Tetrahydro-1,4-oxazine (BioDeep_00001871316)
Main id: BioDeep_00000003049
代谢物信息卡片
Tetrahydro-1,4-oxazine
化学式: C4H9NO (87.0684)
中文名称: 吗啡啉, 吗啉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1COCCN1
InChI: InChI=1S/C4H9NO/c1-3-6-4-2-5-1/h5H,1-4H2
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:34856
- KEGG: C14452
- PubChem: 8083
- DrugBank: DB13669
- ChEMBL: CHEMBL276518
- CAS: 110-91-8
- PubChem: 17395452
- PDB-CCD: 6LR
- NIKKAJI: J2.453H
- KNApSAcK: 34856
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lin Zhang, Yuping Wei, Ye Tao, Suya Zhao, Xuyang Wei, Xiaoyan Yin, Suyao Liu, Qiuhong Niu. Molecular mechanism of the smart attack of pathogenic bacteria on nematodes.
Microbial biotechnology.
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Journal of biomolecular structure & dynamics.
2019 09; 37(14):3788-3802. doi:
10.1080/07391102.2018.1527724. [PMID: 30277419] - Seyed Ali Hosseini, Mahboube Eslami Moghadam, Maryam Saeidifar, Ali Akbar Saboury. Biological effect and molecular docking of anticancer palladium and platinum complexes with morpholine dithiocarbamate on human serum albumin as a blood carrier protein.
Canadian journal of physiology and pharmacology.
2018 Dec; 96(12):1276-1285. doi:
10.1139/cjpp-2017-0693. [PMID: 30278151] - Maria G Katselou, Alexios N Matralis, Angeliki P Kourounakis. Developing potential agents against atherosclerosis: Design, synthesis and pharmacological evaluation of novel dual inhibitors of oxidative stress and Squalene Synthase activity.
European journal of medicinal chemistry.
2017 Sep; 138(?):748-760. doi:
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Drug testing and analysis.
2016 Oct; 8(10):1039-1048. doi:
10.1002/dta.1938. [PMID: 26810883] - Eleni M Ladopoulou, Alexios N Matralis, Anastasios Nikitakis, Angeliki P Kourounakis. Antihyperlipidemic morpholine derivatives with antioxidant activity: An investigation of the aromatic substitution.
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10.1007/978-1-61779-851-1_27. [PMID: 22639272] - Hong Wang, Sanna Lehtonen, Yu-Chia Chen, Eija Heikkilä, Pertti Panula, Harry Holthöfer. Neph3 associates with regulation of glomerular and neural development in zebrafish.
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2012 Jan; 83(1):38-46. doi:
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Disease models & mechanisms.
2011 Nov; 4(6):777-85. doi:
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Molecules (Basel, Switzerland).
2011 Oct; 16(11):8945-57. doi:
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Human molecular genetics.
2011 Oct; 20(20):4041-55. doi:
10.1093/hmg/ddr332. [PMID: 21816947] - Ching-Ti Liu, Maija K Garnaas, Adrienne Tin, Anna Kottgen, Nora Franceschini, Carmen A Peralta, Ian H de Boer, Xiaoning Lu, Elizabeth Atkinson, Jingzhong Ding, Michael Nalls, Daniel Shriner, Josef Coresh, Abdullah Kutlar, Kirsten Bibbins-Domingo, David Siscovick, Ermeg Akylbekova, Sharon Wyatt, Brad Astor, Josef Mychaleckjy, Man Li, Muredach P Reilly, Raymond R Townsend, Adebowale Adeyemo, Alan B Zonderman, Mariza de Andrade, Stephen T Turner, Thomas H Mosley, Tamara B Harris, Charles N Rotimi, Yongmei Liu, Sharon L R Kardia, Michele K Evans, Michael G Shlipak, Holly Kramer, Michael F Flessner, Albert W Dreisbach, Wolfram Goessling, L Adrienne Cupples, W Linda Kao, Caroline S Fox. Genetic association for renal traits among participants of African ancestry reveals new loci for renal function.
PLoS genetics.
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Biological chemistry.
2011 Jul; 392(7):653-64. doi:
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Analytical and bioanalytical chemistry.
2011 May; 400(4):1137-44. doi:
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2011 May; 3(5):258-65. doi:
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PLoS genetics.
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Dermato-endocrinology.
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Developmental biology.
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Developmental biology.
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Development (Cambridge, England).
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PloS one.
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PloS one.
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Current medicinal chemistry.
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Methods in molecular biology (Clifton, N.J.).
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Methods in molecular biology (Clifton, N.J.).
2011; 770(?):423-38. doi:
10.1007/978-1-61779-210-6_16. [PMID: 21805274] - Bluma Linkowski Faintuch, Gustavo Eutimio Fernandez Núñez, Rodrigo Teodoro, Ana M Moro, Jair Mengatti. Radiolabeled nano-peptides show specificity for an animal model of human PC3 prostate cancer cells.
