methapyrilene (BioDeep_00001871324)
代谢物信息卡片
methapyrilene
化学式: C14H19N3S (261.13)
中文名称: 美沙吡林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)CCN(CC1=CC=CS1)C2=CC=CC=N2
InChI: InChI=1S/C14H19N3S/c1-16(2)9-10-17(12-13-6-5-11-18-13)14-7-3-4-8-15-14/h3-8,11H,9-10,12H2,1-2H3
描述信息
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AC - Substituted ethylene diamines
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
同义名列表
3 个代谢物同义名
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:6820
- PubChem: 4098
- DrugBank: DB04819
- ChEMBL: CHEMBL1411979
- MeSH: Methapyrilene
- CAS: 91-80-5
- RefMet: Methapyrilene
- KEGG: C11114
- PubChem: 13296
- KNApSAcK: 6820
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ian D Wilson, Corey Broeckling, Lee A Gethings, Nyasha C Munjoma, Robert Trengove, Paul D Rainville, Steven K Lai, Giorgis Isaac, Robert S Plumb. Development of a single mobile phase for LC-IM-MS-based discovery lipidomics and metabolic phenotyping: Application to methapyrilene hepatotoxicity in the rat.
Journal of chromatography. A.
2024 Jan; 1714(?):464552. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Hongyan Ma, Huiyun Liang, Shengxin Cai, Barry R O'Keefe, Susan L Mooberry, Robert H Cichewicz. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures.
Journal of natural products.
2021 03; 84(3):750-761. doi:
10.1021/acs.jnatprod.0c00946. [PMID: 33226219] - Markus Slopianka, Anne Herrmann, Mira Pavkovic, Heidrun Ellinger-Ziegelbauer, Rainer Ernst, Angela Mally, Matthias Keck, Bjoern Riefke. Quantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats.
Toxicology.
2017 07; 386(?):1-10. doi:
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Toxicology.
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Toxicological sciences : an official journal of the Society of Toxicology.
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Toxicology and applied pharmacology.
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PloS one.
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2011 Apr; 54(5):1128-35. doi:
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Archives of toxicology.
2008 Dec; 82(12):923-31. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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BMC biology.
2008 Jun; 6(?):25. doi:
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The Journal of toxicological sciences.
2007 Oct; 32(4):387-99. doi:
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Environmental health perspectives.
2007 Apr; 115(4):572-8. doi:
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Journal of proteome research.
2006 Jul; 5(7):1586-601. doi:
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Journal of analytical toxicology.
2006 May; 30(4):287-92. doi:
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Mutation research.
2004 May; 549(1-2):147-67. doi:
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Toxicology.
2002 Dec; 180(3):233-48. doi:
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Toxicologic pathology.
2002 Jul; 30(4):470-82. doi:
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Laboratory animals.
2002 Jul; 36(3):313-21. doi:
10.1258/002367702320162414. [PMID: 12144742] - G S Ratra, C J Powell, B K Park, J L Maggs, S Cottrell. Methapyrilene hepatotoxicity is associated with increased hepatic glutathione, the formation of glucuronide conjugates, and enterohepatic recirculation.
Chemico-biological interactions.
2000 Dec; 129(3):279-95. doi:
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Mutation research.
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Xenobiotica; the fate of foreign compounds in biological systems.
1988 Jul; 18(7):869-81. doi:
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Carcinogenesis.
1988 Jun; 9(6):959-63. doi:
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British journal of cancer.
1987 Dec; 56(6):774-8. doi:
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1986 Sep; 7(9):1405-10. doi:
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Cancer research.
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Regulatory toxicology and pharmacology : RTP.
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1985 Feb; 5(1):165-74. doi:
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Journal of chromatography.
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Clinical pharmacology and therapeutics.
1981 Apr; 29(4):527-32. doi:
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