 2 CALB2, CHAT
cell junction 1 KDR
cell surface 1 EPO
glutamatergic synapse 1 GRID1
Golgi apparatus 1 KDR
Golgi membrane 1 INS
growth cone 1 ANG
neuronal cell body 1 ANG
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
endosome 1 KDR
plasma membrane 7 ATP4A, AXIN2, GPRC5A, GRID1, KDR, OPN4, PRPH
terminal bouton 2 CALB2, TH
Membrane 4 ATP4A, CEP290, OPN4, PRPH
apical plasma membrane 1 ATP4A
axon 3 OPN4, PRPH, TH
extracellular exosome 5 AKR1B1, EPO, GPRC5A, GRID1, PRPH
endoplasmic reticulum 2 FOS, KDR
extracellular space 8 AKR1B1, ANG, ATP4A, CCL2, CXCL8, EPO, INS, RBP3
perinuclear region of cytoplasm 1 TH
gap junction 1 CALB2
mitochondrion 2 AKR1B1, TH
protein-containing complex 1 CEP290
intracellular membrane-bounded organelle 1 GPRC5A
Secreted 5 ANG, CCL2, CXCL8, EPO, INS
extracellular region 8 ANG, CCL2, CEP290, CXCL8, EPO, INS, KDR, RBP3
cytoplasmic side of plasma membrane 1 TH
[Isoform 2]: Secreted 1 KDR
anchoring junction 1 KDR
Cell projection, cilium 1 CEP290
centriolar satellite 1 CEP290
photoreceptor connecting cilium 1 CEP290
photoreceptor inner segment 1 PRPH
photoreceptor outer segment 1 PRPH
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CEP290
external side of plasma membrane 1 KDR
Extracellular vesicle 1 RBP3
actin cytoskeleton 1 ANG
perikaryon 3 OPN4, PRPH, TH
beta-catenin destruction complex 1 AXIN2
cytoplasmic vesicle 2 CEP290, TH
nucleolus 2 ANG, GPRC5A
Melanosome membrane 1 TH
Early endosome 1 KDR
vesicle 1 GPRC5A
postsynaptic membrane 1 GRID1
Apical cell membrane 1 ATP4A
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 KDR
Cytoplasm, cytoskeleton 1 PRPH
GABA-ergic synapse 1 GRID1
basement membrane 1 ANG
intermediate filament 1 PRPH
Postsynaptic cell membrane 1 GRID1
receptor complex 2 GPRC5A, KDR
neuron projection 2 CHAT, TH
ciliary basal body 1 CEP290
chromatin 2 FOS, TBX20
cell projection 1 CEP290
Chromosome 1 ANG
cytoskeleton 1 CEP290
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CEP290
Cytoplasm, cytoskeleton, cilium basal body 1 CEP290
centriole 1 CEP290
ciliary transition zone 1 CEP290
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite 1 CEP290
Cell projection, cilium, photoreceptor outer segment 1 PRPH
Nucleus, nucleolus 1 ANG
endosome lumen 1 INS
sorting endosome 1 KDR
Cytoplasmic vesicle membrane 1 GPRC5A
Cell projection, dendrite 1 OPN4
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
cell body 1 EPO
secretory granule lumen 2 EPO, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 FOS
specific granule lumen 1 CEP290
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
parallel fiber to Purkinje cell synapse 1 CALB2
MKS complex 1 CEP290
protein-DNA complex 1 FOS
sperm head plasma membrane 1 OPN4
type III intermediate filament 1 PRPH
photoreceptor disc membrane 1 OPN4
transcription factor AP-1 complex 1 FOS
angiogenin-PRI complex 1 ANG
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
cone matrix sheath 1 RBP3
potassium:proton exchanging ATPase complex 1 ATP4A


文献列表

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