Clinics (Sao Paulo, Brazil).
2011; 66(2):327-36. doi:
10.1590/s1807-59322011000200024. [PMID: 21484054] - Jaana Hyvärinen, Mataleena Parikka, Raija Sormunen, Mika Rämet, Karl Tryggvason, Kari I Kivirikko, Johanna Myllyharju, Peppi Koivunen. Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function.
The Journal of biological chemistry.
2010 Dec; 285(53):42023-32. doi:
10.1074/jbc.m110.145904. [PMID: 20952382] - Asitha T Silva, Alien Nguyen, Changming Ye, Jeanmarie Verchot, Joong Ho Moon. Conjugated polymer nanoparticles for effective siRNA delivery to tobacco BY-2 protoplasts.
BMC plant biology.
2010 Dec; 10(?):291. doi:
10.1186/1471-2229-10-291. [PMID: 21192827] - David E Saslowsky, Jin Ah Cho, Himani Chinnapen, Ramiro H Massol, Daniel J-F Chinnapen, Jessica S Wagner, Heidi E De Luca, Wendy Kam, Barry H Paw, Wayne I Lencer. Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2.
The Journal of clinical investigation.
2010 Dec; 120(12):4399-4409. doi:
10.1172/jci42958. [PMID: 21041954] - Michael R Elizondo, Erine H Budi, David M Parichy. trpm7 regulation of in vivo cation homeostasis and kidney function involves stanniocalcin 1 and fgf23.
Endocrinology.
2010 Dec; 151(12):5700-9. doi:
10.1210/en.2010-0853. [PMID: 20881241] - Alba Diz-Muñoz, Michael Krieg, Martin Bergert, Itziar Ibarlucea-Benitez, Daniel J Muller, Ewa Paluch, Carl-Philipp Heisenberg. Control of directed cell migration in vivo by membrane-to-cortex attachment.
PLoS biology.
2010 Nov; 8(11):e1000544. doi:
10.1371/journal.pbio.1000544. [PMID: 21151339] - Qiaoli Li, Sara Sadowski, Michael Frank, Chunli Chai, Andras Váradi, Shiu-Ying Ho, Hong Lou, Michael Dean, Christine Thisse, Bernard Thisse, Jouni Uitto. The abcc6a gene expression is required for normal zebrafish development.
The Journal of investigative dermatology.
2010 Nov; 130(11):2561-8. doi:
10.1038/jid.2010.174. [PMID: 20596085] - Nobuyuki Itoh. Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease.
Cell and tissue research.
2010 Oct; 342(1):1-11. doi:
10.1007/s00441-010-1024-2. [PMID: 20730630] - Célia Ferreira, Sónia Silva, Fábio Faria-Oliveira, Eva Pinho, Mariana Henriques, Cândida Lucas. Candida albicans virulence and drug-resistance requires the O-acyltransferase Gup1p.
BMC microbiology.
2010 Sep; 10(?):238. doi:
10.1186/1471-2180-10-238. [PMID: 20843317] - Sharon Ashworth, Beina Teng, Jessica Kaufeld, Emily Miller, Irini Tossidou, Christoph Englert, Frank Bollig, Lynne Staggs, Ian S D Roberts, Joon-Keun Park, Hermann Haller, Mario Schiffer. Cofilin-1 inactivation leads to proteinuria--studies in zebrafish, mice and humans.
PloS one.
2010 Sep; 5(9):e12626. doi:
10.1371/journal.pone.0012626. [PMID: 20838616] - George Zanazzi, Gary Matthews. Enrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development.
Neural development.
2010 Sep; 5(?):24. doi:
10.1186/1749-8104-5-24. [PMID: 20809954] - Eriko Avsar-Ban, Hisayoshi Ishikawa, Hiroshi Manya, Masatoki Watanabe, Shinichi Akiyama, Hideo Miyake, Tamao Endo, Yutaka Tamaru. Protein O-mannosylation is necessary for normal embryonic development in zebrafish.
Glycobiology.
2010 Sep; 20(9):1089-102. doi:
10.1093/glycob/cwq069. [PMID: 20466645] - Murli Manohar, Hui Mei, Andrew J Franklin, Elly M Sweet, Toshiro Shigaki, Bruce B Riley, Colin W Macdiarmid, Kendal Hirschi. Zebrafish (Danio rerio) endomembrane antiporter similar to a yeast cation/H(+) transporter is required for neural crest development.
Biochemistry.
2010 Aug; 49(31):6557-66. doi:
10.1021/bi100362k. [PMID: 20578725] - Jianyin Long, Yin Wang, Wenjian Wang, Benny H J Chang, Farhad R Danesh. Identification of microRNA-93 as a novel regulator of vascular endothelial growth factor in hyperglycemic conditions.
