PS-5 (BioDeep_00001870290)

Main id: BioDeep_00000011669

 


代谢物信息卡片


3-(2-Acetamidoethyl)thio-6-ethyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid

化学式: C13H18N2O4S (298.0987)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C2CC(=C(N2C1=O)C(=O)O)SCCNC(=O)C
InChI: InChI=1S/C13H18N2O4S/c1-3-8-9-6-10(20-5-4-14-7(2)16)11(13(18)19)15(9)12(8)17/h8-9H,3-6H2,1-2H3,(H,14,16)(H,18,19)/t8-,9-/m1/s1

描述信息

D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D013845 - Thienamycins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams

同义名列表

2 个代谢物同义名

3-(2-Acetamidoethyl)thio-6-ethyl-7-oxo-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid; PS-5



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 APOE, BCL2, CAT, ERBB2, JAK2, OPA1, PIK3CA, SOCS1, STAT1
Peripheral membrane protein 2 CTSB, JAK2
Endosome membrane 1 ERBB2
Endoplasmic reticulum membrane 4 BCL2, HMOX1, PSEN1, PSEN2
Nucleus 10 APOE, BCL2, ERBB2, GABPA, HMOX1, JAK2, PDE4B, PSEN1, SOCS1, STAT1
cytosol 10 BCL2, CAT, ERBB2, HMOX1, JAK2, OPA1, PDE4B, PIK3CA, SOCS1, STAT1
dendrite 4 APOE, OPA1, PSEN1, STAT1
mitochondrial membrane 1 OPA1
centrosome 3 PDE4B, PSEN1, PSEN2
nucleoplasm 8 ERBB2, GABPA, HMOX1, JAK2, OPA1, PSEN1, SOCS1, STAT1
RNA polymerase II transcription regulator complex 1 STAT1
Cell membrane 3 ERBB2, PDE4B, PSEN1
Cytoplasmic side 1 HMOX1
lamellipodium 1 PIK3CA
ruffle membrane 1 ERBB2
Cell projection, axon 1 PSEN1
Cell projection, growth cone 1 PSEN1
Cytoplasmic granule 1 PSEN1
Early endosome membrane 1 PSEN1
Multi-pass membrane protein 2 PSEN1, PSEN2
Golgi apparatus membrane 2 PSEN1, PSEN2
Synapse 1 PSEN1
cell cortex 1 PSEN1
cell junction 1 PSEN1
cell surface 1 PSEN1
ciliary rootlet 1 PSEN1
dendritic shaft 1 PSEN1
gamma-secretase complex 2 PSEN1, PSEN2
glutamatergic synapse 3 APOE, JAK2, PSEN1
Golgi apparatus 3 APOE, PSEN1, PSEN2
Golgi membrane 2 PSEN1, PSEN2
growth cone 1 PSEN1
lysosomal membrane 1 PSEN1
mitochondrial inner membrane 2 OPA1, PSEN1
neuromuscular junction 2 ERBB2, PSEN1
neuronal cell body 2 APOE, PSEN1
postsynapse 2 JAK2, PSEN1
presynaptic membrane 3 ERBB2, PSEN1, PSEN2
sarcolemma 1 PSEN1
smooth endoplasmic reticulum 1 PSEN1
synaptic vesicle 3 PDE4B, PSEN1, PSEN2
Lysosome 1 CTSB
plasma membrane 6 APOE, ERBB2, JAK2, PIK3CA, PSEN1, PSEN2
Membrane 9 APOE, BCL2, CAT, ERBB2, HMOX1, JAK2, OPA1, PSEN1, PSEN2
apical plasma membrane 2 CTSB, ERBB2
axon 2 PSEN1, STAT1
basolateral plasma membrane 1 ERBB2
caveola 1 JAK2
extracellular exosome 3 APOE, CAT, CTSB
endoplasmic reticulum 5 APOE, BCL2, HMOX1, PSEN1, PSEN2
extracellular space 5 APOE, CCL2, CTSB, CXCL10, HMOX1
perinuclear region of cytoplasm 6 CTSB, ERBB2, HMOX1, PDE4B, PIK3CA, STAT1
intercalated disc 1 PIK3CA
mitochondrion 4 BCL2, CAT, OPA1, PSEN1
protein-containing complex 5 BCL2, CAT, PSEN1, PSEN2, STAT1
intracellular membrane-bounded organelle 1 CAT
postsynaptic density 1 PDE4B
Single-pass type I membrane protein 1 ERBB2
Secreted 3 APOE, CCL2, CXCL10
extracellular region 6 APOE, CAT, CCL2, CTSB, CXCL10, ERBB2
cytoplasmic side of plasma membrane 1 JAK2
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 BCL2, OPA1
mitochondrial outer membrane 3 BCL2, HMOX1, OPA1
excitatory synapse 1 PDE4B
mitochondrial matrix 1 CAT
Extracellular side 1 CTSB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, PSEN1
external side of plasma membrane 2 CTSB, CXCL10
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
dendritic spine 1 PDE4B
Z disc 1 PDE4B
cytoplasmic vesicle 2 ERBB2, SOCS1
nucleolus 1 STAT1
axon cytoplasm 1 OPA1
Early endosome 4 APOE, ERBB2, PSEN1, PSEN2
Apical cell membrane 1 CTSB
Cell projection, ruffle membrane 1 ERBB2
Cytoplasm, perinuclear region 1 ERBB2
Mitochondrion inner membrane 1 OPA1
Membrane raft 2 JAK2, PSEN1
pore complex 1 BCL2
focal adhesion 2 CAT, JAK2
microtubule 1 OPA1
extracellular matrix 1 APOE
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 OPA1
mitochondrial intermembrane space 1 OPA1
collagen-containing extracellular matrix 2 APOE, CTSB
nuclear inner membrane 1 PSEN2
nuclear outer membrane 1 PSEN1
receptor complex 1 ERBB2
Cell projection, neuron projection 1 PSEN1
neuron projection 1 PSEN1
chromatin 2 GABPA, STAT1
cytoskeleton 1 JAK2
mitochondrial crista 1 OPA1
cytoplasmic ribonucleoprotein granule 1 SOCS1
Secreted, extracellular space 2 APOE, CTSB
blood microparticle 1 APOE
Endomembrane system 2 JAK2, PSEN2
endosome lumen 1 JAK2
Melanosome 2 APOE, CTSB
euchromatin 1 JAK2
myelin sheath 2 BCL2, ERBB2
basal plasma membrane 1 ERBB2
ficolin-1-rich granule lumen 2 CAT, CTSB
secretory granule lumen 1 CAT
endoplasmic reticulum lumen 1 APOE
voltage-gated calcium channel complex 1 PDE4B
phosphatidylinositol 3-kinase complex 2 PIK3CA, SOCS1
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
kinetochore 2 PSEN1, PSEN2
azurophil granule membrane 1 PSEN1
aggresome 1 PSEN1
Single-pass type IV membrane protein 1 HMOX1
semaphorin receptor complex 1 ERBB2
clathrin-coated endocytic vesicle membrane 1 APOE
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
synaptic cleft 1 APOE
[Isoform 1]: Cell membrane 1 ERBB2
Rough endoplasmic reticulum 1 PSEN1
[Dynamin-like GTPase OPA1, long form]: Mitochondrion inner membrane 1 OPA1
[Dynamin-like GTPase OPA1, short form]: Mitochondrion intermembrane space 1 OPA1
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
peptidase inhibitor complex 1 CTSB
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
catalase complex 1 CAT
ERBB3:ERBB2 complex 1 ERBB2
endolysosome lumen 1 CTSB
BAD-BCL-2 complex 1 BCL2
gamma-tubulin complex 1 PDE4B
ISGF3 complex 1 STAT1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[Isoform PDE4B5]: Cytoplasm 1 PDE4B