The Journal of biological chemistry.
2010 Jul; 285(30):23457-65. doi:
10.1074/jbc.m110.136168. [PMID: 20501654] - Elke Neumann-Haefelin, Albrecht Kramer-Zucker, Krasimir Slanchev, Björn Hartleben, Foteini Noutsou, Katrin Martin, Nicola Wanner, Alexander Ritter, Markus Gödel, Philip Pagel, Xiao Fu, Alexandra Müller, Ralf Baumeister, Gerd Walz, Tobias B Huber. A model organism approach: defining the role of Neph proteins as regulators of neuron and kidney morphogenesis.
Human molecular genetics.
2010 Jun; 19(12):2347-59. doi:
10.1093/hmg/ddq108. [PMID: 20233749] - Krishna Prasadan, Sidhartha Tulachan, Ping Guo, Chiyo Shiota, Sohail Shah, George Gittes. Endocrine-committed progenitor cells retain their differentiation potential in the absence of neurogenin-3 expression.
Biochemical and biophysical research communications.
2010 Jun; 396(4):1036-41. doi:
10.1016/j.bbrc.2010.05.058. [PMID: 20471370] - László G Puskás, Liliána Z Fehér, Csaba Vizler, Ferhan Ayaydin, Erzsébet Rásó, Eszter Molnár, István Magyary, Iván Kanizsai, Márió Gyuris, Ramóna Madácsi, Gabriella Fábián, Klaudia Farkas, Péter Hegyi, Ferenc Baska, Béla Ozsvári, Klára Kitajka. Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells.
Lipids in health and disease.
2010 Jun; 9(?):56. doi:
10.1186/1476-511x-9-56. [PMID: 20525221] - Jeffrey T White, Bo Zhang, Débora M Cerqueira, Uyen Tran, Oliver Wessely. Notch signaling, wt1 and foxc2 are key regulators of the podocyte gene regulatory network in Xenopus.
Development (Cambridge, England).
2010 Jun; 137(11):1863-73. doi:
10.1242/dev.042887. [PMID: 20431116] - Neelakanteswar Aluru, John F Leatherland, Mathilakath M Vijayan. Bisphenol A in oocytes leads to growth suppression and altered stress performance in juvenile rainbow trout.
PloS one.
2010 May; 5(5):e10741. doi:
10.1371/journal.pone.0010741. [PMID: 20505776] - Darryl Y Nishimura, Lisa M Baye, Rahat Perveen, Charles C Searby, Almudena Avila-Fernandez, Ines Pereiro, Carmen Ayuso, Diana Valverde, Paul N Bishop, Forbes D C Manson, Jill Urquhart, Edwin M Stone, Diane C Slusarski, Graeme C M Black, Val C Sheffield. Discovery and functional analysis of a retinitis pigmentosa gene, C2ORF71.
American journal of human genetics.
2010 May; 86(5):686-95. doi:
10.1016/j.ajhg.2010.03.005. [PMID: 20398886] - Myoung Shin Kim, Seung Kew Yoon, Frank Bollig, Jirouta Kitagaki, Wonhee Hur, Nathan J Whye, Yun-Ping Wu, Miguel N Rivera, Jik Young Park, Ho-Shik Kim, Karim Malik, Daphne W Bell, Christoph Englert, Alan O Perantoni, Sean Bong Lee. A novel Wilms tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway.
The Journal of biological chemistry.
2010 May; 285(19):14585-93. doi:
10.1074/jbc.m109.094334. [PMID: 20220130] - Xiao-Gang Tong, Li-Li Zhou, Yue-Hu Wang, Chengfeng Xia, Ye Wang, Min Liang, Fan-Fan Hou, Yong-Xian Cheng. Acortatarins A and B, two novel antioxidative spiroalkaloids with a naturally unusual morpholine motif from Acorus tatarinowii.
Organic letters.
2010 Apr; 12(8):1844-7. doi:
10.1021/ol100451p. [PMID: 20329735] - Frédérique van Holthoon, Patrick P J Mulder, Eric O van Bennekom, Henri Heskamp, Tina Zuidema, Hans J A van Rhijn. Quantitative analysis of penicillins in porcine tissues, milk and animal feed using derivatisation with piperidine and stable isotope dilution liquid chromatography tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2010 Apr; 396(8):3027-40. doi:
10.1007/s00216-010-3523-0. [PMID: 20186537] - Emilie Combet, Tom Preston, Kenneth E L McColl. Development of an in vitro system combining aqueous and lipid phases as a tool to understand gastric nitrosation.
Rapid communications in mass spectrometry : RCM.