文献列表

  • M Sakamoto, K Yamamoto, K Isshiki, H Tone, T Ishikura, Y Fukagawa, T Yoshioka. Kinetic analysis of dehydropeptidase-I and comparative in vitro and in vivo stabilities of PS-5 derivatives modified at the C-3 side chain. Chemical & pharmaceutical bulletin. 1991 Feb; 39(2):341-8. doi: 10.1248/cpb.39.341. [PMID: 2054858]
  • N Shibamoto, M Sakamoto, Y Fukagawa, T Ishikura. Pharmacological studies on carbapenem antibiotics. II. Isolation of a PS-5-inactivating factor from the rat kidney. The Journal of antibiotics. 1982 Jun; 35(6):729-35. doi: 10.7164/antibiotics.35.729. [PMID: 6811539]
  • N Shibamoto, M Sakamoto, H Iguchi, H Tone, Y Fukagawa, T Ishikura. Pharmacological studies on carbapenem antibiotics. I. Metabolism of PS-5 in animal tissues. The Journal of antibiotics. 1982 Jun; 35(6):721-8. doi: 10.7164/antibiotics.35.721. [PMID: 6811538]
  • N Shibamoto, T Yoshioka, M Sakamoto, Y Fukagawa, T Ishikura. Pharmacological studies on carbapenem antibiotics. III. Chemical structure of PS-5D III, the primary renal metabolite of PS-5. The Journal of antibiotics. 1982 Jun; 35(6):736-41. doi: 10.7164/antibiotics.35.736. [PMID: 6981638]
  • Y Fukagawa, K Kubo, T Ishikura, K Kouno. Deacetylation of PS-5, a new beta-lactam compound, I. Microbial deacetylation of PS-5. The Journal of antibiotics. 1980 Jun; 33(6):543-9. doi: 10.7164/antibiotics.33.543. [PMID: 6897941]