2010 Mar; 24(5):529-34. doi:
10.1002/rcm.4388. [PMID: 20112267] - Scott J Balsitis, Katherine L Williams, Ruben Lachica, Diana Flores, Jennifer L Kyle, Erin Mehlhop, Syd Johnson, Michael S Diamond, P Robert Beatty, Eva Harris. Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification.
PLoS pathogens.
2010 Feb; 6(2):e1000790. doi:
10.1371/journal.ppat.1000790. [PMID: 20168989] - Ulrike Naumann, Elisabetta Cameroni, Monika Pruenster, Harsha Mahabaleshwar, Erez Raz, Hans-Günter Zerwes, Antal Rot, Marcus Thelen. CXCR7 functions as a scavenger for CXCL12 and CXCL11.
PloS one.
2010 Feb; 5(2):e9175. doi:
10.1371/journal.pone.0009175. [PMID: 20161793] - Nicholas Matluk, Jennifer A Rochira, Aldona Karaczyn, Tamara Adams, Joseph M Verdi. A role for NRAGE in NF-kappaB activation through the non-canonical BMP pathway.
BMC biology.
2010 Jan; 8(?):7. doi:
10.1186/1741-7007-8-7. [PMID: 20100315] - E A Rekka, P N Kourounakis. Medicinal chemistry of 2,2,4-substituted morpholines.
Current medicinal chemistry.
2010; 17(29):3422-30. doi:
10.2174/092986710793176276. [PMID: 20712564] - Hideo Sugita, Shin'ichi Takeda. Progress in muscular dystrophy research with special emphasis on gene therapy.
Proceedings of the Japan Academy. Series B, Physical and biological sciences.
2010; 86(7):748-56. doi:
10.2183/pjab.86.748. [PMID: 20689232] - Thomas W Sturgill, Michael N Hall. Activating mutations in TOR are in similar structures as oncogenic mutations in PI3KCalpha.
ACS chemical biology.
2009 Dec; 4(12):999-1015. doi:
10.1021/cb900193e. [PMID: 19902965] - Hui Ma, Trevor Blake, Ajay Chitnis, Paul Liu, Tamas Balla. Crucial role of phosphatidylinositol 4-kinase IIIalpha in development of zebrafish pectoral fin is linked to phosphoinositide 3-kinase and FGF signaling.
Journal of cell science.
2009 Dec; 122(Pt 23):4303-10. doi:
10.1242/jcs.057646. [PMID: 19887586] - Krishnamurthy Konduru, Siham M Nakamura, Gerardo G Kaplan. Hepatitis A virus (HAV) packaging size limit.
Virology journal.
2009 Nov; 6(?):204. doi:
10.1186/1743-422x-6-204. [PMID: 19922643] - M M Löwik, P J Groenen, E N Levtchenko, L A Monnens, L P van den Heuvel. Molecular genetic analysis of podocyte genes in focal segmental glomerulosclerosis--a review.
European journal of pediatrics.
2009 Nov; 168(11):1291-304. doi:
10.1007/s00431-009-1017-x. [PMID: 19562370] - Wei Song, Deepthi Pabbisetty, Elizabeth A Groeber, Rick C Steenwyk, Douglas M Fast. Comparison of fused-core and conventional particle size columns by LC-MS/MS and UV: application to pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2009 Oct; 50(3):491-500. doi:
10.1016/j.jpba.2009.05.011. [PMID: 19540084] - Richard W Naylor, Robert J Collins, Anna Philpott, Elizabeth A Jones. Normal levels of p27 are necessary for somite segmentation and determining pronephric organ size.
Organogenesis.
2009 Oct; 5(4):201-10. doi:
10.4161/org.5.4.9973. [PMID: 20539739] - M Bayaa, B Vulesevic, A Esbaugh, M Braun, M E Ekker, M Grosell, S F Perry. The involvement of SLC26 anion transporters in chloride uptake in zebrafish (Danio rerio) larvae.
The Journal of experimental biology.
2009 Oct; 212(Pt 20):3283-95. doi:
10.1242/jeb.033910. [PMID: 19801433] - Caroline R Sussman, Jinhua Zhao, Consuelo Plata, Jing Lu, Christopher Daly, Nathan Angle, Jennifer DiPiero, Iain A Drummond, Jennifer O Liang, Walter F Boron, Michael F Romero, Min-Hwang Chang. Cloning, localization, and functional expression of the electrogenic Na+ bicarbonate cotransporter (NBCe1) from zebrafish.
American journal of physiology. Cell physiology.
2009 Oct; 297(4):C865-75. doi:
10.1152/ajpcell.00679.2008. [PMID: 19625604] - Yvonne A R White, Joshua T Kyle, Antony W Wood. Targeted gene knockdown in zebrafish reveals distinct intraembryonic functions for insulin-like growth factor II signaling.
Endocrinology.
2009 Sep; 150(9):4366-75. doi:
10.1210/en.2009-0356. [PMID: 19443571]
